Treatment of patients suffering from exogenic constitutive obesity |
|
|
IPC classes for russian patent Treatment of patients suffering from exogenic constitutive obesity (RU 2356529):
Method of obesity treatment / 2354360
Invention relates to medicine, in particular to endocrinology, and concerns obesity treatment. For this purpose patient suffering from obesity is introduced thioctacide in dose 600 mg daily intravenously by dripping in isotonic solution 10 times. Then said preparation is introduced in tablets in dose 600 mg in the morning 30 minutes before breakfast during 1-2 months. Treatment is carried out against the background of hypocaloric diet.
Application of local anesthetic for correction of alimentary behaviour of person and method of application / 2352332
Group of inventions concerns medicine and providing restriction of food intake is intended for correction of alimentary behaviour of the person. For this purpose it is suggested to use local anaesthetic. The method of correction includes preliminary psychological preparation, instructing of the person, discontinuing of process of food intake in the moment which define individual restriction of quantity of used nutrition and introduction of orally effective quantity of local anaesthetic.
 Application of oxyntomodulin, method and pharmaceutical composition for prevention or treatment of excessive body weight / 2351359
Invention relates to medications and concerns application of oxyntomodulin or its analogue, in which histidine residue in position 1 is preserved or substituted with other aromatic amino acid carrying positive charge, or its pharmaceutically acceptable salt or conjugate with polymer or polysaccharide or chemically modified version, in particular, by means of modification of side chains, C-end, acidifying and amidating, for prevention or treatment of excessive body weight in mammals. Also described are pharmaceutical compositions and methods applied for prevention or treatment of excessive body weight in mammals.
Ve agaphonov's method of correction and optimisation of patients nutrition for improvement of organism and excess weight depression / 2350339
Invention concerns medicine, namely to dietology and immunology, and can be used for organism improvement. The way includes definition of the maintenance of immunoglobulins of subclass IgG4-antitsl, a specific foodstuff to antigens in blood serum of the patient. At indicators above 7 mkg/ml, these products are excluded from food allowance. Products causing IgE-mediated hypersensitivity of 1 type from food allowance are also excluded. After that a daily food allowance of other products is made for the patient from references to use not more than 2-3 names of foodstuff per one time at their daily alternating.
 Compounds causing weight loss / 2350327
Present invention relates to the area of medical products, in particular to the weight loss compound, containing an opioid antagonist naltrexone and bupropione in synergistic effective quantities. The way of weight reduction is besides, described at introduction: naltrexone and bupropione or fluoxetine; or nalmephene and fluvoxamine. Also the invention concerns application of the specified combinations for preparation of medicinal agents for weight reduction.
Method of treatment of excess body weight by means of reflexotherapy (filleropuncture) / 2350309
Invention relates to medicine, in particular - to reflexotherapy. The way includes influence on acupuncture points GI 14, AT 17, AT 18, E 25, E 19. Influence is performed by introduction of the filler by means of a needle and a syringe. In each AT 17, AT 18 inject the filler subcutaneously or intradermally in amount of 0.1-0.2 ml. Inject the filler Into point G1 14(2) in number of 0.1-0.4 ml on depth of 10 mm. In acupuncture points E25(2), 19(2) the filler is injected in amount of 0.1-0.4 ml, and in the point E25 the filler is injected on depth of 15-20 mm, and into the point E 19 - on depth of 15 mm.
 Nutrition additive and foodstuff containing potato painted in purple colour for patients, suffering from adiposity (versions) / 2350120
Invention concerns healthy and functional nutrition. The additive to the nutrition, possessing activity of adiposity suppression, represents an extract of the potato painted in purple colour - Solatium tuberosum L., cv. Bora valley. The additive is entered into structure of various foodstuff.
 Compounds for metabolic disorder treatment / 2349584
Invention claims bioactive agent in the form of compound of formula (I)
 Derivatives of 2-acylamino-4-phenylthiazol, their obtainment and application in therapy / 2348630
Compounds of the invention have chemokine antagonistic properties and can be applied in treatment of immunoinflammatory diseases, such as atherosclerosis, allergy diseases. In general formula (I)
 Fat content control / 2346688
Fat content control in the organism is ensured by stabilisation of alpha subunit of hypoxia induced factor protein (HIFα). To stabilise HIFα, effective amount of compound, inhibiting HIF hydroxylase activity, is introduced.
