Method of treatment of bacterial purulent meningitis in children
SUBSTANCE: during acute period of purulent meningitis (BPM) additionally, Wobenzyme is prescribed in daily dose 1 tablet per 6 kg of body weight 3 times a day within 10 days simultaneously with antibacterial therapy. Treatment of meningococcal and pneumococcal meningitis is ensured with prescribed benzylpenicillin in daily dosage 300 thousand units/kg. Haemophilic meningitis is treated by prescribed Ceftriaxone in daily dose 100 mg/kg.
EFFECT: higher efficiency of BPM specific therapy due to Wobenzyme ability to improve antibiotic penetration through blood-brain barrier and transport to inflammatory tissue and autointoxication reduction.
3 cl, 2 tbl, 4 ex
This invention relates to the field of medicine, more specifically to the CNS, and is intended for the treatment of children with purulent bacterial meningitis (HMD), and can be used in clinical practice.
HMD - acute bacterial polietiologic inflammation of the membranes of the brain, characterized by intoxication syndrome, meningeal syndrome, syndrome, encephalitis, inflammatory changes in the cerebrospinal fluid (CSF), and in complicated cases - by edema and brain swelling, and multiorgan failure. The urgency of the problem HMD in children due to mortality (25%), high incidence of complications (30%), the presence of residual neurological effects from 15-30%. The widespread prevalence of the tendency to increase of the frequency of prolonged and chronic and high frequency of lethal and incapacitating outcomes determine the urgency of the problem HMD in children.
Known methods of treatment HMD, including causal (antibiotics) and pathogenic (holding detoxification, dehydration therapy, the use of antihypoxants and nootropics) therapy. Etiotropic therapy aimed at eliminating direct etiological causes of the disease, the success of which depends on: the type of pathogen, the degree of permeability is hematoencephalic barrier (BBB) for drug dose of antibiotic, route of administration, etc. However, the use of different antibiotics in the maximum doses in the HMD in children leads to the development of dysbacteriosis, signs of toxic effects of the drug in 60% of patients, which lengthens the presence of the patient in the hospital (Lobzin J.V. Selected questions of the treatment of infectious patients / physicians Manual / St. Petersburg: Folio, 2005).
There are also known methods of treatment HMD using antibacterial products, aimed at the elimination of the pathogen, with different dosages (Meronem - 120 mg / kg body weight / day, rifampin 20 mg per kg of body weight a day, a course of 10 to 20 days each). The increase of antibiotic resistance in the last two decades, the emergence of protracted forms of HMD in children cause a 25% change etiotropic drugs during treatment HMD, and a 40% increase in the duration of antibiotic therapy, which leads to a longer stay of the patient in hospital and increased frequency of complications (Yakovlev V.P. Rational antimicrobial therapy. M: Littera, 2003).
Closest to the proposed method is the use of antibiotic therapy in combination with vascular and nootropic drugs, on the background of the prolonged infusion therapy (5-7 days), which helps reduce intoxicat and and duration of inflammation in the CSF, to improve the rheological properties of blood. From the funds etiotropic therapy is most often used are the following drugs: chloramphenicol dose of 70-100 mg per kg of body weight, benzylpenicillin in a daily dose of from 250 thousand to 500 thousand units unit rate from 10 to 20 days, Ceftriaxone at a daily dose of 50 to 200 mg rate from 10 to 20 days. However, this therapy does not need to change antibiotic in 25% of cases, leading to protracted course of the disease and the presence of dysbacteriosis in 90% of cases. The use of vascular and nootropic drugs prescribed in addition to antibacterial, admittedly non-specific, mediated by improving microcirculation, aiming at enhancing the action of the antibiotic, which does not contribute to reduction of treatment time and reduce side effects.
The technical result achieved by the invention is the reduction of treatment time, reducing the severity of disease, number of complications. This is achieved by improving the transport of antibiotic in the inflammation, reduce toxicity and side effects of antibiotics.
The invention consists in the achievement of the technical result in the treatment HMD in children through the use of penicillin and Ceftriaxone, and according to the SNO invention in the acute period, additionally, simultaneously with antibacterial therapy is prescribed Wobenzym orally in a daily dose of 1 tablet of the drug for 6 kg of body weight, 3 times a day for 10 days.
