edical or veterinary science and hygiene (A61)

A   Human necessities(304962)
A61            edical or veterinary science; hygiene(129366)
Combination for acne treatment and method of its application // 2614392
FIELD: pharmacy.SUBSTANCE: combination for acne treatment, comprising an aqueous Gynura Procumbens leaf extract, and means containing non-activated platelets and white blood cells in their own blood plasma. A method of acne treatment by application of the above combination.EFFECT: combination and treatment method are characterized by high efficiency in acne treatment.2 cl, 2 dwg

Immunity-inducing means // 2614386
FIELD: biotechnology.SUBSTANCE: invention refers to production of means containing at least one polypeptide selected from SEQ ID NO: 4, 2, 8, 10 and 12, and/or recombinant vector(s), comprising polynucleotide(s) encoding at least one polypeptide, as the active ingredient(s), and can be used in medicine. The resulting means is used for efficient induction of T-cell immunity against malignancies expressing KATNAL1.EFFECT: invention allows to obtain antigen-presenting cells presenting the polypeptide obtained from KATNAL1, and to effectively induce cytotoxic cells against KATNAL1, which is efficient as a therapeutic agent against malignant neoplasms expressing KATNAL1.7 cl, 3 dwg, 3 ex

Stable pharmaceutical composition for oral administration comprising levocetirizine, or pharmaceutically acceptable salt thereof and montelukast or pharmaceutically acceptable salt thereof // 2614382
FIELD: medicine, pharmacy.SUBSTANCE: this present invention relfers to a pharmaceutical composition in the form of a capsule for oral administration for asthma or allergic rhinitis prevention or treatment. The composition comprises: (a) the first fraction of particles in the form of mini-pill comprising levocetirizine, or pharmaceutically acceptable salt thereof and organic acid; and (b) the second fraction of particles in the form of mini-pill comprising montelukast or pharmaceutically acceptable salt thereof. The organic acid is citric acid, tartaric acid, succinic acid or ascorbic acid. The organic acid is present in the amount of 100 parts by weight per 100 parts of levocetirizine. The said first and second particle fractions are physically separated and filled into the capsule. A method for pharmaceutical capsule composition production is also described. The pharmaceutical composition of this invention inhibits the production of related contaminants of levocetirizine and montelukast and provides good stability.EFFECT: invention expands the product range of drugs for allergic rhinitis or asthma prevention or treatment.9 cl, 3 dwg, 4 tbl, 6 ex

Agent with antitumor activity based on arabinogalactan nanocomposites with selenium and methods for prepariation of such nanobiocomposites // 2614363
FIELD: pharmacy.SUBSTANCE: method of agent production includes interation of raw arabinogalactan and selenium dioxide or selenious acid salt in a solvent followed by precipitation in ethanol or acetone, or other organic solvent capable of mixing with water. The peculiarity of this method is that the process is carried out at the temperature of 20-25°C, stable selenium nanoparticles size is 0.5-250 nm, and raw arabinogalactan or arabinogalactan specially purified from phenolic impurities is used as the raw materila, while water or dimethylsulfoxide, or formamide are used as solvents.EFFECT: soluble stable nanocomposites providing antitumor activity, in dry form.3 cl, 7 dwg, 11 ex
ethod for hemorrhoidal foot processing during complicated internal hemorrhoids surgery // 2614362
FIELD: medicine.SUBSTANCE: hemorrhoidal feet processing is performed during surgical treatment of complicated internal hemorrhoids. A Luer clamp is imposed on the hemorrhoid tissue and the node feet is sutured proximally by an 8-shaped catgut ligature. Billroth forceps is imposed on a half of the foot and the node is undercut above it. The main suture is imposed with a node formed proximally to the retaining suture. An additional suture is imposed by the first injection of needle under the main ligature and second injection directly next to the stump in the direction of perianal skin. Node tissue is cut off after the last suture is applied. The third suture node is formed over the main ligature.EFFECT: reliable hemostasis during and after hemorrhoidectomy, reduced risk of postoperative submucosal hematomas and paraproctitis due to three 8-shaped stitches on the node foot during removal.3 dwg

ethod for cervix, vagina and vulva dystrophic diseases treatment by shockwave method and device for its implementation // 2614361
FIELD: medicine.SUBSTANCE: tissue with pathological changes is coated with fine particles of carbon dye. The coating is exposed to pulsed laser radiation. At the beginning of radiation, laser irradiation pulse power is set lower than the value expected for this threshold pathology. The repetition frequency of acoustic pulses generated by a surface thermal microexplosion and absorbing the laser emission of carbon dye particles is determined. It is compared to the laser pulses frequency. Laser pulses power is sequentially increased to a value at which the acoustic pulse frequency becomes equal to the repetition frequency of laser pulses. Irradiation is performed with this pulse power value. The device includes a laser operating in a pulse-periodic mode of laser radiation generation, a laser radiation operating parameters control unit, a laser radiation parameters measuring unit and an indication unit. It additionally contains an acoustic microphone, a selectable band-pass filter for a maximum range of 5-7 kHz, microphone signal amplifier and a two-input coincidence circuit, all connected in series. One of the coincidence circuit inputs is connected to the microphone signal amplifier output, the second icoincidence circuit input is connected to the laser pulses repetition driving frequency generator output, and output - to the laser radiation operating parameters control unit input and the indication unit.EFFECT: increased efficiency of treatment and reduced probability of postoperative recurrence and scar development processes through implementation of objective selection and monitoring of the adequacy of defined laser radiation parameters, providing the process of shock wave destruction.2 cl, dwg
Treatment method of haematogeneous osteomyelitis of vertebral column // 2614360
FIELD: medicine.SUBSTANCE: invention may be applied for the treatment of the haematogeneous osteomyelitis of the vertebral column. A porous implant, inside which a perforated drainage is mounted, is installed into a bone defect of vertebrae. Elimination of a pyoinflammatory exudate from the affected area is performed by means of vacuum at (-0.1)-(-0.2) mPa within 7-10 days.EFFECT: method allows improving efficiency of the drainage of the bone cavity and epidural space during the treatment of the haematogeneous osteomyelitis of the vertebral column.4 dwg, 1 tbl
Gas generator for therapeutic application // 2614359
FIELD: medical equipment.SUBSTANCE: group of inventions relates to medical equipment. Gas generator for therapeutic application comprises device for electrolysis for electrolysis of water and formation of gas mixture, which contains hydrogen and oxygen. Gas generator for therapeutic application also has system for gas mixing, connected to device for electrolysis, containing gas mixture. System for gas mixing is intended for mixing of gas mixture with water vapor, sprayed medicinal fluid, volatile ether oil or their combination in order to form therapeutic gas inhalation for user.EFFECT: group of inventions improves patient's relaxation in treating.14 cl, 3 dwg

