Solid dosage form of an antimicrobial agent |
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IPC classes for russian patent Solid dosage form of an antimicrobial agent (RU 2191570):
 Benzoxazinone or pyridoxine compounds, methods for their preparation, intermediate compounds, pharmaceutical composition having antibacterial activity, methods of treatment of bacterial infections / 2191179
The invention relates to new benzoxazine and piridokshinom compounds of formula I, where part of the Q - condensed phenyl, or condensed pyridyl; Z1is hydrogen, halogen, C1-C6alkyl, phenyl, nitro, sulfonylamino or trifluoromethyl; Z2is hydrogen or halogen; X is hydrogen or oxygen; And - C1-C6-alkyl, C1-C6-alkylaryl or C1-C6-Alkylglucoside, where aryl and heterocyclyl described in the claims, n = 0 to 3; Y is the portion described in the claims, and their pharmaceutically acceptable salts, esters and proletarienne forms
The way to prevent septic complications in the postoperative period / 2191014
The invention relates to medicine, in particular to surgery, and can be used for prophylaxis of septic complications in the postoperative period
 Salt of 5,5'-aileenpearlpiyali and 5,5'-arylidene(2 - thiobarbiturate) acid and 5,5'-arylidene(2 - thiobarbiturate) acid, which has antimicrobial, antiviral, immunomodulatory and antitumor activity / 2188195
The invention relates to new salts of 5,5'-aileenpearlpiyali and 5,5'-arylidene(2-thiobarbiturate) acid and 5,5' - arylidene(2-thiobarbiturate) acids of General formula I having antimicrobial, antiviral, immunomodulatory and antitumor activity
 The method of treatment of experimental leprosy infection / 2188003
The invention relates to medicine, to leprology, can be used to treat leprosy infection in the experiment
 Drug / 2187331
The invention relates to medicine and the pharmaceutical industry and relates to encapsulated or tableted form of pharmaceutical preparations containing recombinant interferon
 7-acetoxy-3-(n-bromophenyl)-aminomethane having antibacterial activity / 2186777
The invention relates to new biologically active compound, namely 7-acetoxy-3-(n-bromophenyl)-aminomethylpropanol formula 1, which has antibacterial activity and can be used in medicine as a drug
 Derivatives of 1-methyl-5-chloropyrazole and method of production thereof / 2186772
The invention relates to new derivatives of 1-methyl-5-chloropyrazole General formula where R is CH2Cl, CF3, 4-CLC6H4, 3-NO2C6H4that shows antibacterial activity
 Preparation of polyvalent bacteriophage against escherichia coli, strains of bacteriophage bacteriophagum pseudomonas aeruginosa state medical academy n.a. i. i. mechnikov no. 05, no. 03, no. 06 and # 07, used in the preparation of polyvalent drug against pseudomonas aeruginosa / 2186574
The invention relates to the field of biotechnology
The way monotherapy pyloric helikobakterioza / 2185827
The invention relates to medicine, in particular to therapy, and is intended for monotherapy pyloric helikobakterioza
Method for the treatment of angina / 2185174
The invention relates to medicine and for the treatment of angina
 Drug-based pentoxifylline / 2190408
The invention relates to medicine, in particular to the pharmaceutical industry, and for funds on the basis of pentoxifylline, which is a derivative of purine, for oral administration
The method of obtaining antiviral agents / 2190407
The invention relates to pharmacology and can be used as an effective tool against viruses simple or herpes zoster
Pharmaceutical composition having antibacterial action, and how you can get / 2190403
The invention relates to chemical-pharmaceutical industry, namely the creation of a pharmaceutical product having antibacterial action
Pharmaceutical composition containing cardioselektivee beta-blocker, and how you can get / 2190397
The invention relates to medicine, specifically to pharmaceutical compositions with beta-adrenoceptor blocking action in the form of a solid dosage form containing a salt of metoprolol and pharmaceutically acceptable additives target, which are used Aerosil, starch, lactose, polyvinylpyrrolidone, and a salt of stearic acid, and its preparation
The method of producing tablets of rimantadine and tablet obtained in this way / 2190393
The invention relates to the production of tools for the treatment and prevention of influenza in children and adults
 Pharmaceutical composition based on doxazosin / 2190392
The invention relates to medicine, in particular to drugs on the basis of doxazosin with antihypertensive, vasodilator, anti-atherosclerotic effect, is effective in the treatment of benign prostatic hyperplasia in the early stages
Multivitamin preparation with mineral additives and method thereof / 2190391
The invention relates to chemical-pharmaceutical industry, namely the creation of a multivitamin preparation with mineral additives
Solid pharmaceutical composition for oral administration in the treatment of leishmaniasis and method of its manufacture, pharmaceutical combination for the treatment of leishmaniasis in mammals and treatment (options) / 2190390
The invention relates to medicine, in particular to novel solid pharmaceutical compositions containing hexadecylphosphocholine (miltefosine) for oral administration in the treatment of leishmaniasis, to a method for the production of specified pharmaceutical compositions for the treatment of leishmaniasis specified pharmaceutical composition to a combination that includes the specified solid pharmaceutical composition, an antiemetic and/or antidiarrheal agent
Pharmaceutical composition in the form of a soluble effervescent tablets and how you can get / 2189228
The invention relates to chemical-pharmaceutical industry, namely soluble effervescent tablets for oral administration and method of production thereof
Benzoxazinone or pyridoxine compounds, methods for their preparation, intermediate compounds, pharmaceutical composition having antibacterial activity, methods of treatment of bacterial infections / 2191179
