Method for combination treatment of acute alcoholic hepatitis with organic selenitium and vitamin e
SUBSTANCE: integrated therapy additionally involves administering thin-walled Capsicum annuum powder of the type paprika in a dose of 30 g with the specified selenium contents of 1 mg/kg and a capsule of alpha-tocopherol acetate in a dose of 100 mg manufactured by Lyumi, LLC (Ekaterinburg) orally during meals 3 times a day. The length of the treatment is 20 days.
EFFECT: invention enables reducing the time of the treatment, increasing its efficacy, and prolonging remission.
1 tbl, 2 dwg, 2 ex
The invention relates to medicine, namely to Hepatology, and can be used in the treatment of alcoholic liver disease.
Alcohol abuse is considered the main aetiological factors of chronic liver disease in the world, including in Russia (Khazanov A. I., Vasiliev A. P., Pekhterev S. G. and other problems of etiological factors of liver cirrhosis in hospitalized patients (1992-2005): alcoholic cirrhosis comes out on top in number of patients and high mortality // Klin, gepatol. - 2006. - Vol. 2, No. 2. - P. 11-16). The relatively young age of those affected, their employment in socially useful work, prolonged hospital stay, the need for a long period of outpatient observation - all this makes the disease one of the most expensive in the clinic of internal diseases and shows significant damage alcoholic liver disease the industrial sector of the Russian Federation, as well as lack of effective therapy.
One of the ways-analogues for the treatment of acute alcoholic hepatitis is the use of corticosteroids (Chedid A., Mendenhall, C. L., Gartside P. Prognostic factors in alcoholic liver disease // Am. J. Gastroenterol. -2001. - Vol.12. - P. 23-29.). However, the disadvantage of this method is the limitation of its use in patients with severe alcoholic hepatitis for fear of infectious OS�of ogneni.
In recent times attempts have been made to evaluate the clinical effectiveness of the use of direct anti-cytokine drugs, particularly infliximab. However, the results of these studies do not allow one to evaluate the rationality of such approaches in the treatment of acute alcoholic hepatitis (Mureno G. N., Karlotti G., Giovani F. T. et al. Infliximab treatment among the patients with acute alcoholic hepatitis. A pilot study // Ital. J. Gastroenterol. Hepatol. - 2003. - Vol.10. - P. 24-29.).
Currently proven part of the processes of lipid peroxidation and selenium in the pathogenesis of acute alcoholic hepatitis (Rui M. Rua, M. L. Ojeda, F. Nogales et al. Serum selenium levels and oxidative balance as differential markers in hepatic damage caused by alcohol // Life Sciences, 17 January 2014, P. 158-163). Selenium is a structural component of the antioxidant enzyme glutathioneperoxidase. These provisions allow you to look at hepatocellular insufficiency decompensated hepatitis of alcoholic etiology as to the dynamic mismatch between the current needs of the organism in selenium and functionality of the liver, which appear in the indicators.
The method-analogue is the treatment of biologically active forms of inorganic selenium compounds containing Selenite or sodium selenate. However, Selenite and sodium selenate are not able to stock up in the body and should not be included in therapy inside�them diseases. In addition, if it is impossible to dispose of the excess selenide formed during the metabolism of these drugs, inorganic selenium can accumulate in the tissues of the body in the form of free hydrosilylation, which is extremely toxic.
Closest analogue is the prototype of the investigated method is the correction of selenium deficiency by taking in organic selenium in the form of BAD "Selenium-asset", "Antioxycaps with selenium" or in the form of hepatoprotective pharmaceutical composition patent for the invention of "hepatoprotective Pharmaceutical composition and method of treatment" No. 2391989 from 21.08.2008). However, the disadvantage taken with this method drugs is joint content of selenium per capsule vitamin C (ascorbic acid) and thioctic, greenexpo acids respectively, while the biologically active form of selenium is unstable and is rapidly reduced by the action of acids. Selenium should be taken separately with this group of chemicals, as they mutually inhibit the absorption of one another. In addition, there is a disadvantage that the drugs "Antioxycaps with selenium" and hepatoprotective pharmaceutical composition selenium dosage is below average for a healthy person is 30 mcg.
