Method and system of determining arewa and degree of patient affection and rendering first aid in case of burns by means of visible light spectrum and ultra sound
SUBSTANCE: group of inventions relates to medicine. Device, moving above patient with bright white light, photographs, registers and transmits onto display screen total area of wound surface of burns, including numerical ratio in percent, with possibility of enlarging the most affected sites, for logging and monitoring dynamics of wound surface therapy. Boundaries of affection degrees are determined under intensive blue colour. Depending on affection degree specialist selects therapy for each section. Depth of skin and organ affection is also determined by device by means of ultrasonic scanner and in case of necessity depth of burn affection is displayed on monitor in two-dimensional image and snapshots for comparative dynamics of recovery are made. After determining area and degree of affection fine-aerosol of antiseptic preparation is dispersed for quick reduction of wound surface temperature and prevention of infectious complications. After application of antiseptic preparation above entire wound surface performed is phototherapy with blue spectrum with simultaneous air ventilation for reducing pain, lowing down temperature of wound surface, recovery of its microcirculation and air ablation of necrotic tissues. After required surgery medication with film-forming suspension is applied by device in form of fine aerosol, which again leads to reduction of burn surface temperature and prevents "greenhouse effect" of wound. After application of medication device switches on blue irradiators, spectrum of which reduces pain, restores microcirculation, activates medication and increases cell metabolism, simultaneous switching on of ultrasonic transmitter increases permeability of pores and membranes of skin and epithelium cells for medications. After the end of procedure air ventilation is switched on.
EFFECT: blue spectrum will make it possible to accelerate process of wound surface healing and will exclude secondary infection, ensure cytoprotective effect, activate exchange processes, improve blood supply of tissues at the level of microcirculation.
5 cl, 3 dwg
The invention relates to medicine, namely to the field of physical method for the diagnosis area and the extent of involvement of the person, first aid and subsequent treatment through the visible spectrum of light and ultrasound.
Technical progress is the emergence of new forms of energy, wide use in the home and in the production of electric current, gas, hydrocarbon fuel, lubricants and chemically active substances leads to an increase in burn injuries.
Frequency burns an average of 1:1000 per year. Burns, according to who, the frequency ranks third among other injuries. Mortality from burns in the United States, Canada, Sweden and Japan ranges up to 15.4 59,0 per thousand. In the Russian Federation in 2000 occurred 295 thousand fires, the fire killed 15877 and injured 11334 people (Lvitra, Yea. Assessment of the severity of injury in fatal burn injury. Collection of articles of materials of scientific-practical conferences 2000-2001, St. Petersburg., 2001, - s-333).
A significant part of the victims of fires delivered in the hospital with multifactor lesions, among which are most severe thermal burns of the skin. The mortality among tyazheloobozhzhennykh remains high (21,2%) even in specialized hospitals. The proportion of those killed in the resulting fire, ago the s is 38.4 per cent. While the burn problem at the present time among surgical turned into a General biological problem. (Gavrilovskaya. Forensic assessment of the role of comorbidities in the Genesis of death from burn injuries (collection of scientific articles. Riga, RMI, 1984 - Pp.118-122)).
Thermal injury are complex and poorly understood pathogenesis. With extensive and deep burns experiencing profound shifts in function and morphology of almost all major organs and systems, and the causal relationship between violation is at the cellular and subcellular level, which greatly complicates the recognition of these subtle pathological processes (Min et al. Burn disease. M.: Medicine, 1982 - p.17-21).
If the pathogenesis of these manifestations of burn disease, as thermal shock, burn intoxication, early and late pneumonia, pulmonary edema and infarction (if they are not a manifestation of burn sepsis) should in each case, taking into account the fact that for severe burn injuries typical disorders of hemostasis different stages of the disease. At the same time, complications such as ascending purulent pyelonephritis, cholangitis and pathological processes, due to the exacerbation of intercurrent chronic diseases, to put in a direct causal relationship with the received burn injuries not predstavljaet is possible. (Ary et al. Peculiarities of the course and treatment of burns in patients older than 50 years. - In the book: Materials of the IV Republic. scientific-practical conference on the problems of thermal damage. Bitter, 1982 - s.112-113).
In 95% of cases the main causes of disability are burnt contractures, adhesions, dislocations and subluxations, ankylosis, keloid hypertrophic scarring, amputation defects, burn exhaustion.
And in 5% of cases the cause of the disability is such complications of burn disease as hepatitis, nephritis, Apama pleura, the amyloidosis of internal organs and other (Say. Prospects for the development and improvement of the forensic medical service of the Russian Federation (the Materials of the V all-Russian Congress of forensic. Moscow-Astrakhan. 2000, - p.85-89).
Currently, assessment of the severity of adverse health effects when the burns are carried out in accordance with the MOH and CF RF "On determining the severity of injuries in accidents on the production of 24 February 2005 and by the RF Government decree No. 522 dated 17.08.2007, (On approval of rules for determining the degree of damage caused to human health).
According to the documents, the conclusion about the severity of damage caused by burn injury is done according to the following criteria: danger to life, loss of organ or loss of body function, health disorder, with whom United with a permanent total disability (in %), long-term or short-term health disorder. However, these criteria assess the severity of burn injuries is not applicable in case of burns, do not give a typical picture of a defeat. For example, burns ammonia, acetic acid, caustic and some organic compounds, which, without causing immediately expressed pathological manifestations, subsequently entail major changes in the deeper layers of the skin and underlying tissue and in some cases cause an incorrect assessment of the severity of the damage to health.
