Method for preventing inflammatory complications in patients accompanying outpatient oral surgeries

FIELD: medicine.

SUBSTANCE: 5-6 days before surgery, 0.15% Tantum Verde mouth wash solution is prescribed daily two times a day in a dose of 15 ml, and postoperatively the patient is supposed to take 2-3-minute oral baths of the same 3-4 times a day for 5-7 days. The postoperative care also implies 5-7 sessions of intraoral anode electrophoresis with 10% Dimexidum on the surgical area.

EFFECT: method enables providing the more effective prevention of inflammatory complications.

3 ex

 

The invention relates to medicine, namely to dentistry, and can be used for the prevention of inflammatory complications in patients with outpatient surgical procedures in the oral cavity in the perioperative period.

The known method of prevention of postoperative inflammatory complications in patients using systemic administration of antibiotics prior to surgery and topical use after surgery dental adhesive films "diplen-dent" that contains lincomycin antibiotics and metronidazole (Tsarev V. N., Ushakov R. V. antimicrobial therapy in dentistry: a Guide. - M: Medical information Agency. - 2004. - P. 59-65).

The disadvantages of this method is the lack of a local anti-inflammatory, analgesic and immunotropic effect.

The prototype of the claimed proposal is the use of the drug "Tantum Verde" for the prevention of inflammatory complications in patients with outpatient surgical procedures in the oral cavity.

In dentistry on the recommendation of the manufacturer of the drug "Tantum Verde" is used in the form of 0.15% mouthwash, tablets (3 mg benzydamine in 1 tablet) for dissolution and spray after surgery and trauma (tooth extraction, jaw fracture, etc.) for the treatment and prevention of vospalitel�x of periodontal disease and the mucous membranes of the oral cavity (instructions for medical use of the drug "Tantum Verde" (registration number: P # 014279/03-a solution for local use)-JSC "CSC co., LTD.- Moscow).

The disadvantages of the prototype: low efficiency due to the lack of immunotropic effect and a short-acting drug.

The technical result: improving the efficiency of prevention of inflammatory complications in patients with outpatient surgical procedures in the oral cavity by potentiating the action of the drugs used and prolonging their action.

The task is achieved by the use of the following preventive complex: apply before and after surgery solution for local use Tantum Verde", which has antiseptic, anti-inflammatory and analgesic properties, and conduct in the area of the surgical intervention rate intraoral electrophoresis of a 10% solution of Dimexidum, further ensuring anti-inflammatory and immunotropic action.

It is known that surgical intervention in the oral cavity are at increased risk of inflammatory complications. Microbial contamination of the surgical wound during surgery is inevitable even with perfect compliance with the rules of asepsis. On the development of microbial infection in the postoperative period is influenced by the state of local and General immunity of the patient, the nature of preoperative preparation, but one of the main factors is the degree�tier microbial contamination. In systemic prophylactic use of antibiotics need only high-risk patients with somatic burdened anamnesis, and in the case of operations on an initially infected tissues. In other cases, it is possible to provide the antimicrobial debridement of the wound with local resources on the background of observance of rules of hygiene of the oral cavity. In addition, the inflammatory process in maxillo-facial area always accompanied by pain of varying severity, which negatively affects the health of the patient (Tsarev V. N., Ushakov R. V. antimicrobial therapy in dentistry: a Guide. - M: Medical information Agency. - 2004. - 144 p.; Sohow S. T. et al. Comparative evaluation of the postoperative period in the treatment of alveolitis, periostitis, pericoronitis and retention of the teeth in the application of non-steroidal anti-inflammatory drugs and traditional treatment. Materials XXVIII all-Russian scientific-practical conference "stomatology of the XXI century". M - 2012. - Pp. 182-183; Tsarev V. N., Ushakov R. V. Local antimicrobial therapy in dentistry: a Training manual. - M: Medical information Agency. - 2004. - 136 p.).

Therefore, the prevention of inflammatory complications in patients with outpatient surgical procedures in the oral cavity should be aimed at eliminating pathogens�th microflora, inflammation of the tissues and pain in the surgical wound, as well as the correction factors of local immunity.

