Amphiphilic polymer compositions and use thereof

FIELD: chemistry.

SUBSTANCE: invention relates to an amphiphilic polymer composition used in compositions of active substances used for protecting plants from pathogens, phytopathogens or wood destroying fungi, insects etc, or in compositions of additives to food products. The given composition is obtained by reacting (i) at least one hydrophobic polymer P1, which is made from ethylene unsaturated monomers M1, and (ii) at least one hydrophilic polymer P2, which is in form of aliphatic polyethers consisting of at least 50 wt % ethylene oxide groups, with (iii) at least one compound V containing isocyanate groups, which has functionality of 1.5-4.5 relative the isocyanate groups, and is selected from aliphatic, cycloaliphatic and aromatic di- and polyisocyanates, as well as from isocyanurates, allophanates, uretdiones and biurets. Ethylene unsaturated monomers M1 contain: (a1) from 50 to 99 wt % in terms of total amount of monomers M1, monomers M1a of general formula I and a2) from 1 to 50 wt % in terms of total amount of monomers M1, neutral monoethylene unsaturated monomers M1b, which differ from monomers M1a, and are selected from vinylaromatic monomers, C₁₁-C₂₀alkylacrylates and C₁₁-C₂₀alkylmethacrylates.

EFFECT: amphiphilic polymer composition promotes efficient solubilisation and stabilisation of water-insoluble active substances, which leads to increase in stability of such compositions of active substances with respect to demulsification processes during prolonged storage, during addition of an electrolyte and during dilution with water.

25 cl, 9 ex, 2 tbl

The present invention relates to amphiphilic polymer compositions, method of production thereof and to their use for obtaining aqueous compositions of water-insoluble active substances, in particular of active substances for plant protection.

Active substances, i.e. substances that in small concentrations can develop physiological effect, often prepared in the form of aqueous formulations of the compositions. So and prepared to pass, for example, in the field of plant protection products used for pest control active substances, i.e. insecticides, fungicides and herbicides, but also the growth regulators, often as aqueous concentrates, which before use are diluted by supplementation of large amounts of water to the desired concentration for use (so-called "solutions for spraying"). Water composition of active substances showed himself also to pharmaceutically and cosmetically active agents and additives to food products, such as vitamins, provitamins, etc. The same is valid for compositions effector substances, i.e. low molecular weight compounds that are already in small quantities applied are certain technical effect, such as colorants and UV stabilizers.

A fundamental problem with the is-breaking compositions of active substances is typically, in low water solubility of active substances, which often is less than 10 g/l at 23°C/1013 mbar. Aqueous compositions such active substances are therefore heterogeneous systems, and the active substance has as emulsified, respectively, the dispersed phase in a continuous aqueous phase. To stabilize these metastable systems are typically used emulsifiers or dispersing agents. Their stabilizing effect, however, is often poor, so often can cause the precipitation of the active substance, such as settling or sedimentation of the active substance, particularly if the water composition was stored for a long time at an elevated temperature at or near the freezing point. This problem is especially pronounced when the active substance is prone to crystallization.

Often used also and organic solvents to obtain the aqueous compositions of water-insoluble active substances. So, for example, is often used mixed with water, the solvents as an intermediary solubility, i.e. to increase the solubility of the current, respectively, effector substances in the aqueous phase. Not miscible with water, the solvents are used to transfer solid at the temperature existing in the society in the liquid phase, which then can be easier to emulsify. In contrast to suspensions of solid active substance in the emulsions of the active substance molecular dissolved in droplets of solvent and therefore, when applying the best available and therefore more efficiently. Application of larger amounts of solvent is not desirable due to the known problems of labor hygiene, environmental aspects, and partly also of Toxicological considerations.

Another disadvantage of the known aqueous compositions of active substances is relatively large particle size suspended, respectively, emulsified in the aqueous phase particles of the active substance, respectively, of the droplets of the active substance, which usually amounts to a few micrometers. Desirable, however, aqueous compositions in which the active substance has in finely distributed form, so that on the one hand to ensure even distribution of the composition and that the best possible treatment and at the same time, to increase the possibility of biosolvent active substance in the composition. Desirable at this composition, which contains the active substance phase has an average particle size below 500 nm and in particular less than 300 nm. In some cases, it was suggested that the use of the amphiphilic blockcopolymer the s to solubilize water-insoluble active substances in an aqueous diluent. The concept of "solubilisation" denotes achieved through the use of imparting solubility of substances (excipients) uniformly stable distribution of water-soluble acting, respectively, effector substances in the aqueous phase, and the particles of the dispersed phase of the active substance is often so small that they barely scatter visible light and therefore appear to be more or less transparent. Amphiphilic blockcopolymer are, as a rule, at least one hydrophilic polymer block and at least one hydrophobic polymer block.

For example, the document US 2003/0009004 offers for this purpose amphiphilic block copolymers that include a hydrophilic polyethylene block and one hydrophobic block of the biodegradable aliphatic polyester. The drawback to this is that it requires a relatively large amount of polymer, in terms of the active substance, to obtain a stable composition of active substances.

The document US 2003/0157170 describes not water-containing composition of active substances that have one amphiphilic diplokaryon with complex polyester as the hydrophobic part and one additive. The composition formed upon dilution with water containing active substances micelles. The disadvantage here is t is, that requires a relatively large amount of polymer in terms of the active substance.

Document WO 02/82900 describes the use of amphiphilic blossomspietro to obtain aqueous suspensions of water-insoluble active substances of plant protection. Applied copolymers can be obtained by "living", respectively, "controlled" radical blockcopolymers ethanobotany monomers. Along with the fact that these methods are relatively complex, aqueous composition of active substances contain a large amount of water-soluble organic solvents. Furthermore, the method requires the use of toxic catalysts based on transition metals, which remain in the product. In addition, the copolymers are prone to staining in brown color.

The document US 4888389 describes copolymers which have polyisobutenyl block and a hydrophilic block, such as a polyester unit. Own research, however, showed that described in the document block copolymers are not suitable for obtaining thin compositions of active ingredients.

Summing up we can say that in spite of its fundamental advantages that have amphiphilic block copolymers to create compositions of water-soluble existing and effector substances in water or in aqueous media, known from the level of the ehniki the copolymers are not completely satisfactory, is very complex, the stability of aqueous compositions of active ingredients is not satisfactory, the activity of active substances is a negative impact or require large amounts of polymers, in terms of the active substance, together with high costs and also when applying such compositions may have a negative effect.

The present invention was therefore based on the task to develop substances that allow the efficient solubilization of water-insoluble active substances in the aquatic environment. These substances shall, in particular, be suitable, to provide aqueous compositions of active substances water-insoluble active substances, which do not have or have only a very low content of volatile organic substances. Next, the desired high stability obtained when using these substances aqueous compositions of active substances in relation to processes emulgirovanija during long-term storage, with the addition of the electrolyte and when diluted with water.

This problem is solved in an unexpected way with the help of compositions compositions of polymers that can be obtained by interaction

a) at least one hydrophobic polymer P1, which is reactive towards isocyanate groups functional is e group R ^P1and which is made of ethanobotany monomers M1, including:

A1) at least 10 wt.%, in terms of the total amount of monomers M1, of monomers MA General formula I

where X is oxygen or a group N-R⁴;

R¹means C₁-C₁₀-alkyl, C₅-C₁₀-cycloalkyl, phenyl or phenyl-C₁-C₄-alkyl;

R²means hydrogen or C₁-C₄-alkyl;

R³means hydrogen or C₁-C₄-alkyl; and

R⁴means hydrogen or C₁-C₄-alkyl;

A2) up to 90 wt.%, in terms of the total amount of monomers M1, neutral monomethylethanolamine monomers M1b, the water-solubility of which at 25°C. is less than 50 g/l and which are different from monomers MA; and

A3) up to 30 wt.%, in terms of the total amount of monomers M1, ethanobotany monomers MS, which are different from monomers MA and M1b,

b) at least one hydrophilic polymer P2, which is reactive towards isocyanate groups of the groups R^P2,

(C) with at least one containing the isocyanate group of compound V, which has isocyanate group functionality of at least 1,5.

Thus, the invention described here relates to amphiphilic polymer compositions is the s, and the way they are received.

Amphiphilic polymer composition according to the invention is preferably suitable to stabilize the current and effector substances that are poorly soluble or even insoluble in water, in the aqueous phase and therefore allow the receiving water compositions such existing and effector substances. Unlike described in the prior art block copolymers can be solubilisate in the aqueous phase of large quantity of active compound calculated on the polymer.

The object of the present invention is, therefore, the application of the described amphiphilic polymer compositions for stabilization in the aquatic environment existing, respectively, effector substances that are poorly soluble or completely insoluble in water.

The object of the present invention is, therefore, the application of the described amphiphilic polymer compositions for the preparation of compositions of water-insoluble or poorly soluble in water current, respectively, effector substances, which are further indicated as well as the composition of the active substance, respectively, the composition of effector substances. Poor solubility in this context means the solubility of the current, respectively effector substances in water below 10 g/l, often below 5 g/l, in particular below 1 g/l and special is but below 0.1 g/l at 25°C and 1013 mbar.

The object of the invention are also compositions of the current, respectively, effector substances which contain at least one poorly soluble, respectively, water-insoluble active substance and/or effect substance and at least one amphiphilic polymer composition described below.

The composition of the active substance, respectively effector substances can be solid or liquid. The preferred form of this composition refers to water, i.e. the liquid composition of the active substance, which has one the aquatic environment as a continuous medium and at least one dispersion medium containing at least one active substance and/or effect substance is in water at 25°C./1013 mbar solubility below 10 g/l and at least one amphiphilic polymer composition.

Obtained by the use of amphiphilic block copolymers according to the invention the aqueous composition of active substances poorly soluble, respectively, are not soluble in water current, respectively, effector substances include, along with an aqueous medium as continuous phase, at least one containing current, respectively, the effector substance phase, in which the current, respectively, the effector substance and amfitil the traveler polymer composition are in the form of aggregates of active substance, accordingly, the effector substance and the amphiphilic polymer components of the polymer composition. This contains current, respectively effector substance phase, thus, forms a dispersed phase, which contains the current, respectively, the effector substance and at least one amphiphilic polymer composition according to the invention. The dispersed phase is very thin, i.e. particles of the dispersed phase have a size clearly below 1 μm. Typically, the average diameter of the particles, which can be determined by scattering, of not more than 500 nm, often not more than 300 nm and is often in the range of from 10 to 300 nm, preferably in the range from 10 to 250 nm, in particular in the range from 20 to 200 nm, or from 20 to 150 nm and particularly preferably in the range from 30 to 100 nm. In principle, phase particles may have a smaller average diameter to molecular-dispersed distribution with a particle size of below registered scattering boundaries (e.g., >10 nm).

Another preferred form of the invention relates to non-aqueous, usually solid or semi-solid compositions of the active substance, which has at least one active substance and/or effect substance is in water at 25°C./1013 mbar solubility below 10 g/l, and contains at least the bottom of the amphiphilic polymer composition, and that basically does not contain or contains only small amounts, ie <10 wt.% water. As further components of these compositions may contain typical for the respective purpose of application of the AIDS and additives.

Compositions according to the invention, i.e. as water and non-aqueous compositions, result in the dilution water preparation of the current, respectively, effector substances, including water continuous phase and at least one containing current, respectively, the effector substance phase with an average particle size clearly below 1 μm, typically not more than 500 nm, often not more than 300 nm, for example, in the range from 10 to 300 nm, preferably in the range from 10 to 250 nm, in particular in the range from 20 to 200 nm, or from 20 to 150 nm and particularly preferably in the range from 30 to 100 nm.

These particle sizes are srednevekovye particle sizes, which can be determined by dynamic scattering. The method for this is known to the expert and are described, for example, in the publications .Wiese D.Distler, Wässige Polymerdispersionen, Wiley-VCH 1999, Kapitel 4.2.1, p. 40ff und dort zitierte Literatur compounds .Auweter, D.Horn, J.Colloid Interf. Sci. 105 (1985) 399, D.Lilge, D.Horn, Colloid Polym. Sci. 269 (1991) 704 or .Wiese, D.Horn, J.Chem. Phys. 94 (1991) 6429.

The term "aqueous medium" and "aqueous phase" here and include in the description below water, mixture of water with up to 10 wt.%, in the recalculation of the mixture, organic solvents that are miscible with water, and solutions of solids in water or in aqueous mixtures. Examples for miscible with water solvents include₃-C₄-ketones, such as acetone and methyl ethyl ketone, cyclic ethers such as dioxane and tetrahydrofuran, With₁-C₄-alkanols, such as methanol, ethanol, n-propanol, isopropanol, n-butanol, tert-butanol, polyols (polyhydric alcohols) and their simple mono - and dimethyl ethers, such as glycol, propandiol, simple etilenglikolevye ether, diethylene glycol, simple diethylethylenediamine ether, simple diethylethylenediamine ether, glycerin, then C₂-C₃-NITRILES, such as acetonitrile and propionitrile, dimethylsulfoxide, dimethylformamide, formamide, ndimethylacetamide, dimethylacetamide, butyrolactone, 2-pyrrolidone and N-organic.

The concept of "functionality" means here and below, the average number of the relevant functional groups on the molecule, respectively, in the polymer chain.

Water composition of active substances according to the invention are characterized by extremely high stability with respect to emulgirovaniu. They can be stored without emulgirovanija few months and also at elevated temperature and/or at greatly varying temperatures. Besides conc the bathrooms dispersion can be diluted with water, without that it leads to the phenomena of emulgirovanija, such as coagulation, crystallization, flocculation or sedimentation. In addition, the compositions have a high tolerance to electrolytes. Moreover, due to the very fine distribution, respectively, very low particle diameter of the dispersed phase increased activity of the active ingredients in comparison with conventional water preparative forms. Another advantage is that the aqueous composition of active substances according to the invention can be produced with a low solvent content (the content of volatile solvents <10 wt.%, in terms of the weight of the composition of the active substance) or even free from solvent content of volatile solvents <1 wt.%, in terms of the weight of the composition of the active substance).

Applied to obtain amphiphilic polymer compositions according to the invention the hydrophobic polymer P1, and hydrophilic polymers P2 are reactive toward isocyanate groups, a functional group R^P1accordingly, R^P2that when the bond formation to react with the isocyanate group of compound V. Examples of suitable functional groups are hydroxyl groups, mercaptopropyl (SH) and primary and secondary amino groups. Preferred functional group and are a hydroxyl group, in particular, attached to aliphatic or ticularities C-atom of the hydroxyl group.

