Sulfo-containing polymers with its own antiviral activity
SUBSTANCE: invention relates to the high-molecular weight compounds of the medical purpose, more specifically to new synthetical sulfo-containing homo- and copolymers 2-acrylamido-2-methylpropansulfoacid with its own bioactivity that can be used in pharmacology in the capacity of the future-proof antiviral agents or can serve as the basis for the new effective and harmless antiviral medicinal agents and its pharmaceutical forms. The homo- and copolymers 2-acrylamido-2-methylpropansulfoacid of the stated below formula are obtained by the radical heterophase (co)polymerization in the ethanol at 70°C within 24 hours. The homo- and copolymers 2-acrylamido-2-methylpropansulfoacid have the molecular weight MM=(40-70)⋅103.
m=100 mol. %, n=0;
m=(22.8-58.1) mol. %, n=(77.2-41.9) mol. %.
EFFECT: invention allows to get nontoxical homo- and copolymer 2-acrylamido-2-methylpropansulfoacid with its own antiviral activity against the influenza viruses H3N2, H1N1.
1 tbl, 2 ex
SUBSTANCE: polyacryleamides are obtained by heterophase copolymerisation of vinyl monomers. First, n-dodecyclacrylamide is added to water solution of sodium dodecylsulfate, applied as stabiliser, with mixing. Then, water solution of acryleamide and acrylic acid is added to obtained dispersion. Reaction is carried out in alkaline medium at pH 9.5 with general concentration of copolymers from 3.0 to 3.8 mol/l. After that, particles of magnetic filler are added to obtained mixture with mixing in atmosphere of inert gas with gradual increase of reaction mass temperature from 20 to 55°C. Water solution of initiator, such as potassium persulphate or ammonium persulphate is added to obtained water dispersion to concentration 3.5-4.2 mmol/l. After that, obtained product is separated by known methods. As magnetic filler, applied is magnetite with particle size from 50 to 1000 nm or acicular particles of magnemite from 200 to 800 nm long with diameter from 20 to 50 nm. Magnetic liquid includes liquid phase - water or its mixture with organic solvents, such as ethanol methanol, and magnetic solid phase - upper said polyacryleamide.
EFFECT: invention makes it possible to obtain polyacryleamide by more technological economic method in absence of highly-toxic solvents and obtain magnetic liquid, which preserves sedimentation stability in magnetic field.
4 cl, 1 dwg, 1 tbl, 7 ex
SUBSTANCE: present invention relates to a comb-shaped copolymer comprising: (A) one or more repeating units obtained from olefinically unsaturated cationic or cation-active comonomers; and (B) one or more repeating units of formula where Y is a moiety which forms part of the copolymer backbone and is obtained from a monomer selected from at least one of the following monomers: olefinically unsaturated cationic or cation-active comonomers, acrylamide monomers, one or more olefinically unsaturated hydrophilic monomers, one or more olefinically unsaturated monomers; Z is a moiety capable of forming an associate with another moiety Z or other moieties in the preparation in which the copolymer will be used, and is a hydrophobic moiety selected from alkyl, aryl, aralkyl, fluoroalkyl groups having 8-50 carbon atoms, an organosilicon group having 35-25 linked SiO moieties, and silane; and b is a bond or a moiety, linking the moiety Z with a moiety Y, and represents covalent bonds formed by at least one ester, carbonyl, amide, amine oxide, hydrocarbon, amino, ether, polyoxyalkylene groups, or a bond resulting from ionic salt bonds. The invention also describes a personal hygiene product and a composition for the personal hygiene product containing said comb-shaped copolymer.
EFFECT: obtaining a comb-shaped cationic copolymer, which provides a balance of the required properties when used in personal hygiene products and other cosmetic preparations in terms of the sensory perception thereof and the degree of deposition or retention of active ingredients.
