Device with higher echogenicity
SUBSTANCE: invention relates to medical equipment, namely to means with higher echogenicity for obtaining ultrasonic images. Intervention device contains intervention device, for which obtained is ultrasonic image, which has external surface, containing one or more topographic irregularities of in other cases smooth surface of intervention device and polymer film, which is in tight contact with external surface and closed at least part of one or more topographic irregularities, with tension of polymer film and resonance characteristic of polymer film are adjustable. In method of increasing echogenicity one or more topographic irregularities of in other cases smooth external surface of intervention film is (are) formed, with polymer film being placed in tight contact with external surface, with tension of polymer film being adjustable. Echogenic response of intervention device is regulated by means of device visualisation of device and regulation of polymer film tension, with adjustment of tension changing resonance characteristics of polymer film, covering one or more topographic irregularities.
EFFECT: application of invention makes it possible to improve visibility of objects in ultrasound.
13 cl, 4 dwg
The technical field to which the invention relates
The invention relates to a device with increased echogenicity for better visualization while obtaining ultrasound images and to methods for increasing the echogenicity of the device.
The prior art inventions
Ultrasonic technology has advantages over other methods of obtaining images. Along with the advantage for health due to the reduction or exclusion of irradiation by x-rays (fluoroscopy), the necessary equipment is quite compact, which is convenient to move, and has the advantage in the diagnosis of the morphology of sub-surface tissues. Additionally, the ultrasonic transducers can be manufactured small enough to be placed inside the body, where they can provide better resolution than the converters currently available for magnetic resonance imaging and x-ray computed tomography. Additionally, improvements to devices that increase their echogenicity for the use of ultrasound allows clinicians to quickly and properly to care for patients, saving time and money.
Numerous interventional tools and instruments are designed with polished surfaces, �matured make the tools in essence, invisible to ultrasound. Interventional tools and instruments are referred to here as “device (s)'. The present invention relates to improvements in devices that can improve the echogenicity of interventional devices. To interventional devices include, in particular, septal puncture needle, as well as implantable devices, such as, in particular, stents, filters, stent graphs and/or heart valves.
The improvement of devices for ultrasound imaging or “echogenicity” have been studied for many years. When sound waves come into contact with the smooth surface, the angle of incidence and angle of reflection are equal. If the object is at an acute angle, most or all of the sound waves reflected from the power transmission/receiver. At such acute angles even devices with high reflectivity can be invisible to ultrasound, if the dispersion does not send the sound back to the source transducer. Conversely, if the object is perpendicular to that of sound waves reflected straight back, can cause the effect of “blinding” and impede the inspection of the object by the operator. This undesirable effect is referred to as specular reflection.
Manufacturers of medical devices have tried many ways of improving� the visibility of objects in ultrasound. Examples include roughening the surface of the device, the capture of gas, the adhesion of particles to surfaces of the substrates, creating indentations or holes in the substrate and the use of dissimilar materials.
Summary of the invention
One object of the present invention relates to an interventional tool or device with increased echogenicity. The interventional tool or device for which must be obtained ultrasonic image, has a surface with one or more holes and a polymer film are in close contact with the surface of the tool or device that covers at least the area of one or more holes.
Another object of the present invention relates to a method for increasing the echogenicity interventional tool or device. In this method, one or more holes are in the surface of the interventional tool or device. The polymer film is then placed in close contact with the surface, covering at least the area of one or more holes.
Brief description of the drawings
Fig.1 - interventional tool or device with a plurality of holes in its surface.
Fig.2A and 2B is the same interventional tool or device shown in Fig.1, with a polymer film on�adaweya in close contact with the surface of the device so openings are closed.
Fig.3 - bar chart showing expressed in dB results increase compared with the control sample for the device corresponding to the present invention, with a polymer film that covers the hole in the surface of the device, as shown in Fig.2A and 2B, and other commercially available device with a coating.