2. The method according to claim 1, characterized in that when meningococcal and pneumococcal meningitis appoint benzylpenicillin in a daily dose of 300 thousand units/kg per day.
3. The method according to claim 1, characterized in that when Haemophilus influenzae meningitis prescribe Ceftriaxone in a daily dose of 100 mg/kg per day.
Wobenzym - drug systemic enzyme therapy, increases the permeability of membranes. It is used as a booster therapy (therapy amplification) in children with infectious diseases of the upper respiratory tract, urogenital system. It is quite safe, compatible with traditional means of treatment of bacterial diseases. In the treatment of HMD in children have not been applied.
The authors first discovered the feasibility and efficacy of the simultaneous use of Wobenzym and antibiotics penicillin and Ceftriaxone with HMD. The authors found a dose and duration combined use of antibacterial drugs with systemic enzymes with HMD in children. Found that simultaneous administration of the two drugs promotes better penetration of antibacterial agents through the blood-brain barrier, which is, according to the authors, the Rheine needed given intrathecal localization of the inflammatory process. The authors showed not only the ability of Wobenzym to potentiate the action of antibacterial drugs in HMD, but also to contribute to the reduction of endogenous intoxication. This property was discovered in the study of substances of low and medium molecular weight (VNSM) plasma and red blood cells when HMD in children (table 1).
|Groups of patients with different severity of inflammation of the brain||The number of patients||VNSM plasma ($)||CRP (mg/l)|
|Acute||3-5 day diseases||Acute||Reconvalescent|
|Benzylpenicillin + Wobenzym||25||18,43±4,12x||11,65±3,41°||47,8±3,6x||7,65±4,9°|
|Ceftriaxone + Wobenzym||24||17,64±5,63x||10,34±2,65x||54,6±5,6x||4,3±3,6x|
|x - the difference is significant compared to the control|
|° - the difference is significant compared to the comparison group|
|* - the difference is significant compared with the group of antibiotic + Wobenzym|
The authors have developed dose, duration, and frequency assignment of Wobenzym with HMD in children. The authors proved that Wobenzym reduces the severity of side effects etiotropic drugs reduces their toxicity that can significantly improve outcomes, reduce the duration of a patient's hospitalization (table 2).
|The group of patients||The number of patients||The degree of pleocytosis (×106/l)||The duration of symptoms of|
|Headache||Meningeal syndrome||Fever||Focal symptoms||Dysbacteriosis||Bed-days|
|benzilpenicillin + Wobenzym||25||10000±320||1,4±0,6°||2,3±0,6°||2,9±1,8°||0°||0,4±0,2°||10,3±1,9°|
|Ceftriaxone + Wobenzym||24||11200±240||2,1±0,2°||3,3±1,62°||3,2±0,62°||1,7±0,7°||2,2±0,6°||13,4±3,4°|
|° - the difference is significant compared with group antibiotic|
|*- the difference is significant compared with the group of antibiotic + Wobenzym|
The authors first got the positive result of the appointment of Wobenzym in protracted (long readjustment CSF) flow types HMD, when the background neodeck atoi change of antibiotic therapy was negative clinical and laboratory dynamics. The use of Wobenzym helped to achieve a positive effect, without resorting to the intrathecal injection of antibiotic. The positive effect and no complications were allowed to use Wobenzym as drug pathogenetic therapy in combination with etiotropic drugs (example 4).
The authors proved that the combination therapy with exhaust dosage provides the effect, which leads to better outcomes in HMD. In the available literature such treatments HMD is not described. The choice and dosage of antimicrobial drugs based on our monitoring of antibiotic susceptibility with regard to the least side effects. It should be noted that 95% of bacterial purulent meningitis in children are caused by meningococcus, pneumococcus and Haemophilus influenzae, the most effective drug in the treatment of meningococcal and pneumococcal meningitis is penicillin at a dose of 300 thousand units per kg of body weight per day, according to our records this dose is effective, does not produce toxic effects, sufficient for illumination of the pathogen. Ceftriaxone - antibiotic from the group of cephalosporins of the third generation, highly effective against Haemophilus influenzae Bacillus, and in a dose of 100 mg per kg of body weight per day, as shown by the ASHI research is effective with a proven dosage.
