Method of treating patients with tobacco addiction |
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IPC classes for russian patent Method of treating patients with tobacco addiction (RU 2506969):
Tabletted chewing gums / 2501551
Invention refers to medicine. There are described specific types of nicotin-containing chewing gums providing high transbuccal absorption rate, high plasma concentrations for the first 10 minutes after use in an individual chosen to give up smoking.
 Compositions and methods of preventing and treating addictions / 2492858
There are presented methods of treating or preventing an addiction or recurrent addictive behaviour, including: alcohol, nicotine, marijuana, marijuana derivative, opioid receptor antagonist, benzodiazepine, barbiturate and psychostimulant by administering the peroxisome proliferator-activated receptor gamma (PPARγ) agonist thiazolidinedione, alone or in a combination with another therapeutic agent - an opioid receptor agonist, a mixed partial opioid receptor agonist/antagonist, an anti-depressant, an antiepileptic agent, an antiemetic agent, a corticotrophin releasing factor 1 (CRF-1) receptor antagonist, a selective serotonin 5-HT3 receptor antagonist, a 5-HT2A/2C antagonist or a cannabinoid 1 (CB1) receptor antagonist (versions), related pharmaceutical compositions with the above combinations (versions), a standard dosage form (versions) and kits (versions).
Multicomponent oral dosage form with organoleptic properties / 2490010
Present invention refers to medicine, namely consisting of many portions of an oral dosage form containing at least two portions; each of the above two portions comprises at least one pharmaceutically active agent or an agent specified from a teeth whitening agent, an oral health agent, an oral anti-caries agent, a saliva-enhancing agent and/or herbal extracts wherein at least one of the above two portions comprises a pharmaceutically active agent selected from a group consisting of nicotine compounds, wherein the above at least two portions comprise a different flavour to notice the user that the above on the pharmaceutically active agent or the agents selected from the teeth whitening agent, the breath agent, the oral health agent, the anti-caries agent, the saliva-enhancing agent, and herbal extract, got to release from the above portion; and the above dosage form is other than a chewing gum.
 Nicotinic ummunonanotherapeutic drugs / 2487712
What is presented is a composition for nicotinic immunonanotherapy containing synthetic nanocarriers having a polymeric surface conjugated with a variety of nicotine residues with the variety of the nicotinic residues on the nanocarrier form an immunogenic surface providing a low affinity, a high-avidity binding of the nicotinic residues to the surfaces of an antigen presenting cell (APC) compared with an antibody binding, and a pharmaceutically acceptable excipient. The invention provides the nanocarriers capable to stimulate an immune response in T-cells and/or B cells and to produce the antinicotin antibodies with the humoral and cellular response to be achieved in the absence of an exogenous adjuvant.
 Bupropion hydrobromide and therapeutic applications thereof / 2485943
Invention refers to bupropion hydrobromide and formulations thereof, and applications thereof. The pharmaceutical composition contains an effective amount of bupropion hydrobromide, and at least one pharmaceutically acceptable adjuvant. The composition is applicable as a drug for preventing and/or decreasing a rate of convulsions and/or attacks associated with the administration of bupropion, in treating major depressive disorder, bipolar affective disorder, other affective disorders, anxiety disorder, general neurotic syndrome, panic disorder, posttraumatic stress disorder, nicotine addiction, obesity, attention deficit/hyperactivity disorder, restless legs syndrome (Ekbom syndrome), sexual dysfunctions and seasonal mood disorders.
 Bupropion hydrobromide and therapeutic applications thereof / 2485942
Modified release pharmaceutical composition of bupropion hydrobromide contains a core with a therapeutically effective amount of bupropion hydrobromide and a controlled release polymeric coating. The coating contains a water-insoluble polymer in an amount of 1 wt % to 12 wt % of tablet weight and a water-soluble polymer in an amount of 1.5 wt % to 10 wt % of weight tablet. The above coating surrounds the core at least partially. The composition releases bupropion hydrobromide in a dissolution medium containing 0.1N HCl and 5%-40 vol % of ethanol at a rate of approximately 1.1 or less than a release rate of bupropion hydrobromide from a modified-release similar pharmaceutical composition in a dissolution medium containing 0,1N HCl, measured over the range of time at least from 0 to 2 hours by means of type I USP apparatus at 75 rpm and at 37 ±5°C.
