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Agent for external therapy of chronic recurrent inflammatory dermatopathies
IPC classes for russian patent Agent for external therapy of chronic recurrent inflammatory dermatopathies (RU 2475249):
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FIELD: medicine.

SUBSTANCE: what is presented is the use of xenon in the form of an agent for external therapy of chronic recurrent inflammatory dermatopathies prepared by extra pure grade xenon saturation of a fatty base.

EFFECT: what is shown is considerable reduction of an inflammatory reaction on the second therapeutic day in such polygenic chronic inflammatory diseases, as psoriasis, atopic dermatitis, acne, acne rosacea, eczema.

4 ex

 

The invention relates to medicine and can be used in dermatology for the external treatment of chronic inflammatory skin diseases such as psoriasis, atopic dermatitis, acne, rosacea, eczema.

Psoriasis is one of the most common skin diseases. According to the statistics of this disease suffers from 1 to 8% of the world population. The frequent cases of severe forms that are difficult to treat and lead to disability in patients with frequent and prolonged recurrence (1).

Atopic dermatitis (AD) is one of the most common diseases encountered in all countries, in both sexes and in different age groups. According to numerous authors, the incidence varies from 6% to 20% per 1,000 population. The incidence of AD among residents of cities is higher than that of rural residents. In children blood pressure can occur in 1-4% of cases (10-15%) among the entire population, cohda as adults (0,2-0,5% of cases (2).

Acne (acne) is the most common chronic relapsing disease of the sebaceous glands and hair follicles that affects up to 85% of persons aged 12 to 25 years of age and 11% of persons over the age of 25 years (3).

Eczema is commonly found in relapsing disease of the skin, occurring at any age. Eczema is 30-40% of all skin related disease is evani (4).

Rosacea is a chronic, relapsing disease, usually of the skin, with polietiologic nature. Among dermatological diagnoses it is about 5% (5).

The Arsenal of tools used for the external treatment of chronic recurrent inflammatory skin diseases include common ointments, as sulphur ointment, papaverine cream, cream Uns, zinc ointment, etc.

Despite the achievements of domestic and foreign dermatology, the incidence of dermatitis remains very high. Currently, there is an increasing number of patients are resistant to traditional external therapy, and many dosage forms may not be used because of drug intolerance and formation of side-effects (6).

Object of the invention is the expansion of the means of the external treatment of skin diseases, the reduction of treatment time.

This object is achieved in that as a means of external therapy of chronic recurrent inflammatory diseases of the skin using xenon.

Previously known use of xenon as an inhalation anaesthetic with analgesic, antispasmodic, cardiotonic, neuroprotective, anti-stress, antihypoxic, immunostimulating, protivovospalitel the elegance, anabolic, neurohumoral, vasoplegic properties (7).

According to the Ministry of health of the Russian Federation No. 363 of 10.10.1999, Pharmacological Committee of Russia allowed the use of xenon in medical practice.

In the analysed literature, the use of xenon in clinical practice as a means for the external treatment of chronic recurrent inflammatory skin disease is not detected. Thus, in the claimed invention xenon exerts its new property, which leads to the achievement of a new technical result, and the proposed remedy is not adequate analogues, explicitly does not follow from the prior art and is not obvious to the expert.

The present invention can be used in medical practice as a new tool for the treatment of chronic recurrent inflammatory skin diseases, reduces the time of treatment of skin diseases.

Based on the foregoing should be considered as the invention with the relevant conditions of patentability of "Novelty", "Inventive step", "Industrial applicability".

The invention will be clear from the following description.

The proposed remedy for the external treatment is obtained by saturation of fatty basis xenon high purity (Xenon PTS", THE 2114-003-39791733-2002) methodology is ozonation. Bubbling routed through the bubblers of the porous glass flasks 1000 ml, in a volume of inert gas xenon, equal to the volume of a fatty basis to achieve equilibrium concentration. The ozonation process is carried out at a temperature of 35-40°C for 5-10 minutes with continuous stirring. Determination of the gas content in the medium for the external treatment is carried out using the method of gas-liquid chromatography.

The treatment is carried out by assigning to the affected skin areas of xenon in the form of outdoor therapy in the dose required for applying a thin layer of adequate lesion 1-2 times a day, morning and evening, for the treatment of various chronic recurrent inflammatory skin diseases (psoriasis, acne, atopic dermatitis, rosacea, eczema).

