Derivatives accountrelated as anticoagulants, pharmaceutical composition and method of treatment

 

The present invention relates to AccountManagement derived

formula I

where a represents =CH - or =N-, m denotes the number of 1-3, n denotes the number 1-4, D represents-N(R5)-C(Z) -, or-N(R5)-S(O)p- (where p denotes 0 to 2, Z represents an oxygen atom or sulfur or N2and the nitrogen atom is directly linked to the phenyl ring containing the substituents R1and R2), E denotes-C(Z)-N(R5)- or-S(O)p-N(R5)- (where p denotes 0 to 2, Z represents an oxygen atom or sulfur or N2and the nitrogen atom may be associated with the phenyl ring containing the substituents R1and R2or aromatic ring containing substituent R4). The compounds inhibit the enzyme, factor XA, so that they can be used as anticoagulants. Also described pharmaceutical composition and method of treatment using compounds of formula I. 3 C. and 63 C.p. f-crystals.

Description text in facsimile form (see graphic part).

Claims

1. A compound selected from compounds of formula (I)

where a represents =CH - or =N-;

m=1-3;

n=1-4;

and the nitrogen atom is directly linked to the phenyl ring containing the substituents R1and R2);

E represents-C(Z)-N(R5)- or-S(O)p-N(R5)- (where p=0-2, Z represents an oxygen atom or sulfur or N2and the nitrogen atom may be associated with the phenyl ring containing the substituents R1and R2or aromatic ring containing substituent R4);

R1in each case independently denotes a hydrogen atom, halo, haloalkyl, and hydroxy;

R2denotes a hydrogen atom, alkyl, aryl, aralkyl, halo, haloalkyl, cyano, -OR5, -S(O)p-R9(where R=0-2), -C(O)OR5, -OC(O)-R5, -C(O)N(R5R6, -N(R10R11, -C(R7)H-N(R10R11, -C(R7)H-OR5, -C(R7)H-R8-OR5, -C(R7)H-S(O)p-R9(where R=0-2), -C(R7)H-R8-S(O)p-R9(where R=0-2), -O-R8-S(O)p-R9(where R=0-2), -C(R7)H-N(R5R6, -C(R7)H-R8-N(R5R6, -O-R8-CH(OH)-CH2N(R10R11, -O-R8-N(R10R11, -O-R8-OC(O)R5, -O-R8-CH(OH)-CH2-Or SIG5, -O-(R8-O)t-R5(where t=1 to 6), -O-(R8-O)t-R19(where t=1 to 6), -O-R8-C(O)R5, -O-R8-C(O)R19, -O-R8>R8-C(O)OR5(where R=0-2), or-N(R5)CH(R12)-C(O)OR5;

R3denotes a radical of the formula (i)

where r=1;

R13denotes a hydrogen atom, alkyl, halo, haloalkyl;

R14in each case independently denotes a hydrogen atom, alkyl, halo, formyl, acetyl, cyano, -R8-CN, -N(R10R11, -C(R7)H-N(R10R11, -C(R7)H-R8-N(R10R11, -C(R7)H-N(R9)(R16)2, -C(R7)H-R8-N(R9)(Rl6)2, -C(O)OR5, -C(R7)H-C(O)OR5, -C(R7)N-C(O)OR5, -OR5, -C(R7)H-OR5, -C(R7)H-R8-OR5, -C(R7)H-O-R15, -S(O)p-R15(where R=0-2), -C(R7)H-S(O)p-R15(where R=0-2), -C(R7)H-R8-S(O)p-R15(where R=0-2), -S(O)p-N(R5R6(where R=0-2), -C(O)N(R5R6, -C(R7)H-C(O)N(R5R6, -C(R7)H-R8-C(O)-N(R5R6, -C(R7)H-N(R5)(R8-O)t-R5(where t=1 to 6), -C(R7)H-R8-N(R5)-(R8-O)t-R5(where t=1 to 6), -O-R8-CH(OH)-CH2-Or SIG5, -C(R7)H-O-R8-CH(OH)-CH2OR5, -C(R7)H-N(R5)-R8-[0)-C(NR17)-N(R10R11, -C(R7)H-N(R10)-C(N-R17)-R10, -C(NR17)-N(R5R6, -C(R7)H-C(NR17)-N(R5R6; -C(R7)H-O-N(R5R6, heterocyclyl [where heterocyclyl radical is not associated with the radical of the formula (i) via a nitrogen atom and optionally substituted by alkyl, aryl, aralkyl, halo, haloalkyl, exography, -OR5-C(O)OR5, -N(R5R6or-C(O)N(R5R6] or geterotsiklicheskikh [where heterocyclyl radical is not associated with the alkyl moiety through a nitrogen atom and optionally substituted by one or more substituents selected from the group comprising alkyl, aryl, aralkyl, halo, haloalkyl, oxoprop, -OR5, -C(O)OR5, -N(R5R6and-C(O)N(R5R6], or

R3denotes a radical of the formula (ii)

where v=1-4;

R13matter listed for formula (i);

R14matter listed for formula (i);

R4in each case independently denotes a hydrogen atom, alkyl, halo, haloalkyl, cyano-, nitro-group, -OR5, -C(O)OR5, -N(R5R6, -C(O)N(R5R6or-R8-N(R5R6, R5and R6in each case, independently of the Lee alkyl, R8in each case independently denotes a straight or branched alkylenes, alkylidene or alkylidene chain, R9in each case independently denotes an alkyl, aryl or aralkyl, R10and R11each independently of one another denotes a hydrogen atom, alkyl, haloalkyl, aryl, aralkyl, formyl, cyano, -R8-CN, -OR5, -R8-OR5, -S(O)p-R15(where R=0-2), -R8-S(O)p-R15(where R=0-2), -N(R5R6, -R8-N(R5R6, -R8-C(O)OR5, -C(O)-R15, -C(O)NH2, -R8-C(O)NH2, -C(S)NH2, -C(O)-S-R5, -C(O)-N(R5R15, -R8-C(O)-N(R5R15, -C(S)-N(R5R15, -R8-N(R5)-C(O)H, -R8-N(R5)-C(O)R15, -C(O)O-R8-N(R5R6:- C[N(R5R6]=C(R18R10, -R8-N(R5)-P(O)(OR5)2cycloalkyl (optionally substituted by one or more substituents selected from the group comprising alkyl, halo and-OR5), heterocyclyl [optionally substituted by alkyl, aryl, aralkyl, halo, haloalkyl, exography, -OR5, -R8-OR5, -C(O)OR5, -S(O)-R9(where R=0-2), -R8-S(O)p-R9(where R=0-2), -N(R5R6or-C(O)N(R5R65, -R8-OR5, -C(O)OR5, -S(O)p-R9(where R=0-2), -R8-S(O)p-R9(where R=0-2), -N(R5R6and-C(O)N(R5R6], or R10and R11together with the nitrogen atom to which they are attached, form a N-heterocyclic ring containing zero to two additional heteroatoms, where N-heterocyclic ring optionally substituted by one or more substituents selected from the group comprising alkyl, halo, haloalkyl, aryl, aralkyl, oxo - nitro-, cyano, -R8-CN, =N(R17), -OR5, -C(O)OR5, -R8-C(O)OR5, -N(R5R6, -R8-N(R5R6, -C(O)N(R5R6, -R8-C(O)N(R5R6, -N(R5)N(R5R6, -C(O)R5-C(O)-(R8-O)t-R5(where t=1 to 6), -S(O)p-R9(where R=0-2), -R8-S(O)p-R9(where R=0-2), -(R8-O)t-R5(where t=1-6) and heterocyclyl [optionally substituted by one or more substituents selected from the group comprising alkyl, aryl, aralkyl, halo, haloalkyl, -OR5, -C(O)OR5, -N(R5R6and-C(O)N(R5R6],

R12denotes the side chain ofand R8-O-C(O)-R5, -R8-OR5, -N(R5R6, -R8-N(R5R6, -R8-C(O)OR5, heterocyclyl [optionally substituted by one or more substituents selected from the group comprising alkyl, aryl, aralkyl, halo, haloalkyl, -OR5, -R8-OR5, -C(O)OR5, -N(R5R6and-C(O)N(R5R6] or geterotsiklicheskikh [optionally substituted by one or more substituents selected from the group comprising alkyl, aryl, aralkyl, halo, haloalkyl, -OR5, -R8-OR5, -C(O)OR5, -N(R5R6and-C(O)N(R5R6] or

R5and R15together with the nitrogen atom to which they are attached, form a N-heterocyclic ring containing zero to two additional heteroatoms, where N-heterocyclic ring optionally substituted by one or more substituents selected from the group comprising alkyl, aryl, aralkyl, amino, monoalkylamines, dialkylamines, -OR5, -C(O)OR5aminocarbonyl, monoalkylamines-carbonyl and dialkylaminoalkyl,

R16in each case independently denotes an alkyl, aryl, aralkyl, -R8-OR5, -R8-N(R5R6cycloalkyl (optionally substituted by one or flax substituted by alkyl, the aryl, aralkyl, halo, haloalkyl, -OR5, -C(O)OR5, -N(R5R6or-C(O)N(R5R6] or geterotsiklicheskikh [optionally substituted by one or more substituents selected from the group comprising alkyl, aryl, aralkyl, halo, haloalkyl, -OR5, -C(O)OR5, -N(R5R6and-C(O)N(R5R6], or both R16together with the nitrogen atom, with cotrim they are connected and when there is no substituent R9form an aromatic N-heterocyclic ring containing zero to two additional heteroatoms, where N-heterocyclic ring optionally substituted by one or more substituents selected from the group comprising alkyl, aryl, aralkyl, -OR5, -C(O)OR5, -R8-C(O)OR5, -N(R5R6, -R8-N(R5R6, -C(O)R5, -C(O)-(R8-O)t-R5(where t=1-6) and -(R8-O)t-R5(where t=1-6), R17in each case independently denotes a hydrogen atom, alkyl, aryl, aralkyl, cyano, -OR5, -R8-OR5, -C(O)OR5, -R8-C(O)OR5, -C(O)-N(R5R6or-R8-C(O)-N(R5R6, R18denotes a hydrogen atom, alkyl, aryl, aralkyl, cyano, -C(O)OR5or NO2and R19each is, -R8-C(O)N(R5R6, heterocyclyl [optionally substituted by alkyl, aralkyl, halo, haloalkyl, -OR5, -C(O)OR5, -N(R5R6or-C(O)N(R5R6] or geterotsiklicheskikh [optionally substituted by one or more substituents selected from the group comprising alkyl, aryl, aralkyl, halo, haloalkyl, -OR5, -C(O)OR5, -N(R5R6and-C(O)N(R5R6],

where "aryl" is called a phenyl or nattily radical, optionally substituted by alkyl, halogen, -OR5(where R5means hydrogen, alkyl, aryl or aralkyl); "heterocyclic ring" is called stable 5-6-membered ring radical which consists of carbon atoms and one or two heteroatoms selected from the group comprising nitrogen, oxygen and sulfur, and nitrogen atoms or sulfur in the heterocyclic ring radical may be optionally oxidized to various oxidation States, the nitrogen atom can be optionally and stereoselectivity, and the ring radical may be partially or fully saturated or aromatic; "heterocyclyl" called heterocyclic ring radical, which is described above, except this heterocyclic LTTE which formed a stable structure;

in the form of a single stereoisomer, or mixtures thereof, or its pharmaceutically acceptable salt.

2. Connection on p. 1, in which

And represents =N-, m=1-3, n=1-4, D represents-N(R5)-C(Z) (where Z denotes an oxygen atom, sulfur or N2and R5denotes a hydrogen atom or alkyl), E denotes-C(Z)-N(R5)- (where Z denotes an oxygen atom or sulfur or N2, R5denotes a hydrogen atom or alkyl, and the nitrogen atom is linked to pyridinium ring), R1represents halo, or haloalkyl, R2represents-N(R10R11, -O-R8-S(O)p-R9(where p=0), -O-R8-C(O)OR5, -O-(R8-O)t-R5(where t=1) or-O-R8-N(R10R11where each of R5independently of one another denotes hydrogen atom or alkyl, R8in each case independently denotes a straight or branched alkylenes chain, R9denotes alkyl, R10and R11each independently of one another denotes a hydrogen atom, alkyl or-R8-O-R5(where R8denotes a straight or branched alkylenes chain, and R5denotes a hydrogen atom or alkyl), or R10and R11together with the nitrogen atom to which they are attached, form a N-heterocyclic ring containing o, 3denotes a radical of the formula (i)

where r=1;

R13represents halo;

R14denotes-C(R7)H-N(R10R11,

where R7denotes a hydrogen atom, and R10and R11together with the nitrogen atom to which they are bound, form a piperazinil, optionally substituted by one or more substituents selected from the group comprising alkyl and-C(O)R5;

R4denotes a hydrogen atom or a halo.

3. Connection on p. 2, with m=1, n=1, D represents-N(H)-C(O)-, E represents-C(O)-N(H)- (where the nitrogen atom is linked in the 2nd position with pyridinium ring), R1represents halo in the 5th position, R2represents-N(R10R11, -O-R8-S(O)p-R9(where p=0), -O-R8-C(O)OR5, -O-(R8-O)7-R5(where t=1), or

-O-R8-N(R10R11where R5in each case independently denotes a hydrogen atom, methyl or ethyl, R8in each case independently denotes a methylene, ethylene or propylene chain, R9denotes methyl or ethyl, R10and R11each independently of one another denotes a hydrogen atom, methyl, ethyl or-R8-O-R5(where R8denotes ethylene, and R5ons, form a N-heterocyclic ring containing from zero to one additional heteroatom, where N is a heterocyclic ring optionally substituted by alkyl,

R3denotes a radical of the formula (i)

where r=1,

R13denotes a chlorine atom;

R14is in the 4th position and represents-C(R7)N-N(R10R11where R7denotes a hydrogen atom, and R10and R11together with the nitrogen atom to which they are bound, form a piperazinil, optionally substituted stands or ethyl, and4is in the 5th position and represents a hydrogen atom, bromine or chlorine.

4. Connection on p. 3, in which R1denotes a chlorine atom, R2denotes-O-R8-S(O)p-R9(where p=0), -O-R8-C(O)OR5or-O-(R8-O)t-R5(where t=1 or 2), where R5in each case independently denotes a hydrogen atom, methyl or ethyl, R8in each case independently denotes a methylene, ethylene or propylene chain, R9denotes methyl or ethyl.

5. Connection on p. 6, which is selected from the group including

N-(5-chloropyridin-2-yl)-2-{{[4-[(4-methylpiperazin-1-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-(methylthio)methoxy-5-CHL is arbonyl)methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(4-methylpiperazin-1-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-(2-hydroxyethoxy)-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(4-methylpiperazin-1-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-(2-methoxyethoxy)-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(4-methylpiperazin-1-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-(2-ethoxyethoxy)-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(4-ethylpiperazin-1-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-(2-methoxyethoxy)-5-chlorobenzamide and

N-(5-chloropyridin-2-yl)-2-{{[4-[(4-ethylpiperazin-1-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-(2-(2-methoxyethoxy)ethoxy)-5-chlorobenzamide.

6. Connection on p. 3, in which R1denotes a chlorine atom, R2represents-N(R10R11or-O-R8-N(R10R11where R8denotes a methylene, ethylene or propylene chain, and R10and R11each independently of one another denotes a hydrogen atom, methyl, ethyl or-R8-O-R5(where R8denotes ethylene, and R5denotes the hydrogen atom, the methyl or ethyl).

7. Connection on p. 6, which is selected from the group including

N-(5-chloropyridin-2-yl)-2-{{[4-[(4-methylpiperazin-1-yl)methyl]-3-chlorothiophene-2-yl] carbonyl}amino}-3-(dimethyl)amino-5-harbe the hydroxyethyl) amino]propoxy}-5-chlorobenzamide and

N-(5-chloropyridin-2-yl)-2-{{[4-[(4-methylpiperazin-1-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-amino-5-chlorobenzamide.

8. Connection on p. 3, in which R1denotes a chlorine atom, R2represents-N(R10R11or-O-R8-N(R10R11where R8denotes a methylene, ethylene or propylene, and R10and R11together with the nitrogen atom to which they are attached, form a N-heterocyclic ring containing from zero to one additional heteroatom, where N is a heterocyclic ring optionally substituted by alkyl and is selected from the group including morpholinyl, piperazinil, pyrrolidinyl and imidazolyl.

9. Connection on p. 8, which is selected from the group including

N-(5-chloropyridin-2-yl)-2-{{[4-[(4-methylpiperazin-1-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-(morpholine-4-yl)-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(4-methylpiperazin-1-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-(methylpiperazin-1-yl)-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(4-methylpiperazin-1-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-(3-morpholinoethoxy)-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(4-methylpiperazin-1-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-[3-(pyrrolidin-1-yl)propoxy]-5-chlorobenzamide,

N-(5-chloropyridin-chloropyridin-2-yl)-2-{{[4-[(4-methylpiperazin-1-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-[3-(imidazol-1-yl)propoxy]-5-chlorobenzamide and

N-(5-chloropyridin-2-yl)-2-{{[4-[(4-ethylpiperazin-1-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3- (morpholine-4-yl)-5-chlorobenzamide.

10. Connection on p. 1, And which represents =N-, m=1-3, n=1-4, D represents-N(R5)-C(Z) (where Z denotes an oxygen atom or sulfur or N2, a R5denotes a hydrogen atom or alkyl), E denotes-C(Z)-N(R5)- (where Z denotes an oxygen atom or sulfur or N2, R5denotes a hydrogen atom or alkyl, and the nitrogen atom is linked to pyridinium ring), R1represents halo, or haloalkyl, R2denotes a hydrogen atom, haloalkyl or5where R5denotes a hydrogen atom or alkyl, R3denotes a radical of the formula (i)

where r=1;

R13represents halo;

R14in each case independently denotes a hydrogen atom, alkyl, halo, formyl, acetyl, cyano, -R8-CN, -N(R10R11, -C(R7)H-N(R10R11, -C(R7)H-R8-N(R10R11, -C(R7)H-N(R9)(R16)2, -C(R7)H-R8-N(R9)(R16)2, -C(O)OR5, -C(R7)H-C(O)OR5, -C(R7)H-R8-C(O)OR5, -OR5, -C(R7)H-OR5, -C(R7)H-R7)H-R8-S(O)p-R15(where R=0-2), -S(O)p-N(R5R6(where R=0-2), -C(O)N(R5R6, -C(R7)H-C(O)N(R5R6, -C(R7)H-R8-C(O)N(R5R6, -C(R7)H-N(R5)-(R8-O)t-R5(where t=1 to 6), -C(R7)H-R8-N(R5)-(R8-O)t-R5(where t=1 to 6), -O-R8-CH(OH)-CH2-Or SIG5, -C(R7)H-O-R8-CH(OH)-CH2-OR5, -C(R7)H-N(R5)-R8-[CH(OH)]t-CH2-Or SIG5(where t=1 to 6), -C(R7)H-N(R5)-S(O)2-N(R10R11, -C(R7)H-N(R10)-C(NR17)N(R10R11, -C(R7)H-N(R10)-C(N-R17)-R10, -C(NR17)-N(R5R6, -C(R7)H-C(NR17)-N(R5R6, -C(R7)H-O-N(R5R6, heterocyclyl [where heterocyclyl radical is not associated with the radical of the formula (i) via a nitrogen atom and optionally substituted by alkyl, aryl, aralkyl, halo, haloalkyl, exography, -OR5, -C(O)OR5, -N(R5R6or-C(O)N(R5R6] or geterotsiklicheskikh [where heterocyclyl radical is not associated with the alkyl moiety through a nitrogen atom and optionally substituted by one or more substituents selected from the group comprising alkyl, aryl, aralkyl, halo, haloalkyl, oxoprop from each other represents a hydrogen atom, alkyl, aryl or aralkyl, R7in each case independently denotes a hydrogen atom or alkyl, R8in each case independently denotes a straight or branched alkylenes, alkylidene or alkylidene chain, R9in each case independently denotes an alkyl, aryl or aralkyl, R10and R11each independently of one another denotes a hydrogen atom, alkyl, haloalkyl, aryl, aralkyl, formyl, cyano, -R8-CN, -OR5, -R8-OR5, -S(O)p-R15(where R=0-2), -R8-S(O)p-R15(where R=0-2), -N(R5R6, -R8-N(R5R6, -R8-C(O)OR5, -C(O)-R15, -C(O)NH2, -R8-C(O)NH2, -C(S)NH2, -C(O)-S-R5, -C(O)-N(R5R15, -R8-C(O)-N(R5R15, -C(S)-N(R5R15, -R8-N(R5)-C(O)H, -R8-N(R5)-C(O)R15, -C(O)O-R8-N(R5R6:- C[N(R5R6]=C(R18R10, -R8-N(R5)-P(O)(OR5)2cycloalkyl (optionally substituted by one or more substituents selected from the group comprising alkyl, halo and-OR5), heterocyclyl [optionally substituted by alkyl, aryl, aralkyl, halo, haloalkyl, exography, -OR5, -R8-OR5, -C(O)OR5, -S(O) is geterotsiklicheskikh [optionally substituted by one or more substituents, selected from the group comprising alkyl, aryl, aralkyl, halo, haloalkyl, oxoprop, -OR5, -R8-OR5, -C(O)OR5, -S(O)p-R9(where R=0-2), -R8-S(O)p-R9(where R=0-2), -N(R5R6and-C(O)N(R5R6], where R5and R6each independently of one another denotes a hydrogen atom, alkyl, aryl or aralkyl, R8in each case independently denotes a straight or branched alkylenes, alkylidene or alkylidene chain,

