Agents with diuretic activity

FIELD: pharmacology.

SUBSTANCE: diuretic contains 0.5% solution of humic acids and magnesium chloride, taken in a certain ratio.

EFFECT: means allows to increase therapy effectiveness and eliminates occurrence of side effects.

3 ex

 



 

Same patents:

FIELD: medicine.

SUBSTANCE: invention represents a composition for surgical area infiltration in liposuction or lymphedema elimination, containing normal saline, 0.5% Naropin and phosphatidylcholine in ratio 9:1:6 respectively per 10-15 cm3 fat.

EFFECT: reducing oedema, tissue injuries and blood loss volume, preventing microcirculation disorders in soft tissues and complications, reducing a risk of recurrences and promoting a faster rehabilitation of the patients.

2 cl

FIELD: chemistry.

SUBSTANCE: invention relates to 4-hydroxy-N-(2-carboxyphenyl)-1-methyl-2,2-dioxo-1H-2λ6 ,1-benzothiazine-3-carboxamide, which possesses diuretic activity.

EFFECT: obtained is novel compound, possessing useful biological activity.

1 tbl, 3 ex

FIELD: biotechnology.

SUBSTANCE: agent is proposed which has diuretic and anti-inflammatory action. It is shown that the sodium salt of 4-carboxyphenyl-O-β-D-glucopyranoside increased the daily diuresis 2 times or more, at that the excretion of sodium and potassium ions is reduced compared to the control; its anti-inflammatory activity is slightly higher than that of nimesulide. Due to the combination of the diuretic effect with anti-inflammatory and antimicrobial activities the agent can be used for the treatment of nephritis, pyelonephritis, cystitis of stagnant phenomena in the systemic and pulmonary circulation due to heart failure.

EFFECT: increased water excretion thus contributing to reduction of swelling.

2 tbl

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to pharmaceutics, namely to application of P-methyl-phenyl-O-D-glucopyranoside as medication, which has a diuretic action, which has high diuretic and low saluretic activity.

EFFECT: obtaining medication, which has a diuretic action, which has high diuretic and low saluretic activity.

1 tbl, 1 ex

Diuretic agent // 2500407

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to pharmacology, namely to using "П"-methyl-phenyl-O-D-glucopyranoside as an agent possessing high diuretic and low saluretic activity.

EFFECT: preparing the diuretic drug possessing high diuretic and low saluretic activity.

1 tbl, 1 ex

FIELD: biotechnologies.

SUBSTANCE: peptide of the formula H-(N-Me)-Arg-Lys-Lys-Tyr-Lys-Tyr-Arg-D-Arg-Lys-NH2 is proposed. The proposed peptide may find application as an agent for reduction of pathological hyperpermeability of vessel endothelium in various areas of medicine (in cardiology, toxicology, neurosurgery, oncology, etc.).

EFFECT: prevention of sharp increase of vessel endothelium permeability when injected to a recipient.

3 cl, 4 dwg, 1 tbl, 5 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to pharmaceutical industry and deals with creation of medication of vegetable origin based on biologically active substances of Linaria vulgaris, which has diuretic and anticoagulation activity. Method of obtaining medication, which has diuretic and anticoagulation activity, consists in the following: extraction of milled grass of Linaria vulgaris with ethyl alcohol is carried out with successive drawing with 3 parts of extractant by method of remaceration with heating and connecting vacuum at the stage of discharge, under specified conditions.

EFFECT: method makes it possible to obtain medication, which has high diuretic and anticoagulation activity.

3 tbl, 1 ex

Diuretic agent // 2487714

FIELD: medicine, pharmaceutics.

SUBSTANCE: what is presented is an agent of diuretic action of a group of aquaretics, phenyl-α-O-D- glucopyranoside. The agent may be used both to treat greater and lesser circulation congestions caused by cardiac failure, and to intensify water release thereby helping to reduce oedemas. The agent has high and low saluretic activity unlike the existing diuretics and expands the range of products of synthetic origin possessing diuretic activity.

EFFECT: agent is applicable for treating the number of cardiovascular diseases accompanied by excessive hydration and developing oedema syndrome.

1 tbl

Diuretic agent // 2484826

FIELD: medicine, pharmaceutics.

SUBSTANCE: what is presented is a diuretic of the aquaretic group that is 4-nitro-phenyl-O-D-glucopyranoside. The agent may be used both to treat greater and lesser circulation congestions caused by cardiac failure, and to intensify water release thereby helping to reduce oedemas. The diuretic agent has high and low saluretic activity unlike the existing diuretics and expands the range of products of synthetic origin possessing diuretic activity.