Dimexide (dimethyl Sulfoxide) is a colorless transparent liquid with specific odor, miscible with water and alcohol. When applied topically has anti-inflammatory effect, the mechanism of which consists in the inhibition of free radicals in inflammation and improves the metabolism and creates favorable conditions for the restoration of normal structure and function of the tissues of the affected area. Dimexide can enhance local immunity by increasing the number of epithelial cells and their adhesive abilities, as well as the normalization of indicators of phagocytic activity of neutrophils in gingival and capillary blood. Dimexide has a moderate analgesic, antiseptic and fibrinolytic action, perfectly penetrates through the mucosa and the skin, improves their permeability to other drugs, increases the permeability of the cell membranes of bacteria and increases the effectiveness of concomitant antibiotic therapy (Mashkovsky M. D. Medicines. In two parts. 4.1. - 12th ed., - M.: Medicine, 1993. - p. 222-223; a patent for the invention "Method of treatment of hronicheskoj� apical periodontitis" No. 2300371 from 10.06.2007. Cherepanov A., Leonova L. E., Kolomeitsev V. F., etc.).

Physiotherapeutic methods occupy an important place in the complex of preventive measures, to speed up the relief of pain and inflammation, to stimulate the processes of regeneration, to reduce the risk of complications. Method drug electrophoresis allows you to create from several hours to several days of high local concentration of the drug in the surgical area, where there is hemodynamic instability. Earlier in the postoperative period procedure intraoral electrophoresis of a 10% solution Dimexidum on the area of surgical intervention was not applied (Efanov O. I., Janakova T. F. physical Therapy of dental diseases. M.: Medicine, 2002-165 S.).

The drug is "Tantum Verde" is produced by company A. C. R. Angelini Francesco (Italy). The active ingredient is benzydamine hydrochloride, a nonsteroidal anti-inflammatory drug belonging to the group of indazole, anti-inflammatory action, which is associated with the stabilization of cell membranes and inhibition of prostaglandin synthesis.

Benzydamine has a pronounced antibacterial and specific antimicrobial activity against a broad spectrum of microorganisms due to the rapid penetration through the membrane with subsequent disturbances�Agency of cellular structures a metabolic and lysosomes of cells, has antifungal activity against Candida Albicans. Causes structural modifications of the cell wall of fungi, thus preventing their reproduction.

Local anesthetic action "Tantum Verde" is based on the blockade of nerve impulses and stabilization of sensory receptors. The drug has epithelizing action, optimizing conditions for reparative regeneration of tissues. The local application of the drug is well absorbed through the mucous membranes and penetrates the tissues, does not have a systemic effect.

The method is as follows. Outpatient surgical procedures in the oral cavity the patient should be administered before surgery for 5-6 days of twice-daily oral rinse at a dose of 15 ml of 0.15% solution "Tantum Verde" and after the operation - in the form of baths for 2-3 minutes, 3-4 times a day course of 5-7 days.

Additionally, after the surgery procedure carried out daily intraoral electrophoresis 10% Dimexidum with the anode in the area of surgical intervention in the amount of 5-7 sessions.

Examples of specific performance.

Example 1.

Patient S., 33

1 visit

The complaints of intermittent, aching pain throughout the month associated with the difficult eruption of the lower right wisdom tooth�ti". The presence of somatic and infectious diseases denies, allergic history calm.

The results of the survey: exterior corresponds to the age of the patient, the face is symmetrical, skin pale pink color, the regional lymph nodes were not palpable. Mouth opens freely determined orthognatic bite. The mucous membrane of the lips, mouth, gums pink wet, shiny. In the area of the anterior teeth and lingual surfaces of lower molars, there is a moderate amount of plaque, swelling and bleeding of the interdental papillae during probing. Mucosa in the area of tooth 4.8 edematous, hyperemic. Medial tubercles of the crown 4.8 of tooth-free gums, tilted downward and adjacent to the distal surface of the crown 4.7 tooth, distal part of the crown is closed by the mucous membrane of the gums. Percussion and palpation 4.8 moderately painful tooth.