Example 1. Patient M., 56 years. Ds: Psoriasis vulgaris, numularia-plaque, spread, mixed, progressive stage, PASI=28, 2 points.

Topical treatment is applied on the left half of the body cream Uns. On the right half of the body cause the tool of external therapy in the form of a cream, enriched xenon. The base of the cream get the following formula:

Rp: Lanolini

Ol. Persicorum

Aq. destil. aa 50,0

M.D.S. cream Foundation for ozonation xenon.

Outdoor therapy is applied in equal amounts to poraj the nnye areas 2 times a day, morning and evening, together with the use of primary care.

The patient is thermometry pathological lesions, and assessment of the clinical picture index square of psoriatic lesions and the severity of the process PASI.

- 2 day outdoor therapy: right PASI=21.4 points, left PASI=26.2 points, indicators thermometry decreased to a greater extent on the right 0.53°C, left by 0.31°C.

- Day 7: the right PASI=9.2 points, left PASI=18.6 points. Because the severity of the clinical picture index PASI left decreased by 34%, and the right to 67,4%, which is 1.98 times more, as well as indicators of temperature, showing a significant reduction of the inflammatory reaction to the right, decided as a local therapy to apply the tool, enriched xenon.

Indicators of temperature (Δt°C)*
day Right 1/2 Left 1/2
1 35,72 35,59
2 35,19 35,28
7 32,96 34,94
16 30,93 31,05

* - thermometry is performed on the largest psoriatic plaques legs. Measurements performed in 11 points pathological lesions using the apparatus of THIS Thermo Diagnostics and further calculating Δt°C.

- When discharged on the 16th day PASI is 3.6 points and, thus, PASI decreased by 87.2%of that meets the criteria for significant improvements.

Example 2. Patient S., 28 years. Ds: Atopic dermatitis, erythematous-lihenina form. Assessment using SCORAD index was 49. Sick since 3 years, notes the deterioration in the spring and autumn period.

Topical treatment is applied on the left half of the body papaverine cream 5%. On the right half of the body cause the tool of external therapy in the form of a cream, enriched xenon. The base of the cream get the following formula:

Rp: Lanolini

Ol. Persicorum

Aq. destil. aa 50,0

M.D.S. cream Foundation for ozonation xenon.

Outdoor treatment is applied in an equal amount to the affected areas 2 times a day, morning and evening, together with the use of primary care.

The patient is thermometry pathological lesions, and assessment of the clinical picture index evaluation of the cords is STI atopic dermatitis SCORAD.

- On the 2nd day of treatment: right SCORAD=40.5 points, left SCORAD=46 points; indicators thermometry decreased to a greater extent right on 0,69°C, left at 0,21°C.

- On the 7th day of treatment: right SCORAD=27.1 points, left SCORAD=36.7 points. Due to the fact that the evaluation index SCORAD left fell 25.1%, and the right 44.7%that of 1.78 times more, and indicators of temperature, indicating a decrease in inflammatory activity right at 2°C and left by 0.65°C, an increase of 1.35°C, it was decided as a local therapy to apply the tool, enriched xenon.

Indicators of temperature (Δt°)*
day Right 1/2 Left 1/2
1 35,69 35,7
2 35 35,49
7 33,69 35,05
18 32,22 32,42
* - thermometry is performed on pathological foci flexor surface of the elbow joints. The measurement issue is lnewt 11 points pathological lesions using the apparatus of THIS Thermo Diagnostics and further calculating Δt°C.

At discharge on the 18th day evaluation of the clinical picture using SCORAD index is 8.6 points, thus SCORAD decreased by 82%, which meets the criteria for significant improvements.

Example 3. Patient, 30 years. Ds: Disgestrotical eczema of the hands. Evaluation index DASI=36 points, which corresponds to the criterion disgidroticheskuyu eczema severe.

Topical treatment is applied on the affected skin of the left hand of zinc ointment. On the right hand put the means of external therapy in the form of ointments, enriched xenon. Materials receive according to the following formula:

Rp.: Lanolini anhydrici

Vaselini aa 15,0

M.f. ung.

D.S. Basis ointments for ozonation xenon.

Outdoor treatment is applied in an equal amount to the affected areas 2 times a day, morning and evening, together with the use of primary care.

