Cartridge for nicotine inhaler and method of its manufacture

IPC classes for russian patent Cartridge for nicotine inhaler and method of its manufacture (RU 2067876):

A61M15/06 - Inhaling appliances shaped like cigars, cigarettes or pipes

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(57) Abstract:

The invention relates to the field of medical technology. The inventive cartridge for nicotine inhaler includes a housing 10 in which is placed a reservoir 16 with nicotine, sealed from the outer environment through impermeable to nicotine septum 18. The cartridge 10 is connected to the mouthpiece 22 with the mouthpiece 24. The invention includes a method of manufacturing a cartridge. 2 C. and 13 C.p. f-crystals, 7 Il.

The present invention relates to medicine and medical technology and is used as a tool to help you stop Smoking.

Due to the attractive nature of nicotine acceptable alternative to Smoking is the consumption of nicotine in a form or manner other than Smoking.

Known smokeless cigarette that allows you to inhale nicotine through an elongated tube in which is inserted a reservoir of porous polymer containing svobodnovihrevye basis. Caused by inhaling the air flow carries a pair of nicotine into the lungs of the user, to satisfy the cravings to smoke.

The invention is illustrated in the drawing:
Fig. 1 is a view in section of a cartridge according to the invention, in which the tank with nicotine;
f is amnike of the mouthpiece of Fig.2. Fig.3A shows Chuck, ready to put the piercing of the foil at one end of the cartridge, and Fig.3B shows Chuck, fully entered into the mouthpiece;
Fig. 4 perspective view of the cassette with a sharp edge for the cartridge and mouthpiece in Fig.1-3;
Fig.5-a-view in section, showing the cartridge of Fig.1, being introduced in the mouthpiece and the face, punched outer end tip of the mouthpiece;
Fig.6 perspective view of the variant according to Fig.5; and Fig.7.

Fig.7 perspective view of the cassette for the variant of the invention shown in Fig.5 and 6.

Further exemplary embodiments of the invention will be described in detail (see pictures), Fig.1 shows a cartridge 10 according to the invention, made in the form of a cylindrical housing 12 that defines a channel 14 through which may pass the stream, for example, air. Inside the channel 14 is a tank 16 containing svobodnovihrevye basis (reasons below). The reservoir 16 may be made in the form of a tube of porous polymer, or other suitable materials. The tank is made of porous polyethylene, in which is placed a thin layer of liquid nicotine. A plastic tube can be filled with a mixture of nicotine, menthol and ethanol. Sootnosheniyu and showed good results. For example, the composition of this solution for approximately 150,000 polyethylene tubes includes 18,000 grams of ethanol, 15 000 grams of nicotine and 150 menthol. The required amount of ethanol is put into a mixer (not shown), then there is added menthol, which is stirred until complete dissolution.

Then solution is added to the nicotine, which is stirred by hand for about 3 minutes.

Then the mixing tank is closed tightly fitted lid. The temperature of the cooling water in the cooler (not shown) is installed on the 14^oC; water circulates at a rate of 10 liters per minute. In a vacuum drier with sheath (not shown) with an internal volume of 260 liters water circulates through the shell at a speed of 5 liters per minute, the temperature 20-1^oC. the Tubes are placed in a vacuum drier and in the vessel, a vacuum of less than 27 inches of mercury.

Nicotine-ethanol solution retracts under the action of vacuum in the vacuum drier. Then, the vacuum valve is closed. The vacuum must not exceed 20 inches of mercury. Then vacuum drier rotates at a speed of 4 revolutions per minute for 10 minutes. Then turn on the vacuum pump, O. goodny drier and the pump should work as long as the temperature difference between the temperature inside the vacuum drier and the temperature of the water supplied to the desiccant reaches 5-6^o. In the above process was applied deep-vacuum pump Kinney, model KS-8.

For achieving the above-mentioned temperature difference, a vacuum drier and the pumps shut down. Then the vacuum drier is filled with nitrogen, and the polyethylene tubes are unloaded in a container of special design, sparse to a pressure of 28 inches of mercury and then filled with nitrogen. This process is then repeated until a complete removal of oxygen from the system. Nitrogen-filled plastic tube is then inserted into the corresponding tube in a nitrogen atmosphere and sealed following way.

To prevent penetration of oxygen into the cartridge 10 after manufacture, and to prevent the escape of nicotine from the cartridge 10, the cylindrical body 12 is made from nicotinecontaining material. Suitable material is a copolymer of Acrylonitrile and methacrylate, implemented under the trade name Barex company C. R. - Sohio.