Index assessment of dental status: KPU=7 (0, 6, 1); OHI-S=1,9; PMA=20,2%; CPITN=1,2.

On the radiograph is determined by the anomalous position of 4.8. tooth, medial root is in the area of the mandibular canal, there is a source of destruction of bone tissue 2×3 mm, semicircular shape with clear boundaries in the area of the distal root.

The results of microbiological testing for total contamination of the oral cavity: Neisseria mucosa - 1×10 4CFU/ml; Streptococcus mitis 1×104CFU/ml; Streptococcus parasanguinis - 1×104CFU/ml.

Diagnosis: dystopia 4.8 tooth, pericoronitis in the field of 4.8 tooth, chronic catarrhal gingivitis mild.

Treatment: conducted professional oral hygiene, learning the rules of hygiene, bath with 0.15% solution "Tantum Verde" 15 ml per tooth 4.8.

Recommendations: hygiene of the oral cavity, the use of rinse 0.15% solution "Tantum Verde" 15 ml, 2 times a day for 5 days before the operation.

2 visits in 6 days

No complaints. The condition is satisfactory. The body temperature was 36.6°C.

Survey results: the mucosa of the mouth and gums are pink in color, moist, marginal gums dense, bleeding is absent. In the field of 4.8 tooth mucosa and gums pink, painless.

Diagnosis: dystopia 4.8 of the tooth.

Treatment: infiltration and toryalai anesthesia Sol. Ultracaini 4% - 2 ml are made "L"-shaped incision through the mucous membrane and the periosteum in the area of tooth 4.8, peeled Muco-periosteal flap. With the help of elevators and forceps 4.8 the tooth is removed, treatment of the cavity of 0.05% chlorhexidine solution and filling it with pellets of kalapana, flap sutured with catgut, topically - cold.

Recommendations: hygiene of the oral cavity, the use of trays for 2-3 �in with a 0.15% solution "Tantum Verde" 15 ml 4 times a day, electrophoresis of a 10% solution Dimexidum on the area of surgical intervention No. 7.

3 visit - 2 days after the operation

Complaints of periodic aching pain in the tooth 4.8. The condition is satisfactory. Body temperature 37,0°C.

The results of the survey: the face is symmetrical, skin pale pink color, the regional lymph nodes were not palpable. Opening the mouth is painful. Mucosa in the area of 4.8 tooth slightly edematous, hyperemic, painful on palpation. The seams are wealthy, detachable no.

Recommendations: hygiene of the oral cavity, the use of trays for 2-3 min with 0.15% solution "Tantum Verde" 15 ml 4 times a day for 5 days, the continuation of the course of electrophoresis of a 10% solution Dimexidum on the area of surgical intervention.

4 visit - 8 days after the operation

No complaints. The condition is satisfactory. The body temperature was 36.6°C.

The results of the survey: the face is symmetrical, skin pale pink color, the regional lymph nodes were not palpable, opening the mouth free. In the field of 4.8 tooth mucosa and gums pink, painless, the seams are saved.

Index score: OHI-S=0,33; PMA=1,9%; CPITN=0,2.

The results of microbiological testing for total contamination of the oral cavity: Neisseria mucosa is detected�hree; Streptococcus mitis - 1×102CFU/ml; Streptococcus parasanguinis is not found.

Treatment: drug treatment of the joints of 0.05% chlorhexidine solution, removal of the stitches.

Example 2. Patient P., age 31

1 visit

Complaints: painful swelling in the region of the upper Central incisors, which appeared about a year ago.

History: a year ago in the region of the upper Central incisors was mechanical injury.

The presence of somatic and infectious diseases denies, allergic history calm.

The results of the survey: exterior corresponds to the age of the patient, the face is symmetrical, skin pale pink color, the regional lymph nodes were not palpable. Determined orthognatic bite. The mucous membrane of the lips, mouth, gums pink. In the upper and lower front teeth have a small amount of plaque. Mucosa in the area 1.1 and 1.2 of the teeth hyperemic, revealed flattening and bulging of the arch of the vestibule of the mouth round shape with clear boundaries, with palpation symptom fluctuation. Teeth 1.1,1.2 movable mouth opens freely.