Method of treating secondary immunodeficiency in children in post-operative period in case of severe craniocerebral injury, combined with injuries of musculo-sckeletal system / 2355419
For treatment of traumatological and neurosurgical diseases ceruloplasmin is included in treatment scheme. Single daily introduced dose is 6-8 mg/kg, depending on child's age, per 200 ml of 0.9% of sodium chloride solution. Medication is introduced by intravenous drip at rate 20-25 drops a minute for not less than 12 days.
Treatment of patients suffering from gonarthrosis associated with lower limb edema syndrome / 2353408
Invention refers to medicine, namely to physiotherapy. Treatment mode includes physiotherapy combined with nonsteroid antiinflammatory pharmacotherapy. The patient while lying on back is exposed to pulse magnetotherapy within a projection of anterior knee joint within 10 minutes. Then the action contrast temperatures and low-frequency ultrasound are combined with injection of protein-degrading enzyme Chymopsinum into a projection of superior torsion of knee joint. The course includes 10 procedures.
 Method of treatment of clottage of central vienna of retina / 2352304
Invention concerns ophthalmology and is intended for treatment of patients with clottage of central vein of retina. Subtotal vitrectomy is spent. After excision of a vitreous body, the vitreous cavity is filled with air, entering a solution of the recombinant prourokinase on the retina in a projection of an optic disk in the amount of 0.5 ml 1500-2000 ME for 15-20 minutes then the rest of the preparation is washed away. After that the handpiece of the vitreotome is established over an optic disk and, in an aspiration regimen, at value of vacuum of 200-300 mm hg within 1 minute the gradient of pressure in the field of a trellised plate is alternately framed. Then again the vitreal cavity is filled with air and the recombinant prourokinase in the same volume 500-1000 ME is repeatedly entered, and the patient is located in a prone position for 2 hours.
Wound dressing / 2349348
Invention concerns medicine, particularly media of surfacial wound and burn treatment, and can be applied in surgery, traumatology, therapy, ophthalmology, veterinary and adjoining fields. Wound healing medium is superexpanding polymer matrix including collagenase in amount of 1-10 wt % of matrix weight. Superexpanding polymer matrix is a matrix obtained by copolymerisation of at least two monomers of group including maleic, crotonic and acrylic acids and/or their derivatives in the presence of binding agent.
Method of medical rehabilitation of adolescent girls with acute complicated salpingoophorite / 2349328
Invention concerns medicine, particularly gynecology and medical rehabilitation of adolescent girls with acute complicated salpingoophorite. It involves 3 plasmapheresis sessions with small plasma exfusion volume in addition to antibacterial therapy over a day interval in post-operation period. Immediately after each plasmapheresis session 2.2 ml of Mucosa compositum, 2.2 ml of Coenzyme compositum and 2.2 ml of Tonsilla compositum is administered intravenously. Injections are repeated after medical plasmapheresis course, the total of 10 injections over one day interval. In addition, Nux vomika-Homaccord, Gynacoheel, Traumel C are administered internally by 10 drops three times per day for one month starting from the first day of therapy.
Method of treatment of bacterial purulent meningitis in children / 2348406
During acute period of purulent meningitis (BPM) additionally, Wobenzyme is prescribed in daily dose 1 tablet per 6 kg of body weight 3 times a day within 10 days simultaneously with antibacterial therapy. Treatment of meningococcal and pneumococcal meningitis is ensured with prescribed benzylpenicillin in daily dosage 300 thousand units/kg. Haemophilic meningitis is treated by prescribed Ceftriaxone in daily dose 100 mg/kg.
Method of treatment of subepithelial crape of cornea after photorefractive keratectomy / 2343885
After carrying out of photorefractive keratectomy (PRK), at revealing of complication in the form of a subepithelial crape, carry out lymphotropic therapy by performance of pterygopalatine blockades (PPB) course of 4-6 procedures, with an interval in day, with use of the medicinal admixture containing: 30-50 mg of lidocaine, 16-32 un of lydasums, 2-4 mg of histochrome, 0.5-1.0 mg of dalargin. The pterygopalatine blockades are carried out on the side of the damaged eye that provides fast entering and accumulation of medicinal substances in lymphatic region of an orbit.
