The method of treatment in children disease sheuerman-mau

IPC classes for russian patent The method of treatment in children disease sheuerman-mau (RU 2187308):

A61P19/08 - for bone diseases, e.g. rachitism, Paget's disease

A61K31/593 -

A61K31/455 -

A61K31/355 -

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(57) Abstract:

The invention relates to medicine. A method of treatment in children disease Chairman Mau, including additional nicotinic acid, vitamin E, askorutin and hyperbaric oxygenation. The method improves the processes of remodeling in bone and cartilage tissues. 2 C.p. f-crystals.

The invention relates to medicine, namely to orthopedics, and can be used for the treatment of early forms of disease Chairman Mau.

Known methods of treating disease Chairman Mau, her clinically significant forms of varying severity methods of surgical correction of deomali spine and use recliners corsets (J. L. Zivian, 1993; Viola S., et al., 1994). However, these methods are not suitable for the treatment of early forms of the disease.

The closest is a method of treating disease Chairman Mau using vitamin D, calcium supplements and anabolic hormones (Sou-dan Y. , 1968; H. Fichter,1970). However, this method of treatment is not pathogenic.

The objective of the invention is to propose a conservative way of pathogenetic therapy.

The problem is solved due to the fact that the medication switch is 0.53 times a day, course duration 25 days; perform hyperbaric oxygenation mode from 1.3 to 1.5 psi for 40 min, the course is 10 sessions; the total number of courses 2-3 intervals of 6-9 months. Drug treatment is performed on the background of physical activity in ascending mode for forming the adaptive capacity of the tissues of the spine in good posture. Treatments under the dynamic control of the processes of remodeling of bone and cartilage tissues, the balance of oxidant and antioxidant systems: biochemical study of calcium, phosphorus, hydroxyproline, glycosaminoglycans, alkaline phosphatase blood and urine, total oxidant activity, level of lipid hydroperoxides, malondialdehyde, catalase and superoxide dismutase.

When the task has a positive therapeutic effect, which is to improve processes remodeling of bone and cartilage tissue and the normalization of the oxidative status of patients, which can be judged by the parameters of biochemical tests in the dynamics. Pathogenetic treatment of patients in early preclinical stages of the disease will help to avoid surgical correction and disability of children.

The method is sleduyushzie, phosphorus, hydroxyproline, glycosaminoglycans, alkaline phosphatase blood and urine, which allows to judge about the intensity and balance of remodeling processes in bone and cartilage tissue, determination of total oxidant activity, level of lipid hydroperoxides, malondialdehyde, catalase and superoxide dismutase, which allow us to judge the balance between oxidant and antioxidant status of patients. On the study background have pathogenetic therapy (hyperbaric oxygenation mode from 1.3 to 1.5 psi for 40 min, the course is 10 sessions, the total number of courses 2-3, with an interval of 6-9 months. compensate for the oxygen deficiency in the tissues, enhances the reparative processes and trophic tissues, enhances the growth of capillaries at the injury site; calcium gluconate intravenous infusion of 10% to 10.0 and vitamin D₃at the dose of 100 ME per day for 10 days regulate the processes of remodeling in bone tissue. Askorutin at 0.53 times a day, tocopherol intramuscularly 10% - 1,0 within 10 days provide an antioxidant effect in the body tissues, nicotinic acid 1% -1,0 intravenously for 10 days improves oxidation-reduction reactions in the tissues of the body. Adequate exercise sposobstvuet is possible under laboratory control, correction therapy.