The method is as follows: when entering a patient with HMD, after conducting infusion therapy, meningococcal and pneumococcal HMD in addition to the purpose of benzylpenicillin in a daily dose of 300 thousand units/kg / day in the acute period of the disease is for oral administration Wobenzym in a daily dose of 1 tablet of the drug for 6 kg of body weight, 3 times a day for 10 days, with Haemophilus HMD in addition to the purpose of Ceftriaxone in a daily dose of 100 mg/kg / day appointed Wobenzym in a daily dose of 1 tablet of the drug for 6 kg of body weight, 3 times a day for 10 days. The diagnosis was confirmed by examination of the cerebrospinal fluid with the release of the pathogen or antigen.
A method of treating HMD passed clinical trials in the treatment of 25 children aged from 2 years to 17 years in the clinic of the CNS NEEDY. Of these 20 children (80 per cent) was established meningococcal etiology of the disease, 2 patients (8%) - selected pneumoniae, have 3 children (12%) - Haemophilus influenzae. Depending on the duration of the slew of neurological symptoms all patients were divided into groups. All patients in this group received therapy according to the claimed method.
The comparison group consisted of 24 children who received standard etiotropic terap the Y. The comparison group was matched by sex, age and nature of the disease. All patients underwent clinical and laboratory monitoring for monitoring and follow-up within 1 year. In the result, it was found that the use proposed by the authors of this method of treatment has allowed to improve outcomes and reduce length of stay in hospital (15%) patients of the first group in the clinic, as well as to reduce the frequency of residual deficit (20%), dysbiotic disorders (60% of cases). As in the main group and the comparison group were observed moderate for HMD, but in the main group of children duration of antibiotic therapy was 7.4±2,8, and in the comparison group significantly longer and amounted to 10.1±6.2 percent. If the main group of the need to use broad-spectrum antibiotics was observed only in one patient in the comparison group the need for change of antibiotic occurred in 22% of cases. The effectiveness of this treatment method can be confirmed by the following examples.
Example 1. Patient D., aged 13. Case history No. 1478, a diagnosis of generalized form of meningococcal infection, meningococcemia, purulent meningitis. Ill acutely, there was a sharp rise of temperature up to 39.5 degrees, headache, appeared hemorrhagic rash. Hospitalized in NEEDY in PE is the first day of the disease. When entering a serious condition. In the neurological examination - moderate severity meningeal symptoms (stiff neck (++), symptom, Cernica (+),) focal neurological symptoms in the form of the asymmetry of the eye slits. Analysis of cerebrospinal fluid (CSF) lymphocytosis 4398×106/l, total protein and 0.46 g/l Data quantitative research content VNSM (substances of low and medium molecular weight) plasma - 26,23 conventional units (cu). C-reactive protein (CRP) - 54 mg/l, which corresponds to a pronounced degree of endogenous intoxication and inflammation. The first day the child was in the intensive care unit. Immediately after receiving the child received benzylpenicillin dose of 300 thousand per kg of body weight 6 times a day and Wobenzym at the rate of 1 tablet per 6 kg of body weight three times a day. On the background of therapy condition has improved, meningeal syndrome were stopped on the third day. Repeated lumbar puncture performed on the 6th day: protein - 0.3 g/l, lymphocytosis - 18×106/l VNSM - $ 8, CRP - 3 mg/l, which corresponds to almost the normal level of endogenous intoxication, no signs of inflammation. Thus, in this case, the background of therapy was observed favorable course of the disease, the child was discharged on the 8th day without complications, having increased the I-dose antibiotic or drug use broad-spectrum was not.
Example 2. Patient L., 4 years 7 months. Case history No. 4832, diagnosed with generalized form of Haemophilus influenzae infection, purulent meningitis. Ill acutely, fever up to 39 degrees, 9 times vomiting, anxiety, tremors, on the left hip appeared hemorrhagic rash. Hospitalized in NEEDY in the first days of the disease. When entering a serious condition, consciousness at the level of the spoor. Focal neurological symptoms absent, marked meningeal symptoms: stiff neck (+++), a symptom of Cernica (+++). In the analysis of CSF: lymphocytosis - 5547×106/l, protein - 2,13 g/l Content VNSM plasma - $ 25,46, CRH - 48 mg/l, which corresponds to a pronounced degree of endogenous intoxication and inflammation. The patient received Ceftriaxone at a dose of 100 thousand per kg 4 times a day, in addition to etiotropic therapy was added Wobenzym in the dose of 1 tablet per 6 kg mass. The time spent in the intensive care unit for 24 hours. Studies in the dynamics (10 day) showed positive shifts in the composition of the liquor: lymphocytosis - 24×106/l, protein - 0,44 g/l, VNSM - 9,45$, CRP - 5 mg/L. Meningeal syndrome were stopped on the third day. The patient was discharged without residual effects. Thus, on the background of therapy has been a rapid regression of neurological symptoms and normalization of laboratory data. Balnaves without complications on the 9th day of illness.
