Imaging system for combined full-colour reflectance and near-infrared imaging. RU patent 2510235.

FIELD: physics, optics.

SUBSTANCE: invention provides an imaging system for obtaining an image in the visible and infrared ranges. The method involves continuously illuminating an area under observation with blue/green light, as well as with red light and near-infrared (NIR) light; during illumination, the red light and/or NIR light are switched on and off periodically; directing blue and green reflected light and combined red reflected light and luminescent radiation to image signal generators; the signal generators are capable of separately measuring blue reflected light, green reflected light and combined red reflected light and luminescent NIR radiation; periodically switching on and off the red light and/or NIR light synchronously to obtain a red colour image and a NIR image; separately determining the spectral component of the red reflected light and the spectral component of the luminescent NIR radiation based on the image signals of the combined red reflected light and luminescent NIR radiation; outputting on a screen a full-colour image of the area under observation from the blue and green reflected light and the separately determined red light spectral component, and displaying a NIR image from the luminescent NIR radiation spectral component. The system includes a light source, a video camera with signal generators, a controller and a display.

EFFECT: use of the invention improves resolution of the obtained image in the visible and infrared ranges and reduces the number of artefacts caused by movement.

25 cl, 6 dwg

The technical field to which the invention relates

The present invention relates to the production of images for medical purposes and, in particular, to the system and method of obtaining images of the observed area, such as living tissue, in the visible spectrum, and in the near infrared spectral region, and, in particular, for use in endoscopy.

The level of technology

The literature describes the images in the near infrared range (NIR) for various clinical applications. Usually this method of obtaining images of the contrast agent is used (for example, indocyanine green), which absorb near-infrared radiation and/or fluorescent in this area. Such a contrast agent may be associated with a target molecules (e.g. antibodies) for detection of diseases. Contrast medium may be injected into tissue intravenously or subcutaneously to visualize the structure and function of tissues (for example, flow of blood/lymph/bile in the blood vessels)that it is not easy to see using standard imaging technologies in visible light.

Regardless of the clinical application in endoscopic devices imaging in the near IR region of the spectrum is typically used in practice several modes of image acquisition. For example, endoscopists use the color of the visible spectrum, and for visualization, navigation and endoscopic visualization device that produces an image in the near IR region of the spectrum, usually creates a color image. Such devices with simultaneous images can be, for example, are implemented as follows:

- In one of the traditional configurations used spectral separation of visible light and near infrared radiation so that the signals of full-color images and image signals in the near IR region of the spectrum is obtained using individual sensors for the spectral bands of different colors (e.g. red, green, and blue) and near IR spectral range, or using a single color imager with integrated optical filter with filter elements are transparent to light different spectral bands (for example, red, green, blue and near-infrared region). Thus, these devices produce images with multiple modes to obtain color images and images in the near IR region of the spectrum have a dedicated sensors or sensor pixels for each of the two modes of image acquisition. Unfortunately, this leads to an increase the number of sensors to receive signals image in variants with a large number of sensors or to deterioration of the resolution, when in the same imager some sensors pixels allocated to obtain images in the near IR region of the spectrum, while others are used to obtain color image.

In other traditional configuration uses a single monochrome imager for serial obtain images in the visible and near infrared spectral regions. The object in this case, consistently irradiated with red, green, and blue light the light in the near infrared region of the spectrum, receive individual frames of an image in each region of the spectrum and then generate complex color image and the image in the near IR region of the spectrum based on the obtained image frames. However, this approach when the image frames receive consistently in different moments of time, can produce undesirable artifacts caused by traffic (i.e. color fringing and "effects of the rainbow") in full color image, and the image in the near IR region of the spectrum. These artifacts can "mute" by increasing the frequency of obtaining or image frame rate up to the level above, for example, 15 frames/second (fps (fps)), for example, up to 90 or even up to 180 C/S. Because of the high data transfer speeds of high framerate difficult to implement for images of high definition (for example, 2 million pixels) or image with a wide dynamic range (>10 bits), which limits the size and/or image resolution.