R9in each case independently denotes an alkyl, aryl or aralkyl,

R15in each case independently denotes an alkyl, cycloalkyl, haloalkyl, aryl, aralkyl, -R8-OC(O)-R5, -R8-OR5, -N(R5R6, -R8-N(R5R6, -R8-C(O)OR5, heterocyclyl [optionally substituted by one or more substituents selected from the group comprising alkyl, aryl, aralkyl, halo, haloalkyl, -OR5, -R8-OR5, -C(O)OR5, -N(R5R6and-C(O)N(R5R6] or geterotsiklicheskikh [optionally substituted by one or more substituents selected from the group comprising alkyl, aryl, aralkyl, halo, haloalkyl, -OR5, -R8-OR5, -C(O)OR5, -N(R5R6the keel, aryl or aralkyl, and R8in each case independently denotes a straight or branched alkylenes, alkylidene or alkylidene chain, or R5and R15together with the nitrogen atom to which they are attached, form a N-heterocyclic ring containing zero to two additional heteroatoms, where N-heterocyclic ring optionally substituted by one or more substituents selected from the group comprising alkyl, aryl, aralkyl, amino, monoalkylamines, dialkylamines, -OR5-C(O)OR5aminocarbonyl, monoalkylamines and dialkylaminoalkyl, where R5in each case denotes hydrogen atom, alkyl, aryl or aralkyl, and R18denotes a hydrogen atom, alkyl, aryl, aralkyl, cyano, -C(O)OR5or NO2or R10and R11together with the nitrogen atom to which they are attached, form a N-heterocyclic ring containing zero to two additional heteroatoms, where N-heterocyclic ring optionally substituted by one or more substituents selected from the group comprising alkyl, halo, haloalkyl, aryl, aralkyl, oxo, nitro, cyano, -R8-CN, =N(R17), -OR5, -C(O)OR5, -R8-C(O)OR5, -N(R5)R< R6, -C(O)R5, -C(O)-(R8-O)t-R5(where t=1 to 6), -S(O)p-R9(where R=0-2), -R8-S(O)p-R9(where R=0-2), -(R8-O)t-R5(where t=1-6) and heterocyclyl [optionally substituted by one or more substituents selected from the group comprising alkyl, aryl, aralkyl, halo, haloalkyl, -OR5, -C(O)OR5, -N(R5R6and-C(O)N(R5R6], where R5and R6each independently of one another denotes a hydrogen atom, alkyl, aryl or aralkyl, R8in each case independently denotes a straight or branched alkylenes, alkylidene or alkylidene chain, R9in each case independently denotes an alkyl, aryl or aralkyl, R17in each case independently denotes a hydrogen atom, alkyl, aryl, aralkyl, cyano, -OR5, -R8-OR5, -C(O)OR5, -R8-C(O)OR5-C(O)-N(R5R6or-R8-C(O)-N(R5R6where R5and R6each independently of one another denotes a hydrogen atom, alkyl, aryl or aralkyl, and R8in each case independently denotes a straight or branched alkylenes, alkylidene or alkylidene chain, R16in each case independently denotes an alkyl, aryl, aralkyl, -R85), heterocyclyl [optionally substituted by alkyl, aryl, aralkyl, halo, haloalkyl, -OR5, -C(O)OR5, -N(R5R6or-C(O)N(R5R6] or geterotsiklicheskikh [optionally substituted by one or more substituents selected from the group comprising alkyl, aryl, aralkyl, halo, haloalkyl, -OR5, -C(O)OR5, -N(R5R6and-C(O)N(R5R6], where R5and R6each independently of one another denotes a hydrogen atom, alkyl, aryl or aralkyl, and R8in each case independently denotes a straight or branched alkylenes, alkylidene or alkylidene chain, or both R16together with the nitrogen atom to which they relate (and when there is no substituent R9form an aromatic N-heterocyclic ring containing zero to two additional heteroatoms, where N-heterocyclic ring optionally substituted by one or more substituents selected from the group comprising alkyl, aryl, aralkyl, -OR5, -C(O)OR5, -R8-C(O)OR5, -N(R5R6, -R8-N(R5R6, -C(O)R5, -C(O)-(R8-O)t-R5(where t=1-6) and -(R8-O)t-R58in each case independently denotes a straight or branched alkylenes, alkylidene or alkylidene chain,

R17in each case independently denotes a hydrogen atom, alkyl, aryl, aralkyl, cyano, -OR5, -R8-OR5, -C(O)OR5, -R8-C(O)or SIG5-C(O)-N(R5R6or-R8-C(O)-N(R5R6where R5and R6each independently of one another denotes a hydrogen atom, alkyl, aryl or aralkyl, and R8in each case independently denotes a straight or branched alkylenes, alkylidene or alkylidene chain, and R4denotes a hydrogen atom or a halo.

11. Connection on p. 10, in which m=1, n=1, D represents-N(H)-C(O)-, E represents-C(O)-N(H)- (where the nitrogen atom is attached to pyridinoline ring in the 2nd position), R2denotes a hydrogen atom, haloalkyl or5where R5denotes a hydrogen atom or alkyl,

R3denotes a radical of the formula (i)

where r=1; R13represents halo; and

R14denotes-C(R7)H-N(R10R11where R7denotes a hydrogen atom, R10and R11each independently of one another denotes a hydrogen atom, alkyl, haloalkyl, aryl, ar is sub>p
-R15(where R=0-2), -N(R5R6, -R8-N(R5R6, -R8-C(O)OR5, -C(O)-R15, -C(O)NH2, -R8-C(O)NH2, -C(S)NH2, -C(O)-S-R5, -C(O)-N(R5R15, -R8-C(O)N(R5R15, -C(S)-N(R5Rl5, -R8-N(R5)-C(O)H, -R8-N(R5)-C(O)R15, -C(O)O-R8-N(R5R6,- [N(R5R6]=C(R18R10, -R8-N(R5)-P(O)(OR5)2cycloalkyl (optionally substituted by one or more substituents selected from the group comprising alkyl, halo and-OR5), heterocyclyl [optionally substituted by alkyl, aryl, aralkyl, halo, haloalkyl, exography, -OR5, -R8-OR5, -C(O)OR5, -S(O)p-R9(where R=0-2), -R8-S(O)p-R9(where R=0-2), -N(R5R6or-C(O)N(R5R6] or geterotsiklicheskikh [optionally substituted by one or more substituents selected from the group comprising alkyl, aryl, aralkyl, halo, haloalkyl, oxoprop, -OR5, -R8-OR5, -C(O)OR5, -S(O)p-R9(where R=0-2), -R8-S(O)p-R9(where R=0-2), -N(R5R6and-C(O)N(R5R6], where R5and R6each independently of one another denotes a hydrogen atom, alkylidene or alkylidene chain, R9in each case independently denotes an alkyl, aryl or aralkyl, R15in each case independently denotes an alkyl, cycloalkyl, haloalkyl, aryl, aralkyl, -R8-O-C(O)-R5, -R8-OR5, -N(R5R6, -R8-N(R5R6, -R8-C(O)OR5, heterocyclyl [optionally substituted by one or more substituents selected from the group comprising alkyl, aryl, aralkyl, halo, haloalkyl, -OR5, -R8-OR5, -C(O)OR5, -N(R5R6and-C(O)N(R5R6] or geterotsiklicheskikh [optionally substituted by one or more substituents selected from the group comprising alkyl, aryl, aralkyl, halo, haloalkyl, -OR5, -R8-OR5, -C(O)OR5, -N(R5R6and -(O)N(R5R6], where R5and R6each independently of one another denotes a hydrogen atom, alkyl, aryl or aralkyl, and R8in each case independently denotes a straight or branched alkylenes, alkylidene or alkylidene chain, or R5and R15together with the nitrogen atom to which they are attached, form a N-heterocyclic ring containing zero to two additional heteroatoms, where N-heterocyclic ring optionally, salmenlinna-, dialkylamino, -OR5, -C(O)OR5aminocarbonyl, monoalkylamines and dialkylaminoalkyl, where R5in each case denotes hydrogen atom, alkyl, aryl or aralkyl, and R18denotes a hydrogen atom, alkyl, aryl, aralkyl, cyano, -C(O)OR5or NO2or R10and R11together with the nitrogen atom to which they are attached, form a N-heterocyclic ring containing zero to two additional heteroatoms, where N-heterocyclic ring optionally substituted by one or more substituents selected from the group comprising alkyl, halo, haloalkyl, aryl, aralkyl, oxo, nitro, cyano, -R8-CN, =N(R17), -OR5, -C(O)OR5, -R8-C(O)OR5, -N(R5R6, -R8-N(R5R6, -C(O)N(R5R6, -R8-C(O)N(R5R6, -N(R5)-N(R5R6, -C(O)R5-C(O)-(R8-O)t-R5(where t=1-6), S(O)p-R9(where R=0-2), -R8-S(O)p-R9(where R=0-2), -(R8-O)t-R5(where t=1-6) and heterocyclyl [optionally substituted by one or more substituents selected from the group comprising alkyl, aryl, aralkyl, halo, haloalkyl, -OR5, -C(O)OR5, -N(R5R6and-C(O)N(R5)R8in each case independently denotes a straight or branched alkylenes, alkylidene or alkylidene chain, R9in each case independently denotes an alkyl, aryl or aralkyl,

R17in each case independently denotes a hydrogen atom, alkyl, aryl, aralkyl, cyano, -OR5, -R8-OR5, -C(O)OR5, -R8-C(O)OR5-C(O)-N(R5R6or-R8-C(O)N(R5R6where R5and R6each independently of one another denotes a hydrogen atom, alkyl, aryl or aralkyl, and R8in each case independently denotes a straight or branched alkylenes, alkylidene or alkylidene chain and R4is in the 5th position.

12. Connection on p. 11, in which R10and R11each independently of one another denotes a hydrogen atom, alkyl, haloalkyl, aryl, aralkyl, formyl, cyano, -R8-CN, -OR5, -R8-OR5, -S(O)p-R15(where R=0-2), -R8-S(O)p-R15(where R=0-2), -N(R5R6, -R8-N(R5R6, -R8-C(O)OR5, -C(O)-R15, -C(O)NH2, -R8-C(O)NH2, -C(S)NH2, -C(O)-S-R5-C(O)-N(R5R15, -R8-C(O)-N(R5R15, -C(S)-N(R5R15, -R8-N(R5-R8-N(R5)-P(O)(OR5)2cycloalkyl (optionally substituted by one or more substituents selected from the group comprising alkyl, halo and-OR5), heterocyclyl [optionally substituted by alkyl, aryl, aralkyl, halo, haloalkyl, exography, -OR5, -R8-OR5, -C(O)OR5, -S(O)p-R9(where R=0-2), -R8-S(O)p-R9(where R=0-2), -N(R5R6or-C(O)N(R5R6] or geterotsiklicheskikh [optionally substituted by one or more substituents selected from the group comprising alkyl, aryl, aralkyl, halo, haloalkyl, oxoprop, -OR5, -R8-OR5, -C(O)OR5, -S(O)p-R9(where R=0-2), -R8-S(O)p-R9(where R=0-2), -N(R5R6and-C(O)N(R5R6], where R5and R6each independently of one another denotes a hydrogen atom, alkyl, aryl or aralkyl, R8in each case independently denotes a straight or branched alkylenes, alkylidene or alkylidene chain, R9in each case independently denotes an alkyl, aryl or aralkyl, R15in each case independently denotes an alkyl, cycloalkyl, haloalkyl, aryl, aralkyl, -R8-OC(O)-R5, -R8-OR5, -N(R5R6, -R5, -R8-OR5, -C(O)OR5, -N(R5R6and-C(O)N(R5R6] or geterotsiklicheskikh [optionally substituted by one or more substituents selected from the group comprising alkyl, aryl, aralkyl, halo, haloalkyl, -OR5, -R8-OR5, -C(O)OR5, -N(R5R6and-C(O)N(R5R6]

R5and R6each independently of one another denotes a hydrogen atom, alkyl, aryl or aralkyl, and R8in each case independently denotes a straight or branched alkylenes, alkylidene or alkylidene chain, or R5and R15together with the nitrogen atom to which they are attached, form a N-heterocyclic ring containing zero to two additional heteroatoms, where N-heterocyclic ring optionally substituted by one or more substituents selected from the group comprising alkyl, aryl, aralkyl, amino, monoalkylamines, dialkylamines, -OR5-C(O)OR5aminocarbonyl, monoalkylamines and dialkylaminoalkyl, where R5in each case independently denotes a hydrogen atom, alkyl, aryl or aralkyl and R18denotes the atom sup> denotes a hydrogen atom, alkyl or-R8-OR5and R11denotes a hydrogen atom, alkyl or-R8-OR5where R8in each case independently denotes a straight or branched alkylenes chain, and R5in each case denotes hydrogen atom or alkyl.

14. Connection on p. 13, which is selected from the group including

N-(5-chloropyridin-2-yl)-2-{[[4-(chloromethyl)-3-chlorothiophene-2-yl]carbonyl]amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(N'-methyl-N'-(2-hydroxyethyl)amino)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(N'-methyl-N'-(2-hydroxyethyl)amino)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-hydroxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(N',N'-di(2-hydroxypropyl)-amino)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(N'-methyl-N'-(3-hydroxypropyl)amino)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-1(N'-methyl-N'-(2-hydroxypropyl)amino)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(N'-ethyl-N'-(2-hydroxyethyl)amino)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)

N-(5-chloropyridin-2-yl)-2-{{[4-[(N'-methyl-N'-(2-hydroxyethyl)amino)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-ethoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[((2-hydroxyethyl)amino)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(methylamino)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-(amino)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(dimethylamino)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(N'-ethyl-N'-methylamino)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(N'-(1-methylethyl)amino)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-(ethylamino)methyl-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide and

N-(5-chloropyridin-2-yl)-2-{{[4-(diethylamino)methyl-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide.

15. Connection on p. 12, in which R10denotes a hydrogen atom, alkyl or-R8-N(R5R6, a R11represents-S(O)p-R15(where R=0-2), or-R8-N(R5R6where R5and R6each nezavisni branched alkylenes, alkylidene or alkylidene chain, and R15in each case independently denotes an alkyl, cycloalkyl, haloalkyl, aryl, aralkyl, -R8-OC(O)-R5, -R8-OR5, -N(R5R6, -R8-N(R5R6, -R8-C(O)OR5, heterocyclyl [optionally substituted by one or more substituents selected from the group comprising alkyl, aryl, aralkyl, halo, haloalkyl, -OR5, -R8-OR5, -C(O)OR5, -N(R5R6and-C(O)N(R5R6] or geterotsiklicheskikh [optionally substituted by one or more substituents selected from the group comprising alkyl, aryl, aralkyl, halo, haloalkyl, -OR5, -R8-OR5, -C(O)OR5, -N(R5R6and-C(O)N(R5R6], where R5and R6each independently of one another denotes a hydrogen atom, alkyl, aryl or aralkyl, and R8in each case independently denotes a straight or branched alkylenes, alkylidene or alkylidene chain.

16. Connection on p. 15, which is selected from the group including

N-(5-chloropyridin-2-yl)-2-{{[4-[[N'-methyl-N'-(3-(dimethylamino)propyl)amino]methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[[N'-methyl-N'-(methylsulphonyl)am methylamino)ethyl)amino]methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-hydroxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[[N'-(methyl)sulfonyl-N'(2-(dimethylamino)ethyl)amino]methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[[N'-methyl-N'-(2-(dimethylamino)ethyl)amino]methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[[N'-methyl-N'-((3,5-dimethylisoxazol-4-yl)sulfonyl)amino]methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[[N'-methyl-N'-(methylsulfonyl)amino]methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-hydroxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[[N'-methyl-N'-((2-(4-hydroxypiperidine-1-yl)ethyl)sulfonyl)amino]methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[[N'-methyl-N'-((2-(pyrrolidin-1-yl)ethyl)sulfonyl)amino]methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[[N'-methyl-N'-((dimethylamino)sulfonyl)amino]methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[[N'-(2-(aminoethyl)amino]methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide and

N-(5-chloropyridin-2-yl)-2-{{[4-[[N'-ethyl-N'-(4-(dimethylamino)but-3-in-2-yl)amino]methyl]-3-chlorothiophene-2-yl]carbonyl}amino)-3-methoxy-5-chlorbenzol denotes formyl, cyano, -C(O)-R15-C(O)NH2, -C(S)NH2, -C(O)-S-R5, -C(O)-N(R5R15, -C(S)-N(R5R15, -R8-N(R5)-P(O)(OR5)2or-C[N(R5R6]=C(R18R10where R5in each case denotes hydrogen atom or alkyl, R8denotes a straight or branched alkylenes chain, R15in each case independently denotes an alkyl, cycloalkyl, haloalkyl, aryl, aralkyl, -R8-OC(O)-R5, -R8-OR5, -N(R5R6, -R8-N(R5R6, -R8-C(O)OR5, heterocyclyl [optionally substituted by one or more substituents selected from the group comprising alkyl, aryl, aralkyl, halo, haloalkyl, -OR5, -R8-OR5, -C(O)OR5, -N(R5R6and-C(O)N(R5R6] or geterotsiklicheskikh [optionally substituted by one or more substituents selected from the group comprising alkyl, aryl, aralkyl, halo, haloalkyl, -OR5, -R8-OR5, -C(O)OR5, -N(R5R6and-C(O)N(R5R6], where R5and R6each independently of one another denotes a hydrogen atom, alkyl, aryl or aralkyl, R8in each case independently denotes a straight or branched what Il, the cyano, -C(O)OR5or NO2.

18. Connection on p. 17, which is selected from the group including

N-(5-chloropyridin-2-yl)-2-{{[4-[(N'-methyl-N"-ethylurea)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide

N-(5-chloropyridin-2-yl)-2-[{[4-[(N'-methyl-N-(2-carboxyethyl)ureido)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[[N'-methyl-N'-((4-(2-hydroxyethyl)piperazine-1-yl)carbonyl)amino]methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[[N'-methyl-N-(2-(morpholine-4-yl)ethyl)touraid]methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[[N'-methyl-N'-(((4-hydroxypiperidine-1-yl)methyl)carbonyl)amino]methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[[N'-methyl-N'-(2-hydroxyethyl)ureido]methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-(N'-methylurea)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(N'-(2-hydroxyethyl)ureido)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[[N'-methyl-N-(2-(chloro)ethyl)ureido]methyl]Il)ureido]methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[[N'-methyl-N-(2-(pyrrolidin-1-yl)ethyl)ureido]methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[[N-(2-(chloro)ethyl)ureido]methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{{4-[[N'-methyl-N"-[2-(((2-hydroxyphenyl)carbonyl)oxy)ethyl]ureido]methyl]-3-chlorothiophene-2-yl}carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(N'-methyl-N"-cyanoimino)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide

N-(5-chloropyridin-2-yl)-2-{{[4-[[N'-methyl-(2-(((permitil-carbonyl)amino)ethyl)amino]methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[[N'-methyl-N'-((2-aminoethoxy)carbonyl)amino]methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[[N'-methyl-N'-((methylthio)carbonyl)amino]methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[[N'-ethyl-N'-((phenylthio)carbonyl)amino]methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[[N'-methyl-N'-(2-nitro-1-(methylamino)ethynyl)amino]methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide and

N-(5-chloropyridin-2-yl)-2-{{[4-[[(2-dimethy is 12, in which R10denotes a hydrogen atom, alkyl or-R8-OR5, R11denotes cycloalkyl (optionally substituted by one or more substituents selected from the group comprising alkyl, halo and-OR5), heterocyclyl [optionally substituted by alkyl, aryl, aralkyl, halo, haloalkyl, exography, -OR5, -R8-OR5, -C(O)OR5, -S(O)p-R9(where R=0-2), -R8-S(O)pR9(where R=0-2), -N(R5R6or-C(O)N(R5R6] or geterotsiklicheskikh [optionally substituted by one or more substituents selected from the group comprising alkyl, aryl, aralkyl, halo, haloalkyl, oxoprop, -OR5, -R8-OR5, -C(O)OR5, -S(O)p-R9(where R=0-2), -R8-S(O)p-R9(where R=0-2), -N(R5R6and-C(O)N(R5R6], where R5and R6each independently of one another denotes a hydrogen atom, alkyl, aryl or aralkyl, R8in each case independently denotes a straight or branched alkylenes, alkylidene or alkylidene chain, R9in each case independently denotes an alkyl, aryl or aralkyl, R15in each case independently denotes an alkyl, cycloalkyl, haloalkyl, aryl, aralkyl, -Reroticly [optionally substituted by one or more substituents, selected from the group comprising alkyl, aryl, aralkyl, halo, haloalkyl, -OR5, -R8-OR5, -C(O)OR5, -N(R5R6and-C(O)N(R5R6] or geterotsiklicheskikh [optionally substituted by one or more substituents selected from the group comprising alkyl, aryl, aralkyl, halo, haloalkyl, -OR5, -R8-OR5, -C(O)OR5, -N(R5R6and-C(O)N(R5R6], where R5and R6each independently of one another denotes a hydrogen atom, alkyl, aryl or aralkyl, and R8in each case independently denotes a straight or branched alkylenes, alkylidene or alkylidene chain.