Currently, burns, depending on the damage factor vary as thermal, chemical, radiation and electric. The nature of the flow and the degree of damage burns will vary depending on the damaging agent. At the same time, any damaging agent when exposed to the skin causes protein coagulation and, as a consequence, the loss of epithelial cells (necrosis). Under the influence of burns in the body of the victim are a variety of changes, the severity and the severity of which is determined by the size and depth of lesion. The burn area and depth of the lesion is estimated parameters are presented in figure 1.
But today there is no consensus on the phases of the wound healing process. According to modern classification, the tech is the wound healing process is divided into 3 phases. And considering features of the development of the wound healing process are highlighted in clinical podpisi shown in figure 2.
Also today there is no accurate way to determine the area and extent of lesions and organs burns. Aid, with extensive and deep burns, is to cease contact with damaging factor for the prevention of pollution is the imposition of sterile bandages and speedy delivery to a medical facility.
In hospital patients undergo primary treatment of burn wounds with antiseptic solutions (dixital, Miramistin and others), visually determined, depending on the experience of the physician, the area and the degree burn to differentiate methods of treatment of the affected areas, which again depends on the experience of the doctor as methods and means of treatment of burns I and III are different, and special devices that determine the size, extent and depth of lesions burns absent, as there are no devices for first aid, removing the pain and subsequent treatment with a temporary patient monitoring and burn the surface.
There are two basic ways to determine the area of burns: first of them is the method proposed A.Wallace in 1951, known as the "rule of nines". When you do this, take the W the area of each anatomical region in percent is the number that is divisible by 9. The "rule of nines" is applicable to any age (Figure 3). Another common way is the "rule of palm". The results of anthropological research J.Grazer and co-author. (1997) concluded that the area of the palm of an adult is 0.78% of the total surface area of the body. In the process of determining the area of a burn is necessary to correlate the area of the palm of the patient and the physician, in order to avoid systematic measurement error.
The disadvantages of these methods is that the square of burns patients and the degree of burns is determined approximately, with an error of 5-10%. And the depth and extent of a burn is determined with an error of 10-20%. This particularly applies to chemical burns, the depth of which is the 2-3 day. (Bagirov V.L. with soawr. Ointments. The modern view of the medicinal formula. Pharmacy. - 2002. - No. 2, pp.24-26. Modern medical treatment of wounds. Kyiv, 2002. - 39).
Modern methods of treatment of burns involves the choice of drugs depending on the phase of wound currents. Basic requirements for the preparations of the first phase of wound process - cooling wounds, prevention of wound infection, pain, normalization of local hemostasis, adsorption of toxic content wounds, rejection of necrotic at the of Astrov skin and other tissues. In this phase, the widely used hypertension and antiseptic solutions, multi-component hydrophilic ointments on the basis.
In the second and third phases of wound healing drugs should be protected from secondary infection and to provide a cytoprotective effect and the activation of the metabolism, improve blood circulation, stimulate wound healing. In these phases it is recommended to apply products with moderate hyperosmolar effect that they did not cause "osmolarity shock in healthy and nevoobrazimaja epithelial cells. To reduce injury granulation with dressings gauze bandages recommended mesh water repellent hydrophobic coatings containing paraffin, wax, etc. that do not damage the growing epithelium (Compedium 2006. Drugs / edited by V.M. Kovalenko, Appiction. - Kiev: Morion, 2006. - 2270).
The disadvantage of these treatments is that they are time-consuming and outdated. These methods of therapy was used a century ago, changing only the set of drugs, depending on the development of the pharmaceutical industry, but gauze bandages also accompany all the methods of treatment of burns.
The closest method of treatment of burns is laser therapy with the use of helium-neon laser type RIP "Berry"with flux densities of 20-50 mW/cm 2when the exposure 60-120 sec, with a wavelength of 630 nm. The same parameters and have the laser setup type "Pattern-2K, but with wavelengths of 850 and 950 nm.
The disadvantage of this method, as with all lasers is the need to defocus the laser beam for irradiation of burn wounds. All laser equipment is bulky (70-150 kg), requires high energy consumption, short-lived and expensive. For defocusing the laser beam requires the use of additional optical devices, in addition, their use leads to rapid heating of the tissue, which is unacceptable in the treatment of burns.
The objective of the invention is to develop a method for rapid and accurate determination of the area and extent of the lesions of patients with burns, first aid and subsequent treatment through the visible spectrum of light and ultrasound, which allows in a short time, stop pain wounds burns and significantly reduce the time of healing.
The technical result of the invention consists in the rapid and accurate determination of the area and extent of the lesions of patients with burns, to reduce the period during which it is possible to stop the pain of the wound surface burns and significantly reduce the time of healing.
This result is achieved in that the method and system of determining square and St the fines destruction of the patient and first aid for burns, characterized in that by means of white light shoots and transfer to the display screen of the total area of the wound surface burns, with the possibility of increasing the image areas are most affected areas, and by irradiating blue light define the boundaries of the extent of the lesion so that the healthy tissue in the blue spectrum have a pink coloration, areas of the body with the defeat of I and II degrees are from light brown to brown, sections III and IV degrees of lesions range in color from gray-brown to black, necrony scab has a distinct black color.
