Method of integrated treatment of spinal osteomyelitis with applying regional lymphotropic therapy |
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IPC classes for russian patent Method of integrated treatment of spinal osteomyelitis with applying regional lymphotropic therapy (RU 2372077):
 Polymorphic modification of a ibandronate / 2368617
Invention relates to a new crystalline polymorphic modification of a monohydrate of mon-sodium salt of 3-(N-methyl-N-pentyl)amino-1-hydroxypropane-1,1-diphosphonic acid (ibandronate) of formula 1, used for controlling hypercalcemia.
 Pharmaceutical products containing biphosphonates / 2358739
There is disclosed pharmaceutical product as prepared solution. The pharmaceutical product comprises a reservoir filled with dissolved zoledronic acid or its pharmaceutically acceptable salt. At least the internal surface of said reservoir contains plastic material that is polyolefin. The product is exposed to thermal sterilisation, preferentially to moist thermal sterilisation. Besides the product can contain a buffer component, preferentially the buffer organic base. Additionally, the product can contain an isotonic component, preferentially mannitol. The invention provides product sterilisation at high temperature 121°C during 150 minutes without visible deformations and damages of sealed integral reservoir, as well as decomposition of pharmaceutical substance.
 Bone loss treatment and prevention method / 2358728
Compound contacts with 15-lipoxygenase and tested for activity for 15-lipoxygenase inhibition.
 Method of aseptic whirlbone necrosis and perthers disease treatment / 2357736
Invention concerns medicine, particularly orthopedics and extracorporal treatment methods, and can be applied in aseptic whirlbone necrosis and Perther disease treatment. Method involves venous blood sampling in amount of 300 ml with further blood separation into erythrocyte mass and plasma. Obtained erythrocyte mass is diluted by 200 ml of 0.9% physiological solution and administered intravenously to patient. 100 ml or patient's plasma is placed in thermostat and incubated for 20 minutes at 37°C. Further 20 mg of vasoprostan medicine is added to incubated plasma, and obtained mix is administered to patient by drop infusion for 1.5-2 hours once a day for 10 days.
Method of prevention of postoperative osteomyelitis / 2343925
For prevention of postoperative osteomyelitis use composition consisting of antimicrobial substances, dissolved in high-molecular polyvinylpyrolidone with molecular mass of 1 million. The composition is administered using a syringe into the medullar channel and in the intermuscular spaces surrounding a bone, on a measure of sealing of soft tissues after operation. Invention allows to give antimicrobial activity to tissues surrounding wound for long time at the expense of slow biodegradation of polyvinylpyrolidone and long-term diffusion of antimicrobial substances from a composition in a tissue.
 Amorphous alendronate monosodium, methods of production, based pharmaceutical composition and method of inhibition of bone resobrtion / 2334751
Invention refers to method of production of amorphous alendronate monosodium and to solid pharmaceutical composition having property to invoke bone bulk expansion and containing therapeutically effective amount of amorphous alendronate monosodium, produced by stated method. Method of production of amorphous alendronate monosodium includes solvent removal from alendronate monosodium solution using spray drying.
 Pharmaceutical formulation applied for prevention and treatment of bone tissue resorption of any etiology, transdermal delivery and treatment technique / 2325165
Given invention refers to pharmaceutical field, specifically to pharmaceutical formulation of gel dosage form applied for prevention and treatment of osteoporosis including as an active component bisphosphonate incorporated in phospholipid vesicles generated from lipid and hydrophilic phases, including components in the following proportions, mass %: bisphosphonate 0.01-2.0; egg lecithin 1.0-6.0; pine essence 0.05-0.2; camphor oil 0.01-1.0; olive oil 0.01-5.0; vitamin E 0.01-0.15; vitamin D 0.01-0.2; vitamin F 0.2-0.4; carbopole 0.4-0.6; NaOH 0.42; glycerol 2.0-4.0; nipagine 0.3; nypazole 0.1; water and others. In addition invention refers to treatment of bone tissue resorption of any etiology and osteoporosis for patients suffering from gastrointestinal disturbance with this composition.
 Osteoprotegrin, its application for preparation of pharmaceutical composition (variants), production of food substance (variants) and fodder, food substance, fodder and pharmaceutical composition for prevention and treatment of disorders related to bone remodeling, and/or immune disorders / 2324705
This invention is related to biotechnology, to be more precise, to preparation of proteins out of milk, and may be used for prevention or treatment disorders related to metabolism in bones and immune function. Osteoprotegrin is prepared out of human or cow milk and has glycolysis profile that produces polypeptide with molecular mass of approximately 80, 130 and 200 kilodaltons. Prepared protein is used in structure of food substance and pharmaceutical composition for prevention or treatment of disorders related with bone remodeling, and/or immune disorders. Also prepared protein is added to make fodder.