EFFECT: agent is applicable for treating a number of cardiovascular diseases accompanied by excessive hydration and developing oedema syndrome.

1 tbl

FIELD: medicine.

SUBSTANCE: what is described is a new pharmaceutically solid preparation of a vasopressin antagonist which contains: (a) 7-chlor-5-hydroxy-1-[2-methyl-4-(2-methylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro- 1H-benzoazepine and/or its salt; (b) hydroxypropylcellulose containing a hydroxypropoxyl group in the amount of 50% or more; and (c) at least one of the ingredients specified in a group consisting of carmellose, sodium carboxymethyl starch, crospovidone and hydroxypropylcellulose with a lower degree of substitution with an average diameter of particles 30 to 70 mcm and 90% of the cumulative diameter of 100 to 200 mcm.

EFFECT: pharmaceutical solid preparation shows excellent desintegration properties and solubility leading to adequate gastrointestinal absorbability of the active ingredients.

17 cl, 4 tbl, 21 ex

FIELD: veterinary medicine.

SUBSTANCE: agent comprises enrofloxacin and excipients. The agent additionally comprises humates of peat or sapropel, with the following ratio of the components, wt %: enrofloxacin substance - 0.5; alkaline solution of humates (pH=12-13) - 80; succinic acid - to pH 10-11; propylene glycol - the rest. The agent is administered with the liquid feed once a day for three to five days at a dose of from 0.5 to 1.0 ml per 1 kg of body weight.

EFFECT: manifestation of pronounced therapeutic effect.

5 tbl, 2 ex

FIELD: medicine.

SUBSTANCE: erythrocyte cell medium is added with an aqueous solution of sodium and potassium salts of humic acids prepared on brown coal of leonardite in a dose of 10.0 mg/kg. That is incubated at a temperature of 37°C for 40 minutes before treatment with acidic haemolytic.

EFFECT: invention enables normalising the cell membrane permeability and reducing the damaged cell count under acidic haemolytic.

1 tbl

FIELD: medicine.

SUBSTANCE: method involves doing therapeutic exercises and pulsed ultrasonic therapy at a pulse length of 10 ms. That is combined with the magnetic stimulation of the shoulder girdle muscles: m. trapezius m. deltoideus, m. supraspinatus, m. infraspinatus on the involved side. That involves the exposure in accordance with a stable technique with using paired pulses of the length of 220±20 mcs at a pulse repetition frequency of 25±5 pulse/min and a pulse-to-pulse spacing of 80 ms for 3 min per one field. The exposure intensity is 70-90% of the maximum magnetic induction amplitude 1,300 mT. The total length of the procedure is 12 minutes. Then 30 minutes later, mud therapy is conducted by applications on the involved shoulder joint. A mud cake temperature makes 38-40 degrees, and the length of the exposure makes 20 minutes. The mud therapy is followed by ultrasonic therapy. The exposure covers the rotator cuff and attachment points of the tendons - m. supraspinatus, m. infraspinatus, m. teres minor on the involved side. The exposure follows a labile technique at an intensity of 0.2-0.4 W/cm2 for 2 minutes per each field at the total length of the procedure of 8 minutes. The procedures are daily. The therapeutic course is 8-10 procedures.

EFFECT: method enables clinical effectiveness by recovering the motor activity of the involved extremity and prolongs the remission, prevents the progression of the biomechanical and neurodystrophic disorders, and formation of neurological complications.

1 ex, 4 tbl, 1 dwg

FIELD: medicine.

SUBSTANCE: invention refers to medicine, particularly to experimental balneology, and concerns a method for preparing concentrated sapropel. A method for preparing concentrated sapropel, involving recovering and concentrating easily disaggregating water-soluble components of sapropel by placing native sapropelinto a vacuum evaporator, which is exhausted and heated; a heating procedure is combined with exposing to ultrasound with measuring an ultrasound rate continuously or intermittently and accelerating ultrasound by differentiating the ultrasound rate on time; the above measurement procedure is repeated until the ultrasound acceleration gets equal to zero; the procedure of recovering the easily disaggregating water-soluble components of sapropel and the concentration procedure is terminated, and a dry residue is solubilised in the concentrated easily disaggregating water-soluble components in certain circumstances.

EFFECT: method enables reducing the time of concentrated sapropel production and improving the product quality.

