RussianPatents.com
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Flu virus, capable of infecting canidae and its application. RU patent 2520081. |
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FIELD: medicine. SUBSTANCE: invention relates to the field of biotechnology and virology. Claimed are isolated strains of the flu virus, capable of infecting canidae and cause respiratory diseases in canidae. Compositions and methods for inducing immune response against the flu virus in canidae are also described. EFFECT: compositions and methods for identification of the invention virus and diagnostics of an animal infection with the flu virus are disclosed. 48 cl, 14 dwg, 57 tbl, 25 ex
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Antibacterial composition, strain of bacteriophage escherichia coli, used for obtaining thereof / 2518303 Invention relates to field of food industry, biotechnology and deals with antibacterial composition and strain of bacteriophage Escherichia coli, used for obtaining said composition. Characterised composition includes filtrate of Escherichia coli phage lysate, obtained with application of strain of bacteriophage Escherichia coli, deposited in collection of museum of microorganisms of Federal Budget Institution of Science "State Research Centre for Applied Microbiology and Biotechnology" of the Federal Service on Customers' Rights Protection and Human Well-being Surveillance (FBIS SRC AMB of Rospotrebnadzor) under number Ph 64, filtrate of Escherichia coli phage lysate, containing coli bacteriophage, filtrate of staphylococcus phage lysate, filtrate of salmonella phage lysate, filtrate of Listeria monocyctogenes phage lysate and target additives in amount 1.0÷95.0 wt % of composition weight. |
Strain of diploid cells of fetal lung of cattle for reproduction of viruses / 2515915 Strain of diploid cells of fetal lung of cattle is isolated from bovine fetal lung and is deposited in the Specialised Collection of passaged somatic cell cultures of farm and game animals of Russian Collection of vertebrate cell cultures (farm animals of Russian Academy of Agricultural Sciences) at the All-Russian Research Institute of Experimental Veterinary Medicine n.a. Ya.R.Kovalenko (ARIEV) under number 83. The strain is cultivated on medium Igla MEM and GLA of 1:1 with 10% fetal serum of cattle, free from viral, mycoplasmal and bacterial contamination. |
Associated inactivated emulsion bovine viral diarrhoea, rotavirus and coronavirus infections vaccine / 2515058 Invention refers to veterinary virology and biotechnology, and concerns a bovine viral diarrhoea, rotavirus and coronavirus infections vaccine. The described vaccine contains an active substance and a target additive. As the active substance, the vaccine contains a mixture of an avirulent purified antigen material of the strain NADL-VNIIZZh-DEP of bovine viral diarrhoea of the family Flaviviridae, of the genus Pestivirus, an avirulent purified antigen material of the strain 101 VNIIZZh-DEP of bovine rotavirus of the family Reoviridae, of the genus Rotavirus, and an avirulent purified antigen material of the strain VNIIZZh-DEP of bovine coronavirus of the family Coronaviridae, of the genus Coronaivirus deposited in the Russian National Collection of Microorganism Strains used in veterinary science and animal industry. The strains are taken in the relation of 1:1:1 in the amounts to provide the protective immune activity of each antigen in an animal's body after the target preparation is introduced. |
Subtype a type 1 iv742 human immunodeficiency viral strain for diagnostic and vaccine preparations / 2513693 Invention refers to a subtype A human immunodeficiency viral strain, and can be used in virology, medicine and biotechnology. The presented type 1 IV742 human immunodeficiency viral strain is deposited in the State Collection of Viruses of Federal State Institution Ivanovsky Research Institution of Virology of the Ministry of Healthcare and Social Development of the Russian Federation, No. 1187. The strain possesses a stable reproductive activity. An infectious titre makes 6 lg 50% tissue cytopathic dose. |
Subtype a type 1 iv710 human immunodeficiency viral strain resistant to antiretroviral preparations for diagnostic and vaccine preparations / 2513692 Invention refers to a subtype A human immunodeficiency viral strain, and can be used in virology, medicine and biotechnology. The presented type 1 IV710 human immunodeficiency viral strain is deposited in the State Collection of Viruses of Federal State Institution Ivanovsky Research Institution of Virology of the Ministry of Healthcare and Social Development of the Russian Federation, No. 1188. The strain possesses a stable reproductive activity. An infectious titre makes 3.5-4.0 lg 50% tissue cytopathic dose. |
Method of quantitative determination of fixed rabies virus "moskva 3253" / 2511440 Invention relates to field of biotechnology and deals with method of quantitative determination of fixed rabies virus strain "Moskva 3253". Method includes decontamination and separation of RNA from virus-containing material, carrying out reaction of reverse transcription and polymerase chain reaction with hybridization-fluorescence account of results in "real time" mode with application of specific primers RV5-5'-GTTGGGCACTGAAACTGCTA-3', RV6-5'-GAATCTCCGGGTTCAAGAGT-3' and probe RV7-5'-ROX-AATCCTCCTTGAACTCCATGCGACAGA-BHQ2. Quantitative assessment of virus is determined on the basis of registration of signal of analysed sample fluorescence and its comparison with signal of fluorescence of PCR-standards, which contain different quantities of DNA-targets. Claimed method makes it possible to determine quantitative content of virus in rabies antigen of organ-tissue and culture origin. |