In addition, using ultrasonic scanner determine the depth of lesion of skin and organs, and optionally display on the monitor in a two-dimensional image of the depth of burn injury and make shots, for a comparative assessment of the dynamics of recovery.
The method of first aid for burns, characterized by the fact that the area of burn injury is sprayed fine aerosol antiseptic funds with fast temperature reduction of the wound surface and the prevention of infectious complications, characterized in that after the application of antiseptic over the wound surface are phototherapy blue spectrum, while air is Noah ventilation.
System for determining the size and extent of injury by burns, first aid and subsequent therapy, including ultrasound scanner with a pulsed supply of the ultrasound emitter/receiver percutaneous, monochromatic blue light emitters, cameras with not less than 5-fold increase, superlight led white light, liquid antiseptic and medicinal products with nozzles, motors that create excessive pressure in the tank, the fan, and the system is designed with the ability to scan the patient by movement of the scanner along the slats installed on the bed or stretcher.
As the ultrasonic system used In the scanner, giving a two-dimensional image of the tissue and organs with a frequency of 0.5-15 MHz.
As monochromatic emitters blue spectrum used emitters with wavelengths of 430-470 nm.
The definition of the area and extent of the lesions of patients with burns are carried out in three successive stages:
1. The surface scan of the patient's body during normal bright white backlight for determining the total area of burns.
2. The surface scan of the patient's body under an intense blue light to determine the extent of damage to the surface of the skin for burns.
3. Ultrasonic ASCS shall adowanie depth of lesions and organs burns III and IV and in chemical burns, with subsequent excretion of the results of the scan on the display screen with the designation of the area affected, boundaries of the extent of the lesion and the view, if necessary, the depth of the defeat of separate areas; processing of fine antiseptic spray with simultaneous cooling of the affected areas, relief of pain due to the simultaneous application of fine aerosols mestnoanesteziruushim funds, intense blue light with a light output of 30-70 mW/cm2and ultrasound to relieve pain shock and improve the health of the patient, followed by processing directional air flow burn the surface. The system, which determines the size and extent of the lesion in case of burns, first aid and subsequent treatment through the visible spectrum of light, ultrasonic waves, including ultrasonic scanner with a pulsed supply of the ultrasound emitter-receiver percutaneous, monochromatic blue light emitters, cameras, not less than 5-fold increase, using superlight led white light tanks for liquid antiseptic and drug injectors, electric motors that create excessive pressure in the tank, fan and system motion when scanning the patient fast for any kind of mattress, including a stretcher.
As the ultrasonic system preferred In the scanner, giving vumerno the image of tissue and organs with a frequency of 0.5-15 MHz.
As monochromatic emitters blue spectrum of the selected emitters with wavelengths of 430-470 nm, with high antibacterial and analgesic action due to sensitization molecules cells provides additional energy for their metabolism.
Apply antiseptic and therapeutic tools in the form of a fine aerosol provide painless their application to a burn wound, lowering the temperature of the wound surface of the means.
Ventilation with dry air allows a reduction of the temperature of the wound surface, painless removal of necrotic tissue and exudates.
Combined application of antiseptic therapeutic ultrasound, monochromatic emitters and ventilation burn surface will enhance the properties of antiseptics, increase membrane permeability and cell okoloigrovoy surface, to reduce the viscosity of therapeutic aerosols and exudate, to increase the activity of the metabolism of body cells and capitalizatio new cells, provides tissue heat transfer with the surrounding environment, preventing a "greenhouse effect" (Aniolami. Fundamentals of medical physics. - Samara: Samara printing house", 2008 - P.77-84; Woolamaloo. Medical Biophysics: a textbook for high schools: St. Petersburg. Specic, 2007 - S-203; Prof. Sbiroli. M the health svedocenje. Moscow: Izd. "New village", 1926 - P.21-98).
The implementation of the invention
The device with the specified functions, moving above the patient, with a bright white light, photographs, records and transmits to the display screen, the total area of the wound surface burns, including numerical ratio in percent, with the possibility of increasing the most affected places, for logging and monitoring the dynamics of therapy wound surface. Under an intense blue light are determined by the boundaries of the extent of the lesion, since healthy tissue in the blue spectrum have a pink coloration, areas of the body with the defeat of I and II degrees are from light brown to brown, sections III and IV degrees of lesions range in color from gray-brown to black, necrony scab has bright black color. Depending on the extent of damage to the expert chooses therapy for each plot. Also the device using ultrasonic scanner is determined by the depth of lesion of skin and organs, and, if necessary, display on the monitor in a two-dimensional image of the depth of burn injury and make images for comparative dynamics of recovery. After determining the size and extent of damage to the device diffuses fine aerosol antiseptic means for quickly reducing the temperature of the wound surface and p is opractice infectious complications. After the application of antiseptic over the wound surface is phototherapy blue range, with simultaneous air ventilation for pain relief, reducing the temperature of the wound surface, restoration of microcirculation and air removal of necrotic tissue. After the necessary surgical intervention (when available water blisters) device is applied in the form of a fine aerosol drug with film-forming suspension, which again leads to a reduction of the temperature of the burn surface and prevents the "greenhouse effect" of the wound. After drug application device includes blue emitters, which range reduces pain, restores circulation, activates the drug and increases the metabolism of the cells, and simultaneous operation of the ultrasonic transmitter increases the permeability of the pores and membranes of skin cells and epithelium for medicines. After air ventilation is activated. The whole process of scanning and first aid takes a few minutes, treatments phototherapy and air ventilation may be repeated depending on the severity of burn injury, several times for 3-5 minutes In the case of the use autodermoplastic or xenoplasty (closing is Rogovoy surface using the skin plasty), apply phototherapy with simultaneous air ventilation for removal of the exudate and fluid from the surface of the burn wounds. The blue spectrum will speed up the healing process of the wound surface and will prevent secondary infection, providing cytoprotective action, will help to boost the metabolism, improve blood supply of tissues at the microcirculation level.