Example 3. Patient C., 1 year. Case history No. 1242, diagnosed with generalized form of meningococcal infection, purulent meningitis. Enrolled in the intensive care unit of NEEDY in the first days of the disease. Ill acutely, there was an increase of body temperature up to 38 degrees, three times vomiting. When entering a serious condition: consciousness is not impaired, expressed meningeal symptoms, focal symptoms are not identified. The study CSF: lymphocytosis - 3386×106/l, total protein - 1,94 g/l, VNSM - $ 16,23, SLO - 36 mg/l, which corresponds to a pronounced degree of endogenous intoxication and inflammation. Etiotropic treatment included the appointment of benzylpenicillin dose of 300 thousand per kg per day. However, on the background of therapy remained meningeal symptoms, the child continued fever, on the 7th day from diseases produced by lumbar puncture: lymphocytosis - 2674×106/l, total protein - 1,03 g/l, VNSM plasma -18,32 c.u., SLO - 28 mg/l was changed antibacterial therapy rifampicin at a dose of 20 mg/kg. the Child was discharged at 38 days after the onset of the disease with severe asthenia, fronto-cerebellar ataxia.
Example 4. Patient C., 1 year 1 month. Case history No. 1368, a diagnosis of generalized form of meningococcal infection, purulent meningitis. He entered NEEDY on the second day of the disease. Ill acutely, promoted the eating of body temperature up to 40 degrees, was once vomiting, drowsiness. When entering a serious condition: consciousness is not impaired, expressed meningeal symptoms, focal symptoms were not. The study CSF: lymphocytosis - 4531×106/l, total protein - 0.84 g/l, VNSM - $ 18,23, SLO - 48 mg/l, which corresponds to a pronounced degree of endogenous intoxication and inflammation. The drug of choice was benzylpenicillin dose of 300 thousand per kg per day. The patient was conducted infusion therapy. On the background of therapy was noted positive dynamics of clinical symptoms, but the patient with 13 days of hospital stay was trouble appeared frequent liquid stool, on the 13th day from diseases produced by lumbar puncture: lymphocytosis - 3629×106/l, total protein 0.9 g/l, VNSM plasma - $ 18,32, SLO - 64 mg/l was changed antibacterial therapy first darifenacin at a dose of 20 mg/kg, positive dynamics was not received, then numeronym at a dose of 120 mg per kg of body weight per day. The state has remained severe, the child continued fever. In therapy with 25 days of hospital stay in addition to the antibiotic was appointed Wobenzym, at a dose of 1 tablet per 6 kg of body weight per day, the child has no fever for 3 days from receiving the drug. Duration of use of Wobenzym was 10 days. During the control study CSF was noted but militaria cellular and protein composition. The child was discharged without complications.
Thanks to the use proposed by the authors of complex therapy HMD children were able to improve the outcomes of the disease, significantly increasing the percentage of children fully recovered without neurological abnormalities, to reduce the duration of hospital stay due to a more rapid reorganization of the liquor. This method can find a wide primeneniia in clinical practice in the treatment of children with severe generalized bacterial infection. Using this technique will strengthen the action of antibacterial drugs without frequent change of antibiotic without increasing the dosage.
1. A method of treatment of purulent bacterial meningitis in children, including the use of penicillin and Ceftriaxone, characterized in that in the acute period advanced, simultaneously with antibacterial therapy is prescribed Wobenzym in a daily dose of 1 tablet of the drug for 6 kg of body weight 3 times a day for 10 days.
2. The method according to claim 1, characterized in that when meningococcal and pneumococcal meningitis appoint benzylpenicillin in a daily dose of 300 production/kg per day.