Fig.4 is a graph of the reflected energy at various angles, which reflects the improved echogenic response.
Detailed description of the invention
The present invention relates to an improvement that can improve the echogenicity of these interventional devices. Device with increased echogenicity corresponding to the present invention comprises a device, the image of which must be obtained by means of ultrasound, having a surface with one or more holes. Interventional device corresponding to the present invention, further comprises a polymer film, which is in close contact with the surface of the device covering at one or more of the holes.
Examples of interventional tool or device that may be improved visibility in obtaining ultrasonic images in accordance with the present invention are, in particular, to such medical�e device, as a permanently implanted or temporarily installed devices, such as catheters, wire guides, stands and other accessories and tools, intervention tools and needles, such as septal puncture needle. However, as should be understood specialists in the art after reading the present disclosure, the methods described here improve the visibility of the device upon receipt of ultrasound images can be adapted for many other areas and devices.
In accordance with the present invention, one or more holes are in the surface of the interventional tool or device. Holes corresponding to the present invention, there may be slits in the surface, which in other cases is a smooth surface of the device, or through holes through the surface of the device, or grooves formed in the surface of the device, or any other topographic irregularities in that in other cases the smooth surface of the device.
In one of the embodiments, as shown in Fig. 1, in the surface of the interventional tool or device for making the plurality of holes.
In one of variants of implementation, in addition to the holes in the surface of the interventional device�VA surface is also rough. In one of the embodiments of the surface roughness of the device has an average value of surface roughness less than 1 micron.
In embodiments in which the polymeric film is engaged with the device, making the surface roughness can be useful to increase adhesion.
The echogenicity of the present device is increased in accordance with the present invention by placing echogenic polymer film in close contact with the surface of the device to close the at least plot holes or openings in the surface of the interventional tool or device. In one of the embodiments of the polymer film covers the entire hole or holes in the surface of the interventional tool or device. In one of the embodiments of the polymer film covers the entire surface of the interventional tool or device. The coated polymer film can also restore luminal ability to pass medical devices (needles, dermatome, etc.), which must be added through holes. In the case of the slits or grooves, polymer film, especially a film of ePTFE, can restore the smoothness of the surface, which may be useful in most endoluminal procedures.
In some variations�tah implementation of the present invention, the echogenic characteristics of the device can be adjusted. One embodiment of the adjustable device comprises a hollow with through holes in the surface, a closed thin polymer film. The pressure inside the device can increase or decrease to change the resonance characteristic of the polymer film covering the said openings to create change echogenic characteristics of the device when viewed using ultrasound. In another embodiment, the implementation may be regulated by the tension of the polymeric film covering the opening of the device. Increasing or decreasing the tension of this polymer film, you can adjust the echogenicity of the device. The shape of holes may vary in order to achieve changes in echogenicity.
May be any biocompatible polymer film, suitable for echogenic response with minimal impact profile. In one of the embodiments of the polymer film contains a microporous fluoropolymer, such as penopolietilen (PTFE). In another embodiment of the polymeric film may be a thin polyolefin film, which may or may not be porous. Different thickness of material may change the topography, when the sleeve “activated”. Different topography will alter the echogenicity of the object. The thickness of the mentioned polymer films have bituminise 0.010 in. In another embodiment, the implementation of the thickness of the polymer film is less than 0.006 inches. In another embodiment, the implementation of the thickness of the polymer film is less than 0.003 inch.
Increased echogenicity of the device corresponding to the embodiment of the present invention, was demonstrated experimentally. The results are presented in Fig.3, which is measured in dB increase in echogenicity as compared with the control instance for the device corresponding to the embodiment of the present invention, and a device coated with Angiotech.
The following examples are not restrictive, are provided for further explanation of the present invention.