 Treatment method of massive submacular hemorrhages / 2342105
Subtotal vitrectomy is carried out. After excision of a hyaloid, retinotomy of hemorrhage is carried out and vitreal cavity is filled with air. On the retina in the hemorrhage dimension recombinant prourokinases "gemaza" solution is injected in the amount of 0.3-0.5 ml 1500-2000 ME for 15-20 minutes and liquid blood fraction is evacuated from under the retina. The rest of the preparation is washed away. In case of incomplete excision of blood from under the retina, the vitreal cavity is filled with air again and recombinant prourokinases is repeatedly injected in the same volume of 500-1000 ME. Air is replaced by aeriform perfluorineorganic bond. After the operation the patient is placed in "on back" position for 2 hours, and then in "face downwards" position for 1-3 days. The method allows to carry out valid and accelerated fibrinous clot lysis which makes a basis of hemorrhage.
Method of medicinal therapy of disseminated malignant neoplasms / 2340355
During a course of chemotherapy administer sodium enoxaparin to the patient daily in a dosage of 40 mg a day subcutaneously and in addition, preparation of system enzymotherapy Vobenzyme in a dose of 3 tablets 3 times a day perorally.
Method of treatment of dermal stretch marks / 2338562
Spend mesotherapy of the stretch marks area with an admixture of preparations the tsel-T and kutis-kompozitum at 1:1. Carry out injections immediately in area of dermal defects on 0.1 ml of a solution through every 2-3 mm. Then perform phonophoresis of Lydasums in the stretch mark area within 10-15 minutes. Alternate the specified procedures in day with carrying out of applications of cosmetic clay on the stretch marks area within 30-40 minutes at temperature of 40-50°C.
Lumbodynia treatment method / 2356528
Invention refers to medicine, namely to neurology. The method implies acupuncture by inserting the needles and physical exercises including flexion, extension, left and right rotation, left and right lateroflexion. Herewith at first the patient while making physical exercises series informs on pain zones that the doctor palpates finds points of maximum tenderness, marks them and inserts the needles while the patient is in the standing position. Then the patient makes painful movements again 10-12 times. In movement gap, the doctor rotates the inserted needles counterclockwise. In case there is no new pain zones observed, the patient makes exercises again 3-4 times. If new pain zones are found, they are examined for points of maximum tenderness with inserting the additional needles therein, while patient continues with making exercises. If pain zones are detected in making various exercises, the patient makes pelvic rotations as a combination of all the movements in lumbar spine. After the exercises, the needles are removed.
|
FIELD: medicine. SUBSTANCE: invention refers to medicine, particularly to endocrinology. The method includes exposure of pair biologically active points (BAP) V20, R7, MC6, E36, RP6, RP4, E45 by introduction of preparation Coenzyme compositum in the specified BAPs. At first the preparation is injected intracutaneously by papule method of diametre 0.2 - 0.3 cm, then a needle is inserted deeply thus creating the preparation depot at total dose 0.2 ml per a point. Injections follow twice a week at therapeutic course 10 procedures. EFFECT: method normalises indices of lipid exchange and carbohydrate metabolism, improves life quality of the patients. 2 ex
The invention relates to medicine, in particular to endocrinology, namely the treatment of obesity, and can be used in medical institutions recovery profile. Currently, the increasing number of obese people is one of the most serious health problems. Statistical data of many studies indicate increased morbidity and mortality in people with overweight compared with persons with normal body weight. Obesity contributes to the development of insulin resistance and is a major risk factor for developing diabetes of the second type. Research in recent years has been established the relationship of overweight with the development of coronary heart disease, hypertension and atherosclerosis. Obesity is often accompanied by obstructive sleep apnea, arthritis, infertility and high risk of cancer of the colon, ovaries, mammary glands. The mortality of patients with severe forms of obesity 12 times higher than in persons with normal weight. There is a method of treating obesity through the use of pharmaceuticals, for example, sibutramine (meridia). Its mechanism of action is based on inhibition of the reuptake of neurotransmitters serotonin and noradrenaline. Effect reduced the I body weight when applying the sibutramine is based on two different mechanisms: a decrease in food intake as a result of rapid development of satiety and increased energy expenditure (thermogenesis). Sibutramine is prescribed in a dose of 10 mg 1 time per day regardless of food intake in combination with a diet low in energy value (McNeely W., Goa K.L. Sibutramine: a review of its contribution tot he management of o besity // Drugs, - 1998. - Vol.56, No. 6, P 1093-1124). The disadvantages of this method are the side effects of the drug expressed in occurrence of