3. The method according to claim 1, characterized in that when Haemophilus influenzae meningitis prescribe Ceftriaxone in a daily dose of 100 mg/kg per day.
SUBSTANCE: invention concerns peptide compounds representing an amino acid sequence X1KEFX2RIVX3RIKX4FLRX5LVX6, where X1 is N-end segment which is IG; X2 is K or E; X3 is Q or E; X4 is D or R; X5 is N or E; X6 is C-end segment, which is a sequence selected out of PRTE or RPLR; where N-end segment is acetylated and/or C-end segment is amidated; with affinity to toxins, particularly to bacterial toxins, such as lipopolysaccharide or lipoteichoic acid. These compounds can inhibit or neutralise toxins. Invention also concerns pharmaceutical compositions and application of the claimed compounds in prevention or treatment of diseases or states caused by fungi or bacterial infection.
EFFECT: obtaining compounds for prevention or treatment of diseases or states caused by fungi or bacterial infection.
12 cl, 4 tbl, 4 ex
FIELD: medicine; biotechnologies.
SUBSTANCE: vaccine drug includes deactivated Escherichia coli bacteria of strain No 389 (078) and auxiliary substances. Additionally the drug includes aminoethylethyleneimine and liposome-forming mix as auxiliary substance at the following component rate in fluid form, wt %: aminoethylethyleneimine - 0.5-3; liposome-forming mix - 7.3-15; suspension of deactivated Escherichia coli bacteria of serotype 078 - 82.0-91.5.
EFFECT: harmless for fowl, enhanced antigenic and immunogenic activity.
3 cl, 4 tbl, 6 ex
FIELD: medicine; veterinary.
SUBSTANCE: medicine includes metal iodine and potassium iodide, prolongator and water. 1,2-propylene glycol is used as prolongator, and additionally vitamin A (retinol acetate), vitamin E (alpha-tocopherol acetate), vitamin B1 (thiamine hydrochloride), vitamin B2 (riboflavin), vitamin B6 (pyridoxine hydrochloride), vitamin B12 (cyanocobalamin), iron carbonate, magnium phosphate, manganese sulfate, copper sulfate, zinc sulfate, cobalt chloride, sodium chloride, amber acid, glucose, rectified ethyl alcohol (96%) are applied. Medicine components are taken at the following rate, g/100 ml of distilled water: metal iodine, chemically pure 0.112-0.187; potassium iodide, R 0.337-0.562; vitamin E (alpha-tocopherol acetate) 0.060-0.100; vitamin A (retinol acetate) 3.750-6.250 thousand mass units; vitamin B1 (thiamine hydrochloride) 0.052-0.087; vitamin B2 (riboflavin) 0.037-0.062; vitamin B6 (pyridoxine hydrochloride) 0.034-0.056; vitamin B12 (cyanocobalamin) 0.026-0.044; iron carbonate, R 0.337-0.562; magnium phosphate, R 0.337-0.562; manganese sulfate, R 0.172-0.287; copper sulfate, R 0.090-0.150; zinc sulfate, R 0.315-0.525; cobalt chloride, R 0.071-0.119; sodium chloride, R 0.589-0.981; amber acid, primary standard 0.225-0.375; glucose, AR 0.172-0.287; rectified ethyl alcohol (96%) 0.300-0.500 ml; 1,2- propylene glycol 0.900-1.500 ml. Method involves medicine administration with fodder in dosage of 1.00-1.50 mg per 1 kg of fish weight once per day for 5-7 days.
EFFECT: correction of needs for bioactive substances, prevention of avitaminosis, achievement of high antioxidant organism protection level, prevention of accumulation of non-saturated fatty acid peroxides harmful to fish.
2 cl, 3 tbl, 3 ex
FIELD: medicine; pharmacology.
SUBSTANCE: invention is used for treatment of bacteriemic infections, it is prepared as composition in the form of dry powder, adapted for delution by water with reception of the suspension important pH in a range from approximately 5.0 to approximately 5.5 at initial delution and which in addition contains the stabilizer pH which represents sodium-carboxymethyl cellulose. Besides, the invention concerns application sodium-carboxymethyl cellulose for reduction of degree of degradation clavunalate and for stabilisation pH the received suspension.
EFFECT: stability improvement in preparation.
