Ophthalmic composition

FIELD: pharmacology.

SUBSTANCE: ophthalmic composition contains a formula compound, where the values for R1 and R2 groups are given in the claims, and an ophthalmologically acceptable carrier. The invention also relates to a method for dry eye treatment, comprising local administration of a therapeutically effective amount of the ophthalmic composition to the eye of the subject in need.

EFFECT: increased efficiency.

20 cl, 6 dwg, 6 ex

 



 

Same patents:

FIELD: medicine, pharmaceutics.

SUBSTANCE: claimed invention relates to compounds of the following formula , in which n equals integer number from 1 to 15, m equals 0, 1, 2 or 3, and R represents hydrocarbon chain of polyunsaturated fatty acid, selected from omega-3 and omega-6 polyunsaturated fatty acids, and to method of obtaining them.

EFFECT: development of pharmaceutical or cosmetic composition based on said compounds and to method of acne or seborrheic dermatitis treatment for cosmetic purposes.

16 cl, 4 dwg, 2 tbl, 3 ex

FIELD: chemistry.

SUBSTANCE: invention relates to versions of a compound of formula where R1 is a hydrogen atom; R2 is a lower alkyl group; P is H; , where P1, P2 and P3 are identical or different and are selected from a hydrogen atom, a lower alkyl group and a C14-C22 alkenyl group substituted with a lower alkyl group; or where P1 is an alkenyl group, and each of P2 and P3 is a hydrogen atom; and Y is a C14-C22 alkenyl group with at least one double bond having a Z-configuration, and having a first double bond at the third carbon-carbon bond from the omega (ω)-end of the carbon chain, capable of lowering the level of triglycerides and cholesterol, a pharmaceutical or lipid composition based on the disclosed compounds, as well as use (versions) of the disclosed compounds.

EFFECT: high efficiency of using compounds.

32 cl, 6 dwg

FIELD: chemistry.

SUBSTANCE: invention relates to novel omega-3 lipid compounds of general formula (I) or to their pharmaceutically acceptable salt, where in formula (I): R1 and R2 are similar or different and can be selected from group of substitutes, consisting of hydrogen atom, hydroxy group, C1-C7alkyl group, halogen atom, C1-C7alkoxy group, C1-C7alkylthio group, C1-C7alkoxycarbonyl group, carboxy group, aminogroup and C1-C7alkylamino group; X represents carboxylic acid or its carbonate, selected from ethylcarboxylate, methylcarboxylate, n-propylcarboxylate, isopropylcarboxylate, n-butylcarboxylate, sec-butylcarboxylate or n-hexylcarboxylate, carboxylic acid in form of triglyceride, diglyceride, 1-monoglyceride or 2-monoglyceride, or carboxamide, selected from primary carboxamide, N-methylcarboxamide, N,N-dimethylcarboxamide, N-ethylcarboxamide or N,N-diethylcarboxamide; and Y stands for C16-C22 alkene with two or more double bonds, which have E- and/or Z-configuration.

EFFECT: described are pharmaceutical and lipid compositions, which contain said compounds, for application as medications, in particular, for treatment and/or prevention of peripheral insulin resistance and/or condition of diabetes, for instance, type 2 diabetes, increased levels of triglycerides and/or levels of non-HDL cholesterol, LDL cholesterol and VLDL cholesterol, hyperlipidemic condition, for instance, hypertriglyceridemia (HTG), obesity or condition of excessive body weight, fatty liver disease, for instance, non-alcoholic fatty liver disease (NAFLD) or inflammatory disease or condition.

60 cl, 3 tbl, 65 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to a new lipid compound of general formula , wherein n=0; R1 and R2 are identical or different, and may be specified in a group of substitutes consisting of a hydrogen atom, a C1-C7alkyl group, a halogen atom and a C1-C7alkoxy group; X represents COR3 or CH2OR4, wherein R3 is specified in a group consisting of hydrogen, hydroxy, C1-C7alkoxy and amino; and R4 is specified in a group consisting of hydrogen, C1-C7alkyl or C1-C7acyl, Y represents C9-C21 alkene with one or more double bonds in E- or Z-configurations with the chain Y being unsubstituted and containing a double bond in the ω-3 position; provided R1 and R2 cannot simultaneously represent a hydrogen atom.

