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Agent showing hepatoprotective action, and method for preparing it. RU patent 2462259. |
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FIELD: medicine, pharmaceutics. SUBSTANCE: invention refers to pharmaceutical industry, specifically to an agent showing hepatoprotective action. The agent showing hepatoprotective action of a herbal polyphenol extract of Amur maackia heartwood (Maxar) which represents an aqueous solution of Maxar in the molecular-capsulated form in the form of a water-soluble associated with a surfactant having a specific hydrophilic-lipophilic balance. A method for preparing the agent showing hepatoprotective action by Maxar homogenisation in the melt surfactant under certain conditions to produce the molecular-capsulated form of the end product. EFFECT: agent shows higher biological accessibility and hepatoprotective activity ratio. 10 cl, 2 dwg, 1 tbl, 1 ex
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Method of treating patients with chronic liver diseases in stage of latency and degree i manifested stage of hepatic encephalopathy / 2462251 Invention refers to medicine and aims at treating the patients with chronic liver diseases (CLD) in the stage of latency and degree I manifested stage of hepatic encephalopathy. The preparation Essentiale forte N is used. It is combined with prescribing the preparation Mucofalk. The course is 28-30 days. |
Method of treating chronic viral hepatitis c / 2459629 Invention refers to medicine, namely hepatology and may be applicable in treating chronic viral hepatitis C. That is ensured by introducing short-lived interferon-alpha (IFN) and the nucleoside analogue Ribamidil in the patient with an initial average week dosage specified in the range of 10.5 to 21.0 mil. IU depending on the level of native patient's interferon-alpha. Interferon-alpha is introduced with at least twice gradually increase of the average week dose to 21.0 to 84 mil. IU. Over the whole period of introducing IFN, the patient is prescribed with additional antiviral preparations - an interferon inducer, as well as an amantadin preparation or a glycyrrhizic acid preparation. It is combined with a support therapy involving the introduction of T-cell immunity stimulators and preparations for correction of side effects. The presence of blood viral ribonucleic acid is occasionally controlled and the introduction of Ribamidil is started in a daily dose of 800-1200 mg from the third month from the beginning of treatment if observing the presence of ribonucleic acid or from the tenth month if observing the absence. The treatment is continued until at least a 12-month aviremia period is achieved. |
Method of prevention and treatment of liver disease with application of receptor a2b antagonists / 2457842 Group of inventions relates to field of medicine. Method of treatment and prevention of liver fibrosis includes peroral introduction to mammal of therapeutically efficient amount of antagonist of adenosine receptor A2B - 3-ethyl-1-propyl-8-(1-{[3-(trifluormethyl)phenyl]methyl}pyrazol-4-yl)-1,3,7-trihydropurine-2,6-dione. Method of reducing hepatotoxic side effects of chemical therapy or radiotherapy includes peroral introduction to mammal who underwent such treatment of therapeutically efficient amount of antagonist of adenosine receptor A2B - 3-ethyl-1-propyl-8-(1-{[3-(trifluormethyl)phenyl]methyl}pyrazol-4-yl) -1,3,7-trihydropurine-2,6-dione. |
Granule and method for making thereof / 2456980 Invention refers to pharmaceutics. A pharmaceutical granule is spherical or spheroidal and has volume density 0.6-1.3 g/ml and disintegration 0.5-5 minutes. Active pharmaceutical ingredients are preparations of Traditional Chinese Medicine, herbal preparations or their extracts with a nucleus made of an extract of Traditional Chinese Medicine or herbal preparations, and a pharmaceutically acceptable carrier. The content of the pharmaceutically acceptable carrier with respect to total granule weight makes 10-60 wt %. The granule diameter can be equal to 700-1500 mcm. The granule nucleus diameter can be equal to 200-750 mcm. The granule can be also coated with a layer of 2-5 wt % with respect of total granule weight. A method for making the granules consists in introducing initial granules into a layer of a fluidised material as an excipient; the active pharmaceutical ingredients are prepared in the form of a suspension or a solution of the viscosity controlled within 6.0-9.8 MPa·s with using a viscosity-control agent; then they are sprayed over a surface of the initial granule for making a finished granule. |