Therefore, it would be desirable to create a way and the system simultaneously for full-color images and images in the near IR region of the spectrum that allows to eliminate the above-mentioned disadvantages, without prejudice to the resolution of the image and/or without the introduction of unwanted artifacts caused by movement.

Disclosure of the invention

According to one aspect of the present invention is a method of obtaining images in the near IR region of the spectrum and full-color images includes coverage of the observed area continuous blue/green light and lighting of this observed area is red and light near The infrared spectral region, and a red light and/or light near IR region of the spectrum periodically turns on and off. Blue, green, red light and light near IR spectral range, returning from the observed field, send to one or more CMOS imagers, made with the possibility of separately measured blue light, green light and a total red light/light near IR region of the spectrum. Spectral component of red light and spectral component of light near IR region of the spectrum determined separately on the basis of the signals image for a total of red light/light near IR region of the spectrum synchronously switching red light and light near IR region of the spectrum. Form-based blue, green and red light full color image of the observed area in the reflected light and display, and the image in the near IR region of the spectrum is similar form on the basis of light near IR region of the spectrum and display.

According to another aspect the present invention visualization system for imaging in the near IR region of the spectrum and full-color image includes the light source for the direction of the visible light and light near IR region of the spectrum to the target area, the camcorder with one or more shapers image signals, made with the possibility of reception separately blue and green light and a total of red light and light near IR spectral range, returning from a certain area, and a controller that communicates with a light source and a video camera. The controller is made with the ability to control light source for continuous lighting fabrics in blue/green light for illumination of observed area is red and light near IR spectral region, and a red light and/or light near IR region of the spectrum periodically turns on and off simultaneously with the receipt red images and images in the near IR spectral range of the camera.

The controller is additionally completed with the ability to determine on the basis of sensor signals representing the total red light and light near IR region of the spectrum, individually spectral component of red light and spectral component of the light in the near infrared region of the spectrum. Visualization system also includes a display, receiving signals image corresponding to blue light, green light and a certain separately spectral component of red light and forming on their basis of full-color image of the observed area. The display also takes a certain separately spectral component of light near IR region of the spectrum and forms based on it the image of the observed area in the near IR region of the spectrum.

Visualization system can use a color video camera with three imager, made with the possibility of continuous imaging in blue and green areas of the spectrum and from time to time image acquisition in the red region of the spectrum to provide a continuous high-quality information on the brightness and sufficiently continuous information on color to build high-quality video images of the observed area, such as living tissue. In this design the shape of red signals the image may use the principle of temporary compaction for red images and images in the near IR region of the spectrum (i.e. the driver of the red images in turn and in rapid succession receives a red light to provide color information, necessary for formation of a color image, and the light in the near infrared region of the spectrum required for the formation of the image in the near IR region the spectrum). This temporary seal can be connected and synchronized with the operation of the light source used for irradiation of light near IR region of the spectrum (excitation of luminescence) and for the irradiation of red light to get to the color image. Then apply image processing to properly divide and process the received signals image.

Variants of the present invention may include one or more of the following symptoms. The observed area can turn to light red light and light near IR region of the spectrum, and the duration of illumination red light may be different, preferably in the direction of increasing, the duration of illumination light near IR region of the spectrum. The mode of lighting can be switched with a frequency fields or frames.

In one variation of the light source can include the illuminator emits essentially constant intensity visible light and light near IR region of the spectrum in the continuous spectrum range, and more moving filters, disposable between the illuminator and the observed area for supplying continuous in time blue/green light and discontinuous in time of red light and light near IR region of the spectrum.