 Controlled release solid drug / 2467740
Invention refers to medicine and pharmaceutical industry, and concerns a controlled release drug exceeding an active ingredient in stability. The drug may show pharmacological effects stably and immediately after the introduction, and provides a prolonged pharmacological effect for a long period of time.
 Selective antagonists of adenosine a2a receptors / 2467009
Compound, selected from compound given in Table 1 or in Table A correspond to general formulae:
Liquid composition for nicotine delivery / 2457822
Invention relates to pharmaceutical industry and represents liquid composition for treatment of tobacco or nicotine addiction or for weight control after giving up smoking, characterised by the fact that it represents medicinal body lotion, which contains nicotine in any form in amount 0.5-15 mg, calculated relative to form of free base of nicotine per strandardised dose, and solvent, where composition is intended for transdermal delivery of nicotine to patient and does not contain tobacco, composition does not contain any uncrosslinked water-insoluble vinylpyrrolidone copolymer, copolymerised with hydrophobic comonomer.
 Azaadamantane derivatives and methods for applying / 2450002
Invention refers to azaadamantane derivatives of formula (I), to their pharmaceutically acceptable salts possessing the properties of nAChR ligands, their application, a method of treating and based pharmaceutical compositions, and also to intermediate compounds of formula (VI) and (VII) and to application of the compound of formula (V) for preparing the compound (I). In general formulas
Method of treating ulcerative colitis / 2506100
Invention refers to medicine, namely to gastroenterology, physiotherapy. A method involves a drug therapy. A physical therapy is added. For this purpose, roots of lungs are exposed to interferential currents of carrier frequency 5000-6000 Hz and modulation frequency 100-200 Hz of the length of 12-15 seconds. The electrodes are placed within a projection of root of lungs and attached to a skin surface with local depression 0.1-0.2 atm.
Method of treating patients suffering primary open-angle glaucoma / 2506062
Invention refers to medicine, namely ophthalmology, physiotherapy. The method involves endonasal cortexin electrophoresis with underlying glaucoma therapy. Cortexin is administered from an anode. For this purpose, a bifurcated positive electrode is applied on cotton swabs wetted in a drug solution. The electrodes are introduced into the middle nasal passages. An indifferent electrode is fixed with elastic bandages on the skin of the posterior surface of the neck. The first two procedures require galvanisation at current intensity 0.5 mA for 7 minutes. That is followed by medical cortexin electrophoresis from 3rd to 12th sessions. The current intensity from the 3rd to 5th sessions is 1 mA for 10 minutes. The current intensity from the 6th to 12th sessions is 1 mA for 15 minutes. The procedures are performed every second day.
Method of treating sciatic neuropathy following hip replacement or acetabular facture / 2504412
Invention refers to medicine, namely traumatology and neurosurgery. Transient electrodes are implanted under neurophysiological control and by means of an image converter: the first electrode is epidural and implanted in a projection of the segment L3-4 or L4-5 or L5-S1. Soft tissue hydropreparation in a projection of a sciatic nerve is followed by implanting the second epineural electrode under a gluteal fold. If observing the voluntary activity in an innervation zone of a peroneal nerve, a third electrode is placed and fixed in an upper one-third of the shin in a projection of the peroneal nerve. The postoperative electric stimulation is performed 2 times a day for 14 days.
Method of treating patients with hypomotor dysfunction of gallbladder / 2504411
Invention refers to medicine, namely physiotherapy. A method involves the administration of chophytol, diet therapy, magnetic therapy and exposure to electric current. The magnetic therapy is performed by a low-frequency sinusoidal alternating magnetic field. The exposure covers a collar zone and liver for 10-15 minutes. A continuous mode, frequency 50 Hz, grade I-II magentic induction are specified. The magnetic therapy is immediately followed by the exposure to complex-modulated pulse electric current with a neural-like pulse shape. The exposure is generated at the level ThVII - ThXI, paravertebrally to the right, and cover skin projections within the liver and gallbladder transversally. For this purpose, the electrodes are placed in 6 procedure fields: 1 - paravertebrally to the right at the level of the ThVII spine, 2 - paravertebrally to the right at the level of the ThXI spine, 3 - in a projection of the liver on a front surface of the body, 4 - in a projection of the liver on a back surface of the body, 5 - in a projection of the gallbladder on the front surface of the body, 6 - in a projection of the gallbladder on the back surface of the body. The 1st and 2nd electrodes are connected to the channel IV, while the 3rd and 4th electrodes - to the channel I, and the 5th and 6th electrodes are connected to the channel II. The channels I, II work in a frequency-drift group mode. The channel IV work in a continuous mode at fixed frequency 20 Hz. The current intensity is adjusted to apparent vibration sensation. Duration of a session is 10-15 minutes. The therapeutic course is 10-12 daily procedures.