Absorbent product with set of sensors for detection of body excretions // 2614331
FIELD: hygiene.SUBSTANCE: absorbent article is disclosed. It comprises main part (32) comprising outer shell (40) with inner surface and outer surface, and absorbent structure (44), adjacent to outer shell inner surface. Device also has set (104) of contactless electronic sensors containing gas sensors, each of which is capable of separately monitoring level of concentration of gas, associated with specific volatile compound, wherein set of contactless electronic sensors monitors levels of concentration of gases, released as a result of inflow into absorbent product of contaminants in form of two or more volatile compounds. It also comprises controller (106), configured to detect changes in levels of gas concentration exceeding, as a result of inflow into absorbent product of contaminants in form of urine and/or defecation products, limit levels of gas sensors in set of contactless electronic sensors. Device also comprises signalling device (110) to notify user on controller detected changes in concentration of gases.EFFECT: alternative version of absorbent device and signalling device used in above absorbent products are also disclosed.20 cl, 6 dwg

Absorbent product // 2614325
FIELD: hygiene.SUBSTANCE: absorbent product can minimize amount of body excretions in contact with skin of carrier, and can minimize leakage frequency of body excretions from absorbent product. Absorbent product comprises front material in relation to body including first main surface and second main surface, second main surface is opposite to first main surface; liquid-impermeable outer coating and absorbent base containing front surface in relation to body, front surface in relation to clothing article, first longitudinal side edge and second longitudinal side edge, wherein second longitudinal side edge is opposite relative to first longitudinal side edge, front material in relation to body is at least partially wrapped around absorbent base so, that front material in relation to body is located above at least part of front surface of absorbent base in relation to body surface, passes around at least one of first longitudinal side edge and second longitudinal side edge of absorbent base and passes under at least part of front surface of absorbent base in relation to clothing article, where at least some front material relative to body running under front surface of absorbent base in relation to clothing article is in contact with front surface of liquid-impermeable outer coating in relation to body, where front material in relation to body is fabric of material subjected to jet fastening and includes multiple projecting parts extending from one of first and second main surfaces.EFFECT: absorbent product, characterized by improved retention of excretions of human organism.25 cl, 66 dwg, 16 tbl

Packaging // 2614324
FIELD: packaging industry.SUBSTANCE: packaging comprises form-stable twisted collagen carrier which contains a collagen layer and a coating layer containing thrombin and fibrinogen, and is characterized by the shape of the elongate member with a number of turns of the collagen carrier around the longitudinal axis of the elongate member with at least one external coil(s) oriented so that the coating layer forms an outer surface of each of the said external coil(s). Packaging comprises a portion made as a tank with a compartment which contains at least one portion of the twisted collagen carrier. The compartment comprises a hole in the upper surface of the portion made as a tank and at least one cavity disposed at the edge of the hole. The said cavity opens into the compartment and the upper surface.EFFECT: secure storage and retrieval of brittle twisted collagen carrier without damage to the coating.27 cl, 9 dwg
ethod for preparation of collagen product // 2614273
FIELD: pharmacy.SUBSTANCE: invention refers to processing and cosmetics industris, namely to a method for production of a collagen product with the following characteristics: reception of skins of freshwater fish such as silver carp, carp, grass carp, mirror carp, manual or machine cleaning from scale, muscle tissue, fins and mechanical impurities, washing for 30 minutes in drum type machines with a solution of soap and then in water - to remove residual soap, the rinsed skins are subjected to peroxide and alkaline treatment, for which they are poured with a mixture of hydrogen peroxide with mass concentration of 3% and sodium hydroxide with mass concentration of 3 % and kept at 20-25°C for 1.5-2 hours and liquor ratio of 1:4, the treated skins are washed with flowing water at 8-12°C for 10-15 min, then the skins are poured with citric acid solution with mass concentration of 6% and kept for 6 days, the resulting mass is homogenized, packaged in polyethylene and stored at 0…+4°C for° max. 4 months.EFFECT: increase of collagen product quality indicators: increase in collagen output, improved organoleptic properties, reduced complexity and cost by reducing the number of process steps and reagents, intensification of the pre-treatment process and raw materials degreasing.1 tbl, 2 ex
ethod for brain protection in case of carotid reconstruction during acute ischemic stroke // 2614270
FIELD: medicine.SUBSTANCE: degree of the internal carotid artery (ICA) stenosis is determined and the initial blood pressure (BP) is measured. If the degree of ICA stenosis on the stroke side is up to 79% or in case of contralateral ICA occlusion and initial systolic blood pressure (SBP) less than 150 mm Hg, the main stage of surgery is arterial bed clamping, common carotid artery (CCA) longitudinal dissection with transition to the ICA, temporary internal bypass (TIB) installation, arteriotomical hole suturing, TIB removal and blood flow restoration in the carotid arteries, is performed at SBP level of 100-120 mm Hg, and if the initial SBP is 150 mm Hg and more - the main stage of surgery is carried out at SBP level of 120-140 mm Hg. If the degree of ICA stenosis on the stroke side is 80% or more, the main stage of surgery is arterial bed clamping, CCA dissection with transition to the ICA, arteriotomical hole suturing, TIB removal and blood flow restoration in the carotid arteries, is performed at SBP equal to the initial SBP plus 30%, but no more than 160 mm Hg.EFFECT: invention reduces intraoperative complications, which is achieved by SBP regulating depending on the degree of stenosis.2 cl, 1 dwg, 3 ex