Example 1. Materials
The needle is stainless steel with a diameter of 0,040 inches and a length of 4.8 inches was used as the test object to the increase of echogenicity. Needle without modification was used as a control sample to compare the results of the modification. The echogenicity of the needle is made of stainless steel with many holes in it, covered with a polymer film in accordance with the present invention, also were compared with needle coated Angiotech (Angiotech Pharmaceuticals, Inc., 1618 Station Street, Vancouver, BC Canada V6A 1B6). The holes are staggered at an angle of 45° with the diameter 0,178 mm and a gap between them of 0.38 mm.
Example 2. Methods
DL� evaluate and compare the processed samples were used three different ways.
All samples were exposed to the system for obtaining images using the acoustic wave. Apparatus for testing consisted of a receiving/transmitting transducer with a frequency of 7.5 MHz, mounted on a base with a sample holder located at a distance of approximately 2.5 cm focal length Converter. The transducer frequency of 7.5 MHz was created oscillations with a wavelength (λ) of 200 microns. At a distance of 2.5 cm beam width was approximately 1 mm. the Sample needle was mounted in the holder, located perpendicular to the axis of the radiating transducer. This corresponds to the angle of 0 degrees. The sample holder is removable for easy change of the sample. Holder with a magnet is held in a rotating goniometer to measure the angle of the sample relative to the transmitting and receiving transducer. The sample and the transducer were immersed in a tank of water at room temperature. Before data collection, each sample was aligned with the transmitter. This was done by increasing the attenuation setting on the controller pulse exciter/receiver (approximately 40 dB) to prevent saturation of the received signal. The operator then visually controlled signal, while manually rotating the goniometer and switching knob fine adjustment �and the Converter, to achieve maximum return signal. The attenuation is regulated to the reference point, approximately 1 V. Setting the attenuation and the testimony of the goniometer was recorded. The goniometer was rotated by 10 degrees with respect to the recorded testimony. Since the deviation from the perpendicular direction the signal is usually reduced (mirror reading), the attenuation is decreased. A decreased level allowed us to have a powerful enough signal during data collection, without bringing the receiver to saturation. The sample was rotated around the rotation angle to ensure that the signal was not saturated, or substantially played at or near the inverter, outputting the signal from the window of data collection. Significant temporal shift was an indicator that the transmitter is not aligned with the center or point of rotation of the sample. When the setup was finished, the goniometer was moved to around 10 degrees and the collection of data points was performed to 50 degrees in increments of 2 degrees. To the inverter connected equipment, and test device measured the reflection. For data collection and subsequent analysis was performed with the software Lab View hardware and software.
The second evaluation of samples was performed with a silicone shell that is immersed in the blood of ATS laboratories to increase sathanae to create a more real environment image. Using ultrasound system with a transducer frequency of 6.5 MHz, the samples were inserted into an empty shell. For each sample received still image. These images were compared visually with the reference images and was tested for compatibility with two-dimensional data Converter. Data were collected at three different time points. Between collecting data in the second and third time Converter reset. Thus, although the absolute scale of the graphs in dB is not the same, the focus is on the relative difference (Delta).
The third assessment was the analysis of the surface using a Veeco optical comparator Model NT3300. All obtained data were further processed by computer software to better assess the samples. Macroscopic tilt and cylindrical curvature were removed. To filter the frequencies below the 20-1mm was chosen as the Gaussian filter (Fourier). Incomplete intermediate points were restored with a maximum resolution of 3 or 5 pixels. All samples were masked at the edges to remove the areas with large precipitation data and anomalies associated with filtering. Two-dimensional samples were processed first, followed by a three-dimensional samples.
To demonstrate the characteristics of a surface was used on�traveler roughness height, Rt or PV, which is the maximum height from the maximum peak-to-trough on the surface profile within the length of the evaluation.
Measured in dB increased echogenicity compared with the reference sample device, the corresponding variant of implementation, and a device coated with Angiotech, shown in Fig.3.