25 cl, 13 tbl, 73 ex
SUBSTANCE: claimed invention relates to a method of obtaining heterogeneous mixture used in the paper industry. Described is the method of manufacturing heterogeneous mixture of polymers, including: (a) introduction into a solution of the first portion of a polymerisation initiator and one or several anionic or cationic monomers, with monomers carrying the same charge; (b) introduction into the solution of the second portion of the polymerisation initiator and one or several non-ionic monomers; (c) introduction of the third portion of the polymerisation initiator and one or several ionic monomers, whose charge is opposite to the charge of monomers from (a); (d) gradual introduction of the fourth portion of polymerisation initiator for a reaction of any remaining monomer with formation of a heterogeneous mixture of polymers; and (e) in case of necessity neutralisation of the obtained heterogeneous mixture of polymers, with anionic monomers being selected from the group, consisting of: (1) acrylic acid, (2) methacrylic acid, (3) styrene sulfonic acid, (4) vinyl sulfonic acid, (5) acrylamido methylpropane sulfonic acid and (6) their mixtures; cationic monomers are selected from the group, which includes: (1) diallyldimethylammonium chloride, (2) acryloylethyl trimethylammonium chloride, (3) methacryloylethyltrimethylammonium chloride, (4) acryloylethyltrimethylammonium sulfate, (5) methacryloyl ethyltrimethylammonium sulfate, (6) acrylamidopropyltrimethylammonium chloride, (7) methacrylamidopropyl trimethylammonium chloride, (8) non-quaternised forms (2)-(7), (9) vinylformamide (further hydrolised into vinylamine) and (10) their mixtures, and non-ionic monomers are selected from the group, consisting of: (1) acrylamide, (2) methacrylamide, (3) N-alkylacrylamide, (4) vinylformamide and (5) their mixtures. Also described is the heterogeneous mixture of polymers, intended for increasing the content of a filling agent in paper or carton, obtained by the method described above. Methods of increasing the content of the filling agent in a paper or carton sheet with application of the said heterogeneous mixture of polymers are described.
EFFECT: increase of the content of an inorganic filling agent in paper with simultaneous preservation of weight, strength and suitability of the final product for processing.
17 cl, 9 tbl, 14 ex
SUBSTANCE: process is carried out in continuous mode in a polymerisation apparatus, having a polymerisation reactor which is integrated with a measuring device. The method involves feeding a low-reactivity polyester macromonomer and water into the polymerisation reactor. A portion of a highly reactive, hydrolysable monomer is then added and an aqueous polymerisation medium is formed. At least a portion of the hydrolysable monomer is initially fed into the measuring device and then into the polymerisation reactor. Free-radical polymerisation is then carried out in an aqueous medium. Before and/or while adding the hydrolysable monomer, a free-radical polymerisation initiator is fed into the polymerisation reactor. During polymerisation, the rate of adding the hydrolysable monomer and/or initiator is varied in steps or continuously. No monomer for including ionic cement binding sites into a nonionic copolymer is fed into the polymerisation reactor. The hydrolysable monomer used is at least one ethylenically unsaturated hydrolysable monomer A. The polyester macromonomer used is at least one ethylenically unsaturated monomer of polyoxyalkylene ester B and/or C. Component B and/or C can be fed into the reactor in advance and component A is then added thereto at a rate which varies at least once.
EFFECT: invention enables to obtain a nonionic copolymer which is capable of prolonging placeability of the cementing mixture over s long period of time, which enables to minimise the need to adjust deposits during preparation and at the construction site, reduce repeated dosing of plasticising additives into the cement mixture.
26 cl, 10 dwg, 9 tbl, 36 ex
SUBSTANCE: invention relates to molecularly imprinted polymers selective for at least one tobacco specific nitrosamine (TSNA), the polymer being obtained using materials comprising a TSNA or a structural analogue thereof, a neutral functional group-containing monomer selected from a group comprising 2-hydroxyethylmethacrylate (HEMA), acrylamide, methacrylamide, glycerol monoacrylate and glycerol monomethacrylate, and a hydrophobic cross-linking agent. The invention also describes a method of producing a molecularly imprinted polymer, a smoking article, a tobacco smoke filter and a kit for detecting, quantitative determination and separation of nitrosamines contained in a sample, which include a molecularly imprinted polymer, a method of reducing content of at least one TSNA in a tobacco product and a method of producing tobacco material.
EFFECT: obtaining molecularly imprinted polymers which are selective for nitroso-containing compounds.
25 cl, 18 dwg, 8 ex
SUBSTANCE: copolymer contains as monomer components, a) at least one compound which contains a sulphonic acid group, b) at least one compound selected from a group comprising N-vinyl-caprolactam, N,N-dimethylacrylamide, N,N-diethylacrylamide, isopropylacrylamide, N-vinylpyrrolidone, N-vinylacetamide, N-vinylformamide, N-methyl-N-vinylacetamide, N-alkylacrylate and N-alkylmethacrylate, and c) at least one bifunctional vinyl ester selected from: divinyl ester of triethylene glycol, divinyl ester of diethylene glycol or divinyl ester of butanediol. Also disclosed is use of the copolymer as an additive to hydraulic binders and/or compositions containing components that swell in water.