Influenza virus strain a/hongkong/1/68/162/35 (h3n2) - universal donor of internal genes for reassortants, and reassortant strains a/spb/gk/09 (h1n1) and a/hk/astana/6:2/2010 (h5n1) prepared thereof / 2511431 Invention refers to medical biotechnology, and concerns influenza virus strains What is presented is the influenza virus strain A/Hongkong/1/68/162/35 (H3N2) deposited in the State Collection of Viruses of Ivanovskiy Scientific and Research Institution of Virology of Russian Academy of Medical Sciences, No.2442, that is a donor of internal genes for producing reassortant strains and prepared by passaging an agent through chicken embryos. The presented attenuation donor is used to produce the reassortant stains: A/SPb/GK/09 (H1N1) and A/HK/Astana/6:2/2010 (H5N1) deposited in the in the State Collection of Viruses of Ivanovskiy Scientific and Research Institution of Virology of Russian Academy of Medical Sciences, Nos. 2627 and 2626, respectively that inherit high reproductivity (9,5 lg) and an attenuation phenotype (ca) and thermal sensitivity (ts) respectively from the donor. |
Set of oligodeoxyribonucleotide primers and fluorescently labelled probe for identification of dna of adenoviruses of serotypes 3, 4, 7, 14, 21 by method of hybridisation-fluorescence polymerase chain reaction / 2511043 Invention relates to field of biotechnology and deals with set, which includes oligodeoxyribonucleotide primers and fluorescently labelled probe for identification of DNA of adenovirus of serotypes 3, 4, 7, 14, 21 by method of hybridization-fluorescence polymerase chain reaction in real time mode. Claimed primers and probe have the following structure: external primer 5'→3' 5'-AATGTARTTGGGTCTGTTRGGCAT-3' internal primers 5'→3' 5'-CCCWTCGATGMTGCCCC-3' 5'-TCMACGGGYACRAAGCGCA-3' probe 5'→3' ROX-CCTGTCCGGCGATGTGCAT-BHQ2. |
Strain of xh-18 virus of nuclear polyhedrosis of cotton budworm helicoverpa armigera hbn, used to obtain insecticide preparation / 2511042 Strain of virus of nuclear polyhedrosis of cotton budworm Helicoverpa armigera Hbn has high antiviral activity in relation to cotton budworm. It is deposited in the State collection of the Federal Service for Consumer Rights Protection and Human Welfare of causative pathogens of viral infections, rickettsial diseases of Federal Budget Institution of Science of State Science Centre of virology and biotechnology "Vector" under the registration number V-607, and can be used in the production of biological insecticides for agriculture. |
Method for preparing cattle parainfluenza-3 vaccine / 2509571 Invention relates to veterinary microbiology and concerns a method for preparing a cattle parainfluenza-3 vaccine. The presented method involves preparing a virus-containing material of a cattle parainfluenza-3 virus strain, infecting a continuous cell culture with the virus-containing material, culturing the cattle parainfluenza-3 virus, collecting a virus-containing fluid, inactivating it and preparing a liquid end product with the virus-containing fluid inactivated in an oxidant solution prepared by electrolysis of 10.0-20.0% sodium chloride to achieve pH values 7.0-8.0, the oxidant concentration of 0.7-0.9% and an oxidantion-reduction potential of +1000±50 mV and an inactivation agent consumption of 4.5-5.0 cm3 per 0.8-1.0 l of the virus-containing fluid with the virus-containing fluid inactivation being one-staged in the content of available chlorine Cax=250-500 mg/l for 60-70 min and at temperature 37-38°C at pH 7.2-7.4. |
Functional influenza virus-like particles (vlps) / 2483751 Group of inventions refers to medicine, namely biopharmaceutics, and may be used for making vaccines. For this purpose, the vaccine containing the influenza VLPs comprises the Ml, HA and NA proteins of the influenza virus wherein said vaccine induces a long-lived immunity to influenza virus infection in an individual susceptible to influenza, and wherein the MI protein of influenza is prepared of the influenza strain A/Indonesia/5/05. The group of inventions also refers to the use of the vaccine of the composition mention above for the induction of the long-lived immunity to influenza virus infection in an individual. |
Method to apply modified flu virus / 2480480 Methods are described to prevent a virus flu infection and detection of efficiency of a flu virus vaccine using a molecule of hemagglutinin (HA) of a flu virus A of subtype H5, immunogenicity of which is increased by replacement of amino acids in the HA sequence. |
New proteins h5, molecules of nucleic acids that code them and vectors, and their application in medicine / 2479589 Protein of flu virus hemagglutinin is disclosed, as well as a molecule of nucleic acid, which codes such protein, a vaccine for treatment or prevention of infections, which are mediated by a flu virus, a set and also methods to produce protein and vaccines. The protein of hemagglutinin H5 of the flu virus is characterised by the fact that in the position 223 of the series it is substituted with asparagine, and the second lysine is built into the position 328. |