Examples of application of the method.
Example 1. Patient K., 38 years. Dr. C: the Burn of the forearm boiling water 3 h earlier. Strong reddening of the skin from wrist to elbow, swelling, severe pain (burning) of the skin of the forearm.
When examining the patient's arm was installed I burn degree burn area is 3% and the depth of destruction of the epidermis and dermis from 1 to 3 mm for 30 seconds. Photos of the burn of the forearm at the time of documentation at the time of admission in the emergency room. Processing was carried out throughout the surface of the burn fine spray 30% water-alcohol solution (100 ml) for 2 min, followed by phototherapy with blue light 6 min and air ventilation system.
In the period of first aid pain relief began in the 3rd minute from the start of the procedures in Exodus 7 minutes the pain was almost gone, there was a feeling of "pins and needles under the skin temperature of the affected area after 8 min decreased from 39.7°C to 37.4°C.
The village is e phototherapy was applied aerosol "Alisol" (other Ukraine) is a combined aerosol product that contains sea buckthorn oil, chloramphenicol, benzocaine and boric acid. Olazol has analgesic and antimicrobial action, promotes tissue regeneration and accelerates wound healing. The spray was applied within 30 seconds, the entire wound surface.
After application of the drug was carried out ultrasonic treatment of burns and phototherapy for 3 min, followed by air ventilation.
Burn the pain of the wound surface was controlled completely within 15 min after the start of the procedure, delivering only a small concern with heavy use of fingers. Was further carried out for another 5 procedures for application of the drug "Alisol" on the wound surface, light therapy, ultrasound and air treatment within 48 hours. By the end of the second day from the burn was only a small reddening of the skin area of about 1%. Painful symptoms are gone, even when pressing on the wound surface. Further therapy at home is to apply the bepanten ointment (Germany) during the week. The consequences of the burn was expressed only in the skin peeling after 7 days, the visual changes to burn absent.
Example 2. Patient P., 68 years. Burn leg from the hip to the foot of freshly made soup 1.5 hours ago. Severe pain over the entire surface of the zhoga, numerous blisters, severe pain in the chest. Over the past 7 years, the patient suffers from coronary heart disease, two to three times a month there are strokes for 5-8 min, blood viscosity increased. Treatment on an outpatient basis for the adopted standard. Smokes with 42 years of age, alcohol is not used.
After examining the burn the patient's leg was set burn II degree burn area is 4.5% and the depth of destruction of the epidermis and dermis from 1 to 4 mm for 50 sec. Photos of the burn feet at the time of documentation at the time of admission in the emergency room. Processing was carried out throughout the surface of the burn fine aerosol physiological salt solution (100 ml) for 1.5 min, followed by phototherapy with blue light 8 min and air ventilation. After the procedure was done ECG made HELL froze and accepted nitroglycerin.
In the period of first aid coping with the pain began on the 5th minute from the start of the procedures in Exodus 7 minutes, the pain was almost gone, there was a feeling of "pins and needles under the skin temperature of the affected area after 8 min decreased from 39.3°C to 37.5°C, HELL has changed since 180/130 on 155/95.
After phototherapy was applied aerosol drug "Betadine" (Hungary) - antiseptic agent. Due to the inclusion in the composition of the iodine has a wide range of action is via against bacteria, protozoa, fungi and some viruses. Bactericidal effect with a gradual release of iodine from the drug after contact with mucous membranes or skin. The action is in the interaction of iodine with oxidizable groups of amino acids, which form the structural proteins and enzymes of microorganisms which are destroyed or inactivated. The spray was applied within 30 seconds, the entire wound surface.
After drug application was performed phototherapy for 3 min, followed by air ventilation. After pain relief is dissected and removed blisters, wounds treated with saline in the form of an aerosol, followed by the application of phototherapy and air flow for 5 minutes
The surface of the burn is applied in the form of an aerosol drug "Panthenol" (Germany). The drug improves tissue regeneration and is designed for outdoor use. The active drug substance - dexpanthenol - enters Pantothenic acid, which, being a part of coenzyme A, plays an important role in the acetylation and oxidation, is involved in carbohydrate, fat metabolism and in the synthesis of acetylcholine. Has some anti-inflammatory effect. Reduce mechanical irritation of paragen the second skin area. After this procedure, the burn surface is exposed to ultrasound and phototherapy blue spectrum for 5 min, after which the surface is exposed to air flow for 3 minutes
Subsequent procedures were carried out in a day, for 4 days, on day 5, it was found that malpighian layer after removal of the bubbles completely kapitalizirovana, the inflammatory process and pain of the affected areas are missing. By day 15, the patient was able to stand on the injured leg without pain, subsequent therapy was only in the imposition of clean gauze bandages.