EFFECT: invention refers to pharmaceutical compositions containing the lipid compounds which are used for treating and/or preventing the conditions related to high NFkB functions, treating and/or preventing an inflammatory disease or a condition, lower plasma insulin and/or blood glucose levels, treating insulin resistance, treating and/or preventing peripheral tissue insulin resistance and/or diabetic condition, eg type 2 diabetes mellitus.

45 cl, 1 tbl, 1 dwg, 31 ex

FIELD: medicine.

SUBSTANCE: invention refers to new compounds of formula (I) where X is carboxylic acid, carboxylates, carboxylic anhydride, diglyceride, triglyceride, phospholipid, or carboxamides, or to any their pharmaceutically acceptable salt. The invention particularly refers to (4Z, 7Z, 10Z, 13Z, 16Z, 19Z)-ethyl 2-ethyldocosa-4,7,10,13,16,19-hexanoate. The invention also refers to a food lipid composition and to a composition for diabetes, for reducing insulin, blood glucose, plasma triglyceride, for dislipidemia, for reducing blood cholesterol, body weight and for peripheral insulin resistance, including such compounds. Besides, the invention refers to methods for treating and/or preventing diabetes, dislipidemia, peripheral insulin resistance, body weight reduction and/or weight gain prevention, insulin, blood cholesterol, blood glucose and/or plasma triglyceride reduction.

EFFECT: higher clinical effectiveness.

61 cl, 4 tbl, 16 dwg, 5 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to application of compounds with formula R2=R1-X, where R1 and R2 have 23 to 35 carbon atoms in sum, X represents primary alcohol functional group -CH2OH or carboxyl group -COOH, R1 is saturated linear hydrocarbon chain with 9 carbon atoms, and R2 is linear hydrocarbon chain, which is saturated or unsaturated, including 1 to 4 unsaturated double links.

EFFECT: producing formulations suited for application to hypercholesterolemia therapy and prophylaxis.

3 cl, 4 tbl, 6 ex

FIELD: organic chemistry, labeled compounds.

SUBSTANCE: invention relates to new tritium-labeled 2-arachidonoyl-[1,3-3H]-glycerol of the formula: CH3-(CH2)4-(CH=CHCH2)4-(CH2)2-COOCH-(C3HHOH)2 able to bind and activate cannabinoid receptors. This compound can be used in analytical, bioorganic chemistry, biochemistry and applied medicine.

EFFECT: valuable properties of compound.

1 ex

The invention relates to new compounds with the structure associated 1,3-propane diol, having the ability to penetrate lipid barriers, formula 1, where R1denotes an acyl group or a group of fatty alcohol, derived from C12-30preferably C16-30the fatty acids preferably with two or more double bonds in the CIS - or TRANS-position, and R2denotes hydrogen, acyl group or the group of fatty alcohol, which is the same or different from that specified for R1or is a biologically active residue that is different from the rest of Niacin, the chemical structure of which allows you to connect with 1,3-propane diol through the available carboxyl, alcohol or amino group

The invention relates to organic chemistry, in particular, to a method for producing 2,6-dimethyl-10-methylene-4-C1-C4arcoxia - bonil-2,6,11-dodecatrien

FIELD: food industry.

SUBSTANCE: composition is concentrated in terms of compound ethers of pinosylvine and produced by way of crude tall oil distillation or evaporation; the compound ethers acidic residue is formed by linoleic, linolenic, oleic acid or tricyclic, aliphatic or aromatic carboxylic acid. Stilbenes are extracted from the crude tall oil distillation or evaporation fraction containing stilbenes compound ethers; the fraction is concentrated. Then the stilbenes compound ethers are modified into the desired stilbenes by way of stilbenes compound ethers separation from their compound ether group. The crude tall oil distillation or evaporation fractions contain pinosylvine or its compound ethers in an amount of 5 - 95 % of the total weight of the composition.

EFFECT: invention relates to fat-and-oil industry, in particular, to a composition suitable for stilbenes production, to its production method, to a method for extraction of stilbenes from crude tall oil, to a compound ether of resin acid and pinosylvine or to its simple monomethyl ether.

26 cl, 1 dwg, 3 ex

FIELD: chemistry.

