Method for preparing free autograft for burn wound |
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IPC classes for russian patent Method for preparing free autograft for burn wound (RU 2466714):
Method for producing biopreparation ferrigel / 2466713
Method for producing a biopreparation involves mixing of ferric oxyhydroxide with a water-soluble polymers and ultrasonic treatment of the suspension differing by the fact that there are used ferric oxihydroxide gel (FOH-gel) recovered at the stages of underwater deironing, the water-soluble polymer, and additionally glycerol is introduced in the following proportions, wt %: FOH-gel 50-60; water-soluble polymer 2.5-3; glycerol 10-15; water to 100. The water-soluble polymer is presented by a polymer specified in a group of polyvinyl alcohol (PVA), polyethylene glycol (PEG), polyvinylpyrrolidone (PVP) or polyacrylamide (PAA). The biopreparation possesses wound healing, bactericidal, regenerative and adsorption properties.
Medication for treating purulent wounds / 2465899
Invention relates to pharmaceutical industry, in particular to medication for treatment of purulent wounds by method of photodynamic therapy. Medication for treating purulent wounds by method of photodynamic therapy in form of gel, which includes zinc polycholinyl phthalocyanine, hydroxyethylcellulose, dimethylsulfoxide or benzalconium chloride (alkylbenzyldimethylammonium chloride), block-copolymer of ethylene oxide and propylene oxide or polyethyleneglycol, water, taken in specified quantity. Medication for treatment of purulent wounds by method of photodynamic therapy, representing film, obtained by drying of gel described above.
 Local application and erythropoietin preparations for skin wound healing / 2465003
Invention refers to medicine and pharmaceutical application and represents a gel or viscous composition applicable for local wound healing on injured skin, containing erythropoein (EPO) and at least one swelling gel-forming polysaccharide in the concentration of 0.4-4 wt %/wt specified from one or more than one member of the group consisting of: hydroxyethyl cellulose, hydroxymethyl cellulose, carboxyethyl cellulose, carboxymethyl cellulose which can be prepared by mixing EPO in a lyophilised or suspended form with the pre-swelled polysaccharide of viscosity less than 5000 mPa*s, and initiating complete swelling wherein completely swelled polysaccharide has viscosity 20000-60000 mPa*s, and EPO is found in the concentration of 100-500 IU/g of the gel composition wherein said mixing is ensured by EPO diffusion in a gel for at least 24 h.
 Method for making resorbed polylactide matrix for cell culture and implantation for wound healing / 2464987
Invention refers to biotechnology and medicine and represents a method for making a resorbed polylactide matrix for cell culture and implantation for wound healing that involves preparing a resorbed hydrophilic porous polylactide matrix uniformly coated with type 1 microfibrillar collagen; for this purpose the hydrophilic porous polylactide matrix 13 mcm tp 15 mcm thick with the pore diameter of 2 mcm to 3 mcm is prepared and then coated with 0.01% type 1 collagen in 0.1% acetic acid, incubated for 30 minutes at room temperature; thereafter, the matrix surface is washed in phosphate-buffered saline pH 7.4 to remove protein not bound with a substrate; the procedure of coating with the type 1 collagen solution is performed for two more times; the hydrophilic surface of the porous polylactide matrix uniformly coated with microfibrillar collagen structures of the diameter of 10 nm to 20 nm is applicable for human keratinocyte culture.
 Method for preparing agent for stimulation of skin repair regeneration / 2463063
Invention refers to medicine and pharmacology and represents a method for preparing an agent for stimulation of skin repair regeneration involving the use of pre-fractionated and lyophilised autoblood plasma components, differing by the fact that fractionation of blood plasma components are followed by anion exchange chromatography; the components of molecular weight 20-30 kDa collected on the anion exchanger, dialysed, lyophilised, and introduced in the ratio of 6:1000 into an ointment compound, and applied on the skin surface and within an injury.