 Method for treating and preventing the loss of bony tissue / 2319483
The present innovation deals with treating and preventing the loss of bony tissue and/or increased development of bony tissue. For this purpose it is necessary to apply 15-lipoxygenase inhibitors. These molecules could be introduced either individually or in combination with agents that inhibit the resorption of bony tissue or additional agents that regulate calcium resorption out of bony tissue or increase the accumulation of bony tissue. The innovation enables to widen the assortment of medicinal preparations for treating diseases associated with the loss of bony tissue, such as osteoporosis, osteoarthritis, Paget's disease and those of periodontium and, also, the fractures.
Osteoplastic composite material / 2307661
Material comprises deproteinized allobone granules as filler, the granules being at least 1 mm large, and hydrophylic dimethylacrylate as monomer. Bone cement, filler and monomer are taken in 1:1:0.5 proportion, respectively.
 Method of post cosmetic surgery rehabilitation / 2366413
Invention refers to medicine and can be used for post cosmetic surgery rehabilitation that is ensured by introduction of mixed medicinal preparations in lymphoid region of orbit, namely within pterygopalatine fossa and parotid. The mixed preparations introduced in pterygopalatine fossa are lidocaine 50-100 mg, dexamethasone 4-8 mg, glucose 400-800 mg, dalargin 1-2 mg and Lydasa 16-32 UN. And parotid injection contains lidocaine 50-100 mg, aminophylline 24-28 mg, hystochrom 10-20 mg and Lydasa 16-32 UN. Introduction of the mixed preparations is carried out on right or left side of face alternately every 4-5 hours daily within the course 6-8 procedures. Then 3-5 procedures of discrete plasmapheresis follow with using no more than 20-25% of total blood volume for exfusion. The prepared cell mass is incubated with 250-350 cm3 of ozone-oxygen mixture of ozone concentration 3000-3200 mkg/l.
Method of adhesion therapy following thoracic and abdominal organs surgery / 2348415
Adhesion therapy following thoracic and abdominal organs surgery is ensured with multiple daily applications of Tizol gel and salicylic acid mixed as: salicylic acid 0.2 g and Tizol gel to 10 g, thus coating incision cicatrix and skin, adjacent anterior abdominal wall or thorax part over lesion focus. Thereafter within three months, multiple daily applications of medicinal composition containing Tizol gel and Lidase mixed as: Lidase 128 st.units per Tizol gel 10 g are used for the indicated regions. Herewith three physiotherapeutic procedures are performed every two weeks as follows: either phonophoresis, or electrophonophoresis, or electrodreging with the specified composition containing Tizol gel and Lidase.
Method for increase of stem cells reserve in organism / 2347583
Hyaluronidase is injected into laboratory animals (mice) intraperitoneally in amount of 1000 CU/kg 1 time per day, for 2 days.
Method of peripheral nerve damage treatment / 2337725
Neurolysis, autoneuroplasty of nerve defect are carried out from 2-3th day after direct electrostimulation operation of proximal end of injured nerve, zones of neuroraffia and autoneurotransplant by electroneuromyography (ENMG) results. Additionally, medical products vitamins B1 and/or B12, and/or C, and/or Berliotin and spasmolytics are introduced. ENMG is applied for area above plastics zone and if in 2-3 weeks there is no evoked potential response, neuroma is excised or reautoneurotransplantation is applied. Following direct electrostimulation is accompanied with introduction of medical products: growth-promoting agents and spasmolytics; electrophoresis with iodine and/or lidase. If after that in 3-4 weeks evoked potentials are recorded to be frequency and amplitude, in addition transcutaneous electrostimulation of enervated muscles combined with introduction of lidase, anticholinesterase agents and spasmolytics. After implanted electrodes are removed, transcutaneous electrostimulation is applied from proximal end of nerve to innervated muscle zones within 5-7 days. If evoked response is not recorded, cicatrical adhesive tissue is excised in area of enervated muscles and/or neurotransplant bed combined with introduction of lidase. Direct electrostimulation of plastics zone and enervated muscles is repeated till evoked response is recorded, then transcutaneous electrostimulation of restored muscles is applied combined with introduction of anticholinesterase agents within 4-6 weeks. However if 1-2 weeks after muscular response to stimulation is not recorded, automyoplastics is applied.