SUBSTANCE: method of obtaining diphenylcarbonate includes a reaction of carbon dioxide and epoxide in the first reaction zone with the formation of the first reaction product, which includes cyclic carbonate; reetherification of cyclic carbonate with ethanol in the presence of a catalyst of the first reetherification in the second reaction zone with the formation of the second reaction product, which includes diethylcarbonate and glycol; separation of the second reaction product with the extraction of the first fraction of diethylcarbonate and the first fraction of glycol; reetherification of, at least, a part of the first fraction of diethylcarbonate with arylhydroxycompound in the presence of a catalyst of the second reetherification in the third reaction zone with the formation of the third reaction product, which includes ethylarylcarbonate and ethanol; separation of the third reaction product with the extraction of ethylarylcarbonate fraction and the first fraction of ethanol; disproportioning of, at least, a part of ethylarylcarbonate fraction in the presence of a catalyst of disproportioning in the fourth reaction zone with the formation of the fourth reaction product, which includes diarylcarbonate and diethylcarbonate; separation of the fourth reaction product with the extraction of diarylcarbonate fraction and the second diethylcarbonate fraction; recirculation of, at least, a part of the first ethanol fraction into the second reaction zone and recirculation of, at least, a part of the second diethylcarbonate fraction into the third reaction zone. Or a method of diarylcarbonate obtaining includes a reaction of ammonia and carbon dioxide in the first reaction zone with the formation of the first reaction product, which includes urea; reetherification of urea with ethanol in the presence of a catalyst of the first reetherification in the second reaction zone with the formation of the second reaction product, which includes diethylcarbonate and ammonia; separation of the second reaction product with the extraction of the first fraction of diethylcarbonate and the first fraction of ammonia; reethrification of, at least, a part of the first fraction of diethylcarbonate with arylhydroxycompound in the presence of a catalyst of the second reetherification in the third reaction zone with the formation of the third reaction product, which includes ethylarylcarbonate and ethanol; separation of the third reaction product with the extraction of the ethylarylcarbonate fraction and ethanol fraction; disproportioning of, at least, part of the ethylarylcarbonate fraction in the presence of a catalyst of disproportioning in the fourth reaction zone with the formation of the fourth reaction product, which includes diarylcarbonate and diethylcarbonate; separation of the fourth reaction product with the extraction of the diarylcarbonate fraction and the second fraction of diethylcarbonate; recirculation of, at least, a part of the ethanol fraction into the second reaction zone and recirculation of, at least, a part of the second diethylcarbonate fraction into the third reaction zone. Disclosed methods efficiently combine into one the whole production of diethylcarbonate and diarylcarbonate, eliminating the necessity of extraction distillation with a solvent, which is usually applied in the production of diarylcarbonates from dimethylcabonate, providing a combination of reaction and separation equipment and best use of the raw material and reducing production costs and capital investments for such methods. In some versions of realisation the methods disclosed in the invention can be realised, for instance, with a practically closed cycle for ethanol.

EFFECT: invention relates to the methods of obtaining diarylcarbonates, which make it possible to obtain diarylcarbonates from gases, causing the greenhouse effect, such as carbon dioxide.

29 cl, 24 dwg, 9 tbl, 18 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: claimed invention relates to compounds of the following formula , in which n equals integer number from 1 to 15, m equals 0, 1, 2 or 3, and R represents hydrocarbon chain of polyunsaturated fatty acid, selected from omega-3 and omega-6 polyunsaturated fatty acids, and to method of obtaining them.

EFFECT: development of pharmaceutical or cosmetic composition based on said compounds and to method of acne or seborrheic dermatitis treatment for cosmetic purposes.

16 cl, 4 dwg, 2 tbl, 3 ex

FIELD: chemistry.

SUBSTANCE: invention relates to versions of a compound of formula where R1 is a hydrogen atom; R2 is a lower alkyl group; P is H; , where P1, P2 and P3 are identical or different and are selected from a hydrogen atom, a lower alkyl group and a C14-C22 alkenyl group substituted with a lower alkyl group; or where P1 is an alkenyl group, and each of P2 and P3 is a hydrogen atom; and Y is a C14-C22 alkenyl group with at least one double bond having a Z-configuration, and having a first double bond at the third carbon-carbon bond from the omega (ω)-end of the carbon chain, capable of lowering the level of triglycerides and cholesterol, a pharmaceutical or lipid composition based on the disclosed compounds, as well as use (versions) of the disclosed compounds.

EFFECT: high efficiency of using compounds.

32 cl, 6 dwg

FIELD: chemistry.

