A means to reduce the toxicity of chemically synthesized anti-tb drugs |
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IPC classes for russian patent A means to reduce the toxicity of chemically synthesized anti-tb drugs (RU 2190417):
A method of treatment of tuberculosis of the respiratory organs with severe exudative reaction in children / 2189234
The invention relates to medicine, to Institute, to methods of treatment of tuberculosis of the respiratory organs with severe exudative reaction in children
The method of treatment of pulmonary tuberculosis / 2188644
The invention relates to medicine
The way knee arthroplasty in patients undergoing tb drives / 2188588
The invention relates to medicine, Orthopaedics and traumatology, can be used in the prosthetic knee joint in patients undergoing TB drives
 Composition for treatment of pulmonary infections / 2185818
The invention relates to medicine and pharmacology, and relates to a composition for the treatment of pulmonary infections
 Tuberculostatic agent / 2185170
The invention relates to medicine, in particular tuberculosis and concerns chemotherapeutically antibacterial drugs for treatment of tuberculosis
 Composition for treatment of tuberculosis / 2185168
The invention relates to medicine and can be used in the treatment of tuberculosis
 For the treatment of tuberculosis with low complications fibrocycstic / 2185166
The invention relates to medicine, in particular to the treatment for tuberculosis with low fibrocycstic complications, which represents a conjugate isoniazid-dextran with molecular weight of 65-75 KD, of the formula:
 < / BR>where R1-N - glucose balance or polyglucosides the balance indicated on the drawing type; R2- the rest of isoniazid formula  < / BR>or hydroxyl group  Tablet antimicrobial action / 2185165
The invention relates to medicine, namely to the pharmaceutical industry, and can be used for the treatment of diseases that have arisen as a result of tuberculosis and chlamydia infection
 A method of reducing resistance of mycobacterium tuberculosis to rifampicin and ethambutol in the experiment / 2185162
The invention relates to medicine, in particular tuberculosis, and can be used to treat tuberculosis
 Injectable dosage form of metronidazole / 2173993
The invention relates to medicine, veterinary medicine and relates to injectable dosage form of metronidazole
 Pharmaceutical composition for treatment of a person with immunotropic effect / 2188659
The invention relates to medicine, specifically in terms of its composition, a pharmaceutical composition having immunotropic effect, which can be used for therapy of human diseases involving a dysfunction of the immune system
Method optimization antiaggregatory treatment of patients with cerebrovascular diseases / 2188008
The invention relates to medicine, namely to methods of optimization antiaggregatory treatment of patients with cerebrovascular diseases)
 The method of treatment of microbial eczema / 2185194
The invention relates to medicine, dermatology, to methods for treating microbial eczema
 Extracts of shark cartilage having protivoallergicheskim, anti-inflammatory, antiangiogenic and antitumor activity, method of production, methods of use and compositions containing them / 2181292
The invention relates to cartilage extracts and method of production thereof
 The method for obtaining solutions of sodium nukleospermata / 2180229
The invention relates to medicine, and is concerned with the obtaining of sodium nukleospermata
 The method of obtaining the application tools / 2179456
The invention relates to pharmaceutical industry
Biologically active food supplement "denkavit" / 2176893
The invention relates to food processing and medical industry, namely, biologically active food additives
The method of treatment in children disease sheuerman-mau / 2187308
The invention relates to medicine
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(57) Abstract: The invention relates to medicine and veterinary medicine. Apply sodium salt of DNA from milk fish as a means to reduce the toxicity of chemically synthesized drug isoniazid or diazona at its introduction into the body for the prevention or treatment of tuberculosis. Effect: the invention expands the range of tools that reduce the toxicity of the chemical and pharmaceutical drugs. The invention relates to medicine and veterinary medicine and can be used as a means to reduce the toxicity of pharmaceutical drugs. The search for improvement and development of biologically active substances for effective immunization, chemoprophylaxis and treatment of chronic bacterial infections of humans and animals, especially tuberculosis, is currently one of the urgent problems of medicine and veterinary medicine, and therefore the DNA preparations can be very promising if you are sharing them with new chemotherapy drugs. It is known the use of an extract of juniper berries as a means to reduce the e plants. - M., 1993. - S. 140-141). Antitoxic properties of the extract of juniper berries is due to the content of organic acids (malic, acetic and mouravyinna), and the presence of essential oil terpineol. The extract of juniper berries enhances motor activity of the gastrointestinal tract of the body, thereby promoting the excretion of toxic substances. However, the prolonged administration of the extract of juniper berries in the body has a toxic effect, causing irritation of renal parenchyma. The drug is contraindicated in acute kidney disease, is not assigned for a long time. It is known the use of succinic acid in a dose of 100-200 mg per day as a means to reduce the toxicity of high doses of drugs such as vitamin D2(RF patent 2125449, IPC a 61 K 31/19, publ. 27.01.99 year). It is also known the use of vitamins a or E as a means to reduce the toxicity of high doses of vitamin D2(Melz A. L. et. al. // J. Nutrition. - 1986. - Vol. 115.