 Method of intensification of stem cells mobilisation / 2330674
In case of extreme affections or pathological conditions accompanied by stem cells mobilisation, or in case of exposure of stem cell functional activity modifiers causing stem cells mobilisation, hyaluronidase is injected intraperitoneally in dose 500-1500 CU/kg within 2 days once a day.
Method of wound healing / 2326657
For this purpose wound area is locally oxygenated by means of subcutaneous paravulnar injection of oxygenic perfluoran. Perfluoran is dosed 0.1-0.5 ml per 1 kg of body weight, daily until oedema comes off. Besides 5 minutes before perfluoran introduction lidasa dosed 16-32 units is subcutaneous introduced. And 10 minutes after perfluoran introduction contrast bathes are taken during 10-15 minutes.
Method for prophylaxis of relapse lithiasis / 2320368
Method involves administration of hyaluronidase conjugate (lydazum) with activated derivative of poly-1,4-ethylenepiperazine N-oxide (analog of polyoxidonium) in a single dose 3000 IU by intramuscular route, 3 days before of operative removal of concrements. After removal of concrements the drug is administrated in indicated dose by the following schedule - once for 3 days, 5 injections, then once for 5 days, 15 injections, then once for 10 days, 15 injections. Proposed invention provides improvement and normalization of physicochemical and biochemical indices of urine that promotes to decreasing of relapse lithiasis.
 Method for treating acute posttraumatic cephalgia cases / 2317805
Method involves administering traditional combined therapy including vasoactive resorbing therapy, introducing nootropic agents, vitamins, biostimulators, therapeutic physical training, physiotherapy and massage. 3-4 procedures of subaponeurotic introduction of 1.5-2.0 ml of are additionally given in mastoid cranial process base region. The procedure is carried out once a day and repeated every other day.
Method for applying regional lymphotropic therapy in treating patients for acute pleural empyema / 2312659
Method involves subcutaneously slowly introducing mixture containing 2% lidocaine solution 0.5 ml, lydase 64 AU and Cephotaxime 1 ml available in single syringe. A half of syringe contents is subxiphoidally introduced and the other half into VIII intercostal space along middle axillary line on pathological process side. One injection is given once a day during 5 days and pleural sack is concurrently drained.
Method for reconstructing the function of regional lymph nodes / 2310470
The present innovation deals with treating patients with lymphatic insufficiency of inferior limbs: lymphedema of inferior limbs, post-thrombophlebitis syndrome, syndrome of diabetic foot, synovites of different etiology, etc. One should fulfill combined introduction of the mixtures of medicinal preparations. Moreover, one mixture consisted of 32 U lidase, 4 ml anecaine, 4 mg dexametason, 1 ml alflutop should be introduced into Hoff's adipose body. Another mixture consisted of 32 U lidase, 80 mg actovegin, 4 ml anecaine should be introduced along anterior-median surface of the upper femoral third, in projection of surface lymph vessels and lymph nodes. The procedure should be carried out at 48-h-long interval. The innovation enables to interrupt congested phenomena in inferior limbs due to improving the lymph outflow and reconstructing the function of regional lymph nodes.
 Method of respiratory disease treatment of young stock / 2367414
Invention relates to veterinary science. The method includes intramuscular injection of dioxygen. Dioxygen is injected as follows: two times every day in the dosage of 0.1 ml/kg of body weight within 5-7 days, in case of complicated course of a disease - within 7-9 days.
