The method of obtaining an antibacterial agent on the basis of doxycycline |
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IPC classes for russian patent The method of obtaining an antibacterial agent on the basis of doxycycline (RU 2191573):
Solid dosage form of an antimicrobial agent / 2191570
The invention relates to medicine, in particular to pharmaceutical preparations, which represents an antimicrobial agent
 Benzoxazinone or pyridoxine compounds, methods for their preparation, intermediate compounds, pharmaceutical composition having antibacterial activity, methods of treatment of bacterial infections / 2191179
The invention relates to new benzoxazine and piridokshinom compounds of formula I, where part of the Q - condensed phenyl, or condensed pyridyl; Z1is hydrogen, halogen, C1-C6alkyl, phenyl, nitro, sulfonylamino or trifluoromethyl; Z2is hydrogen or halogen; X is hydrogen or oxygen; And - C1-C6-alkyl, C1-C6-alkylaryl or C1-C6-Alkylglucoside, where aryl and heterocyclyl described in the claims, n = 0 to 3; Y is the portion described in the claims, and their pharmaceutically acceptable salts, esters and proletarienne forms
The way to prevent septic complications in the postoperative period / 2191014
The invention relates to medicine, in particular to surgery, and can be used for prophylaxis of septic complications in the postoperative period
 Salt of 5,5'-aileenpearlpiyali and 5,5'-arylidene(2 - thiobarbiturate) acid and 5,5'-arylidene(2 - thiobarbiturate) acid, which has antimicrobial, antiviral, immunomodulatory and antitumor activity / 2188195
The invention relates to new salts of 5,5'-aileenpearlpiyali and 5,5'-arylidene(2-thiobarbiturate) acid and 5,5' - arylidene(2-thiobarbiturate) acids of General formula I having antimicrobial, antiviral, immunomodulatory and antitumor activity
 The method of treatment of experimental leprosy infection / 2188003
The invention relates to medicine, to leprology, can be used to treat leprosy infection in the experiment
 Drug / 2187331
The invention relates to medicine and the pharmaceutical industry and relates to encapsulated or tableted form of pharmaceutical preparations containing recombinant interferon
 7-acetoxy-3-(n-bromophenyl)-aminomethane having antibacterial activity / 2186777
The invention relates to new biologically active compound, namely 7-acetoxy-3-(n-bromophenyl)-aminomethylpropanol formula 1, which has antibacterial activity and can be used in medicine as a drug
 Derivatives of 1-methyl-5-chloropyrazole and method of production thereof / 2186772
The invention relates to new derivatives of 1-methyl-5-chloropyrazole General formula where R is CH2Cl, CF3, 4-CLC6H4, 3-NO2C6H4that shows antibacterial activity
 Preparation of polyvalent bacteriophage against escherichia coli, strains of bacteriophage bacteriophagum pseudomonas aeruginosa state medical academy n.a. i. i. mechnikov no. 05, no. 03, no. 06 and # 07, used in the preparation of polyvalent drug against pseudomonas aeruginosa / 2186574
The invention relates to the field of biotechnology
The way monotherapy pyloric helikobakterioza / 2185827
The invention relates to medicine, in particular to therapy, and is intended for monotherapy pyloric helikobakterioza
Solid pharmaceutical composition for oral administration in the treatment of leishmaniasis and method of its manufacture, pharmaceutical combination for the treatment of leishmaniasis in mammals and treatment (options) / 2190390
The invention relates to medicine, in particular to novel solid pharmaceutical compositions containing hexadecylphosphocholine (miltefosine) for oral administration in the treatment of leishmaniasis, to a method for the production of specified pharmaceutical compositions for the treatment of leishmaniasis specified pharmaceutical composition to a combination that includes the specified solid pharmaceutical composition, an antiemetic and/or antidiarrheal agent
 The method of obtaining medicinal drug holesin / 2189810
The invention relates to medicine, namely to a method for gastrointestinal drug in gelatin capsules
Composition of antibacterial drugs / 2188018
The invention relates to the field of pharmacology, and relates to antibacterial drugs
 Pharmaceutical compositions / 2185188
The invention relates to the preparation, for example, in the form of capsules, soft coated, containing as active ingredient cyclosporine
The pharmaceutical composition of lincomycin / 2183960