The patient is thermometry pathological lesions, and assessment of the clinical picture index of the area affected and the severity of the disease when disgestrotical eczema DASI.

- On the 2nd day of treatment: right DASI=24 points, left DASI=36 points; indicators thermometry decreased to a greater extent right on 1,38°C, left by 0.19°C.

- On the 7th day of treatment: right DASI=6 points left DASI=12 points. Due to the fact that the evaluation index DASI right decreased by 83.3%, left 66.7%, which is 1.25 times more, and pokazateli thermometry on the right indicate the reduction of inflammatory activity by 2.57°C, and on the left of 1.05°C, an increase of 1.52°C, resolved as external therapy to apply the tool in the form of ointments, enriched xenon.

Indicators of temperature (Δt°)*
day Right 1/2 Left 1/2
0 36,03 35,95
2 34,65 35,76
7 33,46 34,9
21 31,37 31,35
* - thermometry is performed on abnormal foci of shibatani surface of the elbow joints. Measurements performed in 11 points pathological lesions using the apparatus of THIS Thermo Diagnostics and further calculating Δt°C.

At discharge on the 21 day evaluation of the clinical picture index DASI is 1 point, so DASI decreased by 97%, which meets the criteria for significant improvements.

Example 4. Patient E., 20 years. Ds: Acne, papules-pustular form, severe. Sick during the 6 years. Previously used drugs topical retinoids, antibiotics, benzoyl peroxide. Significant improvements have not occurred.

Topical treatment is applied on the left half of the face, neck, back, chest, 10% sulfur ointment. On the right half of the skin of these areas cause the tool of external therapy in the form of ointments, enriched xenon. Materials receive according to the following formula:

Rp.: Lanolini anhydrici

Vaselini aa 15,0

M.f. ung.

D.S. Basis ointments for ozonation xenon.

Outdoor treatment is applied in an equal amount to the affected areas 2 times a day, morning and evening, together with the use of primary care.

The patients were thermometry morphological elements, as well as evaluation of the clinical picture.

- On the 2nd day of treatment: right papules much settled, turned pale; left speakers are not marked.

- Day 7: right - morphological elements of an inflammatory nature was allowed to stagnant spots pale pink color, fresh skin rash no, left - single papules slightly settled, remains hyperemia elements arose 2 fresh papular element on the skin projection of the lower jaw; the indicators thermometry indicate the reduction of inflammatory activity in the skin right at 3.9°C, left at 0.7°C, which 3,21°C more, and therefore decided in quality is TBE external therapy to apply the tool in the form of ointments, enriched xenon.

Indicators of temperature (Δt°)*
day Right 1/2 Left 1/2
0 of 35.27 35,13
2 34,15 34,83
7 32,88 34,43

* - Thermometry is performed on a papular elements of the facial skin. Measurements are 6 points on the right half of the face and 6 points on the left half using the apparatus of THIS Thermo Diagnostics and further calculating Δt°C.

At discharge 30 day observed decrease of inflammatory cells by 50%, which meets the criteria for clinical improvement. After 6 months of therapy, which is applied to the xenon in the form of ointments, regression of the clinical picture was more than 75%, which meets the criteria for significant improvements.

When evaluating the effectiveness of treatment of patients with acne by means of external therapy, obocaman the m-xenon, under the proposed method, we obtained the following results:

- in 25.7% of patients reported a significant reduction of the inflammatory response on the 2nd day of use of xenon in the form of ointments;

74.3% on the 7th day is the resolution of inflammatory cells;

in 83% after 14 days of application do not arise fresh elements.

The present invention is applied in 26 patients, and obtained the technical result consists in the reduction of treatment time.

Sources of information

1. Milevsky YEAR, Pesterev PN. Psoriatic arthritis. - 1996

2. Volkov E.N. Atopic dermatitis. The attending physician. - 2006 - No. 9.

3. Adaskevich VP Acne vulgar and pink. - 2005

4. Skripkin J.K. Skin and venereal disease. - 1995

5. Potekaev NN. Acne and rosacea. - 2007

6. Sagmeister IA, dovzhanskiy SR Treatment of skin diseases. 1990 -

7. Suslov NI, Spizman M.N., Potapov V.N. The use of xenon in medicine. - 2009

The use of xenon in the form of funds for external therapy of chronic recurrent inflammatory skin diseases, obtained by saturation of fatty basis xenon purity.

 
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