20. Connection on p. 19, which is selected from the group including

N-(5-chloropyridin-2-yl)-2-{{[4-[[N'-(2-(morpholine-4-yl)ethyl)amino]methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[[N'-methyl-N'-(2-(pyrrolidin-1-yl)ethyl)amino]methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[[N'-methyl-N'-(1-methylpiperidin-4-yl)amino]methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-hydroxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[[N'-methyl-N'-(4-hydroxycyclohexyl)amino]methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

arbennig,

N-(5-chloropyridin-2-yl)-2-{{[4-[[N'-methyl-N'-(oxazoline-2-yl)amino]methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[[N'-methyl-N'-(thiazolin-2-yl)amino]methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[[N'-ethyl-N'-(oxazoline-2-yl)amino]methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[[N'-ethyl-N'-(thiazolin-2-yl)amino]methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[N'-methyl-N'-(4-(oxo)oxazoline-2-yl)amino]methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[[N'-methyl-N'-(pyridine-2-yl)amino]methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[[N'-methyl-N'-(dihydro(4H)-1,3-oxazin-2-yl)amino]methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[[N'-methyl-N'-(oxazoline-2-yl)amino]methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[[N'-methyl-N'-(oxazoline-2-yl)amino]methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-hydroxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[[N'-(tert-butyl)-N'-(oxazoline-2-yl)amino]methyl]-3-chlorothiophene-2-yl]carbonyl}am the Mino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(N'-(2-methoxyethyl)-N'(oxazoline-2-yl)amino]methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[N'-methyl-N'-(oxazol-2-yl)-amino]methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[[N'-methyl-N'-(4-trifluoromethyl-5-(methoxycarbonyl)pyrimidine-2-yl)amino]methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[[N'-ethyl-N'-(dihydro(4H)-1,3-oxazin-2-yl)amino]methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[[N'-methyl-N'-(5-methyloxiran-2-yl)amino]methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[N'-methyl-R'-(tetrazol-5-yl)amino]methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[[N'-ethyl-N'-(tetrazol-5-yl)amino]methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[[N'-ethyl-N'-(4-methyloxiran-2-yl)amino]methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[[N'-(pyrazole-3-yl)amino]methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide

N-(5-chloropyridin-2-yl)-2-{{[4[[N'-(2,2,2-triptorelin)-N'-(oxaz-etoxycarbonyl)oxazoline-2-yl)amino]methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[[N'-(3,4-dihydro-2H-pyrrol-5-yl)amino]methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[[N'-(1,2,4-triazole-4-yl)amino]methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[[N'-methyl-N'-(3,4-dihydro-2H-pyrrol-5-yl)amino]methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[[N'-methyl-N'-(pyridine-4-yl)amino]methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[[N'-methyl-N'-(2-amino-6-methylpyrimidin-4-yl)amino]methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[[N'-methyl-N'-((1,2,4-oxadiazol-3-yl)methyl)amino]methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[[N'-(2-(imidazol-4-yl)ethyl)amino]methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[[N'-methyl-N'-(3,4,5,6-tetrahydropyridine-2-yl)amino]methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[[N'-methyl-N'-(2-chloropyrimidine-4-yl)amino]methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[[N'-ethyl-N'-((imidazol-2-yl)methyl)aminopyridin-2-yl)amino]methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[[N'-(4-aminopyrimidine-2-yl)amino]methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[[N'-(4-(methylamino)pyrimidine-2-yl)amino]methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[[N'-methyl-N'-(3-(methoxymethyl)-1,2,4-oxadiazol-5-yl)methyl)amino]methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[[N'-methyl-N'-((3-((methylthio)methyl)-1,2,4-oxadiazol-5-yl)methyl)amino]methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide and

N-(5-chloropyridin-2-yl)-2-{{[4-[[N'-methyl-N'-(1,2,3-dioxaborolan-2-yl)amino]methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide.

21. Connection on p. 11, in which R10and R11together with the nitrogen atom to which they are attached, form a N-heterocyclic ring containing zero to two additional heteroatoms, where N-heterocyclic ring optionally substituted by one or more substituents selected from the group comprising alkyl, halo, haloalkyl, aryl, aralkyl, oxo, nitro, cyano, -R8-CN, =N(R17), -OR5, -C(O)OR5, -R8-C(O)OR5, -N(R5R6, -R8-N(R5R6, -C(O)N(R5R6p-R9(where R=0-2), -R8-S(O)p-R9(where R=0-2), -(R8-O)t-R5(where t=1-6) and heterocyclyl [optionally substituted by one or more substituents selected from the group comprising alkyl, aryl, aralkyl, halo, haloalkyl, -OR5, -C(O)OR5, -N(R5R6and-C(O)N(R5R6], where R5and R6each independently of one another denotes a hydrogen atom, alkyl, aryl or aralkyl, R8in each case independently denotes a straight or branched alkylenes, alkylidene or alkylidene chain, R9in each case independently denotes an alkyl, aryl or aralkyl, R17in each case independently denotes a hydrogen atom, alkyl, aryl, aralkyl, cyano, -OR5, -R8-OR5, -C(0)OR5, -R8-C(O)OR5, -C(O)-N(R5R6or-R8-C(O)-N(R5R6where R5and R6each independently of one another denotes a hydrogen atom, alkyl, aryl or aralkyl, and R8in each case independently denotes a straight or branched alkylenes, alkylidene or alkylidene chain.

22. Connection on p. 21, in which the N-heterocyclic ring optionally substituted by one or more substituents, wibroe selected from the group including

N-(5-chloropyridin-2-yl)-2-{{[4-[(4,5-dihydropyrazol-1-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(imidazol-1-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(morpholine-4-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(pyrazole-1-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(the as-3-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(1,4,5,6-tetrahydropyrimidin-1-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(imidazolin-1-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(pyrrolidin-1-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(2,3,4,5,6,7-hexahydro-3,7-dimethyl-2,6-dioxo-1H-purine-1-yl)methyl]-3-chlorothiophene-2-yl]-carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(4-methylpiperazin-1-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(4-methylpiperazin-1-yl)methyl]-3-CHL]-3-chlorothiophene-2-yl]carbonyl}amino}-5-chlorobenzamide,

N-(pyridine-2-yl)-2-{{[4-[(4-methylpiperazin-1-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-5-chlorobenzamide,

N-(5-bromopyridin-2-yl)-2-{{[4-[(4-methylpiperazin-1-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(4-ethylpiperazin-1-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(2-Mei-1-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(4-Mei-1-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(5-Mei-1-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(2-methylimidazol-1-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide

N-(5-chloropyridin-2-yl)-2-{[[4-[(2,4-dimethylimidazole-1-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(2,5-dimethylimidazole-1-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(2-methyl-4-nitroimidazol-1-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(4,5-dichloroimidazole-1-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-Nile}amino}-3-methoxy-5-chlorobenzamide and

N-(5-chloropyridin-2-yl)-2-{{[4-[(2-(permitil)imidazolin-1-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide.

24. Connection on p. 21, in which the N-heterocyclic ring substituted by one or more substituents selected from the group comprising alkyl, a nitrogroup, -R8-CN, -OR5, -N(R5)-N(R5R6, -C(O)R5, -S(O)p-R9(where R=0-2), -(R8-O)t-R5(where t=1-6) and heterocyclyl [optionally substituted by one or more substituents selected from the group comprising alkyl, aryl, aralkyl, halo, haloalkyl, -OR5, -C(O)OR5, -N(R5R6and-C(O)N(R5R6], where R5and R6each independently of one another denotes a hydrogen atom, alkyl, aryl or aralkyl, R8in each case independently denotes a straight or branched alkylenes, alkylidene or alkylidene chain, R9in each case independently denotes an alkyl, aryl or aralkyl.

25. Connection on p. 24, which is selected from the group including

N-(5-chloropyridin-2-yl)-2-{{[4-[(4-(hydroxymethyl)imidazol-1-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[5-(hydroxymethyl)imidazol-1-yl]-3-chlorothiophene-2-yl]carbonyl}aminocarbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(2-(hydroxymethyl)imidazol-1-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-[{[4-[(4-formylpiperazine-1-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide

N-(5-chloropyridin-2-yl)-2-{{[4-(2-(N'-amino-N'-methylamino)imidazolin-1-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(4-hydroxypiperidine-1-yl)methyl]-3-chlorothiophene-2-yl]carbonyl]amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(2-(methylthio)imidazolin-1-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(4-(methylsulphonyl)piperazine-1-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(2-methyl-4-nitroimidazol-1-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(2-(cyanomethyl)imidazolin-1-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide and

N-(5-chloropyridin-2-yl)-2-{{[4-[(4-(pyrimidine-2-yl)piperazine-1-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide.

26. Connection on p. 21, in which the N-heterocyclic ring substituted by one or more substituents, select the up>, -(R8-O)t-R5and heterocyclyl [optionally substituted by one or more substituents selected from the group comprising alkyl, aryl, aralkyl, halo, haloalkyl, -OR5, -C(O)OR5, -N(R5R6and-C(O)N(R5R6], where R5and R6each independently of one another denotes a hydrogen atom, alkyl, aryl or aralkyl, R8in each case independently denotes a straight or branched alkylenes, alkylidene or alkylidene chain, R17in each case independently denotes a hydrogen atom, alkyl, aryl, aralkyl, cyano, -OR5, -R8-OR5, -C(O)OR5, -R8-C(O)OR5, -C(O)-N(R5R6or-R8-C(O)-N(R5R6where R5and R6each independently of one another denotes a hydrogen atom, alkyl, aryl or aralkyl, and R8in each case independently denotes a straight or branched alkylenes, alkylidene or alkylidene chain.

27. Connection on p. 26, in which the N-heterocyclic ring substituted =N(R17and optionally substituted by one or more substituents selected from the group comprising alkyl, oxoprop, -C(O)OR5, -N(R5R6, -C(O)N(R5R6and -(R8-O)t-Rthe, R8in each case independently denotes a straight or branched alkylenes, alkylidene or alkylidene chain, R17in each case independently denotes a hydrogen atom, alkyl, aryl, aralkyl, cyano, -OR5, -R8-OR5, -C(O)OR5, -R8-C(O)OR5, -C(O)-N(R5R6or-R8-C(O)-N(R5R6where R5and R6each independently of one another denotes a hydrogen atom, alkyl, aryl or aralkyl, and R8in each case independently denotes a straight or branched alkylenes, alkylidene or alkylidene chain.

28. Connection on p. 27, which is selected from the group including

N-(5-chloropyridin-2-yl)-2-{{[4-[(2-imino-5-methyltetrahydrofolate-3-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(2-imino-5,5-(dimethyl)tetrahydrooxazolo-3-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(2-ethylimino-5,5-(dimethyl)tetrahydrooxazolo-3-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(2-imino-5(S)-methyltetrahydrofolate-3-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(2-them is iridin-2-yl)-2-{{[4-[(2-aminotetrahydrofuran-3-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(2-imino-5-(methoxymethyl)tetrahydrooxazolo-3-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(2-imino-4-methyltetrahydrofolate-3-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(TRANS-4,5-dimethyl-2-aminotetrahydrofuran-3-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(CIS-4,5-dimethyl-2-aminotetrahydrofuran-3-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(3-methyl-2-imino-2,3-dihydroimidazole-1-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(2-aminotetrahydrofuran-1-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(2-imino-1,2-dihydropyrimidin-1-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(2-imino-4-(hydroxymethyl)tetrahydrooxazolo-3-yl)methyl]-3-chlorothiophene-2-yl]carbonyl]amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(2-aminotetrahydrofuran-3-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(h-2-yl)-2-{{[4-[(tetrahydro-2-imino-2H-pyrimidine-1-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(2-(methoxycarbonylamino)imidazolin-1-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(2-(cyanoimino)tetrahydroimidazo-1-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(2-imino-3-((phenylamino)carbonyl)tetrahydroimidazo-1-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(CIS-4,5-dimethoxy-2-aminotetrahydrofuran-1-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(2-amino-4-imino-1,4-dihydropyrimidin-1-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(2-((2-hydroxyethyl)imino)tetrahydroimidazo-1-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-aloperidin-2-yl)-2-{{[4-[(2-aminopiperidin-1-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(4-imino-1(4H)-pyridinyl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(2-imino-1(2H)-pyridine-1-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(2-(ethylimino)perinatalogy)methyl)imino)tetrahydroimidazo-1-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide.

29. Connection on p. 21, in which the N-heterocyclic ring is substituted by-N(R5R6and optionally substituted by one or more substituents selected from the group comprising alkyl, oxoprop, -N(R5R6, -OR5and-C(O)N(R5R6where R5and R6each independently of one another denotes a hydrogen atom, alkyl, aryl or aralkyl.

30. Connection on p. 29, which is selected from the group including

N-(5-chloropyridin-2-yl)-2-{{[4-[(2-aminoimidazo-1-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(5-aminotetrazole-1-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(3-amino-1,2,4-triazole-1-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-Li)-2-{{[4-[(3,5-diamino-4H-l,2,4-triazole-4-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(4-amino-5-aminocarbonyl)imidazol-1-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(2,6-diaminopurine-9-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(2,6-diaminopurine-7-yl)methyl]-3-chlorothiophene-2-yl]carb is the dryer-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(6-aminopurin-9-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(6-aminopurin-7-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino]-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(2-amino-6-oxoborn-9-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(2-amino-6-oxoborn-7-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(5-(dimethylamino)-1,2,4-oxadiazol-3-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(5-amino-1,2,4-oxadiazol-3-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(2-(methylamino)imidazol-1-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(2,4-diamino-6-hydroxypyrimidine-5-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(2-(ethylamino)imidazol-1-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-harperteen-2-yl)-2-{{[4-[(2-(1-methylethyl)imidazol-1-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(3-iridin-2-yl)-2-{{[4-[(3-dimethylamino-5-methylpyrazole-2-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide.

31. Connection on p. 10, in which R14in each case independently denotes an alkyl, R8-CN, -C(R7)H-R8-N(R10R11, -C(R7)H-R8-N(R9)(R16)2, -C(R7)H-OR5, -C(R7)H-R8-OR5, -C(R7)H-O-R15, -C(R7)H-S(O)p-R15(where R=0-2), -C(R7)H-N(R5)-(R8-O)t-R5(where t=1 to 6), -C(R7)H-N(R5)-R8-[CH(OH)]t-CH2-OR5(where t=1 to 6), -C(R7)H-N(R5)-S(O)2-N(R10R11, -C(R7)H-O-N(R5R6or heterocyclyl [where heterocyclyl radical is not associated with the radical of the formula (i) via a nitrogen atom and optionally substituted by alkyl, aryl, aralkyl, halo, haloalkyl, exography, -OR5, -C(O)OR5, -N(R5R6or-C(O)N(R5R6], where R5and R6each independently of one another denotes a hydrogen atom, alkyl, aryl or aralkyl, R7in each case independently denotes a hydrogen atom or alkyl, R8in each case independently denotes a straight or branched alkylenes, alkylidene or alkylidene chain, R10and R11each independently of one another denotes a hydrogen atom, alkyl, haloalkyl, aryl, aralkyl,b>-R15(where R=0-2), -N(R5R6, -R8-N(R5R6, -R8-C(O)OR5, -C(O)-R15-C(O)NH2, -R8-C(O)NH2, -C(S)NH2, -C(O)-SR5, -C(O)-N(R5R15, -R8-C(O)N(R5R15, -C(S)-N(R5R15, -R8-N(R5)-C(O)H, -R8-N(R5)-C(O)R15-C(O)O-R8-N(R5R6:- C[N(R5R6]=C(R18R10, -R8-N(R5)-P(O)(OR5)2cycloalkyl (optionally substituted by one or more substituents selected from the group comprising alkyl, halo and-OR5), heterocyclyl [optionally substituted by alkyl, aryl, aralkyl, halo, haloalkyl, exography, -OR5, -R8-OR5-C(O)OR5, -S(O)p-R9(where R=0-2), -R8-S(O)p-R9(where R=0-2), -N(R5R6or-C(O)N(R5R6] or geterotsiklicheskikh [optionally substituted by one or more substituents selected from the group comprising alkyl, aryl, aralkyl, halo, haloalkyl, oxoprop, -OR5, -R8-OR5, -C(O)OR5, -S(O)p-R9(where R=0-2), -R8-S(O)p-R9(where R=0-2), -N(R5R6and-C(O)N(R5R6], where R5and R6each independently of one another denotes a hydrogen atom, alkylidene or alkylidene chain, R9in each case independently denotes an alkyl, aryl or aralkyl, R15in each case independently denotes an alkyl, cycloalkyl, haloalkyl, aryl, aralkyl, -R8-O-C(O)-R5, -R8-OR5, -N(R5R6, -R8-N(R5R6, -R8-C(O)OR5, heterocyclyl [optionally substituted by one or more substituents selected from the group comprising alkyl, aryl, aralkyl, halo, haloalkyl, -OR5, -R8-OR5, -C(O)OR5, -N(R5R6and-C(O)N(R5R6] or geterotsiklicheskikh [optionally substituted by one or more substituents selected from the group comprising alkyl, aryl, aralkyl, halo, haloalkyl, -OR5, -R8-OR5, -C(O)OR5, -N(R5R6and-C(O)N(R5R6], where R5and R6each independently of one another denotes a hydrogen atom, alkyl, aryl or aralkyl, and R8in each case independently denotes a straight or branched alkylenes, alkylidene or alkylidene chain, or R5and R15together with the nitrogen atom to which they are attached, form a N-heterocyclic ring containing zero to two additional heteroatoms, where N-heterocyclic ring optionally, samadiyami-, dialkylamino, -OR5, -C(O)OR5aminocarbonyl, monoalkylamines and dialkylaminoalkyl, where R5in each case denotes hydrogen atom, alkyl, aryl or aralkyl, and R18denotes a hydrogen atom, alkyl, aryl, aralkyl, cyano, -C(O)OR5or NO2or R10and R11together with the nitrogen atom to which they are attached, form a N-heterocyclic ring containing zero to two additional heteroatoms, where N-heterocyclic ring optionally substituted by one or more substituents selected from the group comprising alkyl, halo, haloalkyl, aryl, aralkyl, oxo, nitro, cyano, -R8-CN, =N(R17), -OR5, -C(O)OR5, -R8-C(O)OR5, -N(R5R6, -R8-N(R5R6-C(O)N(R5R6, -R8-C(O)N(R5R6, -N(R5)-N(R5R6, -C(O)R5-C(O)-(R8-O)t-R5(where t=1 to 6), -S(O)p-R9(where R=0-2), -R8-S(O)pR9- (where R=0-2), -(R8-O)t-R5(where t=1-6) and heterocyclyl [optionally substituted by one or more substituents selected from the group comprising alkyl, aryl, aralkyl, halo, haloalkyl, -OR5, -C(O)OR5, -N(R5R6and-C(O)N(R5)R, R8in each case independently denotes a straight or branched alkylenes, alkylidene or alkylidene chain, R9in each case independently denotes an alkyl, aryl or aralkyl, R17in each case independently denotes a hydrogen atom, alkyl, aryl, aralkyl, cyano, -OR5, -R8-OR5, -C(O)OR5, -R8-C(O)OR5-C(O)-N(R5R6or-R8-C(O)-N(R5R6where R5and R6each independently of one another denotes a hydrogen atom, alkyl, aryl or aralkyl, and R8in each case independently denotes a straight or branched alkylenes, alkylidene or alkylidene chain, R16in each case independently denotes an alkyl, aryl, aralkyl, -R8-O-R5, -R8-N(R5R6cycloalkyl (optionally substituted by one or more substituents selected from the group comprising alkyl, halo and-OR5), heterocyclyl [optionally substituted by alkyl, aryl, aralkyl, halo, haloalkyl, -OR5-C(O)or SIG5, -N(R5R6or-C(O)N(R5R6] or geterotsiklicheskikh [optionally substituted by one or more substituents selected from the group comprising alkyl, aryl, aralkyl, halo is independently from each other represents a hydrogen atom, alkyl, aryl or aralkyl, and R8in each case independently denotes a straight or branched alkylenes, alkylidene or alkylidene chain, or both R16together with the nitrogen atom to which they relate (and when there is no substituent R9form an aromatic N-heterocyclic ring containing zero to two additional heteroatoms, where N-heterocyclic ring optionally substituted by one or more substituents selected from the group comprising alkyl, aryl, aralkyl, -OR5, -R8-OR5, -C(O)OR5, -R8-C(O)OR5, -N(R5R6, -R8-N(R5R6, -C(O)R5, -C(O)-(R8-O)t-R5(where t=1-6) and -(R8-O)t-R5(where t=1-6), where R5and R6each independently of one another denotes a hydrogen atom, alkyl, aryl or aralkyl, and R8in each case independently denotes a straight or branched alkylenes, alkylidene or alkylidene chain.