Due to the fact that the containing isocyanate group of compound V in the average molecule have at least a 1.5 isocyanate groups, the reaction of compound V with polymer P1 and polymer P2 are formed, at least partially block copolymers which have at least one hydrophobic polymer block that is made from a hydrophobic polymer P1, and at least one hydrophilic polymer block, which is made from a hydrophilic polymer P2. Unlike amphiphilic copolymers according to the prior art when the blocks are not connected directly with each other, and through the connecting element, which has at least two groups of the urethane and/or urea. In contrast to the copolymers according to the prior art, the obtained amphiphilic polymer compositions, usually in the lookup least neproreagirovavshimi polymer P1 and/or the polymer P2, and symmetric products of interaction that have or exclusively produced from polymers P1 polymer blocks or solely produced from polymers P2 polymer blocks. Still preferred amphiphilic properties of polymer compositions are stored.

As hydrophobic polymers P1 are suitable in principle the IPE all made of ethanobotany monomers M1 polymers, which contain depolimerization on at least 10 wt.%, preferably, at least 30 wt.%, in particular, at least 50 wt.%, particularly preferably at least 60 wt.%, in terms of the total amount of the monomer M1 and the monomer Me and who have the required amount of reactive groups R^P1.

Preferred monomers Me are those in which R³in the formula I is hydrogen. R²means preferably hydrogen or methyl. X is preferably O, NH, NCH₃or NC₂H₅.

R¹means preferably

- C₁-C₁₀-alkyl, such as methyl, ethyl, n-propyl, ISO-propyl, n-butyl, 2-butyl, isobutyl, tert-butyl, 1-pentyl, 2-pentyl, neopentyl, n-hexyl, 2-hexyl, n-axtel, 2-ethylhexyl, 2-propylheptyl or n-decyl, and R²mean = N and R¹in particular, different from methyl;

- C₅-C₁₀-cycloalkyl, such as cyclopentyl, cyclohexyl or methylcyclohexyl, or

- phenyl-C₁-C₄-alkyl, such as benzyl, 1 - or 2-phenylethyl, 1-, 2 - or 3-phenylpropyl.

In particular, R¹means C₁-C₁₀-alkyl, and R²=HR¹in particular, different from methyl.

Particularly preferred monomers MA are esters of acrylic acid with C₂-C₁₀-alkanols (=C₂-C ₁₀-alkylacrylate), such as acrylate, n-butyl acrylate, isobutylamine, tert-butyl acrylate, n-hexylaniline, 2-ethyl hexyl acrylate and 3-propylheptyl, complex ester of methacrylic acid with C₁-C₁₀-alkanols, such as methyl methacrylate, ethyl methacrylate, n-butylmethacrylate, isobutylamine, tert-butylmethacrylate and n-hexyllithium. In addition, the preferred monomers MA are N-(C₂-C₁₀-alkyl)-amides of acrylic acid and methacrylic acid, and N-(C₁-C₂-alkyl)-N-(C₂-C₁₀-alkyl)-amides of acrylic acid and methacrylic acid, for example N-ethylacetamide, N,N-diethylacrylamide, N-butylacrylamide, N-methyl-N-propylacetamide, N-(n-hexyl)acrylamide, N-(n-octyl)acrylamide and the corresponding methacrylamide. In particular, the monomers MA include at least 50 wt.%, in particular, at least 70 wt.%, in terms of the total number of monomers Me at least one C₁-C₄-alkylmethacrylamide (R¹=C₁-C₄-alkyl, R²=CH₃and R³=N), and among them, particularly preferably methyl methacrylate.

Along with the monomers MA hydrophobic polymer P1 may also contain polimerizovannye different from the monomers MA monomers M1b up to 90 wt.%, preferably up to 70 wt.%, in particular up to 50 wt.%, and particularly preferably up to 40 the EU.%, in terms of the total amount of the monomers M1. When it comes to monomethylethanolamine monomers with a solubility <50 g/l and often <20 g/l at 25°C and 1013 mbar. Examples of such monomers are vinylaromatic monomers such as styrene, α-methylsterols, vinyltoluene, and tpolicy with the number of carbon atoms from 2 to 10, preferably β-olefins with the number of carbon atoms from 3 to 10, such as propene, 1-butene, 1-penten, 1-hexene, 1-octene and 1-mission complex vinyl esters of aliphatic carboxylic acids such as vinyl acetate, finalproject, vanillaware, MENILMONTANT, benildeans, vanillaware and ministereth, unsaturated NITRILES such as Acrylonitrile and metallical, halogenated olefins such as vinyl chloride, complex C₁₁-C₂₀-alkalemia esters monomethylethanolamine monocarboxylic acids with the number of carbon atoms is preferably from 3 to 6, for example, C₁₁-C₂₀-alkylacrylate and C₁₁-C₂₀the alkyl methacrylates, such as laurelcrest, laurenmarie, isotridecanol, strideselect, stearylamine, sterilisability, complex di-C₁-C₂₀-alkalemia esters ethanobotany dicarboxylic acids with the number of carbon atoms is preferably from 4 to 8, for example, complex di-C₁-C₂₀-alkalemia esters of fumaric acid or maleina the Oh of the acid, such as dimethylfumarate, dimethylmaleic, dibutylphtalate and dibutylated, complex pillowy esters monomethylethanolamine monocarboxylic acids with the number of carbon atoms is preferably from 3 to 6, such as glycidylmethacrylate and glycidylmethacrylate. Preferred monomers M1b are vinylaromatic monomers and among them especially styrene. In one form of execution, the proportion of monomers M1b is from 1 to 90 wt.%, preferably from 5 to 70 wt.%, in particular from 7 to 50 wt.%, and particularly preferably from 10 to 40 wt.%, in terms of the total amount of the monomers M1. Preferably the total number of monomers MA and M1b is at least 80 wt.%, in particular, at least 90 wt.%, and especially preferably at least 95 wt.% monomers M1.

Along with the monomers MA and, if necessary, M1b polymers P1 can contain primaryservername to 30 wt.%, often not more than 20 wt.%, in particular not more than 10 wt.% or not more than 5 wt.%, in terms of the total amount of monomers M1, ethanobotany monomers MS, which are different from monomers MA and M1b.

The monomers MS preferably selected from among neutral monomethylethanolamine monomers M1c.1, the water-solubility of which at 25°C. is at least 50 g/l, in particular at least 100 g/l and monomethylethanolamine monomer is in MS, which have at least one ionic or an ionisable group.

Examples of monomers M1c.1 are amides of the above-mentioned ethanobotany carboxylic acids, in particular acrylamide and methacrylamide, and N-hydroxyalkylated, in particular N-hydroxyethylamide above ethanobotany carboxylic acids, in particular N-methylolacrylamide and N-methylolmethacrylamide, ethylenevinylacetate NITRILES, such as Methacrylonitrile and acrylnitrile, complex hydroxyalkyl esters mentioned α,β-ethanobotany₃-C₈-monocarboxylic acids and C₄-C₈-dicarboxylic acids, in particular hydroxyethylacrylate, hydroxyethylmethacrylate, 2 - and 3-hydroxypropylamino, 2 - and 3-hydroxypropylmethacrylate, complex vinyl or Alleluia ethers of glycols or alkylpolyglycoside, esters of the above monomethylethanolamine mono - and dicarboxylic acids with C₂-C₄-polyalkylene glycols, in particular esters of these carboxylic acids, especially acrylic acid or methacrylic acid with polyethylene glycol or alkyl-peg, and (alkyl)polietilenglikolya the remainder of such esters and ethers typically has a molecular weight in the range from 100 to 3000. The monomers M1c.1 are then N-vinylamide, t is such as N-vinylformamide, N-vinyl pyrrolidone and N-vinylcaprolactam. The monomers M1c.1 are further bearing urea group monomers, such N-(2-acrylamidoethyl)-imidazolin-2-he and N-(2-methacrylamide)-imidazolin-2-he having aldehyde or ketone group monomers such as 3-(acrylamide)-3-methylbutane-2-he (diacetonitrile), 3-(methacrylamido)-3-methylbutane-2-it, 2,4-dioxopentanoate and 2,4-dioxopentanoate. The proportion of monomers M1c.1 is preferably not more than 20 wt.%, and in particular not more than 10 wt.%, for example from 0.1 to 10, especially from 0.5 to 5 wt.%, in terms of the total amount of monomers M1.

The monomers MS are, in particular, monomethylethanolamine monomers M1.2s that have at least one acid group or at least one anionic group, in particular monomers which have one sulfonylurea group, phosphonoacetate group or one or two carbonisation group, and salts of such monomers, in particular, alkali metal salts, for example sodium or potassium, and ammonium salts. These include ethylenevinylacetate sulfonic acid, in particular vinylsulfonate, 2-acrylamide-2-methylpropanesulfonate, 2-aryloxyalkanoic and 2-methacryloxyethyl, 3 aryloxy - and 3-methacryloxypropyltrimethoxysilane, vinylbenzenesulfonic is a and its salts, ethylenevinylacetate propionic acid, such as vinylphosphonic acid and a complex of dimethyl esters vinylphosphonic acids and their salts and α,β-ethylenevinylacetate₃-C₈-mono and C₄-C₈-dicarboxylic acids, especially acrylic acid, methacrylic acid, crotonic acid, maleic acid, fumaric acid and taconova acid. The proportion of monomers M1c.2s often is not more than 20 wt.%, for example from 0.1 to 20 wt.%, and in particular from 0.5 to 15 wt.%, in terms of the total amount of the monomers M1. In the preferred form of execution of the invention the polymer P1 does not contain or contains depolimerization not more than 0.1 wt.% monomers M1c.2s.

The polymers MS are next monomethylethanolamine monomers MSC that have at least one cationic group and/or one capable of protonation at the water group. The monomers MSC are mainly those that contain capable of protonation of the amino group, Quaternary ammonium group, capable of protonation of aminogroup or quaternization aminogroup. Examples of monomers with the stereoselectivity aminogroups are N-vinylimidazole and vinylpyridine. Examples of monomers with the stereoselectivity aminogroups are salts of N-alkylpyridine and salts of N-alkyl-N'-vinylimidazole what I such as chloride, N-methyl-N'-vinylimidazole or methosulfate. Among the monomers MSK particularly preferred monomers of General formula II

where

R⁵means hydrogen or C₁-C₄-alkyl, in particular hydrogen or methyl,

R⁶, R⁷means independently of each other C₁-C₄-alkyl, in particular methyl, and

R⁸means hydrogen IDN C₁-C₄-alkyl, in particular hydrogen or methyl,

Y represents oxygen, NH or NR⁹where R⁹means₁-C₄-alkyl,

And means₂-C₈-alkylene, for example 1,2-ethandiol, 1,2 - or 1,3-propandiol, 1,4-butanediyl or 2-methyl-1,2-propandiol, which if necessary can be interrupted by 1, 2 or 3 nonadjacent oxygen atoms, and

Z^-means the equivalent of an anion, for example Cl^-, HSO₄^-,¹/₂SO₄^2-or CH₃OSO₃^-,

and R⁸means H free base monomer of the formula II.

Examples of such monomers MSC are 2-(N,N-dimethylamino)acrylate, 2-(m,M-dimethylamino)ethyl methacrylate, 2-(N,N-dimethylamino)ethylacrylate, 3-(N,N-dimethylamino)Propylamine, 3-(N,N-dimethylamino)propylethylene, 2-(N,N-dimethylamino)athletically, 2-(N,N,N-ammonium)acrylate chloride, 2-(N,N,N-ammonium)Edelmetalle is-chloride, 2-(N,N,N-ammonium)athletically-chloride, 3-(N,N,N-ammonium)propylacetamide-chloride, 3-(N,N,N-ammonium)propylenediene-chloride, 2-(N,N,N-ammonium)ethylacrylate-chloride, and the corresponding methosulfate and sulfates. Other suitable monomers MSC are vinylpyridine vinylimidazole and their products cateringservice.

The proportion of monomers MSC is preferably not more than 20 wt.%, for example, from 0.1 to 20 wt.%, in particular from 0.5 to 15 wt.%, and especially preferably from 1 to 10 wt.%, in terms of the total amount of the monomers M1. In one preferred form of execution of the polymer P1 does not contain or contains primaryservername not more than 0.1 wt.% monomers M1c.2k.

The monomers MS also include monomers MS that have two or more non-conjugated ethanobotany double bonds. The proportion of such monomers MS is usually not more than 2 wt.% and especially not more than 0.5 wt.%, in terms of the total amount of the monomers M1. Examples for this are complex, vinyl and allyl esters monomethylethanolamine carboxylic acids, such as allylacetate and alismataceae, di - and polyacrylates di - or polioles, such as etilenglikolevye, etilenglikolevye, potentialities, potentialtheorie, hexadienal is t, hexavalentchromium, triethyleneglycol, Triethylenetetramine, Tris(hydroxymethyl)acontractile and-trimethacrylate, pentaerythrityl and-trimethacrylate, then allyl complex and metallimovie esters of polyfunctional carboxylic acids, such as diallylmalonate, diallylphthalate, diallylphthalate monomers MS are also such compounds as divinylbenzene, divinylacetylene, dialymotion, treelistener, N,N'-divinyl - and N,N'-delimitation-2-it, and methylenebisacrylamide and methylenebismethacrylamide.

According to the invention the polymers P1 are reactive functional group, R^P1that react with isocyanate groups in the formation of ties. The average number of such groups on the polymer molecule (functionality), as a rule, is not more than two and preferably lies in the range from 0.5 to 1.5, and especially in the range from 0.6 to 1.4. The functional group R^P1can be located in the polymer chain and is preferably at the end of the polymer chain.

When applying amphiphilic polymer compositions according to the invention for active substances hydrophobic polymer P1 is preferably srednesemennyh molecular weight in the range of from 500 to 20,000 daltons, and in particular in the range from 1500 to 15000 daltons.

P is the materials P1 in principle known from the prior art, for example, from US 5,556,918 and EP-A 742238. Obtaining them is usually radical polymerization in a solution of monomer M1 in the presence of the initiator and, if necessary, the regulator, provided that the initiator in the decay contains hydroxyl radical (OH-radical) and/or the controller includes HE-group or NH₂-group. Suitable initiators are the organic hydroperoxides, such as tert-butylhydroperoxide, tetrahydropyranyloxy, gololytop.host or 2,2'-azobis(2-methyl-N-(2-hydroxyethyl)propionamide). Suitable regulators are aminoalcohols, aminophenols and especially thioalkyl, such as 3-hydroxypropanoyl, complex 2-hydroxyethyl-3-mercaptopropionic acid and, above all, 2-hydroxilation (mercaptoethanol). If you use one of these regulators, polymerization can be carried out in the presence of a known initiator such as isolater or an organic peroxide, such as azobis-(isobutyronitrile), di-(tert-butyl)peroxide, dodecanedioic, Dibenzoyl peroxide, complex tert-butyl ether peracetic acid or complex tert-butyl ester 2-methylpropanol acid. If the polymerization is carried out in the presence of one of the above regulators, regulator used, generally in amounts of from 0.1 to 5 wt.%, often from 0.2 to 4 wt.% and in particular the spine of from 0.5 to 3 wt.%, in terms of the total number of monomers Ml. The initiators are used generally in amounts of preferably from 0.05 to 5 wt.%, often from 0.1 to 4 wt.% and especially preferably in amounts of from 0.2 to 3 wt.%, in terms of paliperidonesee the monomers M1. Regarding these details in particular the reference on page 3 document EP 742238.