Method for making hydrocolloid bactericidal dressing / 2462270
Invention refers to medicine. What is described is a method for making a hydrocolloid bactericidal dressing with wound-healing and antimicrobial properties. The dressing represents a structure of a number of layers fastened to each other. The layer adjoining the wound represents a perforated polyethylene film; it is coated with a hydrocolloid plate of acryl compounds with added glycerol covered with a non-woven layer with deposited dialdehydecellulose microfibers with the immobilised enzyme lysoamidase. An upper protective layer represents a perforated polyethylene film.
Method for burn wound healing / 2460555
Invention relates to medicine and may be used for burn wound healing. That is ensured by exposure of a wound surface to laser light in process of 1-2 sessions of photodynamic therapy. The sessions involve wound irrigation with the antiseptic, drying, coating with a β-hemostopane-5 tissue for 24 hours. After the β-hemostopane-5 tissue is removed, the wound surface is coated with Photoditasine immobilised on an amphiphilic polymer. It is left for 30-40 minutes, and photosensitiser residues are washed from the wound surface. The wound surface is exposed at first to red laser light at wave length 660±3 nm, power density 1.0 Wt/cm2 and energy density 25-30 J/cm2. The wound surface is exposed to blue laser light at wave length 450±20 nm, power density 0.25 Wt/cm2 and energy density 10 J/cm2. Then the wound surface is coated with the pre-wetted β-hemostopane-5 tissue.
 Preparation fastening wound healing / 2460532
Invention refers to medicine. The preparation represents a solution of low-molecular chitosans in hydrogel containing methyl cellulose (MC-100) and Nipagin. The preparation represents a dispersed suspension of copper nanoparticles, particle size 33.8÷103 nm; oxide film thickness 6÷10 nm and phase composition: crystalline copper 67-96% and copper oxide CuO - 4÷33%, or more oxidised copper nanoparticles having the following characteristics: particle size 77÷119 and phase composition: crystalline copper 0.5÷3.3%, CuO - 27.1÷90.0% and Cu2O -9.05÷69.50 in hydrogel containing methyl cellulose (MC-100), Tween-80, Nipagin and the solution of solution of low-molecular chitosans, the suspension of chitosan nanoparticles.
 Method and system of determining arewa and degree of patient affection and rendering first aid in case of burns by means of visible light spectrum and ultra sound / 2459574
Group of inventions relates to medicine. Device, moving above patient with bright white light, photographs, registers and transmits onto display screen total area of wound surface of burns, including numerical ratio in percent, with possibility of enlarging the most affected sites, for logging and monitoring dynamics of wound surface therapy. Boundaries of affection degrees are determined under intensive blue colour. Depending on affection degree specialist selects therapy for each section. Depth of skin and organ affection is also determined by device by means of ultrasonic scanner and in case of necessity depth of burn affection is displayed on monitor in two-dimensional image and snapshots for comparative dynamics of recovery are made. After determining area and degree of affection fine-aerosol of antiseptic preparation is dispersed for quick reduction of wound surface temperature and prevention of infectious complications. After application of antiseptic preparation above entire wound surface performed is phototherapy with blue spectrum with simultaneous air ventilation for reducing pain, lowing down temperature of wound surface, recovery of its microcirculation and air ablation of necrotic tissues. After required surgery medication with film-forming suspension is applied by device in form of fine aerosol, which again leads to reduction of burn surface temperature and prevents "greenhouse effect" of wound. After application of medication device switches on blue irradiators, spectrum of which reduces pain, restores microcirculation, activates medication and increases cell metabolism, simultaneous switching on of ultrasonic transmitter increases permeability of pores and membranes of skin and epithelium cells for medications. After the end of procedure air ventilation is switched on.
