Method of obtaining microcapsules of antioxidants in pectin

FIELD: chemistry.

SUBSTANCE: invention relates to field of encapsulation, in particular to method of obtaining microcapsules of vitamins A, C, E or Q10 in coating from highly etherified or low etherified apple or citrus pectin. In accordance with method by invention preparation E472c is added to suspension of highly etherified or low etherified apple or citrus pectin in ethanol and mixed. After that, suspension of vitamin in dimethylsulphoxide is added to suspension of pectin in ethanol, with further addition of benzene and distilled water. Obtained suspension of microcapsules is filtered and dried. Process of obtaining microcapsules is realised at 25°C for 15 min.

EFFECT: invention provides simplification and acceleration of process of obtaining microcapsules, reduction of loss in the process of their obtaining (increase of output by weight).

16 ex

 

The invention relates to the field of microencapsulation of antioxidants in Apple and citrus pectin (high and nizkotemeraturnom) physico-chemical method.

Previously known methods for producing microcapsules of drugs. So, in us Pat. 2092155, IPC A61K 047/02, A61K 009/16 published 10.10.1997, Russian Federation, proposed a method for microencapsulation of drugs, based on the use of special equipment use of irradiation with ultraviolet rays.

The disadvantages of this method are the duration of the process and application of ultraviolet radiation, which can influence the formation of microcapsules.

In us Pat. 2095055, IPC A61K 9/52, A61K 9/16, A61K 9/10, Russian Federation, published 10.11.1997, a method of producing a solid non-porous microspheres comprises melting pharmaceutically inactive substance carrier, the dispersion of the pharmaceutically active substance in the melt in an inert atmosphere, spraying the resulting dispersion in the form of a mist in the freezing chamber under pressure, in an inert atmosphere, at a temperature of from -15 to -50°C, and separation of the obtained microspheres into fractions by size. The suspension is intended for administration by parenteral injection, contains an effective amount of microspheres distributed in Pharma�automatically acceptable liquid vector, and the pharmaceutically active substance insoluble microspheres in a specified liquid medium.

Disadvantages of the proposed method are the complexity and duration of the process, the use of special equipment.

In us Pat. 2091071, IPC A61K 35/10, Russian Federation, published 27.09.1997, a method of producing the drug by dispersing in a ball mill to obtain microcapsules.

The disadvantages of this method are the use of the ball mill and the duration of the process.

In us Pat. 2076765, IPC B01D 9/02, Russian Federation, published 10.04.1997, a method of producing dispersed particles of soluble compounds in the microcapsules by means of crystallization from solution, wherein the solution is dispersed in an inert matrix, cooled and, by changing the temperature, get dispersed particles.

The disadvantage of this method is the complexity of: obtaining microcapsules by dispersing followed by a change in temperature, which slows down the process.

In us Pat. 2101010, IPC A61K 9/52, A61K 9/50, A61K 9/22, A61K 9/20, A61K 31/19, Russian Federation, published 10.01.1998 proposed chewable form of the drug with taste masking, having the properties of a controlled release drug product that contains microcapsules with a size of 100-800 microns in diameter and consists of pharmaceutical kernel with Cree�metal ibuprofen and polymeric coatings comprising a plasticizer, elastic enough to resist chewing. Polymer coating is a copolymer based on methacrylic acid.

Disadvantages of the invention: use of a copolymer based on methacrylic acid, as these polymer coatings can cause cancer; obtaining microcapsules by the method of suspension polymerization; the difficulty of execution; the duration of the process.

In us Pat. 2139046, IPC A61K 9/50, A61K 49/00, og 51/00 A61K, Russian Federation, published 10.10.1999, a method of producing microcapsules as follows. Emulsion oil-in-water is prepared from an organic solution containing dissolved mono-, di-, triglyceride, preferably of tripalmitin or tristearin, and perhaps therapeutically active substance, and an aqueous solution containing a surfactant may evaporate the solvent, add redispersible agent, and the mixture is subjected to drying by freezing. Subjected to drying, the mixture is then dispersed in an aqueous medium to separate the microcapsules from the remnants of organic matter and a hemispherical or spherical microcapsules are dried.

The disadvantages of the proposed method are the complexity and duration of the process, the use of drying by freezing, which takes a lot of lies�and slows down the process of obtaining microcapsules.