Hydrophilic polymers P2, which have a reactive group, R^P2in principle known to the specialist. It is, as a rule, the polymers that are soluble in water. The solubility of the polymers can be provided by hydrophilic groups, such as carboxamide group, altergruppe, lastampa, oxazolidine, anionic groups, respectively, of acid groups, such as carboxytherapy, sulfonate or vospatgop, major groups, for example, due to primary or secondary amino groups, imidazolone groups, pyridine groups, or by cationic groups, for example stereoselectivity ammonium groups, and stereoselectivity pyrimidine group or stereoselectivity imidazolate groups. Depending on the groups distinguish between non-ionic hydrophobic polymers P2, anionic, respectively, acidic polymers P2 and main, respectively, cationic polymers P2. When the polymers P" it is preferable not to ionic polim the arts, i.e., the fraction of ionic groups, respectively, whether acid, major groups is not more than 0.5 mol/kg of polymer P2 and in particular not more than 0.1 mol/kg of polymer P2.

Examples of nonionic polymers P2 are:

simple aliphatic polyesters, at least 50 wt.% and in particular at least 70 wt.% consist of ethyleneoxide units

the Homo - and copolymers ethanobotany monomers that contain at primaryservername form, at least 50 wt.%, in particular, at least 70 wt.%, in terms of the total amount of the monomers M2, at least one monomethylethanolamine monomer MA, which has a water-solubility of >50 g/l and especially >100 g/l at 25°C./1013 mbar. Suitable monomers MA are named as monomers M1c.1 monomers, in particular, N-vinylacetate, such as N-vinyl pyrrolidone and N-vinylcaprolactam, the above amides monomethylethanolamine monocarboxylic acids, such as methacrylamide, Creamed, the above-mentioned complex hydroxyalkyl esters monomethylethanolamine monocarboxylic acids, such as hydroxyethylacrylate and hydroxyethylmethacrylate, vinyl - and allyl ethers of polyethylene glycol and alkylpolyglycoside, as well as esters of acrylic acid and methacrylic acid with glycols or alkylpolyglycoside.

- gender is(2-methyloxiran) and poly(2-ethyloxazole), and

- esters of poly(α-hydroxycarbonic acid), such as polyglycolide and polylactide.

Examples of suitable anionic polymers P2 are such that have depolimerization the form of at least 30 wt.% and preferably at least 50 wt.%, in terms of the total number of polymer P2, monomethylethanolamine monomers 2b that have an acid group such as carboxyl group, sulfonylurea group, phosphate group or postnational group. Examples of suitable monomers 2b are named in connection with the polymers P1 monomers M1c.2s, for example, α,β-ethylenevinylacetate mono - and dicarboxylic acids, such as acrylic acid, methacrylic acid, feniluksousna acid, monoethanolamine sulfonic acids, such as vinylsulfonic, metallischen, styrelseledamot, 2-acrylamide-2-methylpropanesulfonate and 2-aryloxyalkanoic, ethylenevinylacetate phosphonic acids such as vinylphosphonic, allylphosphonate, metalliferous, 2-acrylamide-2-methylpropanesulfonic acid and 2-arylacetylenes. Along with the above monomers 2b suitable anionic polymers P2 may contain depolimerization form up to 50 wt.% and in particular up to 30 wt.% monomer MA and monomer M1b, and up to 70 wt.% monomer MA.

Examples for p is hodnik cationic polymers P2 are Homo - and copolymers of the above monomethylethanolamine monomers MSC, and copolymers of monomers MSC with monoethanolamine neutral monomers M1c.1.

Among the polymers P2 particularly preferred such that relative to the functional groups R^P2have a functionality F2 in the range from 0.5 to 3 and especially in the range from 0.6 to 2.5.

Srednesemennyh molecular weight polymers P2 determined using GPC with conventional methods, is preferably in the range from 500 to 20,000 daltons, and in particular in the range from 800 to 15000 daltons.

Among the polymers P2 particularly preferred aliphatic polyesters, which are made of at least 50 wt.% and in particular at least 70 wt.% and in particular at least 90 wt.%, in terms of the total weight of ethyleneoxide units. Along with these aliphatic polyesters may contain structural units, which are manufactured from₃-C₄-alkalisation. The polyesters may also have non-hydrogen target group. Particularly preferred polyethers have the following General formula III

R^ameans hydrogen, C₁-C₂₀-alkyl or benzyl,

X represents oxygen or NH,

R^bmeans hydrogen or methyl, and at least 50 mol.%, in particular at least 70 mol.% and preferably at least 90 mol.% groups R 2mean hydrogen,

p is an integer, the average value of which is in the range from 10 to 500, preferably from 20 to 250, in particular from 25 to 100.

Suitable hydrophilic polymers P2-known specialist in this area and in most cases commercially purchased, for example, under the trade name Pluriol® and Pluronic® (BASF-Aktiengesellschaft), Sokalan®, Kollidon® (Homo - and copolymers of monomers MA, 2b and MSC), or can be obtained by known methods.

The overall proportion of hydrophobic polymers P1 amphiphilic polymer composition, i.e. the total number of transformed and not transformed polymer P1, is from 20 to 68 wt.% the total weight of polymer P1 and polymer P2 and connections V.

The overall proportion of hydrophilic polymers P2 in the amphiphilic polymer composition, i.e. the total number of transformed and not transformed polymer P2, ranging from 30 to 78 wt.% the total weight of polymer P1 and polymer P2 and connections V.

The overall proportion of hydrophobic compounds V in the amphiphilic polymer composition, i.e. the total number of used connections V is from 2 to 20 and especially from 2 to 15 wt.% the total weight of polymer P1 and polymer P2 and connections V.

The weight ratio of polymer P1 and P2 in the amphiphilic polymer compositions, each time calculated as the total amount applied for polymers, is in the interval is from 1:10 to 10:1 and in particular, in the range of from 1:4 to 2.2:1.

Suitable compounds V with functionality relative to the isocyanate groups of at least 1.5, in particular from 1.5 to 4.5, and in particular from 1.8 to 3.5 include aliphatic, cycloaliphatic and aromatic di - and polyisocyanates, as well as isocyanurate, allophanate, uretdione and biuret aliphatic, cycloaliphatic and aromatic diisocyanates.

Preferably the connection V have an average of from 1.8 to 3.5 isocyanate groups on the molecule. Examples of suitable compounds V are aromatic diisocyanates such as toluene-2,4-diisocyanate, toluene-2,6-diisocyanate, commercially purchased a mixture of toluene-2,4 - and -2,6-diisocyanate (TDI), n-delete the entry, 3,3'-diphenyl-4,4'-biphenylenediisocyanate, 4,4'-biphenylenediisocyanate, 4,4'-diphenylmethanediisocyanate, 3,3'-dichloro-4,4'-biphenylenediisocyanate, cumin-2,4-diisocyanate, 1,5-naphthalenedisulfonate, p-xylylenediisocyanate, n-delete the entry, 4-methoxy-1,3-delete the entry, 4-chloro-1,3-delete the entry, 4-ethoxy-1,3-delete the entry, 2,4-dimethylene-1,3-finlandisation, 5,6-dimethyl-1,3-delete the entry, simple 2,4-isocyanatophenyl ether, aliphatic diisocyanates, such as atlantaatlanta, utilitisation, propylene-1,2-diisocyanate, 1,6-hexamethylenediisocyanate, 1,4-tetramethyldisilane, 1,10-decamethylenediamine and cycloaliphatic the s diisocyanate, such as isophoronediisocyanate (IPDI), cyclohexene-1,2-diisocyanate, cyclohexyl-1,4-diisocyanate, and bis(4,4'-isocyanatophenyl)methane. Among diisocyanato preferred such isocyanate groups which differ in reactivity-ability, such as toluene-2,4-diisocyanate, toluene-2,6-diisocyanate, mixtures thereof, and CIS - and TRANS-isophorondiisocyanate.

In another preferred form of execution of the invention to obtain amphiphilic compositions according to the invention applied biuret or isocyanurate aliphatic or cycloaliphatic diisocyanate compounds, such as cyanuric tetramethyldisilane or hexamethylenediisocyanate.

To obtain amphiphilic compositions according to the invention the hydrophobic polymer P1 and the hydrophilic polymer P2 is subjected to interact sequentially or simultaneously with the compound V under conditions in which the group R^P1accordingly, R^P2react with isocyanate groups in the formation of the connection.

The interaction may be carried out in the presence or absence of small amounts customary for this purpose, the catalysts which promote the formation of urethanes, respectively, of urea. Suitable catalysts are, for example, tertiary amines, such as triethylamine, tri-n-Propylamine, N-methylpyrrolidine, N-methylpiperidine and diazabicyclo (ABCO), ORGANOTIN compounds, in particular salts dialkylamino (IV) aliphatic carboxylic acids, such as dibutyltindilaurate and debutylation, diaconate tin (II), such as diktat tin and cesium salt, such as cesium acetate. If desired, the catalyst is used in an amount of not more than 0.1 wt.%, in terms of the connection V, for example, in amounts of from 0.01 to 0.1 wt.%, in particular, up to 0.05 wt.%.

The required reaction temperature depends on the reactivity of functional groups, R^P1accordingly, R^P2and from isocyanate compounds V and, if applicable, the type and amount of catalyst, it is usually from 10 to 120°C. and especially from 15 to 85°C.

Needless to say that the interaction of the polymers P1 and P2 with the isocyanate compound V is carried out in the absence of moisture (water content of preferably <10000 mlnc and in particular <2000 mlnc).

The interaction can occur in the substance or in an organic solvent which is inert to isocyanate connection groups V. Examples for suitable solvents are aliphatic ketones, such as acetone, methyl ethyl ketone, cyclohexanone, Sonya alkalemia esters of aliphatic carboxylic acids, for example methyl acetate, ethyl acetate, methylpropionate, ethylpropyl, n-butylacetate, aliphatic illecebra ethers, such as diethyl ether, diisopropyl ether, methyl tert-butyl ether, tetrahydrofuran, aromatic, aliphatic and alicyclic hydrocarbons, such as toluene, xylene, hexane, cyclohexane, and N-alkilany, such as N-organic and mixtures of these solvents.

The interaction of polymer P1 and polymer P2 with compound V can be consistently if at the same time, i.e. the polymers P1 and P2 can interact with the connection V sequentially or simultaneously.

If the polymers P1 and P2 is subjected to interaction with connection V series, you can interact first polymer P1 with a connection V and then the polymer P2 with a connection V, and Vice versa.

If the polymers P1 and P2 is subjected to interaction with connection V series, then the interaction is carried out preferably in such a way that after completion of engagement with the first polymer P1 or P2, at least 10 mol.% to 90 mol.%, in particular from 20 mol.% up to 80 mol.% isocyanate groups in the compound V is reacted with the functional groups R¹accordingly, R²and 10 to 90 mol.%, in particular, from 20 to 80 mol.% available isocyanate groups still exist. In conclusion, spend the interaction with the second polymer P1 or P2. Preferably the first polymer P1 or P2 is transformed into a quantity that the molar ratio of the group of reactive groups R ^P1accordingly, R^P2to the number of isocyanate groups per mole of compound V is in the range from 0.1:1 to 0.9:1 and especially in the range from 0.2:1 to 0.8:1. Then, the thus obtained product is subjected to interaction with the second polymer and the second polymer P1 or P2 are applied in such quantity that the total number of reactive groups R^P1+R^P2corresponds at least to the number of isocyanate groups of the compounds V. Preferably, the ratio of R^P1+R^P2to the total number of isocyanate groups does not exceed 1.2:1.

If the polymers P1 and P2 is subjected to interaction with the isocyanate compound V at the same time, preferably the polymers P1 and P2 are applied in such a quantity that the molar ratio of reactive groups R^P1+R^P2to isocyanate groups is at least 1:1. Preferably the ratio of R^P1+R^P2to the total number of isocyanate groups does not exceed 1.2:1.

Isocyanate compound V can be used in the reaction of interaction as such. However, you can also use isocyanate compounds V in this form, in which a portion of isocyanate groups reversibly blocked with a protective group. Compounds that block the isocyanate group (to mask or protect)described in the literature (see, for example, the publication is then W. Wicks, Prog. Org. Coat. 3(1975) 73-99, and 9(1981) 3-28 or Houben-Weyl, Methods der Organischen Chemie, Bd. XIV/2, S.61 ff., Georg Thieme Verlag, Stuttgart 1963). As a means of blocking isocyanate groups should be called, for example, phenols, caprolactam, imidazoles, pyrazoles, pyrazolinone, 1,2,4-triazole, diketopiperazine, ester of malonic acid or oximes, To achieve success according to the invention, however, does not require the use of partially reversibly blocked isocyanate.

In one particularly preferred form of execution of the invention receive the first reaction stage hydrophobic polymer P1 radical polymerization in solution as described above and carried out in the thus obtained reaction mixture interaction with isocyanate V in the manner described, without isolation to this polymer P1. Then the reaction mixture is subjected to interaction with the polymer P2, preferably polyester. Alternatively, the desired number of polymer P2 to submit to the obtained polymers P1 and then to interact with the connection V.

To obtain the aqueous compositions of active substances obtained according to the invention the polymer composition can be isolated from the reaction mixture, it is also possible to apply the reaction mixture as such.

In another preferred form of execution of the invention applied to the teachings of the polymeric composition, the solvent is replaced partially or completely with water, consequently obtain a water dispersion of the amphiphilic polymer composition. This can be done, for example, due to the fact that the solvent is first evaporated and then the residue is dispersed in water or in an aqueous environment. Also to the solution of the polymeric composition, you can add water and solvent to remove at the end of the supplements of water or in parallel to it.

A composition of the active substance, respectively, effector substances according to the invention can be implemented in various ways. A typical way of obtaining the composition of the active substance, respectively, effector substances according to the invention includes receiving, respectively, providing a homogeneous, non-aqueous mixture comprising ampivillin. polymer composition and at least one active substance and/or effect substance.