Stabilised pharmaceutical composition for treating diseases caused by venous insufficiency / 2458694
Invention refers to medicine and pharmacy, and represents a pharmaceutical composition possessing venotonic, wound healing, anti-inflammatory action, containing a therapeutically effective amount of sodium heparin in a combination with Troxerutin and Dexpantenol, and as auxiliary substances - propylene glycol, trometamol, preserving agent and purified water, differing by the fact that it additionally contains UV filter Escalol 567, organosilicone elastomer DC 9045, organosilicone emulsifier DC 5329, cyclomethicone DC 345, antioxidant Tinogard NOA, acrylate emulsion of copolymer Salcare SC80, and a preserving agent is Sharomix MCI with the ingredients taken in certain proportions, wt %.
Method for producing biopreparation ferrigel / 2466713
Method for producing a biopreparation involves mixing of ferric oxyhydroxide with a water-soluble polymers and ultrasonic treatment of the suspension differing by the fact that there are used ferric oxihydroxide gel (FOH-gel) recovered at the stages of underwater deironing, the water-soluble polymer, and additionally glycerol is introduced in the following proportions, wt %: FOH-gel 50-60; water-soluble polymer 2.5-3; glycerol 10-15; water to 100. The water-soluble polymer is presented by a polymer specified in a group of polyvinyl alcohol (PVA), polyethylene glycol (PEG), polyvinylpyrrolidone (PVP) or polyacrylamide (PAA). The biopreparation possesses wound healing, bactericidal, regenerative and adsorption properties.
Medication for treating purulent wounds / 2465899
Invention relates to pharmaceutical industry, in particular to medication for treatment of purulent wounds by method of photodynamic therapy. Medication for treating purulent wounds by method of photodynamic therapy in form of gel, which includes zinc polycholinyl phthalocyanine, hydroxyethylcellulose, dimethylsulfoxide or benzalconium chloride (alkylbenzyldimethylammonium chloride), block-copolymer of ethylene oxide and propylene oxide or polyethyleneglycol, water, taken in specified quantity. Medication for treatment of purulent wounds by method of photodynamic therapy, representing film, obtained by drying of gel described above.
Homeopathic composition for treating mastopathy, painful inflations, premenstrual inflamed breast warts, as well as benign neoplasms / 2463068
Invention refers to medicine, namely preparing a homeopathic ointment with wide spectrum of action. The homeopathic composition for treating mastopathy, painful inflations, premenstrual inflamed breast warts, as well as benign neoplasms represents an ointment containing celandine, cedar, wild rosemary, pokeberry, plantain essences, graphite D6, fumitory D6 dilutions, and arespol-margarine-lanoline base.
Method for preparing agent for stimulation of skin repair regeneration / 2463063
Invention refers to medicine and pharmacology and represents a method for preparing an agent for stimulation of skin repair regeneration involving the use of pre-fractionated and lyophilised autoblood plasma components, differing by the fact that fractionation of blood plasma components are followed by anion exchange chromatography; the components of molecular weight 20-30 kDa collected on the anion exchanger, dialysed, lyophilised, and introduced in the ratio of 6:1000 into an ointment compound, and applied on the skin surface and within an injury.
 Diclofenac gel / 2463038
Invention relates to composition for pain treatment, as well as for treatment of osteoarthritis in patient with joint pain. Claimed composition includes 0.1-10 wt % of non-steroid anti-inflammatory compound - sodium diclofenac or sodium diclofenac solution, 25-60% wt dimethylsulfoxide, ethanol, propylene glycol, thickening agent, selected from hydroxypropylcellulose and polymers-carbomers and glycerol in case of thickening agent is carbomer, water and has viscosity equal to 500-5000 centipoise. Invention also relates to medication for treatment pain, as well as treatment of osteoarthritis in patient, with joint pain, which contains said composition.
Gel showing anti-inflammatory, analgesic, wound healing action (versions) / 2458684
Invention refers to pharmaceutical industry, and concerns more than one version of the compositions showing anti-inflammatory, analgesic, wound healing action which are applicable for treating dermatites, wounds, bruises, and locomotor diseases. All versions of the compositions contain a moulding base, Mumiyo, and also a complex phytoextract.