In us Pat. 2159037, IPC A01N 25/28, A01N 25/30, Russian Federation, published 20.11.2000, a method of producing microcapsules by polymerization reaction at the phase boundary, containing solid agrochemical material of 0.1 to 55 wt.%, suspended in a stirred water organic liquid, from 0.01 to 10 wt.% non-ionic dispersant, is active on the interface and not acting as an emulsifier.

Disadvantages of the proposed method are the complexity, duration, use of vysokokalievogo mixer.

In us Pat. 2173140, IPC A61K 009/50, A61K 009/127, Russian Federation, published 10.09.2001, a method of producing kremnijorganicheskih microcapsules using a rotary cavitation equipment with high shear forces and powerful hydroacoustic phenomena sonic and ultrasonic range for dispersion.

The disadvantage of this method is the use of special equipment - rotary-cavitational installation, which has the ultrasonic effect, which influences the formation of the microcapsules and thus may cause adverse reactions due to the fact that ultrasound has a destructive effect on polymers of protein nature, therefore, the proposed method is applicable when working with polymers of synthetic origin.

In us Pat. 2359662, IPC A61K 009/56, A61J 003/07, B01J 013/02, A23L 001/00 posted on other sites.� 27.06.2009, The Russian Federation proposed a method of producing microcapsules using spray cooling in the spray tower Niro under the following conditions: air temperature at the inlet 10°C, the temperature at the outlet 28°C, the speed of rotation of the spray drum 10000 rpm/min Microcapsules according to the invention have improved stability and provide adjustable and/or prolonged release of the active ingredient.

The disadvantages of the proposed method are the duration of the process and the use of special equipment, certain set of conditions (the air temperature at the inlet 10°C, the temperature at the outlet 28°C, the speed of rotation of the spray drum 10000 rpm/min).

In us Pat. WO/2010/076360 ES, IPC B01J 13/00; A61K 9/14; A61K 9/10; A61K 9/12 published 08.07.2010, we propose a new method for obtaining solid micro - and nanoparticles with a homogeneous structure with a particle size less than 10 microns, where the treated solids have a natural crystalline, amorphous, polymorphous, and other conditions associated with the reference compound. The method allows to obtain solid micro - and nanoparticles with substantially spheroidal morphology.

The disadvantage of the proposed method is the complexity of the process that results in capsules with a floating output.

In us Pat. WO/2010/119041 EP, IPC A23L 1/00 posted on other sites.� 21.10.2010, a method of producing microspheres comprising an active component encapsulated in the gel matrix whey protein, including denatured protein, the serum and active components. The invention relates to a method of producing microspheres, which contain components such as probiotic bacteria. A method of producing microspheres includes the step of production of microspheres in accordance with the method of the invention and the subsequent solidification of microspheres in a solution of anionic polysaccharide with a pH of 4.6 and below for at least 10, 30, 60, 90, 120, 180 minutes. Examples of suitable anionic polysaccharides: pectin, alginates, carrageenans. Ideally, whey protein is teplogeneriruyuschim, although other methods of denaturation are also applicable, for example, denaturation induced pressure. In a preferred embodiment, the whey protein denatures at a temperature of from 75°C to 80°C, suitably for from 30 minutes to 50 minutes. Typically, whey protein mixed with thermal denaturation. Accordingly, the concentration of the whey protein is from 5 to 15%, preferably from 7 to 12%, and ideally from 9 to 11% (weight/volume). Typically, the implementation process is carried out by filtration through filters with a gradual reduction of pore size. Ideally, the fine filter and�States submicron pore size, for example, from 0.1 to 0.9 microns. The preferred method of producing microspheres is the way with the application encapsulators corresponding vibration (Inotech, Switzerland) and machines production of NISCO stock Engineering AG. Typically, the nozzles have openings 100 and 600 microns, and ideally about 150 microns.

The disadvantage of this method is the use of special equipment (encapsulators corresponding vibration (Inotech, Switzerland)), obtaining microcapsules by means of protein denaturation, the complexity of the allocation obtained by this method of microcapsules - filtration with the use of multiple filters, which makes the process lengthy.

In us Pat. WO/2011/003805 EP IPC B01J 13/18; B65D 83/14; C08G 18/00 described a method of producing microcapsules that are suitable for use in the compositions forming sealants, foams, coatings or adhesives.

