A method of increasing immune resistance

 

(57) Abstract:

The invention relates to medicine, in particular to immunology, and related to the increased resistance of the organism. To do this, enter once a day intramuscularly citropram-With 0.25% solution of 4 ml, inside Riboflavin 0.005 g, nicotinamide 0,015 grams twice per day orally 0.1 g of tocopherol acetate. The method provides immunological resistance by increasing the phagocytic activity of the cells.

The invention relates to medicine, in particular to urology. The prototype of the invention is to increase immune resistance by assigning thymogen (Pashina T. G., Gray, S. C. Effect of thymus on the expression of differentiation antigens of lymphocytes. In Proc. of Biochemistry in medicine". - L. , 1988, p. 155-156). The disadvantage of the prototype is that timogen, stimulating T-immunity does not affect the phagocytic activity.

The purpose of the invention is the improvement in the immune resistance by increasing phagocytic activity.

The invention consists in the details of cytochrome-From 0.25% to 4.0 ml once a day, tocopherol acetate 0.1 g two times a day, nicotinamide 0.015 g once a day, Riboflavin 0.005 g one AET reduced immune resistance. Along with humoral immunity is suppressed phagocytic activity. The latter depends on the supply ATP acid formed in the process of biological oxidation.

Pharmacological analogues of coenzymes biological oxidation (Riboflavin, nicotinamide, tocopherol acetate, cytochrome-C) increase the intensity of the processes of biological oxidation, thus increasing the phagocytic activity.

The above situation is confirmed by the following example. An experiment was conducted on 15 Wistar rats wiring kennel "Rapolano". The first group (5 animals) was infected retroorbital virulent strain 9198 "Staphilococcus aureus in sublethal dose, the second group (5 animals) was infected with the same microbe in the same dose and received daily inside tocopherol acetate 0,01, Riboflavin nucleotide 0.0005 g, nicotinamide 0.0015 g, were injected intraperitoneally cytochrome-With 0.25% solution of 0.4 ml of the Third group (5 animals) were subjected to therapeutic effects of the above drugs in the same doses. 11-e day after infection and the start of treatment:

indicators of lysosomal cationic test was in the 1st group 1,010,031, in the 2nd 1,450,058; 3rd 1,450,011 (when comparing groups in which all cases of p<0,05);

The method of increasing the immune resistance of the organism, characterized in that it is used once a day intramuscularly cytochrome - With 0.25% solution to 4 ml, the inside of Riboflavin 0.005 g, nicotinamide 0,015 grams twice per day orally - tocopherol acetate 0.1,

 

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