Stable liquid pharmaceutical preparations of fused protein tnfr: fc // 2614257
FIELD: medicine, pharmacy.SUBSTANCE: invention refers to biotechnology, namely to stable pharmaceutical compositions of fused protein TNFR: Fc. Pharmaceutical compositions and kits for their application of different physical stability TNFR:Fc are obtained by using the citrate buffer system at a concentration of 25 to 120 mM and amino acid selected from the group consisting of proline and lysine, and their pharmaceutically acceptable salts at a concentration of 15 to 100 mM as a stabilizer.EFFECT: invention allows stability of pharmaceutical compositions of etanercept for long-term storage.50 cl, 1 dwg, 17 tbl, 3 ex

Alpha-v beta-8-binding antibodies // 2614252
FIELD: pharmacy.SUBSTANCE: antibodies with high affinity for β8-subunit αvβ8 proposed. Pharmaceutical composition comprising such antibodies, and methods of their application are also described. The proposed group of inventions can be used in medicine.EFFECT: improved antibody properties.23 cl, 14 dwg, 19 ex

Osteotropic radiopharmaceuticals for pet imaging // 2614235
FIELD: medicine.SUBSTANCE: invention relates to the field of nuclear medicine, namely to radiopharmaceuticals (RF) for metastatic bone lesions imaging using the positron emission tomography (PET) techniques and radiation therapy planning. This goal is achieved by application of a composition representing a solution containing gallium-68 in the form of a complex with oxa-bis (ethylene-nitrile)tetrametylene-phosphonic acid and sodium chloride, sodium hydroxide and a phosphate buffer containing sodium phosphate and sodium hydrogen phosphate, as the preparation for PET imaging of metastatic bone lesions and radiation therapy planning. Preparation is obtained from a lyophilized composition at the room temperature during 1-2 minutes, radiochemical purity of the preparation is more than 90%, pH range is from 4.5 to 8.0, maximum accumulation of drug in a pathological bone shall be reached 1.5 hours after introduction, and is 40-45% of the introduced activity, differential callus/blood accumulation factor is more than 10, accumulation of the drug in blood is less than 0.30%/year.EFFECT: invention expands the number of nuclear medicine devices, particularly for metastatic bone lesions imaging using the positron emission tomography (PET) techniques and radiation therapy planning.3 dwg, 4 ex, 1 tbl
Pharmaceutical composition based on 3-(4-methylimidazole-1-yl)imidazo[1,2-b][1,2,4,5]tetrazine as anti-tumor agent // 2614234
FIELD: pharmaceutics.SUBSTANCE: invention relates to pharmaceutical industry and includes pharmaceutical composition, which is solution of pharmaceutically acceptable substance 3-(4-methylimidazole-1-yl)imidazo[1,2-b][1,2,4,5]tetrazine of formula (I) and D-mannitol in water. Composition is used for therapy of malignant tumors in human or animal.EFFECT: technical result is obtaining stable, long-term stored solution of Substance 1.1 cl
ethod for cognitive impairment detection for persons of young and middle age // 2614222
FIELD: medicine.SUBSTANCE: testing is conducted by the "Concepts Exception" method for different age categories, recording the number of correct answers, time spent on the answers, and determining the thinking level integral index by the formula where Ind is the thinking level integral index; N is the number of correct answers in the test; t" is the time in seconds required for testing.EFFECT: method allows to identify human cognitive dysfunction by evaluating the integral index of the thinking level.4 tbl, 3 ex