Method for preventing and treating hepatic consequences of ischemia / 2456678 Liver is resected in an animal experimentally. A pharmacological protection is presented by Mexicor and Serotonine Adipinate. On the operation day, 5% Mexicor is used in the form of intravenous slow stream introductions twice - 35 minutes before the operation in a dose of 5 mg/kg of weight and 11 hours after the first introduction in a dose of 7 mg/kg of weight. Serotonine Adipinate dissolved in 5 ml of isotonic solution NaCl is used in the form of intravenous slow stream introductions three times - 1 hour before the operation in a dose of 0.15 mg/kg of weight, 2 hours after the first introduction in a dose of 0.2 mg/kg of weight, 10 hours after the first introduction in a dose of 0.1 mg/kg of weight. During the postoperative period, Mexicor and Serotonine Adipinate are introduced for 8 days. Mexicor is introduced three times a day at 9 o'clock in a dose of 2.5 mg/kg of weight, at 15 o'clock in a dose of 1.5 mg/kg of weight, at 21 o'clock in a dose of 6 mg/kg of weight. Serotonine Adipinate is introduced twice a day - at 8 o'clock in a dose of 0.15 mg/kg of weight, at 17 o'clock in a dose of 0.1 mg/kg of weight. |
Benzimidazole derivatives, based pharmaceutical composition and methods of using them / 2456276 Present invention refers to new benzimidazole derivatives of general formula (I) or to its pharmacologically acceptable salts wherein R1 represents a C6-aryl group which can be substituted by 1-3 groups optionally specified in a group of substitutes (a), or a heterocyclic group which represents pyridyl, dihydrobenzofuranyl, 1,3-benzodioxolyl, tetrahydropyranyl, tetrahydrofuranyl which can be substituted by 1-3 groups optionally specified in a group of substitutes (a), R2 represents a C1-C6 alkyl group, R3 represents a C6-aryl group which can be substituted by 1-2 groups optionally specified in a group of substitutes (a), Q represents a group represented by formula =CH-, or a nitrogen atom and a group of substitutes (a) represents a group consisting of a halogen atom, a C1-C6 alkyl group, a C1-C6 halogenated alkyl group, a carboxyl group, a C2-C7 alkylcarbonyl group, a C2-C7 alkoxycarbonyl group, a C1-C6 alkoxy group, a C1-C6 halogenated alkoxy group, an amino group, a 4-morpholinyl group and a di-C1-C6 alkyl)amino group. Also, the invention refers to a pharmaceutical composition based on a compound of formula (I), to a PPARγ activator/modulator based on the compound of formula (I), to using the compound of formula (I), to a method of reducing blood glucose, to a method of activating PPARγ, a method of treating and/or preventing said pathological conditions. |
Method of preventing liver injury in formation of syndrome of combined dystrophic-degenerative changes of mesenchimal derivatives in case of local chronic inflammatory process and means for its realisation / 2455988 Claimed is means for prevention (prophylaxis) of liver injury in formation of syndrome of combined dystrophic-degenerative changes of mesenchimal derivatives in case of local chronic inflammatory process, located outside the liver (CDDCMD in case of LCIP located outside the liver), which represents hormone of pineal gland - melatonin and corresponding method of prevention (prophylaxis) of liver injury in formation of CDDCMD in case of LCIP. |
Method of treating dyskinesia of gallbladder at background of chronic psycho-emotional stress / 2455970 Invention relates to medicine, namely to physiotherapy, gastroenterology. Method includes introduction of diet No5, internal intake of mineral water with the following carrying out transverse galvanisation of epigastrium area, general coniferous baths and impact with physical factor. As physical factor used is electromagnetic radiation of extremely high frequency (EHF). Impact is performed by broad-band noise emitter with frequency 40-63 GHz. Impact is performed on 3 and 4 projection zones in area of the right hypochondrium and on the area of sternum. Impact is performed daily, 10 minutes on each zone. Course includes 10-12 procedures. |
Method for stimulating liver regeneration in fibrotic changes in experiment / 2455701 Under the conditions of modelling cirrhosis in experiment, the preparation EMBRYOBLASTE is introduced in liver tissue by means of an injector needle at the depth up to 0.1 cm. The preparation is introduced along a front surface of the liver, 2 injections in each lobe of the liver to form a papula. The volume of one injection makes 0.3 ml. |
Use of xanthohumol and isoxanthohumol as active substance for preventing and/or controlling liver diseases / 2454996 Group of inventions refers to medicine and aims at preventing and treating a liver diseases. What is used is xanthohumol of formula (I) or xanthohumol metabolite as an active substance for making a preparation for preventing and/or controlling the liver diseases caused by obesity and/or diabetes. The daily dose varies within 0.01 to 161 mg/kg of weight. The xanthohumol content in the composition makes 0.1 to 99 wt %. |