Index assessment of dental status: KPU=10 (0, 8, 2); OHI-S=2,5; PMA=29,0%

The results of microbiological testing for total contamination of the oral cavity When conducting microbiological research�of Avani on total contamination of the oral cavity, it was revealed Streptococcus mutans 1×104CFU/ml Streptococcus haemoliticus 1×104CFU/ml Enterococcus faecium 1×105CFU/ml.

On radiographs in the apex of the roots 1.1,1.2 of the teeth is determined by bone tissue destruction round shape with clear boundaries, with a diameter of 0.8 cm

Diagnosis: cyst, root-planing 1.1,1.2 teeth.

Treatment: conducted professional oral hygiene, learning the rules of hygiene, sealing of channels 1.1,1.2 teeth. Recommendations: hygiene of the oral cavity, the use of rinse 0.15% solution "Tantum Verde" 15 ml 2 times a day for 5 days before surgery

2 visits - 5 days

No complaints. The condition is satisfactory. The body temperature was 36.6°C.

Survey results: the mucosa of the mouth and gums are pink in color, moist, marginal gums dense, bleeding is absent.

Treatment: under infiltration anesthesia Sol. Ultracaini of 1.7. On the vestibular surface of the alveolar bone is made trapezoidal incision in region 11, 12, separated Muco-periosteal flap. Using a periosteal Elevator, the Elevator and surgical spoon has otsaila shell of the cyst. For selection of sheath cysts spherical boron sawed the tops 11, 12, to the level of the surrounding bone and pulled. Audited the bone cavity, smoothed the sharp bone edges. The cavity is filled with granules �of alapana. The flap is sutured to Miriam, iodoform strip. Local cold.

Recommendations: hygiene of the oral cavity, the use of trays for 2-3 min with 0.15% solution "Tantum Verde" 15 ml 4 times a day, electrophoresis of a 10% solution Dimexidum on the area of surgical intervention No. 7.

3 visit - 2 days after the operation

Complaints: notes periodic moderate pain in the area of surgical intervention.

Objectively: the condition is satisfactory, the face is symmetrical. Regional lymph nodes were not palpable. The hygienic condition of the oral cavity is good. Mucosa in the area of 1.1, 1.2 teeth slightly hyperemic, edematous. The seams are wealthy. During the re-microbiological studies on total contamination of the oral cavity revealed Streptococcus mutans 1×102CFU/ml.

Recommendations: hygiene of the oral cavity, the use of trays for 2-3 min with 0.15% solution "Tantum Verde" 15 ml 4 times a day for 5 days, the continuation of the course of electrophoresis of a 10% solution Dimexidum on the area of surgical intervention.

4 visit - 7 days after the operation

No complaints.

Objectively: the condition is satisfactory, the face is symmetrical. Regional lymph nodes were not palpable. The hygienic condition of the oral cavity is good. Mucosa in the area of 1.1,1.2 zu�s pale pink. The seams are wealthy.

Index assessment of dental status: OHI-S=0,6; PMA=6,0%

Treatment: drug treatment of the joints of 0.05% chlorhexidine solution, removal of the stitches.

Example 3.

Patient N., 35

1 visit

Complaints: the availability of education in the area of the lower lip on the right.

History: formation appeared two months ago, occasionally biting his lower lip. Concomitant or previous diseases: chronic gastritis, infectious diseases, allergic history calm.

The results of the survey: exterior corresponds to the age of the patient, the face is symmetrical, skin pale pink color, the regional lymph nodes were not palpable. Determined orthognatic bite. The mucous membrane of the lips, mouth, gums pink, wet, mouth opens freely. On the mucous membrane of the lower lip on the right has a hemispherical elevation, whitish color with clear boundaries, diameter 1 cm, palpation of elastic consistency, painless.