Organic animal form of selenium absorbed by 30%, n�organic form - 10% (Yu. V. Marushko, Ostapenko Y. Y. Role of selenium in clinical practice// children lcar - 2012. - No. 5. - P. 32-36). However, the most preferred for the body of a vegetative form of selenium because of its high digestibility (95-98%), therefore, most authors recommend this as the most preferred form in the body supplied with selenium. Therefore, the closest to the investigated method is the prototype of correction of selenium status by using powder of thin-walled sweet pepper varieties "lighthouse" tall paprika installed selenium 1 mg/kg in the dose of 50 g/d (application for the invention "Method of fotokorrektsii of selenium deficiency in humans" No. 2013138967/15 from 20.08.2013). The disadvantage of the claimed method is the daily dosage for an adult healthy person in terms of selenium is 50 ág/day, that does not account for the increased consumption of the trace element selenium in acute alcoholic hepatitis (L. A. Reshetnik, E. O. Lee, V. A. Rock. The daily requirement for selenium in healthy individuals // nutrition, 2000, vol. 47, No. 4, pp. 15-21). In addition to the above, selenium potentiates the antioxidant activity of vitamin E (tocopherol), activates glutathione together with vitamin E protects the cell membrane, mitochondria, microsomes and lysosomes from lipid peroxidation. On this basis, pathogenetically used�the use of selenium together with tocopherol, what is not in this version.
In the available literature, we have not met information about the combined use of selenium and tocopherol in the treatment of acute alcoholic hepatitis, their influence on the course of pathological process in the liver, and data routes of administration, dosages and regimens. Thus, the use of powder thin-walled sweet pepper varieties "lighthouse" tall paprika, enriched with selenium and tocopherol for the treatment of toxic liver diseases proposed by the authors for the first time.
The object of the invention is to improve the quality of complex therapy of alcoholic liver disease in the form of acute alcoholic hepatitis, devoid of the above drawbacks.
The technical result consists in the fact that the method of combined treatment of acute alcoholic hepatitis with organic selenium and vitamin E increases the duration of remission and helps to overcome the shortcomings of standard treatment regimens.
The technical result is achieved in that in the scheme of treatment along with standard integrated therapy (ursodeoxycholic acid 15 mg/kg/day orally, Essentiale N 5 ml/day intravenously) included a combination of two drugs: powder thin-walled sweet pepper varieties "lighthouse" tall paprika (Photo 1, Photo 2) installed selenium 1 mg/kg dozirovke 30 g per single dose and capsule, contains 100 mg of alpha-tocopherol acetate at one time the manufacturer LLC "Lumi" (Ekaterinburg). The introduction of both drugs is carried out orally during meal, 3 times a day, which provides the daily dose was reduced to 90 mcg selenium and 300 mg of alpha-tocopherol acetate. Course duration is 20 days. This pepper is grown with the use of NPK fertilizers of prolonged action Apionidae, containing 0.03% Na2SeO4(application for the invention "Method of enrichment of selenium pepper sweet paprika cultivar" No. 2012122267/13 dated 29.05.2012; Standard of Organization "Paprika, enriched with selenium. Industrial raw materials. Technological conditions" (one HUNDRED 45727225-37-2011) the Application to the application 1). The use of fertilizers of prolonged action APION, containing 0.03% Na2SeO4increases the accumulation of selenium in fruits 7.7 times, resulting in increased antioxidant activity of the powder, paprika 1.5 times compared with the control. Selenium in combination with tocopherol ensures optimal and sustained antioxidant protection, enhances the action of the main drugs.
The technical result was achieved in the treatment of 36 patients with an established diagnosis of acute alcoholic hepatitis of moderate severity". All cases were confirmed by clinical and laboratory methods. In the amount of complex therapy of 12 patients from gr�PPy 3 received powder thin-walled sweet pepper varieties "lighthouse" tall paprika installed selenium 1 mg/kg (powder paprika), a daily dose of 90 g of oral alpha-tocopherol acetate at a daily dose of 300 mg orally; 12 patients of group 2 received powder paprika in a daily dose of 50 g of oral. A comparison group consisted of 12 patients from group 1 who received only basic therapy. Dangerous side effects when using selenium at the dose of 50 μg, 90 μg and 200 mg of alpha-tocopherol acetate per day is not revealed. Statistical data processing was performed using Statistica v6.0 (StatSoft, USA).