SUBSTANCE: invention relates to novel omega-3 lipid compounds of general formula (I) or to their pharmaceutically acceptable salt, where in formula (I): R1 and R2 are similar or different and can be selected from group of substitutes, consisting of hydrogen atom, hydroxy group, C1-C7alkyl group, halogen atom, C1-C7alkoxy group, C1-C7alkylthio group, C1-C7alkoxycarbonyl group, carboxy group, aminogroup and C1-C7alkylamino group; X represents carboxylic acid or its carbonate, selected from ethylcarboxylate, methylcarboxylate, n-propylcarboxylate, isopropylcarboxylate, n-butylcarboxylate, sec-butylcarboxylate or n-hexylcarboxylate, carboxylic acid in form of triglyceride, diglyceride, 1-monoglyceride or 2-monoglyceride, or carboxamide, selected from primary carboxamide, N-methylcarboxamide, N,N-dimethylcarboxamide, N-ethylcarboxamide or N,N-diethylcarboxamide; and Y stands for C16-C22 alkene with two or more double bonds, which have E- and/or Z-configuration.

EFFECT: described are pharmaceutical and lipid compositions, which contain said compounds, for application as medications, in particular, for treatment and/or prevention of peripheral insulin resistance and/or condition of diabetes, for instance, type 2 diabetes, increased levels of triglycerides and/or levels of non-HDL cholesterol, LDL cholesterol and VLDL cholesterol, hyperlipidemic condition, for instance, hypertriglyceridemia (HTG), obesity or condition of excessive body weight, fatty liver disease, for instance, non-alcoholic fatty liver disease (NAFLD) or inflammatory disease or condition.

60 cl, 3 tbl, 65 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to a new lipid compound of general formula , wherein n=0; R1 and R2 are identical or different, and may be specified in a group of substitutes consisting of a hydrogen atom, a C1-C7alkyl group, a halogen atom and a C1-C7alkoxy group; X represents COR3 or CH2OR4, wherein R3 is specified in a group consisting of hydrogen, hydroxy, C1-C7alkoxy and amino; and R4 is specified in a group consisting of hydrogen, C1-C7alkyl or C1-C7acyl, Y represents C9-C21 alkene with one or more double bonds in E- or Z-configurations with the chain Y being unsubstituted and containing a double bond in the ω-3 position; provided R1 and R2 cannot simultaneously represent a hydrogen atom.

EFFECT: invention refers to pharmaceutical compositions containing the lipid compounds which are used for treating and/or preventing the conditions related to high NFkB functions, treating and/or preventing an inflammatory disease or a condition, lower plasma insulin and/or blood glucose levels, treating insulin resistance, treating and/or preventing peripheral tissue insulin resistance and/or diabetic condition, eg type 2 diabetes mellitus.

45 cl, 1 tbl, 1 dwg, 31 ex

FIELD: medicine.

SUBSTANCE: invention refers to new compounds of formula (I) where X is carboxylic acid, carboxylates, carboxylic anhydride, diglyceride, triglyceride, phospholipid, or carboxamides, or to any their pharmaceutically acceptable salt. The invention particularly refers to (4Z, 7Z, 10Z, 13Z, 16Z, 19Z)-ethyl 2-ethyldocosa-4,7,10,13,16,19-hexanoate. The invention also refers to a food lipid composition and to a composition for diabetes, for reducing insulin, blood glucose, plasma triglyceride, for dislipidemia, for reducing blood cholesterol, body weight and for peripheral insulin resistance, including such compounds. Besides, the invention refers to methods for treating and/or preventing diabetes, dislipidemia, peripheral insulin resistance, body weight reduction and/or weight gain prevention, insulin, blood cholesterol, blood glucose and/or plasma triglyceride reduction.

EFFECT: higher clinical effectiveness.

61 cl, 4 tbl, 16 dwg, 5 ex

FIELD: chemistry.

SUBSTANCE: invention relates to a product used in chocolate, margarine or shortening, obtained by melting a mixture of components (a) and (b), where component (a) contains triglyceride of disaturated medium-chain fatty acids and monosaturated long-chain fatty acid and (b) contains triglyceride of 1,3-disaturated long-chain fattya cids and 2-monosaturated long-chain fatty acid, wherein the bond length determined through X-ray diffraction, measured in the product is equal to greater than 65 Å, where the medium-chain fatty acid(s) contain(s) 6-12 carbon atoms, and the long-chain fatty acid(s) contain(s) 14-24 carbon atoms.