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FIELD: medicine. SUBSTANCE: invention concerns medicine, namely traumatology, orthopaedics and can be used for treatment of spinal osteomyelitis. That is ensured by antibacterial, immunocorrective, detoxication therapy, and surgical sanation and resection of the inflammation centre, and autogenous bone grafting of the cavity, and stabilisation with a plate of the system AESCULAP "MACS". It is combined with regional lymphotropic therapy according to the schedule dry Lydasa 64 st. units, 2% lidocaine 2 ml, lincomycin 2 ml. The mixture is introduced every 48 hours in number of 5 injections in the preoperative period and 7 injections in the postoperative period. EFFECT: such method of spinal stabilisation in combination with the developed schedule of regional lymphotropic therapies provides higher stability in injured spinal locomotive segment and prevention of inflammatory complications before surgical sanation of the centre. 1 ex
The invention relates to medicine, specifically to traumatology, orthopedics, and can be used in treatment of osteomyelitis of the spine. Hematogenous osteomyelitis of the spine is referred to polietiologic seriously leaking, difficult to diagnose diseases, is difficult to forecast. Treatment involves surgical rehabilitation, antibacterial therapy, immunocorrection, detoxification. When osteomyelitis of the spine is often the source of infection is located in craniodental Department vertebra, closed anterior longitudinal ligament, where the microorganisms are in the final parts of the vascular arcades adjacent to the subchondral plate. The pathogen penetrates into the vertebra by vascular messages, usually hematogenous route. In the literature there is consensus that a holistic therapy. Known integrated method of treatment with antimicrobial therapy, immune therapy, detoxification therapy and porous titanium nickelide Ni Ti as a replacement cavity in the surgical rehabilitation of the hearth with the fixation of antibiotics in porous implants. This method is applicable to all implants with a through porosity. The basis of fixation of drugs is soaking the implant with a solution of the antibiotic liquid gel, pic is e which when cooled to room temperature, the gel solidifies. After heating changes its phase state, and the antibiotic starts to escape. Antibacterial activity of gelatin gel, and the implant, respectively, is stored in 2 weeks, which is especially important in surgical treatment of purulent processes. (Described in candles. Diss. Ayusawa, 2006, performed at the Department of traumatology, orthopedics and field surgery of the State educational institution of Higher professional education of the Tyumen state medical Academy: "Diagnosis and surgical treatment of osteomyelitis of the spine"). The method has the following disadvantages: Fixing antibiotic in porous implant requires special equipment and sterile laboratory conditions. Placed the implant of porous Ni-Ti in the cavity formed in the process of surgical rehabilitation, have a greater risk of sepsis in the postoperative period, since there is no guarantee that the hearth is completely free of pathological microorganisms, and the presence of metal in the cavity may exacerbate the process. In addition, in the hearth, where impaired circulation and lymph circulation, the germination process of bone into the porous implant will be significantly slowed down. This, in turn, leads to micromovement (instability) between the bone surface and a porous implant, which in its turn is can cause dislocation (displacement) of the implant with the loss of strength (support ability) in the affected vertebral motor segment, and orthopedic complications, and also to the phenomenon of metallosis and exacerbation of the inflammatory process. Used porous implants do not have the property "to be reborn" in bone formation bone block, i.e. biodegradable properties. Well-known, conventional method of treatment of osteomyelitis of the spine, which includes antibiotic therapy, immunokorrigiruyuschuyu therapy, detoxification and surgical rehabilitation of inflammation. This method is described in the works (Batroc, Y.M., V. Zaitseva. Peculiarities of diagnosis and treatment of acute hematogenous osteomyelitis of the spine. Surgical aspects of the trauma of the spine and spinal cord // Novokuznetsk, 1997, S-188; Zivian AL Hematogenous osteomyelitis of the spine // journal of surgery. Grekov, 1965, No. 6, C.116-120; Ardashev I.P., Goryachev A.N., Grigoruk A.A., SH.M. Musayev. Osteomyelitis of the spine // Kemerovo, 2001). With this method of treatment, the introduction of antibiotics produced by intravenous or intramuscular manipulation, taking into account the sensitivity of microflora that requires the constant support of high dosages of antibiotics and, accordingly, the concentration of drug in the blood, for the impact on hard-to-reach site of infection both before and after surgical rehabilitation of the hearth. This treatment does not provide full anti-inflammatory what about the effect since the introduction of antimicrobial drugs is limited to those regions, where the functioning of the circulatory system, i.e. the body of the vertebrae, and does not affect diseased discs, system stimulation extravascular humoral transport, lymphatic drainage and detoxification of tissue fluid and lymph. In addition, surgical sanitation limited resection of the nidus, after which the formed groove (cavity) is filled with autobone, taken from the iliac crest or the tibial tuberosity, without stabilize some form of instrumentation. This, in turn, is a prerequisite for the kyphotic deformity in the process of formation of a bone block in a sanitized the hearth, as autograft implanted in the formation of bone block loses its strength (support function), which leads to orthopedic complications and longer protective regime of the patient. Known plate AESCULAP "MACS" for