The invention relates to medicine, specifically to pharmaceutical compositions comprising as active ingredient an effective amount of lincomycin hydrochloride and targeted supplements, which are used starch and powdered sugar
Pharmaceutical composition having analgesic, anti-inflammatory, antipyretic and antispasmodic effect / 2183116
The invention relates to medicine and medical industry and relates to a pharmaceutical composition having analgesic, anti-inflammatory, antipyretic, antispasmodic effect
Pharmaceutical composition with anti-inflammatory, analgesic and antipyretic action / 2182824
The invention relates to medicine, specifically to a pharmaceutical composition for the treatment of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, acute gout, back pain, neuralgia, myalgia, traumatic inflammation of soft tissues and musculoskeletal system, acute infectious-inflammatory diseases of the upper respiratory tract, dysmenorrhea
 Pharmaceutical composition containing cyclosporin, a method of obtaining soft gelatin capsules / 2178293
The invention relates to pharmacology
The way angiographic contrast lower extremity arteries / 2191038
The invention relates to medicine, namely to vascular surgery, and can be used for angiographic contrast lower extremity arteries
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(57) Abstract: The invention relates to medicine and relates to a method of producing an antibacterial agent, comprising mixing the active ingredients in doxycycline hydrochloride with calcium stearate, lactose, potato starch and filling the mixture gelatin capsules with the mixture of ingredients is preloaded into the mixture with stirring for 3-5 minutes add 5-10% calcium stearate from the calculated amount, the mixture is dried to a residual moisture content of 2.5 to 4.5%, add the remaining amount of calcium stearate obtained dry mixture contribute in gelatin capsules, pre-treated with an inert gas at a feed rate of the gas 3-5 m/s Technical result of the invention consists in expanding the range of products on the basis of doxycycline and simplify the method of obtaining drugs in capsulated form. table 1. The invention relates to medicine and relates to antibacterial agents on the basis of doxycycline, namely, how to obtain it. Doxycycline 6-deoxy-5-oxytetracycline hydrochloride, has antimicrobial activity (Handbook "Drugs" Mashkovsky M. D., M, "Medicine", 1986. , pages 228-229, cha is swesty ways to get antibiotics on the basis of doxycycline for intravenous (RF patents 1585944, 2142804, 2108783). A known method of manufacturing solid dosage forms such as tablets with controlled release of the active substances by mixing doxycycline with the carrier and coating of ethylene vinyl acetate on the tablet. Received the tablets in the coating create mechanical by one or more linear holes (U.S. Pat. RF 2072835). A method of obtaining pharmaceutical drugs in the form of capsules. Capsules are made from various biologically erodible polymers (U.S. patent 4652441). Use the capsule form of the medication allows you to adjust the release rate of drugs, which should be constant throughout the time of selection. The choice of material of the capsule should be optimized for each drug and each scheduled time allocation, and this optimization requires a lot of time and effort. A method of obtaining pharmaceutical compositions of the prolonged action containing a water soluble drug on the basis of doxycycline, dispersed in a biologically erodible polymer polylactic acid. Biopolymer further comprises a copolymer of glycolic acid and hydroxycarbonate colorspace obtain matrix pellets by extrusion of the molten mixture, containing doxycycline and excipients, which can then be milled to obtain a powder and used in this form, for example in solid deletirovannykh capsules. As auxiliary substances used water-soluble polymer, a plasticizer polymer and natural or semi-synthetic polymeric gelling (polysaccharide derived cellulose), calcium stearate, various derivatives of starch, lactose (U.S. Pat. RF 2155031). The disadvantage of this method is the use of a large number of ingredients, and the high cost of energy for the extrusion of the melt, the loss of activity of the medicinal product through the use of high temperatures upon receipt of the melt. The aim of the invention is to widen the range of products on the basis of doxycycline, a simplified method of obtaining drugs in capsulated form. This goal is achieved through the use of the method of manufacturing a pharmaceutical preparation, comprising a mixture of active substances doxycycline hydrochloride with calcium stearate, lactose, filler and filling the mixture gelatin capsules. The filler used kartoffelsalat 5-10% calcium stearate from the calculated amount, the mixture is dried to a residual moisture content of 2.5 to 4.5%. add the remaining amount of calcium stearate. The obtained dry mixture with the ratio of ingredients, wt.