Method for rehabilitation of patients suffering deforming arthrosis of knee joints / 2502500
Invention refers to medicine, namely to - arthrology, physiotherapy, balneology. The method involves physical methods of therapy, therapeutic exercises, massage, acupuncture and phytotherapy. The patients are trained to give a self-massage of the knee joints additionally during the resort therapy and after the termination of the rehabilitation. From the 1st to 10th day of the therapeutic course patient's knee joint is exposed to polychromatic polarised light at 20 cm for 6 minutes. The patients take 10 iodine-bromine baths at temperature 37°C for 10 minutes. From the 1st to 5th therapeutic days, the patients do combined therapeutic exercises; their lower extremities are massaged manually for 10 minutes. From the 6th to 15th days, the knee joints are exposed to sinusoid modulated currents (SMC) at modulation frequency 100 Hz, at a depth of 50 - 70%, current intensity to moderate vibration for 7 minutes. From the 6th to 10th days, the braking acupuncture follows by giving a 1-2-minute massage of the points 10RP, 9RP, 36E, 34E by introducing a needle for 30 seconds and by giving a point massage of cheng-fu, cuan, yang-lin-cuan, zu-sang-li, wei-yang, cheng-shan, chung-feng, hun-lun, nei-ting. The patients take a herbal infusion. From the 11th to 15th days, the knee joints are exposed to decimetric waves (DMW). That is followed by a hydro-massage of the lower extremities and lumbar region for 15 minutes up to 3 atm. Thereafter, the 10-minute post-isometric relaxation of the quadriceps muscle of thigh is applied. The patients do the complex of weight reduction exercises and take the herbal infusion. From the 16th to 20th day, the mud applications on the knee joints are prescribed at temperature 42°C for 30 minutes. If suffering gonarthrosis, the patients do the complex of therapeutic exercises. That is followed by the paravertebral vacuum therapy of the vertebral column. The 10-minute knee joint traction is applied. The patients take 20 g of the herbal infusion.
Method of treating patients with neurologic impairment accompanying peripheral neuropathies or plexopathies / 2499615
Invention refers to medicine, namely neurology, physiotherapy. The solution of proserine is introduced 30 minutes before conducting low intensity electrical stimulation. Amplitude of the electrical stimulation is 10-20 mA, frequency is 40-40 Hz, and length is 900 seconds.
Method for electromagnetic stimulation of central and peripheral nerve system / 2499614
Invention refers to medicine, namely to neurosurgery and rehabilitation medicine. A principal stage of the surgical intervention is followed by placing at least one electrode for neuromodulation in an abnormal focus. In the postoperative period, the Kronlein - Brusova scheme is used to localise a projection of anterior central gyri on the head skin, and the transcranial Doppler sonography follows. The presence and location of the temporal and suboccipical window are stated. It is the temporal window the closest to a projection of the anterior central gyri that is selected. Local magnetic emitters are placed in projections of the selected temporal and suboccipital windows. That is combined with the local exposure to the magnetic field by means of the placed emitters and electric current through the electrodes for neurostimulation. The 10-15-minute stimulation is performed three times a day for 15-20 days.