MNC, that crystalline polymers having a small intermediate space, are more suitable for this purpose. However, it was found that such compounds are ineffective as regards the prevention of the escape of nicotine. All of a sudden, Barex demonstrated the greatest efficiency, although it is an amorphous polymer.

Barex is suitable for this application material in particular because he is able to fasten in a hot forming nicotinereplacement the jumper in place attachment and consists of ingredients permitted for use as adhesives position 21CFR175.105 administration products and medicines. Barex may also be made of aluminum or other metal foil so that the corresponding nicotinereplacement the packaging can be easily manufactured by mounting in a heated form adjacent layers of film Baracca with aluminum foil as the basis for one or more layers.

In the device according to Fig.1. to save the inert gas in the tube after entering the reservoir 16 both ends of the tube are closed nicotinereplacement jumper, for example, a layer of aluminum foil 18. Layers fogi could be easily attached to the ends of the tube 12 from Baracca by heating. At a time when Barex can be attached to the aluminum foil by using the appropriate adhesive, such adhesive may not be used for fastening layers of Barecca to each other or aluminum foil to Baraka, because such adhesives are not nicotinereplacement, and nicotine can escape through the site of fortifications.

The cartridge 10 of the above type can be used in combination with the mouthpiece 22, as shown in Fig.2. By making the cylindrical housing 12 from Baracca and use pieces covered with Barexam aluminum foil for the manufacture of sections of the channel jumpers svobodnovihrevye base, placed in the reservoir 16, is protected from volatilization of the cartridge 10, if nikotinsoderzhaschie tank 16 is introduced and stored in Beskaragai environment. For example, by filling the cartridge 10 with an inert gas, such as nitrogen, to prevent the deterioration of qualities svobodolyubivoi basis due to the interaction with oxygen. Thus, breaking the foil 18 the following way, the consumer will receive an effective dose of nicotine.

Alternatively, the above-described construction nicotinergic is whether other hard materials by applying a layer of Baracca on the inner surface of the tube. Instead of the tube can be used in the tank, which can be produced with the outputs at each end and be completely covered with a layer of Baracca with the condition that its ends can be broken, as already mentioned. According to the invention can be made and other suitable capsules, provided that nicotine is isolated from the atmosphere using nicotinereplacement jumpers this jumper can be broken to release the nicotine, when you need it.

As shown in Fig.2, can be applied to the mouthpiece 22, including the mouthpiece 24 and capsulerebel 26. The channel 28 is for sugunya 24 to parenterally 26.

As shown in Fig.3A and 3B, in order to lay the cartridge 10 in the mouthpiece 22, the cartridge 10 is set in the outer end of capsulorraphy 26 near the pointed tip 30, which is designed around a part of the channel 28 that is associated with parenterale 26. Pointed tip 30 has the shape of a cylinder, truncated at an angle, so that between the outer surface of the pointed tip and the inner surface of parenterally 26 formed cylindrical space 32 for the reception of a cylindrical housing 12, when the capsule 10 is supplied to the place, parvataneni so, when the cartridge 10 is in the position shown in Fig.3B, the cartridge 10 is held in place by a cylindrical wall which forms parenterally 26. Upon submission of the capsule in the direction of the arrow 34 a pointed tip 30 penetrates the layer 18 of aluminum foil on the inner end of the cartridge 10 and opens it in the channel 28 of the mouthpiece 22.

In order to ensure the passage of air through the cartridge 10 and around or through the tank 16, nicotinereplacement layer 18 on the outer end of the cartridge 10 must also be broken. This operation can be performed with a sharp object such as a knife. However, one of the ways to get affordable used sharp object is the manufacture of the cassette 36 of this type, which is shown in Fig.4, and which is manufactured from plastic by extrusion and includes multiple cells 38 for cartridges 10 (not shown) and a recess 40 for the mouthpiece 22. All of these components can be wrapped in clear plastic and used as ready-to-sell packaging.

To get a nice sharp object to puncture foil layers 18 on the outer end of the cartridge 10, at one end of the recess 40 to the mouthpiece 22 may be tapered tip 42. In this slurry end can be punched simple feeding it to a pointed tip 42, as shown in Fig.4. Thus, the channel 28 communicates with the atmosphere through the channel 14 of the cartridge 10, after which the user can inhale through the mouthpiece 24 of the mouthpiece 22 to get a dose of nicotine vapor, as previously described.