Method of skin and soft tissue wound and wound infection healing / 2462258 Invention refers to medicine, namely surgery, and concerns skin and soft tissue wound and wound infection healing. That is ensured by using tissue coatings impregnated by a phytotherapeutic substrate in the following proportions: eucalyptus leave extract - 30.0 gram; pot marigold blossom extract - 10.0 gram; purple Echinacea herb extract - 10.0 gram; distilled water to 1000.0 ml. |
Method of skin and soft tissue wound and wound infection healing / 2462258 Invention refers to medicine, namely surgery, and concerns skin and soft tissue wound and wound infection healing. That is ensured by using tissue coatings impregnated by a phytotherapeutic substrate in the following proportions: eucalyptus leave extract - 30.0 gram; pot marigold blossom extract - 10.0 gram; purple Echinacea herb extract - 10.0 gram; distilled water to 1000.0 ml. |
Phytomineral composition for immunity reinforcement in poultry in poultry industry and method for using it / 2462257 Invention refers to veterinary science and poultry production. A phytomineral composition is characterised by preparing a solution of 3-4 g of sea salt in 1000 ml of purified water. The solution is heated to temperature 80-90°C, added with dried and ground everlasting, marigold, nettle, birch buds, pine buds, yarrow, laminaria in the following proportions in the solutions, g: everlasting 8-10, marigold 8-10, nettle 8-10, birch buds 8-10, pine buds 8-10, yarrow 8-10, laminaria 8-10, sea salt 3-4. The mixture is soaked in boiling-water bath and kept heated for 1-1.5 hours, cooled, squeezed out, filtered. During autumn, spring and winter, the mixture is added with Saint-John's-wort in the amount of 3-4 g. A method for using the phytomineral composition is characterised by processing a premise by the phytomineral composition in the form of fog spray small dispersion at approximately 1-1.5 ml per m3 and exposing for 5-10 minutes if counting from the spraying termination time. |
Phytomineral composition for immunity reinforcement in poultry in poultry industry and method for using it / 2462257 Invention refers to veterinary science and poultry production. A phytomineral composition is characterised by preparing a solution of 3-4 g of sea salt in 1000 ml of purified water. The solution is heated to temperature 80-90°C, added with dried and ground everlasting, marigold, nettle, birch buds, pine buds, yarrow, laminaria in the following proportions in the solutions, g: everlasting 8-10, marigold 8-10, nettle 8-10, birch buds 8-10, pine buds 8-10, yarrow 8-10, laminaria 8-10, sea salt 3-4. The mixture is soaked in boiling-water bath and kept heated for 1-1.5 hours, cooled, squeezed out, filtered. During autumn, spring and winter, the mixture is added with Saint-John's-wort in the amount of 3-4 g. A method for using the phytomineral composition is characterised by processing a premise by the phytomineral composition in the form of fog spray small dispersion at approximately 1-1.5 ml per m3 and exposing for 5-10 minutes if counting from the spraying termination time. |
Phytomineral composition for immunity reinforcement in poultry in poultry industry and method for using it / 2462257 Invention refers to veterinary science and poultry production. A phytomineral composition is characterised by preparing a solution of 3-4 g of sea salt in 1000 ml of purified water. The solution is heated to temperature 80-90°C, added with dried and ground everlasting, marigold, nettle, birch buds, pine buds, yarrow, laminaria in the following proportions in the solutions, g: everlasting 8-10, marigold 8-10, nettle 8-10, birch buds 8-10, pine buds 8-10, yarrow 8-10, laminaria 8-10, sea salt 3-4. The mixture is soaked in boiling-water bath and kept heated for 1-1.5 hours, cooled, squeezed out, filtered. During autumn, spring and winter, the mixture is added with Saint-John's-wort in the amount of 3-4 g. A method for using the phytomineral composition is characterised by processing a premise by the phytomineral composition in the form of fog spray small dispersion at approximately 1-1.5 ml per m3 and exposing for 5-10 minutes if counting from the spraying termination time. |