With the same diagnosis and equal to the area of damage just with hot water, not fat-containing food with standard therapy, on the amendment, the patient went only 22 days, and to walk the patient was only for 36 hours. Similar examples are described in the Chapter "the Outcomes of the treatment of burn wounds and burn disease" (Taarii. Burns and frostbite. Leningrad, "Medicine", 1971, - s-200).
Thus, we can conclude that the proposed method of determining the size and extent of injury of the patient with burns, first aid and subsequent treatment through the visible spectrum of light, ultrasound system and its implementation will significantly reduce the time to diagnosis and the accuracy of the determination of the area and extent of injury, clearly provide maps is well affected tissues, and minimize the time to first aid and subsequent treatment, which greatly reduces the risk of background diseases, mortality and disability of the person with burns.
The proposed method has the following advantages.
1. The diagnostic methods are tools first aid and subsequent treatment.
2. Through the combined use of phototherapy and drugs, increase therapeutic possibilities of the applied drug that reduces and quantitative application and reduces the risk of negative side effects and cost of treatment.
3. The method allows rapid and accurate determination of the area and extent of injury, and visual dynamics of recovery of the patients.
4. The method can significantly reduce the time of treatment and the risks of deaths from shocks in the first hours after burn injury.
Classification of the area and the depth of the lesion:
|The degree burn||Depth damage||Clinic and morphology||Recommended treatments|
|I||Epidermal burns||Redness, swelling of skin, fine bubbles with content||Treatment with bandages or open method|
|II||Superficial dermal burns||Tense or revealed blisters, exfoliation of the epidermis with the formation of a thin scab||Treatment with bandages or open method. Burns with a large area of the lesion shows the xenoplasty (skin grafts animals).|
|III||Deep dermal burns||Primary formation of a dry scab||Decompressive necrotomy (dissection scab), xenoplasty or autodermoplasty (skin grafts of the patient to close the wound surface)|
|IV||Subfascial burns||The most frequent and dangerous localization of head and limbs. Expressed increasing swelling of the extremities. Self-exclusion osteonecrosis, prolonged healing (up to 3-8 months)||Decompressive surgery in the period of the shock. Necrectomy, transplantation of complex patches of skin in the early stages after injury|
The burn area is assessed as a percentage of total p is oshadi the surface of the body. For adults the surface of the head and neck is equal to 9% of the total body surface, the surface of one of the upper extremity - 9%, the surface of the chest and abdomen - 18%, the rear surface of the trunk - 18%, the surface of one lower extremity is 18%, the surface of prominate and external genitalia - 1%.
1. How to determine the area and extent of the lesion of the patient and subsequent therapy for burns, characterized by the fact that using the system, providing diagnosis and treatment of these patients are shooting at the white backlight of the total area of the wound surface burn and transmit images on the display screen by irradiating blue light define the boundaries of the zones of the lesion and healthy tissue in the blue spectrum are red staining, areas with lesions of the I and II degrees are from light brown to brown, sections III and IV degrees of lesions range in color from gray-brown to black, scab necrony has a distinct black color, then on the area of burn injury is sprayed fine aerosol antiseptic, and then over the entire wound surface are phototherapy blue range, with simultaneous air ventilation.
2. The method according to claim 1, characterized in that it further with the help of an ultrasound scanner to determine the depth of porazeni the skin and organs, and optionally display on the monitor in a two-dimensional image of the depth of burn injury and make images for comparative evaluation of the dynamics of recovery.
3. System for determining the size and extent of injury of the patient and subsequent therapy for the treatment of burns, including ultrasound scanner with a pulsed supply of the ultrasound emitter/receiver percutaneous, monochromatic blue light emitters, cameras with not less than 5-fold increase, superlight led white light, liquid antiseptic and medicinal products with nozzles, motors that create excessive pressure in the tank, the fan, and the system is designed with the ability to scan the patient by movement of the scanner along the slats installed on the bed or stretcher.
4. The system according to claim 3, characterized in that the ultrasonic system used In the scanner, giving a two-dimensional image of the tissue and organs with a frequency of 0.5-15 MHz.
5. The system according to claim 3, characterized in that as a monochromatic emitters blue spectrum emitters used with a wavelength of 430-470 nm.
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to medicine and pharmacy, and represents a pharmaceutical composition possessing venotonic, wound healing, anti-inflammatory action, containing a therapeutically effective amount of sodium heparin in a combination with Troxerutin and Dexpantenol, and as auxiliary substances - propylene glycol, trometamol, preserving agent and purified water, differing by the fact that it additionally contains UV filter Escalol 567, organosilicone elastomer DC 9045, organosilicone emulsifier DC 5329, cyclomethicone DC 345, antioxidant Tinogard NOA, acrylate emulsion of copolymer Salcare SC80, and a preserving agent is Sharomix MCI with the ingredients taken in certain proportions, wt %.
EFFECT: invention provides manifested venotonic, wound healing and anti-inflammatory action with no allergic reactions.