%:Doxycycline hydrochloride 30-34 Potato starch - 30-34 Calcium stearate - 0,5-1,5 Lactose - Rest make gelatin capsules, pre-treated with an inert gas at a feed rate of the gas 3-5 m/s It is known that sugars have low formability and high dissolution rate. While at solving the problems we had to achieve a slow release medication directly into the gastrointestinal tract and to develop a recipe that would easily capsulerebel powder in a gelatin capsule. Created recipe with favorable properties for filling capsules by adding calcium stearate portions at a specific humidity and surface treatment capsules in accordance with the present invention. Using the claimed method, get reproducible and adjustable results on drug release doxycycline hydrochloride of the capsules. The amount of ingredients stated in the claims, has been selected the most is orosco with a residual moisture content of 2.5 to 4.5% on the basis of doxycycline, including potato starch, lactose and calcium stearate, does not require molding and well capsulized in a gelatin capsule, processed in accordance with the invention, an inert gas, resulting in slightly dried inner surface of the gelatin capsule, which makes it easy to capsulerebel. No need granulation mixture before kapsulirovaniem simplifies the technology of reception of a preparation and its composition. A mixture of lactose, starch and calcium stearate in the specified proportions upon the submission of calcium stearate in two stages provides good adhesion of the active substance doxycycline with filler. The mixture is well mixed and homogeneous throughout the volume. An example implementation of method 1. In the mixer SGK-200 mix the active substance - doxycycline hydrochloride, potato starch, lactose, taken in the required quantities, add 5-10% calcium stearate from the calculated amount, the mixture is stirred for 3-5 minutes On a shelf drier at 35oThe mixture is dried to a residual moisture content of 2.5 to 4.5%, add the remaining amount of calcium stearate. In kapsulirovaniya machine filled with open desire the ri on the inner surface of the gelatin capsules formed thin film, allows you to easily fill capsules. In the treated capsule serves obtained dry mixture with the ratio of ingredients in accordance with the formula. The results of the experiment are summarized in table. Using the proposed method allowed us to obtain the product is stable when stored at 40oWith in the period of time equivalent to two years of storage at room temperature during one year of storage under natural conditions. A very important advantage of the claimed method is almost constant release rate of the active compounds of the drug for virtually the entire period of time. The rate of dissolution and raspadaemosti meets the requirements of farmkomiteta of the Russian Federation. Gelatin capsule with declared sparing treatment with an inert gas retains elasticity and the desired moisture content of 11-12%. In examples 1-3 the stirring was carried out for 3-5 minutes In example 4, the stirring was carried out for 7 min, it was observed sticking to the walls of the equipment, bad encapsulation mixture, the mixture is heterogeneous in composition. A method of manufacturing a pharmaceutical preparation, comprising a mixture of active substances doxycycline of hydrochl is este filler use potato starch, when mixing ingredients preloaded into the mixture with stirring for 3-5 minutes add 5-10% calcium stearate from the calculated amount, the mixture is dried to a residual moisture content of 2.5 to 4.5%, add the remaining amount of calcium stearate obtained dry mixture with the ratio of ingredients, wt.%: Doxycycline hydrochloride 30-34 Potato starch - 30-34 Calcium stearate - 0,5-1,5 Lactose - Rest make gelatin capsules, pre-treated with an inert gas at a feed rate of the gas 3-5 m/s
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