Tube holder for irrigation system or silicone feeding systems for vitreoretinal surgery // 2614221
FIELD: medicine.SUBSTANCE: tube holder for irrigation system or silicone feeding systems for vitreoretinal surgery comprises a base with at least two longitudinal slots on the bottom surface, one with the minimum width of 10.0 mm and the other with the minimum width of 5.0 mm, depth of each slot is not less than 5.0 mm. The base between the slots has a through threaded hole with a stand screwed in from the side opposite to the base slots with a free end in the form of an arc, located above the base. The free end of the arc is spirally twisted with a pitch greater than the diameter of the tube with the irrigation system or silicone delivery system cannula.EFFECT: use of this invention allows to support and maintain a stable position of the fluid supply system and, accordingly, cannula position in the port.3 dwg, 1 ex
ethod of audiological diagnostics of perilymphatic fistulas of labyrinth in sensorineural hearing loss // 2614220
FIELD: medicine.SUBSTANCE: identification of sound lateralisation is performed with fork tined placed on patient's forehead centre or bridge of nose by "pinch" method. Audiometric control of patient's hearing acuity is performed with determination of initial thresholds of patient's sound perception by air conductivity on the entire tone-scale. Audiometric control of patient's hearing acuity is performed with determination of initial thresholds of patient's sound perception by bone conductivity on the entire tone-scale. After that, patient presses their head to sternum maximally tightly and keeps their head in such position for 55-65 seconds to ensure partial compression of their neck veins and to increase tension of meninges. It is accompanied by 30-50 mm of water column increase of liquor pressure. Immediately in patient determined is fact of presence or absence of change of their thresholds of sound perception by air conductivity on tone-scale at different frequencies of sounding. After that, when patient is in horizontal position on their back with their head turned on healthy ear, acoustic duct of affected ear is filled with inert liquid which has temperature equal to temperature of patient's body. Thresholds of patient's hearing are re-determined by bone conductivity. If after pressing head to sternum thresholds of patient's sound perception by air conductivity increases by 10 dB and more at not less than two different frequencies of sounding with simultaneous absence of tuning-fork lateralisation of sound into healthy ear and if threshold of sound perception by bone conductivity reduces in patient by 10 dB and more on not less than two different frequencies of sounding after filling acoustic duct of affected ear with inert liquid, presence of perilymphatic fistula of labyrinth is diagnosed in patient.EFFECT: method makes it possible to carry out reliable diagnostics of presence of perilymphatic fistulas of labyrinth independently on mechanism of their development, and reduce diagnostics time due to complex estimation of patient's sound perception by aie and bone conductivity.3 ex
ethod of posterior interbody fusion // 2614219
FIELD: medicine.SUBSTANCE: invention refers to the traumatology and orthopedics and may be used for posterior interbody fusion. Channels in the intebody space is formed with maintaining of integrity of the endplates of adjacent vertebral bodies. An autotransplant of bone chip formed during conduction of interlaminectomy, facetectomy, or decompression of spinal cord roots is formed by means of expression of the liquid fraction of a bone mass and compression until formation of a supportable bone column of an intended size. The implant of porous titanium nickelide is installed into the channel in such way to provide maintaining of support ability of the autotransplant.EFFECT: method of posterior interbody fusion allows quickening of formation of a bone and metal block.
ethod for rear retroperitoneal adrenalectomy perfomance // 2614218
FIELD: medicine.SUBSTANCE: rear retroperitoneoscopic adrenalectomy is performed through an incision to 30 mm under the 12th rib end. The workspace is created using an endoscope tube. Along the wound edges two punctures for the endoscope and working tool are made. Detection of adrenal gland tumours is performed. First, the lower part of the adrenal gland, then the side surfaces are subjected to mobilization, then the adrenal gland central vein is suppressed, and the rear surface is mobilized. The upper part is the last to be suppressed.EFFECT: method eliminates the costly special equipment, reduces pain in the postoperative period and provides a good cosmetic effect due to operation according to a specially developed algorithm of adrenal gland selection from the surrounding tissues.4 cl, 1 tbl, 2 ex

Device for puncture cyto- histo biopsy of parenchymal organs cancer // 2614217
FIELD: medicine.SUBSTANCE: device includes a conducting needle with centimetre marks a working needle with a Quincke form cut and an echogenic tip for better control of the introduction depth, and a recess for tissue sample gripping, it is characterized by the conducting needle having a non-toxic polyethylene coating and a connector for a syringe at the distal end, and 6 holes for tumour cells aspiration are located spirally at an angle of 120°.EFFECT: improved accuracy and reliability of morphological diagnosis of cancer.1 dwg

Endovascular delivery system for aortic heart valve prosthesis // 2614216
FIELD: medicine.SUBSTANCE: endovascular delivery system for the aortic heart valve prosthesis consists of the working tube with a handle with controls at the proximal end, and a conical tip and a protective cover at the distal end, the cover contains an inner holder to accommodate the aortic heart valve prosthesis. The conical tip comprises three longitudinal slots, each having a fastener in the form of a hollow tube. The radial groove formed at the tip, has an annular spring configured to compress the fasteners. The spring is fixed with at least three brackets located between the longitudinal slots; the working tube wall has at least three longitudinal channels, each containing a wire to connect the working tube and fastener with the aortic heart valve prosthesis frame. One end of each wire is fixed by a control and the other is intended for fixation of the aortic heart valve prosthesis frame fastener. At the proximal end of each clamp an U-shaped slot is made for release connection of wire stretched within the retainer with the aortic heart valve prosthesis frame fastener, the fasteners are fixed annularly inside the conical tip body.EFFECT: provision of controlled aortic valve prosthesis implantation.2 cl, 6 dwg
Low-invasive method for elimination of isolated residual adduction of anterior part of foot in case of equino-varo-adduction deformation of feet in children // 2614215
FIELD: medicine.SUBSTANCE: method includes performance of longitudinally lateral cut in projection of 5 metatarsal bone, reaching tendon of peroneus brevis. Tendon is cut off with cortical plate. Bed is formed on the base of 5 metatarsal bone. Free end of tendon of peroneus brevis with cortical plate is placed into bed, and cortical plate is fixed to metatarsal bone in position of foot deformation correction. It is advisable to shape cortical plate in form of polygon, and to shape bed on the base of 5 metatarsal bone if form of the same polygon as cortical plate.EFFECT: method prevents postoperative complications and fixes tendon to bone in more reliable way.4 cl, 3 dwg, 1 ex