 Gel possessing anti-inflammatory, immunotropic, antiallergic and wound healing action / 2457864
Invention refers to chemical-pharmaceutical industry, medicine and veterinary science, particularly new drugs in the form of a gel for inflammatory diseases of various geneses. The gel possessing anti-inflammatory, antiallergic and wound healing action, characterised by the fact that it contains peptides associated with phospholipids and prepared of cod liver, a gelling agent, a wedding agent, a pH adjustor, a preserving agent and purified water. The presented gel possess manifested anti-inflammatory, antiallergic, immunotropic and wound healing action. The gel has essentially no side effects common to the prior drugs of the same purpose.
Stabilised pharmaceutical composition with antiviral action / 2457843
Invention relates to chemical-pharmaceutical industry and represents pharmaceutical composition possessing activity, containing therapeutically efficient quantity of acyclovir (or its salt or ester), as auxiliary substances, hydrophobic component, propyleneglycol, emulsifier and water, characterised by the fact that it additionally contains UV-filter Escalol 567 sodium organic elastomer DC 9045, Cyclometicon DC 345, keratolytic urea, trometamol, preservative. Pharmaceutical composition is manufactured in drug form of gel. Pharmaceutical gel corresponds to requirements of State Pharrmacopoeias of XI and XII editions.
 Antifungal gel for local application / 2457831
Invention relates to medicine and pharmaceutical industry, and deals with antifungal composition in form of gel for local application. Antifungal gel composition includes fluconazole in amount 0.1-5.0 wt %, one or more dissolving adjuvants in amount 0.5-25 wt %, hydrophilic polymer in amount 0.05-5.0 wt % and purified water in amount 20-96 wt %.
Compositions for local application / 2457830
Claimed invention relates to chemical-pharmaceutical industry, and deals with single-phase pharmaceutical compositions for local application, as well as sets and methods of application and introduction. Compositions include biologically active agent carrier for delivery, which contains, at least, non-polymer crystallisation inhibitor and film-forming agent; and volatile solvent; where in composition biologically active agent is present in partially saturated state, in carrier for delivery biologically active agent is present in oversaturated state, and crystallisation inhibitor is capable of slowing down crystallisation of biologically active agent in carrier for delivery. Terbinafine and acyclovir belong to biologically active agents.
 Antiperspirant deodorant compositions / 2466712
Composition containing at least one active component specified in at least one antiperspirant active component and at least one deodorant active component; at least one hydrocarbon of formula CnH2n+2, wherein n has the value of approximately 20 to approximately 100, and hydrocarbon has at least 90% of a linear structure; at least one soya oil having an iodine number of more than 0 to approximately 20; and at least one silicone compound.
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FIELD: medicine. SUBSTANCE: 10 minutes before grafting, donor skin 0.2-0.3 mm is coated with Tisol gel mixed with ozonised sea buckthorn oil. Then, 10 minutes later, the residual mixture is removed; the donor skin surface is treated with spirits, and grafting procedure is started. EFFECT: method provides better microcirculation within the donor area, ensures bactericidal action, higher tissue and graft oxygenation. 1 ex
The present invention relates to medicine, namely to combustology, and can be used in the preparation of the donor area of skin, you need to take grafts. It is known that tyazheloobozhzhennykh sharply reduced consumption by the tissues of oxygen, which leads to hypoxia. Persistent soft tissue hypoxia adversely affects the timing of donor healing of wounds and reduces oxygenation cutting grafts, leading to lysis and greatly aggravates the patient's condition, lengthens the healing time of donor wounds and requires re-autodermoplastiki. In this regard, the search for ways to improve microcirculation and increase oxygenation in the area of donor skin area, scheduled to take grafts, remains an urgent task. The known method of preparing graft for free autodermoplastiki burn wounds, which consists in the treatment of the donor area by a stream of helium plasma with an electric current of 30 a, a voltage of 30 V at a gas pressure of 0.1 kg/cm2from a distance of 15 cm from the