Alternatively, the light source can include the illuminator emits essentially constant intensity visible light and light near IRthe area of continuous spectrum in the spectral range, the first dichroic a means to divide visible light and light near IR region of the spectrum on the blue/green light from one side and the red light and the light near IR region of the spectrum on the other hand, the circuit breaker to convert the selected red light and light near IR region of the spectrum in discontinuous in time red light and discontinuous in time the light near IR region of the spectrum, and the second dichroic tool for summarizing blue/green light with discontinuous in time red light and discontinuous in time the light near IRspectral range, for transmission to the observed area.

In another variant, the light source can include the first light radiant green, and blue light at a constant rate, the second light, generating switchable red light, the third illuminator, generating switchable light excitation in the near IR region of the spectrum, and dichroic tool for summarizing switchable red light and switched the light excitation in the near IR spectral range with green and blue light to transmit to the observed area. Switchable red light and light near IR region of the spectrum can be obtained by interrupting the light beam continuous intensity by blind or breaker. Alternatively, switchable red light and light near IR region of the spectrum can be obtained by means of electric power on and off the second illuminator and third illuminator.

The imager can use interlaced or progressive scan.

Visualization system can be an endoscope.

Brief description of drawings

The following drawings are a number of illustrative options of the present invention, which should be considered only as illustrations, but in no way limits to the present invention.

Figure 1 shows endoscopic visualization system according to one of the variants of the present invention;

figa-2d shows various examples of light source with multiple modes to use in endoscopic system, depicted in figure 1;

figa shows an example of the dichroic prism used in a color video camera with three the imager;

fig.3b shows the ranges of optical transparency for spectral components, separated dichroic prism depicted on figa;

figs shows the range of optical transparency notch filter, no light excitation in video camera;

figure 4 shows a timing diagram of the first option for continuous light blue/green and alternating light red light/light near IR region of the spectrum;

Figure 5 shows a timing diagram second option for continuous light blue/green and alternating light red light/light near IR region of the spectrum;

Fig.6 shows a timing diagram of a third option for continuous light blue/green/light near IRspectral range and alternating light red light; and

Fig.7 shows an example of a CMOS imager is located one above the other layers to get the image and the corresponding spectral sensitivity of these layers.

The implementation of the invention

Color video images are usually obtained with the use of color cameras with three imager, where individual imager for red, green and blue generate simultaneous related information array of red, green and blue pixels. Full-color image is obtained by adding the data in the image from all three imager. Accurate color reproduction (i.e. true color) is extremely important for visualization in medicine, so to get the full color information using all three of the shaper.

However, to understand the relative importance of color and spatial information in the video image of human tissues is useful to consider the information in these videos in terms of brightness and color. The term "brightness" refers to information the brightness of the image, and this is the information that passes spatial detail, allowing the viewer to recognize the shape. Therefore, the spatial and temporal resolution brightness is of fundamental importance for the perception of the quality of the video image. The term "color" refers to the color information in the video image. The peculiarity of human vision is that thin detailed variations of color image elements not easily perceived and therefore are less critical for the overall assessment of image quality than thin detailed variations in brightness. For this reason, the color coding is often done with a low sampling rate.

In the video images of human tissues obtained in visible light, details of fabric structures are concentrated mainly in the fields of blue and green wavelengths. Blue and green light tends to bounce off the surface of the fabric, while the red light has a tendency to strong scattering inside the tissue. As a consequence, very few subtle details patterns in red light rays reaching imager red. From the science of color it is also known that the human vision makes most of spatial information from the green portion of the visible spectrum - that is, the contribution of information green light disproportionate brightness. The standard formula calculation, the brightness on the basis of the color components after the gamma correction looks like Y'=0,2126 R'+0,7152 G'+0,0722 In'. For this reason, spatial and/or temporal interpolation red component video images of human tissues have no significant impact on the perception of the subtle details of these images.

Similarly red light radiation near IR spectral region also has a tendency to scattering in the tissues, resulting in the elements of the images in the near IR region of the spectrum that are blurred, and not sharp. Moreover, because the image in the near IR region of the spectrum allocates interest area (i.e. the area where the localized contrast agent), but does not provide total visual or navigational information, it is desirable that endoscopic visualization device that uses near-infrared region of the spectrum, represented a continuous color image and imposed or on it, or located side by side with him displaying information in the near IR region of the spectrum. The display radiation near IR region of the spectrum will make a smaller contribution to the spatial information is presented to the observer.