The results of the study are shown in table 1, show that the duration of symptoms such as jaundice, itching, fever, abdominal pain compared groups differed significantly. The decrease in the concentration of total bilirubin, γ-glutamyl-transpeptidaza alkaline phosphatase of blood in the group treated with the drug selenium and tocopherol was significantly higher than in the 2nd and 1st teams. The level of selenium in blood serum in group 3 changed from mild forms of the disease (70-90 µg/l) until the optimal security of the body (116-130 µg/l). The inclusion of powder thin-walled sweet pepper varieties "lighthouse" tall paprika, enriched with selenium, and alpha-tocopherol acetate in the standard therapy helps to restore the processes of antioxidant protection in the form of decrease of glutathione peroxidase activity.
Length of bed-days in gr�PE patients receiving combined therapy with the powder paprika in a dose of 90 mcg/day and tocopherol, was significantly less than in the group of patients treated with powder paprika in a dose of 50 mg/day, and only the combined therapy.
The data obtained indicate that the proposed method has advantages in comparison with analogues:
- improves the clinical course of the disease;
- improves the bioavailability of selenium in the product;
- reduces the duration of hospital stay;
- improving the quality of life of patients;
- reduced diversion of patients from the performance of employment duties because of temporary disability;
- physiological method, chemically and psychologically safe for the patient;
- conducting the method does not require special knowledge among health care personnel.
The results of the research allowed us to make a number of promising conclusions about the advisability of further study and use of selenium in combination with vitamin E in the complex therapy of alcoholic liver disease.
Patient T., aged 58. In June 2013, hospitalized with complaints of yellowness of the skin, General weakness, swelling of feet observed for 1.5 months prior to admission. History of alcohol abuse for 7 years, daily doses when�imagelogo alcohol ranged from 200 to 300 ml in terms of 96% alcohol, before the advent of the above complaints drinking alcohol every day during the week. The Department conducted a complete laboratory and instrumental examination, and then diagnosed as acute alcoholic hepatitis of moderate severity, associated with liver cirrhosis grade C child-Pugh. The content of selenium in the serum of 56 ág/l (severe deficiency). Start therapy with 30 g of powder of thin-walled sweet pepper varieties "lighthouse" orally during meals 3 times a day, 100 mg of alpha-tocopherol acetate manufacturer LLC "Lumi" (Ekaterinburg) orally during meals 3 times a day, ursodeoxycholic acid 15 mg/kg/day orally, Essentiale N 5 ml/day intravenously, spironolactone 400 mg/day of oral and furosemide (100 mg/day intravenously; positive dynamics was observed: decreased pain in the abdomen, yellowness of the skin. After 20 days the drug of selenium and tocopherol have been completely eliminated, relapse was not observed. At follow-up after 32 days of clinical and laboratory remission, the level of selenium in serum 114 ág/l (suboptimal provision), the patient was discharged with a closed leaf of invalidity.
Patient E., 34 years. He considers himself a patient since April 18, 2013, when after a three-day alcohol use appeared �water, yellowness of the skin, pain in the epigastrium, was not treated. History of regular alcohol consumption is 12 years, daily doses taken alcohol ranged from 300 to 500 ml in terms of 96% alcohol. April 24, 2013 he began to notice the deterioration in the form of asthenic syndrome, turned to the physician and was referred to the hospital. After execution of laboratorial screening patient diagnosed with acute alcoholic hepatitis of moderate severity, associated with cirrhosis of the liver, In class on child-Pugh. The content of selenium in the serum of 93 ág/l (mild deficiency). Start therapy with 30 mg of powder of thin-walled sweet pepper varieties Mayak, orally during meals 3 times a day, 100 mg of alpha-tocopherol acetate manufacturer LLC "Lumi" (Ekaterinburg) orally during meals 3 times a day, ursodeoxycholic acid 15 mg/kg/day orally, Essentiale N 5 ml/day intravenously, positive dynamics was observed: decreased jaundice, pain in the abdomen. After 20 days the drug of selenium and tocopherol have been completely eliminated, relapse was not observed. At the control examination after 24 days of clinical and laboratory remission, the level of selenium in the serum of 129 ág/l (optimal security).