32. Connection on p. 31, which is selected from the group including

N-(5-chloropyridin-2-yl)-2-{{[4-[(pyridine-1-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino]-3-hydroxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(N'-methyl-N'-(2-(hydroxyethoxy)ethyl)amino)methyl]-3-chlorite-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(N'-methyl-N'-(2,3-dihydroxypropyl)amino)methyl]-3-chlorothiophene-2-yl]carbonyl]amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(2-hydroxyethyl)sulfinil)methyl]-3-chlorothiophene-2-yl]carbonyl}amino]-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(pyridine-1-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-methyl-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-cyanomethyl-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-(2-methylaminomethyl)-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-(hydroxy)methyl-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-(((imidazol-2-yl)thio)methyl)-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-((imidazolin-2-yl)thio)methyl)-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-(((5-hydroxymethyl-1-Mei-2-yl)thio)methyl)-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-(((diethylamino)oxy)methyl)-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorbenzol 33. Connection on p. 10, in which R14in each case independently represents-C(R7)H-N(R10)-, -C(NR17)-N(R10R11, -C(R7)H-N(R10)-C(NR17)-R10or-C(R7)H-C(NR17)-N(R5R6where R5and R6in each case independently denotes a hydrogen atom, alkyl, aryl or aralkyl, R7in each case independently denotes a hydrogen atom or alkyl, R9in each case independently denotes an alkyl, aryl or aralkyl, R10and R11each independently of one another denotes a hydrogen atom, alkyl, haloalkyl, aryl, aralkyl, formyl, cyano, -R8-CN, -OR5, -R8-OR5, -S(O)p-R15(where R=0-2), -R8-S(O)p-R15(where R=0-2), -N(R5R6, -R8-N(R5R6, -R8-C(O)OR5, -C(O)-R15, -C(O)NH2, -R8-C(O)NH2, -C(S)NH2, -C(O)-S-R5, -C(O)-N(R5R15, -R8-C(O)N(R5R15- (S)-N(R5R15, -R8-N(R5)-C(O)H, -R8-N(R5)-C(O)R15-C(O)O-R8-N(R5R6:- C[N(R5R6]=C(R18R10, -R8-N(R5)-P(O)(OR5)2cycloalkyl (optionally substituted by one or more substituents selected from the group, including what Kilom, exography, -OR5, -R8-OR5, -C(O)OR5, -S(O)p-R9(where R=0-2), -R8-S(O)p-R9(where R=0-2), -N(R5R6or-C(O)N(R5R6] or geterotsiklicheskikh [optionally substituted by one or more substituents selected from the group comprising alkyl, aryl, aralkyl, halo, haloalkyl, oxoprop, -OR5, -R8-OR5, -C(O)OR5, -S(O)p-R9(where R=0-2), -R8-S(O)p-R9(where R=0-2), -N(R5R6and-C(O)N(R5R6], where R5and R6each independently of one another denotes a hydrogen atom, alkyl, aryl or aralkyl, R8in each case independently denotes a straight or branched alkylenes, alkylidene or alkylidene chain, R9in each case independently denotes an alkyl, aryl or aralkyl, R15in each case independently denotes an alkyl, cycloalkyl, haloalkyl, aryl, aralkyl, -R8-O-C(O)-R5, -R8-OR5, -N(R5R6, -R8-N(R5R6, -R8-C(O)OR5, heterocyclyl [optionally substituted by one or more substituents selected from the group comprising alkyl, aryl, aralkyl, halo, haloalkyl, -OR5, -R8-OR5, -C(O)OR5, -N(R5R65, -R8-OR5, -C(O)OR5, -N(R5R6and-C(O)N(R5R6], where R5and R6each independently of one another denotes a hydrogen atom, alkyl, aryl or aralkyl, and R8in each case independently denotes a straight or branched alkylenes, alkylidene or alkylidene chain, or R5and R15together with the nitrogen atom to which they are attached, form a N-heterocyclic ring containing zero to two additional heteroatoms, where N-heterocyclic ring optionally substituted by one or more substituents selected from the group comprising alkyl, aryl, aralkyl, amino, monoalkylamines, dialkylamines, -OR5, -C(O)OR5aminocarbonyl, monoalkylamines and dialkylaminoalkyl, where R5in each case denotes hydrogen atom, alkyl, aryl or aralkyl, and R18denotes a hydrogen atom, alkyl, aryl, aralkyl, panograph, -C(O)OR5or NO2or R10and R11together with the nitrogen atom to which they are attached, form a N-heterocyclic ring containing zero to two additional heteroatoms, where N-heterocyclic Ko is about, haloalkyl, aryl, aralkyl, oxo, nitro, cyano, -R8-CN, =N(R17), -OR5, -C(O)OR5, -R8-C(O)OR5, -N(R5R6, -R8-N(R5R6-C(O)N(R5R6, -R8-C(O)N(R5R6, -N(R5)-N(R5R6-C(O)R5-C(O)-(R8-O)t-R5(where t=1 to 6), -S(O)p-R9(where R=0-2), -R8-S(O)p-R9(where R=0-2), -(R8-O)t-R5(where t=1-6) and heterocyclyl [optionally substituted by one or more substituents selected from the group comprising alkyl, aryl, aralkyl, halo, haloalkyl, -OR5, -C(O)OR5, -N(R5R6and-C(O)-N(R5R6], where R5and R6each independently of one another denotes a hydrogen atom, alkyl, aryl or aralkyl, R8in each case independently denotes a straight or branched alkylenes, alkylidene or alkylidene chain, R9in each case independently denotes an alkyl, aryl or aralkyl, R17in each case independently denotes a hydrogen atom, alkyl, aryl, aralkyl, cyano, -OR5, -R8-OR5, -C(O)OR5, -R8-C(O)-OR5, -C(O)-N(R5R6or-R8-C(O)-N(R5R6where R5and R6each independently from each other habasitlink alkylenes, alkylidene or alkylidene chain, R17in each case independently denotes a hydrogen atom, alkyl, aryl, aralkyl, cyano, -OR5, -R8-OR5, -C(O)OR5, -R8-C(O)OR5, -C(O)-N(R5R6or-R8-C(O)-N(R5R6where R5and R6each independently of one another denotes a hydrogen atom, alkyl, aryl or aralkyl, and R8in each case independently denotes a straight or branched alkylenes, alkylidene or alkylidene chain.

34. Connection on p. 33, which is selected from the group including

N-(5-chloropyridin-2-yl)-2-{{[4-[((amidino)(methyl)amino)methyl]-3-chlorothiophene-2-yl]carbonyl]amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(N'-(1-iminoethyl)-N'-methylamino)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[N N-dimethyl-N'"-cyanoguanidine)methyl]-3-chlorothiophene-2-yl]carbonyl}amino]-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[N'-methyl-N"-hydroxyguanidine)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[N'-methyl-N-(2-amino-ethyl)-N'"-cyanoguanidine)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[N'-methyl-N"-Minogue-N'"-(aminocarbonyl)guanidino)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(N'-(imino(phenyl)methyl)amino)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(N'-(1-imino-2-(aminocarbonyl)ethyl)amino)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(N'-(1-imino-4,4,4-triptorelin(amino)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(N'-(imino(pyridin-4-yl)amino)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(N'-(imino(thiophene-2-yl)methyl)amino)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(N'-(imino(pyrazin-2-yl)methyl)amino)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{[[4-[(N'-(cyclopropyl(imino)methyl)amino)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(N'-ethyl-N'-(3-cyano-1-aminopropyl)amino)methyl]-3-chlorothiophene-2-yl]carbonyl}amino]-3-methoxy-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(N'-methyl-N'-(1-imino-4,4,4-trifloromethyl)amino)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide and

N-(5-chloropyridin-2-yl)-2-{{[4-[2-amino-2-(hydroxyimino)ethyl]-3-chlorothiophene-2-yl]carb)-, E represents-C(O)-N(H)- (where the nitrogen atom is attached to pyridinoline ring in the 2nd position), R2represents-N(R10R11where R10and R11each independently of one another denotes a hydrogen atom, alkyl or-R8-O-R5where R8means alkylenes chain, and R5denotes a hydrogen atom or alkyl, or R10and R11together with the nitrogen atom to which they are attached, form a N-heterocyclic ring containing zero to three additional heteroatoms, where N-heterocyclic ring optionally substituted by one or more substituents selected from the group comprising alkyl and-C(O)OR5where R5denotes a hydrogen atom or alkyl, R3denotes a radical of the formula (i)

where r=1;

R13represents halo; and

R14denotes-C(R7)H-N(R10R11or-C(R7)N-N(R5)-R8-[CH(OH)]t-CH2-OR5(where t=1-3), where R5in each case independently denotes a hydrogen atom or alkyl, R7denotes a hydrogen atom, R8denotes a straight or branched alkylenes chain, R10and R11each independently of one another denotes a hydrogen atom, alkyl, the15, -C(O)NH2, -C(S)NH2, -C(O)-N(R5R15, -C(S)-N(R5Rl5cycloalkyl (optional substituted-OR5), heterocyclyl [optionally substituted by one or more substituents selected from the group comprising alkyl, haloalkyl, oxoprop, -OR5and-C(O)OR5] or geterotsiklicheskikh [optionally substituted by one or more substituents selected from the group comprising alkyl, haloalkyl, oxoprop, -OR5and-C(O)OR5], where R5and R6in each case independently denotes a hydrogen atom or alkyl, R8in each case independently denotes a straight or branched alkylenes chain, and R15in each case denotes alkyl, -R8-OR5, -R8-C(O)OR5, heterocyclyl (optionally substituted by-R8-OR5or geterotsiklicheskikh (optional substituted-OR5), or R10and R11together with the nitrogen atom to which they are attached, form a N-heterocyclic ring containing zero to two additional heteroatoms, where N-heterocyclic ring optionally substituted by one or more substituents selected from the group comprising alkyl, oxoprop, =N(R17), -OR5, -R8-OR5Il, R8denotes a straight or branched alkylenes chain, and R17in each case independently denotes a hydrogen atom, alkyl, aryl, aralkyl, cyano, -OR5, -R8-OR5-C(O)OR5, -R8-C(O)OR5-C(O)N(R5R6or-R8-C(O)N(R5R6and R4is in the 5th position and represents a hydrogen atom or a halo.

36. Connection on p. 35, in which R2represents-N(R10R11where R10and R11each independently of one another denotes a hydrogen atom, alkyl or-R8-O-R5where R8means alkylenes chain, and R5denotes a hydrogen atom or alkyl.

37. Connection on p. 36, in which R14denotes-C(R7)N-N(R10R11where R7denotes a hydrogen atom, R10and R11each independently of one another denotes a hydrogen atom, alkyl, formyl, -R8-OR5, -S(O)p-R15(where R=0-2), -R8-N(R5R6, -R8-C(O)OR5, -C(O)-R15, -C(O)NH2, -C(S)NH2, -C(O)-N(R5R15, -C(S)-N(R5R15cycloalkyl (optional substituted-OR5), heterocyclyl [optionally substituted by one or more substituents selected from the group comprising Alki more substituents, selected from the group comprising alkyl, haloalkyl, oxoprop, -OR5and-C(O)OR5], where R5and R6each denotes a hydrogen atom or alkyl, R8in each case independently denotes a straight or branched alkylenes chain, and R15in each case denotes alkyl, -R8-OR5, -R8-C(O)OR5, heterocyclyl (optionally substituted by-R8-OR5or geterotsiklicheskikh (optional substituted-OR5), or R10and R11together with the nitrogen atom to which they are attached, form a N-heterocyclic ring containing zero to two additional heteroatoms, where N-heterocyclic ring optionally substituted by one or more substituents selected from the group comprising alkyl, oxoprop, =N(R17), -OR5, -R8-OR5and-N(R5R6where R5in each case denotes hydrogen atom or alkyl, R8denotes a straight or branched alkylenes chain, and R17in each case independently denotes a hydrogen atom, alkyl, aryl, aralkyl, cyano, -OR5, -R8-OR5, -C(O)OR5, -R8-C(O)OR5-C(O)N(R5R6or-R8-C(O)-N(R5R6.

38. Connection on p. 37, ivory chlorothiophene-2-yl]carbonyl}amino}-3-(dimethyl)amino-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(N'-methyl-N'-(2-(dimethylamino)ethyl)amino)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-(dimethyl)amino-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(N'-methyl-N'-(1-methylpiperidin-4-yl)amino)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-(dimethyl)amino-5-chlorobenzamide and

N-(5-chloropyridin-2-yl)-2-{{[4-[(N'-methyl-N'-(2-hydroxyethyl)amino)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-(di(2-methoxyethyl)amino)-5-chlorobenzamide.

39. Connection on p. 35, in which R2represents-N(R10R11where R10and R11together with the nitrogen atom to which they are attached, form a N-heterocyclic ring containing zero to two additional heteroatoms, where N-heterocyclic ring optionally substituted by one or more substituents selected from the group comprising alkyl and-C(O)OR5where R5denotes a hydrogen atom or alkyl.

40. Connection on p. 39, which is selected from the group including

N-(5-chloropyridin-2-yl)-2-{{[4-[(N'-methyl-N'-(2-(dimethylamino)ethyl)amino)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-(morpholine-4-yl)-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(N'-(2-hydroxyethyl)amino)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-(morpholine-4-yl)-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(N'-mate the DIN-2-yl)-2-{{[4-[(N'-methyl-N'-(1-methylpiperidin-4-yl)amino)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-(morpholine-4-yl)-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(N'-methyl-N'-(2-(morpholine-4-yl)ethyl)amino)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-(morpholine-4-yl)-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(N'-methyl-N'-(methylsulphonyl)amino)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-(morpholine-4-yl)-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(N'-methyl-N'-(3-(dimethylamino)propyl)amino)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-(morpholine-4-yl)-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(N'-methyl-N'-(2-(pyrrolidin-1-yl)ethyl)amino)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-(morpholine-4-yl)-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(N'-methyl-N'-(2-methoxyethyl)amino)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-(morpholine-4-yl)-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(N'-methylsulphonyl-N'-(2-(pyrrolidin-1-yl)ethyl)amino)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-(morpholine-4-yl)-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(N-methyl-N'-(2-(pyrrolidin-1-yl)ethyl)ureido)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-(morpholine-4-yl)-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(N'-methyl-N'-(methylsulphonyl)amino)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-(4-methylpiperazin-1-yl)-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(N'-methyl-N'-(2-hydroxyethyl)amino)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-(4-methylpiperazin-1-is}amino}-3-(pyrrolidin-1-yl)-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(N'-(1-methylethyl)-N'-(2-(pyrrolidin-1-yl)ethyl)amino)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-(morpholine-4-yl)-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(N'-methyl-N'-(2-hydroxyethyl)amino)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-(4-(etoxycarbonyl)piperidine-1-yl)-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(N'-methyl-N'-(2-hydroxyethyl)amino)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-(4-(carboxy)piperidine-1-yl)-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(N'-methyl-N'-(2,3-dihydroxypropyl)amino)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-(morpholine-4-yl)-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(N'-methyl-N"-ethylurea)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-(4-ethylpiperazin-1-yl)-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(N'-methyl-N'-(oxazoline-2-yl)amino)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-(morpholine-4-yl)-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(N'-ethyl-N'-(oxazoline-2-yl)amino)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-(morpholine-4-yl)-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(N'-methyl-N'-(4-trifluoromethyl-5-(methoxycarbonyl)pyrimidine-2-yl)amino)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-(morpholine-4-yl)-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(N'-methyl-N'-(4-trifluoromethyl-5-carboxyamide-2-yl)amino)methyl]-3-chlor-3-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-(morpholine-4-yl)-5-chlorobenzamide and

N-(5-chloropyridin-2-yl)-2-{{[4-[(N'-methyl-N'-(tetrazol-5-yl)amino)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-(morpholine-4-yl)-5-chlorobenzamide.

41. Connection on p. 1, And which represents =N-, m=1, n=1, D represents-N(H)-C(O)-, E represents-C(O)-N(H)- (where the nitrogen atom is attached to pyridinoline ring in the 2nd position), R2denotes-O-(R8-O)t-R5(where t denotes 1-3) or-O(R8O)t-R19where R5denotes a hydrogen atom or alkyl, R8in each case independently denotes a straight or branched alkylenes circuit, a R19means heterocyclyl (optionally substituted by alkyl, aryl, aralkyl, halo or haloalkyl),

R3denotes a radical of the formula (i)

where r=1;

R13represents halo; and

R14denotes-C(R7)N-N(R10R11where R7denotes a hydrogen atom, R10and R11each independently of one another denotes a hydrogen atom, alkyl, formyl, -R8-OR5, -S(O)p-R15(where R=0-2), -R8-N(R5R6, -R8-C(O)OR5, -C(O)-R15, -C(O)NH2, -C(S)NH2, -C(O)-N(R5R15, -C(S)-N(R5R15cycloalkyl (optional substituted-OR5), geterotsiklicheskikh, oxoprop, -OR5and-C(O)OR5] or geterotsiklicheskikh [optionally substituted by one or more substituents selected from the group comprising alkyl, haloalkyl, oxoprop, -OR5and-C(O)OR5], where R5and R6each denotes a hydrogen atom or alkyl, R8in each case independently denotes a straight or branched alkylenes chain, and R15in each case denotes alkyl, -R8-OR5, -R8-C(O)OR5, heterocyclyl (optionally substituted by-R8-OR5or geterotsiklicheskikh (optional substituted-OR5), or R10and R11together with the nitrogen atom to which they are attached, form a N-heterocyclic ring containing zero to two additional heteroatoms, where N-heterocyclic ring optionally substituted by one or more substituents selected from the group comprising alkyl, oxoprop, =N(R17), -OR5, -R8-OR5and-N(R5R6where R5in each case denotes hydrogen atom or alkyl, R8denotes a straight or branched alkylenes chain, and R17in each case independently denotes a hydrogen atom, alkyl, aryl, aralkyl, cyano, -OR5, -R8-OR5

42. Connection on p. 41, which is selected from the group including

N-(5-chloropyridin-2-yl)-2-{{[4-[(N'-methyl-N'-(2-(dimethylamino)ethyl)amino)methyl]-3-chlorothiophene-2-yl]carbonyl]amino}-3-(2-hydroxyethoxy)-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(N'-methyl-N'-(l-methylpiperidin-4-yl)amino)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-(2-hydroxyethoxy)-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(N'-methyl-N'-(2-(pyrrolidin-1-yl)ethyl)amino)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-(2-methoxyethoxy)-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(N'-methyl-N'-(2-(pyrrolidin-1-yl)ethyl)amino)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-(2-hydroxyethoxy)-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(N'-methyl-N'-(2,3-dihydroxypropyl)amino)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-(2-methoxyethoxy)-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(N'-ethyl-N'-(2-hydroxyethyl)amino)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-(2-methoxyethoxy)-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(N'-methyl-N'-(2-hydroxyethyl)amino)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-(2-methoxyethoxy)-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(N'-methyl-N'-(oxazoline-2-yl)amino)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-(2-(2-methoxyethoxy)ethoxy)-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(N'-methyl-N'-(matilal the Jn-2-yl)-2-{{[4-[(N'-methyl-N'-(2-hydroxyethyl)amino)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-(3-(pyridine-3-yloxy)propoxy)-5-chlorobenzamide.

43. Connection on p. 1, And which represents =N-, m=1, n=1, D represents-N(H)-C(O)-, E represents-C(O)-N(H)- (where the nitrogen atom is attached to pyridinoline ring in the 2nd position), R2denotes-O-R8-N(R10R11where R8denotes a straight or branched alkylenes chain, and R10and R11each independently of one another denotes a hydrogen atom, alkyl or-R8-O-R5where R8means alkylenes chain, and R5denotes a hydrogen atom or alkyl, or R10and R11together with the nitrogen atom to which they are attached, form a N-heterocyclic ring containing zero to two additional heteroatoms, where N-heterocyclic ring optionally substituted by one or more substituents selected from the group comprising alkyl and-C(O)OR5where R5denotes a hydrogen atom or alkyl, R3denotes a radical of the formula (i)

where r=1;

R13represents halo; and

R14denotes-C(R7)H-N(R10R11where R7denotes a hydrogen atom, R10and R11each independently of one another denotes a hydrogen atom, alkyl, formyl, -R8-OR5, -S(O)p-R15(where R=0-2), -R8<(R5R15cycloalkyl (optional substituted-OR5), heterocyclyl [optionally substituted by one or more substituents selected from the group comprising alkyl, haloalkyl, oxoprop, -OR5and-C(O)OR5] or geterotsiklicheskikh [optionally substituted by one or more substituents selected from the group comprising alkyl, haloalkyl, oxoprop, -OR5and-C(O)OR5], where R5and R6each denotes a hydrogen atom or alkyl, R8in each case independently denotes a straight or branched alkylenes chain, and R15in each case denotes alkyl, -R8-OR5, -R8-C(O)OR5, heterocyclyl (optionally substituted by-R8-OR5or geterotsiklicheskikh (optional substituted-OR5and R4is in the 5th position and represents a hydrogen atom or a halo.