The invention relates to new benzoxazine and piridokshinom compounds of formula I, where part of the Q - condensed phenyl, or condensed pyridyl; Z1is hydrogen, halogen, C1-C6alkyl, phenyl, nitro, sulfonylamino or trifluoromethyl; Z2is hydrogen or halogen; X is hydrogen or oxygen; And - C1-C6-alkyl, C1-C6-alkylaryl or C1-C6-Alkylglucoside, where aryl and heterocyclyl described in the claims, n = 0 to 3; Y is the portion described in the claims, and their pharmaceutically acceptable salts, esters and proletarienne forms
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(57) Abstract: The invention relates to medicine, in particular to pharmaceutical preparations, which represents an antimicrobial agent. Solid dosage form of an antimicrobial agent containing as an active ingredient ofloxacin, as well as microcrystalline cellulose, low molecular weight polyvinylpyrrolidone and stearic acid or a salt thereof, further comprises a starch and/or modified starch and/or croscarmellose with appropriate ratio of components. Used in the pharmaceutical composition with the stated ratio of the components ensures optimum physico-chemical and technological properties of the dosage form and high bioavailability of drug substances. 4 C.p. f-crystals. The invention relates to medicine, in particular to pharmaceutical preparations, which represents an antimicrobial agent. One of the known antimicrobial agents is ofloxacin. This drug has been disclosed in Japanese patent application 57046986, IPC 07 D 498/06, a 61 K 31/535, publication 17 March 1982 Currently on the market presents the drug of flocculosa, low molecular weight polyvinylpyrrolidone and magnesium stearinovokisly (VFS 42-3556-99, date of registration 17.02.00). The disadvantage of this dosage form can be seen in the fact that the mass derived from the starting components, for tabletting is not uniform fluidity. Perhaps sticking weight at a press tool and adhesion of its particles with each other. The problem to which the invention is directed, is to obtain solid dosage forms antimicrobial drugs ofloxacin, all relevant pharmacopoeial requirements, qualitative and quantitative composition which will provide high technology in the manufacture of the drug, while ensuring guaranteed raspadaemosti and rapid release of his drugs. The problem is solved due to the fact that the solid dosage form of an antimicrobial agent containing as an active ingredient ofloxacin, as well as microcrystalline cellulose, low molecular weight polyvinylpyrrolidone and stearic acid or its salts, according to the invention further comprises a starch and/or modified starch and/or croscarmellose when following hmal, and/or crosscarmellose - 1-35Microcrystalline cellulose - 5-52 The low-molecular polyvinylpyrrolidone - 1-2 Stearic acid or its salts - 0,3-1,2 Solid dosage form preferably may be in the form of tablets, film coated liner. In accordance with pharmacopoeial requirements solid dosage form must contain 0.2 g of ofloxacin. Selection of components for said solid dosage form was carried out experimentally. It was found that for uniform fluidity tableting mass and, consequently, ensure accurate dispensing of medicinal substances it is advisable to add in a component of starch. Moreover, the amount of starch should be not less than 1 wt.% and not more than 35 wt.%. Having antifrictional properties, starch prevents the accumulation of tableting mass at a press tool and the sticking of its particles with each other. This leads to an increase in the speed tabletting and reduces the wear of the press tool. Starch, introduced in dry form, contributes guaranteed raspadaemosti dosage forms and rapid release of her lekarstvennyy tableting mass and grouting from the dosage form, the consequence would be a reduction in the bioavailability or its complete loss. Moreover, to improve the above positive properties of starch can be partially or completely replaced by a modified starch or croscarmellose. As modified starch is advisable to use sodium carboximetilkrahmal. Solid dosage form of the antimicrobial agent in the form of tablets, film coated liner get the following technological scheme using standard processing operations: preparation of raw materials; hydration weight; wet granulation; drying the wet granulate; dry granulation; the dusting granulate; tableting; preparation of composition for coating; the coating on the pill. As example can be mentioned the following composition per tablet ofloxacin 0.2 g, coated g: Ofloxacin - 0,2 Potato starch, or carboximetilkrahmal, or croscarmellose - 0,025 Microcrystalline cellulose - 0,075 The low-molecular polyvinylpyrrolidone - 0,005 Stearic acid or its salts (MAG is for, or oksipropilmetiltselljuloza - 0,0028 The low-molecular polyvinylpyrrolidone - 0,0028 Titanium dioxide - 0,0007 Tween-80 - 0,0007 Total (whole tablet): - 0,315 Used in the pharmaceutical composition with the stated ratio of the components ensures optimum physico-chemical and technological properties of the dosage form and high bioavailability of the drug. Received antibacterial broad-spectrum action used in bacterial infections: infections of the lower respiratory tract, the ear, throat, nose, skin, soft tissues, bones, joints, infectious-inflammatory diseases of abdominal cavity organs (with the exception of bacterial enteritis) and pelvis; infections of the kidneys and urinary tract, prostate, gonorrhea is caused by sensitive to the medication microorganisms. 1. Solid dosage form of an antimicrobial agent containing as an active ingredient ofloxacin, as well as microcrystalline cellulose, low molecular weight polyvinylpyrrolidone and stearic acid or its salts, characterized in that it further comprises a starch and/or modified starch and/or croscarmellose p is consistent starch, and/or crosscarmellose - 1-35 Microcrystalline cellulose - 5-52 The low-molecular polyvinylpyrrolidone - 1-2 Stearic acid or its salts - 0,3-1,2 2. Solid dosage form under item 1, characterized in that the modified starch is used carboximetilkrahmal. 3. Solid dosage form under item 1 or 2, characterized in that it is made in the form of tablets. 4. Solid dosage form under item 3, characterized in that the tablet is covered with a film cover. 5. Solid dosage form according to PP.1-4, characterized in that it contains 0.2 g of ofloxacin.
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