In the first form of implementation of the present invention the aqueous composition of active substances are obtained in such a way that you get a homogeneous, not water mixture consisting of amphiphilic polymeric composition and the active substance and/or effect substance and thus obtained mixture is dispersed in water or in an aqueous environment. To obtain a homogeneous, not water mixture, as a rule, the active substance verbatimout in liquid form amphiphilic polymer to which notizie, for example, the melt or preferably a solution in an organic solvent. If you use a solvent, in conclusion, it mostly or completely removed, and get the solution of the active substance in the amphiphilic polymer composition. Suitable solvent is one which can dissolve both the active substance and the polymer, for example, aliphatic NITRILES, such as acetonitrile and propionitrile, N,N-dialkylamide aliphatic carboxylic acids, such as dimethylformamide and dimethylacetamide, N-alkilany, such as N-organic, the above aliphatic and alicyclic ethers, such as tetrahydrofuran, halogenated hydrocarbons such as dichloromethane, dichloroethane and mixtures of the mentioned solvents. To obtain the aqueous compositions according to the invention in conclusion, the obtained solid solution of the active substance is dispersed by stirring. Mixing can be carried out at ambient temperatures and at elevated temperature, for example, in the range from 10 to 80°C. and especially in the range from 20 to 50°C.

When the second form of implementation of the present invention, the receiving water of the composition of the active substance is carried out by obrabotki active substance and/or effector substances in aqueous solution/dispersion ampip the school polymeric composition. To do this, usually do so that obrabotka carried out at a temperature which lies above the melting temperature of the current, respectively, effector substances and preferably at a temperature at which the melt of the current, respectively, effector substances of low viscosity, i.e. has a viscosity in the range from 1 to 1000 MPa·s (Germany standard DIN 53019-2 at 25°C). Preferably obrabotka is made of strong cutting efforts, for example, in Ultraturrax.

When the third form of implementation of the present invention, the receiving water of the composition of the active substance is carried out by a process comprising the following stages from a to C:

a) obtaining a solution of the active substance and/or effect substance and, if necessary, amphiphilic polymer composition in an organic solvent which has a boiling point below the boiling point of water, and

b) mixing the solution of the active substance and/or effector of a substance with water or with an aqueous solution of amphiphilic copolymer and

c) removing the solvent.

With this alternative you can do so that the solution of the active substance contains amphiphilic polymer composition, and this solution is mixed with water or solution of the active substance contains only part of the amphiphilic polymer component is icii or does not contain amphiphilic polymer compositions and this solution is mixed with an aqueous solution or dispersion of the amphiphilic polymer composition. The mixing may be carried out in a suitable mixer, and you can apply water or an aqueous solution of amphiphilic polymer compositions and submit to him the solution of active substance or effect substance and or submit an alternative solution active substance or effect substance and water to it, accordingly, an aqueous solution of amphiphilic polymeric composition. In conclusion, removing the solvent, e.g. by distillation, and, if necessary, add water.

In one preferred embodiment of this form of execution of the present invention the solution of the active substance and water, respectively, an aqueous solution of amphiphilic polymer compositions served continuously in the mixing zone and from it choose the mixture, from which finally remove the solvent. The mixing zone can be performed by anyone. In principle suitable for this all apparatus which allows continuous mixing of flows of liquids. Such apparatus is known, for example, from the publication of the Continuous Mixing of Fluids (J.-H. Henzler) in Ullmann''s Encyclopedia 5 th ed. on CD-Rom, Wiley-VCH. The mixing zone can be performed as a static or dynamic mixer or a mixing of forms. As mixing zones are suitable, in particular, Jet mixers or similar mixers with nozzles. In a preferred form of execution when the mixing zones we are talking about is described in the Handbook "Handbook of Industrial Crystallization" (A.S.Myerson, 1993 Butterworth-Heinemann, page 139, ISBN 0-7506-9155-7) apparatus or comparable devices.

The volume ratio of the solution of the active substance to water, respectively, aqueous solution of amphiphilic polymer compositions can vary within a wide range and is preferably from 10:1 to 1:20 and in particular from 5:1 to 1:10.

Naturally, the solvent should be suitable for dissolving the amphiphilic polymer composition and active ingredient in the desired proportions. Suitable solvent may be installed by a specialist. Examples for suitable solvents are₂-C₄-alkanols, such as ethanol, n-propanol, n-butanol, Isobutanol, the above-mentioned aliphatic and alicyclic ethers, such as diethyl ether, diisopropyl ether, methyl tert-butyl ether, dioxane, tetrahydrofuran, ketones, such as acetone, methyl ethyl ketone.

In another form of the present invention receive a non-aqueous composition of the active substance so that you get a homogeneous, non-aqueous mixture of amphiphilic polymeric composition and the active substance and/or effector substances. This song, if it does not contain liquid components, as a rule, is solid. On receipt of such compositions is really said about the first form, issue the log homogeneous non-aqueous mixture, consisting of amphiphilic polymeric composition and the active substance and/or effector substances, however, there may be vraboteni if necessary desirable additives and auxiliary agents in the composition. This option is suitable for non-aqueous compositions.

For compositions of the active substance according to the invention has the advantage that if the weight ratio of the active substance and/or effector substances to the amphiphilic polymer composition is in the range from 1:10 to 3:1 and especially in the range from 1:5 to 2:1.

The content of active and/or effector substances can vary within wide limits. In particular amphiphilic polymer compositions allow obtaining concentrates of the active substance, which contain the active substance in a quantity of at least 5 wt.%, for example, in an amount of 5 to 50 wt.% and especially in an amount of 5 to 20 wt.%, in terms of the total weight of the composition,

Preferably the compositions according to the invention, especially the aqueous composition of the active substance, can be prepared without solvent or with a small amount of solvent, i.e., the fraction of volatile components in the composition of the active substance is often not more than 10 wt.%, in particular, not more than 5 wt.% and in particular not more than 1 wt.%, virescence on the total weight of the composition. Volatile components are such that under normal pressure have a boiling point below 200°C.

In the compositions according to the invention can be vraboteni many different existing and effector substances. A special form of the present invention relates to active substances for plant protection, i.e. such as herbicides, fungicides, nematicides, acaricides, insecticide and active substances that regulate the growth of plants.

Examples of fungicidal active substances that are present in the compositions according to the invention include:

- acylalanines, such as benalaxyl, metalaxyl, operate, oxadixyl;

- amine derivatives, such as Aldemar, dodine, dodemont, fenpropimorph, fenpropidin, guazatine, iminoctadine, spiroxamine, tridemorph;

- anilinopyrimidines, such as Pyrimethanil, mepanipyrim or Cyrodiil;

antibiotics, such as cycloheximide, griseofulvin, kasugamycin, natamycin, polyoxin, streptomycin and validamycin;

- azoles, such as bitertanol, bromuconazole, cyazofamid, tsyprokonazolu, difenoconazol, dinitrocresol, epoxiconazol, etridiazole, fenbuconazole, fluquinconazole, flusilazole, flutriafol, fuberidazole, hexaconazole, hymexazol, imazalil, ipconazole, kabekona, metconazole, myclobutanil, pancreatol, parfois the rat, propiconazol, prochloraz, prothioconazole, simionato, tebuconazole, tetraconazole, thiabendazol, triadimefon, triadimenol, triflumizole, triticonazole, 2-butoxy-6-iodine-3-propylparaben-4-one, 3-(3-bromo-6-fluoro-2-methylindol-1-sulfonyl)-[1,2,4]triazole-1-acid-dimethylamide;

- 2-methoxybenzophenone, such as described in EP-A 897904 General formula I, for example, metrafenone;

- dicarboximide, such as iprodione, mickleton, procymidon, vinclozolin;

- dithiocarbamate, such as FeRAM, nabam, MANEB, MANCOZEB, METAM, metiram, propineb, polycarbamate, thiram, Zir, zineb;

- heterocyclic compounds, such as aniline, benomyl, boscalid, carbendazim, carboxin, oxycarboxin, cyazofamid, dazomet, dithianon, ethirimol, dimethirimol, famoxadone, fenamidone, fenarimol, fuberidazole, flutolanil, parameter, isoprothiolane, mepronil, nuarimol, Actelion, picotamide, provenzal, proquinazid, pirivenas, pyroquilon, quinoxyfen, silthiofam; thiabendazol, teriflunomide, thiophanate-methyl, tadini, tricyclazole, triforine, 3-[5-(4-chlorophenyl)-2,3-dimethyl-isoxazolidine-3-yl]-pyridine and bupirimate;

derivatives nitrophenyl, such as binapacryl, dinocap, dinobuton, nitrite-isopropyl;

- phenylpyrrole, such as fenpiclonil and fludioxonil;

not classified fungicides, such as acibenzolar-S-methyl, benthiavalicarb,cropropamide, CHLOROTHALONIL, cyflufenamid, having cymoxanil, declomycin, diclocil, deepeners, edifenphos, ethaboxam, fenhexamid, fentin-acetate, phenoxyl, verison, fluazinam, fosetyl, fosetyl-aluminum, Ivalice, hexachlorobenzene, metrafenone, pencycuron, propamocarb, phtalic, tolclofos-methyl, quintozene, zoxamide, isoprothiolane, fluopicolide (picobenzide); cropropamide, mandipropamid, N-(2-{4-[3-(4-chlorophenyl)-prop-2-ynyloxy]-3-methoxyphenyl}ethyl)-2-methanesulfonamido-3-methyl-butyramide, N-(2-{4-[3-(4-chlorophenyl)-prop-2-ynyloxy]-3-methoxyphenyl}-ethyl)-2-ethanolamine-3-methylbutyrate; parameter, leflunomid, antipirate, fenhexamid, (2-cyanophenyl)-amide 3,4-dichloroisothiazol-5-carboxylic acid, flubendiamide, 3-methyl ester (4-chlorophenyl)-3-(2-isopropoxycarbonyl-3-methyl-Butylimino)-propionic acid, methyl ester {2-chloro-5-[1-(6-methylpyridin-2-imitationen)-ethyl]-benzyl}-carbamino acid, methyl ester {2-chloro-5-[1-(3-methylbenzylamino)-ethyl]-benzyl}-carbamino acid, flutolanil, amide of the formula

where

X means CHF₂or CH₃; and

R¹, R²mean independently from each other halogen, methyl or halogenmethyl, for example, CF₃;

strobilurin, such as described in WO 03/075663 General formula I, for example, AZOXYSTROBIN, dimixer the bin, fluoxastrobin, kresoxim-methyl, metamyosyn, orysastrobin, picoxystrobin, pyraclostrobin and Trifloxystrobin;

derivatives of sulfonic acids, such as captafol, Captan, dichlofluanid, folpet, tolylfluanid;

- amides of cinnamic acid and analogues, such as dimethomorph, fromtower, floorp;

- 6-aryl-[1,2,4]triazolo[1,5-a]pyrimidines described, for example, in documents WO 98/46608, WO 99/41255 or WO 03/004465 General formula I, for example,

5-chloro-7-(4-methylpiperidin-1-yl)-6-(2,4,6-tryptophanyl)-[1,2,4]triazolo[1,5-a]pyrimidine;

- fungicides-based amide, such as cyclopentane, and (Z)-N-[β-(cyclopropylmethoxy)-2,3-Diptera-6-(deformedarse)benzyl]-2-phenylacetamide.

Examples of herbicides that can be contained in the compositions according to the invention, are the following:

- 1,3,4-thiadiazole, such as booteasy and cobresol;

- amides, such as ellidaar, benzoylpropionic, bromobutyl, chlorine, timepart, dimethenamid, diphenamid, etamesonic, lampropeltis, fosamine, isoxaben, metazachlor, monolid, naptalam, pronamide, propanil;

- aminophosphine acid, such as milanapos, buminate, glufosinateammonium, glyphosate, sulfosate;

- aminotriazole, such as amitrol,

- anilide, such as anilofos, mefenacet;

- aryloxyalkanoic acid, such as 2,4-D, 2,4-DB, clomipram, dichlorprop, dichlorprop-R, Hairdryer the prop, fluroxypyr, MSRA, MSRB, mecoprop, mecoprop-R, napropamide, nitroanilide, triclopyr;

benzoic acid, such as chloramben, dicamba;

- benzothiadiazine, such as bentazon;

bleaches, such as clomazone, diflufenican, fluorochloridone, flupoxam, fluridone, pyrazolate, sulcotrione;

- carbamates, such as carbetamide, chloroform, chlorpropham, desmedipham phenmedipham, vernolate;

- quinolinic acid such as chinkara, hinnerk;

- dichloropropionate acid such as dalapon;

- dihydrobenzofuranyl, such as ethofumesate;

- dihydrofuran-3-one, such as flurtamone;

- dinitroaniline, such as dinitroaniline, benefin, Butylin, dinitramine, ethalfluralin, fluchloralin, isopropylene, nicraly, oryzalin, pendimethalin, prodiamine, propleuron, trifluralin,

- dinitrophenol, such as bromophenoxy, dinoseb, dinoseb-acetate, dinoterb, DNOC, dinoterb-acetate;

- simple diphenyl ethers, such as acifluorfen-sodium, klonipin, bifenox, chlornitrofen, direxion, idoxifene, fluorodifen, fluorodifen-ethyl, fomesafen, voreloxin, lactofen, nitrofen, nitrofluorene, oxyfluorfen;

- dipyridyl, such as cibercut, difenzoquat-methyl sulfate, Diquat, paraquat-dichloride;

- imidazoles, such as isosorbid;

- imidazolinone, such as imazamethabenz, imazapyr, imazaquin,amazement-methyl, imazethapyr, imazapic, imazamox;

- oxadiazole, such as metasol, oxadiargyl, oxadiazon;

- oxirane, such as tridiphane;

- phenols, such as bromoxynil, ioxynil;

- phenoxypropionate esters, such as clodinafop, cyhalofop-butyl, diclofop-methyl, fenoxaprop-ethyl, fenoxaprop-p-ethyl, pentabromide, fluazifop-butyl, fluazifop-p-butyl, haloxyfop-ethoxy-ethyl, haloxyfop-methyl, haloxyfop-p-methyl, isocaporate, propaquizafop, quizapp-ethyl, quizapp-p-ethyl, quizalofop-tefuryl;

- phenylacetic acid, such as chlorgenic;

- phenylpropionate acid, such as chloroform-methyl;

- ppi-active substances, such as benzien, flumiclorac-pentyl, flumioxazin, flubiprofen, flypaper, percocette, sulfentrazone, mediatime;

- pyrazoles, such as snipercraft;

- pyridazine, such as chloridazon, maleic hydrazide, norflurazon, peridot;

- pyridineboronic acid, such as clopyralid, dithiopyr, picloram, thiazopyr;

- simple pyrimidinone esters, such as pyrithiobac, pyrithiobac-sodium, KIH-2023, KIH-6127;

sulfonamides, such as flumetsulam, metosulam;

- thiazolecarboxamide, such as threatened;

- orally, such as bromacil, lenacil, terbacil;

next benazolin, benfluralin, bensulide, benzofur, bentazon, butamifos, Catanzaro, x is Ortal-dimethyl, cinetel, dichlobenil, endothall, fluoranthrene, mefluidide, pehlivan, piperophos, topramezone and prohexadione-calcium;

- sulfonylureas such as amidosulfuron, azimsulfuron, busulphan-methyl, chlorimuron-ethyl, chlorsulfuron, cynosurion, cycloolefin, ethanesulfonic-methyl, flazasulfuron, halosulfuron-methyl, imazosulfuron, metsulfuron-methyl, nicosulfuron, primisulfuron, prosulfuron, pyrazosulfuron-ethyl, rimsulfuron, sulfometuron-methyl, thifensulfuron-methyl, triasulfuron, tribenuron-methyl, triflusulfuron-methyl, tritosulfuron;

- active substances of plant protection type cyclohexenone, such as aloxide, clethodim, chloroxygen, cycloxydim, sethoxydim and tralkoxydim. Especially preferred herbicide active substances are herbicide active ingredients type of cyclohexanone: tepraloxydim (cf. AGROW, Nr. 243, 3.11.95, page 21, Caloxydim) and 2-(1-[2-{4-chlorphenoxy}propyl-oxyimino]butyl)-3-hydroxy-5-(2H-tetrahydrothiopyran-3-yl)-2-cyclohexen-1-he type sulfonylureas: N-(((4-methoxy-6-[trifloromethyl]-1,3,5-triazine-2-yl)amino)carbonyl)-2-(trifluoromethyl)-benzosulfimide.