44. Connection on p. 43, which is selected from the group including

N-(5-chloropyridin-2-yl)-2-{{[4-[(N'-methyl-N'-(1-methylpiperidin-4-yl)amino)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-(3-(morpholine-4-yl)propoxy)-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(N'-methyl-N'-(2-hydroxyethyl)amino)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-(3-(pyrrolidin-1-yl)propoxy)-5-chlorobenzamide,

N-(5-chlorine is ISQ)-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(N'-methyl-N'-(2-hydroxyethyl)amino)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-(2-(imidazol-1-yl)ethoxy)-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(N'-methyl-N'-(2-hydroxyethyl)amino)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-(3-(imidazol-1-yl)propoxy)-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(N'-methyl-N'-(methylsulphonyl)amino)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-(2-(pyrrolidin-1-yl)ethoxy)-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(N'-methyl-N'-(methylsulphonyl)amino)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-(2-(imidazol-1-yl)ethoxy)-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(N'-methyl-N'-(2-hydroxyethyl)amino)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-(2-(pyrrolidin-1-yl)ethoxy)-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(N'-methyl-N'-(methylsulphonyl)amino)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-(3-(4-ethylpiperazin-1-yl)propoxy)-5-chlorobenzamide and

N-(5-chloropyridin-2-yl)-2-{{[4-[(N'-methyl-N'-(methylsulphonyl)amino)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-(2-aminoethoxy)-5-chlorobenzamide.

45. Connection on p. 1, And which represents =N-, m=1, n=1, D represents-N(H)-C(O)-, E represents-C(O)-N(H)- (where the nitrogen atom is attached to pyridinoline ring 2nd position), R2denotes-O-R8-O-C(O)R5, -O-R8-CH(OH)-CH2- the Yes or alkyl, R8denotes a straight or branched alkylenes chain, and R10and R11each independently of one another denotes a hydrogen atom, alkyl or-R8-O-R5where R8means alkylenes chain, and R5denotes a hydrogen atom or alkyl, or R10and R11together with the nitrogen atom to which they are attached, form a N-heterocyclic ring containing zero to two additional heteroatoms, where N-heterocyclic ring optionally substituted by one or more substituents selected from the group comprising alkyl and-C(O)OR5where R5denotes a hydrogen atom or alkyl, R3denotes a radical of the formula (i)

where r=1;

R13represents halo; and

R14denotes-C(R7)N-N(R10R11or-C(R7)N-N(R5)-S(O)2-N(R10R11where R5denotes a hydrogen atom or alkyl, R7denotes a hydrogen atom, R10and R11each independently of one another denotes a hydrogen atom, alkyl, formyl, -R8-OR5, -S(O)p-R15(where R=0-2), -R8-N(R5R6, -R8-C(O)OR5, -C(O)-R15, -C(O)NH2, -C(S)NH2, -C(O)-N(R5R15, -C(S)-N(R5 is more substituents, selected from the group comprising alkyl, haloalkyl, oxoprop, -OR5and-C(O)OR5] or geterotsiklicheskikh [optionally substituted by one or more substituents selected from the group comprising alkyl, haloalkyl, exography, -OR5and-C(O)OR5], where R5and R6each denotes a hydrogen atom or alkyl, R8in each case independently denotes a straight or branched alkylenes chain, and R15in each case denotes alkyl, -R8-OR5, -R8-C(O)OR5, heterocyclyl (optionally substituted by-R8-OR5or geterotsiklicheskikh (optional substituted-OR5and R4is in the 5th position and represents a hydrogen atom or a halo.

46. Connection on p. 45, which is selected from the group including

N-(5-chloropyridin-2-yl)-2-{{[4-[(N'-methyl-N'-(2-(pyrrolidin-1-yl)ethyl)amino)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-(2-acetoacetate)-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(N'-methyl-N'-(methylsulphonyl)amino)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-(2-hydroxy-3-(pyrrolidin-1-yl)propoxy)-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-[(N'-methyl-N'-(dimethylamino)sulfonyl)amino)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-(2-hydroxy-3-(pyrrolidin-1-yl)propoxy)-5-HNO}-3-(2-hydroxy-3-(imidazol-1-yl)propoxy)-5-chlorobenzamide and

N-(5-chloropyridin-2-yl)-2-{{[4-[(N'-methyl-N'-(methylsulphonyl)amino)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-(2-hydroxy-3-methoxy-propoxy)-5-chlorobenzamide.

47. Connection on p. 1, And which represents =N-, m=1-3, n=1, D represents-N(R5)-C(Z) (where Z denotes an oxygen atom, a R5denotes a hydrogen atom or alkyl), E denotes-C(Z)-N(R5)- (where Z denotes an oxygen atom, R5denotes a hydrogen atom or alkyl, and the nitrogen atom is linked to pyridinium ring), R1in each case independently denotes a hydrogen atom, halo, or hydroxy, R2denotes a hydrogen atom, R3denotes a radical of the formula (i)

where r=1;

R13represents halo; and

R14denotes-C(R7)H-N(R10R11where R7denotes a hydrogen atom, and R10and R11each independently of one another denotes a hydrogen atom, alkyl, formyl, -R8-OR5, -S(O)-R15(where R=0-2), -R8-N(R5R6, -R8-C(O)OR5, -C(O)-R15, -C(O)NH2, -C(S)NH2-C(O)N(R5R15, -C(S)-N(R5R15cycloalkyl (optional substituted-OR5), heterocyclyl [optionally substituted by one or more substituents selected from the groups is shifted by one or more substituents, selected from the group comprising alkyl, haloalkyl, oxoprop, -OR5and-C(O)OR5], where R5and R6each denotes a hydrogen atom or alkyl, R8in each case independently denotes a straight or branched alkylenes chain, and R15in each case denotes alkyl, -R8-OR5, -R8-C(O)OR5, heterocyclyl (optionally substituted by-R8-OR5or geterotsiklicheskikh (optional substituted-OR5and R4is in the 5th position and represents a hydrogen atom or a halo.

48. Connection on p. 47, which is selected from the group including

N-(5-chloropyridin-2-yl)-2-{{[4-[(N'-methyl-N'-(2-hydroxyethyl)amino)methyl]-3-chlorothiophene-2-yl]carbonyl}amino]-3,4,5-trimethoxybenzamide,

5-[N-(5-chloropyridin-2-yl)amino]carbonyl-6-{4-[(N'-methyl-N'-(oxazoline-2-yl)amino)methyl]-3-chlorothiophene-2-yl]carbonyl]amino}-1,3-benzodioxol,

5-[N-(5-chloropyridin-2-yl)amino]carbonyl-6-{4-[(N'-methyl-N'-(2-hydroxyethyl)amino)methyl]-3-chlorothiophene-2-yl]carbonyl]amino}-1,3-benzodioxol and

5-[N-(5-chloropyridin-2-yl)amino]carbonyl-6-{4-[(N'-(2-methoxyethyl)-N'-(oxazoline-2-yl)amino)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-1,3-benzodioxol.

49. Connection on p. 1, And which represents =CH-, m=1, n=1, D represents-N(R5)-C(Z) (where Z hereafter the d ring, containing R1and R2deputies), E denotes-C(Z)-N(R5)- (where Z denotes an oxygen atom, R5denotes a hydrogen atom or alkyl, and the nitrogen atom is linked to the phenyl ring containing substituent R4), R1represents halo, R2denotes a hydrogen atom, alkyl, aryl, aralkyl, halo, haloalkyl, cyano, -OR5, -S(O)p-R9(where R=0-2), -C(O)OR5, -C(O)N(R5R6, -N(R10R11, -C(R7)H-OR5, -C(R7)H-S(O)p-R9(where R=0-2), -O-R8-S(O)p-R9(where R=0-2), -C(R7)H-N(R5R6, -O-R8-CH(OH)-CH2-N(R10R11, -O-R8-N(R10R11, -O-R8-O-C(O)R5, -O-R8-CH(OH)CH2-OR5, -O-(R8O)t-R5(where t=1 to 6), -O-R8-C(O)R5, -O-R8-C(O)R5, -N(R5)-R8-N(R10R11, -S(O)p-R8-N(R5R6(where R=0-2), -S(O)p-R8-C(O)OR5(where R=0-2), or-N(R5)-CH(R12)-C(O)OR5, R3denotes a radical of the formula (i)

where r=1;

R13denotes a hydrogen atom, alkyl, halo, haloalkyl; and

R14in each case independently denotes a hydrogen atom, alkyl, halo, formyl, acetyl, -N(R10R11, R8-C(O)OR5, -C(R7)H-N(R5)-R8-C(O)OR5, -C(O)OR5, -OR5, -C(R7)H-OR5, -S(O)p-R15(where R=0-2), -C(R7)H-S(O)p-R15(where R=0-2), -S(O)p-N(R5R6(where R=0-2), -C(O)N(R5R6, -C(R7)H-N(R5)-(R8-O)t-R5(where t=1 to 6), -O-R8-CH(OH)-CH2-Or SIG5, -C(R7)H-O-R8-CH(OH)-CH2-OR5-C(R7)N-N(R5)-R8-[CH(OH)]t-CH2-Or SIG5(where t=1 to 6), -C(R7)H-N(R5)-S(O)2-N(R10R11, -C(R7)H-N(R10)-C(NR17)- N(R10R11or-C(R7)H-N(R10)-C(NR17)-R10, R4represents halo, R5and R6each independently of one another denotes a hydrogen atom, alkyl, aryl or aralkyl, R7denotes a hydrogen atom or alkyl, R8in each case independently denotes a straight or branched alkylenes or alkylidene chain, R9in each case independently denotes an alkyl, ariell and aralkyl, R10and R11each independently of one another denotes a hydrogen atom, alkyl, aryl, aralkyl, formyl, -OR5, -R8-OR5, -S(O)p-R15(where R=0-2), -R8-N(R5R6, -R8-C(O)OR5, -C(O)R15, -C(O)NH2-C(S)NHmi substituents, selected from the group comprising alkyl, halo and-OR5), heterocyclyl [optionally substituted by alkyl, aryl, aralkyl, halo, haloalkyl, exography, -OR5, -C(O)OR5, -N(R5R6or-C(O)N(R5R6] or geterotsiklicheskikh [optionally substituted by one or more substituents selected from the group comprising alkyl, aryl, aralkyl, halo, haloalkyl, oxoprop, -OR5, -C(O)OR5, -N(R5R6and-C(O)N(R5R6] or R10and R11together with the nitrogen atom to which they are attached, form a N-heterocyclic ring containing zero to two additional heteroatoms, where N-heterocyclic ring optionally substituted by one or more substituents selected from the group comprising alkyl, aryl, aralkyl, oxoprop and =N(R7), -OR5, -C(O)OR5, -R8-C(O)OR5, -N(R5R6, -R8-N(R5R6, -C(O)R5-C(O)-(R8-O)t-R5(where t=1-6) and -(R8-O)t-R5(where t=1-6), R12denotes the side chain of-amino acids, R15in each case independently denotes an alkyl, haloalkyl, aryl, aralkyl, -R8-OR5, -R8-N(R5R6, -R8-C(O)OR5she alkyl, aryl, aralkyl, halo, haloalkyl, -OR5-C(O)or SIG5, -N(R5R6and-C(O)N(R5R6] or geterotsiklicheskikh [optionally substituted by one or more substituents selected from the group comprising alkyl, aryl, aralkyl, halo, haloalkyl, -OR5, -C(O)OR5, -N(R5R6and-C(O)N(R5R6], or R5and R15together with the nitrogen atom to which they are attached, form a N-heterocyclic ring containing zero to two additional heteroatoms, where N-heterocyclic ring optionally substituted by one or more substituents selected from the group comprising alkyl, aryl, aralkyl, amino, monoalkylamines, dialkylamines, -OR5, -C(O)OR5aminocarbonyl, monoalkylamines and dialkylaminoalkyl, and R16in each case independently denotes an alkyl, aryl, aralkyl, -R8-OR5, -R8-N(R5R6cycloalkyl (optionally substituted by one or more substituents selected from the group comprising alkyl, halo and-OR5), heterocyclyl [optionally substituted by alkyl, aryl, aralkyl, halo, haloalkyl, -OR5, -C(O)OR5, -N(R5R6or-C(O)N(R5R6] or geterotsiklicheskikh [neomail, halo, haloalkyl, -OR5, -C(O)OR5, -N(R5R6and-C(O)N(R5R6], or both R16together with the nitrogen atom to which they relate (and when there is no substituent R9form an aromatic N-heterocyclic ring containing zero to two additional heteroatoms, where N-heterocyclic ring optionally substituted by one or more substituents selected from the group comprising alkyl, aryl, aralkyl, -OR5, -C(O)OR5, -R8-C(O)OR5, -N(R5R6, -R8-N(R5R6-C(O)R5-C(O)-(R8-O)t-R5(where t=1-6) and -(R8-O)t-R5(where t=1-6).

50. Connection on p. 49, in which D represents-N(H)-C(O)-, E represents-C(O)-N(H)-, R1represents halo, R2denotes a hydrogen atom, -OR5, -N(R10R10, -O-R8-S(O)p-R9(where R=0-2), -O-R8-N(R10R11, -O-R8-O-C(O)OR5or-O-R8-C(O)or SIG5where R5in each case denotes hydrogen atom or alkyl, R8in each case independently denotes a straight or branched alkylenes chain, R9denotes alkyl, R10and R11together with the nitrogen atom to which they are attached, form an N-heterocyclic src="https://img.russianpatents.com/img_data/76/760230.gif">

where r=1;

R13represents halo; and

R14is in the 4th position and represents-C(R7)H-N(R10R11where R7denotes a hydrogen atom or alkyl, and R10and R11each independently of one another denotes a hydrogen atom, alkyl-R8-OR5or heterocyclyl or R10and R11together with the nitrogen atom to which they are bound, form a pieperazinove ring, optionally substituted alkyl, and R4denotes a chlorine atom.

51. Connection on p. 50, which is selected from the group including

N-(4-chlorophenyl)-2-{{[4-[(4-methylpiperazin-1-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(4-chlorophenyl)-2-{{[4-[(4-methylpiperazin-1-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-hydroxy-5-chlorobenzamide,

N-(4-chlorophenyl)-2-{{[4-[(4-methylpiperazin-1-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-5-perbenzoic,

N-(4-chlorophenyl)-2-{{[4-[(4-methylpiperazin-1-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-(etoxycarbonyl)methoxy-5-chlorobenzamide,

N-(4-chlorophenyl)-2-{{[4-[(4-methylpiperazin-1-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-((acetoxy)ethoxy)-5-chlorobenzamide,

N-(4-chlorophenyl)-2-{{[4-[(4-methylpiperazin-1-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-(2-(morpholine-4-yl)ethoxy)-5-Chlo)-5-chlorobenzamide,

N-(4-chlorophenyl)-2-{{[4-[(4-methylpiperazin-1-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-(3-(morpholine-4-yl)propoxy)-5-chlorobenzamide,

N-(4-chlorophenyl)-2-{{[4-[(N'-methyl-N'-(2-hydroxyethyl)amino)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-(morpholine-4-yl)-5-chlorobenzamide,

N-(4-chlorophenyl)-2-{{[4-[(N'-methyl-N'-(oxazoline-2-yl)amino)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-(morpholine-4-yl)-5-chlorobenzamide and

N-(4-chlorophenyl)-2-{{[4-[(N'-methyl-N'-(oxazoline-2-yl)amino)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide.

52. Connection on p. 49, in which D represents-N(H)-C(O)-, E represents-C(O)-N(H)-, R1denotes chlorine, R2denotes a hydrogen atom or-OR5, R3denotes a radical of the formula (i)

where r=1;

R13denotes alkyl, halo; and

R14in each case independently denotes a hydrogen atom, alkyl, halo, formyl, -N(R10R11, -C(R7)H-N(R10R11, -C(R7)H-N(R9)(R16)2, -C(O)OR5, -C(R7)H-OR5, -S(O)p-R15(where R=0-2), -C(R7)H-S(O)p-R15(where R=0-2), -C(O)N(R5R6C(R7)H-N(R5)-(R8-O)t-R5(where t=1 to 6), -C(R7)H-O-R8-CH(OH)-CH2-Or SIG5or-C(Reach independently of one another denotes hydrogen atom or alkyl, R7in each case independently denotes a hydrogen atom or alkyl, R8in each case independently denotes a straight or branched alkylenes chain, R9denotes alkyl, R10and R11each independently of one another denotes a hydrogen atom, alkyl, aryl, aralkyl, formyl, -OR5, -R8-OR5, -S(O)p-R15(where R=0-2), -R8-N(R5R6, -R8-C(O)OR5, -C(O)R15, -C(O)NH2, -C(S)NH2, -C(O)N(R5R15, -C(S)-N(R5R15, heterocyclyl [optionally substituted by alkyl, aryl, aralkyl, halo, haloalkyl, exography, -OR5, -C(O)OR5, -N(R5R6or-C(O)N(R5R6] or geterotsiklicheskikh [optionally substituted by one or more substituents selected from the group comprising alkyl, aryl, aralkyl, halo, haloalkyl, oxoprop, -OR5, -C(O)OR5, -N(R5R6and-C(O)N(R5R6] or R10and R11together with the nitrogen atom to which they are attached, form a N-heterocyclic ring containing zero to two additional heteroatoms, where N-heterocyclic ring optionally substituted by one or several is-C(O)R5and-C(O)-(R8-O)t-R5(where t=1-6), R15denotes alkyl, haloalkyl, aryl, aralkyl, -R8-OR5, -N(R5R6, -R8-N(R5R6, -R8-C(O)OR5, heterocyclyl [optionally substituted by one or more substituents selected from the group comprising alkyl, aryl, aralkyl, halo, haloalkyl, -OR5, -C(O)OR5, -N(R5R6and-C(O)N(R5R6] or geterotsiklicheskikh [optionally substituted by one or more substituents selected from the group comprising alkyl, aryl, aralkyl, halo, haloalkyl, -OR5-C(O)OR5, -N(R5R6and-C(O)N(R5R6], or R5and R15together with the nitrogen atom to which they are attached, form a N-heterocyclic ring containing zero to two additional heteroatoms, where N-heterocyclic ring optionally substituted by one or more substituents selected from the group comprising alkyl, aryl, aralkyl, amino, monoalkylamines, dialkylamines, -OR5, -C(O)OR5aminocarbonyl, monoalkylamines and dialkylaminoalkyl, and R16in each case independently denotes an alkyl, aryl, aralkyl, -R8-OR5, -R8-N(R5R6cycloalkyl and-OR5), heterocyclyl [optionally substituted by alkyl, aryl, aralkyl, halo, haloalkyl, -OR5, -C(O)OR5, -N(R5R6or-C(O)N(R5R6] or geterotsiklicheskikh [optionally substituted by one or more substituents selected from the group comprising alkyl, aryl, aralkyl, halo, haloalkyl, -OR5-C(O)OR5, -N(R5R6and-C(O)N(R5R6], or both R16together with the nitrogen atom to which they relate (and when there is no substituent R9form an aromatic N-heterocyclic ring containing zero to two additional heteroatoms, where N-heterocyclic ring optionally substituted by one or more substituents selected from the group comprising alkyl, aryl, aralkyl, -OR5, -C(O)OR5, -R8-C(O)OR5, -N(R5R6, -R8-N(R5R6, -C(O)R5-C(O)(R8-O)t-R5(where t=1-6) and -(R8-O)t-R5(where t=1-6).

53. Connection on p. 52, in which R3denotes a radical of the formula (i)

where r=1;

R13denotes alkyl, halo; and

R14in each case independently denotes a hydrogen atom or-C(R7)N-N(R10R11where R7m hydrogen, alkyl, aryl, aralkyl, formyl, -OR5, -R8-OR5, -S(O)p-R15(where R=0-2), -R8-N(R5R6, -R8-C(O)OR5, -C(O)-R15, -C(O)NH2, -C(S)NH2-C(O)N(R5R15- (S)-N(R5R15, heterocyclyl [optionally substituted by alkyl, aryl, aralkyl, halo, haloalkyl, exography, -OR5, -C(O)OR5, -N(R5R6or-C(O)N(R5R6] or geterotsiklicheskikh [optionally substituted by one or more substituents selected from the group comprising alkyl, aryl, aralkyl, halo, haloalkyl, oxoprop, -OR5, -C(O)OR5, -N(R5R6and-C(O)N(R5R6], where R5and R6each independently of one another denotes hydrogen atom or alkyl, R8in each case independently denotes a straight or branched alkylenes chain, and R15in each case denotes alkyl, haloalkyl, aryl, aralkyl, -R8-OR5, -R8-N(R5R6, -R8-C(O)OR5, heterocyclyl [optionally substituted by one or more substituents selected from the group comprising alkyl, aryl, aralkyl, halo, haloalkyl, -OR5, -C(O)OR5, -N(R5R6and-C(O)N(R5R6] or geterotsiklicheskikh [optional for alkyl, -OR5, -C(O)OR5, -N(R5R6and-C(O)N(R5R6].