7 cl, 1 dwg, 1 tbl
SUBSTANCE: method is implemented as follows: bacterial-enzymatic probiotic "Balance-narine-f" is introduced locally and orally in combination with inhalation of negative air ions.
EFFECT: allows for decrease of complications and higher efficiency of treatment.
1 tbl, 3 ex
SUBSTANCE: sterile aqueous inhalation solution containing active substance Tobramycine. Preparation of invention is offered with high content of active substance (approximately 80 to 120 mg/ml Tobramycine). Preparation also contains acid adjuvant and has low content of sodium chloride (maximum approximately 2 mg/ml). Preparation can be injected or introduced as aerosol with e.g. common sprays.
EFFECT: suitable for application in combination with recent sprays with vibrating membrane and gives the chance for application of an individual therapeutic dose.
24 cl, 1 tbl, 7 ex
SUBSTANCE: antibacterial and rehydration therapies are combined with prescribed sorbents, symptomatic therapy. From first day of disease prescribed is infusion herb collection consisting of silverweed rhizome, salvia leaves, milfoil herb, St. John's wort herb, inula rhizomes with roots, tickseed herbs, mint leaves, fennel fruits and buckthorn bark at ratio of components 2:2:2:2:2:2:2:2:1. Infusion is taken up dosed 1\3 glass 3 times a day, 30 min before meal within 10 days. Then within three weeks after basic therapy appoint infusion from silverweed rhizome, salvia leaves, milfoil herb.
EFFECT: provides accelerated normalisation of clinical-laboratory indicators, and prevention of infectious complications without by-effects.
2 cl, 1 tbl, 1 ex
FIELD: medicine; biotechnologies.
SUBSTANCE: strain Lactobacillus casei FERM BP-100059 (FERM P-19443), possessing probiotic properties; grow up in the presence of any from one to four amino acids as a source of the nitrogen necessary for growth. At planting in suitable cultural to medium, the final value pH makes 4.0 or lower, and the highest acidity makes 1.5% or above. The strain resistable is to 5% salts of cholic acids. The strain produces an antibiotic. On the basis of the strain as the active beginning, the lactobacillus preparation of probiotic action for humans, animals and plants and the preventive or therapeutic agent against human, animal and plant infections.
EFFECT: ability to colonise and breed in the centres chronic the infections, steady against treatment, strong clearing action and destruction causing a bacterium infection.
12 cl, 5 dwg, 56 tbl, 34 ex
FIELD: medicine; pharmacology.
SUBSTANCE: peroral pharmaceutical dosed out form for treatment of the conditions bound to secretion of acid in a stomach, includes an acid-sensible inhibitor of the proton pump and antagonist of H2-molecular switchers, with the delayed and-or prolonged liberation of the proton pump acid-sensible inhibitor, and fast liberation of antagonist of H2-molecular switchers.
EFFECT: maximum suppression of acid in a stomach after the first dose and throughout all course of treatment.
69 cl, 4 dwg, 7 ex
FIELD: medicine; veterinary science.
SUBSTANCE: vaccine includes inactivated adhesive antigens E.coli K88, E.coli K99, E.coli F-41, E.coli 987P and an adjuvant - aluminum hydrate. As the inactivated adhesive antigens E.coli use inactivated filamentous adhesive antigens E.coli K88 ab, E.coli K88 ad, E.coli K88 ad, E.coli K99, E.coli F-41, E.coli Att-25, E.coli 987P with activity level in reaction of the passive hemagglutination peer as 1:2048-4096; 1:1024-2048; 1:256-512; 1:1024-2056; 1:1024-2056; 1:32-64; 1:256-512, accordingly, at a following parity of components, wt. %: inactivated filamentous adhesive antigens E.coli K88 ab, E.coli K88 ad, E.coli K88 ad, E.coli K99, E.coli F-41, E.coli Att-25, E.coli 987P, taken in mass parities 1:(0.8-1.2:(0.8-1.2:(0.8-1.2:(0.8-1.2:(0.8-1.2:(0.8-1.2, accordingly - 55-65, 5.8-6.2%-s' aluminium hydrate the rest.
EFFECT: rising of safety of livestock of agricultural animals.
2 cl, 1 tbl, 8 ex
FIELD: medicine; ophthalmology.