Examples of insecticides which may be contained in the compositions of active substances according to the invention include:

- organo(thio)phosphates, such as Arafat, azamethiphos, Azinphos-tatIl, Hazi the FOS-methyl, the chlorpyrifos, chlorpyrifos-methyl, Chlorfenvinphos, dichlorvos, dimethylene, dioxybenzone, dicrotophos, dimethoate, disulfoton, ethion, EPN, fenitrothion, fenthion, isoxathion, Malathion, methamidophos, methidathion, methyl-parathion, mevinphos, monocrotophos, oxydemeton-methyl, paraoxon, pupation, pentat, fozalon, phosmet, phosphamidon, Fort, phoxim, pirimiphos-methyl, profenofos, prothiofos, pirimiphos-ethyl, pyraclofos, predatation, sulprofos, triazophos trichlorfon tetrachlorvinphos, vamidothion,

- carbamates, such as alankar, benfuracarb, bendiocarb, carbaryl, carbofuran, carbosulfan, fenoxycarb, furathiocarb, indoxacarb, methiocarb, methomyl, oxamyl, pirimicarb, propoxur, thiodicarb, triazamate;

pyrethroids, such as allethrin, bifenthrin, cyfluthrin, cyphenothrin, cicloprofen, cypermethrin, deltamethrin, esfenvalerate, etofenprox, fenpropathrin, fenvalerate, cigalotrin, lambda cigalotrin, imiprothrin, permethrin, prallethrin, pyrethrin I, pyrethrin II, selflove, Tau-fluvalinate, tefluthrin, tralomethrin, transfluthrin, alpha-cypermethrin, Zeta-cypermethrin, permethrin;

Atropatene growth regulators: (a) inhibitors of the synthesis of chitina, such as benzoylacetone, such as chlorfluazuron, cyromazine, diflubenzuron, flucycloxuron, flufenoxuron, hexaflumuron, lufenuron, novaluron, teflubenzuron, triflumuron; buprop the zine, giovenale, hexythiazox, etoxazole, clofentezine; (b) actionee antagonists, such as halogenated, methoxyfenozide; tebufenozide; (C) wonodi, such as pyriproxyfen, methoprene, fenoxycarb; (d) inhibitors of the biosynthesis of lipids, such as spirodiclofen;

- the neonicotinoids, such as neonicotinoids, such as flonicamid, clothianidin, dinotefuran, Imidacloprid, thiamethoxam, nitenpyram, nithiazine, acetamiprid, thiacloprid;

Other clasificadosonline insecticide, such as abamectin, achiezer, acetamiprid, amitraz, azadirachtin, bensultap, bifenazate, cartap, chlorfenapyr, Chlordimeform, cyromazine, diafenthiuron, dinotefuran, giovanola, emamectin, endosulfan, eliprodil, fenazaquin, fipronil, formetanate, formetanate hydrochloride, gamma-HCH hydramethylnon, Imidacloprid, indoxacarb, isoprocarb, metolcarb, pyridaben, pymetrozine, spinosad, tebufenpyrad, thiamethoxam, thiocyclam, pyridalyl, flonicamid, flurazepam, milbemectin, spiromesifen, blueradios, NC 512, toppenberg, flubendiamide, bistriflate, banknotes, perflubron, periphral amidolytic, lufenuron, titlemotion, achiezer, leemartin, perflutren, dimefluthrin, amerson, metaflumizone, N-R'-2,2-dihalo-1-R"-cyclopropanecarboxamide-2-(2,6-dichloro-β,β,β-tri-fluoro-p-tolyl)hydrazone, N-R'-2,2-di(R"')propionamide-2-(2,6-dichloro-β,β,β-Cryptor-p-tolyl)-hydrazone, and halo who appoints chlorine or bromine, R' denotes methyl or ethyl, R" denotes hydrogen or methyl and R"' is methyl or ethyl, CMS and killchar, as well as compounds of the following formula

aminotetrazole formula

where R is-CH₂O-CH₃or H and

R' oznachaet-CF₂CF₂CF₃;

anthranilamide formula

where R oznachaet₁-C₄-alkyl, such as methyl, ethyl, isopropyl or n-butyl, compound of formula

- N-phenylsemicarbazone described in EP-A 462456 General formula I, particularly compounds of General formula IV

where R¹¹and R¹²independently of one another denote hydrogen, halogen, CN, C₁-C₄-alkyl, C₁-C₄-alkoxy, C₁-C₄-haloalkyl or₁-C₄-haloalkoxy and R¹³means₁-C₄-alkoxy, C₁-C₄-haloalkyl or₁-C₄-haloalkoxy, for example, compound IV,

where R¹¹mean 3-CF₃and R¹²means 4-CN, and R¹³means 4-F₃(metaflumizone).

Acceptable growth regulators are, for example, chlormequat-chloride, meekathara, prohexadione-calcium or group of gibberellins. These include, for example, gibberellin GA₁, GA₃, GA_{4 , GA5and GA7etc. and the corresponding Exo-16,17-dihydrohelenalin, as well as their derivatives. for example, esters with C1-C4-karbonovymi acids. According to the invention preferred Exo-16,17-dihydro-GA5-13-acetate, then 1-naphthylacetamide, 1 naphthyloxy acid, 2-naftiluksusnaya acid, 3-CPA, 4-CPA, ancymidol, anthraquinone, VAR, butiphos; tribufos, Butylin, then chlorflurazole, clofencet, cyclanilide, daminozide, dicamba, dikegulac sodium, dimethipin, florfenicol, eracelzel, ethephon, articleset, fenoprop, 2,4,5-TP, fluoridated, flurried, flutriafol, guazatine, imazalil, indolylmethane acid, indelicacy acid, Karmazin, kinetin, lactideco-ethyl, maleic hydrazide, mefluidide, naptalam paclobutrazol, hinnerk, Sonthofen, tetcyclacis, tridiazuron triiodobenzoate, thiapentanal, triacetin, tribufos, trinexapac-ethyl and uniconazole.}

The preferred form of carrying out the invention relates to the use of amphiphilic polymer compositions according to the invention to obtain the aqueous compositions of active ingredients, such as fungicides, in particular strobilurines, azoles and 6-alltrista[1,5-a]pyrimidines described, for example, in WO 98/46608, WO 99/41255 or WO 03/004465 General formula I, in particular for active substances of General formula V,

where

R^xmeans a group NR¹⁴R¹⁵or unbranched or branched C₁-C₈-alkyl, which, if necessary, substituted with halogen, HE, C₁-C₄-alkoxy, phenyl or₃-C₆-cycloalkyl,₂-C₆alkenyl,₃-C₆-cycloalkyl,₃-C₆-cycloalkenyl, phenyl or naphthyl, and 4 of the last residue may have 1, 2, 3, or 4 substituent selected from the group comprising halogen, HE₁-C₄-alkyl, C₁-C₄-halogenoalkane, C₁-C₄-alkoxy and C₁-C₄-halogenated;

R¹⁴, R¹⁵independently of one another denote hydrogen, C₁-C₈-alkyl, C₁-C₈-halogenated,₃-C₁₀-cycloalkyl,₃-C₆-halogenosilanes,₂-C₈alkenyl,₄-C₁₀-alkadienes,₂-C₈-halogenoalkanes,₃-C₆-cycloalkenyl,₂-C₈-halogennitroalkanes,₂-C₈-quinil, C₂-C₈-halogenoalkanes or₃-C₆-cycloalkenyl,

R¹⁴and R¹⁵together with the nitrogen atom to which they are attached, form a five - to eight-membered heterocyclyl, which is attached via N and contains two or three further heteroatoms from the group O, N and S as ring members and/or may have one or more the of deputies, selected from the group comprising halogen, C₁-C₆-alkyl, C₁-C₆-halogenated,₂-C₆alkenyl,₂-C₆-halogenoalkanes, C₁-C₆-alkoxy, C₁-C₆-halogenase,₃-C₆-alkenylamine,₃-C₆-halogenations, (Exo)-C₁-C₆-alkylene and hydroxy-C₁-C₃-alkylene;

L is selected from the group comprising halogen, cyano, C₁-C₆-alkyl, C₁-C₄-halogenated, C₁-C₆-alkoxy, C₁-C₄-halogenoalkane and C₁-C₆-alkoxycarbonyl;

L¹means halogen, C₁-C₆-alkyl or C₁-C₆-halogenated and in particular fluorine or chlorine;

X means halogen, C₁-C₄-alkyl, cyano, C₁-C₄-alkoxy or C₁-C₄-halogenated and preferably halogen or methyl and in particular chlorine.

Examples for compounds of formula V are 5-chloro-7-(4-methylpiperidin-1-yl)-6-(2,4,6-tryptophanyl)-[1,2,4]triazolo[1,5-a]pyrimidine, 5-chloro-7-(4-methylpiperazin-1-yl)-6-(2,4,6-tryptophanyl)-[1,2,4]triazolo[1,5-a]pyrimidine, 5-chloro-7-(morpholine-1-yl)-6-(2,4,6-tryptophanyl)-[1,2,4]triazolo[1,5-a]pyrimidine, 5-chloro-7-(piperidine-1-yl)-6-(2,4,6-tryptophanyl)-[1,2,4]triazolo[1,5-a]pyrimidine, 5-chloro-7-(morpholine-1-yl)-6-(2,4,6-tryptophanyl)-[1,2,4]triazolo[1,5-a]pyrimidine, 5-chloro-7-(isopropylamino)-6-(2,4,6-triterpene is)-[1,2,4]triazolo[1,5-a]pyrimidine, 5-chloro-7-(cyclopentylamine)-6-(2,4,6-tryptophanyl)-[1,2,4]triazolo[1,5-a]pyrimidine, 5-chloro-7-(2,2,2-triptoreline)-6-(2,4,6-tryptophanyl)-[1,2,4]triazolo[1,5-a]pyrimidine, 5-chloro-7-(1,1,1-tryptophan-2-ylamino)-6-(2,4,6-tryptophanyl)-[1,2,4]triazolo[1,5-a]pyrimidine, 5-chloro-7-(3,3-dimethylbutan-2-ylamino)-6-(2,4,6-tryptophanyl)-[1,2,4]triazolo[1,5-a]pyrimidine, 5-chloro-7-(cyclohexylmethyl)-6-(2,4,6-tryptophanyl)-[1,2,4]triazolo[1,5-a]pyrimidine, 5-chloro-7-(cyclohexyl)-6-(2,4,6-tryptophanyl)-[1,2,4]triazolo[1,5-a]pyrimidine, 5-chloro-7-(2-methylbutane-3-yl)-6-(2,4,6-tryptophanyl)-[1,2,4]triazolo[1,5-a]pyrimidine, 5-chloro-7-(3-methylbutane-1-yl)-6-(2,4,6-tryptophanyl)-[1,2,4]triazolo[1,5-a]pyrimidine, 5-chloro-7-(4-methylcyclohexane-1-yl)-6-(2,4,6-tryptophanyl)-[1,2,4]triazolo[1,5-a]pyrimidine, 5-chloro-7-(hexane-3-yl)-6-(2,4,6-tryptophanyl)-[1,2,4]triazolo[1,5-a]pyrimidine, 5-chloro-7-(2-methylbutane-1-yl)-6-(2,4,6-tryptophanyl)-[1,2,4]triazolo[1,5-a]pyrimidine, 5-chloro-7-(3-methylbutane-1-yl)-6-(2,4,6-tryptophanyl)-[1,2,4]triazolo[1,5-a]pyrimidine, 5-chloro-7-(1-methylpropan-1-yl)-6-(2,4,6-tryptophanyl)-[1,2,4]triazolo[1,5-a]pyrimidine, 5-methyl-7-(4-methylpiperidin-1-yl)-6-(2,4,6-tryptophanyl)-[1,2,4]triazolo[1,5-a]pyrimidine, 5-methyl-7-(4-methylpiperazin-1-yl)-6-(2,4,6-tryptophanyl)-[1,2,4]triazolo[1,5-a]pyrimidine, 5-methyl-7-(morpholine-1-yl)-6-(2,4,6-tryptophanyl)-[1,2,4]triazolo[1,5-a]pyrimidine, 5-methyl-7-(piperidine-1-yl)-6-(2,4,6-tryptophanyl)-[1,2,4]triazolo[1,5-a]pyrimidine, 5-methyl-7-(morpholine-1-yl)-6-(2,4,6-tryptophanyl)-[1,2,4]triazolo[1,5-a]pyrimidine, 5-ethyl-7-(isopropylamino)-6-(2,4,6-tryptophanyl)-[1,2,4]triazolo[1,5-a]pyrimidine, 5-methyl-7-(cyclopentylamine)-6-(2,4,6-tryptophanyl)-[1,2,4]triazolo[1,5-a]pyrimidine, 5-methyl-7-(2,2,2-triptorelin)-6-(2,4,6-tryptophanyl)-[1,2,4]triazolo[1,5-a]pyrimidine, 5-methyl-7-(1,1,1-tryptophan-2-ylamino)-6-(2,4,6-tryptophanyl)-[1,2,4]triazolo[1,5-a]pyrimidine, 5-methyl-7-(3,3-dimethylbutan-2-ylamino)-6-(2,4,6-tryptophanyl)-[1,2,4]triazolo[1,5-a]pyrimidine, 5-methyl-7-(cyclohexylmethyl)-6-(2,4,6-tryptophanyl)-[1,2,4]triazolo[1,5-a]pyrimidine, 5-methyl-7-(cyclohexyl)-6-(2,4,6-tryptophanyl)-[1,2,4]triazolo[1,5-a]pyrimidine, 5-methyl-7-(2-methylbutane-3-yl)-6-(2,4,6-tryptophanyl)-[1,2,4]triazolo[1,5-a]pyrimidine, 5-methyl-7-(3-methylpropan-1-yl)-6-(2,4,6-tryptophanyl)-[1,2,4]triazolo[1,5-a]pyrimidine, 5-methyl-7-(4-methylcyclohexane-1-yl)-6-(2,4,b-tryptophanyl)-[1,2,4]triazolo[1,5-a]pyrimidine, 5-methyl-7-(hexane-3-yl)-6-(2,4,6-tryptophanyl)-[1,2,4]triazolo[1,5-a]pyrimidine, 5-methyl-7-(2-methylbutane-1-yl)-6-(2,4,6-tryptophanyl)-[1,2,4]triazolo[1,5-a]pyrimidine, 5-methyl-7-(3-methylbutane-1-yl)-6-(2,4,6-tryptophanyl)-[1,2,4]triazolo[1,5-a]pyrimidine and 5-methyl-7-(1-methylpropan-1-yl)-6-(2,4,6-tryptophanyl)-[1,2,4]triazolo[1,5-a]pyrimidine.