1. Interventional device with increased echogenicity containing:
(a) interventional device for which must be obtained ultrasonic image, wherein the said device has an outer surface containing one or more topographical irregularities in other cases, the smooth outer surface of the interventional device; and
(b) a polymer film which is in close contact with the outer surface of the specified interventional device and covers at least the area specified by one or more topographic irregularities,
thus the tension of the polymeric film and the resonant characteristics of the polymer film are adjustable.
2. Interventional device with increased echogenicity according to claim 1, wherein the specified one or more topographic irregularities are completely closed polymer film.
3. Interventional device with increased echogenicity according to claim 1, wherein the surface of the said device contains a variety of hole�rd.
4. Interventional device with increased echogenicity according to claim 1, wherein the polymer film covers the surface of the said device.
5. Interventional device with increased echogenicity according to claim 1, wherein the tension of the polymeric film covering the surface of the said device is adjustable.
6. Interventional device with increased echogenicity according to claim 1, wherein the polymer film contains a microporous fluoropolymer.
7. Interventional device with increased echogenicity according to claim 1, wherein the polymer film contains penopolietilen (PTFE).
8. Interventional device with increased echogenicity according to claim 1, wherein the interventional device is an interventional instrument.
9. Interventional device with increased echogenicity according to claim 1, wherein the interventional device is a septal puncture needle.
10. Interventional device with increased echogenicity according to claim 1, wherein the surface of the interventional device is made rough.
11. Interventional device with increased echogenicity according to claim 9, in which the surface has a roughness less than 1 micron.
12. A method for increasing the echogenicity of interventional device, comprising stages on which:
form one or more topographical irregularities in other�their cases smooth outer surface of the interventional device; and
place the plastic sheeting in close contact with the outer surface, so that covered at least the area specified by one or more topographic irregularities, and the tension of the polymeric film is adjustable, and
regulate the echogenic response of the interventional device, wherein said adjustment includes the stages at which
visualize the device via ultrasound, and
adjust the tension of the polymer film in response to the visualization, this adjustment of tension of the polymer film changes the resonance characteristic of the polymer film covering the specified one or more topographical irregularities.
13. A method according to claim 12, V. polymer film which is placed so as to completely close the specified one or more topographic irregularities of the interventional device.
SUBSTANCE: tissue regeneration or healing is stimulated when using a structure comprising a multilayer plate of a collagen membrane material, which contains a lamellated barrier material of pure collagen prepared of a natural collagen tissue; the lamellated barrier material containing a barrier layer with an outer smooth barrier surface and a fibre surface, which is opposite the outer smooth barrier surface. The structure additionally contains a matrix layer of a collagen sponge material adjoining the fibre surface.
EFFECT: matrix layer of the collagen sponge material is absorbed by an individual's body at a higher rate, than the lamellated barrier material.
20 cl, 3 dwg, 5 ex
SUBSTANCE: invention relates to the application of a solid medicinal product, which is heated under the impact of an alternating magnetic field, for further therapeutic treatment after surgical ablation of tumours and cancerous ulcers. The medicinal product represents a surgical implant, presented in the form of a physiologically acceptable fabric, sponge or film. The medicinal product contains magnetic particles, which generate heat when excited by an impact of the alternating magnetic field, and in this way, heat the medicinal product.
EFFECT: invention ensures considerable improvement of further treatment after operation on cancerous tumour in comparison with chemotherapy.
21 cl, 14 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to pharmaceutical industry, namely a method for preparing a filling material for plastic surgery and instrumental cosmetology. A method for preparing the filling material for plastic surgery and instrumental cosmetology consisting in the fact that sodium hyaluronate is prepared of cock's combs; a fraction of molecular weight 1000-2000 kDa is recovered; then sodium cations are substituted by cetylpyridinium cations; prepared hyaluronate ammonium salt is dissolved in an aprotonic solvent to produce internal esters; modified sodium hyaluronate is recovered by adding aqueous sodium chloride; sodium hyaluronate is deposited in acetone, dried and sterilised; thereafter the modified material is processed in a physiologically compatible aqueous solution to complete swelling and mechanically ground. The filling material for plastic surgery and instrumental cosmetology. The method for introducing the filling material for plastic surgery and instrumental cosmetology into problem area.
