Method for producing vitamin nanocapsules in konjac gum

FIELD: medicine.

SUBSTANCE: cores of nanocapsules are vitamins, konjac gum precipitated from an isopropanole suspension by 1,2-dichlorethane added as a non-solvent and dried at room temperature.

EFFECT: simplifying and accelerating the process of nanoencapsulation, reducing accompanying loss, and higher weight yield.

7 ex

 

The invention relates to the field of nanotechnology, medicine and food industries.

Previously known methods for producing microcapsules.

In us Pat. 2173140, IPC AC 009/50, AK 009/127 Russian Federation, published 10.09.2001, a method of producing kremnijorganicheskih microcapsules using a rotary cavitation equipment with high shear forces and powerful hydroacoustic phenomena sonic and ultrasonic range for dispersion.

The disadvantage of this method is the use of special equipment - rotary-cavitational installation, which has the ultrasonic effect, which influences the formation of the microcapsules and thus may cause adverse reactions due to the fact that ultrasound has a destructive effect on polymers of protein nature, therefore, the proposed method is applicable when working with polymers of synthetic origin

In us Pat. 2359662, IPC AC 009/56, A61J 003/07, B01J 013/02, A23L 001/00 published 27.06.2009, Russian Federation, proposed a method of obtaining microcapsules of sodium chloride with the use of spray cooling in the spray tower Niro under the following conditions: air temperature at the inlet 10°C, the temperature at the outlet 28°C, the speed of rotation of the spray drum 10000 rpm/min Microcapsules according to the invention obl�give improved stability and provide adjustable and/or prolonged release of the active ingredient.

The disadvantages of the proposed method are the duration of the process and the use of special equipment, certain set of conditions (the air temperature at the inlet 10°C, the temperature at the outlet 28°C, the speed of rotation of the spray drum 10000 rpm/min).

The closest method is the method proposed in us Pat. 2134967, IPC A01N 53/00, A01N 25/28, published 27.08.1999, Russian Federation (1999). In water dispersed solution of a mixture of natural lipids and PYRETHROID insecticide in a weight ratio of 2-4:1 in an organic solvent, which leads to simplification of the method of microencapsulation.

The disadvantage is the dispersion in an aqueous medium, which makes the proposed method applicable for obtaining microcapsules of water-soluble drugs in water-soluble polymers.

The technical objective is the simplification and acceleration of the process of producing nanocapsules, reduction of losses in obtaining nanocapsules (increase of the yield by weight).

The solution of a technical problem is achieved by a method of obtaining nanocapsules vitamins, characterized in that as the shell of the nanocapsules used konjac gum, and as the kernel - vitamins (A, C, D, E, Q10), as well as extracts of ginseng and Eleutherococcus upon receipt of nanocapsules by deposition of nerastvorim with the use of 1,2-dichloroethane as the OS�makers, the process of obtaining nanocapsules can be made without special equipment.

A distinctive feature of the proposed method is to obtain nanocapsules by deposition of nerastvorim using 1,2-dichloroethane as a precipitant, and the use of Konakova gum as the shell particles and vitamins - as the kernel.

The result of the proposed method are obtaining nanocapsules of vitamins A, C, D, E, Q10and extracts of ginseng and Eleutherococcus.

EXAMPLE 1. Obtaining nanocapsules of vitamin A in Konakovo gums, the ratio of core:shell 1:3

100 mg of vitamin A are added to a suspension of Konakova gum isopropanol containing the specified 300 mg of the polymer in the presence of 0.01 g of the drug Is (an ester of glycerol with one or two molecules of dietary fatty acids and one or two molecules of citric acid, and citric acid as tribasic can be etherification other glycerides and as oxanilate - other fatty acids. Free acid groups can be neutralized with sodium) with stirring 1300 Rev/sec. Next, pour 2 ml of 1,2-dichloroethane. The resulting suspension was filtered and dried at room temperature.

Received 0,396 g of powder of nanocapsules. The yield was 99%.

EXAMPLE 2. Obtaining nanocapsules of vitamin C in Konakovo gums, �the rate of core:shell 1:3

100 mg of vitamin C was added to a suspension of Konakova gum isopropanol containing the specified 300 mg of the polymer in the presence of 0.01 g of the drug As with stirring 1300 Rev/sec. Next, pour 2 ml of 1,2-dichloroethane. The resulting suspension was filtered and dried at room temperature.

Obtained 0.4 g of powder of nanocapsules. The yield was 100%.

EXAMPLE 3. Obtaining nanocapsules of vitamin D in Konakovo gums, the ratio of core:shell 1:3

100 mg of vitamin D is added to a suspension of Konakova gum isopropanol containing the specified 300 mg of the polymer in the presence of 0.01 g of the drug As with stirring 1300 Rev/sec. Next, pour 2 ml of 1,2-dichloroethane. The resulting suspension was filtered and dried at room temperature.

Obtained 0.4 g of powder of nanocapsules. The yield was 100%.

EXAMPLE 4. Obtaining nanocapsules of vitamin E in Konakovo gums, the ratio of core:shell 1:3

100 mg of vitamin E added to a suspension of Konakova gum isopropanol containing the specified 300 mg of the polymer in the presence of 0.01 g of the drug As with stirring 1300 Rev/sec. Next, pour 2 ml of 1,2-dichloroethane. The resulting suspension was filtered and dried at room temperature.

Obtained 0.4 g of powder of nanocapsules. The yield was 100%.

EXAMPLE 5. Obtaining nanocapsules vitamin Q10in Konakovo gums, the ratio of the core:sheaths from her bouti�and 1:3

100 mg vitamin Q10in dimethylsulfoxide is added to a suspension of Konakova gum isopropanol containing the specified 300 mg of the polymer in the presence of 0.01 g of the drug As with stirring 1300 Rev/sec. Next, pour 2 ml of 1,2-dichloroethane. The resulting suspension was filtered and dried at room temperature.

Received 0,396 g of powder of nanocapsules. The yield was 99%.

EXAMPLE 6. Obtaining nanocapsules of ginseng extract in Konakovo gums, the ratio of core:shell 1:3

100 mg of ginseng extract is added to a suspension of Konakova gum isopropanol containing the specified 300 mg of the polymer in the presence of 0.01 g of the drug As with stirring 1300 Rev/sec. Next, pour 2 ml of 1,2-dichloroethane. The resulting suspension was filtered and dried at room temperature.

Obtained 0.4 g of powder of nanocapsules. The yield was 100%.

EXAMPLE 7. Obtaining nanocapsules of Eleutherococcus extract in Konakovo gums, the ratio of core:shell 1:3

100 mg of the extract of Eleutherococcus added to a suspension of Konakova gum isopropanol containing the specified 300 mg of the polymer in the presence of 0.01 g of the drug As with stirring 1300 Rev/sec. Next, pour 2 ml of 1,2-dichloroethane. The resulting suspension was filtered and dried at room temperature.

Obtained 0.4 g of powder of nanocapsules. The yield was 100%.

Method of encapsula�AI of the drug by the method of deposition by nerastvorim, characterized in that as the nuclei of the nanocapsules used vitamins, as the shell - konjac gum, which is deposited from suspension in isopropanol by adding as herstories 1,2-dichloroethane, followed by drying at room temperature.



 

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