1 schematically shows an example of option endoscopic system 10 visualization in the near IR region of the spectrum, including 11 source of light with multiple modes of operation, creating a light in the visible spectrum, and in the near IR region of the spectrum and coupled with an endoscope through 12 lighting fiber, such as fiberoptical cable 17, suitable for transmission colored lighting and lighting light near IR region of the spectrum, a color video camera 13, shown here as having three different shaper 34, 36, 38 image signals (see FIGU) for blue, green and red/middle infrared images respectively and established on the fiber image of the endoscope, and the controller 14 video camera connected to a video camera 13 and 11 source of light for control and synchronization of lighting and image acquisition. The controller 14 can also process the received images in the visible spectrum, and in the near IR region of the spectrum to display on the monitor 15, attached to the controller 14 through, for example, cable 19. You can get images in real time with selectable frame rates, such as the video frame rate.

Figa-2d schematically show examples of various types of sources 11 light. Shows the sources of light are designed to create in normal mode for color images of visible light essentially continuous spectral distribution. A light source may be an arc discharge lamp, halogen lamp, one or more solid-state light sources (for example, LED, semiconductor lasers) or any combination of them and can use spectral filtering or formation of the spectrum (for example, with a band pass filter, infrared filters etc). Continuous spectrum can be obtained by radiation of the primary colors (red, green, and blue (RGB)) simultaneously or consecutively, for example, using a rotating disk with filters.

Shown figa one option source 11a includes light illuminator 202, emitting visible light and light near IR region of the spectrum, collimating lens 204, and also a CD with filters or reciprocating movement of the holder 208 filters, in turn transmits the red light or lights near IR region of the spectrum and continuously transmitting green and blue light. Alternatively, you can use electro-optical or acousto-optic filter. Lens 206 focuses filtered light on the light guide 17.

Another option source 11b light schematically depicted in fig.2b. This source 11b includes light illuminator 202, emitting visible light and light near IR spectral region, and a collimating lens 204. Dichroic mirror 212 passes green/blue light and reflect red light/light near IR region of the spectrum to another dichroic mirror 214, which passes light near IR region of the spectrum to the mirror 215 for light near IR region of the spectrum and reflects a red light or Vice versa. Green/blue light can then be passed through a band-pass filter 213. The reflected red light and light near IR region of the spectrum break through, for example, disk breakers a, 219b (which may be in the form of one disc breaker) to obtain discontinuous in time of luminous flux, which then reflect mirrors 216, 217 and unite with green/blue light by a dichroic mirror 218. United luminous flux next focus through the lens 206 on the fiber 17, as before.

In other variant source 11 light, schematically shown in figs, the illuminator a generates radiation green and blue light, Kallimarmaro through a collimator lens a. Similarly, private lightboxes 202b, s generate respectively radiation red light and light near IR region of the spectrum, Kallimarmaro through relevant collimating lenses 204b and s. As with option to fig.2b, red light and light near IR region of the spectrum interrupt through, for example, disk breakers a, 219b (which may be in the form of one disc breaker) for discontinuous in time the light stream, which is then combined with green/blue light through dichroic mirrors 222, 228. United luminous flux next focus through the lens 206 on the fiber 17, as before.

In another version of the source 11d light, schematically shown in fig.2d, the illuminator a generates radiation green and blue light, Kallimarmaro through a collimator lens a as before. However, unlike options, shown in figs, private lightboxes 202d, 202e here switch electrically to produce radiation red light and light near IR spectral region with managed temporal characteristics. For example, sources 202d, 202e red light and light near IR region of the spectrum can be solid-state light sources, such as the LEDs or semiconductor lasers that can be quickly turned on and off by means of appropriate, preferably electronic keys. As described above in relation to figs, red radiation and radiation near IR region of the spectrum colliery through relevant collimating lenses 204b and s and then unite with green/blue light through dichroic mirrors 222, 228. United luminous flux next focus through the lens 206 on the fiber 17, as before.