Device for measurement of intraocular lenses support haptics elastic properties // 2614214
FIELD: medicine.SUBSTANCE: device for measurement of intraocular lenses supporting haptics elastic properties includes a base with a tripod, with a horizontal cantilever bar installed with a possibility of moving and fixation. At the end of the bar, a head is located with a tapered tip interacting with the measured element, on the opposite side of which another conical tip is arranged with displacement, and a measuring device associated with the measured element. Between the first bar and the base, an additional bar is fixed made of two parts: one is fixed on the tripod with a possibility of movement and fixing thereon, the other has the form of a plate mounted with a possibility of movement relative to the first part. The plate has holes for accommodation of the measured elements, represented by intraocular lenses. The head with a conical tip is provided with an assembly for dosed movement in the direction of the measured element, and scales are used as the measuring device.EFFECT: application of this invention allows to determine the quality of the intraocular lenses supporting haptics elasticity.2 dwg, 1 ex, 1 tbl

ethod for proximal gastrointestinal transplant blood circulation improve in case of esophagoplasty // 2614213
FIELD: medicine.SUBSTANCE: esophagus is formed by the isoperistaltic stem from the greater stomach curvature retaining the right gastro-omental artery. Ligation and intersection of three branches of the right gastric gastro-omental artery are performed. First, the gastric branch of the right gastro-omental artery is transected at a distance of 5-6 cm from the pylorus. Subsequent artery branches are ligated and transected preserving at least two branches between them.EFFECT: improved blood supply of the proximal transplant in case of total replacement of diseased esophagus.1 dwg

Suture material // 2614212
FIELD: medicine.SUBSTANCE: suture material contains a thread/(threads) of the superelastic NiTi. The suture material structure further includes a thread/(threads) made of an alloy with the following composition: 45% of titanium, 0.5% of molybdenum, 1.5% of iron, the rest - nickel. The diameter of the applied threads is selected from the range of 30-60 microns.EFFECT: increased handling quality of the suture material.3 dwg
eans for fixation of tissues connected during surgery // 2614211
FIELD: medicine.SUBSTANCE: fixation means is made of a cord material based on knitted fabric of nickel alloy and titanium thread. The means has the form of a ribbon, formed by cord material laying by several layers flattened to contact and layer binding along edges with each other.EFFECT: increased possibility of intraoperative monitoring of tightening effort adequacy and reduced local pressure and underlying tissues atrophy.5 dwg
ethod for bifixation and stereoscopic vision recovery at early stages of concomitant strabismus conservative treatment, and visual fields separator for method implementation // 2614210
FIELD: medicine.SUBSTANCE: method for bifixation and stereoscopic vision recovery at early stages of concomitant strabismus conservative treatment, which includes application of liquid crystal glasses, visual exercises to restore the fusional ability to merge on sinoptofore and/or visual fields separator, exercises to restore the binocular vision, according to the invention, preliminary inspection is conducted to reveal causality of strabismus with involvement of a neurologist and vertebrologist, therapeutic and rehabilitative measures to address the identified causes, the visual function is activated without strict separation of the right and the left eye visual fields, using liquid crystal glasses, partial blocking of objects visible by the better seeing eye and/or alternate blocking of the right and the left eye is provided, application of the direct occlusion is limited by 1 hour per day, and bifixation training on the visual fields separator starts at a distance of 5-7 cm from the eye, with development of fusional merging reflex with gradual distance increase up to 50 cm. The visual fields separator, which includes a separating bar and a transverse frame installed thereon for object placement, according to the invention, the transverse frame is movable along the separating bar. EFFECT: group of inventions allows to increase the efficiency of concomitant strabismus treatment at an early age. 4 cl, 3 dwg
ethod for glossalgia physical therapy // 2614209
FIELD: medicine.SUBSTANCE: mesodiencephalic modulation is performed. Pulse stimulation currents with a carrier frequency of 10,000 Hz, modulated in the low frequency range, varying from 20 to 100 Hz in a single session is used. current supply power changes from 0.5 to 4 mA during a session. The duration of each session is 30 minutes. The procedures are daily. During the first 3 days, two procedures are performed with a minimum interval of 6 hours, later - one procedure per day. The therapeutic course is 13 procedures.EFFECT: method provides relief of pain and paresthetic feelings, restoration of normal sensation and tissue viability function, improved microcirculation and oxygenation.3 ex

Anchor for legiment and muscles reinsetion in case of their separation from bones and key for installation and removal // 2614208
FIELD: medicine.SUBSTANCE: anchor for legiments and muscles reinsertion in case of separation from the bone comprises a threaded cylindrical portion and a head for the anchor installation and removal key, with hole and slots in the thread on both sides. Grooves are made along the entire length of the thread, a suture hole extends perpendicularly to the side surface and connects slots in the middle part, the key head has a cylindrical shape with flats at the grooves in the thread. The key for installation and removal of the above anchor is T-shaped and includes a handle and a rod. The working end of the rod is a stepwise cup, two opposing recesses are arranged on the lower step, coming from the edges of the rod to the handle. The recess height exceeds the anchor head height by 1 mm, while the walls of the lower cup step are flat from the inside at anchor head flats. The side wall of the rod contains an inclined channel extending to the upper step of the cup for suture withdrawal from the rod cavity, the channel outlet opening is located in a plane perpendicular to the side recesses plane.EFFECT: structural strength to secure the suture, suturing without any contact with the cutting edge of the anchor.2 cl, 6 dwg