EFFECT: method enables preparing the biocompatible filling material with the pre-set physical-chemical properties.
3 cl, 3 tbl, 12 ex
SUBSTANCE: group of inventions refers to surgery and may be used for making external osteosynthesis implants. An osteosynthesis system comprises a piece part on an external surface of which there is a layer of a polymer film in the electret state with the layer of the polymer film made of a fusible element. The group of inventions refers to a method for making the osteosynthesis system involving preparation the layer of the polymer film on an external surface of the piece part by coating the surface of the piece system with a fine fusible polymer powder, fusion thereof on the surface of the piece part and electrostatic charging of the prepared film.
EFFECT: group of invention provides making a uniform coating of the electret layer on the surface of the piece part of the osteosynthesis system firmly attached to the surface of the piece part that enables faster fusion of bone fragments due to electric stimulation and prevented implant corrosion.
10 cl, 1 ex
SUBSTANCE: invention relates to N-substituted monomers and polymers, methods of producing such monomers and polymers and methods for their use for different medical purposes, e.g., in medical devices. Disclosed is a polymer which contains a repeating unit of formula (I), where X1 and X2 are independently selected from Br and I; y1 and y2 are equal to zero or an integer from 1 to 4, A1 is selected from a group consisting of , , , and , R3 is selected from C1-C30 alkyl, and C1-C30 heteroalkyl, C5-C30 aryl, C6-C30 alkylaryl and C2-C30 heteroaryl; R4 is selected from H, C1-C30 alkyl and C1-C30 heteroalkyl; R1 is (A) or (B); Z is O or S; R5 and R6 are selected from -CH=CH-, -CHJ1-CHJ2- and -(CH2)a-; a equals zero or an integer from 1 to 8; J1 and J2 are independently selected from H, Br and I; Q is a group which contains 20 or more carbon atoms; Rx is selected from optionally substituted branched or straight C7-C30 alkyl and optionally substituted C6-C30 aryl; and Ry is selected from hydrogen, optionally substituted branched or straight C1-C30 alkyl and optionally substituted C6-C30 aryl. Also disclosed are versions of said polymer, methods of producing said polymers and a medical device containing the disclosed polymers. The medical device is preferably a stent.
EFFECT: disclosed polymer has improved physical and chemical properties and is suitable for use in implantable medical devices.
31 cl, 1 dwg, 2 tbl, 3 ex
SUBSTANCE: group of inventions refers to medicine. What is described is a multilayer tissue adhesive sheet which contains a structure layer or a laminated plastic attached to a layer supposed to contact with tissue. The structure layer or the laminated plastic contains one or more synthetic polymers showing film-forming properties, while the tissue contact layer contains tercopolymer poly(VP-AAc-AAc(NHS)). The synthetic polymers showing film-forming properties are preferentially biodegradable polyesters, while the tissue reactive groups are most preferentially NHS-polyester groups.
EFFECT: sheet shows better flexibility and herewith keeps high adhesive strength.
26 cl, 2 dwg, 8 ex
SUBSTANCE: compositions, methods and sets applied to sealing of injured tissues are described herein; the compositions are produced by combining of the first transversally cross-linked component with the second transversally cross-linked component to the effect of formation of the porous matrix with spans, and combining of the porous matrix with the hydrocarbon gel forming component applied to filling-in at least some of the spans.
EFFECT: compositions have minimal turgescing properties.
15 cl, 15 tbl, 14 dwg, 26 ex
SUBSTANCE: invention refers to implants, in particular, to intracavernous or intravascular implants, and is preferable for treatment or preventive maintenance of coronary or peripheric narrowings or occlusions of vessels, in particular, narrowings, or stenosis or restenosis respectively, preferably for prevention of restenosis which, in chemically covalent or incovalent to the bound or physically fixed form, contain FK506, to the method of their obtaining and application.