nozzle of the plasmatron to the surface of the skin with exposure time of 20 sec on one field daily for 5 days (patent RF №2134134, 1999). The disadvantage of this method is the need for bulky, expensive equipment and training is the illusion to work on the torch. In addition, the duration of procedures that cover at least 5 days, at a limited area of preparation of donor skin (2 plots of 200 cm2), increases the recovery of the skin. As a prototype of the chosen method of preparation of the graft for free autodermoplastiki burn wounds, is the impact of the ultrasonic waveguide to the skin of the proposed donor site through vaseline oil for 10 minutes over 5 days before surgery (see Said V.L. Experimental and clinical reasoning training skin autotransplants in the treatment of patients with thermal burns. Abstract. dis. ... candidate honey. Sciences. - Vitebsk, 1986. 18 C.). However, RAS has no independent bacteriostatic effect on microorganisms and to contact the waveguide with the tissue surface requires constantly renewing the staging environment. The task of the invention is the improvement of the method. The technical result - improvement of microcirculation in the area of donor skin area, ensure bactericides, increase oxygenation of tissues and cutting grafts. The technical result is achieved in that in the method, including the impact on the prospective donor site on it for 10 minutes before taking the tra is of plantaton put a layer of 0.2-0.3 mm medicinal mixture of gel Tizol" with ozonized oil with ozone 200-250 mcg. The method of preparation of the graft for free autodermoplastiki as follows: 10 minutes before taking grafts on the skin of the donor area with a layer of 0.2-0.3 mm apply the mixture of gel Tizol" with ozonated sea buckthorn oil with ozone 200-250 mcg. After 10 minutes, a mixture of residues located at the donor site, is removed using a dry sterile cloth. Then twice treated with the surface of the skin donor site alcoholic chlorhexidine 1:400 or 1% solution of itaperuna and start cutting grafts. Clinical example: B-Noy So 1, 5 months. (IB. No. 256611), was admitted to the burn centre of Nizhniy Novgorod with burn flame III-B, the degree of torso, limbs in the area of 15% of the body surface. After preparation of burn wounds the child made 2 transactions skin plasty. When performing autodermoplastiki preparation of donor skin was carried out by applying a mixture of gel Tizol" and ozonated sea buckthorn oil for 10 minutes before taking grafts. In spite of the child expressed hypoxia, which is the result of extensive deep burns, burns of the respiratory tract, the transplanted grafts on the receiving bed she had completely and donor wound healed without suppuration within 8 days, that a significant shortage of donor the skin resources allowed to re-use these sites to take grafts. The skin of the patient recovered completely, and he after 20 days was discharged for outpatient treatment The method allows to provide a complete engraftment of transplanted grafts to close the site of wounds, on average, 8 days without signs of sepsis and reduce for 3-4 days time epithelialization of donor wounds. The reduction in 3-4 days time donor healing of wounds allows you to use the repaired skin to re-cut grafts, which is especially important in patients with extensive deep burns that have a shortage of skin resources. Gel Tizol" accelerates healing processes in the skin, reduces inflammation, reduces pain syndrome. The presence of associated molecules of glycerin and titanium atom in the molecule Title provides tread, dehydrating, antiedematous and local analgesic effect. In addition, the gel structure Title with good transcutaneous action, provides the conductance through biological tissue of medicines, in particular ozonated sea buckthorn oils containing highly active biological substances and having a high bactericidal effect due to ozone. The method improves the metabolic processes in the tissues of the donor area, helping them improve oxygenate and in cutting the grafts. Applied to the skin of a medicinal mixture easily penetrates deep into the tissues and after 10 minutes the donor site for the planning area prepared for taking grafts. The method of preparation of the graft for free autodermoplastiki burn wounds by the impact of oil on the prospective donor site, wherein the donor area for 10 minutes before taking grafts put a layer of 0.2-0.3 mm mixture of gel Tizol" with ozonated sea buckthorn oil with ozone 200-250 mcg.
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