Flavonoid-based composition for pharmaceutical, dietary or cosmetic application with enhanced antioxidant action
SUBSTANCE: pharmaceutical composition possessing antioxidant activity against free radicals, containing: a) extract of seeds or seeds and leaves of Vitis vinifera, including a combination of quercetin and catechin flavonoids content at a molar ratio in the range from 6:1 to 3:1, or a') extract of seeds or seeds and leaves of Vitis vinifera, including a combination of quercetin and catechin flavonoids content at a molar ratio in the range from 7:1 to 4:1, or a") blend of Vitis vinifera extracts of a) and a'), or a'") a mixture of catechin and quercetin at a molar ratio in the range from 7:1 to 3:1, along with b) Olea europaea L. olive leaves extract containing hydroxytyrosol in an amount ranging from 1% to 30% of the extract mass, or b') hydroxytyrosol in an amount equal to the one contained in the extract (b), wherein the a'), or a"), or a"') and b), or b') ration is in the range between 6:1 to 6:3. Cosmetic application of the composition to provide antioxidant activity against free radicals. Composition application as a food dietary supplement to provide antioxidant activity against free radicals.
EFFECT: compositions described above have a pronounced synergistic antioxidant activity.
22 cl, 2 dwg, 8 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention relates to pharmaceutical industry, namely represents composition, which contains mixture of particles of hydrophobic silicon dioxide aerogel, which have specific area of surface per weight unit (Sw) in range from 500 to 1500 m2/g and size, expressed in form of volume mean diameter (D[0.5]), in range from 1 to 1500 mcm, and at least one first linear silicone oil, which has viscosity higher than 50 mm2/s, and at least second and third linear silicone oils, and each of them has viscosity lower than or equal 50 mm2/s.
EFFECT: mixture of particles of silicon dioxide aerogel and linear oils provides possibility of obtaining compositions, which provide comfort and smoothness of skin after application and have dullness and "soft focus"-adding properties.
23 cl, 8 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: group of inventions refers to an antiseptic pharmaceutical composition applicable for oral hygiene and treatment of microbial oral diseases, to a method for producing and using it. The composition contains from 0.05 to 0.3 wt % of hydrogen peroxide or its equivalent amount in the form of carbamide peroxide, from 0.001 to 0.03 wt % of eugenol, from 0.001 to 0.01 wt % of camphor, from 0.001 to 0.5 wt % of a salt of zinc or other heavy metals, such as silver, mercury, copper or a mixture thereof; from 1 to 1.2 wt % of sodium fluoride; from 2% to 7 wt % of xylitol, from 0.002 to 0.05 wt % of cetylpyridinium chloride and excipients in an amount sufficient to reduce the composition to 100%. The composition possesses a wide spectrum of action. What is also presented is a method for producing the composition and using it for producing a therapeutic agent effective for odour elimination, suppression and relief of an oral inflammation, dental tartar inhibition; for treating oral diseases; for rinsing and treating orthodontic damages; for preventing oral diseases during orthodontic treatment after oral operations and in the patients using fixed and temporary dentures; for relieving, treating or preventing oral diseases in different categories of patients, such as the patients receiving radiation therapy or chemotherapy, hospital patients and terminally ill patients, patients suffering from eating disorders, endocrine, haematological, cardiovascular and psychosomatic disorders, and besides physically or mentally deprived patients, patients with genetic or inherited changes.
EFFECT: preparing the antiseptic pharmaceutical composition.
22 cl, 3 ex
SUBSTANCE: invention relates to field of cosmetology and describes method of stopping unwanted hair growth on different body parts, characterised by the fact that first mechanical removal of hair with root on selected part of skin is performed with further application on said zone with open follicle ostia of depilatory based on salts of thioglycolic acid, sodium, potassium and calcium hydroxides and following rubbing to provide penetration of depilatory into hair follicle.
EFFECT: invention provides possibility of simultaneous destruction of hair follicle with preparations, allowed in medicine and cosmetology.
SUBSTANCE: invention relates to cosmetic industry and provides a composition for depositing on keratin surfaces, which contains composition particles in the form of fused agglomerates having a part containing at least one dye and a part containing at least one transparent and translucent thermoplastic material, where the composition particles contain, based on the weight of all of the powdered composition material, about 10 to 90 parts of the dye part and about 90 to 10 parts of the transparent and translucent thermoplastic material part, and a method of producing the powdered composition material.
EFFECT: invention enables to obtain cosmetic compositions which will have an improved outer appearance on the skin and fewer SKU.
23 cl, 10 tbl, 11 ex
SUBSTANCE: invention refers to dentistry, namely represents an encapsulated oral care composition and an oral care device. According to the invention, the composition contains: (a) a gelatine capsule; and (b) an oral care composition inside the capsule and containing: (i) a hydrophilic active ingredient, (ii) a hydrophobic structuring ingredient, and (iii) an oil carrier. The hydrophilic active ingredient preferentially represents cetylpyridinium chloride. The hydrophobic structuring ingredient preferentially represents gelated mineral oil.