Method for training pelvic floor muscles in treating patients suffering erectile dysfunction following radical prostatectomy / 2499585
Invention refers to medicine, specifically urology. A method involves the complex postoperative rehabilitation. From the 10th postoperative day, the patient is exposed to electric myostimulation at current intensity to pelvic floor muscle contraction, frequency 30-50 Hz, modulation depth 100% for 10-15 minutes. The therapeutic course is 12-20 daily procedures. In one month from the operation, the ischiocavernous and bulbospongiosus muscles are trained. That involves doing three exercises thinking of 'penis contraction'. The first exercise represents 5 tensions with maximum intensity (100%), length 5 seconds and tension pauses 90 seconds. The second exercise represents 5 tensions with intensity 50% of maximum intensity, length 15 seconds and tension pauses 20 seconds. The second exercise represents 5 tensions with intensity 30% of maximum intensity, length 30 seconds and tension pauses 20 seconds. The exercises are done min. 3 times, once a week in the morning and evening. They are added with doing the interval exercises for lower extremity muscles. The exercises include 15-minute warm-up activities and doing the exercises of intensity 70-80% of maximum intensity, 50-60% of maximum heart rate, repeated for 5 times with 3-minute pauses. The exercises are done not less than 3 times. From the second postoperative month, a phosphodiesterase-5 inhibitor is administered.
Method for prevention of forearm rotational contracture in colles fractures / 2496531
Invention refers to medicine, namely - to traumatology, physiotherapy. The method involves electric stimulation of superficial muscles involved in forearm rotative motions. The electric stimulation is started from the third day of immobilisation. The exposure is conducted in the subthreshold mode, at current frequency 2 Hz, length 500 msec, pulse current 10 to 60 mA. The procedures are performed twice a day for 10-15 days. From the 10th day of immobilisation, the muscles are electrically stimulated in the subthreshold mode. The exposure is conducted at current frequency 50-100 Hz, half-cycle length 2-3 s, twice a day for 10-15 minutes.
Method of treating endometriosis / 2493808
Invention relates to medicine, namely to gynecology, physiotherapy. Transcreanial electrostimulation is carried out, performing impact in accordance with fronto-occipital method with pulse monopolar current to 2 mA. First electrostimulation procedure is performed with current intensity until sensation of vibration in the range 0.5-1.0 mA, in each following procedure current intensity is increased from 0.2 to 0.4 mA, but not more than 2.0 mA. Duration of first and second procedures constitutes 15-20 minutes, duration of the following procedures being 30 minutes. Transcranial electrostimulation is performed every second day, alternating it with iodine-bromine balneotherapy. Balneotherapy is performed in form of vaginal irrigations and general baths with application of iodine-bromine water with temperature 36-37 degrees, with 10-15 minute duration. Course consists of 8 balneo- and physio-procedures.
 Derivatives of oxazolidine antibiotics / 2506263
Invention relates to compound of formula I
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FIELD: medicine. SUBSTANCE: invention refers to medicine, namely to addictology, and concerns treating the patients with tobacco addiction. That is ensured by the 12-day therapeutic course. For this purpose, Teraligen is administered in a daily dose of 15-20 mg. What is also involved is mesodiencephalic modulation with low frequency currents 60-90 Hz, duration 3-5 ms, amplitude 1-5 mV for 35-45 minutes when the electrodes are placed in an occipitofrontal region. That is also combined with inhalations of atrovent in a dose of 0.7-1.5 ml in normal saline 3 ml and lasolvan in a dose of 0.8-1.2 ml in normal saline 3 ml on the first day. The same doses of the above preparations are inhaled in a combination in normal saline 2 ml on the following days. The treatment is added with a vacuum massage in a pulse mode of amplitude 100-500 mbar and frequency 0.8-2.5 Hz. EFFECT: method prevents or reduces the intensity of psycho-vegetative disorders and recovers the ventilation function in the patients in the smoking cessation state that ultimately increases the number of patients stopping smoking completely. 3 ex