EFFECT: reduction of inflammation centres.
52 cl, 7 dwg, 10 tbl, 9 ex
FIELD: medicine, plastic and reconstructive surgery.
SUBSTANCE: the present innovation deals with the ways for obtaining spongiform material out of biological tissues applied for treating contour skin deformations in plastic surgery or filling in volumetric defects of organs and soft tissues in reconstructive surgery. It is important to obtain spongiform material of wide functional properties and clinical efficiency. The method deals with mechanical purification of allogeneic connective-tissue neoplasms against the residues of adjacent tissues and foreign contaminations followed by washing in running water, treatment with 3%-hydrogen peroxide solution, rinsing in 0.9%-sodium chloride solution, homogenization till obtaining the homogeneous viscous mass to form the body of the required geometrical shape and size to subject it for frosting-defrosting cycles at the quantity of 2-7, moreover, frosting should be fulfilled steadily at the rate of about 0.1-1°C/min up to -40...-45°C to be kept at the temperature mentioned for 24 h followed by complete defrosting of biomaterial at +4°C, and in the course of the last cycle after frosting up to the desired temperature it is necessary to subject biomaterial for vacuum freeze drying to achieve the constant weight, then it should be hermetically sealed and sterilized with gamma-irradiation at the dosage of 2.5 MRad.
EFFECT: higher efficiency.
FIELD: medicine, thoracic surgery.
SUBSTANCE: the present innovation deals with treating the main bronchus stump during pneumonectomy and repeated operations on postoperational bronchial fistulas. One should apply an elastic hollow conductor under the bronchus, moreover, it is necessary to introduce one branch of pre-cooled clamp for soft tissues made of the fusion with a shape-memory effect. Then this conductor should be withdrawn out of operation wound, moreover, another branch should be applied onto opposite side of the bronchus. Then one should cover bronchial stump, tracheal bifurcation and adjacent tissues with granules out of porous titanium nickelide at particles size being ,1-1,0 mm at the quantity of 0.03-0.06 g/sq. cm. The innovation enables to decrease the number of postoperational complications, shorten the terms for healing bronchial stump and duration of operation due to proper applying the clamp for soft tissues.
EFFECT: higher reliability of sealing bronchial stump.
8 dwg, 3 ex
SUBSTANCE: invention refers to a contrast medium for ultrasonic imaging in the form of a preparative form. The declared medium contains microparticles a solid coating of which is presented in the form of a stabilizing formulation containing fine lecithin and polyethylene glycol of molecular weight 6000, filled with sulphur hexafluoride in the specific proportions. The preparative form may be suspended in a physiologically acceptable liquid suspension medium in a dose of 0.025-2.0 mg of the microparticles per 100 g of animal's body weight.
EFFECT: invention provides the improved ultrasonic images for at least 5 minutes, higher echogenicity of the analysed tissue.
5 cl, 2 ex
SUBSTANCE: invention relates to ophthalmology and is intended for volumetric echography of orbit in case of anophthalmia or subatrophy of eye. For this purpose claimed is immersion medium which represents cross-linked polymer hydrogel based on modified polyvinyl alcohol of general formula: where R - H, R1 - OH, R2 - unsaturated group, R3 - O-CO-R4, R4 - CH3 or residue of other acid, from polyvinyl ester of which polyvinyl alcohol was obtained, and m=80-99 mol %, n=0.5-15 mol %, k=0-12 mol %. Said emersion medium is used in echography method in form of 4-6 mm thick disc with size corresponding to opening into orbit. Disc is laid on anterior surface of closed eyelids.
EFFECT: invention ensures optimisation of orbit content image with absence of complications, trauma of eye tissues, as well as reduction of examination time and absence of psychological trauma.