Alternating light red light and light near IR region of the spectrum synchronize with the obtaining of an image by the camera with three imager, so the camera gets a red image and the near IR region of the spectrum synchronously with the lighting of a red light and light near IR region of the spectrum in the endoscope.

On figa more detail camcorder 13 with three imager presented in figure 1, in particularly here used optical beam splitter for direction red/near-infrared, green and blue light at three different shaper 34, 36 and 38, respectively, image signals. For applications with luminescence in the rays of the near IR region of the spectrum camcorder preferably also includes filter 32 to block a range of excitation wavelengths. The beam splitter can be done, for example, several dichroic prism cubic beam splitters, plate beam splitters or film beam splitters. On fig.3b shows the spectral composition of light coming from the endoscope according figa. On figs shows the spectral composition of light, seen through the filter 32 to block a range of excitation wavelengths, implemented in the form of a notch filter 31, blocking the passage of radiation excitation, but transmissive with other wavelengths in visible and near-IR spectral range. Characteristics of the transmission of this filter, 32 can be designed in such a way as to block unwanted components in the near IR region of the spectrum that can interfere with the radiation of the visible spectrum, which may cause degradation of the color image.

Figure 4 shows a timing diagram example of the first option is implemented with the simultaneous receipt and submission of a color image and the image in the near IR region of the spectrum, using, for example, camcorder with three imager. In this variant, the imager in the composition of the camcorder using the format receive interlaced, which is the preferred combination of spatial and time resolution for smooth representation of motion. In this variant can be used in any of light sources, shown in figa-2d. A light source creates a continuous blue/green lighting and alternating light red light/light near IR region of the spectrum. The imager in turn exhibit light fields, namely the first fields (half-frames)that contains the even lines sweep, alternately with the second field (or fields)that contains the odd lines sweep. On timing diagram, figure 4 shows the full frame rate of 30 fps, and during the same period of the field (16.7 MS) use lighting light near IR region of the spectrum, and after that during two periods of the field (33,3 MS) lights red. In other words, a sample of tissue or light rays in full color spectrum (RGB) for two periods fields (33,3 MS) and then the combination of green light, blue light and light near IR spectral range during the third period of the field. For reconstruction of full-color images in the visible spectrum lost information of red light restore through interpolation between two fields adjacent to the field corresponding to irradiation with light near IR region of the spectrum. Information blue and green image has always get optimal and continuous luminance information. The picture in the near IR region of the spectrum generated on the basis of every six fields in each of the fields where the lost row restore through spatial interpolation. When you view the display fields luminescence picture updates every three fields, and present to get the image using interpolation between odd and even scan lines.

On all the plans of the term "IR (infrared) is used instead of, or used interchangeably with the term "NIR" (near infrared (IR) region).

After data processing of color images and images in the near IR region of the spectrum transmit a signal to a video display, where the image can be represented in the form of two separate simultaneous images (one image color and one image luminescence) or in the form of imposition of signals color image and the image of luminescence (for example, by assigning the signal, representing the image of luminescence, colours contrasting with natural colours of the fabrics).

