Bandage with prolonged detection of active substances

FIELD: medicine.

SUBSTANCE: bandages based on polysulphated oligosaccharides showing prolonged release of said active substances, and a process for their preparation are described, wherein the method comprises the step of treating with ethylene oxide. The invention relates to the use of these bandages for wound care and for the treatment and/or prevention of scar formation and skin stretch marks.

EFFECT: high release of active substances.

16 cl, 4 dwg, 2 ex

 



 

Same patents:

Crystals // 2556206

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention describes crystals of 2-{4-[N-(5,6-diphenylpyrazin-2-yl)-N-isopropylamino]butyloxy}-N-(methylsulphonyl)acetamide ("compound A"), as a form I of the compound A crystal, which shows diffraction peaks at 9.4 degrees, 9.8 degrees, 17.2 degrees and 19.4 degrees in its power X-ray diffraction spectrum, as a form II of the compound A crystal, which shows diffraction peaks at 9.0 degrees, 12.9 degrees, 20.7 degrees and 22.6 degrees in its power X-ray diffraction spectrum, as a form III of the compound A crystal, which shows diffraction peaks at 9.3 degrees, 9.7 degrees, 16.8 degrees, 20.6 degrees and 23.5 degrees in its power X-ray diffraction spectrum. There are also described methods for producing the forms I, II and III of the compound A crystal, based pharmaceutical composition and PGI2 receptor agonist agent, an accelerating agent for angiogenic therapy, gene engineering or autoimmune bone marrow transplantation, and an accelerating agent for angiogenesis for peripheral artery recovery or angiogenic therapy on the basis thereof; there are also described a preventive or therapeutic agent for a wide range of diseases and conditions.

EFFECT: preparing the new therapeutic agent for the wide range of diseases and conditions.

11 cl, 6 dwg, 6 tbl, 5 ex

FIELD: medicine.

SUBSTANCE: invention concerns using synthetic peptide of general formula H2N-L-Glu-L-Trp-D-Ala-COOH as a wound healing agent possessing the immunostimulatory effect.

EFFECT: creating the new synthetic wound healing agent having high biological activity.

2 tbl, 2 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to oxazolopyramidine compounds of formula I, where A represents O; R1 is selected from phenyl or pyrimidine, which are optionally substituted with R11; R2 represents phenyl, which is optionally substituted wby 1-3 ring carbon atoms with similar or different substituents R22, R11 represents halogen; R22 is selected from hydroxy group, (C1-C4)-alkyl, which is optionallysubstituted with 1-3 atoms of fluorine, (C1-C4)-alkyloxy, (C1-C4)-alkyl-S(O)m-; m equals 2. Invention also relates to pharmaceutical composition, which contains formula I compounds, and to method of obtaining formula I compounds.

EFFECT: formula I compounds, intended for activation of EDG-1 receptor and applied for wound healing.

15 cl, 2 tbl, 2 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to oxazolopyramidine compounds of formula (I), where A represents O; X represents (C1-C6)-alkanediyl or (C1-C6)-alkanediyloxy, where oxygen atom of (C1-C6)-alkanediyloxy is bound to group R2; Y represents pyrrolidinyl; R1 represents (C1-C4)-alkyl; R2 represents phenylene, optionally substituted by one or two carbon atoms in ring with similar or different substituent R22; R3 is selected from group, which consists of cycloalkyl-CuH2u-, where u equals 1; radical of saturated 3-10-member monocyclic ring, phenyl or pyridyl, where ring radical is optionally substituted by one or two carbon atoms of ring with substituent R31; R4 represents hydrogen; R22 represents (C1-C4)-alkyl; R31 is selected from group, which consists of halogen and (C1-C4)-alkyl. Invention also relates to (S)-l-[2-(2,6-dimethyl-4-{5-[methyl-(3,3,3-trifluoropropyl)amino]-7-propoxyoxazolo[5,4-d]pyrimidine-2-yl}phenoxy)acetyl]pyrrolidine-2-carboxylic acid, pharmaceutical composition and to method of obtaining compounds of formula (I) .

EFFECT: compounds of formula (I), intended for activation of EDG-1 receptor and applied for wound healing.

16 cl, 2 tbl, 2 ex

FIELD: veterinary medicine.

SUBSTANCE: wound is preliminary treated with antiseptics. Then the preparation is injected drug directly under the base of the lesion. The preparation is used as the extract from the reindeer velvet antlers at a dose of 5-10 ml per one wound three times, once every 5 days.

EFFECT: use of the preparation Pantoin, the extract of reindeer velvet antlers, enables to speed up significantly the healing process of tear-contused wounds in horses and facilitates significantly the process of wound healing, particularly in the pasture period of maintenance.

2 tbl, 5 ex

FIELD: medicine.

SUBSTANCE: ointment contains wax 13-15 wt %, glycerol 15-20 % and vegetable oil; the prepared ointment mass is exposed to ozone for 15-20 min in a yield amount of 10 mg/l.