Index assessment of dental status: CPU=8 (0,8,0) OHI-S=1,3; PMA=11,0%

Diagnosis: retention cyst of the lower lip on the right.

Treatment: conducted professional oral hygiene, learning the rules of hygiene

Recommendations: hygiene of the oral cavity, the use of rinsing with 0.5% solution "Tantum Verde" 15 ml. 2 times a day for 5 days before the operation.

2 visit

No complaints. The condition is satisfactory. The body temperature was 36.6°C.

Survey results: the mucosa of the mouth and gums are pink in color, moist, marginal gums dense, bleeding is absent.

Diagnosis: retention cyst of the lower lip on the right.

Treatment: under infiltration anesthesia Sol. Novocaini 2% to 1.5 ml, made convergent semi-oval incision of the mucosa over the cyst. Blunt shell of the cyst is separated from the surrounding tissue, connective tissue dissected jumpers, cyst highlighted. Suturing with catgut. Local cold.

Recommendations: hygiene of the oral cavity, the use of trays for 2-3 min with 0.15% solution "Tantum Verde" 15 ml 4 times a day, electrophoresis of a 10% solution Dimexidum on the area of surgical intervention No. 5.

3 visit - 6 days after the operation

No complaints.

Objectively: the condition is satisfactory, the face is symmetrical. Regional lymph nodes were not palpable. The hygienic condition of the oral cavity is good. Mucosa in the area of surgical intervention pale pink, painless. The seams are wealthy.

Index assessment of dental status: OHI-S=0,4; PMA=0%

Treatment: drug treatment of the seams of a 0.05% solution of chlorhex�Dean, suture removal.

The method of prevention of inflammatory complications in patients with outpatient surgical procedures in the oral cavity by holding before surgery within 5-6 days of twice-daily oral rinse at a dose of 15 ml of 0.15% solution "Tantum Verde" and after the operation - in the form of baths for 2-3 minutes, 3-4 times a day course of 5-7 days, characterized in that it further after the operation carried out daily procedure intraoral electrophoresis of a 10% solution Dimexidum with the anode in the area of surgical intervention in the amount of 5-7 sessions.



 

Same patents:

FIELD: medicine.

SUBSTANCE: opening of a carious cavity, ablation of overhanging enamel edges on the entire circumference, necrectomy and drug treatment with a 0.06% chlorhexidine solution are performed. The preparation "Lemifaren" is applied on walls and bottom of the carious cavity in a uniform 1 mm thick layer, which is left for 1 day under temporary filling. After the removal of the preparation irradiation in a pulse mode with the power of 5 W and frequency of 2000-3000 Hz is carried out for 5 min with the application of the laser apparatus ALST-01. After that, the cavity is restored with an account of functional and aesthetic parameters of the particular tooth.

EFFECT: effective treatment of deep caries prevents caries recurrences and pulp inflammation.

1 ex

FIELD: medicine.

SUBSTANCE: group of inventions relates to medicine and is intended for oral cavity care. Compositions contain: a) guanidine-based active substance, b) film-forming polymer, c) hydrophobic modifier of viscosity in quantity, sufficient for provision of composition for oral cavity care with time particle sedimentation more than 20 minutes, and d) oil carrier. Guanidine-based active substance preferably represents L-arginine. Film-forming polymer preferably represented GANTREZ. Hydrophobic modifier of viscosity preferably represents thickened mineral oil. Oil carrier preferably represents natural oil. Composition is enclosed in gelatine capsule. Method of teeth cleaning includes application on teeth of composition for oral cavity care in such a way that composition for oral cavity care cleans teeth. Device for oral cavity care, which contains: handle, fastened on handle head, where head has external surface and a row of teeth-cleaning elements, projecting outwards on external surface, and gelatine capsule, which contains composition for oral cavity care, located on head.

EFFECT: group of inventions makes it possible to increase teeth cleaning efficiency.

14 cl, 2 ex, 1 tbl

FIELD: medicine.