54. Connection on p. 53, which is selected from the group including

N-(4-chlorophenyl)-2-{{[3-methylthiophene-2-yl]carbonyl}amino}-5-chlorobenzamide,

N-(4-chlorophenyl)-2-{{[3-[(4-methylpiperazin-1-yl)methyl]thiophene-2-yl]carbonyl}amino]-5-chlorobenzamide,

N-(4-chlorophenyl)-2-{{[5-[(dimethylamino)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-5-chlorobenzamide,

N-(4-chlorophenyl)-2-{{[3-chloro-5-[N'-methyl-N'-(2-hydroxyethyl)amino)methylthiophene-2-yl]carbonyl}amino}-5-chlorobenzamide,

N-(4-chlorophenyl)-2-{{[3-chloro-5-[N'-methyl-N'-(ethoxycarbonylmethyl)amino)methylthiophene-2-yl]carbonyl}amino}-5-chlorobenzamide,

N-(4-chlorophenyl)-2-{{[3-chloro-5-[N'-methyl-N'-(carboxymethyl)amino)methylthiophene-2-yl]carbonyl}amino}-5-chlorobenzamide,

N-(4-chlorophenyl)-2-{{[3-chloro-5-[N',N'-di(2-hydroxyethyl)amino)methyl)thiophene-2-yl]carbonyl}amino}-5-chlorobenzamide,

N-(4-chlorophenyl)-2-{{[3-chloro-5-[((N'-(3-dimethylaminophenyl)amino)methyl)thiophene-2-yl]carbonyl}amino}-5-chlorobenzamide,

N-(4-chlorophenyl)-2-{{[3-chloro-4,5-di[(n-propyl)aminomethyl)thiophene-2-yl]carbonyl}amino}-5-chlorobenzamide,

N-(4-chlorophenyl)-2-{{[3-chloro-5-[(N'-methyl-N'-(2-dimethylaminoethyl)amino)methyl)thiophene-2-yl]carbonyl}amino}-5-chlorobenzamide,

N-(4-chlorophenyl)-2-{{[3-chloro-4-[(N'-methyl-N'-(2-hydroxyethyl)amino)methyl)thiophene-2-yl]Kail]carbonyl}amino}-5-chlorobenzamide,

N-(4-chlorophenyl)-2-{{[3-chloro-4-[(N'-methyl-N'-(2-dimethylaminoethyl)amino)methyl)thiophene-2-yl]carbonyl}amino}-5-chlorobenzamide,

N-(4-chlorophenyl)-2-{{[3-chloro-4-[(N'-(3-(imidazol-1-yl)propyl)amino)methyl)thiophene-2-yl]carbonyl}amino}-5-chlorobenzamide,

N-(4-chlorophenyl)-2-{{[3-chloro-4-[(N'-methyl-N'-(3-(dimethylamino)propyl)amino)methyl)thiophene-2-yl]carbonyl}amino}-5-chlorobenzamide,

N-(4-chlorophenyl)-2-{{[3-chloro-4-[(N'-(2-methylpropyl)amino)methyl)thiophene-2-yl]carbonyl}amino}-5-chlorobenzamide,

N-(4-chlorophenyl)-2-{{[3-chloro-4-[(N'-methyl-N'-(1-methylpiperidin-4-yl)amino)methyl)thiophene-2-yl]carbonyl}amino}-5-chlorobenzamide,

N-(4-chlorophenyl)-2-{{[3-chloro-4-[(N'-(2-(morpholine-4-yl)ethyl)amino)methyl)thiophene-2-yl]carbonyl}amino}-5-chlorobenzamide,

N-(4-chlorophenyl)-2-{{[3-chloro-4-[(N'-methyl-N'-hydroxyamino)methyl)thiophene-2-yl]carbonyl}amino}-5-chlorobenzamide,

N-(4-chlorophenyl)-2-{{[3-chloro-4-[(N'-methyl-N'-(2-diethylaminoethyl)amino)methyl)thiophene-2-yl]carbonyl}amino}-5-chlorobenzamide,

N-(4-chlorophenyl)-2-{{[3-chloro-4-[(N'-(2-hydroxyethyl)-N'-(2-(morpholine-4-yl)ethyl)amino)methyl)thiophene-2-yl]carbonyl}amino}-5-chlorobenzamide and

N-(4-chlorophenyl)-2-{{[3-chloro-4-[(N'-methyl-N'-(2-(pyrrolidin-1-yl)ethyl)amino)methyl)thiophene-2-yl]carbonyl}amino}-5-chlorobenzamide.

55. Connection on p. 52, which

R3denotes a radical of the formula (i)

56. Connection on p. 55, which is selected from the group including

N-(4-chlorophenyl)-2-{{[4-methyl-3-chlorothiophene-2-yl]carbonyl}amino}-5-chlorobenzamide,

N-(4-chlorophenyl)-2-{{[3-chloro-5-[(4-(carboxymethyl)piperazine-1-yl)methyl]thiophene-2-yl]carbonyl}amino}-5-chlorobenzamide,

N-(4-chlorophenyl)-2-{{[4-[(4-methylpiperazin-1-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-5-chlorobenzamide,

N-(4-chlorophenyl)-2-{{[5-[(4-methylpiperazin-1-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-5-chlorobenzamide,

N-(4-chlorophenyl)-2-{{[3-chloro-5-[(4-(ethoxycarbonylmethyl)piperazine-1-yl)methyl]thiophene-2-yl]carbonyl}amino}-5-chlorobenzamide,

N-(4-chlorophenyl)-2-{{[3-L]methylthiophene-2-yl]carbonyl}amino}-5-chlorobenzamide,

N-(4-chlorophenyl)-2-{{[3-chloro-5-[1-(oxo)thiomorpholine-4-yl]methylthiophene-2-yl]carbonyl}amino}-5-chlorobenzamide,

N-(4-chlorophenyl)-2-{{[3-chloro-5-[(4-(((2-(2-methoxyethoxy)ethoxy)methyl)carbonyl)piperazine-1-yl)methyl]thiophene-2-yl]carbonyl}amino}-5-chlorobenzamide,

N-(4-chlorophenyl)-2-{{[4-[morpholine-4-yl]methyl-3-chlorothiophene-2-yl]carbonyl}amino}-5-chlorobenzamide,

N-(4-chlorophenyl)-2-{{[3-chloro-5-[1,1,4-three(oxo)thiomorpholine-4-yl]methylthiophene-2-yl]carbonyl}amino}-5-chlorobenzamide,

N-(4-chlorophenyl)-2-{{[3-chloro-4-[thiomorpholine-4-yl]methylthiophene-2-yl]carbonyl}amino}-5-chlorobenzamide,

N-(4-chlorophenyl)-2-{{[3-chloro-5-[(imidazol-1-yl)methyl]thiophene-2-yl]carbonyl}amino}-5-chlorobenzamide,

N-(4-chlorophenyl)-2-{{[3-chloro-5-methyl-4-[(4-methylpiperazin-1-yl)methyl]thiophene-2-yl]carbonyl}amino}-5-chlorobenzamide,

N-(4-chlorophenyl)-2-{{[3-chloro-4-methyl-5-[(4-methylpiperazin-1-yl)methyl]thiophene-2-yl]carbonyl}amino}-5-chlorobenzamide,

N-(4-chlorophenyl)-2-{{[3-chloro-4-[(4H-1,2,4-thiazol-1-yl)methyl]thiophene-2-yl]carbonyl}amino}-5-chlorobenzamide,

N-(4-chlorophenyl)-2-{{[3-chloro-4-[(imidazol-1-yl)methyl]thiophene-2-yl]carbonyl}amino}-5-chlorobenzamide,

N-(4-chlorophenyl)-2-{{[3-chloro-4-[(tetrazol-1-yl)methyl]thiophene-2-yl]carbonyl}amino}-5-chlorobenzamide,

N-(4-chlorophenyl)-2-{{[3-chloro-4-[(tetrazol-2-yl)methyl]thiophene-2-yl]carbonyl}amino}-5-chlorobenzamide,

N-(4-chlorophenyl)-2-{{[-yl)methyl]thiophene-2-yl]carbonyl}amino}-5-chlorobenzamide,

N-(4-chlorophenyl)-2-{{[3-chloro-4-[(4-(2-(2-hydroxyethoxy)ethyl)piperazine-1-yl)methyl]thiophene-2-yl]carbonyl}amino}-5-chlorobenzamide,

N-(4-chlorophenyl)-2-{{[3-chloro-4-[(1,2,3-triazole-2-yl)methyl]thiophene-2-yl]carbonyl}amino}-5-chlorobenzamide,

N-(4-chlorophenyl)-2-{{[3-chloro-4-[(4-ethylpiperazin-1-yl)methyl]thiophene-2-yl]carbonyl}amino}-5-chlorobenzamide,

N-(4-chlorophenyl)-2-{{[3-chloro-4-[(4-exmortis-4-yl)methyl]thiophene-2-yl]carbonyl}amino}-5-chlorobenzamide,

N-(4-chlorophenyl)-2-{{[3-chloro-4-[(4-acetylpiperidine-1-yl)methyl]thiophene-2-yl]carbonyl}amino}-5-chlorobenzamide and

N-(4-chlorophenyl)-2-{{[4-[(2-aminoimidazo-1-yl)methyl]-3-chlorothiophene-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide.

57. Connection on p. 52, in which R3denotes a radical of the formula (i)

where r=1;

R13represents halo or alkyl; and

R14in each case independently represents-C(R7)H-S(O)p-R15where R=0-2, R7denotes a hydrogen atom or alkyl, and R15denotes alkyl, -R8-N(R5R6or-R8-C(O)OR5where R5and R6each independently of one another denotes hydrogen atom or alkyl, and R8in each case independently denotes a straight or branched alkylenes chain.

58. Connection on p. 57, kotarbinski,

N-(4-chlorophenyl)-2-{{[3-chloro-5-(((methoxycarbonylmethyl)thio)methyl)thiophene-2-yl]carbonyl}amino}-5-chlorobenzamide,

N-(4-chlorophenyl)-2-{{[3-chloro-5-(((methoxycarbonylmethyl)sulfinil)methyl)thiophene-2-yl]carbonyl}amino}-5-chlorobenzamide,

N-(4-chlorophenyl)-2-{{[3-chloro-5-((methylsulfonyl)methyl)thiophene-2-yl]carbonyl}amino}-5-chlorobenzamide,

N-(4-chlorophenyl)-2-{{[3-chloro-5-((carbonylmethyl)thio)methyl)thiophene-2-yl]carbonyl}amino}-5-chlorobenzamide,

N-(4-chlorophenyl)-2-{{[3-chloro-5-((methylsulphonyl)methyl)thiophene-2-yl]carbonyl}amino}-5-chlorobenzamide,

N-(4-chlorophenyl)-2-{{[3-chloro-5-(((2-(dimethylamino)ethyl)thio)methyl)thiophene-2-yl]carbonyl}amino}-5-chlorobenzamide,

N-(4-chlorophenyl)-2-{{[3-chloro-5-(((2-(dimethylamino)ethyl)sulfinil)methyl)thiophene-2-yl]carbonyl}amino}-5-chlorobenzamide,

N-(4-chlorophenyl)-2-{{[3-chloro-4-((methylthio)methyl)thiophene-2-yl]carbonyl}amino}-5-chlorobenzamide,

N-(4-chlorophenyl)-2-{{[3-chloro-4-(((methoxycarbonylmethyl)thio)methyl)thiophene-2-yl]carbonyl}amino}-5-chlorobenzamide,

N-(4-chlorophenyl)-2-{{[3-chloro-4-(((2-(dimethylamino)ethyl)thio)methyl)thiophene-2-yl]carbonyl}amino}-5-chlorobenzamide,

N-(4-chlorophenyl)-2-{{[3-chloro-4-((methylsulphonyl)methyl)thiophene-2-yl]carbonyl}amino}-5-chlorobenzamide and

N-(4-chlorophenyl)-2-{{[3-chloro-4-((methylsulfonyl)methyl)thiophene-2-yl]carbonyl}amino}-5-chlorobenzamide.

59. Connection A13
represents halo or alkyl; and

R14in each case independently denotes formyl, -N(R10R11, -C(O)OR5, -C(R7)H-OR5or-C(O)N(R5R6where R5and R6each independently of one another denotes hydrogen atom or alkyl, R7denotes a hydrogen atom or alkyl, and R10and R11each independently of one another denotes hydrogen atom or alkyl.

60. Connection on p. 59, which is selected from the group including

N-(4-chlorophenyl)-2-{{[3-chloro-5-carboxamide-2-yl]carbonyl)amino}-5-chlorobenzamide and

N-(4-chlorophenyl)-2-{{[3-chloro-4-(hydroxymethyl)thiophene-2-yl]carbonyl}amino}-5-chlorobenzamide.

61. Connection on p. 52, in which R3denotes a radical of the formula (i)

where r=1;

R13denotes alkyl, halo or-OR5where R5denotes alkyl; and

R14in each case independently denotes a hydrogen atom, halo, -C(R7)H-N(R9)(R16)2, -S(O)p-R15-C(R7)N-N(R5)-(R8-O)t-R5(where t=1 to 6), -C(R7)HO-R8-CH(OH)-CH2-OR5or-C(R7)N-N(R5)-R8-[CH(OH)]t-CH2-Or SIG5(where t=1-6), where R5and R6each independent8independently of one another denotes a straight or branched alkylenes chain, R10and R11each independently of one another denotes a hydrogen atom, alkyl or-R8-OR5where R8in each case independently denotes a straight or branched alkylenes chain, and R5denotes a hydrogen atom or alkyl, R15denotes alkyl or-N(R5R6and R16in each case independently denotes an alkyl, aryl, aralkyl, -R8-OR5, -R8-N(R5R6cycloalkyl (optionally substituted by one or more substituents selected from the group comprising alkyl, halo and-OR5), heterocyclyl [optionally substituted by alkyl, aryl, aralkyl, halo, haloalkyl, -OR5, -C(O)OR5, -N(R5R6or-C(O)N(R5R6] or geterotsiklicheskikh [optionally substituted by one or more substituents selected from the group comprising alkyl, aryl, aralkyl, halo, haloalkyl, -OR5, -C(O)OR5, -N(R5R6and-C(O)N(R5R6], or both R16together with the nitrogen atom to which they relate (and when there is no substituent R9form an aromatic N-heterophilically ring containing from zero to two on what estately, selected from the group comprising alkyl, aryl, aralkyl, -OR5, -C(O)OR5, -R8-C(O)OR5, -N(R5R6, -R8-N(R5R6-C(O)R5-C(O)-(R8-O)t-R5(where t=1-6) and -(R8-O)t-R5(where t=1-6).

62. Connection on p. 61, which is selected from the group including

N-(4-chlorophenyl)-2-{{[3-chloro-4-[(N',N'-dimethyl-N'-(2-hydroxyethyl)ammonium)methyl]thiophene-2-yl]carbonyl}amino]-5-chlorobenzamide,

N-(4-chlorophenyl)-2-{{[3-chloro-4-[(((2-hydroxyethoxy)ethyl)amino)-methyl]thiophene-2-yl]carbonyl}amino}-5-chlorobenzamide,

N-(4-chlorophenyl)-2-{{[3-chloro-4-[(2-(2-methoxyethoxy)ethoxy)methyl]thiophene-2-yl]carbonyl}amino}-5-chlorobenzamide,

N-(4-chlorophenyl)-2-{{[3-chloro-4-[(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)methyl]thiophene-2-yl]carbonyl}amino}-5-chlorobenzamide,

N-(4-chlorophenyl)-2-{{[3-chloro-4-[(2-methoxyethoxy)methyl]thiophene-2-yl]carbonyl}amino}-5-chlorobenzamide,

N-(4-chlorophenyl)-2-{{[3-chloro-4-[(N',N'-dimethyl-N'-(3-hydroxypropyl)ammonium)methyl]thiophene-2-yl]carbonyl}amino}-5-chlorobenzamide,

N-(4-chlorophenyl)-2-{{[3-chloro-4-[(N'-methyl-N'-(2,3-dihydroxypropyl)amino)methyl]thiophene-2-yl]carbonyl}amino}-5-chlorobenzamide

N-(4-chlorophenyl)-2-{{[3-chloro-4-[(N'-methyl-N'-(2,3,4,5,6-pentahydroxy)amino)methyl]thiophene-2-yl]carbonyl}amino}-5-chlorobenzamide,

N-(4-chlorophenyl)-2-{{[3-chloro-4-[(ENT-4-[methylsulphonyl]thiophene-2-yl]carbonyl}amino}-5-methylbenzamide,

N-(4-chlorophenyl)-2-{{[3-chlorothiophene-2-yl]carbonyl}amino}-5-methylbenzamide,

N-(4-chlorophenyl)-2-{{[3-bromothiophene-2-yl]carbonyl}amino}-5-methylbenzamide,

N-(4-chlorophenyl)-2-{{[3-chloro-4-[(1-methylethyl)sulfonyl]thiophene-2-yl]carbonyl}amino}-5-methylbenzamide,

N-(4-chlorophenyl)-2-{{[4-[methylamino)sulfonyl]-3-methylthiophene-2-yl]carbonyl}amino}-5-methylbenzamide and

N-(4-chlorophenyl)-2-{{[3-methoxythiophene-2-yl]carbonyl}amino}-5-methylbenzamide.

63. Connection on p. 1, And which represents =CH - or =N-, m=1-3, n=1-4, D represents-N(H)-C(O) -, or-N(H)-CH2(and a nitrogen atom directly linked to the phenyl ring containing the substituents R1and R2), E denotes-C(O)-N(H)- (where the nitrogen atom linked to an aromatic ring containing substituent R4), R1in each case independently denotes a hydrogen atom, halo, haloalkyl, hydroxy, R2denotes a hydrogen atom, alkyl, aryl, aralkyl, halo, haloalkyl, cyano, -OR5, -S(O)p-R9(where R=0-2), -C(O)OR5, -OC(O)-R5, -C(O)N(R5R6, -N(R10R11, -C(R7)H-OR5, -C(R7)H-S(O)p-R9(where R=0-2), -O-R8-S(O)p-R9(where R=0-2), -C(R7)N-N(R5R6, -O-R8-CH(OH)-CH2-N(R10R11, -O-R8-N(R10R11, -O-R8p>, -O-R8-C(O)OR5, -N(R5)-R8-N(R10R11, -S(O)p-R8-N(R5R6(where R=0-2), -S(O)p-R8-C(O)OR5(where R=0-2), or-N(R5)-CH(R12)-C(O)OR5, R3denotes a radical of the formula (ii)

where v=1-4;

R13denotes a hydrogen atom, alkyl, halo, haloalkyl; and

R14in each case independently denotes a hydrogen atom, alkyl, halo, formyl, acetyl, -N(R10R11-C(R7)N-N(R10R11-C(R7)H-N(R9)(R16)2, -N(R5)-R8-C(O)OR5, -C(R7)H-N(R5)-R8-C(O)OR5, -C(O)OR5, -OR5, -C(R7)H-OR5, -S(O)pR15(where R=0-2), -C(R7)H-S(O)p-R15(where R=0-2), -S(O)p-N(R5R6(where R=0-2), -C(O)N(R5R6, -C(R7)N-N(R5)-(R8-O)t-R5(where t=1 to 6), -C(R7)H-O-(R8-O)t-R5(where t=1 to 6), -O-R8-CH(OH)CH2-OR5, -C(R7)H-O-R8-CH(OH)-CH2-OR5-C(R7)N-N(R5)-R8- (CH) - OH]t-CH2-Or SIG5(where t=1 to 6), -C(R7)N-N(R5)S(O)2-N(R10R11, -C(R7)H-N(R10)-C(NR17)-N(R10R11or-C(R7)N-N(R10)-C(NR175, -C(O)OR5, -N(R5R6, -C(O)N(R5R6or-R8-N(R5R6, R5and R6each independently of one another denotes a hydrogen atom, alkyl, aryl or aralkyl, R7in each case independently denotes a hydrogen atom or alkyl, R8in each case independently denotes a straight or branched alkylenes or alkylidene chain, R9in each case independently denotes an alkyl, aryl or aralkyl, R10and R11each independently of one another denotes a hydrogen atom, alkyl, aryl, aralkyl, formyl, -OR5, -R8-OR5, -S(O)p-R15(where R=0-2), -R8-N(R5R6, -R8-C(O)OR5, -C(O)R15-C(O)NH2, -C(S)NH2-C(O)N(R5R15- (S)-N(R5R15cycloalkyl (optionally substituted by one or more substituents selected from the group comprising alkyl, halo and-OR5), heterocyclyl [optionally substituted by alkyl, aryl, aralkyl, halo, haloalkyl, exography, -OR5, -C(O)OR5, -N(R5R6or-C(O)N(R5R6] or geterotsiklicheskikh [optionally substituted by one or more substituents selected from the group comprising alkyl, aryl, aralkyl, halo, g is p> together with the nitrogen atom to which they are attached, form a N-heterocyclic ring containing zero to two additional heteroatoms, where N-heterocyclic ring optionally substituted by one or more substituents selected from the group comprising alkyl, aryl, aralkyl, oxoprop, =N(R17), -OR5, -C(O)OR5, -R8-C(O)OR5, -N(R5R6, -R8-N(R5R6, -C(O)R5, -C(O)-(R8-O)t-R5(where t=1-6) and -(R8-O)t-R5(where t=1-6), R12denotes the side chain of-amino acids, R15denotes alkyl, haloalkyl, aryl, aralkyl, -R8-OR5, -N(R5R6, -R8-N(R5R6, -R8-C(O)OR5, heterocyclyl [optionally substituted by one or more substituents selected from the group comprising alkyl, aryl, aralkyl, halo, haloalkyl, -OR5, -C(O)OR5, -N(R5R6and-C(O)N(R5R6] or geterotsiklicheskikh [optionally substituted by one or more substituents selected from the group comprising alkyl, aryl, aralkyl, halo, haloalkyl, -OR5, -C(O)OR5, -N(R5R6and-C(O)N(R5R6] or R5and R15together with the nitrogen atom, with katorga N-heterocyclic ring optionally substituted by one or more substituents, selected from the group comprising alkyl, aryl, aralkyl, amino, monoalkylamines, dialkylamines, -OR5-C(O)OR5aminocarbonyl, monoalkylamines and dialkylaminoalkyl, R16in each case independently denotes an alkyl, aryl, aralkyl, -R8-OR5, -R8-N(R5R6cycloalkyl (optionally substituted by one or more substituents selected from the group comprising alkyl, halo and-OR5), heterocyclyl [optionally substituted by alkyl, aryl, aralkyl, halo, haloalkyl, -OR5, -C(O)OR5, -N(R5R6or-C(O)N(R5R6] or geterotsiklicheskikh [optionally substituted by one or more substituents selected from the group comprising alkyl, aryl, aralkyl, halo, haloalkyl, -OR5, -C(O)OR5, -N(R5R6and-C(O)N(R5R6], or both R16together with the nitrogen atom to which they relate (and when there is no substituent R9form an aromatic N-heterocyclic ring containing zero to two additional heteroatoms, where N-heterocyclic ring optionally substituted by one or more substituents selected from the group comprising alkyl, aryl, aralkyl, -OR5, -C(O)OR5, -p> (where t=1-6) and -(R8-O)t-R5(where t=1-6), R17in each case independently denotes a hydrogen atom, alkyl, aryl, aralkyl, cyano, -OR5, -R8-OR5, -C(O)OR5, -R8-C(O)OR5, -C(O)N(R5R6or-R8-C(O)-N(R5R6.