- p.929-935). However, the above analogues have a high toxic effect. It is known the use of mannitol in the form of a solution in a physiologically tolerable of liquids the political actions chemotherapy (C. Skrezek, H. Bertermann, F.-P. Schulz und B. Konig. - NAG-Ein sensitiver Marker fur Nierenfunktionsstorungen // J. Urologe [A], 1990, 29 p.27-31). However, mannitol has a low protective antitoxic action. It is known the use of a mixture of neutral L-amino acids, g/l: L-glycine 9-11; L-alanine 12-17; L-serine 10-18; L-threonine 2-5; L-valine 5-10; L-leucine 6-10; L-isoleucine 2-4; L-Proline 6-12 as a vehicle for intravenous administration to protect the kidneys from the toxic effects of the cytotoxic drugs (RF Patent 2077883, IPC a 61 K 31/195, publ. 27.04.97 year). We offer a mixture of neutral L-amino acids irreversibly blocks the activation system autophagy in renal cell, which prevents the occurrence of nephrotoxic effect when receiving cytotoxic drugs. However, the above drug-similar (a mixture of neutral L-amino acids) itself has a toxic effect, requires strict dosing is not recommended for long-term use. The closest technical solution (prototype) is the use of natural metabolic drug liteonit as a means to reduce the toxicity of the hydrazide of isonicotinic acid (isoniazid) at its introduction into the body for treatment of tuberculosis (Author svideteli, registered in the state register of medicines of the Russian Federation under number 90/111/2. However, litanic (lithium nicotinate) requires strict dosing is not recommended for long-term use. The task of the invention is to expand the range of tools that reduce the toxicity of the chemical and pharmaceutical drugs, in particular the hydrazide of isonicotinic acid (isoniazid), or diazona at its introduction into the body for treatment of tuberculosis. This task is solved by use of sodium salt of DNA from milk fish as a means to reduce the toxicity of chemically synthesized anti-TB drug. Fish ROE are cheap and available raw material for the production of sodium salt of DNA. Sodium salt of DNA from milk fish receive in accordance with the description of the patent of the Russian Federation 2072855 (IPC And 61 To 35/60, publ. 10.02.97 year). This technology involves the homogenization of the raw material in a solution of sodium chloride, processing homogenate solution of sodium salt of EDTA to a final concentration in the reaction mixture 3-30 mm, incubation of the homogenate in the presence of a proteolytic enzyme at 20-40oWith the m-separation and purification of the target product. Experimental studies on animals show that the sodium salt of DNA from milk fish reduces the toxicity of such chemically synthesized drugs, as isonicotinic acid hydrazide (isoniazid), or neason. In addition, this drug has immunomodulatory activity, is a powerful adaptogen and increases the body's resistance. Possible mechanisms of action of sodium salt of DNA in the body. From sources of scientific and technical information known to the immunomodulatory activity of preparations of DNA [1, 2, 3], which contribute to the induction of interferon in the body. When ingested, for example, by injection, sodium salt of DNA from milk fish decomposes under the influence of endonucleases in separate complexes: oligodeoxyribonucleotide and deoxynucleotide. Chronic infections, in particular tuberculosis, drain nucleotide balance in the body. Exogenous DNA provides restoration of balance deoxynucleotides in the body, thereby reducing the overall toxicity of the body. Thus, while the introduction of the organism (by injection) drug, possess is whether DNA from milk fish reduced the toxic effects of these drugs. Example. The sodium salt of DNA from milk fish as a means to reduce the toxicity of chemically synthesized anti-TB drugs drug neason. To confirm the antitoxic properties of the claimed preparation of sodium salt of DNA from milk fish used chemical composition of the drug Neeson with prolonged action, which includes isoniazid, methylcellulose (prolongator) and methyl ester of peroxybenzoyl acid (preservative). Drug Neeson, as with all chemicals, has toxic properties. Acute toxicity of Niazova was determined by indicators LD0(minimum tolerable threshold dose at which no mortality) and LD50(the dose that causes death of 50% of experimental animals). The experiments were conducted on 48 outbred white mice-males weight 18,0-20,0 g, divided into 6 groups of 8 animals each. The drug was administered once subcutaneously in increasing doses. Observation of the experimental mice were within 10 days. Study of acute toxicity of the drug neason on white mice following subcutaneous injection showed that LD0300 mg/kg LD16- 350 mg/kg LD500- 340 mg/kg LD16- 396 mg/kg LD50- 926 mg/kg LD84- 1108 mg/kg LD100- 1397 mg/kg The results of the experiments prove that the joint application of DNA from salmon ROE fish with bacteriostatic drug nasanam toxic effect of the latter is significantly reduced. Thus, the combined DNA preparations with bacteriostatic drugs can significantly reduce the frequency of adverse reactions and the development of drug resistance of Mycobacterium tuberculosis. Sources of scientific and technical information1. Rodionov, S. Y., Plyaskin K. P., Popov, I. L., Totkov S. I., Pak N.A., Weinberg Y. P. DNA Preparations in chemotherapy of neoplastic diseases // abstracts of the all-Russian conference "Tumor visceral localizations: early diagnosis, prevention, treatment". - Tomsk, 1995. - S. 192-193. 2. Alikin Y. C. Stimulants nonspecific resistance on the basis of RNA for veterinary medicine // Dis. Prof. of biological Sciences. - Novosibirsk, 1998. - 314 S. 3. Khaitov R.M P. M., Zemskov, A. M., Zemskov C. M. Dinucleotides and immunological disorders // Immunology. - 1996. 3. - S. 7-10. The sodium salt of DNA from milk fish in the quality of the preparations.
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