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Quinazoline derivative and pharmaceutical preparation. RU patent 2464263.
Quinazoline derivative and pharmaceutical preparation. RU patent 2464263.

FIELD: chemistry.

SUBSTANCE: invention relates to a quinazoline derivative of general formula [1], or a pharmaceutically acceptable salt thereof [1], where R1-R6 assume values given claim 1, except compounds in which R5 is hydrogen and R6 is -NH2. The invention also relates to a pharmaceutical composition having the activity of an antipruritic agent, containing as an active ingredient said quinazoline derivative or pharmaceutically acceptable salt thereof.

EFFECT: obtaining a novel quinazoline derivative with low irritant action on skin and excellent action of significant suppression of scratching behaviour, as well as an antipruritic agent containing such a quinazoline derivative as an active ingredient.

9 cl, 250 ex, 7 tbl

 

 
IPC classes for russian patent Quinazoline derivative and pharmaceutical preparation. RU patent 2464263. (RU 2464263):

C07D413/14 - containing three or more hetero rings
C07D413/12 - linked by a chain containing hetero atoms as chain links
C07D405/14 - containing three or more hetero rings
C07D405/12 - linked by a chain containing hetero atoms as chain links
C07D403/12 - linked by a chain containing hetero atoms as chain links
C07D401/14 - containing three or more hetero rings
C07D401/12 - linked by a chain containing hetero atoms as chain links
C07D239/94 - Nitrogen atoms
A61P7 - Drugs for disorders of the blood or the extracellular fluid
A61P5/16 - for decreasing, blocking or antagonising the activity of the thyroid hormones
A61P37/06 - Immunosuppressants, e.g. drugs for graft rejection
A61P35 - Antineoplastic agents
A61P31/10 - Antimycotics
A61P3/10 - for hyperglycaemia, e.g. antidiabetics
A61P27/14 - Decongestants or antiallergics
A61P25/18 - Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
A61P25/08 - Antiepileptics; Anticonvulsants
A61P17/04 - Antipruritics
A61P13/12 - of the kidneys
A61P1/16 - for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
A61K31/517 -
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