Phytomineral composition for immunity reinforcement in poultry in poultry industry and method for using it / 2462257 Invention refers to veterinary science and poultry production. A phytomineral composition is characterised by preparing a solution of 3-4 g of sea salt in 1000 ml of purified water. The solution is heated to temperature 80-90°C, added with dried and ground everlasting, marigold, nettle, birch buds, pine buds, yarrow, laminaria in the following proportions in the solutions, g: everlasting 8-10, marigold 8-10, nettle 8-10, birch buds 8-10, pine buds 8-10, yarrow 8-10, laminaria 8-10, sea salt 3-4. The mixture is soaked in boiling-water bath and kept heated for 1-1.5 hours, cooled, squeezed out, filtered. During autumn, spring and winter, the mixture is added with Saint-John's-wort in the amount of 3-4 g. A method for using the phytomineral composition is characterised by processing a premise by the phytomineral composition in the form of fog spray small dispersion at approximately 1-1.5 ml per m3 and exposing for 5-10 minutes if counting from the spraying termination time. |
Phytomineral composition for immunity reinforcement in poultry in poultry industry and method for using it / 2462257 Invention refers to veterinary science and poultry production. A phytomineral composition is characterised by preparing a solution of 3-4 g of sea salt in 1000 ml of purified water. The solution is heated to temperature 80-90°C, added with dried and ground everlasting, marigold, nettle, birch buds, pine buds, yarrow, laminaria in the following proportions in the solutions, g: everlasting 8-10, marigold 8-10, nettle 8-10, birch buds 8-10, pine buds 8-10, yarrow 8-10, laminaria 8-10, sea salt 3-4. The mixture is soaked in boiling-water bath and kept heated for 1-1.5 hours, cooled, squeezed out, filtered. During autumn, spring and winter, the mixture is added with Saint-John's-wort in the amount of 3-4 g. A method for using the phytomineral composition is characterised by processing a premise by the phytomineral composition in the form of fog spray small dispersion at approximately 1-1.5 ml per m3 and exposing for 5-10 minutes if counting from the spraying termination time. |
Method of treating patients with chronic liver diseases in stage of latency and degree i manifested stage of hepatic encephalopathy / 2462251 Invention refers to medicine and aims at treating the patients with chronic liver diseases (CLD) in the stage of latency and degree I manifested stage of hepatic encephalopathy. The preparation Essentiale forte N is used. It is combined with prescribing the preparation Mucofalk. The course is 28-30 days. |
Therapeutic and prophylactic toothpaste / 2462231 Invention relates to creation of toothpaste for treatment of diseases of oral cavity mucosa and inflammatory diseases of periodontium tissues. Therapeutic and prophylactic toothpaste for treatment of inflammatory diseases of periodontium and oral cavity mucosa contains peptides associated with phospholipids, obtained from liver of Gadidae family with quantitative ratio, wt %: peptides 40-99 and phospholipids 1-60, as well as abrasive material, shape-forming thickening agent, water-retaining substance, cleaning and foam-generating component, preservative, dye, flavour and purified water in specified component ratio. Therapeutic and prophylactic toothpaste can additionally contain antioxidant, sweetener, plant extract, fluorides and/or desensitising agent. Application of toothpaste in short terms results in considerable improvement of state of periodontium and oral cavity tissues. In particular, fast elimination of inflammatory process, reduction of bleeding and painfulness of gums are observed. |
Two-component composition for hair dyeing / 2462230 Invention relates to cosmetic industry and represents product for hair dyeing, which includes first component, including alkaline agent, second component, including hydrogen peroxide and foam-generating container of non-aerosol type for releasing solution of first and second component mixture in form of foam, where mixture solution includes the following ingredients (A) and (B): (A) from 0.1 to 10% by mass of non-ionic surface-active substance and (B) from 0.1 to 5% by mass of cation surface-active substance and mass ratio of ingredient (A) to ingredient (B) (content of ingredient (A)/content of ingredient (B) constitutes from 1 to 100. |
Amino acid preparation eliciting antitumor effect and method for its preparing / 2245143 Invention relates, in particular, to the development of an antitumor preparation based on natural substances. Invention relates to an amino acid preparation comprising at least one modified essential amino acid obtained by treatment of amino acid by ultraviolet radiation (UV) at wavelength 250-350 nm for 12-80 h at temperature 15-30oC or with ozone at temperature 15-25oC. The modified amino acid has no toxicity for health cells. Also, invention relates to a method for preparing such preparation. Invention provides the development of an antitumor preparation based on modified amino acids and expanded assortment of antitumor preparations being without cytotoxicity for normal cells. |
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