Clinical example. Patient N. A., 11 years, 276 medical history. Was admitted to the hospital 25.03.97. diagnosed with the Disease Chairman Mau, I stage. Upon receipt of a complaint of pain in the lumbar spine, worse during exercise. Ill for 2 years. On physical examination revealed a non-fixed kyphosis of the thoracic spine. On the radiograph in the "lying" is defined kyphotic deformity of the spine with the top-level disc Th_7-8the angle of deformation Kobu 35^o. Arc kyphosis length from Th₅to Th₁₀vertebrae, the vertebrae are of moderate clinoid shape, the contours of their closing plates fuzzy, usercity, not only in arc deformation, single schmorl's nodule. For biochemical analysis of blood and urine was observed in serum calcium concentration (mm/l) was 2.4 (2,0-2,6), phosphorus (mmol/l) and 1.4 (0.9 to 1.5), in the urinary excretion of calcium (mm/day) - 3,62 (0,95-2,55) and phosphorus (mm/day) and 23.1 (12,9-43,5); hydroxyproline serum (μm/l) -31,4 (13,39-16,41), its concentration in urine (µm/mg of the creative.) - 24,2 (17,78-20,86); glycosaminoglycans serum (μm/l) compared to 12.1 (5,50-6,46), the concentration of glycosaminoglycans in the urine (µm/mg of the creative.) - 5,81 (3,91-4,13); sulochna pidof (D & e) - 4,9 (3,3-3,5), malonic dialdehyde (µm/l) and 8.1 (1,8-2,0), catalase (U/b) - 591,3 (686,9-720,5), superoxide dismutase (U/b) - 8,9 (12,0-13,0). Biochemical indices testified violating processes remodeling of bone and cartilage tissue by strengthening them in the process of resorption, as well as the imbalance of oxidant/antioxidant system of the organism with deficiency of antioxidant defense. The complex of therapeutic measures, including hyperbaric oxygenation mode from 1.3 to 1.5 psi for 40 min, the course is 10 sessions, calcium gluconate 10% - 10,0, nicotinic acid 1% - 1,0 intravenously for 10 days, vitamin D₃at the dose of 100 ME per day for 10 days, askorutin at 0.53 times a day, tocopherol intramuscularly 10% - 1,0 within 10 days, adequate physical activity. After 14 days of starting treatment decreased pain, improved physical activity of the patient. In the study of blood and urine was observed in serum calcium concentration (mm/l) was 2.3 (2,0-2,6), phosphorus (mmol/l) and 1.4 (0.9 to 1.5), in the urinary excretion of calcium (mm/day) of 2.92 (0,95-2,55) and phosphorus (mm/day) - 26,1 (12,9-43,5); hydroxyproline serum (μm/l) - 21,4 (13,39-16,41), its concentration in urine (µm/mg of the creative.) - 22,2 (17,78-20,86); glycosaminoglycans serum (μm/l) is Ovi (cat. ) - 4,32 (2,62-3,71), total oxidant activity of plasma(%)- 15,1 (5,9-6,7), the gidroperekisi lipids (D & e) - 3,9 (3,3-3,5), malonic dialdehyde (μm/l) of 4.1 (1,8-2,0), catalase (U/b) -601,3 (686,9-720,5), superoxide dismutase (U/b) - 10,9 (12,0-13,0). Biochemical indices testified trends in process improvement remodeling in bone and cartilage tissues and strengthening the antioxidant activity of the organism: decreased excretion of calcium in the urine, the concentration of hydroxyproline, of glycosaminoglycans in the serum and highlights them with urine, decreased alkaline phosphatase activity and increased activity of antioxidant enzymes.

1. A method of treating disease Chairman Mau in children through the use of calcium, vitamin D₃, wherein the medical treatment comprises addition of nicotinic acid 1% - 1,0 intravenously, vitamin E (tocopherol) 10% - 1,0 intramuscularly, askorutin 0.53 times a day, the course duration is 25 days; perform hyperbaric oxygenation mode from 1.3 to 1.5 psi for 40 min, the course is 10 sessions; the total number of courses 2-3, with an interval of 6-9 months.

2. The method according to p. 1, wherein the medical treatment is performed on the background of physical activity in ascending mode is p. 1, wherein the treatment under the dynamic control of the processes of remodeling of bone and cartilage tissues, the balance of oxidant and antioxidant systems: biochemical study of calcium, phosphorus, hydroxyproline, glycosaminoglycans, alkaline phosphatase blood and urine, total oxidant activity, level of lipid hydroperoxides, malondialdehyde, catalase and superoxide dismutase.