dry mouth, insomnia or drowsiness, constipation, loss of appetite, increased heart rate, on average 3-6 times per minute, the increase of diastolic blood pressure by 4 mm Hg the disadvantages also include the incompatibility of sibutramine with other medicines (eg, for treatment of depression) due to the likelihood of "serotonin syndrome". Also known is a method of treatment of patients with exogenous constitutional obesity by diet. The diet is chosen individually for each patient, taking into account body mass index, severity of risk factors for cardiovascular and other comorbidities. The basic principles are to reduce the share of energy coming from fat food to less than 30%; reducing saturated fat in the diet; reduce the total energy value of the daily diet of 300-600 kcal or more (Butrova S.A. the Treatment of obesity. - M., 2000). The disadvantages of this method are weak motivation of patients to treatment with diet, and, as the consequence, frequent breakdowns and return to the usual diet. A low-calorie diet often cause the development of fatigue, neurotic States, depressive reactions, disorders of water and electrolyte balance. In addition, neuroendocrine disorders, characteristic of obesity, significantly reduce the resistance to stress and hard diet acts as a stress factor, exacerbating neuroendocrine dysfunction. So, if weight loss is achieved only with the help of diet, soon, as a rule, not only returns the previous weight, but continues its growth. It is known that due to disorders of the neuroendocrine regulation of metabolic processes may further increase of overweight even at relatively low calorie intake. The closest in technical essence to the proposed method of treatment is a method of treatment of patients with exogenous constitutional obesity, is the impact on patients using acupuncture. Foot reflexology impact on biologically active points, you can influence carbohydrate, lipid and water-salt metabolism, normalize the activity of internal organs and glands; it gives the opportunity to correct disorders of autonomic regulation and to have a positive effect on psycho-emotional state of the patient (In whom gralic VG, Vohralik M.V. "Puncture reflexology Zhen-JIU - Gorky, 1988). The disadvantages of this method are different from the classical approach to diagnosis and treatment of patients, a small number of specialists who have mastered this technique, and, as a consequence, its limited use in medical practice. This is due to the fact that the most effective combination of points can only be found individually for each patient, with each specific day and hour. To an even greater extent this applies to the selection method, the point of impact strength, duration, tempo, rhythm, amplitude, speed, to avoid excessive reflex loading. Depending on individual sensitivity, the same exposure parameters may have different effects per patient - inhibitory (sedative) effects, and the other is a tonic and aphrodisiac. The technical result of the proposed method of treatment of patients with exogenous constitutional obesity is loss of appetite, significant decrease in body mass and prevent further set, the correction of comorbidities and, consequently, improve the quality of life of such patients. The specified technical result is achieved by subcutaneous injection of the contents of one ampoule (2.2 ml) integrated Goma is pricescope drug coenzyme compositum in paired biological active points, enhancing the metabolism and stimulating diuresis (V20, R7), normalizing bowel function and biliary tract (MS, E36), points that can help reduce feelings of hunger and thirst (RP4, e); reduce the level of atherogenic blood fractions (E36, MS), and in each point impose 0.1-0.2 ml of the drug with a frequency of 2 times per week, at the rate of 10 treatments. Part of the preparation of the German company "Biologiche Heilmittel heel GmbH coenzyme compositum includes both homeopathic and potentiated trace elements and intermediate catalysts, due to which the drug has a pronounced therapeutic effect in a blocked or inactive enzyme system and contributes to the normalization of oxidative processes in the cell. Input dose of 0.1-0.2 ml for the expressed clinical effect and no burning sensation at the injection that was observed with the introduction of a large dosage of the drug. For carrying out the proposed method for the treatment of patients with exogenous constitutional obesity, the patient was placed on the couch, has been the treatment of the skin at the injection 70% alcohol. For injection was used syringe 2 ml, and the needle 13 mm No. 30-32G. Methodology introduction coenzyme compositum consisted of two stages. In the first stage, the drug was injected intradermally method papules (diameter of 0.2-03 cm). After that, the needle was injected deeply and left the depot in 0.1-0.2 ml per point. Conducted consistent drug coenzyme compositum in the following pair of biologically active points: E36 (tibia), MS (forearm), RP4 (foot), e (foot), V20 (paravertebral), R7 (foot). After the injection the skin was again treated with 70% ethanol, and then the skin surface was dried with a cloth. Treatment consisted of 10 sessions with a frequency of 2 times per week. Example 1. Patient H., 47 years with a