64. Connection on p. 63, which is selected from the group including

N-phenyl-2-{{[3-chlorobenzo[b]Tien-2-yl]carbonyl}amino}-5-methylbenzamide,

N-(pyridine-3-yl)-2-{{[3-chlorobenzo[b]Tien-2-yl]carbonyl}amino}-5-methylbenzamide,

N-(pyridine-2-yl)-2-{{[3-chlorobenzo[b]Tien-2-yl]carbonyl}amino]-5-methylbenzamide,

N-(4-methoxyphenyl)-2-{{[3-chlorobenzo[b]Tien-2-yl]carbonyl]amino}-5-methylbenzamide,

N-(3-forfinal)-2-{{[3-chlorobenzo[b]Tien-2-yl]carbonyl]amino]-5-methylbenzamide,

N-(4-chlorophenyl)-2-{{[3-chlorobenzo[b]Tien-2-yl]carbonyl]amino]-5-methylbenzamide,

N-(4-bromophenyl)-2-{{[3-chlorobenzo[b]Tien-2-yl]carbonyl]amino]-5-methylbenzamide,

N-(5-chloropyridin-2-yl)-2-{{[3-chlorobenzo[b]Tien-2-yl]carbonyl}amino}-5-methylbenzamide,

N-(3-chlorophenyl)-2-{{[3-chlorobenzo[b]Tien-2-yl]carbonyl}amino}-5-methylbenzamide,

N-(3-were)-2-{{[3-chlorobenzo[b]Tien-2-yl]carbonyl}amino}-5-methylbenzamide,

N-(4-chloro-2-were)-2-{{[3-chlorobenzo[b]Tien-2-yl]carbonyl}amino}-5-methylbenzamide,

N-(4-cyanophenyl)-2-{{[3-chlorobenzo[b]Tien-2-yl]charpenel)-2-{{[3-methylbenzo[b]Tien-2-yl]carbonyl}amino}-5-methylbenzamide,

N-(4-chlorophenyl)-2-{{[3-methoxybenzo[b]Tien-2-yl]carbonyl}amino}-5-methylbenzamide,

N-(4-forfinal)-2-{{[3-chlorobenzo[b]Tien-2-yl]carbonyl}amino}benzamide,

N-(4-forfinal)-2-{{[3-chlorobenzo[b]Tien-2-yl]carbonyl}amino}-5-methoxybenzamide,

N-(4-bromophenyl)-2-{{[3-chlorobenzo[b]Tien-2-yl]carbonyl}amino}-5-chlorobenzamide,

N-phenyl-2-{{[3-chlorobenzo[b]Tien-2-yl]carbonyl}amino}-3-methylbenzamide,

N-(4-forfinal)-2-{{[3-chlorobenzo[b]Tien-2-yl]carbonyl}amino}-5-(pyrrolidin-1-yl)methylbenzamide,

N-(4-chlorophenyl)-2-{{[3-chlorobenzo[b]Tien-2-yl]carbonyl}amino}-4-(trifluoromethyl)benzamid,

N-(4-forfinal)-2-{{[3-chlorobenzo[b]Tien-2-yl]carbonyl}amino}-5-(dimethylamino)methylbenzamide,

N-(4-chlorophenyl)-2-{{[3-chlorobenzo[b]Tien-2-yl]carbonyl}amino}-5-(4-methylpiperazin-1-yl)benzamid,

N-(4-forfinal)-2-{{[3-chlorobenzo[b]Tien-2-yl]carbonyl}amino}-5-(amino)methylbenzamide,

N-(4-chlorophenyl)-2-{{[3-chlorobenzo[b]Tien-2-yl]carbonyl}amino}-5-hydroxybenzamide,

N-phenyl-2-{{[3-chlorobenzo[b]Tien-2-yl]carbonyl}amino}-4,5-dimethoxybenzamide,

N-phenyl-2-{{[3-chlorobenzo[b]Tien-2-yl]carbonyl}amino}-4,5-dihydroxybenzamide,

N-(4-chlorophenyl)-2-{{[3-chlorobenzo[b]Tien-2-yl]carbonyl}amino}-5-perbenzoic,

N-(4-chlorophenyl)-2-{{[3-chlorobenzo[b]Tien-2-yl]carbonyl}amino}-3-chlorobenzamide,

N-phenyl-2-{{[3-chlorobenzo[b]Tien-2-yl]-(4-chlorophenyl)-2-{{[3-chlorobenzo[b]Tien-2-yl]carbonyl}amino}-4-perbenzoic,

N-(4-chlorophenyl)-2-{{[3-chlorobenzo[b]Tien-2-yl]carbonyl}amino}-4-chlorobenzamide,

N-(4-chlorophenyl-2-{{[3-chlorobenzo[b]Tien-2-yl]carbonyl}amino}-3-methoxybenzamide,

N-(4-chlorophenyl)-2-{{[3-chlorobenzo[b]Tien-2-yl]carbonyl}amino}-6-perbenzoic,

N-(4-chlorophenyl)-2-{{[3-chlorobenzo[b]Tien-2-yl]carbonyl}amino}-3-hydroxybenzamide,

N-(4-chlorophenyl)-2-{{[3-chlorobenzo[b]Tien-2-yl]carbonyl}amino}-4-methylbenzamide,

N-(4-chlorophenyl)-2-{{[3-chlorobenzo[b]Tien-2-yl]carbonyl}amino}-3-(etoxycarbonyl)methoxybenzamide,

N-(4-chlorophenyl)-2-{{[3-chlorobenzo[b]Tien-2-yl]carbonyl}amino}-4,5-hydroxybenzamide,

N-(4-chlorophenyl)-2-{{[3-chlorobenzo[b]Tien-2-yl]carbonyl}amino}-4,5-dimethoxybenzamide,

N-(4-chlorophenyl)-2-{{[3-chlorobenzo[b]Tien-2-yl]carbonyl}amino}benzamide,

N-(4-chlorophenyl)-2-{{[3-chlorobenzo[b]Tien-2-yl]carbonyl}amino}-5-aminobenzamide,

N-(4-chlorophenyl)-2-{{[3-chlorobenzo[b]Tien-2-yl]carbonyl}amino}-4-methyl-5-chlorobenzamide,

N-(4-chlorophenyl)-2-{{[3-chlorobenzo[b]Tien-2-yl]carbonyl}amino}-3-methoxy-5-chlorobenzamide,

N-(4-chlorophenyl)-2-{{[3-chlorobenzo[b]Tien-2-yl]carbonyl}amino}-3-methylbenzamide,

N-(4-chlorophenyl)-2-{{[3-chlorobenzo[b]Tien-2-yl]carbonyl}amino}-3-methyl-5-chlorobenzamide,

N-(4-chlorophenyl)-2-{{[3-chlorobenzo[b]Tien-2-yl]carbonyl}amino}-4-fluoro-5-chlorobenzamide,

N-(4-chlorophenyl)-2-{{[3-chlorobenzo[b]Tien-2-benzamid,

N-(4-chlorophenyl)-2-{{[3-chlorobenzo[b]Tien-2-yl]carbonyl}amino}-4-(N'-methyl-N'-(3-(dimethylamino)propylamino-5-perbenzoic,

N-(4-chlorophenyl)-2-{{[3-chlorobenzo[b]Tien-2-yl]carbonyl}amino}-4-(4-methylpiperazin-1-yl)-5-perbenzoic,

N-(4-chlorophenyl)-2-{{[3-chlorobenzo[b]Tien-2-yl]carbonyl}amino}-4-((3-(4-methylpiperazin-1-yl)propyl)amino)-5-perbenzoic,

N-(4-chlorophenyl)-2-{{[3-chloro-6-methylbenzo[b]Tien-2-yl]carbonyl}amino}-5-chlorobenzamide,

N-(4-chlorophenyl)-2-{{[3-methylbenzo[b]Tien-2-yl]carbonyl}amino}-5-chlorobenzamide,

N-(4-chlorophenyl)-2-{{[3-(dimethylamino)methylbenzo[b]Tien-2-yl]carbonyl}amino}-5-chlorobenzamide,

N-(4-chlorophenyl)-2-{{[3-chloro-6-(dimethylamino)methylbenzo[b]Tien-2-yl]carbonyl}amino}-5-chlorobenzamide,

N-(4-chlorophenyl)-2-{{[3-(4-methylpiperazin-1-yl)methylbenzo[b]Tien-2-yl]carbonyl}amino}-5-chlorobenzamide,

N-(4-chlorophenyl)-2-{{[3-chloro-6-(4-methylpiperazin-1-yl)methyl-benzo[b]Tien-2-yl]carbonyl}amino}-5-chlorobenzamide,

N-(4-chlorophenyl)-2-{{[3-chloro-6-(4-(carboxymethyl)piperazine-1-yl)methylbenzo[b]Tien-2-yl]carbonyl}amino}-5-chlorobenzamide,

N-(4-chlorophenyl)-2-{{[3-chloro-6-((methoxycarbonyl)methylthio)methylbenzo[b]Tien-2-yl]carbonyl}amino}-5-chlorobenzamide,

N-(4-chlorophenyl)-2-{{[3-chlorobenzo[b]Tien-2-yl]carbonyl}amino}-5-chlorobenzamide,

N-(5-chloropyridin-2-yl)-2-{{[4-((4-methylpiperazin-1-yl)methyl) - Rev. l)-2-{{[4-[N'-methyl-N'-(2-(dimethylamino)ethyl)amino]-3-chlorothiophene-2-yl]carbonyl}amino}-3-chloro-5-(N'-methyl-N'-(etoxycarbonyl)methylamino)benzamide,

N-phenyl-2-{{[3-chlorobenzo[b]Tien-2-yl]carbonyl}amino}-5-hydroxy-4-((1,1-dimethylethyl)carbonyl)oxybenzone and

N'-(4-chlorophenyl)-2-{[3-methylbenzo[b]Tien-2-yl]methyl}amino-5-benzamide.

65. Pharmaceutical composition, which can be used in the treatment of a person in a morbid condition, characterized by thrombotic activity, which includes a therapeutically effective amount of the compounds of formula (I)

where a represents =CH - or =N-;

m=1-3;

n=1-4;

D represents-N(R5)-C(Z) -, or-N(R5)-S(O)p- (where R=0-2, Z represents an oxygen atom, sulfur or N2and the nitrogen atom is directly linked to the phenyl ring containing the substituents R1and R2);

E represents-C(Z)-N(R5)- or-S(O)p-N(R5)- (where p=0-2, Z represents an oxygen atom, sulfur or N2and the nitrogen atom may be associated with the phenyl ring containing the substituents R1and R2or aromatic ring containing substituent R4);

R1in each case independently denotes a hydrogen atom, alkyl, aryl, aralkyl, halo, haloalkyl, hydroxy;

R2denotes a hydrogen atom, alkyl, aryl, aralkyl, halo, haloalkyl, cyano, -OR5, -S(O)p7
)H-OR5, -C(R7)H-R8-OR5, -C(R7)H-S(O)p-R9(where R=0-2), -C(R7)H-R8-S(O)p-R9(where R=0-2), -O-R8-S(O)p-R9(where R=0-2), -C(R7)H-N(R5R6, -C(R7)H-R8-N(R5R6, -O-R8-CH(OH)-CH2-N(R10R11, -O-R8-N(R10R11, -O-R8-OC(O)R5, -O-R8-CH(OH)-CH2-OR5, -O-(R8O)t-R5(where t=1 to 6), -O-(R8-O)t-R19(where t=1 to 6), -O-R8-C(O)R5, -O-R8-C(O)R19, -O-R8-C(O)OR5, -N(R5)-R8-N(R10R11, -S(O)p-R8-N(R5R6(where R=0-2), -S(O)p-R8-C(O)OR5(where R=0-2), or-N(R5)-CH(R12)-C(O)OR5, R3denotes a radical of the formula (i)

where r=1;

R13denotes a hydrogen atom, alkyl, halo, haloalkyl; and

R14in each case independently denotes a hydrogen atom, alkyl, halo, formyl, acetyl, cyano, -R8-CN, -N(R10R11-C(R7)H-N(R10R11, -C(R7)H-R8-N(R10R11, -C(R7)H-N(R9)(R16)2, -C(R7)H-R8-N(R9)(R16)2, -C(O)OR5-C(R7

, -C(R7)H-O-R15, -S(O)p-R15(where R=0-2), -C(R7)H-S(O)p-R15(where R=0-2), -C(R7)H-R8-S(O)p-R15(where R=0-2), -S(O)p-N(R5R6(where R=0-2), -C(O)N(R5R6, -C(R7)H-C(O)N(R5R6, -C(R7)H-R8-C(O)-N(R5R6, -C(R7)N-N(R5)-(R8-O)t-R5(where t=1 to 6), -C(R7)H-R8N(R5)-(R8-O)t-R5(where t=1 to 6), -O-R8-CH(OH)-CH2-OR5, -C(R7)H-O-R8-CH(OH)-CH2Or SIG5, -C(R7)H-N(R5)-R8-[CH(-OH)]t-CH2-OR5(where t=1 to 6), -C(R7)H-N(R5)-S(O)2-N(R10R11, -C(R7)H-N(R10)C(NR17)-N(R10R11-C(R7)N-N(R10)-C(N-R17)-R10, -C(NR17)-N(R5R6, -C(R7)H-C(NR17)-N(R5R6, -C(R7)H-O-N(R5R6, heterocyclyl [where heterocyclyl radical is not associated with the radical of the formula (i) via a nitrogen atom and optionally substituted by alkyl, aryl, aralkyl, halo, haloalkyl, exography, -OR5, -C(O)OR5, -N(R5R6or-C(O)N(R5R6] or geterotsiklicheskikh [where heterocyclyl radical is not associated with the alkyl moiety through a nitrogen atom and optionally substituted by one or several , -C(O)OR5, -N(R5R6and-C(O)N(R5R6], or R3denotes a radical of the formula (ii)

where v=1-4;

R13matter listed for formula (i);

R14matter listed for formula (i),

R4in each case independently denotes a hydrogen atom, alkyl, halo, haloalkyl, cyano-, nitro-group, -OR5, -C(O)OR5, -N(R5R6, -C(O)N(R5R6or-R8-N(R5R6,

R5and R6each independently of one another denotes a hydrogen atom, alkyl, aryl or aralkyl, R7in each case independently denotes a hydrogen atom or alkyl, R8in each case independently denotes a straight or branched alkylenes, alkylidene or alkylidene chain, R9in each case independently denotes an alkyl, aryl or aralkyl, R10and R11each independently of one another denotes a hydrogen atom, alkyl, haloalkyl, aryl, aralkyl, formyl, cyano, -R8-CN, -OR5, -R8-OR5, -S(O)p-R15(where R=0-2), -R8-S(O)p-R15(where R=0-2), -N(R5R6, -R8-N(R5R6, -R8-C(O)OR5, -C(O)-R15, -C(O)NH2, -R8-C(O)NH2, -C(S)NH2)-C(O)H, -R8-N(R5)-C(O)R15-C(O)O-R8-N(R5R6:- C[N(R5R6]=C(R18R10, -R8-N(R5)-P(O)(OR5)2cycloalkyl (optionally substituted by one or more substituents selected from the group comprising alkyl, halo and-OR5), heterocyclyl [optionally substituted by alkyl, aryl, aralkyl, halo, haloalkyl, exography, -OR5, -R8-OR5, -C(O)OR5, -S(O)p-R9(where R=0-2), -R8-S(O)p-R9(where R=0-2), -N(R5R6or-C(O)N(R5R6] or geterotsiklicheskikh [optionally substituted by one or more substituents selected from the group comprising alkyl, aryl, aralkyl, halo, haloalkyl, oxoprop, -OR5, -R8-OR5, -C(O)OR5, -S(O)p-R9(where R=0-2), -R8-S(O)p-R9(where R=0-2), -N(R5R6and-C(O)N(R5R6] or R10and R11together with the nitrogen atom to which they are attached, form a N-heterocyclic ring containing zero to two additional heteroatoms, where N-heterocyclic ring optionally substituted by one or more substituents selected from the group comprising alkyl, halo, haloalkyl, aryl, aralkyl, oxo - nitro-, qi is sup>5
R6-C(O)N(R5R6, -R8-C(O)N(R5R6, -N(R5)-N(R5R6, -C(O)R5-C(O)-(R8-O)t-R5(where t=1 to 6), -S(O)p-R9(where R=0-2), -R8-S(O)p-R9(where R=0-2), -(R8O)t-R5(where t=1-6) and heterocyclyl [optionally substituted by one or more substituents selected from the group comprising alkyl, aryl, aralkyl, halo, haloalkyl, -OR5, -C(O)OR5, -N(R5R6and-C(O)N(R5R6], R12denotes the side chain of-amino acids, R15in each case independently denotes an alkyl, cycloalkyl, haloalkyl, aryl, aralkyl, -R8-O-C(O)-R5, -R8-OR5, -N(R5R6, -R8-N(R5R6, -R8-C(O)OR5, heterocyclyl [optionally substituted by one or more substituents selected from the group comprising alkyl, aryl, aralkyl, halo, haloalkyl, -OR5, -R8-OR5-C(O)OR5, -N(R5R6and-C(O)N(R5R6] or geterotsiklicheskikh [optionally substituted by one or more substituents selected from the group comprising alkyl, aryl, aralkyl, halo, haloalkyl, -OR5, -R8-OR5, -C(O)OR5, -N(R5R6and-C(O)N(R ring, containing from zero to two additional heteroatoms, where N-heterocyclic ring optionally substituted by one or more substituents selected from the group comprising alkyl, aryl, aralkyl, amino, monoalkylamines, dialkylamines, -OR5, -C(O)OR5aminocarbonyl, monoalkylamines and dialkylaminoalkyl, R16in each case independently denotes an alkyl, aryl, aralkyl, -R8-OR5, -R8-N(R5R6cycloalkyl (optionally substituted by one or more substituents selected from the group comprising alkyl, halo and-OR5), heterocyclyl [optionally substituted by alkyl, aryl, aralkyl, halo, haloalkyl, -OR5, -C(O)OR5, -N(R5R6or-C(O)N(R5R6] or geterotsiklicheskikh [optionally substituted by one or more substituents selected from the group comprising alkyl, aryl, aralkyl, halo, haloalkyl, -OR5, -C(O)OR5, -N(R5R6and-C(O)N(R5R6], or both R16together with the nitrogen atom to which they relate (and when there is no substituent R9form an aromatic N-heterocyclic ring containing zero to two additional heteroatoms, where N-heterocyclics, aryl, aralkyl, -OR5, -C(O)OR5, -R8-C(O)OR5, -N(R5R6, -R8-N(R5R6, -C(O)R5, -C(O)(R8-O)t-R5(where t=1-6) and -(R8-O)t-R5(where t=1-6), R17in each case independently denotes a hydrogen atom, alkyl, aryl, aralkyl, cyano, -OR5, -R8-OR5, -C(O)OR5, -R8-C(O)OR5or-R8-C(O)-N(R5R6, R18denotes a hydrogen atom, alkyl, aryl, aralkyl, cyano, -C(O)or SIG5or NO2and R19in each case denotes cycloalkyl, haloalkyl, -R8-OR5, -R8-N(R5R6, -R8-C(O)OR5, -R8-C(O)N(R5R6, heterocyclyl [optionally substituted by alkyl, aryl, aralkyl, halo, haloalkyl, -OR5, -C(O)OR5, -N(R5R6or-C(O)N(R5R6] or geterotsiklicheskikh [optionally substituted by one or more substituents selected from the group comprising alkyl, aryl, aralkyl, halo, haloalkyl, -OR5, -C(O)OR5, -N(R5R6and-C(O)N(R5R6],

moreover, the "aryl" is called a phenyl or nattily radical, optionally substituted by alkyl, halogen, -OR5(where R5means hydrogen or alkyl); "heterocycling up to five heteroatoms, selected from the group comprising nitrogen, oxygen and sulfur, and nitrogen atoms or sulfur in the heterocyclic ring radical may be optionally oxidized to various oxidation States, the nitrogen atom can be optionally and stereoselectivity, and the ring radical may be partially or fully saturated or aromatic; "heterocyclyl" called heterocyclic ring radical, which is described above, except that the heterocyclic ring radical may be linked to the main structure via any heteroatom or carbon atom, resulting in a stable structure,

in the form of a single stereoisomer, or mixtures thereof, or its pharmaceutically acceptable salt and pharmaceutically acceptable filler.