SUBSTANCE: after carrying out of photorefractive keratectomy (PRK), at revealing of complication in the form of a subepithelial crape, carry out lymphotropic therapy by performance of pterygopalatine blockades (PPB) course of 4-6 procedures, with an interval in day, with use of the medicinal admixture containing: 30-50 mg of lidocaine, 16-32 un of lydasums, 2-4 mg of histochrome, 0.5-1.0 mg of dalargin. The pterygopalatine blockades are carried out on the side of the damaged eye that provides fast entering and accumulation of medicinal substances in lymphatic region of an orbit.
EFFECT: increase of treatment efficiency.
FIELD: medicine; ophthalmology.
SUBSTANCE: subtotal vitrectomy is carried out. After excision of a hyaloid, retinotomy of hemorrhage is carried out and vitreal cavity is filled with air. On the retina in the hemorrhage dimension recombinant prourokinases "gemaza" solution is injected in the amount of 0.3-0.5 ml 1500-2000 ME for 15-20 minutes and liquid blood fraction is evacuated from under the retina. The rest of the preparation is washed away. In case of incomplete excision of blood from under the retina, the vitreal cavity is filled with air again and recombinant prourokinases is repeatedly injected in the same volume of 500-1000 ME. Air is replaced by aeriform perfluorineorganic bond. After the operation the patient is placed in "on back" position for 2 hours, and then in "face downwards" position for 1-3 days. The method allows to carry out valid and accelerated fibrinous clot lysis which makes a basis of hemorrhage.
EFFECT: termination of mechanical fibrin influence and liquidation of toxic influence of decomposition product of formulated blood elements on retina neuroepithelium and pigmental epithelium with minimisation of retina mechanical trauma during surgical intervention.
2 cl, 2 dwg, 1 ex
FIELD: medicine; oncology.
SUBSTANCE: during a course of chemotherapy administer sodium enoxaparin to the patient daily in a dosage of 40 mg a day subcutaneously and in addition, preparation of system enzymotherapy Vobenzyme in a dose of 3 tablets 3 times a day perorally.
EFFECT: potentiation of anticoagulate effect of low-molecular heparins, preventive maintenance of thrombotic complications for the account of lysis of fresh micro and macrothrombuses, prevention of formation of new thrombuses and reduction of microinnidiation process.
FIELD: medicine; dermatology.
SUBSTANCE: spend mesotherapy of the stretch marks area with an admixture of preparations the tsel-T and kutis-kompozitum at 1:1. Carry out injections immediately in area of dermal defects on 0.1 ml of a solution through every 2-3 mm. Then perform phonophoresis of Lydasums in the stretch mark area within 10-15 minutes. Alternate the specified procedures in day with carrying out of applications of cosmetic clay on the stretch marks area within 30-40 minutes at temperature of 40-50°C.
EFFECT: method excludes possibility of occurrence of allergic reactions and is simple in execution.
2 ex, 4 cl
FIELD: medicine, ophthalmology.
SUBSTANCE: in cases of large-swinging nystagmus, horizontal or rotatory, it is suppressed by implementing preoperational retrobulbar anesthesia with drug composition, containing: lydocaine - 20 to 40 mg, epinephrine - 0.4 to 0.5 mg, and lydase - 4 to 6 units. After the eyes moves are stopped, on average in 1 to 2 minutes, adjusting of the laser is made by macular reflex glow, and ablation is conducted. In cases of small- or middle-swinging horizontal nystagmus, after cornea flap cutting during conduction of laser keratomyleusis in situ or photorefraction keratectomy, vacuum ring is installed, and then in small-swinging nystagmus case adjusting of tracker is made, and in middle-swinging nystagmus case adjusting of laser by macular reflex glow is made. Whereupon, ablation is implemented.
EFFECT: method provides suppressing of any nystagmus kind and promotes lowering of nystagmus degree.
2 cl, 4 ex
FIELD: medicine, ophthalmology.