Figure 5 shows the timing diagram example of the second option is implemented with the simultaneous receipt and submission of a color image and the image in the near IR region of the spectrum. In this variant, the imager in the composition of the camcorder using the format produce images with progressive scan, when full frame (green/blue/red (G/B/R) alternately with green/blue/near IR (G/B/NIR)) gain for each period of the field. In this variant can be used in any of light sources, shown in figa-2d. The light source creates a continuous blue/green lighting and striped red lighting/lighting in the near IR region of the spectrum. On timing diagram shown in figure 5, during the same period of the field (16.7 MS) throw light near IR region of the spectrum, then during the same period of the field (16.7 MS) lights red. In other words, a sample of tissue or light rays in full color spectrum (RGB) during the same period of the field (16.7 MS) and then the combination of green light, blue light and light near IR spectral range during the third period of the field. In this case, full-color images in the visible spectrum is available in every pixel in every second frame. In these alternating frames information blue and green color is obtained directly, while information red color is obtained by interpolation between adjacent frames. Unlike options, shown in figure 4, spatial interpolation is not required here. Further processing of the image and view it on the display can be implemented in a way similar to method described in the previous versions.

Figure 6 shows the timing diagram example of the third variant, when the green/blue lights and lighting light near IR region of the spectrum is continuous, and modulate only red light. The same version, shown in figure 4, the imager in turn exhibit light fields, namely the first fields (half-frames)that contains the even lines sweep, alternately with the second field (or fields)that contains the odd lines sweep. On timing diagram Fig.6 shows the full frame rate 30fps, and during the same period of the field (16.7 MS) use lighting light near IR region of the spectrum and green/blue lights (NIR+GB) (red light is off), then during two periods of the field (33,3 MS) use lighting light near IRregion of the spectrum and the red/green/blue lights (NIR+RGB). If the signal near IR spectral region is weak in comparison with the received signal red light, he will not have a material impact on the full image in the visible region of the spectrum (RGB), so color image can be created through the normal processing of color images without correction. In otherwise contribution signal near IR region of the spectrum obtained in the red channel of the image when the red light is off, you can subtract from the image data in the near IR region of the spectrum and red spectral range (NIR+R) through spatial and temporal interpolation for the signal red image, as shown in the rows from the second to the last on time diagram 6. Alternatively, you can use the CMOS imagers with getting in progressive scan format similar to that shown in figure 5, and receive full-color visible (RGB) image and the combination of this image with the image in the near IR region of the spectrum (RGB+IR) in alternating frames.

In the example of another version (not shown) green/blue lights is continuous, and modulate the light exposure near IR region of the spectrum. This way synchronization can be best applied when the red image and image signals in the near IR region of the spectrum are about the same size. In this variant, the light source creates a continuous coverage of the full spectrum of visible light and intermittent lighting light near IR region. The timing diagram in this case is essentially the same as figure 6, but the lighting light near IR region of the spectrum and the red light will be swapped. Intermittent lighting light near IR region of the spectrum synchronized in such a way as to correspond with every third field in the camera interlaced or every second field in the camera with progressive scan. For each field, where there is coverage of light near IR region of the spectrum, the driver of the red image gets the total signal red images and images in the near IR region of the spectrum (R+NIR). The image signal in the near IR region of the spectrum can be drawn from the total signal red images and images in the near IR region of the spectrum (R+NIR) by interpolation of the values of the red signal on the basis of relevant preceding and subsequent fields only "red" image and then subtract the received signal red images of the total signal red images and images in the near IR region of the spectrum (R+NIR). Because the signals of the red images and images in the near IR region of the spectrum have similar characteristics, such interpolation and subtraction give the value of the image signal in the near IR spectral range with reasonable accuracy. The color image is processed using the obtained as a result of receiving and interpolated signal red image combined with tones of blue and green images. The resulting information colored images in the visible spectrum and image information in the near IR region of the spectrum can then be displayed or recorded, as described previously.

In any of the above endoscopic visualization system with the use of images in the near IR region of the spectrum can also work in such a way that the light source is continuously lights or light full visible spectrum or light near IR region of the spectrum and the camera gets the corresponding color images in the visible spectrum or image in the near IR region of the spectrum (absorption or luminescence) continuous way to achieve high spatial resolution. The resulting video in any mode, individual lighting/visualization color in the visible spectrum or in the near IR region of the spectrum, can be further presented on the display and/or recorded.