EFFECT: copolymer is sued as water-retaining or anti-segregation agent.
10 cl, 12 tbl, 20 ex
SUBSTANCE: invention relates to an aqueous polymer dispersion, a method for production thereof, use thereof and a method of making paper. The aqueous polymer dispersion for use as a flocculant when making paper or for water treatment contains an anionic water-soluble dispersion polymer which contains, in polymerised form, a monomer mixture containing (i) one or more anionic monomers, (ii) a first nonionic vinyl monomer which is an acrylamide, and (iii) at least a second nonionic vinyl monomer; a water-soluble salt and a stabiliser, where the water-soluble salt is present in an amount equal to at least 2.0 wt %, with respect to the total mass of the dispersion, and where the monomer mixture contains about 1 to about 40 mol % anionic monomer, about 20 to about 98 mol % acrylamide, and about 1 to about 40 mol % second nonionic vinyl monomer, wherein the sum of the percentage content equals 100, and the stabiliser is a polymer.
EFFECT: disclosed dispersion is characterised by better dehydration time.
23 cl, 2 tbl, 2 ex
SUBSTANCE: method of obtaining cross-linked hydrophilic polymer, demonstrating properties of superabsorbent, includes radical polymerization of acryl monomer in water medium in presence of oxidation-reduction initiating system, as acryl monomer used is N,N-dimethylacrylamide or its mixture with hydrophilic uncharged and/or ionogenic acryl monomer, polymerisation is carried out in frozen water medium, for which purpose initial solution of reagents is frozen and kept at -5…-40°C for 4…24 h, after which frozen system is thawed out, target product is separated and dried by known methods.
EFFECT: simplification of composition of initial mixture of acryl comonomers, as special linking agent is not introduced into initial solution for obtaining cross-linked polymer, invention is characterised by higher level of process safety on the whole, it is characterised by essential universality with respect to possibilities of varying water-absorbing ability of target product.
2 cl, 1 tbl, 41 ex
SUBSTANCE: disclosed is use of (meth)acrylic acid amide(s) as a comonomer (comonomers) (b), meant for enhancing thermal stability using non-formaldehyde containing aqueous dispersion of a polymer obtained via emulsion copolymerisation of at least the following components: (a) vinyl ester monomer (monomers) and (b) a comonomer (comonomers) containing said amide derivatives of acrylic and/or methacrylic acid, in the presence of at least (c) a completely hydrolysed polyvinyl alcohol (PVOH), the average degree of hydrolysis of which is more than 95.00 mol %, wherein polymerisation does not include comonomers which are amide derivatives of N-alkylol(meth)acrylic acid, and thermal stability of the adhesive compound which is measured in form of a WATT 91 value in accordance with DIN EN 14257 is higher than that of samples obtained without using amide derivatives (b) of acrylic and/or methacrylic acid. The invention also discloses a non-formaldehyde containing polymer dispersion and a method of preparing said dispersion using (meth)acrylic acid amides, as well as a binder composition containing said aqueous polymer dispersion.
EFFECT: possibility of obtaining water resistant and heat resistant wood glue which does not decolour wood when gluing.
44 cl, 8 tbl, 40 ex
SUBSTANCE: invention relates to a polymer of formula (I): In-[(A)x-(B)y-( A')x-(E)z]n, obtained via controlled free-radical polymerisation using nitroxyl radicals with excess acrylate. In is a fragment of an initiator. A and A' are identical or different monomers selected from a group comprising methylacrylate, ethylacrylate, ethylhexylacrylate, propylacrylate, cyclohexylacrylate, hydroxyethylacrylate, n-butylacrylate, styrene and vinylpyridine. The amount of unsubstituted C1-C22 alkyl acrylic esters and/or C1-C22 alkyl methacrylic esters is more than 30 wt %. B is propargylacrylate. E is a group containing at least one stable nitroxyl free radical.
EFFECT: obtaining polymers suitable for use as a wetting or dispersing agent for dyes, as well as starting material for all reactions starting with alkyne or for hydrosilylation reactions.