SUBSTANCE: under ophthalmoscope a single dose 500 IU of haemase is introduced into the eye epiretinal space, near thrombotic obturation zone of the vein. 14-16 days later, the retina coagulation by argon laser is carried out. Firstly, barrage of macular zone is implemented in horseshoe form, the fugure being opened towards disk of optic nerve. Coagulates are applied at the distance not less than 2500 mcm from the central pit in single flashes mode, rated 300 to 400 mW, exposition time 0.1-0.2 sec, and light beam diameter 50 mcm. Number of applications is 20 to 30. Then the laser is switched to automatic mode and coagulation of the rest retina parts is implemented, excluding the papillo-macular bundle. The same radiation parameters are used, except the light beam diameter is 100 mcm. Up to 500 application are made altogether, distanced to 2000 mcm one from another. In case of thrombosis of retina central vein branch, focal laser coagulation is carried out in the damaged branch quadrant only, by making up to 150 applications.
EFFECT: high and constant therapeutic effect under sparing laser therapy technique; complications diminishing during and after the treatment.
2 ex, 4 dwg, 6 tbl
SUBSTANCE: germicide includes bacteriemic nuclease in combinations with the electro activated water-salt solution containing 0.1% of potassium iodite and 0.3% sodium chloride, and the stabiliser glycerin or sucrose or polyvinyl pyrrolidone, or glycerin or an albumin. Creation of the preparation possessing virucidal, fungicidal, bactericidal and chlamidomicide action without expressed type and species specificity.
EFFECT: expansion of a spectrum of action of bacteriemic endonuclease.
1 tbl, 1 ex
SUBSTANCE: invention concerns medicine, namely to haematology, and is referred to the method of stimulation of myelopoiesis. For this purpose administer Hyaluronidasum in effective dose specially developed for it.
EFFECT: provision of wide spectrum of haemostimulating action on hemopoietic tissue, rendering thus the minimum medicinal load on an organism.
2 tbl, 2 ex
SUBSTANCE: invention concerns dentistry, particularly compositions for oral cavity hygiene improvement. The group of inventions includes composition for oral cavity care of increased stability and dental deposit fighting effect, as well as method for improving composition stability, and method for obtaining water composition for oral cavity care. The claimed composition includes carrier acceptable for oral cavity and containing a combination of ferment, cetylpyridinium chloride and reducing agent.
EFFECT: obtaining a composition with improved hygienic properties and dental deposit fighting effect.
37 cl, 2 ex, 11 tbl
FIELD: medicine, urology.
SUBSTANCE: susceptibility of pathogenic organism to antiprotozoan drugs is determined. At the preliminary stage sporobacterin, sulodexide, methadoxil, and vobenzyme are injected; the prostate is affected by ultrasound exposure. After that at the etiotropic treatment stage, the blood is taken and separated in plasma, erythrocyte suspension, and leukocyte suspension fractions by sequential centrifuging at 800 rpm and 1800 rpm speed and temperature +4°C. The plasma is eliminated and replaced by crystalloid solution. The erythrocyte suspension is injected intravenously to the patient. The leukocyte suspension, with 0.5 ml ATP added, is affected by semiconductor laser radiation exposure at λ=0.70 mcm, then 0.75 g of metronidazol in solution is added and, after incubation at +37°C, injected to the patient. Simultaneously nifuratel is administered perorally in 200 mg dose twice a day. The procedure is repeated during 8 days. At the rehabilitation therapy stage during 10 days trilact is administered by 2 doses twice a day, as well as polyvitamin mix "Alpha-Vit". The method provides directed metronidazol transport into infection focuses, activates autoblood cells metabolism and phagocytic, adhesive, and migration leukocyte activities, stimulates resorption of fibrotic degenerated chronic inflammation niduses in urino-genital tract, decreases manifestation of side effects.
EFFECT: increase in treatment effectiveness.
SUBSTANCE: invention relates to medicine, surgery, and can be used for X-ray diagnostics of esophagus perforations. For this purpose X-ray contrast composition is introduced. X-ray contrast composition contains water-soluble iodinated contrast and water solution of antiseptic or antibiotic of wide spectrum action in standard dilution with ratio 1:1. Carrying out such diagnostics allows to achieve the most full contrasting of perforation opening and leaks in cellular tissue of mediastenum, and at the same time sanitise pyoinflammatory nidus of perforated esophagus, eliminating source of development of acute mediastenitis, and stop pain syndrome without additional use of analgetics.
EFFECT: ensuring possibility of sanitising pyoinflammatory nidus of perforated esophagus, eliminating source of development of acute mediastenitis, and stopping pain syndrome without additional use of analgetics.