The invention relates to the field of medicine, namely to addiction) and can be used as a method of treatment of tobacco dependence at the stage of Smoking cessation. There is a method of treatment of tobacco dependence using acupuncture (1 - Smirnov V.K. Clinic and treatment of tobacco dependence. - M., 2000, p.95.). This method is adopted for the similar. There is a method of treatment of tobacco dependence by the integrated application of MDM therapy (physiotherapy method mesodiencephalic modulation) and Grandaxin (anxiolytic. atypical derived benzodiazepine) (2 - RF Patent 2234954. 2002). This method is adopted for the prototype. However, the effectiveness of the method is limited, as agitation, aggression or depression, developing a number of patients in the early days of Smoking cessation, are contraindications to assign Grandaxin (3 - Register of medicines of Russia radar encyclopedia of medicine. - 19-th vol. / CH. edit GL the vishkovsky. - M.: "radar-MEDIA". 2010 - 1368 S. S). The aim of the invention is to increase the efficiency of treatment of patients with tobacco dependence by preventing or reducing the intensity of psychovegetative disorders that may cause a return to Smoking. The technical result is achieved by the fact. they spend 12-day course of Terrigena in the days the first dose of 15-20 mg in combination with mesodiencephalic modulation currents of low frequency 60-90 Hz. duration 3-5 mampituba 1-5 mV for 35-45 minutes at fronto-occipital location of the electrodes, by inhalation atrovent dose of 0.7-1.5 ml in 3 ml of isotonic sodium chloride and Lasolvan 0.8-1.2 ml in 3 ml of isotonic sodium chloride on the first day and in the same doses together in 2 ml of sodium chloride in the next days and vacuum massage in pulsed mode amplitude 100-500 mbar and a frequency of 0.8-2.5 Hz. The essence of the proposed method is as follows: - appointment of Terrigena (readings: neurosis-like state, psychovegetative and psihasteniceskie disorders, sleep disorders. developing in patients with tobacco dependence, starting with 2-3 days after Smoking cessation) the choice of this drug from the group of neuroleptics when Smoking cessation is based on the existence of inflammatory and antiemetic effects, which prevent the possibility of complaints from the gastrointestinal tract in the stress of quitting Smoking; the combination of MDM therapy due to the generation of endorphins can reduce the dose of Terrigena with 60-80 mg recommended to achieve a good effect, up to 15-20 mg per day; the effect of inhalation and vacuum massage with one hand, and the antitussive effect of Terrigena. on the other, are synergistic regarding recovery of respiratory function. broken with long-term tobacco Smoking. Restore this feature greatly contributes to the improvement of the General condition of patients. The method is implemented as follows. The patient was admitted with a long status smoker and regularly dependent Smoking 1-2 packs a day. The decision to giving up Smoking took in connection with the deterioration of health. Conducted counseling with the goal of enhancing motivation. In the future, was held re psychotherapeutic conversation, because Smoking cessation was accompanied by deterioration in emotional state (appearance irritability, temper, periodically - a state of melancholy)that questioned the possibility of quitting. In addition, increased cough with difficult detachable sputum, which in recent years has concerned only in the morning. Carry out reception of Terrigena in a daily dose of 15-20 mg (5 mg 3-4 times a day) and physiotherapy. Spend mesodiencephalic modulation currents of low frequency 60-90 kg, duration of 3-5 MS. the amplitude of 1-5 mV for 35-45 minutes at fronto-occipital location of the electrodes. Produce inhalation: first day atrovent and Lasolvan separately (including possible allergic reactions). atrovent dose of 0.7-1.5 ml 3 ml of physiological solution, Lasolvan at a dose of 0.8-1.2 ml 3 ml of physiological rest the RA: in the next days together in the same doses with the addition of 2.0 ml of physiological solution. Perform vacuum back massage in a pulsed mode amplitude 100-500 mbar and a frequency of 0.8-2.5 Hz Procedures carried out during the day with the interval between treatments 2-2 .5 hours. By the end of the treatment course the patient's health has improved. The patient does not smoked, preserved the mood for a full cessation of Smoking in the future. It was recommended the continuation of reception of terrigena within 2 weeks, if needed psychotherapy. The method is further confirmed by the examples. Example 1. Patient K., 42 years old, was admitted with a diagnosis of Chronic biliary pancreatitis, often relapsing course, aggravation. Cholelithiasis: cholecystolithiasis. Peptic ulcer disease duodenal ulcer in remission. Status smoker was assessed as "regular dependent smoke: smoked from the age of 17, in recent years, 20-30 cigarettes a day. Previously attempted to quit Smoking, however due to the sharp deterioration in 2-3 days returned to Smoking. The decision to giving up Smoking took due to ill health. Smoking cessation was accompanied