Pharmaceutical composition containing cyclopeptide and chemotherapeutic agent or an inhibitor of angiogenesis

The invention relates to new derivatives of 2-aminopyridine of General formula (I)

where And denotes the radical

in which R₁, R₂and R₃mean hydrogen, halogen, HE, alkyl or alkoxy and the other,

or radical

in which R₈means hydrogen, x is the radical -(CH₂)m-Q, m is an integer from 0 to 6, Y represents alkyl, alkenylphenol or alkenylphenol chain or other, R₁₀is hydrogen or alkyl, or their salts

The invention relates to physiology, pharmacology and medicinal chemistry, in particular, to an improved method of inhibiting platelet aggregation

The invention relates to medicine, namely to experimental pharmacology and cardiology

The invention relates to cardiology and can be used to prevent reperfusion lesions of the heart after the opening of the coronary artery in patients with acute myocardial infarction

The invention relates to organic chemistry and pharmacology, namely a mixture of isomers of the potassium salt of 2-[5(6)-nitro-1-(titanyl-3)benzimidazolyl-2-thio] acetic acid in a molar ratio of 1:3, manifesting cardiotonic activity

The invention relates to the pharmaceutical industry, namely the creation of pharmaceutical compositions with a wide range of pharmacological actions on derived orotovoy acid

The invention relates to new sulfadimethoxine benzopyranones derivative of the formula I
< / BR>
where R(5) is in one of positions 5, 6, 7 and 8, and R(1) and R(2) independently of one another denote hydrogen or alkyl with 1-6 carbon atoms, R(3) means R(10)-C_nH_2nR(10) means a hydrogen atom or methyl, n denotes an integer equal to 0-10, R(4) means R(13)- C_rH_2rand one of CH₂group can be replaced by-CO-O - or-O-CO - group, R(13) denotes methyl or trifluoromethyl, r is an integer equal 0-12, R(5) means-Y-C_sH_2s-R(18), Y represents-O-, s indicates an integer equal to 1-8, R(18) denotes hydrogen, trifluoromethyl or phenyl, R(6) means-OR(10d) or-OCOR(10d) group, R(10d) denotes hydrogen or alkyl with 1-3 carbon atoms, denotes hydrogen or R(6) and together form a bond; and their physiologically acceptable salts

The invention relates to new compounds of the formula (I):

wherein R¹is phenyl, naphthyl, 1,2,3,4-tetrahydronaphthyl, (ISO)hyalinella, tetrahydro(ISO)hyalinella, 3,4-dihydro-1H-izokhinolinom, romaniam or camphor group, and these groups optionally can be substituted by one or more substituents selected from (1-8C)alkyl or (1-8C)alkoxyl; R²and R³independently are H or (1-8C)alkyl; R⁴is (1-8C)alkyl or (3-8C)cycloalkyl; or R³and R⁴together with the nitrogen atom to which they are linked, are a nonaromatic (4-8)membered cycle, optionally containing another heteroatom, the cycle is optionally substituted (1-8C)alkyl or SO₂is(1-8C)alkyl; Q is a spacer having a chain length from 10 to 70 atoms; and Z is a negatively charged oligosaccharide residue comprising from two to six monosaccharide units, the charge is compensated by positively charged counterions, or its pharmaceutically acceptable salts or prodrugs and pharmaceutical compositions having antimicrobial activity

The invention relates to organic chemistry and pharmacology, and relates new connection - 1-(1,1-dissociator-3)-2-morpholinobenzenediazonium hydrochloride, increasing resistance to acute hypoxia with hypercapnia

The invention relates to new indole derivative of the formula I

where two of R^1a, R^lb, R^lc, R^ldindependently from each other denote H, F, I, Cl, Br, (C₁-C₄)alkyl, phenyl, phenyl-(C_1-WITH₄)alkyl, (C₁-C₄)alkoxy, phenyl-(C₁-C₄)alkoxy, phenyloxy, HE, -NR^5aR^5b, -SO_n-R^6c, n is 1-2, and are the same or different, and two other mean N; where all residues R^5a, R^5b, R^6cif present in the molecule more than once, are independent from each other and may be each the same or different; one of R²and R³means -(CH₂)_p-CO-R⁸and the other denotes H, F, Cl, Br, or -(CH₂)_p-CO-R⁸; p is 0, 1 or 2; R⁸means-NR⁹R¹⁰, -OR¹⁰; A represents the bivalent residue of(C₁-C₄)alkyl, which is saturated or which contains a triple bond, or -(C₁-C₄)alkyl-CO-NH-, where the nitrogen is associated with R⁴; R⁴means phenyl, which is substituted by one residue R^15bor pyridyl, which is unsubstituted or substituted¹⁴on the nitrogen atom; all their stereozoom

The invention relates to biologically compatible carriers of oxygen for administration to patients as a Supplement or partial substitution of whole blood

The invention relates to aqueous pharmaceutical compositions of erythropoietin that are free from the products of human serum, stable amino acid, sorbitan mono-9-octadecenoate poly(oxy-1,2-ethandiyl) derived

The invention relates to the field of medicine and relates to adhesive compositions to stop bleeding on the basis of factor VIII

The invention relates to the field of pharmaceutical industry

The invention relates to new compounds of General formula I

R1-A-B-D-E_n-R2 (I)

in which R1 represents R12C(O), and R12 is selected from the group consisting of alkenyl, alkenylacyl or alkenylamine; And is a group A1-A2-A3, where A1 represents NH, A2 is a CHR93 in which R93 is 4-amidinophenoxy; A3 represents C(O); is a group B1-B2-B3, where B1 represents NH; B2 is a CHR97 where R97 represents ethyl, which is substituted in position 2 by hydroxycarbonyl or allyloxycarbonyl; B3 represents C(O); D represents a group D1-D2-D3, where D1 represents NH, D2 represents CR81R82 where R81 and R82 are independently selected from the group consisting of hydrogen and unsubstituted or substituted residues of alkyl, aryl, arylalkyl, heteroallyl; D3 represents C(O); E_nis a (E1-E2-E3)_nin which n is 0 or 1; E1 represents NR70, where R70 is H; E2 represents CR71R72, where R71 and R72 include independently selected from the group consisting of hydrogen and unsubstituted or substituted residues of alkyl, aryl, arylalkyl, heteroallyl; E3 represents C(O); R2 is a NR21R22 where R21 of iillil and geterotsiklicheskikh, moreover, the alkyl contains from 1 to 13 carbon atoms, alkenyl contains from 2 to 13 carbon atoms, aryl and heteroaryl contain from 5 to 13 ring carbon atoms, where in the rest of heteroaryl one or more carbon atoms are replaced by heteroatoms selected from the group consisting of N, O and S; heteroseksualci contains from 3 to 8 ring carbon atoms, of which from one to three carbon atoms are replaced by heteroatoms selected from the group consisting of N, O and S; in any stereoisomeric forms or their mixtures in any ratio, and their pharmaceutically acceptable salts; the method of obtaining compounds of General formula I, including linking protected amino acids; to pharmaceutical compositions which are able to exert an antithrombotic effect by activated factor VII(FVIIa) blood coagulation

The invention relates to the field of pharmaceutical industry and relates to a composition for the prevention and treatment of fibrocystic mastopathy