3 ex, 1 tbl
SUBSTANCE: there are produced peptides having one to fourteen residues which represents short fragments of the peptide HB-107 (SEQ ID NO:1) which in itself is a fragment of the antibacterial protein cecropin C and shows cell stimulation, migration and anti-inflammatory properties.
EFFECT: using the produced peptides with respect to keratinocytes being higher sensitive to the given effects, enables treating skin damages, such as diabetic ulcer damages; the peptides are also effective for prevention and relief of the skin surface damages caused by various disturbing environmental factors, in the concentrations equal to or more than the concentration of the peptide HB-107.
14 cl, 3 dwg, 5 tbl, 4 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to an ointment for treating infected wounds in purulo-necrotic wound process. As active substances, the ointment contains furacilin, lidocaine and dibunol, and as an ointment gel base, it contains a styrene maleic anhydride copolymer, Lutrol F-127 and purified water in certain proportions.
EFFECT: ointment is used as an anti-inflammatory, antimicrobial, anaesthetic, regeneration stimulating, antioxidant, antiviral agent with prolongation effect.
3 dwg, 2 tbl, 7 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to chemical-pharmaceutical industry and concerns treating diabetic patients. The wound-healing agents for wound preventing and repair in diabetic patients contains alcohol-water extracts of yellow melilot, laurel, purple Echinacea, and also a solid extract of common licorice, aloe vera juice, taurine and the base PEO-400 and PEO-1500 alloy in the following proportions, wt %: the alcohol-water extract of yellow melilot 2.0-2.5, the alcohol-water extract of laurel 3.0-3.5, the alcohol-water extract of purple Echinacea 1.0-1.5, the solid extract of common licorice 1.0-1.5, aloe vera juice 1.0-1.5, taurine 2.0-2.5, the base - to 100.0.
EFFECT: agent promotes line skin wound healing with underlying experimental alloxan diabetes at all three stages of the wound process (exudation, proliferation, epithelisation).
1 ex, 3 tbl, 3 dwg
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to medicine and concerns preventing and treating the complication of diabetes - diabetic foot infections (DFIs). A wound-healing agent for wound prevention and repair in the diabetic patients contains an alcoholic-aqueous extract of St. John's wort, sea-buckthorn oil, propolis infusion and as a base, PEO-400 and PEO-1500 alloy (1:1) in the following proportions, wt %: the alcoholic-aqueous extract of St. John's wort 5.0; sea-buckthorn oil 3.0; propolis infusion 2.0; the base - the rest.
EFFECT: agent promotes line skin wound healing with underlying experimental alloxan diabetes at all three stages of the wound process (exudation, proliferation, epithelisation).
SUBSTANCE: invention relates to medicine, namely to combustiology, and can be used for treatment of infected burn wounds of IIIA degree. For this purpose on wound surface cleaned from damaged tissues and serous-purulent discharge, for 2-4 days applied is bandage representing construction from organosilicon polymer, covered with type I human collagen with platelet growth factor -PDGF-BB and pectin, for obtaining which collagen in form of thin layer of collagen sponge about 1-1.5 mm, obtained by method of lyophilisation of 1-2% collagen solution on perforated substrate from polysiloxane-polycarbonate film, is moistened with 2% solution of apple pectin with realisation of re-lyophilisation.
EFFECT: method makes it possible to increase treatment efficiency due to reduction of quantity and species diversity of microflora without influencing activity of proliferation process with simultaneous acceleration of wound healing.
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention relates to chemical-pharmaceutical industry and deals with preparation for wet wound healing and prevention of bandage adhesion to wound, containing pharmacologically acceptable chitosan-glucan complex or its salt, in combination with one or more other polysaccharide or their respective salts, and antiseptic, with chitosan-glucan complex possessing viscosity 2.5 Pa·s-30 Pa·s with solution concentration 2.5% at 25 єC and angular rate of rotation 0.0314 rad/sec, and concentration of glucosamine within from 0.05 (n/n) to 20 (n/n). Preparation contains from 0.01 to 100% by weight of chitosan-glucan complex, from 0 to 99% by weight of another polysaccharide and from 0 to 50% by weight of antiseptic.
EFFECT: according to the invention, in application, preparation indirectly supports process of wound healing and drains excessive secretion together with tissue mediators and enzymes which support healing, thus ensuring necessary hydration of wound and tissues that surround it without softening surrounding skin or drying and adhesion to wound; addition of antiseptic prevents further infection.
15 cl, 6 ex, 1 tbl
SUBSTANCE: invention refers to medicine, and concerns a method of increasing body repair activity consisting in management of a wound with a wound healing formulation containing peptides used in a medicinal base. The peptides are presented by the peptides having the following structure LYS GLY PRO LEY THR NLE NLE ALA SER HIS TYR LYS GLN HIS CYS PRO and THR NLE NLE ALA SER HIS TYR LYS GLN HIS CYS PRO.
EFFECT: invention provides increasing repair activity in the relation to the wound process.
1 cl, 7 dwg
SUBSTANCE: invention refers to medicine and cosmetology, and represents a method for preparing a herbal water-soluble polysaccharide agent for skin defect elimination and wound repair involving mixing and constant stirring water and water-soluble cellulose derivative and at least one water-soluble polysaccharide containing anion groups and forming polyanions in the solution, sterilising the prepared mixture, differing by the fact that the prepared mixture is heated to temperature 90°C-115°C and then cooled to temperature max. 12°C with a heating-cooling cycle repeated at least twice.
