Agent antiactinomycilline for treating actinomycosis and necrobacillosis in farm animals |
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IPC classes for russian patent Agent antiactinomycilline for treating actinomycosis and necrobacillosis in farm animals (RU 2475244):
 Method of producing heterocycle-substituted pyridine derivatives / 2474581
Invention relates to a method of producing heterocycle-substituted pyridine derivatives of general formula (I)
 Stable dosage form for local application containing voriconazole / 2472510
Dosage form for local application in the form of cream or ointment contains as effective amount of voriconazole or its pharmaceutically acceptable salt, or a pharmaceutical carrier. Said dosage form of voriconazole contains max. 3 wt % of water. What is also described is a method for preparing the dosage form of voriconazole for treating local and non-systemic mycotic infections in an individual.
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Polypeptide compounds contain cyclohexyl methyl amino groups or piperidyl methyl amino groups in the structure.
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Present invention relates to peptides having antibacterial and endotoxin-neutralising activity, having general formula (Xaa1)M-(Xaa2)o-Xaa3-(Xaa4)p-(Xaa5)Q-(Xaa6)M-(Xaa7)R-(Xaa8)S.
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Invention relates to novel heterocyclic radicals of formulae
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Invention relates to a quinazoline derivative of general formula [1], or a pharmaceutically acceptable salt thereof
Preparation reganide for treating and preventing diseases in mammals / 2464025
Invention refers to a preparation for treating and preventing diseases in mammals on the basis of a germanium-organic compound of formula C24H10N3O13Ge which is a pyridine dicarboxylic acid derivatives and possess immunomodulatory, antibacterial, antimycotic and anthelminthic activity.
 Compositions and methods of treating zygomycosis and other fungoid diseases / 2464024
Invention concerns the use of compositions for preparing a drug for treating or preventing zygomycosis. The compositions contains at least one iron-chelating compound. Also, the compositions may additionally contain at least one antimycotic agent. The iron-chelating compounds are represented by the compounds other than siderophore or xenosiderophore with respect to the given fungoid diseases, namely deferiprone and deferasirox. The antimycotic agents being parts of the compositions may contain polyene azol or echinocandin antimycotic agents.
 Cyclic antimicrobial peptides / 2463308
Invention relates to cyclic cationic peptides and use thereof in treating fungal infections.
 Antifungal gel for local application / 2457831
Invention relates to medicine and pharmaceutical industry, and deals with antifungal composition in form of gel for local application. Antifungal gel composition includes fluconazole in amount 0.1-5.0 wt %, one or more dissolving adjuvants in amount 0.5-25 wt %, hydrophilic polymer in amount 0.05-5.0 wt % and purified water in amount 20-96 wt %.
Method of treating acute and aggravated chronic laryngitis / 2474431
Invention refers to medicine and aims at treating acute and aggravated chronic laryngitis. What is involved is specific antibioticotherapy per os with additional examination of microflora starting from the 3rd-5th day of the therapy followed by instillations of specific, result-related bacteriophagues into the larynx in the amount of 0.5-1.0 ml in acute laryngitis for 7-10 days, and in aggravations for 10-14 days.
Universal vaccine for treating and preventing lyme disease applicable in human and veterinary science, and method for preparing it / 2472525
Invention refers to medicine, and concerns a universal vaccine for treating and preventing Lyme disease to be applied in veterinary science, based on a whole-cell bacterial vaccine or bacterial lysates or purified preparations, containing the three most pathogenic genospecies Borrelia burgdorferi sensu stricto, Borrelia afzelii and Borrelia garinii, each of which simultaneously contains both immunogenic protective proteins of the outer membranes OspA and OspC.
Moxifloxacin aqueous formulation for parenteral introduction / 2472507
Present invention refers to chemical-pharmaceutical industry and presents a moxifloxacin aqueous formulation for parenteral introduction containing an active substance: moxifloxacin hydrochloride, water for injections and other ingredients used for parenteral introduction differing by the fact that said ingredients are presented by sodium ascorbate and sodium metabisulphite in the following proportions, g/l: moxifloxacin hydrochloride 15-25; sodium ascorbate 0.05-1; sodium metabisulphite 0.1-2; water for injections up to 1 l.