Another preferred form of the invention relates to the use of amphiphilic polymer compositions according to the invention to obtain the aqueous compositions of active substances, in particular water compositions of insecticides, in particular arilpirolul, such as chlorfenapyr, pyrethriods, such as bifenthrin, cyfluthrin, cyclo is motrin, cypermethrin, deltamethrin, esfenvalerate, etofenprox, fenpropathrin, fenvalerate, cigalotrin, lambda cigalotrin, permethrin, selflove, Tau-fluvalinate, tefluthrin, tralomethrin, plfa-cypermethrin, Zeta-cypermethrin and permethrin, neonicotinoids and semicarbazones formula IV.

In addition, the amphiphilic polymer composition according to the invention is suitable for obtaining water compositions pharmaceutical active compounds and prodrugs. To them are benzodiazepines, antihypertensive, vitamins, cytostatics, in particular Taxol, anesthetics, neuroleptics, antidepressants, antibiotics, antimitotic, fungicides, chemotherapy tools, urological tools, platelet aggregation inhibitors, sulfonamides, spazmoliticheskie tools, hormones, immunoglobulins, sera, remedies for thyroid, psychopharmaceuticals funds funds against parkinsonism and other hypertensive funds oftalmica funds neuraminidase drugs, calcium metabolism regulators, muscle relaxants, anaesthesia funds, funds reduce the level of lipids in the blood, for the treatment of liver, coronary tools, tools heart, immunotherapy, regulatory peptides and their inhibitory substances, sleeping pills, sedatives, GI is the ecological funds the remedy against gout, fibrinolysis means, enzyme preparations and transport proteins, enzyme inhibitors, material resources, tools, promoting blood circulation, diuretics, diagnostic tools, corticoid, cholinergic agents; agents used to treat biliary tract, protivoastmatichesky tools, Bronkhorst, beta-blockers, calcium antagonists, ACE inhibitors, anti-arteriosclerosis, anti-inflammatories, Universiada funds antihypotensive funds antihyperglycemics funds antihypertensive funds antifibrinolytic tools, anti-epileptic tools, antiemetic, protivorakovye tools, antidiabetics, anti-arrhythmic means, Antianemic tools, anti-allergic drugs, sedative, analgesics, analepticheskih tools, aldosterone antagonists, tools for weight loss. Examples of suitable pharmaceutical active substances are given in paragraphs 0105 up 0131 document US 2003/0157170 active substances.

Next amphiphilic polymer composition according to the invention suitable for aqueous compositions, cosmetic active substances, in particular cosmetic oils and fats such as peanut butter, jojob the oil, the coconut oil, almond oil, olive oil, palm kernel oil, castor oil, soybean oil or wheat sound oil, essential oils such as pine oil, lavender oil, rosemary oil, pine oil, pine, eucalyptus oil, peppermint oil, sage oil, bergamot oil, turpentine oil, balm oil, juniper oil, lemon oil, anise oil, cardamom oil, camphor oil ipili mixtures of these oils.

In addition, the amphiphilic polymer composition according to the invention is suitable for obtaining the compositions, particularly aqueous compositions of additional funds to the food products, such as water-insoluble vitamins and provitamins, such as vitamin a, vitamin a acetate, vitamin D, vitamin E, derivatives of tocopherol, such as tocopherol acetate and vitamin K.

Examples of effector substances that may be contained in the compositions according to the invention, are the following:

dyes: for example described in document DE-A 10245209 dyes, and also indicated according to the color index as disperse dyes or solvent dyes compounds, which are referred to as dispersion dyes. An overview of suitable dispersion dyes can be found, for example, Ullmanns Enzyklopädie der technischen Chemie, 4. Auflag, Bd.10, S.155-165 (see also volume 7, str and then antrahinonovye dyes; volume 8, str further azo dyes; volume 9, str and next - chiropterotriton). This literary source and named it the connection is given corresponding reference. Suitable according to the invention the dispersion dyes and solvent dyes include various classes of dyes with different chromophores, for example antrahinonovye dyes, monoazo and diazatricyclo, hinaplanon, Metin and athletically, naphthaleneacetic, naftokhimikukrainy and microcrystal. Examples for suitable according to the invention dyes are dispersive dyes of the following list of color index: S Disperse Yellow I - 228, S Disperse Orange 1-148, S Disperse Red 1-349, S Disperse Violet 1-97, S Disperse Blue 1-349, S Disperse Green 1-9, S Disperse Brown 1-21, S Disperse Black 1-36. Examples for suitable according to the invention of solvents and dyes are compounds of the following list of color index: S Solvent Yellow 2-191, S Solvent Orange 1-113, S Solvent Red 1-248, S Solvent Violet 2-61, S Solvent Blue 2-143, S Solvent Green 1-35, S Solvent Brown 1-63, S Solvent Black 3-50. Further suitable according to the invention dyes are derivatives of naphthalene, anthracene, peri Lena, terylene, quarterly and dyes on the basis of diketopiperazine, perineoscrotal, coumadinmedical, isoindoline and isoindolines, porphyrins the bearers, phthalocyanine - and

naphthalocyanines; and absorbers of ultraviolet rays: in particular, compounds of the following groups:

4) 4,4-derivatively,

5) an ester of cinnamic acid,

6) benzotriazole,

7) hydroxybenzophenone,

8) diphenylcyanoarsine,

9) oxamide,

10) 2-phenyl-1,3,5-triazine;

Group 4) 4,4-derivativeof are, for example, the compounds of formula A.

Compounds known from the document EP-A-916 335. The substituents R₁₀and/or R₁₁preferably means C₁-C₈-alkyl or C₅-C₈-cycloalkyl.

Group 5) esters of cinnamic acid are, for example, a complex 2-isoamyl ether ether 4-methoxycatechol acid, a complex 2-ethylhexyloxy ether 4-methoxycatechol acid, methyl-α-metastrongylidae, methyl-α-cyano-β-methyl-p-methoxycinnamate, butyl α-cyano-β-methyl-p - p-methoxycinnamate and methyl-α-methoxycarbonyl - p-methoxycinnamate.

Group 6) benzotriazoles are, for example, 2-(2'-hydroxyphenyl)-benzotriazoles, such as 2-(2'-hydroxy-5'-were-benzotriazol, 2-(3',5'-di-tert-butyl-2'-hydroxyphenyl)benzotriazol, 2-(5'-tert-butyl-2'-hydroxyphenyl)-benzotriazole, 2-(2'-hydroxy-5'-(1,1,3,3-TETRAMETHYLBUTYL)phenyl)benzotriazole, 2-(3',5'-di-tert-butyl-2'-hydroxyphenyl)-5-chloro-benzotriazole, 2-(3'-tert-butyl-2'-hydroxy-5'-IU is ylphenyl)-5-chloro-benzotriazole, 2-(3'-sec-butyl-5'-tert-butyl-2'-hydroxyphenyl)-benzotriazole, 2-(2'-hydroxy-4'-octyloxyphenyl)-benzotriazole, 2-(3',5'-di-tert-amyl-2'-hydroxyphenyl)-benzotriazole, 2-(3',5'-bis-(α,α-dimethylbenzyl)-2'-hydroxyphenyl)-benzotriazole, 2-(3'-tert-butyl-2'-hydroxy-5'-(2-octyloxybiphenyl)phenyl)-5-chloro-benzotriazole, 2-(3'-tert-butyl-5'-[2-(2-ethylhexyloxy)-carbonylethyl]-2'-hydroxyphenyl)-5-chloro-benzotriazole, 2-(3'-tert-butyl-2'-hydroxy-5'-(2-methoxycarbonylethyl)phenyl)-5-chloro-benzotriazole, 2-(3'-tert-butyl-2'-hydroxy-5'-(2-methoxycarbonylethyl)phenyl)-benzotriazole, 2-(3'-tert-butyl-2'-hydroxy-5'-(2-octyloxybiphenyl)phenyl)-benzotriazole, 2-(3'-tert-butyl-5'-[2-(2-ethylhexyloxy)carbonylethyl]-2'-hydroxyphenyl)-benzotriazole, 2-(3'-dodecyl-2'-hydroxy-5'-methylphenyl)-benzotriazole and 2(3'-tert-butyl-2'-hydroxy-5'-(2-isooctylmercaptoacetate)-phenylbenzothiazole, 2,2'-methylene-bis[4-(1,1,3,3-TETRAMETHYLBUTYL)-6-benzotriazol-2-yl-phenol]; the product of the esterification of 2-[3'-tert-butyl-5'-(2-methoxycarbonylethyl)-2'-hydroxyphenyl]-2H-benzotriazole with polyethylene glycol 300; [R-CH₂CH₂-COO(CH₂)₃]₂, where R is 3'-tert-butyl-4'-hydroxy-5'-2H-benzotriazol-2-yl-phenyl, and mixtures thereof.

To the group of 7) hydroxybenzophenones are, for example, 2-hydroxybenzophenone, such as 2-hydroxy-4-methoxybenzophenone, 2,2'-dihydroxy-4-methoxybenzophenone, 2,4-dihydroxybenzophenone, 2,2',4,4'-tetrahydroxy opinon, 2,2'-dihydroxy-4,4'-dimethoxybenzophenone, 2,2'-dihydroxy-4,4'-dimethoxybenzophenone, 2-hydroxy-4-(2-ethyl-hexyloxy)benzophenone, 2-hydroxy-4-(n-octyloxy)benzophenone, 2-hydroxy-4-methoxy-4'-methylbenzophenone, 2-hydroxy-3-carboxybenzene, 2-hydroxy-4-methoxybenzophenone-5-acid and its sodium salt, 2,2'-dihydroxy-4,4'-dimethoxybenzophenone-5,5'-bisulphite and its sodium salt.

To group 8) diphenylcyanoarsine include, for example, ethyl-2-cyan-3,3-diphenylacetate, which may be purchased under the name Uvinul® 3035 BASF AG, Ludwigshafen, 2-ethylhexyl-2-cyan-3,3-diphenylacetate, which may be purchased under the name Uvinul® 3039 BASF AG, Ludwigshafen, and 1,3-bis-[(2'-cyano-3',3'-diphenylacetyl)oxy]-2,2-bis{[2'-cyano-3',3'-diphenylamino)oxy]methyl} propane, which may be purchased under the name Uvinul® 3030 BASF AG, Ludwigshafen.

In group 9) oxamide include, for example, 4,4'-distractionware, 2,2'-diethoxyaniline, 2,2'-dioctyloxy-5,5'-di-tert-butoxylated, 2,2'-didodecyl-5,5'-di-tert-butoanele, 2-ethoxy-2'-ethyloxazole, N,N'-bis(3-dimethylaminopropyl)oksamid, 2-ethoxy-5-tert-butyl-2'-etoxazole and its mixture with 2-ethoxy-2'-ethyl-5,4'-di-tertbutoxide. as well as a mixture of ortho-, para-methoxy-disubstituted oxanilide and mixtures of ortho - and para-ethoxy disubstituted oxanilide.

The group of 10) 2-phenyl-1,3,5-triazines include, for example, 2-(2-hydrox is phenyl)-1,3,5-triazine, such as 2,4,6-Tris(2-hydroxy-4-octyloxyphenyl)-1,3,5-triazine, 2-(2-hydroxy-4-octyloxyphenyl)-4,6-bis(2,4-dimetilfenil)-1,3,5-triazine, 2-(2,4-dihydroxyphenyl)-4,6-bis(2,4-dimetilfenil)-1,3,5-triazine, 2,4-bis(2-hydroxy-4-proproxyphene)-6-(2,4-dimetilfenil)-1,3,5-triazine, 2-(2-hydroxy-4-octyloxyphenyl)-4,6-bis(4-were)-1,3,5-triazine, 2-(2-hydroxy-4-dodecyloxyphenyl)-4,6-bis(2,4-dimetilfenil)-1,3,5-triazine, 2-(2-hydroxy-4-tridecylalcohol)-4,6-bis(2,4-dimetilfenil)-1,3,5-triazine, 2-[2-hydroxy-4-(2-hydroxy-3-Butylochka-propoxy)phenyl]-4,6-bis(2,4-dimethyl)-1,3,5-triazine, 2-[2-hydroxy-4-(2-hydroxy-3-octyloxy-propoxy)phenyl]-4,6-bis(2,4-dimethyl)-1,3,5-triazine, 2-[4-(dodecyloxy/tridecylamine-2-hydroxypropoxy)-2-hydroxyphenyl]-4,6-bis(2,4-dimetilfenil)-1,3,5-triazine, 2-[2-hydroxy-4-(2-hydroxy-3-dodecyloxyethoxy)phenyl]-4,6-bis(2,4-dimetilfenil)-1,3,5-triazine, 2-(2-hydroxy-4-hexyloxyphenyl)-4,6-diphenyl-1,3,5-triazine, 2-(2-hydroxy-4-methoxyphenyl)-4,6-diphenyl-1,3,5-triazine, 2,4,6-Tris[2-hydroxy-4-(3-butoxy-2-hydroxy-propoxy)phenyl]-1,3,5-triazine and 2-(2-hydroxyphenyl)-4-(4-methoxyphenyl)-6-phenyl-1,3,5-triazine.