EFFECT: invention provides the advanced healing efficacy with no side effects by reducing the time of wound cleansing from purulo-necrotic tissues.

3 ex

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to combustiology, and can be applied in process of treating burn wounds of III a and III b degree. For this purpose applied are cultured dermal allofibroblasts on 5-8 passage with concentration 250000 cells/ml as part of composition, which includes as carrier hydroxyethylcellulose natrosol and native collagen. After uniform distribution of medication on wound surface relief fixing with inert mesh covering "Lomatul-N" is carried out.

EFFECT: invention makes it possible to achieve fast recovery skin, reduction of probability of burn disease complications, improvement of functional and cosmetic results of treatment.

1 dwg, 2 ex

FIELD: medicine.

SUBSTANCE: burn-treating composition for local application based on Vaseline lanolin, or carbopol, or hydrogel; as an active substance, the composition contains 5% dry extract of the herbal raw material big-flowered self and self-heal containing 60% rosmarinic acid.

EFFECT: above composition is effective for treating burns; it is non-toxic.

7 tbl, 10 ex, 12 dwg

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to physiotherapy, dermatology and cosmetology, and can be used in stimulating regenerative processes in the face and/or neck skin. That is ensured by performing three stages, first two of which involve preparing to the third one. The first stage involves blood sampling from the patient, recovering the blood plasma, and enriching it with thrombocytes; the purified and enriched plasma is administered intradermally under the skin. Two days later, the second stage follows that involves the subcutaneous injections of hyaluronic acid. The third stage is performed 2-3 days later to expose different skin layers to laser light passing through different face and/or neck sections two to five times for one procedure. Passing once involves the alternating short-wave and long-wave laser exposure at a wave length of 1564-2940 nm. The procedure is repeated every 3-5 days with an increasing laser beam pulse energy from 35 mJ to 65 mJ.

EFFECT: method provides the safe effective stimulation of the regenerative processes in the face and/or neck skin ensured by the complex exposure covering different layers of derma and epidermis and involving different regeneration links.

2 ex

FIELD: medicine.

SUBSTANCE: invention represents an agent for treating septic wounds, pus pockets and trophic ulcers containing betaine hydrochloride, methyluracil, trimecaine, pepsin powder and polyethylene oxide 400 with the ingredients taken in certain proportions, wt %, and polyethylene oxide 400 is taken in an amount of 87.0-84.0 ml.

EFFECT: invention provides fastening necrolysis, intensifies bactericidal action, stimulates regeneration, prevents secondary infection.

4 ex

Wound shield // 2554805

FIELD: medicine.

SUBSTANCE: invention refers to medicine, more specifically to a wound shield for wound healing in a humid or humid-moist medium containing a suction and washing body made of a fibre nonwoven fabric, wherein a superabsorbent material is distributed; during the process, the suction and washing body is impregnated with a saline solution, particularly Ringer's solution, preferentially until saturated, and a coating forming outer visible sides of the wound shield; a film layer can be applied from the side of the suction and washing body. The wound shield comprises a cationic substance of microbial action, which is attracted by negative groups of the anionic superabsorbent material, and thereby has antimicrobial action inside the suction and washing body; from the side facing the wound, the coating is provided with an outer partial structured non-traumatic coating (16) having the coverage of no more than 70%.

EFFECT: wound shield prolongs the replacement-free period.

14 cl, 3 dwg

FIELD: medicine.

SUBSTANCE: invention relates to medicine. Cooling products and methods of their manufacturing are described. The cooling product consists of a substrate, soaked with a polymer gel and an antimicrobial agent. The product can represent a compression wrap, a laid-on pad, a body wrap, a container wrap, a blanket or an item of clothing.

EFFECT: cooling product does not subject the user to the impact of potentially extreme temperatures, preserves its integrity in the course of time and is reusable.

32 cl, 17 dwg

FIELD: medicine.

SUBSTANCE: group of inventions refers to medicine. What is described is a haemostatic device comprising a carrier material, a surface of which is coated with a printed pharmaceutical composition containing thrombin. What is described is a method for making the haemostatic device comprising the carrier material, the surface of which is coated with the printed pharmaceutical composition. What is described is using the haemostatic device for fastening haemostasis and/or wound healing. The invention also refers to a kit comprising the carrier coated with the pharmaceutical composition and a container with a detachable lid.

EFFECT: printing method enables distributing the composition more accurately on the surface of the carrier material.

32 cl, 7 dwg, 5 tbl, 5 ex

FIELD: medicine.

SUBSTANCE: invention refers to medicine, particularly to a method for active substance (AS) delivery through an epidermal barrier. The declared method involves using a matrix-type transdermal patch containing a substrate, a protective tape and a polymer layer, and characterised by the fact that 10% PEG-12 dimethicone niosomes are introduced into the polymer layer of the transdermal patch; then the substrate is coated with the polymer layer. The ACs are encapsulated into the niosomes with the use of hemogeniser APV, as well as 10 wt % propylene glycol and 5 wt % isopropyl myristate.