 3-amino-6-(1-aminoethyl)tetrahydropyrane derivatives / 2471795
Invention refers to new antibacterial compounds of formula I
 Mutant antigens gas57 and gas57 antibodies / 2471497
Group of invention refers to medicine, particularly to producing a mutant antigen GAS57 containing an amino acid modification in two or more positions of amino acids specified in a group consisting of consisting of amino acids D151, H279 and S617 wherein said positions of amino acids are numbered according to SEQ ID N0:1 which is not able to split IL-8 and analogous substrates with keeping an ability to provide protection of the infections caused by S. pyogenes. The group of inventions also comprises a nucleic acid molecule coding a purified mutant antigen GAS57, a method for producing a mutant antigen, a composition and a method for producing it, a method for treating or preventing an infectious disease caused by S. pyogenes. Said mutants may be used inter alia in vaccine compositions.
Method for preparing composition for injections containing sodium cevtriaxone and sodium tazobactam / 2471484
Method for preparing a composition for injections containing sodium cevtriaxone and sodium tazobactam involves the following stages: (a) suspension of raw materials, i.e. sodium cevtriaxone, sodium tazobactam, sterilised water for injections, mixed solution of ethyl acetate and isopropyl alcohol, and anhydrous ethanol in mass relation making 3-5:1:2:5:9, with volume relation of ethyl acetate to isopropyl alcohol making 1:2-4; (b) dissolution of sodium cevtriaxone and sodium tazobactam in sterilised water for injections with added activated hydrocarbon and filtration; (c) addition of the mixed solution of ethyl acetate and isopropyl alcohol to the filtrate and agitation of the mixture; addition of a seed crystal of sodium cevtriaxone to the solution for crystallisation initiation; and finally washing of the crystals in anhydrous ethanol and crystal drying; and (d) lyophilisation to form the composition for injections containing sodium cevtriaxone and sodium tazobactam.
 Complex composition of chitosan succinate and chlorhexidine possessing antibacterial and wound healing effect / 2471477
Invention refers to medicine. What is described is a complex of chitosan and dioxydine with chlorhexidine at mass ratio of chitosan succinate with dioxidine 4.25-6:1 and chlorhexidine 60-85.0:1 respectively.
Method for integrated treatment of maxillofacial abscesses and phlegmons in children by ointment with furacilin, lidocaine and dibunol / 2470629
Offered invention refers to medicine, namely dentistry, and may be used for treating children suffering maxillofacial abscesses and phlegmons. That is ensured by opening of a suppurative focus, wound bathing and drainage. With underlying conventional antibacterial therapy, an ointment containing furacilin, lidocaine and dibunol as active agents and a styrene maleic anhydride copolymer, Lutrol F-127 and purified water in certain proportions as an ointment base is introduced in the suppurative cavity. Furacilin - 0.2, Lidocaine - 5.0, Dibunol - 5.0, Styrene maleic anhydride copolymer - 2.0, Lutrol F-127 2.0 and Purified water to 100.0.
Composition for treatment or prevention of gastrointestinal infection / 2469735
Composition for treatment and/or prevention of infection with gastrointestinal pathogens and/or disease of mammals, associated with infection by said pathogens, contains lipid, protein and hydrocarbon part, where lipid part provides from 5 to 50% of total number of calories, protein part provides from 5 to 50% of total number of calories and carbohydrate part provided from 15 to 90% of total number of calories. Protein part contains: (i) pea protein hydrolysate and (ii) at least one source of nitrogen, selected from the group, consisting of milk proteins, milk protein hydrolysate, egg protein and egg protein hydrolysate.