SUBSTANCE: implementing the presented method involves mixing gel Hyaludent 1 ml on a slide with Betaleukin 0.0005 ml dissolved in water for injections 1 ml; the produced content is applied with a single application syringe on a desalivated treated area of the involved periodontal tissues and left until completely absorbed for 1-3 minutes; the involved area is exposed to laser light generated by the laser semiconductor dental therapeutic apparatus Optodan with a periodontal tip in the mode II, with the exposure length for 3-5 minutes; the therapeutic course is 8 days daily.

EFFECT: using the method enables achieving the fast regeneration length, ensuring the intact periodontal state in the most patients.

4 tbl, 3 ex

FIELD: medicine.

SUBSTANCE: invention represents an agent for treating a pulp inflammation differing by the fact that it contains Bezornil ointment and Dycal ivory paste in ratio 1:1 blended until smooth.

EFFECT: invention provides relieving oedema and pain on the day of doctor's appointment, accelerating the pulp tissue regeneration process, creating the reparative dentin within 30 days, and ensures the higher clinical effectiveness in the pulp inflammations.

2 ex, 1 tbl

FIELD: medicine.

SUBSTANCE: a phytopreparation containing bee wax 1.9 g and a herbal extract 0.1 g with the above herbal extract containing common oak bark, common St. John's wort herb and creeping thyme (Thymus) herb in equal proportions is used.The preparation is used as a chewing substrate (a chewing gum) for two weeks 3 times a day 15 minutes after meals.

EFFECT: using the invention improves clinical manifestations of the disease; oral inflammations are supposed to relieve or reduce; the length of erosion and ulcer epithelisation is reduced; the oral fluid structural properties are normalised by increasing phosphorus and magnesium, reducing protein, calcium and TBA.

1 tbl, 1 ex

FIELD: medicine.

SUBSTANCE: vitamins A and E, novocaine blocades of parotid salivary glands, intake of potassium iodide solution, intake of galantamine, additionally administered is "Vezugen" in a dose of 2 tablets (capsules) 2 times per day for 30 days are administered.

EFFECT: invention makes it possible to stimulate the formation of own saliva in patients in case of drug sialoadenopathy, conditioned by chemotherapy of malignant tumours.

2 ex

FIELD: medicine.

SUBSTANCE: 20-25 minutes after surgical intervention, a mouth bath of an implantation area with the Tonsinal phytopreparation diluted in an amount of 2.5 g in 100 ml of boiled water of room temperature is executed. 20-25 minutes later the Plastin CM-1 phytopreparation is applied on the alveolar process mucosa within the implantation area from the vestibular side for 1.5-2 hours. That is preceded by the desalivation of the oral cavity and mouth rinsing carefully with the Tonsinal solution trying to avoid any dynamic movements. The above procedures are performed 3-4 times a day for at least 10 days.

EFFECT: more effective dental implantation by improving microcirculation, fast normalising of oral microbiocoenosis, wound surface healing by immediate union, reliable implant attachment to gums and providing the implant stability.

3 ex

FIELD: medicine.

SUBSTANCE: group of inventions relates to medicine, namely to dentistry, and can be used for the treatment of conditions, related with the increased expression of MMP-13, selected from the group, consisting of loss of one or more teeth fixation, teeth loss, teeth mobility, formation of recesses, bone tissue loss and a combination of two and more of the said conditions. For this purpose the application of 4-acetamidophenyl 2-isopropyl-5-methylcyclohexylcarbonate in the production of a medication for the treatment of the said conditions is claimed. A composition for teeth care, containing an orally acceptable carrier and a therapeutically effective quantity of a MMP-13 inhibitor in the form of 4-acetamidophenyl 2-isopropyl-5-methylcyclohexylcarbonate is also claimed.

EFFECT: group of inventions provides the effective treatment of the said conditions die to effective MMP-13 suppression.

3 cl, 5 tbl, 5 ex

FIELD: medicine.