ethod of treating chronic elbow and prepatellar brusitis // 2614207
FIELD: medicine.SUBSTANCE: invention relates to medicine, namely to traumatology-orthopedics and surgery, and can be applied for treatment of chronic elbow and prepatellar brusitis. For this purpose puncture of bursa, its content aspiration, introduction of medication in its cavity, drainage of bursa with constant active aspiration are realised. As medication 2 ml of heparin 10000 IU are introduced in bursa cavity. After 24 hours aspiration of content is carried out and 2 ml of heparin 10000 IU and 10 mg of trypsin are introduced. 3 hours after this vacuum system of active aspiration is placed in bursa cavity. Further, in a day removal of aspiration liquid from system is realised in the process of bandaging. System of active aspiration is applied until exudate extraction from bursa stops.EFFECT: method ensures improvement of treatment effects as a result of reduction of pain reaction to medicinal procedure, reduction of quantity of recurrences as a result of active influence on synovial envelope of bursa, thorough evacuation of its content and activation of regeneration processes.1 dwg, 2 ex
ethod for myocardial revascularization in case of coronary artery disease // 2614196
FIELD: medicine.SUBSTANCE: combined effect on the myocardium is provided, including laser treatment and intramyocardial administration of autologous bone marrow stem cells (ABMSC). Through channels in the left ventricular wall in the myocardial ischemia area or areas are performed, with diameter of 0.3-1.0 mm and frequency of one channel per 1 cm2 of the left ventricle wall. Each channel is perpendicular to the left ventricle outer wall surface in the channel forming area. Channels are formed using the impact of CO2 laser, with a power of 800-1000 W and pulse duration of 20-50 ms. The pulse duration is chosen sufficient to form a channel by one pulse within the refractory period of the cardiac cycle. Then, 200 l of a solution containing 8.3 million of ABMSC is administered around each channel along its entire length using one injection. The needle is directed in the avascular zone at a distance of 1-2 mm from the outer channel wall. ABMSC is introduced when extracting the needle.EFFECT: reduction of intervention trauma, while maintaining its efficiency, reducing the volume of fluid injected with ABMSC, as well as application of one pulse to form a through channel in the myocardium, prevention of intraoperative complications and induced arrhythmia due to the laser pulse impact by forming channels in the myocardium within the refractory period of the cardiac cycle.1 ex

Reduction of level of lactate and increasing of production of polypeptide by inhibiting expression of lactate dehydrogenase and pyruvate dehydrogenase kinase // 2614125
FIELD: biotechnology.SUBSTANCE: invention relates to biotechnology and concerns method of reducing lactate production in mammalian cells, method of silencing or reduction in mammal cell of transcription of lactate dehydrogenase (LDH) and pyruvate dehydrogenase kinase (PDHK), method of producing mammal cells, which exhibits low production of lactate in culture, vector containing first heterologous nucleotide sequence coding small interfering RNA (siRNA), specific for lactate dehydrogenase, and second heterologous nucleotide sequence coding siRNA specific for pyruvate dehydrogenase kinase, each of which is connected with its promoter.EFFECT: presented inventions allow reducing in cultured cells production of lactate and increasing of production of heterologous polypeptide.40 cl, 6 dwg
ethod for producing a complex shigellosis drug // 2614123
FIELD: pharmacy.SUBSTANCE: method involves mixing of equal weight amounts of modified lipopolysaccharide Shigella flexneri 2a and exopolysaccharide Shigella sonnei in the buffered solution of the following composition: 0.2 M NaCl, 0.05 M Tris, 0.25% sodium deoxycholate, pH 8.3, at 80°C, followed by dialysis against the same buffered solution without sodium deoxycholate and then against deionized water followed by lyophilization. In this case the modified lipopolysaccharide Shigella flexneri 2a lipid A is partially O-deacylated. The said modified lipopolysaccharide Shigella flexneri 2a is obtained as a result of selective alkaline hydrolysis of the original lipopolysaccharide Shigella flexneri 2a.EFFECT: invention provides a drug with low toxicity, high efficiency and bimodal specificity.2 dwg, 3 tbl, 5 ex

ethod of producing human immunoglobulin // 2614119
FIELD: biochemistry.SUBSTANCE: invention relates to biochemistry. Group of inventions is described, which involves method of producing human immunoglobulin and preparation of human immunoglobulin, obtained using said method. Method includes stage of dissolving of Cohn component I+II+III or Cohn component II+III in water for injections; deposition with caprylic acid or caprylate; first stage of anion-exchange chromatography, involving bringing pH of filtrate obtained at step (2), to 5.2, cleaning by anion-exchange chromatography and obtaining eluating solution; deposition of IgM, including control of conductivity of eluating solution obtained at step (3), up to 500–1,000 µS/cm by means of water and further bringing pH to 6.0–7.3,with subsequent settling for 1–2 hours, filtration and filtrate collection; second stage of anion-exchange chromatography, involving bringing pH of filtrate obtained at step (4) to 5.6, subsequent purification by anion-exchange chromatography and collection of eluating solution; production of human immunoglobulin by dialysis of eluating solution obtained at step (5), by ultrafiltration, obtaining pharmaceutical form and inactivation of viruses.EFFECT: invention extends range of methods for producing human immunoglobulin.9 cl, 2 dwg, 3 tbl, 2 ex

Recombinant somatostatin-containing protein, method for production, injecting drug to increase meat and dairy efficiency of agricultural animals, and method for drug application // 2614115
FIELD: biotechnology.SUBSTANCE: recombinant immunogenic protein comprising somatostatin and glucosan-binding domain. The method for protein production on glucosan is presented, which includes protein binding to the glucosan-containing sorbent due to affinity interaction, followed by washing of unbound bacterial proteins and isolation of the desired product. An injected preparation based on the protein is also described. A method for farm animals muscle mass and milk production increase is described comprising conducting twice subcutaneous or intramuscular drug injection. The invention allows to obtain a recombinant somatostatin-containing immunologically active protein, easy to purify and having sufficient immunogenicity against somatostatin.EFFECT: invention can be used to increase meat and milk production of farm animals by induction of synthesis of specific antibodies to somatostatin, blocking of its action, and as a consequence, anabolic processes enhancement in animals.4 cl, 3 tbl