8 cl, 1 tbl, 3 ex
SUBSTANCE: method is realised by polymerising an aqueous solution containing 7-15 wt % acrylamide and 0.5-1.5 wt % N,N'-methylene bisacrylamide under the action of a redox system: ammonium persulphate and N;N,N',N'-tetramethyl ethylenediamine, wherein polymerisation is carried out in the presence of 0.01-0.12 wt % mercaptoacetic acid.
EFFECT: high structural homogeneity of the hydrogel.
2 tbl, 5 ex
SUBSTANCE: method is realised by polymerisation of an aqueous solution containing 7-15 wt % of acrylamide and 0.5-1.5 wt % of N,N'-methylenebisacrylamide, in presence of polymerisation initiator, besides, the polymerisation initiator is a mixture of 4,4'-azobis(4-cyanopentane acid) and ammonium salt of 4-8-dithiobenzoate of 4-cyanopentane acid with their content in the aqueous solution as 0.03-0.07 wt % and 0.07-0.35 wt %, accordingly, and polymerisation is performed at temperature of 70-80°C and pH 3.0-4.0.
EFFECT: increased structural homogeneity of a hydrogel.
2 tbl, 5 ex
SUBSTANCE: invention relates to synthesis of polymers with high water absorption based on acrylamide and can be used in production of sanitary and hygiene items, dehydrating agents for the coal industry, water-retaining agents for agriculture. Copolymerisation of an aqueous solution of monomers containing acrylamide and a crosslinking agent is carried out in the presence of ammonium persulphate as a radical copolymerisation initiator with the following ratio of components in the solution of monomers, wt %: acrylamide 85-95, guanidine methacrylate 5-15. The crosslinking agent used is guanidine methacrylate.
EFFECT: improved quality of hydrogel, reduced consumption of expensive reagents, simplification of synthesis method, improved application properties.
2 tbl, 3 dwg, 3 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to organic chemistry, namely to benzimidazole-4-carboxamide derivatives of formula , wherein X means an alkenyl group C2-C7 substituted by two methyls, nitro-radical mono-substituted thienyl, unsubstituted quinolinyl, unsubstituted indolyl, unsubstituted pyridazinyl, unsubstituted piperazinyl, C1-C6-alkyl disubstituted piperazinyl, unsubstituted piperidinyl, unsubstituted pyrazinyl, unsubstituted imidazolyl, unsubstituted pyrimidinyl, phenyl monosubstituted pyrimidinyl, pyrimidinyl disubstituted by an amine radical and a radical specified in a group containing -F, -Cl, -Br or -I, hydroxyl trisubstituted phenyl, methoxy-radical trisubstituted phenyl, hydroxyl and methoxy-radical disubstituted phenyl, pyrazolyl disubstituted by a radical specified in a group containing a C1-C6-alkyl, and by a radical specified in a group containing -F, -C1, -Br or -I; Y means aminophenyl monosubstituted by a radical of -F, -O, -Br or -I phenyl, hydroxyethyl disubstituted by hydroxymethyl or C1-C6-alkyl and phenyl monosubstituted by a nitro group, an amino group or a halogen atom; Y also means unsubstituted piperazinyl, unsubstituted pyridyl, unsubstituted pyrazinyl, C1-C6-alkyl monosubstituted thiazol, unsubstituted pyrimidinyl, unsubstituted purinyl. The invention also refers to a pharmaceutical composition based on the compound of formula (I), using the compound of formula (I), a method for producing the compound of formula (I).
EFFECT: there are prepared new benzimidazol-4-carboxamide derivatives possessing antiviral activity.
5 cl, 6 dwg, 4 tbl, 688 ex
SUBSTANCE: invention represents an oral anti-enteroviral and immunostimulant agent in the form of capsules containing interferon and additives, differing by the fact that a therapeutic substance is human recombinant interferon alpha-2b immobilised on polyethylene glycol, having a molecular weight of 1.5 kD by a physical method of binding by an accelerated electron flow in a dose of 1.5 Mrad. The ingredients in the agent are taken in a certain ratio.
EFFECT: extending the range of anti-enteroviral agents possessing immunostimulant properties.
6 ex, 10 tbl
SUBSTANCE: invention refers to medicine and concerns using rhCC10 protein for preparing a therapeutic agent for the therapeutic or preventive effect on influenza virus.
EFFECT: invention provides reducing a pulmonary titre of influenza virus.
11 cl, 4 dwg, 1 tbl, 5 ex