Along with the above components of the aqueous composition of active substances according to the invention can also contain conventional surfactants and other additives. To the surfactant include surfactants, dispersing agents and wetting. Other additives including the SJ in particular thickeners, the foam remover, preservatives, antifreeze agents, stabilizers and the like.

Acceptable in principle are anionic, Cotonou, paninya and amphoteric surfactants and polymeric surfactants, and surfactants with heteroatoms in the hydrophobic group.

For anionic surface-active substances include, for example, carboxylates, in particular alkali, alkaline earth, ammonium salts of fatty acids, such as potassium stearate, which are usually referred to as soap; acellularity; sarcosinate, for example, laurylsarcosine sodium; taurate; methycellulose; alkylphosphate, particularly for complex alkalemia esters of mono-and diphosphines acid; sulfates, in particular the alkyl sulphates and alkylarylsulfonate; sulfonates, other alkyl - and alkylarylsulfonates, particularly alkaline, alkaline earth and ammonium salts arylsulfonyl, as well as alkyl substituted arylsulfonyl, alkylbenzenesulfonate, such as, for example, lignin -, and phenolsulfonate, naphthalene - and dibutyldithiocarbamate or dodecylbenzensulfonate, alkylnaphthalene, sulfonates complex alkylation ethers, condensation products from sulphonated naphthalene and its derivatives with formaldehyde, condensation products of naphthalenesulfonic, phenol - and/or phenolsulfonic with what ledegem or with urea, the sulfonates esters of mono - or dialkylamino acids and protein hydrolysates and lignin-sulphite waste liquor. The above sulfonic acids are used preferably in the form of their neutral or, if necessary, basic salts.

For cationic surface-active substances include, for example, stereoselectivity ammonium compounds, in particular, halides and alkyl sulphates of alkyltrimethylammonium and dialkyldimethylammonium and pyrimidine derivatives and imidazoline, especially alkylpyridine.

For non-ionic surfactants are, for example:

- complex polyoxyethylene ethers of fatty alcohols, such as polyoxyethylenesorbitan lauric alcohol,

- simple alkyl-polyoxyethylene and polyoxypropylene ether, such as ISO-tridecylamine alcohol and simple polyoxyethylene ether of fatty alcohol series,

- simple polyoxyethylene ether alkylarenes, for example a simple octyphenol-polyoxyethylene ether,

- alkoxysilane animal and/or vegetable fats and/or oils, for example corn oil ethoxylates, castor oil ethoxylates, ethoxylates of fat,

- complex glycerol esters, glycerylmonostearate,

- alkoxylates of fatty alcohols and alkoxylates of oxaspiro, particularly RO-(R₁₈O)_{r (R19O)sR20where R18and R19independently from each other mean}

With₂H₄With₃H₆C₄H₈and R₂₀means N, or C₁-C₁₂is alkyl, R is C₃-C₃₀-alkyl or

With₆-C₃₀alkenyl, r and s independently of one another denote numbers from 0 to 50, both cannot mean 0, such as ISO-tridecylamine alcohol and simple polyoxyethylene ether alilovic spirits,

- alkylphenolethoxylate, as for example, ethoxylated ISO-axtel, axtel or nonyl-phenol, simple tributyltin-polyoxyethylene ether,

- alkoxylated fatty amine number, amicalmente fatty acid and diethanol-amicalmente fatty acids, especially their ethoxylates,

sugar surfactants, arbitarily ether, for example ester sorbinovoj fatty acids (servicemanual, corbettreport), ester polyoxyethylenesorbitan acid, alkylpolyglycoside, N-Alkylglucoside,

- alkylarylsulfonate,

- alkyldimethylammonium, for example

- tetradecyltrimethylammonium.

To amphoteric surface-active substances include, for example, sulfobetaine, carboxybutyl and alkyldimethylammonium, such as tetradecyltrimethylammonium.

Other surface-active substances, the cat is who should be named are performancei, silicone surfactants, phospholipids, such as lecithin or chemically modified latticini, detergents amino acids, for example N-lauroylgultamate.

If they were not specified, the alkyl chains of the above surfactants talking about unbranched or branched residues with the number of carbon atoms from 8 to 20.

In one preferred form of execution of the invention the aqueous composition of active substances according to the invention contain not more than 10 wt.%, preferably not more than 5 wt.% and especially not more than 3 wt.%, for example from 0.01 to 5 wt.% or from 0.1 to 3 wt.% regular surface-active substances, each time calculated on the total amount of active ingredient and polymer composition. Regular surface-active substances are then preferably not more than 5 wt.% and especially not more than 3 wt.%, for example from 0.01 to 5 wt.% or from 0.1 to 3 wt.%, in terms of the total weight of the composition.

Depending on the application may have an advantage, if the composition of active substances according to the invention prepared with surfactants. Then the share of conventional surfactants is often in the range of from 0.5 to 30 wt.%, in particular in the range from 1 to 20 wt.%, in terms of the total number of current the substances and polymer compositions accordingly, in the interval from 0.2 to 20 wt.% and especially in the range from 0.5 to 15 wt.%, in terms of the total number composed of the composition.

If the advantage of the compositions according to the invention is a low content of volatile organic substances may be desirable for some applications, mix composition according to the invention with organic solvents, oils and fats, preferably such solvents or oils and fats, which are acceptable in relation to the environment and biocompatible, for example, the above mixed with water, the solvent or solvents, oils and fats, which is not miscible or only sparingly miscible with water, such as:

paraffin oil, aromatic hydrocarbons and aromatic mixture of hydrocarbons, such as xylene, Solvesso 100, 150 or 200, and so on,

- phenols and alkyl phenols, such as phenol, hydroquinone, Nonylphenol, etc.

- ketones with more than 4 carbon atoms, such as cyclohexanone, isophorone, isophoron, acetophenone, acetonaphthone,

- alcohols with more than 4 carbon atoms, such as acetylated lanolin alcohol, cetyl alcohol, 1-decanol, 1-heptanol, 1-hexanol, isooctanol, isopropyl alcohol, alerby alcohol, benzyl alcohol,

an ester katlanovo acid, for example, complex dialkyl the initial ester of adipic acid, such as complex bis(2-ethylhexyl)ester adipic acid, complex diakidoy ether talavou acid, such as bis(2-ethylhexyl)ester talavou of kisladag, complex alkilany ether acetic acid (also branched alkyl groups), such as ethyl acetate and complex ethyl ester of acetoacetic acid, stearates, such as butilstearat, glycerylmonostearate, citrates, such as acetyltributyl, then tetrachromat, methyl oleate, methyl-p-hydroxybenzoate, methylacridinium, propyl-p-hydroxybenzoate, methylbenzoate, ester of lactic acid, such as isopropylacetate, and butylacetat 2-ethylhexylamine,

vegetable oils such as palm oil, rapeseed oil, castor oil and derivatives thereof, such as, for example, oxidized, coconut oil, fish oil, corn oil, soybean oil, flax seed oil, olive oil, peanut oil, safflower dye, contuinue oil, pampelmuse oil, Basil oil, apricot kernel oil, imbernon oil, geranium oil, orange oil, rosemary oil, macadamiamac, onion oil, tangerine oil, pine oil, sunflower oil,

- hydrogenomonas vegetable oils, such as hydrogenomonas palmae oil, hydrogenomonas rapeseed oil, soybean oil,

- animal oils, such as olive oil pork W the RA, fish oils, dialkylamide medium to long chain fatty acid series, for example gallamine, and

- esters of vegetable oils, such as methyl ester of rapeseed oil.

Suitable thickeners are compounds that give the songs a pseudo-plastic property, i.e. high viscosity at rest and low viscosity in a mobile state. It should be called, for example, polysaccharides, respectively, organic layered minerals, such as Xanthan Gum® (Kelzan® company Keico), Rhodopol® 23 (Rhone Poulenc) or Veegum® (R.T. Vanderbilt) or Attaclay® (Engelhardt), and Xanthan-Gum® is used preferably.

As suitable for dispersions according to the invention of antispyware should be called, for example, silicone emulsions (such as, for example, silicone® SRE, Wacker or Rhodorsil® company Rhodia), long-chain alcohols, fatty alcohols, organofluorine compounds and mixtures.

Bactericides can be used to stabilize the compositions according to the invention against microorganisms. Suitable bactericides are, for example, Proxel® company ICI or Acticide® RS firm Thor Chemie and Kathon® MK company Rohm & Haas.

Suitable antifreeze agents are organic polyols, such as ethylene glycol, propylene glycol or glycerin. They are usually used in an amount of not more than 10 wt.%, in lane the account on the total weight of the composition dejstvuusih substances, not to exceed relieve the content of volatile compounds. In one form of the invention the proportion of different volatile organic compounds is preferably not more than 1 wt.%, in particular not more than 1000 mlnc

If necessary, the composition of active substances according to the invention may contain from 1 to 5 wt.% buffer, in terms of the total number produced compositions for regulating the pH value, and the number and type of this buffer is focused on the chemical properties of the active substance, respectively, of active substances. Examples of the buffer are alkali metal salts of weak inorganic or organic acids, such as phosphoric acid, boric acid, acetic acid, propionic acid, citric acid, fumaric acid, tartaric acid, oxalic acid and succinic acid.

Depending on the form contained the active substance, respectively, effector substances of the composition of active substances, respectively, effector substances according to the invention can be applied in the usual formulation and composition of the active substance, respectively, effector substances. For example, the composition of the active substance, which contain at least one insecticidal, acaricidal or nematode current is emesto, used to fight insects, acaricides or nematodes. If the composition of the active substance according to the invention contain at least one fungicidal active ingredient, they can be used to control pathogenic fungi. If the composition of the active substance according to the invention contain herbicide active ingredient, they can be used to fight useless cereals and similar weeds.

Depending on the form of the active substance composition of the active substance according to the invention are used in particular to protect plants from destruction of pathogenic humps and the like, such as insects, acaricide, nematodes, or for protection from damage by phytopathogenic fungi, etc. or when the seed treatment or the protection of materials, for example, to protect lignocellulosic materials such as wood, from the defeat of pathogenic insects, such as eating wood beetles, termites, ants and the like, or from destruction of staining or damaging the wood mushrooms.

Needless to say, the compositions according to the invention can also be used in cosmetics, whether in medicine or in technical fields.

The invention is explained below in more detail using the following examples.

I. Receiving amphiphilic polymer composition.

1444 g of tetrahydrofuran is heated under reflux. Within 2 hours serves simultaneously tributary 1A, consisting of 2109 g of methyl methacrylate and 703 g of styrene, and tributary 1b, consisting of 1444 g tetrahydrofuran (THF), 18.6 g azobisisobutyronitrile (AIBN) and 58,4 g of mercaptoethanol and the mixture kept for 24 h under heating under reflux. Then serves 430 g of a commercially available biureta of hexamethylenediisocyanate (NCO-content of 22%, viscosity at 23°C To 4.0 PA·s) and 0.1 g of dilaurate dibutylamine and the reaction mixture is stirred while maintaining the temperature up until the NCO content of the mixture falls to 1.02%. then to the mixture is added 3000 g of methyl-terminated of polyethylene oxide (srednesemennyh molecular weight of 2000 daltons, a number of CON 33 mg/g (solids) and stirred the reaction mixture while maintaining the temperature up until the NCO content reaches 0%. Then added dropwise within 30 minutes of 14.7 kg of water and distilled tetrahydrofuran under reduced pressure. Thus, receive a 30 wt.%-percent aqueous dispersion of the amphiphilic polymer composition with an average particle size of 50 nm (specific dynamic scattering).

I.2 Example of getting 2.

1444 g of tetrahydrofuran is heated under reflux. Within 2 hours serves simultaneously tributary 1A, consisting of 2109 g of methyl methacrylate is 703 g of styrene, and tributary 1b, consisting of 1444 g tetrahydrofuran (THF), 18.6 g azobisisobutyronitrile (AIBN) and 58,4 g of mercaptoethanol and the mixture kept for 24 h under heating under reflux. Then add 167 g isophorondiisocyanate and 0.7 g of dilaurate dibutylamino and the reaction mixture is stirred while maintaining the temperature up until the NCO content will not fall to 0.53%. Then to the mixture is added 500 g of methyl-terminated of polyethylene oxide (srednesemennyh molecular weight of 2000 daltons, a number of CON 33 mg/g Festsubstanz) and stirred the reaction mixture while maintaining the temperature up until the NCO content reaches 0%. Then added dropwise within 30 minutes 10, 6 kg of water and distilled tetrahydrofuran under reduced pressure. Thus, receive a 30 wt.%-percent aqueous dispersion of the amphiphilic polymer composition with an average particle size of 52 nm (specific dynamic scattering).

I.3 Example of getting 3.

1444 g of tetrahydrofuran is heated under reflux. Within 2 hours serves simultaneously tributary 1A, consisting of 2109 g of methyl methacrylate and 703 g of styrene, and tributary 1b, consisting of 1444 g tetrahydrofuran (THF), 18.6 g azobisisobutyronitrile (AIBN) and 58,4 g of mercaptoethanol and the mixture kept for 24 h under heating under reflux. Then serves 430 g of a commercially available biureta of hexamethylenediisocyanate (NCO-soda is the content of 22%, viscosity at 23°C. Of 4.0 PA·s) and 3000 g of methyl-terminated of polyethylene oxide (srednesemennyh molecular weight of 2000 daltons, a number of CON 33 mg/g solids) and 0, 86 g of dilaurate dibutyrate and stirred the reaction mixture while maintaining the temperature up until the NCO content reaches 0%. Then added dropwise within 30 minutes of 14.76 kg of water and distilled tetrahydrofuran under reduced pressure. Thus, receive a 30 wt.%-percent aqueous dispersion of the amphiphilic polymer composition with an average particle size of 52 nm (specific dynamic scattering).

I.4 Example 4.

430 g applied in the example of a 1 normal sales biureta of hexamethylenediisocyanate, 3000 g metilen-terminated of polyethylene oxide (OH-number of 33 mg KOH/g solids) and 117 mg of dilaurate dibutyrate dissolved in 3430 g of tetrahydrofuran. The solution was stirred at the temperature of the back of the fridge up until the NCO content will not be 0,46%.