EFFECT: invention enables preparing a transparent gel that is ensured by improving its smoothness, and also increasing its resistance to delamination.
9 cl, 7 ex, 4 dwg
SUBSTANCE: invention refers to cosmetology and dermatology, and represents a method for preparing a local skin composition, involving: making fish roe available; and preparing a recovered water-soluble fraction of said fish roe differing by the fact that it contains messenger RNA and protein in the amount of 100 to 380 mg/ml where said fraction is prepared by destruction of said fish roe and decontamination by centrifugation of said lysed fish roe; and introducing said recovered water-soluble fraction of said fish roe into the composition of a cream, a gel, a spray, an emulsion, a solid, plastic material or a matrix, an ointment, a powder or a lotion for local application.
EFFECT: invention provides improved cosmetic appearance, activation, improvement or recovery of cells and tissues, preferentially skin, and more preferentially for recovery of aged or injured skin.
8 cl, 12 ex, 9 tbl, 4 dwg
SUBSTANCE: invention refers to physiotherapeutic apparatuses. A presented apparatus comprises a handle body which integrates a power supply unit and a control unit, a laser diode coupled with the control unit with emission brought outside through an outlet on a pointed handle tip. A side surface of the handle comprises a general electrode also connected with the control unit. The control unit is connected to the power supply unit. On an internal side surface of the outlet, there is an acupuncture point detector represented by a thin metal core of the diameter no more than 1 mm as specified by the acupuncture point size, one end of which is bent so that it gets into a laser beam, and another one is connected to the control unit.
EFFECT: ensured both acupuncture point detection and exposure to low-intensity laser radiation that are combined with silver ion microelectrophoresis by the same apparatus.
SUBSTANCE: invention relates to medicine, namely to ophthalmology and is intended for slowing down rough scarring of conjunctiva in carrying out photodynamic therapy in conditions of vascular proliferation of conjunctiva. First, not less than 2 mg of alasense are introduced subconjunctivally. After 1.5-2 hours impact with laser radiation with wavelength 632.8 nm, power density 47.7-55.7 mW/cm2, is performed for 10-14 minutes. 12-24 hours after intervention medication viscleron is introduced into conjunctival sac of affected eye 1 drop 3 times per day, during not fewer than 10 days.
EFFECT: method ensures efficient suppression of angiogenesis of conjunctiva vessels in zones of proliferating cells due to application of aggressive parameters of laser impact with simultaneous prevention of necrobiotic and destructive changes due to protective effect on irradiated tissues.
SUBSTANCE: invention refers to medicine and can be applied for treating ischemic ulcers of lower extremities. For this purpose, patient's blood is exposed to intravascular optical quasi-monochromatic blue light at wave length 450±20 nm and output light intensity 1.5 mWt. It is combined with the regional antibacterial therapy with using photodynamic therapy. That is ensured by coating the ulcer surface with a photosensitiser in the form of a biosoluble gel for 30-40 minutes to be removed while the ulcer surface is exposed to blue light at wave length 450±20 nm, power density 0.25 Wt/cm2, energy flux density 10 J/cm2.
EFFECT: method enables covering the blood rheology, improves blood flow in the lower extremity vessels, provides a reliable bacteriostatic effect and successful stimulation of reparative processes.
6 cl, 3 ex
SUBSTANCE: invention refers to medicine, namely ophthalmology, physiotherapy. The method involves the exposure on an infraorbital region and surrounding regions. The exposure is ensured by pulse light, continuous emission and magnetic field. Wave length of the pulse light is 800-1200 nm, and wave length of the continuous emission is 630-670 nm. Average power of the pulse light is 3.0-10.0 mWt; pulse power is 2.0-4.0 Wt and pulse repetition frequency is 5.0 Hz - 10.0 kHz. Average power of the continuous emission is 50.0 Wt. Magnetic field strength is 20-45 mT. Said exposures are alternative or simultaneous. Supraorbital ridges, temporal and infraorbital regions are exposed. The exposure length is 1.0-5.0 minutes. Each session is preceded by instillation of trophic drops. The therapeutic course includes 7-15 sessions.
EFFECT: method prolongs the remission period ensured by cyliary spasmolysis.
2 cl, 3 ex
SUBSTANCE: invention refers to medicine, namely physiotherapy, and may be used for laserophoresis of biologically active substances of higher molecular weight. What is used is a low-intensity laser emission (LILE) by alternating various wave lengths and power densities every second day. At wave length 632-638 nm, power density makes 10-40 mWt/cm2. At wave length 780-785 nm, power density makes 20-90 mWt/cm2. Length of the exposure on one area makes 0.5-1 minute. Length of one session does not exceed 15 minutes.
EFFECT: implementing the method provides higher volumes of the substance of higher molecular weight introduced by laserophoresis in treating various dermatological diseases and eliminating cosmetic defects ensure by more optimal distribution of the introduced substance in biotissues.