ventral (anterior) stabilization of the spine (www.Aesculap.de), which is used as thoracic and lumbar spine. The objective of the invention is to increase stability in the affected vertebral motor segment and prevention of inflammatory complications before and after surgical rehabilitation of the hearth. Fasting is certain the task is solved by in the method of complex treatment of osteomyelitis of the spine, including antibacterial therapy, immunokorrigiruyuschuyu therapy, detoxification and surgical rehabilitation with resection of inflammation with subsequent substitution of the cavity autobone, surgical rehabilitation of inflammation replace the cavity autobone with subsequent stabilization plate system AESCULAP "MACS", produce regional lymphotropic therapy before and after surgical rehabilitation of the hearth according to the scheme: 64 UE dry lidz dissolved in 2 ml of 2% lidocaine solution, and then this mixture was added 2 ml of lincomycin, the mixture is injected every 48 hours at 5 injections in the preoperative period and 7 injection in postoperative periods. When immunokorrigirujushchej therapy produce intravenous antistaphylococcal plasma is not less than 400 ml. Detoksicazionnaya therapy includes solutions ringer, reopolyglukin, polyglycine, saline with vitamins b and C. Antibiotic therapy involves intravenous introduced introduction cephalosporins II-III generation. Regional lymphotropic therapy in the preoperative period and the postoperative periods is as follows: in terms of pure dressing, before manipulation to prepare a comprehensive drug mixture: 64 UE su is th lidz dissolved in 2 ml of 2% lidocaine solution, then to this mixture was added 2 ml of lincomycin, which has the greatest trapnest to the bone. Then cleansed with an antiseptic solution twice treated field, where there will be manipulation. Places of introduction is Marostica ligament above and below the affected vertebral motor segment, i.e. in those regions where there is no violation of lymph and blood circulation. Needle injected into megastate a bunch at a depth of 1 cm, the Mixture is injected every 48 hours at 5 injections in the preoperative period and 7 injections in the postoperative periods. Surgical reorganization carried out by standard methods, followed by resection (removal) of the nidus within healthy tissue. The resulting cavity is filled with autobone, previously taken from the iliac crest. Above and below produced bone grafting produce the structure mounting plate with screws (AESCULAP "MACS"), and the screws inserted into the body above and underlying vertebrae, thus achieving stability in the segment, i.e. the absence of micromotion, dislocation (displacement) of the implanted autoceste and subsequent kyphotic deformity. Clinical example 1. Lady patient, 39 years turned to a specialist and orthopaedic hospital and was hospitalized in a planned manner in traumato logicheskie Department 10.05.06 with complaints of pain in the lumbar spine with irradiation to the legs under load and at rest and a temperature of 37-38°C. From the anamnesis: one month prior to hospitalization was the period of hypothermia, then came the pain in the lumbar spine with increasing temperature up to 38 degrees. In January 2006 was conducted on the treatment of caries of the teeth by a dentist within 4 weeks. Received conservative treatment for back pain in RSD on a residence diagnosed with osteochondrosis. No improvement was noted, the pain intensified, appeared radiating pain in the legs, the temperature remained low. Examination: palpation in the area of the spinous processes of L2-L3-L4 vertebrae marked tenderness, the voltage of the paravertebral muscles, movement sharply limited and painful. Violations of sensitivity and pulsation in the lower extremities no. With minimal strain was any pain in the lumbar spine with irradiation to the legs. On spondyliosoma destruction tel L2-L3 vertebrae, reducing the height of the disk L2-L3 vertebrae, the tendency of the kyphotic deformity. On MRI examination revealed inflammatory changes in the segment L2-L3, MP - signs of dissita, epicuria. Diagnosis: Acute hematogenous osteomyelitis of the lumbar spine. Destruction tel L2-L3 vertebrae. Toxic-adinamicheskoy form. Pain and radicular syndrome. The treatment according to the scheme, which included Antibacterials the Yu therapy intravenous - detoxification therapy, immunokorrigiruyuschuyu therapy, surgical revision of inflammation with autoplastic and stabilization plate system AESCULAP "MACS", as well as regional lymphotropic therapy for 5 injections in the preoperative period and 7 injections in the postoperative period. As a result of treatment after 4 weeks, the patient of inflammation in the affected segment of the spine cropped, the segment is stable. The patient on the 10th day after the operation goes to the corset. Complaints of pain in the lumbar spine with irradiation in feet no. The analysis of the phenomena of inflammation there. The patient was discharged from the hospital with improvement. At the control examination after 3 months after discharge, the results of treatment saved. The method of complex treatment of osteomyelitis of the spine, including antibacterial therapy, immunokorrigiruyuschuyu therapy, detoxification and surgical rehabilitation with resection of inflammation with subsequent substitution of the cavity autobone, characterized in that in the surgical rehabilitation of inflammation replace the cavity autobone with subsequent stabilization plate system AESCULAP "MACS", produce regional lymphotropic therapy before and after surgical rehabilitation focus, according to the scheme: 64 UE dry lidz dissolved in 2 ml of 2% solution of lead is Cain, then to this mixture was added 2 ml of lincomycin, the mixture is injected every 48 h in an amount of 5 injections in the preoperative period and 7 injections in the postoperative period.
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