EFFECT: improving the active substance penetration with maintaining the biological activity and prolonging the active substance action.

2 tbl, 3 ex

FIELD: medicine.

SUBSTANCE: invention refers to medicine. What is described is a method for producing a therapeutic tissue involving producing a polymer base containing alginic acid salt, administering an active substance in a therapeutically effective amount, agitating the mixture in a slow-speed mixer, applying the prepared composition on a textile material containing at least 50% cellulose fibres, while the composition of the polymer with the active substance is applied on the textile material through a mesh template at a cell size of 200 to 450 mcm to generate a continuous polymer layer on the face surface of the textile material not penetrating to the inner side.

EFFECT: method enables extending the range of therapeutic agents and biologically active additives, enabling variation of their concentration that causes their concentration in treating various diseases, enables fast transformation of the technological process and its cost-effectiveness.

28 cl, 23 ex

FIELD: medicine.

SUBSTANCE: invention refers to medicine, more specifically to a biodegradable absorbent polymer produced from a composition with nitrogen-containing heterocyclic monomer, polymerized acryl or methacryl, a non-organic excipients and an allyl compound of cellulose.

EFFECT: biodegradable absorbent polymer has excellent biodegradability and high absorbing capacity.

11 cl, 3 tbl, 2 dwg, 5 ex

FIELD: medicine.

SUBSTANCE: what is described is a non-woven fabric consisting of several layers and comprises spot-glued carrier with polyamide nanofibres containing at least one antimicrobial substance, and a protecting coat. The polyamide nanofibres are made of polyamide and can be fixed on the carrier by means of a liquid adhesive. Non-woven fibre fabrics of the density of 15 to 90 g/m2 are used as the carrier of the nanofibres and protecting coat: polypropylene, polyester, cellulose-polyester, cellulose or paper. The polyamine nanofibres contain at least one antimicrobial substance in an amount of 0.4 to 35% of nanofibre weight among: guanidines, metal nanoparticles, stabilised silver salts, quaternary ammonium compound salts.

EFFECT: material possesses antimicrobial activity, high air permeability, and fracture resistance.

9 cl, 2 dwg, 5 ex

FIELD: medicine.

SUBSTANCE: invention relates to medicine. Described is method of treating infection of human or animal body surface, in particular, contamination with fungi, including application of water liquid on infected body surface, for instance, nail area, with further application of bandage, which includes hydrogen peroxide source. Combinations of bandage liquid for application in method are also provided.

EFFECT: combination makes it possible to considerably reduce or eliminate infection in nail area.

16 cl, 1 tbl, 2 dwg, 2 ex

FIELD: medicine.

SUBSTANCE: what is described is hydrogel composition containing sodium acrylate, a linking agent, biologically active substances, polyvinyl pyrrolidone, glycerol, propanediol, water, a catalyst agent and a radical polymerisation indicator in the following proportions, wt %: sodium acrylate 2.0-10.0, catalyst agent 0.045-0.48, linking agent 0.195-0.21, radical polymerisation indicator 0.045-0.06, glycerol 4.5-7.5, propanediol 3.0-10.5, biologically active substances 0-1.5, polyvinyl pyrrolidone 0.3-1.5, water - the rest. What is described is a surgical dressing containing a carrier with the hydrogel composition applied thereon.

EFFECT: higher efficacy of the hydrogel composition and surgical dressing thereof, lower labour intensity of the method for preparing the above composition.

10 cl, 1 tbl, 2 ex

FIELD: medicine.

SUBSTANCE: dressing represents a knitted mesh fabric coated with a composition of a biocompatible film-forming polymer of polyvinyl pyrrylidone and drug preparations: iodine, novociane, carboxymethyl cellulose sodium salt, of the following formulation (mg/cm2): iodine 0.028220%; polyvinyl pyrrylidone (Mr 20000) 1.220%; novociane 0.42620%; carboxymethyl cellulose sodium salt 1.6-1.9.

EFFECT: using the wipe provides antimicrobial, antiseptic, disinfecting, antifungal and antiprotozoal action ensured by the fact that a polyvinyl pyrrylidone matrix retains iodine in the wipe and promotes its release on the skin.

FIELD: medicine.

SUBSTANCE: group of inventions refers to medicine. What is described is an absorbent product comprising an upper sheet, a lower sheet, an absorbent core between the upper sheet and the lower sheet, and a cyclodextrine complex containing cyclodextrine and at least three components bound to the cyclodextrine complex. The absorbent product has a total chromatographic peak area of the components released from the cyclodextrine complex into a closed space at the moment of time of 0 min is no more than approximately 0.50108, a total chromatographic peak area of the components released from the cyclodextrine complex into the closed space at the moment of time of 30 min is at least approximately 1.00108 and a total chromatographic peak area of the components released from the cyclodextrine complex into a closed space at the moment of time of 240 minutes is at least approximately 2.70108.

EFFECT: absorbent product provides the effective release of the components of the cyclodextrine complex to reduce a body fluid odour.

10 cl, 4 dwg, 3 tbl, 3 ex

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