by deterioration in emotional state (appearance irritability, temper, interspersed with depression)that questioned the possibility of quitting. In addition, increased cough with difficult detachable sputum, which in the last years were disturbed only in the morning. Treatment (course 12 days): - Terlingen at a dose of 15 mg 3 times a day side effects was not. - Physiotherapy: MDM-therapy apparatus MDM 101" currents of low frequency (60 Hz. the pulse duration of 3 MS, pulse amplitude 1 mV) at fronto-occipital electrode positioning, procedure duration of 35 minutes; inhalation: first day atrovent dose of 0.7 ml in 3 ml of isotonic sodium chloride, Lasolvan at a dose of 0.8 ml in 3 ml of isotonic sodium chloride solution in the next days - atrovent dose of 0.7 ml and Lasolvan at a dose of 0.8 ml together in 2 ml of isotonic sodium chloride: vacuum back massage in a pulsed mode with an amplitude of 100 mbar frequency of 0.8 Hz. The interval between treatments 2 hours. Completely stopped Smoking, phone survey after a year of Smoking has not returned. Example 2. Sick So 37 years. he admitted with a diagnosis of gastric Ulcer and duodenal ulcer, relapsing course, aggravation. Status smoker -"regular dependent Smoking." Smokes 15 years, in recent years 10-15 cigarettes a day. The decision to quit Smoking has taken on the advice of a physician due to the frequent recurrence of peptic ulcer disease. Smoking cessation was accompanied by deterioration in emotional state in the form of irritability, sleep disturbance with the advent of disturbing dreams. havelse cough with mucus secretion, which had sporadically. Treatment (course 12 days): - Terlingen at a dose of 5 mg 4 times a day (20 mg). side effects were not. - Physiotherapy: MDM - therapy apparatus MDM 101" currents of low frequency (90 Hz. pulse duration of 5 MS. the pulse amplitude of 5 mV for 45 min) at fronto-occipital electrode positioning; inhalation: first day atrovent dose of 1.5 ml in 3 ml of isotonic sodium chloride, Lasolvan at a dose of 1.2 ml in 3 ml of isotonic solution of sodium chloride, in the days that followed atrovent and Lasolvan in the same doses with the addition of 2 ml of isotonic sodium chloride solution; vacuum back massage in a pulsed mode with an amplitude of 500 mbar frequency of 2.5 Hz. 12 procedures. The interval between treatments 2.5 hours. The result is cessation. The complete disappearance of psychovegetative disorders resulting from Smoking cessation, normalization of sleep. Complete healing of the ulcers as a result of the treatment. After a year of not Smoking (telephone interviewing). Example 3. Patient I., aged 22, was admitted with a diagnosis of Chronic gastro duodenitis, acute exacerbation. Status smoker: "regular dependent smoke: smoke from the age of 12, in recent years 25-40 cigarettes a day. Offer assistance in quitting Smoking took after talking to a psychologist due to ill health, as well as the negative experience of the area nearest relative (intermittent claudication on the background of the disease). Smoking cessation was accompanied by the emergence of aggressive behavior. Treatment (course 12 days): - Terlingen dose] 7.5 mg per day. - MDM-therapy apparatus MDM 101" currents of low frequency (80 Hz, pulse duration of 4 MS, the pulse amplitude of 3 mV). the duration of the treatment - 40 minutes; inhalation: first day atrovent dose of 1.0 ml in 3 ml of isotonic sodium chloride, Lasolvan at a dose of 1.0 ml in 3 ml of isotonic sodium chloride solution in the next days - atrovent dose of 1.0 ml, Lasolvan at a dose of 1.0 ml with the addition of 2 ml of isotonic sodium chloride solution; vacuum back massage in a pulsed mode with an amplitude of 300 mbar frequency of 1.5 Hz. The interval between treatments 2 hours. Result: the treatment endured with difficulty (deterioration of physical health due to Smoking cessation was accompanied by obsessive thoughts about returning to Smoking - was conducted psychotherapy), the condition improved after 10 treatments. At discharge from the hospital did not smoke. Method of treatment of tobacco dependence, characterized in that conduct a 12-day course of terrigena in a daily dose of 15-20 mg in combination with mesodiencephalic modulation currents of low frequency 60-90 Hz, with a duration of 3-5 MS, the amplitude of 1-5 mV for 35-45 minutes at fronto-occipital location of the electrodes, by inhalation atrovent dose of 0.7 to 1.5 is l in 3 ml of isotonic sodium chloride and Lasolvan at a dose of 0.8-1.2 ml in 3 ml of isotonic sodium chloride on the first day and in the same doses together in 2 ml of isotonic solution of sodium chloride in subsequent days and vacuum massage in pulsed mode amplitude 100-500 mbar and a frequency of 0.8-2.5 Hz.
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