Bacteriophages, phage peptides and methods for application thereof // 2614114
FIELD: biotechnology.SUBSTANCE: invention relates to biotechnology and virology. Described is bacteriophage F510/08, comprising genome, which contains nucleic acid sequence SEQ ID NO: 4. Bacteriophage shows activity upon Pseudomonas aeruginosa. Invention also describes versions of pharmaceutical composition containing such bacteriophage, and methods of therapy for treatment and prevention of bacterial infection.EFFECT: presented group of inventions can be applied in medicine.23 cl, 327 dwg, 7 tbl, 7 ex

Self-destroying and self-locking syringe // 2614109
FIELD: medicine.SUBSTANCE: invention refers to medical equipment, namely to self-destroying and self-locking syringes. Syringe comprises body with taper tip accommodating piston with seal and cross-shaped rod connected to each other by means of joint unit, which includes hollow stand with square cross-section located in center of piston on non-working side with grippers extending from its side walls in form of symmetric diverging elastic lobes, in upper part of which there are shaped holes, and lower part of cross-shaped rod enters hollow stand with allowance for stroke and comprises also needle processes symmetrically arranged in side planes directed upwards at acute angle to rod, shape and height of location of which match height of location of profiled holes of piston lobes, wherein on working side of piston shell is fixed with rapid hardening glue, which has in its center form bent upwards with thinned bottom wall, and upper part of conical tip is rounded and has shell breaking studs.EFFECT: use of invention provides higher reliability of its disposable at simple design and minimum changes in modern technology of syringes’ manufacturing.1 cl, 1 dwg
ethod for surgical management of ocular hypotony as complication following fistulising antiglaucomatous operations // 2614108
FIELD: medicine.SUBSTANCE: surgery is carried out in two stages: first, fistula is packed, at that, paracentesis is performed from the inside, from the front chamber, the front chamber is filled with viscoelastic, then a Tenon's membrane fragment is cut off, directed to the front chamber and then directed into fistula with a tool under gonioscopic supervision to provide initial fixation of the fragment. Next, the tool is changed to irrigation trabeculotome. The final fragment fixation in the fistula is performed by directing the trabeculotome irrigation jet. Transition to the second stage is performed: trabeculotomy is performed ab interno for 3-4 hours using the irrigation trabeculotome. The diameter of the excised Tenon's membrane fragment exceeds the fistula diameter. Trabeculotomy ab interno can be either intermittent or continuous. Trabeculotomy ab interno is performed to one and the other side of the sealed fistula zone or on one side. Irrigation trabeculotome is a modified 25G caliber injection needle supplying irrigation solution, and the working part is provided with lateral double-edged cutters. The distal end of the needle is made blunt. If choroidal detachment is observed after fistula packing and trabeculotomy, the suprachoroidal space is drained with outward fluid discharge.EFFECT: method ensures stable normalization of intraocular pressure reduced operative and postoperative complications, achievment of high visual acuity.6 cl, 1 ex
ethod of minimally traumatic autopsy // 2614107
FIELD: medicine.SUBSTANCE: invention relates to field of medicine, namely to pathological anatomy. At the beginning of autopsy through semilunar access facing jugular notch neck organs are separated to upper opening of chest with successive application of device for separation of muscles of mouth diaphragm muscles, device for transection of neurovascular bundle of neck, device for gripping epiglottis, device for gripping soft tissues of neck and their extraction. After that, through upper-medial access with application of yard retractor or Segal retractor organ-complex, consisting of organs of digestive and genitourinary system, is separated as a single unit, if necessary complexes are separated one by one, for which purpose intestine and spleen are preliminarily mobilised and separated. After that, separation of neck and chest organs is completed, with successive application of device for lifting rib arch, device for transection of major neurovascular bundle of neck, device for separation of neck organs from cervical spine, device for gripping epiglottis, device for gripping soft tissues of neck and extraction of neck organs.EFFECT: method makes it possible to optimise autopsy process due to facilitation of separation of organ-complexes, improvement of visualisation of body cavities at all stages of autopsy, facilitation of sampling material for histological and bacteriological analysis in case of inflammatory processes in thoracic cavity, reduction of autopsy duration, increase of preservation of anatomical integrity of skin and tissues of internal organs of corpse.

ethod for articular syndrome assessment in case of knee osteoarthritis and device for its implementation // 2614106
FIELD: medicine.SUBSTANCE: tensoalgimetry (TA) is performed in the knee joint projection, TA indicators of the medial vastus, semitendinosus, biceps femoris, gastrocnemius muscle are measured at the four points of the diseased and healthy knee joints. In addition, the flexion and extension force, flexion and extension angle and the circumference of the diseased and healthy knee joints are measured. Using the obtained values, according to the claims, the integral joint component (IJC) is determined before and after treatment and the increase ratio is calculated as the difference between the initial and final IJC values as a percentage. According to the increse ratio, articular syndrome is estimated. The device for tenderness and strength measurement in the knee joint comprises a force sensor with nozzles for tensoalgimetry and dynamometry, a measuring unit. The force sensor is a cylinder with an internal tension gauge, which transmits the measured force through the rod. Nozzles have sizes corresponding to the measurement areas.EFFECT: inventions group ensures accurate assessment of articular syndrome, treatment efficiency, reduced research time, expansion of device technical capabilities.2 cl, 6 dwg, 3 ex
ethod for macular edema treatment for patients with retinal vascular disease // 2614105
FIELD: medicine.SUBSTANCE: laser retina coagulation is carried out in the form of subthreshold "focal lattice" in combination with medication, comprising administration of 0.3-0.5 ml of dalargin under the conjunctiva or parabulbarly for 5-10 days after laser coagulation. Additional administration of 0.3-0.5 ml of dalargin under the conjunctiva or parabulbarly is performed for 5-10 days prior to laser coagulation. Vessel Due F 600 LE is also introduced intramusculary for 10 days prior to laser coagulation and Vessel Due F 250 LE or Sulodexide 250 LE is administered orally 2 times a day for 30 days after laser coagulation.EFFECT: method allows to increase the efficiency of macular edema treatment for patients with retinal vascular disease.17 dwg, 3 ex