 3-(2-bromophenyl) and 3-benzyl-4,5,6,7-tetrahydroindazole hydrochlorides, antimicrobial agent based thereon / 2469027
Present invention relates to organic chemistry and specifically to novel biologically active indazole compounds: 3-(2-bromophenyl)-4,5,6,7-tetrahydroindazole hydrochloride (1a) and 3-benzyl-4,5,6,7-tetrahydroindazole hydrochloride (1b) of general formula:
Skin care compositions / 2475232
Invention refers to cosmetology and represents a skin care composition characterised by the fact that when exposed to IR light said composition transmits a considerable portion, or does not considerably transmit or does not reflect said IR light; said composition contains water in an amount of approximately 40 wt % to approximately 60 wt % of the composition, a silicone emulsion in an amount of approximately 10 wt % to approximately 45 wt % of the composition, approximately 20 wt %> of the ethanol composition, to approximately 20 wt % of the glycerol composition, to approximately 20 wt % of the hydramazon passiflora composition, and to approximately 20 wt % of the phytexcell jujube composition, to approximately 5 wt % of the glycerolglycerylacetate/acrylic acid copolymer, the PVM/MA copolymer composition and to approximately 5 wt % of the glycereth-18 ethylhexanoate composition.
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FIELD: medicine, pharmaceutics. SUBSTANCE: invention relates to veterinary science. The agent contains, wt %: wildflower honey 3.0-5.0, pine turpentine 5.0-8.0, melted (cow) butter 12.0-15.0, anaesthesine 0.5-1.0, glycerol 0.5-1.5, ethanol 20.0-25.0, potassium iodide 2.0-2.5, salicylic acid 3.0-5.0, 9% vinegar 6.0-8.0, Novocaine (powder) 1.0-1.5, distilled water - the rest. EFFECT: use of the declared agent enables higher clinical effectiveness in actinomycosis and necrobacteriosis, improved immunobiological properties of animal's body, reduced length of recovery. 1 tbl, 4 ex
The invention relates to veterinary medicine, namely to the means of treatment of actinomycosis and nitrobacteria farm animals. At the present time the problem of treatment of such diseases in cattle, as actinomycosis is a chronic infectious disease of animals caused by actinomycete (radiant fungi), the main form of manifestation of which is an infectious granuloma. Well-known drug for the prevention and treatment of microbacteria animals aqueous solution of metadatamanager water, methylaminoethanol fractions of high-boiling product is treated limbs of animals (patent RU №2011380, AK 31/05, 1994). Known use in veterinary practice for the treatment of fungal diseases of animals of sulfur (temporary instruction on using an integrated treatment of demodicosis, 1990). Known medical veterinary drug, where as the active substance - antiseptic - used elementary sulfur and filler (U.S. Pat. RU # 2030868, AK 31/05, 1995). However, these drugs are not sufficiently high therapeutic effect, a narrow spectrum of action and a long duration of treatment. It is also known for the treatment of deep, extensive burns and infected wounds and ulcers and it is balm ointment, which content is t politlely floral honey, the oleoresin of pine and ghee (cow) oil (U.S. Pat. RU # 2168999, AK 35/64, AK 9/06, OR 17/02 2001). Although this ointment, it is most similar to that proposed, and softens and dissolves the inflammatory process, but not enough neutralizes the vast deep of the affected tissue by micelle (thread) actinomycosis. In the claimed invention, the aim was to obtain such remedy for the treatment of actinomycosis, which would completely neutralize and enhance the immunobiological properties of the organism of animals and reduce the time of recovery. This is achieved by the fact that the remedy for the treatment of actinomycosis and nitrobacteria farm animals, including politlely floral honey, SAP pine, ghee (cow) butter, impose additional anesthesia, glycerin, ethyl alcohol, potassium iodide, salicylic acid, vinegar 9%, novocaine (powder) and distilled water in the following ratio, wt.%:
The features that distinguish the proposed remedy is closest to him of a patent of the Russian Federation No. 2168999, characterized by the presence of benzocaine, glycerin, ethyl alcohol, potassium iodide, salicylic acid, vinegar 9%, novocaine (powder) and distilled water, which can improve therapeutic effect, immunological properties, to enhance the regenerative process, neuro-vascular reactions of the affected tissues, enhance the bactericidal action of the tool. The proposed tool Anticlimatically" obtained as follows. Salicylic acid, potassium iodide dissolved in ethyl alcohol, benzocaine, novocaine in distilled water, then in acetic acid 9%acid and glycerine. Then the resulting solutions are mixed, and the resulting solution DOB is given in preheated in a water bath at a temperature of 45-50°C politlely floral honey, the oleoresin of pine and ghee (cow) butter, mix thoroughly until a homogeneous mass and Packed. The components are mixed according to the formulations specified in the table.