1444 g of tetrahydrofuran is heated under reflux. Within 2 hours serves simultaneously tributary 1A, consisting of 2109 g of methyl methacrylate and 703 g of styrene, and tributary 1b, consisting of 1444 g tetrahydrofuran (THF), 18.6 g azobisisobutyronitrile (AIBN) and 58,4 g of mercaptoethanol and the mixture kept for 24 h under heating under reflux. Then add meanwhile polucen is the first product of the interaction of biureta of hexamethylenediisocyanate with methylaminopropane the polyethylene oxide and the reaction mixture is stirred while maintaining the temperature until until the NCO content is not 0%. Then added dropwise within 30 minutes of 14.7 kg of water and distilled in vacuum tetrahydrofuran. Thus, receive a 30 wt.%-percent aqueous dispersion of the amphiphilic polymer composition with an average particle size of 52 nm (specific dynamic scattering).

II. Receiving water compositions of the active substance according to the invention.

II.1 Analyst.

See the viscosity was determined by a rotary viscometer according to DIN 53019-2.

Determination of the average diameter of the particles was carried out by the method of static light scattering on dilute the sample water compositions according to the invention at 20°C.

To test the storage stability of an aqueous composition of the active substance was stored for 2 weeks at 54°C and 2 weeks at 5°C. in Addition, the compositions according to the invention froze and was again thawed. The storage stability there when these conditions are not observed any sedimentation or separation.

II.2 General rules for the receipt.

1. Method solubilisate (liquid active substances and melts of active substances).

10 g of active substance vmeshivat in 90 g water dispersion of amphiphilic polymeric composition containing 30 g of the polymer at the temperature at which the active substance has as low-viscosity melt. In may the STI from the viscosity of the polymer solution and melt the active substance carry out the mixing in the application of a magnetic stirrer or Ultraturrax. The time required to balance solubilisation depends on the polymer composition and the active substance may take a few seconds or several hours. The balance of solubilisation is achieved when the active substance is evenly distributed in the mixture and, despite the further introduction of energy, no changes are observed particle sizes.

2. The method of phase inversion.

10 g of liquid or solid active ingredient and 30 g of the amphiphilic polymer composition (the content of polymers >95%wt.) dissolved in an organic solvent which has a boiling point below 100°C. (e.g., tetrahydrofuran). Then, under stirring, water is added, and then the organic solvent is distilled off. Add enough water that the resulting aqueous composition is 10 wt.% active ingredient and 30 wt.% the polymer.

3. Method of solid solution.

0.5 g of the amphiphilic polymer composition (polymer content >95%wt.) and 0.1 g of active substance are dissolved in approx. 20 ml of dimethylformamide. The solvent is then completely removed (for example, in a rotary evaporator), so it remains solid solution of a hydrophobic active substance and the amphiphilic polymer composition. To the reaction mixture an aqueous solution with buffer (100 ml, pH 6.8) and the mixture is stirred for 24 hours. PEFC is filtering the solution analyzed by HPLC detector (ultraviolet rays) and determine the concentration of the active substance.

4. Dose sedimentation.

30%of the aqueous polymer dispersion is mixed with 40%solution of the active substance and tetrahydrofuran by means of two pumps in the mixing device through the mixing nozzle. The consumption of polymer dispersion is 12 kg/h, the flow rate of solution of tetrahydrofuran is 3 kg/h, so the total flow rate is 15 kg/h of the Mixing device comparable to the one described in the publication "Handbook of Industrial Crystallization" (A.S.Myerson, 1993 Butterworth-Heinemann, page 139, ISBN 0-7506-9155-7) apparatus. Get light yellow milky suspension with 8% of the active substance and 24% of the polymer. Then the tetrahydrofuran and water are removed, so that the produced water composition with a particle size in nm with 10% active ingredient and 30% polymer.

II.3 Example compositions 1: solubilisation pyraclostrobin by the method of phase inversion (General methods, see 2).

10 g pyraclostrobin dissolved together with 30 g of the amphiphilic polymer composition from example 2 in 100 g of tetrahydrofuran. Then with stirring, add water and remove the tetrahydrofuran under reduced pressure. The amount of water is chosen so that the resulting aqueous composition comprises 10 wt.% active ingredient and 30 wt.% amphiphilic polymeric composition.

The resulting composition of the active substance was homogeneous, almost visually transparent in at least a few months stable to sedimentation and could be diluted with water fully desalinated water and water 10°pH), without the occurrence of sedimentation or crystallization of the active substance. The dispersed phase (particles of polymer/active substance) had a spherical structure and an average diameter, determined by the scattering, approx. 30 nm.

II.4 Example compositions of 2: solubilisation pyraclostrobin according to the method of solubilisate (General methods 1).

Pyraclostrobin is at 70°C well-flowing liquid (viscosity of 2200 MPa·s) and shall be made in the composition according to 1 at a temperature of 70°C. the resulting composition of the active substance was homogeneous, almost visually transparent, stable to sedimentation of at least a few months and could be diluted with water fully desalinated water and water 10°pH), without the occurrence of sedimentation or crystallization of the active substance.

The dispersed phase (particles of polymer/active substance) had a spherical structure and an average diameter, determined by the scattering, approx. 30 nm.

II.5 Example compositions 3: solubilisation pyraclostrobin method dose sedimentation (General admission 4).

Pyraclostrobin translated into a composition in accordance with the General admission 4. The resulting composition of active substances which were homogeneous, almost visually transparent, stable to sedimentation of at least a few months and could be diluted with water fully desalinated water and water 10°pH), without the occurrence of sedimentation or crystallization of the active substance

II.6 Example compositions of 4: solubilisation of metconazole method of phase inversion (General admission 2).

10 g of metconazole, solid substance with a melting point of from 110 to 113°C, diluted with 30 g lifeflow polymer composition of example 1 in 100 g of tetrahydrofuran. Then with stirring, add water. Remove the tetrahydrofuran under reduced pressure. The amount of water is chosen so that the resulting composition contains 10 wt.% active ingredient and 30 wt.% amphiphilic polymeric composition.

The resulting composition of the active substance was homogeneous, almost visually transparent, stable to sedimentation of at least a few months and could be diluted with water fully desalinated water and water 10°pH), without the occurrence of sedimentation or crystallization of the active substance. The dispersed phase (particles of polymer/active substance) had a spherical structure and an average diameter, determined by the scattering, approx. 30 nm.

Similarly can be obtained, and others, are presented in table 1 compositions dei is adequate substances.

II.7 Example compositions of 5: solubilisation acetate vitamin a by the method of phase inversion (General admission 2).

10 g of the acetate of vitamin a together with 30 g of the amphiphilic polymer composition from example 2 are dissolved in 100 g of tetrahydrofuran. Then, under stirring, water is added and removed under reduced pressure tetrahydrofuran. The amount of water is chosen so that the resulting composition contains 10 wt.% active ingredient and 30 wt.% amphiphilic polymeric composition.

The resulting composition of the active substance was homogeneous, almost visually transparent, stable to sedimentation of at least a few months and could be diluted with water fully desalinated water, so the water 10°pH), without the occurrence of sedimentation or crystallization of the active substance.

III Technical tests.

III. 1 Checking fungicidal activity.

The aqueous composition of the active substance from the example compositions 1 compared with two commercially purchased music of the same active substance pyraclostrobin regarding their activity against Phytophthora infestans on tomatoes in the greenhouse according to the following methods (preventive experiment, projective activity):

The composition of the active substance is diluted with tap water to the desired concentration (between 4 and 250 mln). Use on tomatoes is carried out in the chamber for spraying a volume of 25 ml, which corresponds to the usual practice on the amount of water approx. 500 l/ha Pathogenic fungus (Phytophthora infestans) inoculant 7 days after treatment. Plants placed in a greenhouse at 18 to 20°C and 90% relative humidity. 5 days after inoculation determine the percentage defeat leaves.

The biological results of the experiment are presented in table 2. The results show that the stabilized polymer particles of the active substance has fungicidal activity at the level of commercially purchased products.

1) EU-composition:

23.5 wt.% pyraclostrobin,

4.7 wt.% anionic wetting agent and

4.7 wt.% neaning of wetting

67,1% wt. inorganic solvent.

1. Amphiphilic polymer composition used in the compositions of active substances for plant protection or in the compositions of additives to food products interaction
a) at least one hydrophobic polymer P1, which is reactive towards isocyanate groups of the functional g is PI R ^P1and which is made of ethanobotany monomers M1, including:
A1) from 50 to 99 wt.%, in terms of the total amount of monomers M1, of monomers MA General formula I

where X is oxygen;
R¹means C₁-C₁₀-alkyl, C₅-C₁₀-cycloalkyl, phenyl or phenyl-C₁-C₄-alkyl;
R²means hydrogen or C₁-C₄-alkyl; and
R³means hydrogen;
A2) from 1 to 50 wt.%, in terms of the total amount of monomers M1, neutral monomethylethanolamine monomers M1b, the water-solubility of which at 25°C. is less than 50 g/l and which are different from monomers MA; and selected from vinylaromatic monomers, With₁₁-C₂₀alkylacrylate and C₁₁-C₂₀the alkyl methacrylates,
b) at least one hydrophilic polymer P2, which is reactive towards isocyanate groups of the groups R^P2and which is a simple aliphatic polyesters comprising at least 50 wt.% from ethylenoxide groups,
c) with at least one containing the isocyanate group of compound V, which has isocyanate groups functionality from 1.5 to 4.5, and is selected from aliphatic, cycloaliphatic and aromatic di - and polyisocyanates, as well as from isocyanurates, al is ofunato, uretdione and Burlov,
moreover, the proportion of hydrophobic polymer P1 in the amphiphilic polymer composition is from 20 to 68 wt.%, the proportion of hydrophilic polymer P2 in the amphiphilic polymer composition is from 30 to 78 wt.%, and the proportion of the compound V in the amphiphilic polymer composition is from 2 to 20 wt.%, each time calculated on the total weight of polymer P1 and polymer P2 and connections V.

2. Polymer composition according to claim 1, where the hydrophobic polymer has functional groups R^P1the functionality of F1 in the range from 0.5 to 1.5.

3. Polymer composition according to one of the preceding paragraphs, where the hydrophobic polymer P1 has srednesemennyh molecular weight in the range from 500 to 20000 Da.

4. Polymer composition according to one of the preceding claims 1 or 2, where the hydrophilic polymer has no ionic groups.

5. Polymer composition according to claim 4, where the hydrophilic polymer P2 is a simple aliphatic polyester, which is at least 70 wt.% made of ethyleneoxide groups.

6. Polymer composition according to one of claims 1 or 2, where the hydrophilic polymer P2 relative to the functional groups R^P2has the functionality of F2 in the range of from 0.5 to 3.0.

7. Polymer composition according to one of claims 1 or 2, where the hydrophilic polymer P2 has srednesemennyh molecular weight in the range from 500 to 20000 Da.

8. Polymer is the song in one of claims 1 or 2, where the hydrophobic polymer P1 and the hydrophilic polymer P2 is applied in a weight ratio of P1:P2 in the range of from 1:10 to 10:1.

9. The way to obtain amphiphilic polymer composition according to one of the preceding paragraphs, including interaction
i) at least one hydrophobic polymer P1, which is made of ethanobotany monomers M1 and is reactive towards isocyanate groups, a functional group R^P1and
ii) at least one hydrophilic polymer P2, which is reactive towards isocyanate groups, a functional group R^P2,
iii) at least one containing functional group of compound V, which has isocyanate group functionality of at least 1,5.

10. The method according to claim 9, where the polymer P1 and polymer P2 is subjected to interaction with connection V series.

11. The method according to claim 9, where the polymer P1 and polymer P2 is subjected to interaction with compound V in one step.

12. The use of amphiphilic polymer composition according to one of claims 1 and 2 for stabilization in the aquatic environment of existing substances that have a solubility in water at 25°C./1013 mbar below 10 g/l, and the active substance is a substance for plant protection or additive to food products.

13. The use of amphiphilic polymer composition of the resultant of claims 1 and 2 to obtain the compositions of active substances, which have a solubility in water at 25°C./1013 mbar below 10 g/l, and the active substance is a substance for plant protection or additive to food products.

14. The use of amphiphilic polymer composition according to one of claims 1 and 2 to obtain the aqueous compositions of active ingredients which have a solubility in water at 25°C./1013 mbar below 10 g/l, and the active substance is a substance for plant protection or additive to food products.

15. The composition of the active substance for plant protection or additives to food products, comprising at least one active ingredient which has a solubility in water at 25°C./1013 mbar below 10 g/l and at least one amphiphilic polymer composition according to one of claims 1 and 2, and the active substance is a substance for plant protection or additives for food products.

16. The composition of the active substance according to item 15, containing the active substance and the amphiphilic polymer composition in a weight ratio of from 1:10 to 3:1.

17. The composition of the active substance in one of p or 16 with a content of volatile organic compounds is less than 10 wt.%, in terms of the total weight of the composition.

18. The water composition of the active substance for plant protection or additives to food products comprising water as a continuous phase and at least, one is the dispersed phase, containing at least one active ingredient which has a solubility in water at 25°C./1013 mbar below 10 g/l, and at least one amphiphilic polymer composition according to one of claims 1 and 2, and the active substance is a substance for plant protection or additives for food products.

19. The composition of the active substance on p, and disperse particles have an average size determined using dynamic light scattering, of not more than 300 nm.

20. The composition of the active substance on p or 19, containing the active substance and the amphiphilic polymer composition in a weight ratio of from 1:10 to 3:1.

21. The composition of the active substance on p with volatile organic compounds is less than 10 wt.%, in terms of the total weight of the composition.

22. The method of obtaining the composition of the active substance in one of PP or 18, including the production of homogeneous, non-aqueous mixture comprising amphiphilic polymer composition and at least one active substance.

23. The method of obtaining water composition of the active substance on p, including:
a) obtaining a homogeneous, non-aqueous mixture consisting of amphiphilic polymer compositions and active agent, and
b) dispergirovanija thus obtained mixture with water.

24. The method of obtaining water compositions dejstvuusih the substances on p, including:
a) obtaining a solution of the active substance and, if necessary, amphiphilic polymer composition in an organic solvent which has a boiling point lower than water, and
b) mixing the solution of the active substance with water or an aqueous solution of amphiphilic polymer and
c) removing the organic solvent.

25. The method of obtaining water composition of the active substance on p, including vrabatyvanie active substance in an aqueous solution of amphiphilic polymeric composition at a temperature above the melting temperature of the active substance.