SUBSTANCE: method involves professional oral hygiene is carried out consisting in ultrasonic removal of supra- and subgingival dental deposits and polishing of supragingival teeth. Bite splinting and recovery of dentition integrity may be required. After dissecting a mucoperiosteal flap according to the known technique, an incision area is sanitated by means of a photodynamic therapy (PDT). The PDT is conducted with the use of a diode laser at wave length 660±5 nm and emitting power 0.5-1.0 Wt. The photosensitiser "Photoditasin" in the form of 0.5% gel is introduced by means of a cannula into dental gaps, under the dissected segments of the flap and onto the mucosal tissue for 5 minutes. The photosensitiser is washed out, and the gingival pockets are repeatedly exposed to laser light for 2-3 min in the same environment. Sterile osteoplastic material is introduced into bone defects, and the flap is sutured together.

EFFECT: effective cleansing of the surgical area, eliminating the periodontal inflammation, stimulating tissue osteogenesis and regeneration, stabilising the processes of bone tissue absorption of alveolar interdental septa and preserving the tissues.

2 cl, 1 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to the pharmaceutical industry, namely to an oral care composition and to a method for increasing the solubility of an active ingredient recovered from magnolia extract - tetrahydrohonokiol. The oral care composition contains an active ingredient recovered from the magnolia extract - tetrahydrohonokiol, propylene glycol and an orally acceptable carrier, in a certain amount.

EFFECT: content of the certain amount of propylene glycol in the oral care composition increases the solubility of tetrahydrohonokiol that leads to improving the effectiveness of its delivery and bioavailability.

3 cl, 8 tbl, 8 ex

FIELD: medicine.

SUBSTANCE: phenazepamum 1.0 mg is prescribed per os to patient on the eve of planned operation; then, in pre-narcosis room after catheterisation of peripheral vein suprastinum in dose 0.3 mg/kg of patient's body weight and atropine in dose 0.01 mg/kg of patient's body weight are introduced intramuscularly 30 minutes before operation. After that, solution of dexmedetomidine with concentration 4.0 mkg/ml in dose 1.0 mcg/kg of patient's body weight is introduced by intravenous infusion by syringe-batcher for 10 min.

EFFECT: method ensures optimal level of sedation and stability of haemodynamics indexes at the background of reduction of patient's psycho emotional stress and preservation of their contact with medical staff.

2 ex

FIELD: medicine.

SUBSTANCE: what is described is a microdispersed histo-equivalent bioplastic material containing hyaluronic acid, a buffer system, clarithromycin and a proton pump inhibitor. Hyaluronic acid is nanostructured, lyophilised and dispersed to powder with a single particle size falling within the range of 50-100 mcm; the buffer system is Buffer-G with pH 6.8-8.0, while the proton pump inhibitor is the inhibitor H+-K+-Adenosine triphosphatase pantoprazole in the following proportions, wt %: hyaluronic acid - 95, Buffer-G with pH 6.8-8.0- 3, pantoprazole -1, clarithromycin -1; the microdispersed histo-equivalent bioplastic material is placed into capsules melted on exposure to body temperature, e.g. gelatine.

EFFECT: using it for the therapeutic treatment of gastroduodenal ulcers and erosions with the effect of accelerated oral tissue regeneration.

1 tbl

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to pharmaceutical composition, containing compound of formula or for prevention or treatment of diseases, associated with oxidative stress, selected from group, consisting of MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis and stroke episodes), MERRF syndrome (myoclonic epilepsy with ragged red fibres) or Kearns-Sayre syndrome, arrhythmia, cardioplegia or myocardium infarction. in formula (1) na stands for 1 or 2, Aa represents 5-membered heteroaryl or heterocycle, each of which has 2 heteroatoms, selected from N, O and S, Rla represents R5a-Xa-Ba-X′a-, Ba represents direct bond, Xa and X′a independently on each other represent direct bond or -OC(O)-, R5a represents hydrogen or 6-9-membered monocyclic or condensed cyclic heterocycle or heteroaryl, each of which has from 1 to 3 heteroatoms, selected from N, O and S, and is optionally substituted with oxo or C1-C6-alkyl, R2a represents -(CR8aR9a)pa-Ya-R7a, pa stands for number from 0 or 1, Ya represents direct bond or -O-, R7a represents hydrogen or phenyl, R3a, R8a, R9a, R10a represent hydrogen, R4a represents -(CH2)pa-Da-R10a-, Da represents C5-cycloalkyl or 6-membered heterocycle, which has 1 heteroatom, selected from N, S and O. Radical values for formula (2) are give in invention formula.