Only this recipe mixing provides 100% decontamination and recovery of animals, using the formulation is less than the minimum is not reached the required efficiency, and the use of the formulation is greater than the maximum impractical, since the effectiveness of the treatment remains the same - i.e. 100%. Liquid warm solution "Anticlimatically" once imposed under the base actinomycin located in the region of the head, neck and other parts of the body in depth from 0.5 to 12 cm in diameter from 3 to 12 cm in 2-4 points in the dose of from 5 to 30 ml (one point 4-8 ml), in the cavity of the abscess from 4 to 8 ml. of a Single injection of the drug under the base actinomycosis or in the center of the abscess provides complete disinfection and neutralization of infected tissues, does not distort their trophic and functional ability of the neuro-vascular reactions, completely preserved productivity of animals. Treatment of actinomycosis was conducted on the cattle of different age 30 farms in 16 districts of the Republic of Tatarstan. Example 1. In the collective enterprise "Cheremuhovskoe" RT at 500 head d is inih cows were actinomycosis in the head and neck, the depth of 10-12 cm, which were removed surgically, part 2 of the surgeon, 6 clamps, elapsed time per animal was 2.5 hours, the same time required for re-processing, and, in addition, require a large number of medical and dressings. Used in the form of a drain in the wound balm ointment (taken as a prototype .RU No. 2168999), the recovery process of damaged tissue occurs within 7-10 days, but left Druze radiant fungus cause maturation of the new granulomas. Example 2. On the same site at 158 cows were actinomycosis in the head and neck area by the depth of 10-12 cm, under the base actinomycosis was introduced warm liquid solution proposed means of Antivaccination" 4-6 points from 5 to 30 ml, in the center of the abscess from 4 to 8 ml once daily for 2-3 days after administration of the drug was increased swelling of the affected area, which on the fourth day decreased in size. Deep granuloma was inkapsulirovanie, i.e. the formation of new metastases were stopped. The introduction of the drug was carried out by a single latch, and its introduction is spent only 3 minutes per animal, was achieved 100% recovery of the animals, was fully preserved productivity and in the future, a new metastasis was not observed. The use of the 3. In the cooperative sector was the treatment of actinomycosis 60 milking cows, 160 heifers, 40 calves. Actinically were located subcutaneously, mimisan depth from 0.5 to 12 cm, the size of diameter from 3 to 8-12 cm in different degrees of maturation, as well as abscesses revealed. Under the base actinomycin located in the head and neck region, introduced the proposed tool Anticlimatically" in a dose of from 5 to 30 ml, and in the cavity of the abscess from 4 to 8 ml After administration of the drug on the sheet injection for 2-3 days there was a slight swelling, which on the fourth day decreased in size, General condition of the animals is satisfactory, continued productivity. Actinomycosis that are in the initial process of maturation, completely broken up and dissolved, and in the period abstsedirovaniya - was found to be cleansed, not infecting the environment remained insignificant scars, and superficial metastases actinomycosis have been fully decontaminated. Thus, therapeutic action, the proposed means "Anticlimatically" decontamination Drozdy actinomycosis single administration under its base and into the cavity of the abscess give 100% decontamination and recovery animals. Example 4. Were treated sick animals microbacterium proposed means "Anticlimatically the m in 30 farms in 16 districts of Tajikistan. The drug was administered subcutaneously once in the form of heat in the region of the Corolla in the dose of 10 to 20 ml in 4 points from 3 to 5 ml in a single point, depending on the extent of damage. After administration of the drug at the injection site on the 2nd day there was a slight swelling which disappears at 4-6 days, and on 6-8 day was gradually rejected. On 12-16 day the healing process was complete recovery of the affected tissues. The efficacy was 98.5 per cent. The proposed tool Anticlimatically" was successfully used in the treatment of acute and chronic inflammatory processes in its external use in the form of a compress. For the treatment of actinomycosis and nitrobacteria farm animals, including politlely floral honey, SAP pine, ghee (cow) butter, characterized in that it additionally contains benzocaine, glycerin, ethyl alcohol, potassium iodide, salicylic acid, vinegar 9%, novocaine (powder) and distilled water in the following ratio, wt.%:
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