The method of combined treatment of acute alcoholic hepatitis with organic selenium and vitamin E, characterized in that in the active stage of the disease is taken orally during meal powder thin-walled sweet pepper varieties "lighthouse" tall paprika installed selenium 1 mg/kg alpha-tocopherol acetate manufacturer LLC "Lumi" (Ekaterinburg), respectively, at doses of 30 mg and 100 mg single dose, 3 times a day for 20 days, which allows for early clinical effect, to restore the antioxidant defense processes and improve the bioavailability of trace elements.
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention relates to therapeutic or preventive means in case of disease(s) of biliary tracts, which are caused or are aggravated by sphincter of Oddi contraction. As effective component, claimed means contains compound, presented by general formula
In formula (I) double line, which contains from dotted line and solid line, represents double bond or single bond, R1 represents C4-C7-cycloalkylalkyl, R2 represents linear or branched C1-C5-alkyl, and B represents - CH=CH-.
EFFECT: invention also relates to compound of formula (I) and to method of treatment or prevention in case of disease(s) of biliary tracts, which are caused or intensified by sphincter of Oddi contraction.
6 cl, 1 dwg, 1 ex
SUBSTANCE: using dense extract of cowslip primrose (Primula veris L.) herb as a hepatoprotective agent.
EFFECT: agent is effective as a hepatoprotector.
SUBSTANCE: drops possessing antiviral and immunomodulatory effects characterised by the fact that they represent a 95% ethanol infusion of wild strawberry leaves and fruit specified in: red raspberry fruit, mountain ash fruit, bilberry fruit, blood-red hawthorn fruit, cinnamon rose fruit; 15-25 mg of the substance in 1 ml of the infusion.
EFFECT: drops possess pronounced antiviral and immunomodulatory effects.
15 tbl, 5 ex
SUBSTANCE: wound canal is packed with a preparation of recovered oxygenated cellulose. Thereafter in an entrance wound, the preparation is exposed to 2 cycles of cryotherapy with liquid nitrogen at a temperature of minus 196°C for 1-2 minutes until an ice crust is formed on the wound surface.
EFFECT: method provides excluding the possibility of bleeding and bile flowing from an inner surface of stab wounds, reducing a risk of recurrent bleedings, formation of liver haematomas postoperatively.
3 dwg, 2 tbl, 2 ex
SUBSTANCE: conducting No. 5 dietary therapy and doing therapeutic exercises are prescribed. That is combined with taking low-mineralised carbonated sodium calcium chloride hydrogen carbonate sulphate mineral water "Essentuki Novaya" at 3.5 ml per 1 kg of patient's body weight 30-40 minutes before meals; 2% pentoxiphyline full-length ampli-pulse-phoresis procedures are performed daily with an anode placed on a projection of liver, whereas a cathode is placed symmetrically on back in the III and II operation modes (6 minutes each), at modulation frequency 150 Hz, modulation depth 75%; the therapeutic course includes 10 procedures.
EFFECT: method enables reducing the length of treatment and increasing the clinical effectiveness.
5 tbl, 2 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: what is presented is a group of inventions concerning a new application of bicyclo[2,2,2]octane-2-carboxylic acid salt. What is presented is using it for treating dysphoria in a person suffering epilepsy for treating alcohol addiction, for reducing the level of hepatic function marker specified in AST (aspartate aminotransferase), ALT (alanine aminotransferase) or bilirubin in the person for reducing an erythrocyte sedimentation rate, as well as for reducing a number or an intensity of epileptic attacks in a daily dose of min 400 mg.
EFFECT: implementing the above applications with no negative effect on patient's behaviour and the functions of the main organs and systems.
19 cl, 6 tbl, 2 ex
FIELD: food industry.
SUBSTANCE: method for production of Siberian cedar seeds liqueur (with hepatoprotective, antioxidant, antihypoxic, hypolipidemic effect) by way of maceration with ethyl alcohol usage; whole Siberian cedar seeds are loaded into the reactor, poured with 70% ethyl alcohol water solution; extraction is performed under preset conditions. The medicinal preparation with hepatoprotective, antioxidant, antihypoxic, hypolipidemic effect contains Siberian cedar seeds liqueur. Usage of the medicinal preparation as a hepatoprotective remedy.
EFFECT: liqueur has pronounced hepatoprotective, antioxidant, antihypoxic and hypolipidemic effect.
6 cl, 3 dwg, 8 tbl
FIELD: medicine, pharmaceutics.