diagnosis of exogenous constitutional obesity of 1 degree. Arterial hypertension of the 1st degree. Chronic cholecystitis. For the method of treatment of patients with exogenous constitutional obesity, the patient was placed on the couch, she has been the treatment of skin at the injection site 70% alcohol. For injection was used syringe 2 ml, and the needle 13 mm No. 30-32G. In the first stage, the drug coenzyme compositum was injected intradermally method papules (diameter 0.3 cm). After that, the needle was injected deeply and left the depot of the drug at a rate of 0.1 ml per point. Conducted consistent drug coenzyme compositum in paired biologically active points: E36 (tibia), MS (forearm), RP4 (foot), e (foot), V20 (paravertebral), R7 (foot). After the injection the skin was again treated with 70% JV the mouth, and then dried with a cloth. Treatment consisted of 10 sessions with a frequency of 2 times per week. As a result of treatment, the patient noted a decrease excessive appetite (from 8 to 3 Units according to the visual analogue scale), the lack of a sense of heaviness in the right hypochondrium. Decreased body mass index with to 32.8 30.7, and the dynamics of body weight amounted to 5.9 pounds by reducing body fat in percentage and proportions. According to the lipid was a decrease of atherogenic fractions of blood (triglycerides, cholesterol, β-density lipoprotein) and increase antiatherogenic α-cholesterol. Example 2. Patient N., 39 years old with a diagnosis of exogenous constitutional obesity of 2 degrees. Impaired glucose tolerance. For the method of treatment of patients with exogenous constitutional obesity, the patient was placed on the couch, he had been the treatment of skin at the injection site 70% alcohol. For injection was used syringe 2 ml, and the needle 13 mm No. 30-32G. In the first stage, the drug coenzyme compositum was injected intradermally method papules (diameter 0.2 cm). After that, the needle was injected deeply and left the depot of the drug at the rate of 0.2 ml per point. Conducted sequential introduction coenzyme compositum in paired biologically AK is positive point: E36 (tibia), MS (forearm), RP4 (foot), e (foot), V20 (paravertebral), R7 (foot). After the injection the skin was again treated with 70% ethanol, and then dried with a cloth. Treatment consisted of 10 sessions with a frequency of 2 times per week. As a result of treatment the patient reported a decrease of excess appetite from 7 to 3 Units according to the visual analogue scale; there was a decrease of body mass index with to 36.2 34.2, and the dynamics of body weight was 6.1 pounds by reducing body fat in percentage and proportions. According to the lipid was a decrease of atherogenic fractions of blood (cholesterol, β-density lipoprotein) and increase antiatherogenic α-cholesterol. The laboratory investigations revealed a reduction of the initially elevated levels of immunoreactive insulin, normalization of indices of glycemic curve, indicating that the reduction of insulin resistance is the main link pathogenesis of exogenous constitutional obesity. The proposed method of treatment was used in 60 patients. As a result of application of the method of treatment of patients with exogenous constitutional obese patients noted a significant decrease in appetite (from 8 to 4 according to the visual analogue scale), a significant reduction of body mass on 5,17 is 1.13 kg (p< 0,001), mainly due to loss of adipose tissue 3.16±1,04 kg (p<0,001) according to bioelectromagnetism; reduction of atherogenic fractions of the blood, reducing the initially high level of immunoreactive insulin and blood glucose, reducing the severity of comorbidity, improved psycho-emotional status (according to tests RESINS, SAN, luser). The advantages of this method is the impact of complex homeopathic preparation on biologically active points; by creating a depot of the drug effect is of a prolonged nature. This method allows to achieve a clinically significant anorectic effect on the background of the intensification of metabolism. Providing regulatory, detoxification, stimulating the body's defenses to the action, this method does not cause allergic reactions, side effects and allows simultaneous treatment of opportunistic diseases. The technique is simple to use, the duration of treatment allows to observe the patient during the month, which increases the complexity of the treatment of exogenous constitutional obesity. As a result of application of the method of treatment in patients with significantly decreased appetite, decreased body weight, normalized carbohydrate and lipid metabolism. Monitoring patients for 5-6 IU azev after treatment showed no tendency to increase appetite or increase body weight. Method of treatment of exogenous constitutional obesity by acting on paired biologically active points (BAP) V20, R7, MS, E36, RP6, RP4, e, characterized in that the influence exercised by the introduction of these BAT drug coenzyme compositum, with the first drug injected intradermally method papules, with a diameter of 0.2-0.3 cm, and then the needle is injected deeper, creating a depot of the drug at a rate of 0.1-0.2 ml per pixel, the introduction is carried out 2 times a week, on a course of 10 treatments.
|