3 cl, 3 dwg
SUBSTANCE: invention refers to medicine and may be used in neurology, traumatology, physiotherapy, orthopaedics, in stepped therapy of protrusions, herniated disks, scoliosis, kyphosis, kyphoscoliosis, spondylolisthesis, osteochondrosis, myofascial syndrome, myositis, vertebrogenic (discogenic) torticollis, intercostal neuralgia, lumbago, lumbar ischialgia. The I stage consists in intravenous blood exposure to UV and red low-intensity laser emission, graduated uniform extension of all spinal segments in a traction apparatus with no fixation devices with considering patient's anthropometric data in complete muscular relaxation. The stage II consists of two alternating series of procedures. The series I implies paravertebral vacuum cup massage from both side upwards from a lumbar to cervical spine along massage lines of the back with a cup tightly pressed to skin. It is followed with vacuum gradient therapy with using a number of cups of different volumes and sections simultaneously along a venous outflow. Further, a leech therapy (LT) covering an umbilicus, a swing therapy (ST) in the SWING MACHINE training facility. The series II includes a one-day acupress therapy of the spinal muscular frame with using ebonite rollers along massage lines of the back, then - manual exposure on its musculo-ligamentous apparatus and joints in the form of various massage types, a yumeiho therapy, a postisometric relaxation, further the LT and the ST on the back area. The days free from the manual exposure and the LT on the back area; the ST is followed by physical exercises based on the system of traditional Cigun, Nishi, yoga techniques The stage III provides diagnosis and orthopaedic feet correction.
EFFECT: therapeutic effect is ensured by exposure on all the pathogenesis patterns of the spinal diseases: cell, immune, humoral, neuromuscular, mechanical, reflex, at the level of the integrated system, including principal drug-free recovery of the spinal health.
6 cl, 5 dwg, 5 ex
SUBSTANCE: invention refers to medicine, dentistry, and is applicable for preventing and treating dental diseases of teeth and oral cavity. For this purpose, a surface of gums and teeth is exposed to an optical range, and the exposure is combined with tooth brushing with using a tooth paste. The tooth brushing is combined with exposure of the oral mucosa opposite to the teeth. The tooth paste is presented by a tooth paste with a photosensitiser. Wave length of the emission directed to the teeth is specified to be close to the wave length of photosensitiser excitation. Wave length of the emission directed towards the oral mucosa opposite to the teeth is specified in a short-wave optical spectrum.
EFFECT: method provides improved antimicrobial, anti-inflammatory, anti-caries action ensured by stimulation of cell restoration processes, improvement of local tissue circulation and nutrition, relieved oral irritation and inflammation.
5 cl, 1 dwg
SUBSTANCE: invention refers to medicine, specifically to sports medicine. A method involves a colour-pulse exposure. The exposure is performed in a red visible spectrum, at wave length 630 nm and frequency 40 Hz. Each eye is alternately exposed for 5 minutes. The sessions are daily; the therapeutic course is 10 procedures.
EFFECT: method provides higher adaptation effect ensured by optimising vegetative regulation, sensory visual system and body microcirculation.
2 tbl, 1 ex
SUBSTANCE: invention relates to medicine, oncology and radiology and consists in carrying out complex treatment by installation of endobronchial reverse valve into bleeding bronchus. At this background performed is external beam radiotherapy (EBRT) TFD 40 Gy, with radiomodifier: 5 fluorouracil - 250 mg, course dose - 4-5 g, or cysplatin - 10 mg, course dose - 120 mg, which are introduced daily, intravenously 30 minutes before the beginning of EBRT session. 14 days after completion of the first stage of EBRT fibrobronchoscopy (FBS) is performed with removal of bronchoblocker, and the second stage of EBRT TFD 30 Gy is performed to total dose for two stages EBRT TFD 70 Gy, with application of the same radiomodifiers in the same mode. 30 days after finishing EBRT FBS is made and is tumour remains in bronchus lumen or there is a suspicion of it, photodynamic preparation is introduced intravenously, and after 4 hours FBS and laser irradiation of tumour are carried out. Control examination of tracheobroncial tree is carried out after 30 days and after 26 months.
EFFECT: method ensures increase of life expectancy and improvement of its quality for patients with non-operable lung cancer complicated by hemorrhage.
SUBSTANCE: invention concerns medicine, oncology, and is applicable for photodynamic therapy of malignant growths. That is ensured by photodynamic therapy. For this purpose, a photosensitiser is introduced in suppositories through rectum. The photosensitiser is presented by mixed chlorine derivatives and spirulina platensis with added excipient for suppositories. The suppository ingredients are taken in the following proportions, wt %: chlorine derivatives -0.1-0.4; spirulina platensis -3-4.5; excipient - 95.1-96.9. The new grown is exposed to light at wave length corresponding to a maximum absorption of chlorine derivatives.
EFFECT: method enables higher clinical effectiveness, eliminated disadvantage of the invasive introduction.
7 cl; 2 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention relates to aerosol composition, suitable for application for treatment of bronchospasms and associated with them disorders, which contains therapeutically efficient amount of troventol, microground together with propellant and one or more pharmaceutically acceptable carrier. Composition preferably contains 40-640 mcg of troventol and carrier can be selected from surface-active substance, co-solvent, antioxidant and/or filling agent.
EFFECT: invention also relates to dosing inhalator which contains aerosol composition for treatment of bronchospasms and associated with them disorders.
22 cl, 6 tbl, 2 ex