SUBSTANCE: present invention refers to chemotherapy of cancer and represents a composition for hepatic cancer in individuals and containing a complex of formula [M(RCS3)2(RCS2)], wherein M represents 188Re having an activity of more than 3.7 GBq and a lipophilic organic phase emulsified with a water phase; as well as a method for preparing the above composition.
EFFECT: invention provides higher stability and efficacy of the composition for treating hepatic cancer in the individuals.
17 cl, 1 dwg, 9 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to the pharmaceutical industry, particularly to a composition for treating or preventing the human immunodeficiency virus (HIV) or hepatitis C. The herbal composition used for treating or preventing the patients infected by the HIV or hepatitis C viruses and containing a herbal ingredient with tannin agents and catechin, and a pharmaceutically acceptable carrier; the herbal ingredient is Agrimonia Eupatoria (GAFT) and/or gambier (Uncaria gambir). A method for preparing the herbal composition for treating or preventing the patients infected by the HIV or hepatitis C viruses.
EFFECT: composition is effective for treating or preventing the patients infected by the HIV or hepatitis C viruses.
12 cl, 6 dwg, 2 tbl
SUBSTANCE: group of inventions refers to medicine, namely to hepatology and neurology, and can be used for using rifaximin for preparing a drug preparation for maintaining hepatic encephalopathy (HE) remission in a subject. That is ensured by daily administration of rifaximin into the subject for approximately 12 months or more, or approximately 1095 days or longer, thereby maintaining the HE remission.
EFFECT: group of inventions provides the stable HE remission, as well as a low antibiotic resistance of the patient's bacterial flora.
16 cl, 34 dwg, 28 tbl, 6 ex
SUBSTANCE: group of inventions relates to medicine. Described is a wet product from a non-woven material, soaked with a substance for personal hygiene, which is applied in household or for local processing for medicinal purposes. The non-woven material represents a bonded fibrous cloth, possessing hydrophilic properties, or a fibrous cloth, to which hydrophilic properties have been applied by processing with moisturising additives.
EFFECT: wet product possesses the high absorbing property and increased ability of releasing a substance, possessing the absorbing ability, and its transfer onto the surface.
21 cl, 3 tbl
SUBSTANCE: invention refers to dentistry, namely represents an encapsulated oral care composition and an oral care device. According to the invention, the composition contains: (a) a gelatine capsule; and (b) an oral care composition inside the capsule and containing: (i) a hydrophilic active ingredient, (ii) a hydrophobic structuring ingredient, and (iii) an oil carrier. The hydrophilic active ingredient preferentially represents cetylpyridinium chloride. The hydrophobic structuring ingredient preferentially represents gelated mineral oil.
EFFECT: developing the composition according to the invention solves the problem of cetylpyridinium chloride migration and fish-eye capsule defect.
9 cl, 1 ex, 1 tbl
SUBSTANCE: claimed invention relates to cosmetic field, namely represents method of colouring or lightening of keratin fibres, which includes stage of mixing without preparation at the moment of application of two compositions (A) and (B) and application of said mixture on said fibres; with said mixture including, at least, 25% of fatty substances relative to the total weight of composition, obtained in mixing two compositions (A)+(B).
EFFECT: method by invention makes it possible to produce intensive and uniform colouring of keratin fibres, with method simultaneously being easy to realise, because mixture in form of oil-reach emulsion does not flow down, but remains on application place, as well as makes it possible to lighten keratin fibres.
19 cl, 3 tbl, 1 ex
SUBSTANCE: shower gel comprises lauryl glucoside, sodium carboxylate and lauryl glucoside, coco glucoside, cocon amidopropylbetaine, guar-hydroxypropyltrionium chloride, coco glucoside and glyceryl oleate, ethyl alcohol, a fragrance component, sanguinitrine derived from small-fruited plumepoppy, citric acid and water. The components of the gel are in a certain ratio in wt %.
EFFECT: invention provides high washing and foam-generating capacity with soft action which does not disturb the lipid layer of the skin and has a disinfecting action, without destroying own microflora of human skin.
FIELD: medicine, pharmaceutics.
SUBSTANCE: group of inventions relates to liposomal compositions for application in cosmetic industry, including i) from 0.001 to 1 wt % of cyclo-(Arg-Gly-Asp-DPhe-Acha) and/or its salt or solvate, ii) from 0.01 to 20 wt % of one or more lipids; iii) from 60 to 99.99 wt % of one or more physiologically acceptable solvents, as well as to method of their obtaining and application for care and preservation of general condition of skin or hare, for prevention or reduction of wrinkles.