Immunogenic compositions and methods / 2468034 Described are immunogenic peptides, compositions and methods of their application for therapeutic-prophylactic purposes and/or reduction of intensity against infectious disease, caused by influenza virus, containing two amino acid sequences, different from each other. Described is isolated polynucleotide, which codes immunogenic peptide. Invention includes isolated antibody, specific with respect to peptide. Composition by the invention based on immunogenic peptide is applied for obtaining medication or vaccine. Methods by the invention deals with induction of immunologic response against influenza virus, prevention or control of infection outbreak, cased by influenza virus, in population of mammals, and induction of protective immune response against influenza virus in mammals. |
Recombinant viral vector and expression system in plant cells of hybrid protein containing extracellular domain of protein m2 of influenza virus attached to core antigen of hepatitis b virus / 2460796 What is constructed is a synthetic gene optimised for expression in plant cells, coding a hybrid protein M2epHBc including an extracellular domain of protein M2 of influenza virus attached to a core antigen of hepatitis B virus. Said protein is produced in plants by constructing a recombinant viral vector on the basis of a genome of potato X-virus. A fragment of the genome of potato X-virus comprising a gene sequence coding M2epHBc has been cloned under the control of a promoter active in plant cells; the whole construct is cloned within a t-DNA region of binary agrobacterial vector. |
Recombinant swine influenza virus h1n1 vaccine and method for preparing it / 2451027 Engineered recombinant protein molecule for preparing a recombinant vaccine for an infection caused by swine influenza virus (HlNlv-2009). The molecule consists of a residue of methionine, a sequence of extracellular M2 protein domain of 2 to 24 amino acids and a sequence of a nuclear hepatitis B virus antigen of 4 to 149 amino acids. The molecule is able to form virus-like particles. There are also disclosed a recombinant nucleic acid coding such molecule, a vector for its expression, virus-like particles formed by such molecules and a vaccine based on the prepared virus-like particles. |
Canine influenza virus a strain (versions), immunogenic polypeptide, polynucleotide coding same, polypeptide expression vector, immunogenic composition containing polypeptide and method for inducing animal immune response / 2449014 Invention relates to biotechnology and virology. Compositions and methods used to induce immune response against the influenza virus in canines using novel strains, polynucleotides or polypeptides thereof are described. The invention can be used in veterinary. |
Modified influenza virus for monitoring and increasing vaccine efficacy / 2420535 It is described that immunogenicity of hemagglutinin (HA) molecule of influenza virus can be increased by substituting amino acids in the HA sequence. Substituting specific residues in HA such as asparagine introduction in position 223 in HA H5 allows ensuring more sensitive hemagglutination inhibition (HI) test provided by changing receptor specificity and/or ability to antibody-antigen linkage. The HA molecules having such substitutions can find application in creating diagnostic prototype viruses. |
Canine influenza virus, compositions containing said virus and application thereof / 2410427 Present invention relates to biotechnology and specifically to isolated canine influenza virus subtype H3N8 which contains HA protein. Described also is a composition which contains an attenuated or inactivated virus and isolated or purified proteins HA, NM, NP, M1, NS1, PA, PB1 and pB2 and fragments thereof. |
Effective influenza vlps / 2369405 Immunogenic vaccine composition comprises macromolecular protein structure containing proteins of bird influenza virus HA, NA, and Ml and a carrier or dilution agent. The suggested group of inventions provides safety recombinant vaccine practice and highly immunogenic self-organised macromolecules integrated in plasmamembranes comprising multivariate replicas of structural protein of bird influenza virus demonstrating neutralising epitopes in native conformations. |
Influenza virus strain a/hongkong/1/68/162/35 (h3n2) - universal donor of internal genes for reassortants, and reassortant strains a/spb/gk/09 (h1n1) and a/hk/astana/6:2/2010 (h5n1) prepared thereof / 2511431 Invention refers to medical biotechnology, and concerns influenza virus strains What is presented is the influenza virus strain A/Hongkong/1/68/162/35 (H3N2) deposited in the State Collection of Viruses of Ivanovskiy Scientific and Research Institution of Virology of Russian Academy of Medical Sciences, No.2442, that is a donor of internal genes for producing reassortant strains and prepared by passaging an agent through chicken embryos. The presented attenuation donor is used to produce the reassortant stains: A/SPb/GK/09 (H1N1) and A/HK/Astana/6:2/2010 (H5N1) deposited in the in the State Collection of Viruses of Ivanovskiy Scientific and Research Institution of Virology of Russian Academy of Medical Sciences, Nos. 2627 and 2626, respectively that inherit high reproductivity (9,5 lg) and an attenuation phenotype (ca) and thermal sensitivity (ts) respectively from the donor. |
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