EFFECT: obtaining compositions for prevention or treatment of diseases, associated with oxidative stress.

19 dwg, 5 tbl, 3 ex

FIELD: medicine.

SUBSTANCE: anaesthetising patients with chronic pain syndrome undergoing a cyclophotocoagulation surgery involves the intravenous administration of the hormonal preparation dexamethasone in a dose of no more than 8 mg followed by the anxiolytic droperidol in a dose of no more than 2.5 mg 5 minutes prior to the operation before the peribulbar anaesthesia. A peripheral block in the form of the peribulbar anaesthesia involving administration of no more than 6 ml of a local anaesthetic follows. At the moment the surgical procedure starts, benzodiazepin, e.g. diazepam, is administered in a dose of no more than 5 mg.

EFFECT: achieving adequate anaesthesia in the given category of patients by blocking all the links of a pathological pain chain.

1 ex

FIELD: chemistry.

SUBSTANCE: invention relates to field of organic chemistry, namely to novel compound - 5(6)-nitro-1-(thietanyl-3)-2-ethoxybenzimidazole, inhibiting peroxidation of lipids.

EFFECT: novel compound, possessing useful biological properties, has been obtained.

2 cl, 1 dwg, 2 ex

FIELD: nanotechnology.

SUBSTANCE: albendazole is added in small portions to the suspension of sodium alginate in hexane in the presence of the preparation E472c while stirring, carbon tetrachloride is poured, the resulting suspension is filtered and dried at room temperature.

EFFECT: simplifying the process of production of the said capsules, the reduction of losses, and increase in the yield by weight.

2 ex

FIELD: medicine.

SUBSTANCE: invention represents method of medication encapsulation by method of precipitation with non-solvent, characterized by the fact that as core of nanocapsules albendazole is applied, as casing - sodium alginate, which is precipitated from suspension in butanol by addition of chloroform as non-solvent at 25°C.

EFFECT: simplification and acceleration of nanocapsules obtaining process, reduction of loss in obtaining nanocapsules.

2 ex

FIELD: chemistry.

SUBSTANCE: invention provides a method of encapsulating a medicinal preparation via non-solvent addition, characterised by that the core of the microcapsules used is fenbendazole, the envelope used is sodium carboxymethyl cellulose which is deposited from a solution in toluene by adding, as the nonsolvent, carbinol and water at 25°C.

EFFECT: simpler and faster process of producing microcapsules and reduced losses when producing microcapsules.

3 ex

FIELD: chemistry.

SUBSTANCE: invention provides a method of encapsulating a medicinal preparation via non-solvent addition, characterised by that the core of the microcapsules used is fenbendazole, the envelope used is sodium carboxymethyl cellulose which is deposited from a solution in cyclohexanol by adding, as the nonsolvent, isopropanol and water at 25°C.

EFFECT: simpler and faster process of producing microcapsules and reduced losses when producing microcapsules.

3 ex

FIELD: chemistry.

SUBSTANCE: invention provides a method of encapsulating a medicinal preparation via a nonsolvent deposition method, characterised by that the core of the nanocapsule used is fenbendazole, the envelope used is pectin, which is deposited from a suspension in benzene by adding tetrachloromethane as the nonsolvent at 25°C.

EFFECT: simpler and faster process of producing microcapsules, reduced losses when producing microcapsules.

6 ex

Antimicrobial agent // 2556509

FIELD: medicine.

SUBSTANCE: compound 2-(1'-hydroxy-4'-isopropenyl-1'-methylcyclohexyl-2'-thio)-methylethanoate having structural formula I: is applicable as an antimicrobial agent.

EFFECT: using the compound of formula I possessing antimicrobial activity provides treating infectious processes caused by susceptible organisms.

5 tbl

Up!