Cryoprobe // 2614104
FIELD: medicine.SUBSTANCE: cryoprobe comprises a housing, a hollow needle mounted in the housing, with an open proximal and a closed distal end, supply and return tubes. The supply tube is L-shaped, with open proximal end fixed in the housing, and open distal located in the needle cavity. The supply tube contains a portion tapering towards the distal end with an upstrean shunt branch, the open end of which is fixed in the housing. The open distal end of the return tube is located in the needle cavity with a cryochamber foemed at the closed distal end of the needle, the chamber is bounded by the inner surface of the needle and tightly separated from the cavity formed between the inner surface of the needle and the outer surface of the return tube and communicating with the housing interior. Downstream to the bending, the supply tube portion is located within the return tube, and the distal end of the supply tube goes into the cryo-chamber. The proximal end of the return tube is tightly connected to the supply tupe along the outer surface of the tube. The return tube has a drain branch, with the open end fixed in the housing.EFFECT: invention application can improve the efficiency of cryoprobe operation by liquid refrigerant fraction delivery to the needle cryo-chamber and improvement of thermal insulation at the non-working portion of needle and housing during cryoprobe operation, simplify the design.3 cl, 1 dwg
Drainage for intrascleral outflow of intraocular fluid // 2614103
FIELD: medicine.SUBSTANCE: invention refers to medicine and aims at surgical treatment of various types of glaucoma. Drain implanted in the intrascleral space is selected. For this purpose, tonography is performed. If the coefficient of ease of the intraocular fluid outflow is less than 0.1 mm/min/mmHg, synthetic suture material with thickness of 0.2-0.249 mm is used for drainage, if the coefficient of ease of the outflow ranges from 0.1 to 0.18 mm/min/mmHg, synthetic suture material with thickness of 0.15-0.199 mm is used, if the coefficient of ease of the outflow exceeds 0.18 mm/min/mmHg, synthetic suture material with thickness of 0.1-0.149 mm is used. At that, drainage is arc-shaped.EFFECT: invention allows prediction of postoperative outflow, creation of optimal conditions for the intraocular fluid outflow.3 ex
Drainage for intraocular fluid outflow // 2614102
FIELD: medicine.SUBSTANCE: invention refers to medicine and aims at surgical treatment of various types of glaucoma. The proposed drainage has an oval form, maid as a collapsible corrugated structure with a possibility of folding. Drainage is thickened in the central part and has a claw-like elements at the edges.EFFECT: invention provides not only the effect of intraocular pressure normalisation, but also the prolonged therapeutic effect on eye tissues.2 ex

ethod of surgical management of congenital hip dislocated in adolescence // 2614101
FIELD: medicine.SUBSTANCE: invention relates to traumatology and orthopaedics and can be used for surgical management of congenital hip dislocated in adolescence. Gigli saw is brought around femoral bone. Hip is transected by half its diameter. Osteotomy of external cortical thighs is made with vibration saw oblique downwards and from outside inwards to contact with previous line of corticotomy to make two fragments of hip with oblique fracture line in intertrochanteric and subtrochanteric areas. Behind lesser trochanter groove is made with grooved chisel, where proximal end of distal bone fragment is embedded. And proximal end of femur is shifted downward and forward as much as possible. Biomechanical axis of extremity is restored by bringing distal part of hip. Preset position of extremity is fixed on plate.EFFECT: method enables reducing length of staying in hospital, reducing risk of deformation in remote period.1 cl, 1 dwg
ethod for hand skin plastics // 2614100
FIELD: medicine.SUBSTANCE: general condition of the patient is pre-stabilized. An autograft is prepared. Necrotic tissues are removed, hemostasis and autoplasty are performed. At that, a fringing scalpel cut is made perpendicular to the skin surface at the border between the burn and the healthy skin in the interdigital spaces and on the side surfaces of the fingers. The skin is incised to the subcutaneous adipose tissue with formation of cuts in the form of angles and straight lines. Next, an electrodermatom is used on the hand dorsum, including the phalanges, to remove necrotic tissues down to the lower layers of the dermis, additionally in interdigital spaces and on the finger sides in the direction from the wound to the healthy skin and perpendicular to the bordering section, cuts are adhusted in the form of angles and straight lines to provide fit congruence of the solid free graft to the healthy skin.EFFECT: method ensures fit congruence of the solid free graft to the healthy skin, prevents development of postoperative scarring syndactyly and flexion contractures of fingers.8 dwg, 1 ex
ethod for neck of radius intramedullary osteosynthesis for children // 2614099
FIELD: medicine.SUBSTANCE: two needles are passed: one through the styloid process of the distal radius, the other - through the distal radius over the ulna notch to the proximal fragment of the neck of radius. The needles are introduced into the proximal fragment without entering the joint cavity. The needles are bent and cut in the distal section. The limb is fixed by a plaster cast.EFFECT: method allows to reduce trauma and increase the stability of fixation, prevent elbow joint contracture.1 dwg