As an alternative to using a pointed tip for piercing one or both ends closed by a foil, the foil may be areas that can be crushed (not shown), after which the consumer removes the foil layer 18 of the cartridge 10.

Another variant of the invention shown in Fig.5 and 6, where the cartridge 10 of the above configuration is used in conjunction with punch /cover 44 of the cartridge. As shown in Fig.5A, punch /coating 44 is slipped over the outer end of the cartridge 10 and this combination is then inserted in the outer end of parenterally 26 of the mouthpiece 22, similar to those shown in Fig.2 and 3.

Punch /coating cartridge consists of a cylinder 46, which defines a channel 48, the outer end of which is cylindrical, pointed tip 50, similar in construction to see the detailed tip 30 and parenterally 26. Between the outer surface of the pointed tip 50 and the inner surface of cylinderlike /coating 44 on top of the outer end face of the cartridge 10, he served in the position shown in Fig. 5 in the direction of the arrow 54 (Fig.5B), so that the sharp tip 50 pierces the foil layer 18 located over the outer end of the capsule 10. Thus, the channels 28 of the mouthpiece 22 and 14 of the cartridge 10 are connected to each other and with the atmosphere so that the consumer gets the opportunity to inhale through the mouthpiece and to get a dose of nicotine vapor as previously described.

A variant of the invention shown in Fig.5 and 6, can be Packed, as shown in Fig.7, where the plastic form 56 includes multiple cells 58, designed to accommodate cartridges and punches (coating 44 of the cartridge in the off position, shown in Fig.5A) Cell 60 may be used for placement of the mouthpiece 22, and all items packaged in a transparent plastic (not shown). 2

1. Cartridge for nicotine inhaler, comprising a housing in which the channel and the reservoir with nicotine, placed in the channel and containing a measured amount of nicotine in this form, to secure the release of nicotine vapor to the flow of the fluid passing around or through the tank, and the specified channel has at least two holes, communicating with the external environment to undergo TDI by not permeable to nicotine partitions, which contains jumpers in the channel to seal it on both sides of the tank, and the jumper is made with the possibility of entering the open channel in the outer environment.

2. Chuck under item 1, characterized in that the casing is made in the form of an elongated element, the channel is limited by the inner surface of this member and the opening of the channel are on opposite ends of this element.

3. Chuck under item 1 or 2, characterized in that the elongated element has a cylindrical shape.

4. The cartridge according to any one of paragraphs. 1 to 3, characterized in that the reservoir contains nicotine tube made of porous polymer, charged nicotine free base.

5. Chuck under item 4, wherein the porous tube is made of polyethylene.

6. Cartridge for PP. 1 to 5, characterized in that it is not permeable to nicotine partition contains material of a copolymer of Acrylonitrile and methyl acrylate, forming the body.

7. Cartridge for PP. 1 to 6, characterized in that it is not permeable to nicotine partition contains lots of aluminum foil, forming a jumper in the channel.

8. Chuck under item 7, characterized in that the aluminum foil contains coating mensualidades fact, that is not permeable to nicotine partition contains the body covering of a cartridge in the form of a layer of aluminum foil.

10. Chuck under item 9, characterized in that the aluminum foil contains a coating at least on one side, of a copolymer of Acrylonitrile and methyl acrylate.

11. Chuck under item 10, characterized in that the section of channel between the ridges filled with an inert gas such as nitrogen.

13. Chuck under item 2, characterized in that it is provided with a mouthpiece that contains a long section with the channel having openings at both of its ends, with one end section adapted for positioning in the mouth of a user, and the other end section includes a sleeve with an inner surface configured to hold the body of the cartridge in the channel of the sleeve and the other end of the mouthpiece provided with sharpened on the periphery of the end for punching the appropriate jumpers.

14. A method of manufacturing a cartridge of nicotine inhaler, comprising a stage of forming a housing with a through channel, the charging of the reservoir measured by the amount of nicotine, the introduction of a charged nicotine reservoir in the Chuck body and sealing, characterized in that the housing formerely conditions, which support before and during the introduction of the tank in the Chuck body, and the sealing is realized by means of sealing a charged reservoir in the channel using not permeable to nicotine partitions, including a jumper to seal the channel from both sides of the tank, and a partition in terms of jumpers perform with the possibility of entering the open channel in the outer environment.

15. The method according to p. 14, characterized in that subject to charging tanks placed in a vacuumized chamber, creating in the chamber negative pressure and is injected into the chamber a solution of nicotine, menthol and alcohol, and then remove the charged tanks from the camera in anoxic conditions.