1 dwg, 1 ex

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to balneology. A balneological agent for treating and preventing various diseases is prepared by the gradual and sequential mixing at room temperature of yellow clay, natural brine of Bolshoy Tambukan Lake, sage essence, dimethyl sulphoxide in certain relations.

EFFECT: agent possesses the more prominent therapeutic effect.

5 tbl, 2 ex

FIELD: chemistry.

SUBSTANCE: application of 5% water solution of sodium and potassium salts of humic acids, obtained from leonardite brown coal, in dose 10.0 mg/kg as membrane-protective preparation.

EFFECT: application of composition described above makes it possible to extend arsenal of membrane-protective preparations from low-toxic, cheap, available natural raw material.

2 dwg, 2 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: claimed invention relates to the field of medicine, namely to pharmacology, and describes a composition, containing fulvic acid or its salt and an antifungal compound, selected from fluconazole and amphotericin B. In accordance with the first version of the implementation the composition contains about 10 ml/kg of a solution of from about 0.25% to about 1% (wt/vol) fulvic acid or its salt and of about 10 mg/kg fluconazole. In accordance with the second version of the implementation the composition contains 0.25% (wt/vol) of the solution of fulvic acid or its salt and from about 0.06 mg/l to about 0.5 mg/l of amphotericin B.

EFFECT: invention can be used in a method of treating a fungal infection of the human or animal body, the method includes the introduction to an object, requiring it, of a therapeutically effective quantity of the composition.

11 cl, 1 dwg, 10 tbl, 3 ex

FIELD: chemistry.

SUBSTANCE: method of obtaining a sapropel concentrate includes the extraction of easily separable water-soluble components of a native sapropel by the centrifugation and separation of a supernatant, with the supernatant being discharged into a vacuum evaporating aggregate, in which the concentration of the claimed supernatant is realised by the evaporation in vacuum, and the sapropel sediment is placed in a drying chamber, separated from the vacuum chamber with a net and a hermetic lock, heated with the simultaneous creation of a vacuum in the vacuum chamber, after which the sapropel sediment is subjected to a vacuum-impulse influence, the remaining moisture separated from the sediment is pumped by a vacuum pump into the vacuum evaporating aggregate, where it is condensed and concentrated at the same modes as the supernatant, after that, the dry sediment (extraction cake) is milled and packed, and the obtained concentrate is poured into vessels and each of the obtained target products is applied by purpose or the solubilisation of the milled dry sediment (extraction cake) is realised in the obtained concentrate of easily separable water-soluble components under certain conditions.

EFFECT: method makes it possible to preserve all useful substances of the native sapropel.

1 dwg

FIELD: chemistry.

SUBSTANCE: peat in a mixture with water is loaded into a dispersion chamber, then the dispersion chamber is pressurised, static pressure of 5-7 atm is supplied into it and the content of the chamber is processed by ultrasonic vibrations with a density of insonification not less than 50 W/cm2, providing the sound pressure on the mixture of peat with water for the preliminarily specified time, which exceeds the static pressure by 2-3 times. The invention also relates to biogel, obtained by the claimed method.

EFFECT: obtaining water-peat biogel with nanosized particles, in which useful substances do not lose their efficiency.

4 cl

FIELD: medicine.

SUBSTANCE: method for preparing an agent showing anti-inflammatory action involves an alkali treatment of terrestrial peat and extraction in the alcohol-chloroform mixture. The terrestrial peat preliminarily ground and dried is milled in the AGO planetary activator before the extraction in the presence of solid alkali and sodium percarbonate for 1 min.

EFFECT: method enables higher antioxidant and anti-inflammatory activity of the terrestrial peat agent by increasing a yield of the extractive biologically active substances.

3 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to veterinary and can be applied in pig-breeding for the stimulation of exchange processes, growth activity, prevention of hypomicroelementosis and diarrhoeas of piglets. An energometabolic composition for the stimulation of exchange processes represents a water solution, which contains succinic acid, iodinol, beet molasses and sulphates of iron, copper, cobalt, zinc, with the following component content in 1000 ml of the solution: succinic acid - 10.0 g, iodinol - 250 ml, beet molasses - 300 ml, iron sulphate - 2 g, copper sulphate - 0.1 g, cobalt sulphate - 1 g, zinc sulphate - 0.3 g, water- the remaining part.

EFFECT: application of the invention will make it possible to improve exchange processes in piglets.

4 tbl

Up!