EFFECT: developing the composition according to the invention solves the problem of cetylpyridinium chloride migration and fish-eye capsule defect.
9 cl, 1 ex, 1 tbl
SUBSTANCE: claimed invention relates to cosmetic field, namely represents method of colouring or lightening of keratin fibres, which includes stage of mixing without preparation at the moment of application of two compositions (A) and (B) and application of said mixture on said fibres; with said mixture including, at least, 25% of fatty substances relative to the total weight of composition, obtained in mixing two compositions (A)+(B).
EFFECT: method by invention makes it possible to produce intensive and uniform colouring of keratin fibres, with method simultaneously being easy to realise, because mixture in form of oil-reach emulsion does not flow down, but remains on application place, as well as makes it possible to lighten keratin fibres.
19 cl, 3 tbl, 1 ex
SUBSTANCE: shower gel comprises lauryl glucoside, sodium carboxylate and lauryl glucoside, coco glucoside, cocon amidopropylbetaine, guar-hydroxypropyltrionium chloride, coco glucoside and glyceryl oleate, ethyl alcohol, a fragrance component, sanguinitrine derived from small-fruited plumepoppy, citric acid and water. The components of the gel are in a certain ratio in wt %.
EFFECT: invention provides high washing and foam-generating capacity with soft action which does not disturb the lipid layer of the skin and has a disinfecting action, without destroying own microflora of human skin.
FIELD: medicine, pharmaceutics.
SUBSTANCE: group of inventions relates to liposomal compositions for application in cosmetic industry, including i) from 0.001 to 1 wt % of cyclo-(Arg-Gly-Asp-DPhe-Acha) and/or its salt or solvate, ii) from 0.01 to 20 wt % of one or more lipids; iii) from 60 to 99.99 wt % of one or more physiologically acceptable solvents, as well as to method of their obtaining and application for care and preservation of general condition of skin or hare, for prevention or reduction of wrinkles.
EFFECT: claimed compositions demonstrate favourable properties: improved effectiveness, higher stability, reduced immunogenic reactions in comparison with known properties.
18 cl, 3 dwg, 29 tbl, 18 ex
SUBSTANCE: present invention relates to cosmetology and hygiene and provides a foaming detergent composition which contains: a) surfactants consisting of decyl glucoside and coco glucoside, where the decyl glucoside is present in an amount by weight which is 1.8 to 2.2 times the weight of coco glucoside, and b) water, where the amount of decyl glucoside is 10 to 30 wt % of the composition, wherein the composition is free of anionic surfactants.
EFFECT: invention enables to produce a detergent composition having foaming properties in the absence of an anionic surfactant that are equally effective as with a composition with an anionic surfactant.
23 cl, 6 ex
SUBSTANCE: invention is the biological means for cleaning and restoration of skin, comprising pancreatic tissue of pigs or birds, 70% ethyl alcohol, fragrance component, and Ringer's solution, at that the components in the means are in a certain ratio, in wt %.
EFFECT: acceleration of the process of skin regeneration, expanding of range of means having cleaning and skin restoring action.
3 dwg, 1 tbl
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to pharmaceutical industry, namely to selenium nanocomposites of natural hepatotrophic galactose-containing polysaccharide matrixes, representing water-soluble orange-red powders containing zerovalent selenium (Se0) nanoparticles sized 1-100 nm in the quantitative content of 0.5 - 60 wt %, possessing antioxidant activity for treating and preventing redox-related pathologies, particularly for treating toxic liver damage, to a method for producing and to an antioxidant agent containing the above nanocomposites.
EFFECT: invention provides the targeted agent delivery to liver cells, as well as higher agent accessibility and lower toxic action of selenium.
7 cl, 11 ex, 4 tbl
SUBSTANCE: method involves chelation of ferric (III) ions both in vivo, and in vitro with using 2-ethyl-6-methyl-3-hydroxypyridine succinate (Mexidol) to produce a stable stained complex having a high molecular weight and a complex (organic-inorganic) composition not identified among the known compounds.
EFFECT: high effectiveness of the chelation process and low toxicity of Mexidol that makes it promising for biomedical application.
4 dwg, 3 tbl, 3 ex
SUBSTANCE: invention relates to field of organic chemistry, namely to novel compound - 5(6)-nitro-1-(thietanyl-3)-2-ethoxybenzimidazole, inhibiting peroxidation of lipids.
EFFECT: novel compound, possessing useful biological properties, has been obtained.
2 cl, 1 dwg, 2 ex
SUBSTANCE: invention represents a mixture of two structural isomers: 2,6-di(1,7,7-trimethylbicyclo[2.2.1]hept-2-yl)-4-methylphenol and its diastereomers, and 2-(1,7,7-trimethylbicyclo[2.2.1]hept-2-yl)-6-(2,2,1-trimethylbicyclo[2.2.1]hept-5-yl)-4-methylphenol, and their diastereomers with the ratio of the first and second structural isomer isomers from 60:40 wt % to 95:5 wt %.