Although the present invention has been described in connection with the preferred options, shown and described in detail, specialists in this area will be obvious its various modifications and improvements. For example, instead of using a separate signal conditioners image to produce green/blue (G/B) image and red/near infrared (R/NIR) of the image, or one color imager to produce images of the primary colors (RGB) and images of luminescence in the rays of the near IR region of the spectrum, to use one imager with getting the three primary colors (RGB), implemented with a multi-layered arrangement of pixels CMOS technology and sold, for example, the firm Foveon, Inc., San Jose, CA. This imager is schematically represented in the Fig.7. It should be understood that such design of the imager can be extended up to four colors by adding a layer of light-sensitive near IR region of the spectrum. Thus, the image of the red, green, and blue color and image in the near IR region of the spectrum receive imager at different depths. When using a 4-layer imager multiplexing light red area and near IR spectral region will become unnecessary. However, in the case of a 3-layer imager red lighting and lighting in the near IR spectral region still have to MUX, as described above for normal camera with three imager. In applications where visualize the image of luminescence also need suitable barrier filter to block radiation excitation in the near IR region of the spectrum.

Although the present invention has been illustrated and described in connection preferable at the moment options shown and described in detail, it should not be limited given the details, because they can be made with various modifications and structural changes, not leaving any way outside of the spirit and scope of the present invention. The options considered were selected and described the purpose clarification of the principles of the present invention, and its practical application, that allows the expert in the field the best use of the present invention, and different ways with different versions adapted for alleged specific use.

New signs that are to be protected by a patent for invention, formulated in the accompanying claims and equivalents include elements described here.

1. The method of obtaining images in the near IR region of the spectrum and full-color images that contain stages, : continuous light of the observed area in blue/green light of the observed area is red and light near IR region of the spectrum, with a red light and/or light near IR region of the spectrum periodically turns on and off, send reflected light blue, green reflected light and total red reflected light and fluorescent radiation in the near infrared area of a spectrum on one or more CMOS imagers, made with the possibility of separate measurements of the reflected blue light reflected green light and the total of the reflected red light and fluorescent radiation in the near infrared region of the spectrum, this measures the reflected red light and fluorescent radiation in the near infrared region of the spectrum synchronously switching red light and light near IR region of the spectrum, determined separately spectral component of the reflected red light and spectral component of the fluorescent radiation in the near infrared region of the spectrum on the basis of the signals of the total image of the reflected red light and fluorescent radiation in the near infrared region of the spectrum display full color image of the observed region on the basis blue reflected light, green Ohr Hozer separately and certain spectral component of red light, and display the image in the near IR region of the spectrum on the basis of spectral component of the fluorescent radiation in the near infrared region of the spectrum.

2. The method according to claim 1, wherein the observed region alternately light red light and light near IR region of the spectrum.

3. The method of claim 2, in which the light duration red light the same as the duration of illumination light near IR region of the spectrum.

4. The method according to claim 3, in which the light duration red light, more light duration light near IR region of the spectrum.

5. The method of claim 2, in which the light duration red light is essentially identical to the duration of illumination light near IR region of the spectrum.

6. The method according to claim 1, wherein the observed region continuously lights red and periodically throw light near IR region of the spectrum.

7. The method according to claim 1, wherein the observed region continuously throw light near IR region of the spectrum and occasionally illuminate red.

10. The method according to claim 7, in which the spectral component of light near IR region of the spectrum obtained in the absence of light red light, subtract from the total of the reflected red light and fluorescent radiation in the near infrared region of the spectrum to get an individual spectral component of the reflected red light.

11. The method according to claim 1 in which the spatial information on the observed region have mainly on the basis of the reflected light blue and green light reflected.

