Oil protective composition

FIELD: chemistry.

SUBSTANCE: invention relates to application of composition, which contains Polygonum aviculare grass 20-25 wt %, cowberry leaves 13-17 wt %, Viburnum sargentii koehne fruits 5-9 wt %, fruits of dog-rose of different of Far-East species 20-25 wt %, Schisandra chinensis seeds 13-17 wt %, Fragaria orientalis leaves 5-9 wt % and corn stigmas 5-9 wt %, as means with oil protective activity in treatment of glomerulonephritis.

EFFECT: invention provides positive influence on basic indices of glomerulonephritis: promotes recovery of diuresis, reduction of proteinuria, reduction of azotemia, cryoglobulinemia and level of circulating immune complexes.

2 tbl

 

The invention relates to medicine, namely to pharmacology, pharmacognosy, namely, to the creation of vegetable origin that can be used as a nephroprotective funds for non-infectious chronic inflammation of the kidneys, namely glomerulonephritis.

The closest analogue prototype is a drug of plant origin, the composition of which per 100 g of the solution is the centaury grass 0.6 g, lovage medicinal roots 0.6 g, rosemary leaves 0.6 g, purified water 71,0 g, the ethanol content of 16.0 to 19.5% in volume ratio called Canephron N, the solution for the reception inside (instructions for use of the medicinal product for medical use. Bionorica. Canephron N. Reg. No P N014244/01).

The disadvantage of this herbal preparation are possible dyspepsia: nausea, vomiting, diarrhea, and the ethanol content limits the use of drugs in a number of diseases: alcoholism, liver disease, traumatic brain injury, brain disease, stomach ulcer and duodenal ulcer in the acute stage, the children's age. In addition, during drug treatment should drink plenty of fluids that are contraindicated in violation of the functions of the heart or kidney and high blood pressure�attachment.

The goal is to offer a composition of medicinal plants, which will not have an adverse action, as in the prototype, and will expand the base used medicinal plants.

The technical result is expressed nephroprotective effect in the treatment of glomerulonephritis.

The technical result is achieved in that the composition with a marked nephroprotective effect constitute from medicinal plants growing in the Far East under natural conditions in the following proportions in wt.%:

knotweed grass20-25
cowberry leaves13-17
Kalina of Sargent fruit5-9
rosehip miscellaneous
far Eastern species of the fruit20-25
schisandra chinensis seeds13-17
sheet strawberry East5-9
corn silk5-9

The study was performed on rats male line BD-9 Dark Agouty Massey-180 g On the model of experimental glomerulonephritis Hey-Mann studied specific nephroprotective activity of the composition.

Studies have shown improvement depurazione renal function, restoration of diuresis, reduction of erythrocyturia, displacement reaction of urine in the direction of increasing pH, reduction of swelling stroma, patellectomy capillaries, a decrease in tubular degeneration and leukocyte infiltration. There was a definite dose-response relationship nephroprotective activity of the composition and revealed good tolerance. The most active composition was acting as an infusion at a dose of 20 ml/kg for 28 days.

Based on the analysis of the obtained data it was found that the nephroprotective action of the composition is realized through reducing the severity of autoimmune processes in the glomeruli of the kidney Table.1, namely nephroprotective composition reduced immunological and biochemical parameters compared to control: the level of circulating immune complexes, cryoglobulins, creatinine, urea. Proteinemia also significantly decreased, indicating that improvement depurazione renal function when using this collection. Nephroprotective composition operates through the normalization of urodynamics Table.2.

Thus, nephroprotective composition positively influenced �and key indicators of glomerulonephritis: contributed to the restoration of diuresis, reduction of proteinuria, reduce azotemia, Criollo-bulinemia and the level of circulating immune complexes. In General, the studied composition is not inferior nephroprotective activity prototype Canephron, and on a number of indicators exceeded.

The advantages of the present composition:

- does not cause dyspeptic reactions from the gastrointestinal tract;

- does not require the use of large amounts of fluid;

- you can use a wider range of patients, including children;

- plants do not require special growing;

- plants are more active, as they grow in natural conditions, namely, Chinese Magnolia, rose Daur, echinated, wrinkled, Maksimovic, Ussuri, strawberry East, Kalina of Sargent are endemic in the Far East;

- the composition has a pleasant odor and taste;

- possible use in the treatment of any infectious chronic inflammatory diseases of the kidneys;

- does not contain ethyl alcohol.

Table 1
The nephroprotective effect of composition on the biochemical and immunological blood parameters in glomerulonephritis
Group/drugCEC, %KG, CL. OP×100Creatinine, mm/lUrea, mmol/lTotal protein, g/l
11th knots
Group intact-10-140.6 to 1.449-594,1-4,568 to 80
tion of rats
The group con28-36*3,9-4,9*98-114*7,3-7,7*51-59*
Control rats
Cameron N, 3.0 ml/kg25-33*2,6-3,8*85-99*6,2-6,6*53-59*
NC, 5.0 ml/kg 24-36*2,8-3,4*87 through 105*Between 6.5-7.3*47-65*
NC, 20.0 ml/kg24-30*3,8-4,2*87-101*6,4-7,0*53-61*
28 days
Group intact5-150,4-1,457-653,4-4,471-79
tion of rats
The group con43-51*5,5-6,7*167-181*8,7-9,1*29-35*
control rats
Camefrom N, 3.0 ml/kg16-28*/**2,7-3,1*7**9-111*/** 4,7-5,3**61-71**
NC, 5.0 ml/kg28-38*/**5,5-6,1*111-121*/**5,7-6,1**47-55**
HK, 20.0 ml/kg14-26*/**1,7-2,7*/**75-91*/**5,3-5,9**63-69**

where the CEC circulating immune complexes,

KG - cryoglobulins,

NC - nefroprotektornoy composition,

* - differences are significant but compared to intotime, p<0.05, and

** - significant differences compared with control, p<0,05.

Table 2
The influence of infusion nephroprotective songs in excretory renal function in glomerulonephritis
Group/drugDiuresis, % 01 load/4 hoursProtein, g/lErythrocytes, cells./µlPCE G/mg protein
The group con88-980,25-0,35 0-50,09-0,17
control rats
The group con26-38*2,41-3,09*370-470*2,06-2,28*
control rats
Canephron N, 3.0 ml/g69-77*/**0,52-0,72*/**12-38*/**0,93-1,25*/**
NC 5.0 ml/kg47-61*/**1,52-l,77*/**47-53*/**2,08-2,28*
NC 20.0 ml/kg64-74*/**0,72-0,84*/**15-35*/**1,56-1,74*/**

where PCE - pseudocholinesterase,

NC - nephroprotective composition,

* - ogliche significant compared to ipcache, p<0.05, and

** - significant differences compared with control, p<0,05.

The use of compositions containing th�CA bird grass 20-25 wt.%, cowberry leaves 13-17 wt.%, viburnum Sargenti the fruits of 5-9 wt.%, hips different far Eastern species of the fruits of 20-25 wt.%, schisandra chinensis seeds 13-17 wt.%, strawberry leaves East 5-9 wt.%, corn silk 5-9 wt.%, representing the infusion of these raw materials as a means with nephroprotective activity in the treatment of glomerulonephritis.



 

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1 tbl, 2 ex

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8 cl, 4 tbl, 2 dwg, 4 ex

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