EFFECT: claimed compositions demonstrate favourable properties: improved effectiveness, higher stability, reduced immunogenic reactions in comparison with known properties.
18 cl, 3 dwg, 29 tbl, 18 ex
SUBSTANCE: present invention relates to cosmetology and hygiene and provides a foaming detergent composition which contains: a) surfactants consisting of decyl glucoside and coco glucoside, where the decyl glucoside is present in an amount by weight which is 1.8 to 2.2 times the weight of coco glucoside, and b) water, where the amount of decyl glucoside is 10 to 30 wt % of the composition, wherein the composition is free of anionic surfactants.
EFFECT: invention enables to produce a detergent composition having foaming properties in the absence of an anionic surfactant that are equally effective as with a composition with an anionic surfactant.
23 cl, 6 ex
SUBSTANCE: invention is the biological means for cleaning and restoration of skin, comprising pancreatic tissue of pigs or birds, 70% ethyl alcohol, fragrance component, and Ringer's solution, at that the components in the means are in a certain ratio, in wt %.
EFFECT: acceleration of the process of skin regeneration, expanding of range of means having cleaning and skin restoring action.
3 dwg, 1 tbl
SUBSTANCE: implementing the presented method involves mixing gel Hyaludent 1 ml on a slide with Betaleukin 0.0005 ml dissolved in water for injections 1 ml; the produced content is applied with a single application syringe on a desalivated treated area of the involved periodontal tissues and left until completely absorbed for 1-3 minutes; the involved area is exposed to laser light generated by the laser semiconductor dental therapeutic apparatus Optodan with a periodontal tip in the mode II, with the exposure length for 3-5 minutes; the therapeutic course is 8 days daily.
EFFECT: using the method enables achieving the fast regeneration length, ensuring the intact periodontal state in the most patients.
4 tbl, 3 ex
SUBSTANCE: invention aims at treating drug-induced dry eye syndrome (DI-DES). Treating DI-DES implies taking the past medical history, measuring tear production and eye xerosis values reduced and increased respectively in relation to the norm. Unpreserved ocular hypotensive medications are prescribed in the patient. Unpreserved artificial tears are also applied. The lachrymal fluid is analysed by a multicytokine technique. If the analysis shows increased concentrations of proinflammatory cytokines - interleukin-6, interleukin-8, interleukin-12, Th-1 - interleukin-2, interferon-gamma, and Th-2 - interleukin-4, by min 30% in relation to the patient's age norm, a chronic immune ocular inflammation is detected. That requires transpalpebral Blepharogel-1 phonophoresis and 1% hydrocortisone ointment phonophoresis on the sub-mastoidal region from both sides; the therapeutic course is 8-10 daily procedures.
EFFECT: optimal conditions for diagnosing and reasoned differentiated therapy of DI-DES that enables prescribing the pathogenetically reasoned therapy in due time and increasing the efficacy of the therapeutic exposure.
1 tbl, 2 ex
SUBSTANCE: invention represents an agent for treating a pulp inflammation differing by the fact that it contains Bezornil ointment and Dycal ivory paste in ratio 1:1 blended until smooth.
EFFECT: invention provides relieving oedema and pain on the day of doctor's appointment, accelerating the pulp tissue regeneration process, creating the reparative dentin within 30 days, and ensures the higher clinical effectiveness in the pulp inflammations.
2 ex, 1 tbl
SUBSTANCE: invention relates to field of encapsulation, in particular to method of obtaining microcapsules of vitamins A, C, E or Q10 in coating from highly etherified or low etherified apple or citrus pectin. In accordance with method by invention preparation E472c is added to suspension of highly etherified or low etherified apple or citrus pectin in ethanol and mixed. After that, suspension of vitamin in dimethylsulphoxide is added to suspension of pectin in ethanol, with further addition of benzene and distilled water. Obtained suspension of microcapsules is filtered and dried. Process of obtaining microcapsules is realised at 25°C for 15 min.
EFFECT: invention provides simplification and acceleration of process of obtaining microcapsules, reduction of loss in the process of their obtaining (increase of output by weight).