2 cl, 5 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to medicine and describes a nanogel for ultrasound diagnosis containing a conductive gel of lightly crosslinked polymer of acrylic acid - Carbopol and a modifier - a solution of fullerene mixture in clove oil with its components found in the following proportions, wt %: Carbopol 0.9-1.1; fullerene mixture 0.0025-0.01 and clove oil 0.5-1.4 in the form of a solution of fullerene mixture in clove oil; glycerol 0-6; solution hydroxide to pH 6-8; water - added to 100. What is also described a method for producing nanogel.
EFFECT: ensured improvement of physical-chemical characteristics and antibacterial and photoabsorption activity in comparison with modified conductive gels.
4 cl, 5 ex, 4 tbl
FIELD: medicine, pharmaceutics.
SUBSTANCE: claimed invention relates to conjugates of phospholipids and direction peptide vectors, which bind with KDR with high affinity, as well as to methods of obtaining them.
EFFECT: such peptide-phospholipid conjugates can be components of compositions of echo-contrasting agents for US and are especially valuable in therapeutic and diagnostic methods, for example for visualisation of KDR-containing tissues and for estimation and treatment of angiogenic process in case of neoplasms.
33 cl, 11 dwg, 9 tbl, 17 ex
SUBSTANCE: to choose an endovascular therapeutic approach in the patients with hypertrophic obstructive cardiomyopathy, selective introduction of microbubbles-air-saturated physiologic saline (0.9% NaCl) in the septal branch of the anterior descending artery. The presented visualisation technique allows introducing ethanol in the septal arteries supplying the portion of the intraventricular septum that causes obstruction in the left ventricular outlet.
EFFECT: improvement of immediate and late results of the alcohol septal ablation.
1 ex, 6 dwg
SUBSTANCE: invention relates to medicine and medical therapy, to sphere of ultrasound therapy. Fluocarbon emulsion activator for highly-intensive focused ultrasound therapy (HIFU therapy) is described, which can increase sound therapy deposition at the target during HIFU therapy. The activator contains an internal phase consisting of nuclear substance encapsulated in membrane forming substance and continuous phase consisting of water medium. Internal phase is uniformly dispersed in continuous phase, particle size in the internal phase being within 0.1-1 mcm; the amount of membrane forming substance in the activator being 0.1-100 g/k; nuclear substance consists of liquid with liquid-gas transition within the range of 38-100°C, and nuclear substance in the activator amounts to 5-200 ml/l. The result is improved clinical HIFU therapy potential in cancer cells removal without affecting healthy tissues within the ultrasound path.
EFFECT: invention discloses application of fluocarbon emulsion activator for HIFU therapy in the course of HIFU therapy.
16 cl, 6 ex, 1 tbl
SUBSTANCE: present invention discovers a disperse activator for high-intensity focused ultrasound therapy (HIFUS therapy). The activator comprises a disperse phase consisting of a nucleus material encapsulated with a membrane-forming material, and a dispersive phase consisting of the aqueous medium. The disperse phase is regularly dispersed in the dispersive phase, while the particle size of the disperse phase is within 0.1-8 mcm; amount of the membrane-forming material in an activator is 0.1-100 g/l; the nucleus material consists of liquid not undergoing a liquid-gas transition within 38-100°C, and amount of the nucleus material in the activator is 5-200 g/l. According to the present invention, the disperse activator for HIFUS therapy can change considerably the acoustic environment in position of a target with improving deposition of acoustic energy in position of a target during HIFUS therapy. Besides, the invention discovers application of the disperse activator for HIFUS therapy during HIFUS therapy.
EFFECT: essentially improved possibilities for clinical essentially improve in removing the malignant cells.
18 cl, 4 ex, 4 tbl
SUBSTANCE: invention refers to method of production of lyophilised matrixe and, when restored, related injectable contrast medium containing liquid aqueous gas-filled microvoid suspension mainly phospholipid stabilised. Method includes preparation of emulsion based on aqueous environment, phospholipid and water-immiscible organic solvent. Then emulsion is dried with sublimation and restored to aqueous gas-filled microvoid suspension.