12. Visualization system for images in the near IR region spectrum and full-color images containing: the source of light for illumination of observed area is the visible light and near IR region of the spectrum, a video camera, containing one or more imager, designed to measure separately reflected blue reflected light green light, and the total of the reflected red light and fluorescent radiation in the near infrared spectral range, returning from a certain area, the controller is made with the possibility of communicating with the light source and camera for continuous lighting the observed areas in blue/green lighting of observed area is red and light near IR region of the spectrum, with a red light and/or light near IR region of the spectrum periodically turns on and off, and determine separately spectral component of the reflected red light and spectral component of the fluorescent radiation in the near infrared region of the spectrum on the basis of the total of the reflected red light and fluorescent radiation in the near infrared region of the spectrum synchronously switching red light and light near IR region of the spectrum, and the display, made with opportunity to receive signals of images corresponding reflected blue light, green light reflected separately and certain spectral component of the reflected red light, and play on their basis of full-color image of the observed area, with advanced display made with the possibility to take separately certain spectral component of the fluorescent radiation in the near infrared region of the spectrum and play on its basis the image of the observed area in the near IR region of the spectrum.

13. Visualization system indicated in paragraph 12, in which the observed region alternately illuminated with red light and light near IR region of the spectrum.

14. Visualization system indicated in paragraph 12, in which the light source contains the illuminator, made with the possibility of radiation of visible light and light near IR region spectrum essentially constant intensity in the continuous spectrum range, and a few filters, located between the illuminator and the observed area for bandwidth continuous in time blue/green light and discontinuous in time of red light and discontinuous in time of light near IR region of the spectrum.

15. Visualization system indicated in paragraph 12, in which the light source contains the illuminator, made with the possibility of radiation of visible light and light near IR region of the spectrum essentially constant intensity in the continuous spectrum range, first dichroic tool to divide visible light and light near IR region of the spectrum on the blue/green and red light and light near IR region of the spectrum, the circuit breaker to convert highlighted in red light and selected light near IR region of the spectrum in discontinuous in time red light and discontinuous in time light near IR region of the spectrum, and the second dichroic tool for summarizing blue/green light, intermittent in time of red light and discontinuous in time of light near IR region of the spectrum, for transmission to the observed region.

16. Visualization system indicated in paragraph 12, in which the light source contains the first illuminator, made with the possibility of emission of green and blue light essentially constant intensity, the second light, made with the possibility of obtaining switchable red light, the third illuminator, made with the possibility of obtaining switchable light near IR-region of spectrum, and dichroic tool for summarizing switchable red light and switched the light near IR spectral range with green and blue light, for transmission to the observed region.

17. Visualization system on article 16, which switched red light and switched the light near IR region of the spectrum are obtained by the interruption of the light beam of constant intensity red light and light near IR region of the spectrum through the blinds or breaker.

18. Visualization system on article 16, which switched red light and switched the light near IR region of the spectrum are obtained by the electric power on and off the second illuminator and third illuminator.

19. Visualization system indicated in paragraph 12, in which the CMOS imagers are interlaced.

20. Visualization system indicated in paragraph 12, in which the CMOS imagers are using a progressive scan signal.

21. Visualization system for para.12 containing additional block dichroic prism, spectral separating reflected blue light green light, and the total reflected red light and fluorescent radiation in the near infrared spectral range, returning from the observed region, and the guide is divided light on different weekends verge block dichroic prism, with the specified one or more imager contains three imager, each of which is established on their own, different from other output face.

22. System visualization indicated in paragraph 12, in which the specified one or more imager contains one imager with pixels, where each pixel reacts on returning from the observed area is reflected blue light or reflected light, or the total the reflected red light and fluorescent radiation in the near infrared region of the spectrum.

23. Visualization system on article 22 where the specified one imager contains a mosaic matrix color blue/green/red-near-infrared colors, in front of the pixels of the imager.

24. Visualization system indicated in paragraph 12, in which specified one or more imager contains one imager with a number placed one on another layer, and each layer has pixels that responds to returning from the observed area is reflected blue light or reflected light, or total reflected red light and fluorescent radiation in the near infrared region of the spectrum.

25. Visualization system for para.12 where made in the form of an endoscope.