EFFECT: owing to formation of intramolecular compounds, fats and oil contain a larger amount of symmetrical triglycerides such as cocoa oil, and contain medium-chain fatty acids which do not form separate crystals and can endow the product with a smooth texture and prevent turbidity.

8 cl, 9 dwg, 17 tbl, 6 ex

FIELD: chemistry.

SUBSTANCE: invention relates to an improved method of producing carboxylic esters via esterification of carboxylic acids and/or re-esterification of carboxylic esters with methanol or ethanol in the presence of a metallic catalyst, in which the reaction takes place at temperature higher than 150°C, said metallic catalyst is an alkali-earth metal salt and an aliphatic carboxylic acid containing 10-24 carbon atoms, and at the end of esterification or re-esterification, respectively, the metallic catalyst is extracted and then reused as a liquid catalyst in the method of producing carboxylic esters via esterification of carboxylic acids and/or re-esterification of carboxylic esters with methanol or ethanol in the presence of a catalyst. The advantage of the method lies in that, in the initial mixture, free fatty acids can be present in any concentrations. These free fatty acids are also esterified in the said reaction to fatty acid alkyl esters. Hence, low-quality fat/oil can be processed. Another advantage of the method is that, the esterification/re-esterification reaction can also take place in the presence of water. Thus, water-containing material, particularly hydrous alcohol, can also be used. Unreacted free fatty acids or glycerides are returned for esterification/re-esterification, owing to which no losses occur. In contrast to processes without catalysts, the disclosed method has an advantage in that, the reaction can take place with amounts of alcohol which are a little higher than stoichiometric amounts, which markedly increases profitability of the method.

EFFECT: improved method of producing carboxylic esters.

5 cl, 4 tbl, 3 ex

FIELD: chemistry.

SUBSTANCE: raw material composition based on fatty acids or esters of fatty acids, obtained by hydrolysis of oil from seeds or by re-etherification of oil from seeds with C1-8-alkanol, contains more than 70 wt % of unsaturated fatty oleic acid, and less than 1.5 milliequivalents of admixture(s), poisoning methathesis catalyst, per kilogram of composition, after purification with adsorbent. Admixture contains one or more organic hydroperoxides. Method of olefin methathesis lies in contacting of raw composition, obtained from seed oil and containing one or more unsaturated fatty acids or esters of unsaturated fatty acids, with lower olefin in presence of catalyst based on phosphororganic transition metal complex. Used raw material composition contains less than 25 milliequivalents of admixture(s), poisoning methathesis catalyst, per kilogram of raw material composition, able to inhibit methathesis catalyst. As a result of reaction olefin with shortened chain and unsaturated acid or unsaturated ester with shortened chain is obtained. Method of obtaining complex polyether polyepoxide lies in carrying out the following stages. At the first stage raw material compositiojn, obtained from seed oil, containing one or more unsaturated fatty acids or esters of fatty acids, contacts with lower olefin in presence of olefin methathesis catalyst. Used raw material composition contains less than 25 milliequivalents of admixture(s), poisoning methathesis catalyst, per kilogram of composition. At the second stage (re)etherification of obtained unsaturated acid with shortened chain or unsaturated ester with shortened chain with polyol is carried out. At the third stage epoxidation of obtained complex polyether polyolefin is carried out with epoxidising agent optionally in presence of catalyst. Method of obtaining α,ω-oxoacid, complex α,ω-oxyester and/or α,ω-diol with shortened chain lies in carrying out the following stages. At the first stage raw material composition, obtained from seed oil, containing one or more unsaturated fatty acids or esters of fatty acids contacts with lower olefin in presence of olefin methathesis catalyst. Used raw material composition contains less than 25 milliequivalents of admixture(s), poisoning methathesis catalyst, per kilogram of composition. At the second stage hydroformilation is carried out with hydrating of obtained unsaturated acid or ester with shortened chain in presence of hydroformiolation/hydration catalyst.

EFFECT: increase of catalyst serviceability and obtaining chemical compounds with high productivity.

25 cl, 3 tbl, 12 ex

FIELD: chemistry.