EFFECT: suspensions contain microvoids of relatively small diameter and narrow size distribution.
36 cl, 12 tbl, 16 ex
FIELD: medicine; ultrasonic diagnostics.
SUBSTANCE: clinical research is conducted to develop specific medicine forms using polymer microspheres with inserted perfluorocarbon. Medicine forms include microspheres of biologically compatible polymer, preferably with lipids incorporated in polymer, and containing perfluorocarbon, which transits to gaseous form at human body temperature. Patient receives microspheres in effective amount for improvement of ultrasonic imaging of ventricle chambers for longer than 5 minutes, dosage varying from 0.025 to 8.0 mg of microspheres per kg of body weight. Preferable dosage varies from 0.05 to 4.0 mg of microspheres per kg of body weight. Medicine form is usually stored in ampoule. Medicine in dry powder form is recovered with sterile water before application by adding water to ampoule or syringe and shaking it to obtain isosmotic or isotonic microsphere suspension.
EFFECT: improved image of ultrasonic imaging of cardiovascular area for long time period.
33 cl, 5 tbl, 5 ex
FIELD: medical instrument making, possibly non-invasive determination of temperature of biological objects inside living organism.
SUBSTANCE: method comprises steps of introducing to blood of investigated patient of echo-contrast matter; generating ultrasound pulse signals; receiving and converting echo-signal reflected from investigated organ of patient to electric signals; determining amplitude values of electric signals; separating spectrum zone of reflected acoustic signal; displaying image of investigated organ of patient. At step of preparation for investigation, temperature of sample of echo-contrast matter including gas-filled micro-bubbles is lowered till its least value in investigated temperature range and said sample is irradiated with ultrasound signal. Reflected echo-signals are converted to electric ones and signal with maximum amplitude is separated. Then concrete value of frequency of converted electric signal is measured and registered. Code electric signal corresponding to said frequency value is formed and stored. Sample is scanned at predetermined pitch and procedure of frequency measuring of converted electric signal is repeated. Then temperature of sample is changed by predetermined temperature pitch and measurements are repeated. At investigating patient according to preset scanning mode, wide-band pulse signal is generated; in spectrum of said wide band signal components of temperature signal spectrum are included while each received reflected echo-signal is converted to electric signal. Simultaneously with formation of image signal, in addition spectrum zones are separated corresponding to resonance frequencies of echo-contrast matter; amplitude values of respective signals are compared, electric signal with maximum amplitude is selected, frequency value corresponding to it is measured. Then code signal is formed and it is compared with reference code signals. At their coincidence respective temperature value is appropriated to respective spot of mage of investigated organ of patient. Apparatus for performing the method includes ultrasound converter connected through line- switching unit to unit for forming J acoustic lines; image signal receiver connected with scanning converter; memory circuit; comparator; calculation unit and monitor. Apparatus includes in addition K-stage regulator of temperature of thermostat for placing sample of echo-contrast matter; frequency meter; receiver having J units of N-duct filters, detectors and integrators connected in series; J units for selecting maximum-amplitude signals and
EFFECT: enlarged functional possibilities of method and apparatus.
2 cl, 4 dwg
SUBSTANCE: method involves a complex ultrasonic examination by means of Toshiba Aplio XG V4 ultrasonic apparatus. ASQ technique is used to construct a calculus density diagram to determine a density index. If the calculus density index is more than 5.5, an extracorporeal lithotripsy session is conducted at shock wave pulse 14-15 kV. If the calculus density index falls within the range of 5.5 to 3.6, the extracorporeal lithotripsy session is conducted at shock wave pulse reduced to 12-13 kV. If the calculus density index decreases to 3.5 to 2.0, the extracorporeal lithotripsy session is terminated.
EFFECT: method enables providing the more accurate control of renal calculi disintegration by determining its structural density that enables reducing the number of renal parenchyma injuries and a probability of complications.
4 dwg, 2 ex