66. The method of treatment of a person in a morbid condition, characterized by thrombotic activity, introducing a therapeutically effective amount of the compounds on p. 1 of formula (I)

where a represents =CH - or =N-;

m=1-3;

n=1-4;

D represents-N(R5)-C(Z) -, or-N(R5)-S(O)p- (where R=0-2, Z represents an oxygen atom or sulfur or N2and the nitrogen atom right of swatr
-N(R5)- (where p=0-2, Z represents an oxygen atom or sulfur or N2and the nitrogen atom may be associated with the phenyl ring containing the substituents R1and R2or aromatic ring containing substituent R4);

R1in each case independently denotes a hydrogen atom, halo, haloalkyl, hydroxy;

R2denotes a hydrogen atom, alkyl, aryl, aralkyl, halo, haloalkyl, cyano, -OR5, -S(O)p-R9(where R=0-2), -C(O)OR5-C(O)N(R5R6, -N(R10R11-C(R7)N-N(R10R11, -C(R7)H-OR5, -C(R7)H-R8-OR5, -C(R7)H-S(O)p-R9(where R=0-2), -C(R7)H-R8-S(O)pR9(where R=0-2), -O-R8-S(O)p-R9(where R=0-2), -C(R7)N-N(R5R6, -C(R7)H-R8-N(R5R6, -O-R8-CH(OH)-CH2-N(R10R11, -O-R8-N(R10R11, -O-R8-OC(O)R5, -O-R8-CH(OH)-CH2-OR5, -O-(R8-O)t-R5(where t=1 to 6), -O-(R8-O)t-R19(where t=1 to 6), -O-R8-C(O)R5, -O-R8-C(O)R19, -O-R8-C(O)OR5N(R5)-R8-N(R10R11, -S(O)p-R8-N(R5R6(where R=0-2), -S(O)p-R8-C(O)OR5(where R=0-2), or-N(R

where r=1;

R13denotes a hydrogen atom, alkyl, halo, haloalkyl, -N(R5R6, -C(R7)H-N(R5R6, -OR5, -R8-OR5, -S(O)p-R8-N(R5R6(where R=0-2), or geterotsiklicheskikh (where the heterocyclic ring optionally substituted by one or more substituents selected from the group comprising alkyl, halo, aralkyl, nitro - and cyanopropyl);

R14in each case independently denotes a hydrogen atom, alkyl, halo, formyl, acetyl, cyano, -R8-CN, -N(R10R11, -C(R7)H-N(R10R11, -C(R7)H-R8-N(R10R11, -C(R7)H-N(R9)(Rl6)2, -C(R7)H-R8-N(R9)(Rl6)2, -C(O)OR5, -C(R7)H-C(O)OR5, -C(R7)H-R8-C(O)OR5, -OR5, -C(R7)H-OR5, -C(R7)H-R8-OR5, -C(R7)H-O-R15, -S(O)p-R15(where R=0-2), -C(R7)H-S(O)p-R15(where R=0-2), -C(R7)H-R8-S(O)p-R15(where R=0-2), -S(O)p-N(R5R6(where R=0-2), -C(O)N(R5R6, -C(R7)H-C(O)N(R5R6, -C(R7)H-R8-C(O)N(R5R6, -C(R7)H-N(R5)-(R8-O)t-R5(where t=17
)H-O-R8-CH(OH)-CH2-OR5, -C(R7)H-N(R5)-R8-[CH(OH)]t-NH2-OR5(where t=1 to 6), -C(R7)H-N(R5)-S(O)2-N(R10R11, -C(R7)H-N(R10)-C(NR17- N(R10R11, -C(R7)H-N(R1-0)-C(NR17)-R10, -C(NR17)-N(R5R6, -C(R7)H-C(NR17)-N(R5R6-C(R7)N-O-N(R5R6, heterocyclyl [where heterocyclyl radical is not associated with the radical of the formula (i) via a nitrogen atom and optionally substituted by alkyl, aryl, aralkyl, halo, haloalkyl, exography, -OR5, -C(O)OR5, -N(R5R6or-C(O)N(R5R6] or geterotsiklicheskikh [where heterocyclyl radical is not associated with the alkyl moiety through a nitrogen atom and optionally substituted by one or more substituents selected from the group comprising alkyl, aryl, aralkyl, halo, haloalkyl, oxoprop, -OR5, -C(O)OR5, -N(R5R6and-C(O)N(R5R6], or R3denotes a radical of the formula (ii)

where v=1-4;

R13matter listed for formula (i);

R14matter listed for formula (i);

R4in each case independently denotes a hydrogen atom, alkyl, halo, Gal>
R6, R5and R6each independently of one another denotes a hydrogen atom, alkyl, aryl or aralkyl, R7in each case independently denotes a hydrogen atom or alkyl, R8in each case independently denotes a straight or branched alkylenes, alkylidene or alkylidene chain, R9in each case independently denotes an alkyl, aryl or aralkyl, R10and R11each independently of one another denotes a hydrogen atom, alkyl, haloalkyl, aryl, aralkyl, formyl, cyano, -R8-CN, -OR5, -R8-OR5, -S(O)p-R15(where R=0-2), -R8-S(O)p-R15(where R=0-2), -N(R5R6, -R8-N(R5R6, -R8-C(O)OR5, -C(O)-R15, -C(O)NH2, -R8-C(O)NH2, -C(S)NH2, -C(O)-S-R5-C(O)-N(R5R15, -R8-C(O)-N(R5R15, -C(S)-N(R5R15, -R8-N(R5)-C(O)H, -R8-N(R5)-C(O)R15-C(O)O-R8-N(R5R6,- [N(R5R6]=C(R18R10, -R8-N(R5)-P(O)(OR5)2cycloalkyl (optionally substituted by one or more substituents selected from the group comprising alkyl, halo and-OR5), heterocyclyl [optionally substituted by alkyl, Ari is de R=0-2), -R8-S(O)p-R9(where R=0-2), -N(R5R6or-C(O)N(R5R6] or geterotsiklicheskikh [optionally substituted by one or more substituents selected from the group comprising alkyl, aryl, aralkyl, halo, haloalkyl, oxoprop, -OR5, -R8-OR5, -C(O)OR5, -S(O)p-R9(where R=0-2), -R8-S(O)p-R9(where R=0-2), -N(R5R6and-C(O)N(R5R6] or R10and R11together with the nitrogen atom to which they are attached, form a N-heterocyclic ring containing zero to two additional heteroatoms, where N-heterocyclic ring optionally substituted by one or more substituents selected from the group comprising alkyl, halo, haloalkyl, aryl, aralkyl, oxo - nitro-, cyano, -R8-CN, =N(R17), -OR5, -C(O)OR5, -R8-C(O)OR5, -N(R5R6, -R8-N(R5R6-C(O)N(R5R6, -R8-C(O)N(R5R6, -N(R5)-N(R5R6, -C(O)R5, -C(O)-(R8-O)t-R5(where t=1 to 6), -S(O)p-R9(where R=0-2), -R8-S(O)p-R9(where R=0-2), -(R8O)t-R5(where t=1-6) and heterocyclyl [optionally substituted by one or more substituents selected and 5
R6], R12denotes the side chain of-amino acids, R15in each case independently denotes an alkyl, cycloalkyl, haloalkyl, aryl, aralkyl, -R8-O-C(O)-R5, -R8-OR5, -N(R5R6, -R8-N(R5R6, -R8-C(O)OR6, heterocyclyl [optionally substituted by one or more substituents selected from the group comprising alkyl, aryl, aralkyl, halo, haloalkyl, -OR5, -R8-OR5, -C(O)OR5, -N(R5R6and-C(O)N(R5R6] or geterotsiklicheskikh [optionally substituted by one or more substituents selected from the group comprising alkyl, aryl, aralkyl, halo, haloalkyl, -OR5, -R8-OR5, -C(O)OR5, -N(R5R6and-C(O)N(R5R6] or R5and R15together with the nitrogen atom to which they are attached, form a N-heterocyclic ring containing zero to two additional heteroatoms, where N-heterocyclic ring optionally substituted by one or more substituents selected from the group comprising alkyl, aryl, aralkyl, amino, monoalkylamines, dialkylamines, -OR5, -C(O)OR5aminocarbonyl, monoalkylamines and dialkylamines>R6cycloalkyl (optionally substituted by one or more substituents selected from the group comprising alkyl, halo and-OR5), heterocyclyl [optionally substituted by alkyl, aryl, aralkyl, halo, haloalkyl, -OR5, -C(O)OR5, -N(R5R6or-C(O)N(R5R6] or geterotsiklicheskikh [optionally substituted by one or more substituents selected from the group comprising alkyl, aryl, aralkyl, halo, haloalkyl, -OR5-C(O)OR5, -N(R5R6and-C(O)N(R5R6], or both R16together with the nitrogen atom to which they relate (and when there is no substituent R9form an aromatic N-heterocyclic ring containing zero to two additional heteroatoms, where N-heterocyclic ring optionally substituted by one or more substituents selected from the group comprising alkyl, aryl, aralkyl, -OR5, -C(O)OR5, -R8-C(O)OR5, -N(R5R6, -R8-N(R5R6-C(O)R5, -C(O)(R8-O)t-R5(where t=1-6) and -(R8-O)t-R5(where t=1-6), R17in each case independently denotes a hydrogen atom, alkyl, aryl, aralkyl, cyano, -OR5, -R8-OR5, -C(O)ORPodoroga, alkyl, aryl, aralkyl, cyano, -C(O)OR5or NO2and R19in each case denotes cycloalkyl, haloalkyl, -R8-OR5, -R8-N(R5R6, -R8-C(O)OR5, -R8-C(O)N(R5R6, heterocyclyl [optionally substituted by alkyl, aralkyl, halo, haloalkyl, -OR5, -C(O)OR5, -N(R5R6or-C(O)N(R5R6] or geterotsiklicheskikh [optionally substituted by one or more substituents selected from the group comprising alkyl, aryl, aralkyl, halo, haloalkyl, -OR5, -C(O)OR5, -N(R5R6-C(O)N(R5R6],

where "aryl" is called a phenyl or nattily radical, optionally substituted by alkyl, halogen, -OR5(where R5means hydrogen or alkyl); "heterocyclic ring" is called stable 5-6-membered ring radical which consists of carbon atoms and one or two heteroatoms selected from the group comprising nitrogen, oxygen and sulfur, and nitrogen atoms or sulfur in the heterocyclic ring radical may be optionally oxidized to various oxidation States, the nitrogen atom can be optionally and stereoselectivity, and the ring radical may be partially or pelepasan above, except that the heterocyclic ring radical may be linked to the main structure via any heteroatom or carbon atom, resulting in a stable structure, in the form of a single stereoisomer, or mixtures thereof, or its pharmaceutically acceptable salt and a pharmaceutically acceptable excipient.

 

Same patents:

The invention relates to new imidazole-cyclic acetals of the formula I, where R1- optionally substituted 4-pyridyl or optionally substituted 4-pyrimidinyl; R2is phenyl, substituted with halogen; R3is hydrogen; R4refers to a group - L3-R14; R5is hydrogen, alkyl or hydroxyalkyl; or R4and R5when attached to the same carbon atom, may form with the specified carbon atom kernel cycloalkyl or the group C=CH2; R6is hydrogen or alkyl and m=1; L3and R14have the meanings specified in the description, and pharmaceutically acceptable salts and solvate (for example, hydrates), which have inhibitory activity against TNF-alpha, as well as to intermediate compounds, pharmaceutical compositions and method of treatment

The invention relates to new derivatives of 2-aminopyridine F.-ly (1) where denotes unsubstituted or substituted phenyl, pyridyl, thienyl, thiazolyl, hinely, cinoxacin-2-yl or Antonelliana derivatives; D is unsubstituted or substituted phenyl, pyridyl, thienyl, pyrimidyl, indolyl, thiazolyl, imidazolyl, hinely, triazolyl, oxazolyl, isoxazolyl or Antonelliana derivatives, provided that C and D are not simultaneously have the following values: S - phenyl, and D is phenyl, S - phenyl, and D - pyridyl, With - pyridyl and D - phenyl, - pyridyl and D - pyridyl; R1- R4- hydrogen, NO2or NH2

The invention relates to new salts of pyridinium General formula (I) or their pharmaceutically acceptable salts, where R1is-R4- R5or-N(R7)N(R7R9, R4choose from the group of-N(R7R6O-, N(R7R6N(R7), -OR6O-,

-OR SIG6N(R7)-, where R6- alkyl, R5choose from the group of alkyl, aryl, including heteroaryl, -COR7, -SO2R7and-COR10where R7Is H, alkyl or aryl, including heteroaryl, R2Is F, Cl, Br, J, alkyl, aryl, including heteroaryl, formyl, acyl, C(O)NR7R10or C(O)or SIG7, m = 0, 1, or 2, R3selected from the group comprising R7OR7N(R7)(R10) and CH(R7)C(O)R8, R8is R7OR7and NR7R10, R9is hydrogen, alkyl, aryl, including heteroaryl, -C(O)R10, -SO2R10, -C(S)OTHER10, -C(NH)NH(R10), -C(O)OTHER10, R10- H, alkyl, or aryl, including heteroaryl, and in each case, it is not necessarily different from R7X represents an ion halogen provided that 1) when two alkyl groups are the same carbon or nitrogen, they are not necessarily linked together with the formation of a cyclic structure, and (2) nitrogen heteroaryl ring R1

The invention relates to 2-(iminomethyl)aminoaniline derivative of General formula I, And where the aromatic residue of the formula Ia, R1and R2independently H, halogen, HE, linear or branched C1-C6alkyl, linear or branched C1-C6alkoxyl, R3-H, linear or branched C1-C6alkyl, or-COR4where R4-C1-C6alkyl or the residue IC, linear or branched C1-C6the five-membered alkyl or a heterocycle containing 1-4 heteroatoms selected from O, S, N, and in particular: thiophene, furan, pyrrole or thiazole, carbon atoms which is unsubstituted or substituted by one or more groups selected from linear or branched C1-C6of alkyl, C1-C6alkoxyl or halogen; X is-CO-N(R3)-X'-, -NH-CO-X'-, -CH=,-CO -, or a bond, and X' represents -(CH2)n- where n = 0-6; Y means Y'-, -Y'-NH-CO-, -CO-Y', Y'-CO-, -N(R3)-Y'-, -Y,-N(R3)-, Y'-CH2-N(R3)-CO-, -Y'-O-, -Y'-O-Y' - or a bond, and Y' is -(CH2)n- where n = 0-6; Неt-pyrrole, pyrrolidine, furan, thiophene, imidazole, imidazoline, oxazole, isoxazol, oxazoline, isoxazole, thiazole, thiazoline, thiazolidine, thiazolidine, azetidine, piperidine, imidazolidine, they

The invention relates to organic chemistry, namely to new derivatives of benzoperylene

The invention relates to new substituted derivatives of piperidine derivatives, to processes for their preparation, to pharmaceutical compositions and to their use in medical therapy, particularly in treatment of psychotic disorders

The invention relates to new derivatives of 1,3-diaryl-2-pyridin-2-yl-3-(pyridine-2-ylamino)propanol of the formula (I)

where Z denotes-NH-(C1-C16-alkyl)-(C=O)-; -(C=O)-(C1-C16-alkyl)-(C=O)-;

-(C=O)-phenyl-(C=O)-; AND1AND2AND3AND4denote independently of each amino-acid residue, E represents-SO2-R4and-CO-R4; R1- phenyl, thiazolyl, oxazolyl, thienyl, thiophenyl and others, R2- N., HE, CH2HE, OMe; R3Is h, F, methyl, OMe; R4denotes -(C5-C16-alkyl), -(C0-C16-alkylen)-R5, -(C=O)-(C0-C16-alkylen)-R5, -(C=O)-(C0-C16-alkylene)-NH-R5and others, R5denotes-COO-R6, -(C=O)-R6-(C1-C6-alkylen)-R7, phenyl, naphthyl and others, R6denotes H, -(C1-C6) alkyl; R7denotes H, -(C1-C7-cycloalkyl, phenyl, naphthyl and others, l, q, m, n, o, p denote 0 or 1, and l+q+m+n+o+p is greater than or equal to 1, and their pharmaceutically acceptable salts

The invention relates to new derivatives of N, S-substituted N'-1-[(hetero)aryl] -N'-[(hetero)aryl] methylisothiazoline General formula I or their salts with pharmacologically acceptable acids HX in the form of a racemic mixture or in the form of a mixture of stereoisomers, which can be used for the treatment and prevention of diseases associated with dysfunction glutamatergic nanoperiodic

Thrombin inhibitors // 2221808
The invention relates to compounds of formula I, the values of the radicals defined in the claims and their pharmaceutically acceptable salts

The invention relates to 4-hydroxy-3-chinainternational and hydrazides of General formula (I), where a represents a-CH2- or-NH-, a R1, R2, R3and R4such as defined in the claims

The invention relates to new derivatives of 2-aminopyridine F.-ly (1) where denotes unsubstituted or substituted phenyl, pyridyl, thienyl, thiazolyl, hinely, cinoxacin-2-yl or Antonelliana derivatives; D is unsubstituted or substituted phenyl, pyridyl, thienyl, pyrimidyl, indolyl, thiazolyl, imidazolyl, hinely, triazolyl, oxazolyl, isoxazolyl or Antonelliana derivatives, provided that C and D are not simultaneously have the following values: S - phenyl, and D is phenyl, S - phenyl, and D - pyridyl, With - pyridyl and D - phenyl, - pyridyl and D - pyridyl; R1- R4- hydrogen, NO2or NH2

The invention relates to derivatives of cyclic amines and their use as pharmaceuticals, particularly to a compound represented by the General formula (I), its pharmaceutically acceptable acid additive salts or its pharmaceutically acceptable C1-C6alcaldicios salt, R1-phenyl, C3-8-cycloalkyl, aromatic heterocycle with 1-3 heteroatoms selected from O, S, N, or combinations thereof, and these groups may be condensed with benzene ring or an aromatic heterocyclic group with heteroatoms, selected from O, S or N, or combinations thereof, and may also have different substituents

The invention relates to new N-phenylamine and N-pyridylamine derivative of the formula I

< / BR>
in which X denotes O or S;

R1and R2which may be identical or different, denote hydrogen, (C1-C6)alkyl or (C3-C8)cycloalkyl or R1and R2together with the carbon atom to which they are attached, form a (C3-C8)cycloalkyl;

R3means (C6-C12)aryl, optionally substituted by one or more radicals Y, which may be the same or different;

Y represents halogen;

R4and R5represent hydrogen;

Ar denotes one of the following groups or WITH:

< / BR>
T represents hydrogen or (C1-C6)alkyl;

T3and T4which may be identical or different, denote (C1-C6)alkyl, (C1-C6)alkoxy, (C1-C6)allylthiourea;

R6and R7each denotes hydrogen or R6and R7together represent a bond;

Z denotes either (I) the divalent group-CHR9- in which the R11-, in which R10and R11together they form a bond that Z represents the group-CH=CH-, or R10and R11that may be the same or different, have the meanings indicated above for R9or (III) a divalent group-CHR12-CHR13-CH2-, in which R12and R13together they form a bond, Z represents-CH=CH-CH2-, or R12and R13that may be the same or different, have the meanings indicated above for R9,

as well as their additive salts with pharmaceutically acceptable acids or bases, and method of production thereof, pharmaceutical compositions and drug manifesting gipolipedimecescoe and antiatherosclerotic action based on them

The invention relates to derivatives of 2-(arylvinyl)aminoimidazole formula I, where R1denotes a group of formula (A), (B) or (C), a R2, R3, R4, R5, R6and X are such as defined in the claims

The invention relates to inhibitors tyrosinekinase type bis-indolylmaleimide compounds of the formula I

< / BR>
where Z denotes a group of General formula II

< / BR>
where A, B, X, Z, R1-R10have the meanings indicated in the claims, as well as the way they are received and drug based on these compounds
Up!