SUBSTANCE: invention relates to methods of obtaining esters of amyl alcohols and simplest carboxylic acids C1-C4. Alcohol-containing wastes of caprolactam production are used as raw material. Method includes etherification of alcohol-containing wastes of caprolactam wastes with simplest carboxylic acids C1-C4 in presence of acidic catalyst. Process of etherification is carried out with continuous azeotropic distillation of water with reaction mixture components, as catalyst, sulfuric or orthophosphoric acid is used, catalyst is loaded in amount 0.1-2.5% of the total weight of initial substances, reaction mixture is cooled to 20-30°C and neutralised with water-alkaline solution with mixing to water layer pH 7-8, water phase is separated, organic phase is washed one-two times with water, final purification of esters is carried out by fractional distillation of organic phase. Obtained products are suitable for application as solvents for paints and varnishes, raw material for organic synthesis, as component of complex fuel additives.

EFFECT: obtaining esters of amyl alcohols and simplest carboxylic acids C1-C4, characterised by high purity without catalyst admixtures, low water content - not more than 0,1%, and residual organic acids - not more than 0,01 without application of secondary rectification, as absence of acid facilitates purification of esters.

9 ex

FIELD: chemistry.

SUBSTANCE: method of obtaining diphenylcarbonate includes a reaction of carbon dioxide and epoxide in the first reaction zone with the formation of the first reaction product, which includes cyclic carbonate; reetherification of cyclic carbonate with ethanol in the presence of a catalyst of the first reetherification in the second reaction zone with the formation of the second reaction product, which includes diethylcarbonate and glycol; separation of the second reaction product with the extraction of the first fraction of diethylcarbonate and the first fraction of glycol; reetherification of, at least, a part of the first fraction of diethylcarbonate with arylhydroxycompound in the presence of a catalyst of the second reetherification in the third reaction zone with the formation of the third reaction product, which includes ethylarylcarbonate and ethanol; separation of the third reaction product with the extraction of ethylarylcarbonate fraction and the first fraction of ethanol; disproportioning of, at least, a part of ethylarylcarbonate fraction in the presence of a catalyst of disproportioning in the fourth reaction zone with the formation of the fourth reaction product, which includes diarylcarbonate and diethylcarbonate; separation of the fourth reaction product with the extraction of diarylcarbonate fraction and the second diethylcarbonate fraction; recirculation of, at least, a part of the first ethanol fraction into the second reaction zone and recirculation of, at least, a part of the second diethylcarbonate fraction into the third reaction zone. Or a method of diarylcarbonate obtaining includes a reaction of ammonia and carbon dioxide in the first reaction zone with the formation of the first reaction product, which includes urea; reetherification of urea with ethanol in the presence of a catalyst of the first reetherification in the second reaction zone with the formation of the second reaction product, which includes diethylcarbonate and ammonia; separation of the second reaction product with the extraction of the first fraction of diethylcarbonate and the first fraction of ammonia; reethrification of, at least, a part of the first fraction of diethylcarbonate with arylhydroxycompound in the presence of a catalyst of the second reetherification in the third reaction zone with the formation of the third reaction product, which includes ethylarylcarbonate and ethanol; separation of the third reaction product with the extraction of the ethylarylcarbonate fraction and ethanol fraction; disproportioning of, at least, part of the ethylarylcarbonate fraction in the presence of a catalyst of disproportioning in the fourth reaction zone with the formation of the fourth reaction product, which includes diarylcarbonate and diethylcarbonate; separation of the fourth reaction product with the extraction of the diarylcarbonate fraction and the second fraction of diethylcarbonate; recirculation of, at least, a part of the ethanol fraction into the second reaction zone and recirculation of, at least, a part of the second diethylcarbonate fraction into the third reaction zone. Disclosed methods efficiently combine into one the whole production of diethylcarbonate and diarylcarbonate, eliminating the necessity of extraction distillation with a solvent, which is usually applied in the production of diarylcarbonates from dimethylcabonate, providing a combination of reaction and separation equipment and best use of the raw material and reducing production costs and capital investments for such methods. In some versions of realisation the methods disclosed in the invention can be realised, for instance, with a practically closed cycle for ethanol.

EFFECT: invention relates to the methods of obtaining diarylcarbonates, which make it possible to obtain diarylcarbonates from gases, causing the greenhouse effect, such as carbon dioxide.

29 cl, 24 dwg, 9 tbl, 18 ex

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