EFFECT: extension of the arsenal of means, possessing simultaneously haemorheological, anti-aggregate, anti-thrombogenic, retinoprotecting, endothelium-protecting, neuroprotecting, anti-arrhythmia and anti-ischemic activity, enhancing the cerebral blood flow.
4 dwg, 20 tbl, 6 ex
SUBSTANCE: what is presented is using Histochrom (same as echinochrome A or pentahydroxyethyl naphthoquinone) as an agent able to prevent pulmonary fibrosis developed under cytostatic agents. The invention can be used for the pharmacological prevention and correction of the pulmonary tissue disorders caused by administering the cytostatic agents.
EFFECT: preventing hypertrophy of interalveolar connective tissue in the lungs associated with administering bleomycin.
4 dwg, 1 tbl
SUBSTANCE: drops possessing antiviral and immunomodulatory effects characterised by the fact that they represent a 95% ethanol infusion of wild strawberry leaves and fruit specified in: red raspberry fruit, mountain ash fruit, bilberry fruit, blood-red hawthorn fruit, cinnamon rose fruit; 15-25 mg of the substance in 1 ml of the infusion.
EFFECT: drops possess pronounced antiviral and immunomodulatory effects.
15 tbl, 5 ex
SUBSTANCE: melanin having water-solubility of at least 80% and an paramagnetic centre concentration of at least 8·1017 spin/g is administered orally into the animals having been exposed to the radiation in a dose high enough to cause a spinal radiation injury; melanin is administered after dissolved in distilled water in the effective concentration. Melanin water is used as drinking water for the mice having been exposed to single and fractionated acute radiation, which is able to cause acute radiation disease. Melanin water is taken from the 1st to 30th day following the single radiation, or from the 1st day of the fractionated radiation to the 30th day on completion of the radiation.
EFFECT: higher survival rate, faster recovered haemopoiesis, body weight and orientation and motion activity.
7 tbl, 5 ex
SUBSTANCE: invention provides a composition having antioxidant properties in the form of a tablet, comprising an active agent based on nicotinamide adenine dinucleotide in reduced form (NADH) and inert filling agents, characterised by that the active ingredient is a complex which is a mixture of 10 wt % NADH with 63 wt % vegetable fats, 17 wt % beeswax and 10 wt % chlorophyll, and the inert filling agents are in the form of microcrystalline cellulose, Macrogol 6000, intense sweetener and a food flavourant.
EFFECT: invention provides a new tablet form of NADH.
SUBSTANCE: invention refers to a pharmaceutical composition with anti-ischemic and antioxidant activity in the form of tablets or capsules, and a method for preparing it. The composition contains 4-((3-oxo-3-ethoxypropanoyl)amino)benzoic acid in an amount of 40 to 80 wt %, an amino-containing compound and pharmaceutically acceptable excipients. The amino-containing compound is specified in a group of trometamol, methyl glucamine and L-lysine; 1 mole of 4-((3-oxo-3-ethoxypropanoyl)amino)benzoic acid is accounted for 0.05 to 0.25 mole of the above amino-containing compound. The composition also contains lactose, microcrystalline cellulose, calcium stearate and other pharmaceutically acceptable excipients. According to the method for preparing the composition, taking 4-((3-oxo-3-ethoxypropanoyl)amino)benzoic acid and amino-containing compound in molar ratio 1:0.05 to 1:0.25, pre-mixing, moisturising with a aqueous or alcohol solution of a binding agent, adding pharmaceutically acceptable excipients in such an amount to provide the content of 4-((3-oxo-3-ethoxypropanoyl)amino)benzoic acid from 40 to 80 wt %, granulating the mixture, drying and producing tablets or capsules according to the known technique.
EFFECT: implementing the above application.
6 cl, 7 tbl, 4 ex
SUBSTANCE: claimed is the application of 5(6)-nitro-1-(1,1-dioxothietanyl-3)-2-chlorobenzimidazole of formula (I) , earlier known as the means with broncholytic and spasmolytic activity, as the means, inhibiting peroxide oxidation of lipids.
EFFECT: realisation of the claimed purpose.
SUBSTANCE: invention refers to veterinary science and consists in a method for cell immunity activation in vitro with homeopathic medicines. A leukocyte suspension 0.5 ml is added with a homeopathic medicine 0.5 ml diluted in normal saline; the prepared solution is placed into a thermostat for 1 hour at T=37±0.5°C; the solution is added with a microbial reference strain Staphylococcus albus No.182 suspension 0.5 ml containing 109 CFU in normal saline 1 ml; the new solution is placed into the thermostat for 30 minutes at T=37±0.5°C; after incubation, blood smears are fixed in alcohol-formalin for 10 minutes and stained according to Romanowsky-Giemsa for 30 minutes.
EFFECT: cell immunity activation.
3 tbl, 3 ex