The disadvantage of the proposed method is the use of centrifugation for separation from the process fluid, the duration of the process, and the application of this method in the pharmaceutical industry.

In us Pat. 20110223314, IPC B05D 7/00 20060101; B05D 007/00; B05C 3/02 20060101; B05C 003/02; B05C 11/00 20060101; B05C 011/00; B05D 1/18 20060101; B05D 001/18; B05D 3/02 20060101; B05D 003/02; B05D 3/06 20060101; B05D 003/06 from 10.03. 2011 US described a method of producing microcapsules by the method of suspension polymerization, belonging to the group of chemical methods with the use of a new device and UV exposure.

<> The disadvantages of this method are the complexity and duration of the process, the use of special equipment, the use of UV irradiation.

In us Pat. WO/2011/150138 US, IPC C11D 3/37; B01J 13/08; C11D 17/00, published on 01.12.2011, the method of obtaining microcapsules of a solid water-soluble agents polymerization.

The disadvantages of this method are the complexity and duration of the process.

In us Pat. WO/2011/127030 US, IPC A61K 8/11; B01J 2/00; B01J 13/06; C11D3/37; C11D 3/39; C11D 17/00, published on 13.10.2011 proposed several ways of obtaining microcapsules: interfacial polymerization, thermoinduced phase separation, spray drying, evaporation of the solvent, etc. the Disadvantages of the proposed methods is the difficulty, duration of processes, and the use of special equipment (filter (Albet, Dassel, Germany), spray dryer for collecting particles (Spray-4M8 Dryer from ProCepT, Belgium)).

The disadvantages of the proposed methods is the difficulty, duration of processes, and the use of special equipment (filter (Albet, Dassel, Germany), spray dryer for collecting particles (Spray-4M8 Dryer from ProCepT, Belgium)).

In us Pat. WO/2011/104526 GB, IPC B01J 13/00; B01J 13/14; C09B 67/00; C09D 11/02, published on 01.09.2011, a method of producing a dispersion of encapsulated solid particles in a liquid medium, comprising: a) grinding com�osili, including solid, liquid medium and a polyurethane dispersant with an acid number of from 0.55 to 3.5 mmol per gram of dispersant, said composition includes 5 to 40 parts of the polyurethane dispersant per 100 parts of solid product by weight; and b) crosslinking the polyurethane dispersant in the presence of solid and liquid medium so as to encapsulate the solid particles which the polyurethane dispersant contains less than 10% by weight of recurring items from polymer alcohols.

The disadvantages of the proposed method are the complexity and duration of the process of production of microcapsules, and that the encapsulated particles by the proposed method are useful as colorants in inks, especially ink jet printing, for the pharmaceutical industry this practice is not applicable.

B Pat. WO/2011/056935 US, IPC C11D 17/00; A61K 8/11; B01J 13/02; C11D 3/50, published on 12.05.2011, a method for producing microcapsules with a size of 15 microns. As the shell material of the proposed polymers of the group consisting of polyethylene, polyamides, polystyrene, polyisoprenes, polycarbonates, polyesters, polyacrylates, polyureas, polyurethanes, polyolefins, polysaccharides, epoxy resins, vinyl polymers and mixtures thereof. Proposed polymeric membranes are relatively impermeable to the core material and materials in the environment�e, in which are encapsulated agents, the benefit will be used to provide benefits that will be received. The core of the encapsulated agents may include perfume, silicone oils, waxes, hydrocarbons, higher fatty acids, essential oils, lipids, cooling the skin fluids, vitamins, sunscreens, antioxidants, glycerine, catalysts, bleach particles, particles of silicon dioxide, etc.

The disadvantages of the proposed method are the complexity, the duration of the process, using as the shells of the microcapsules of polymers of synthetic origin and their mixtures.

The closest method is the method proposed in us Pat. 2134967, IPC A01N 53/00, A01N 25/28, published 27.08.1999, Russian Federation (1999). In water dispersed solution of a mixture of natural lipids and PYRETHROID insecticide in a weight ratio of 2-4:1 in an organic solvent, which leads to simplification of the method of microencapsulation.

The disadvantage is the dispersion in an aqueous medium, which makes the proposed method applicable for obtaining microcapsules of water-soluble drugs in water-soluble polymers.

The technical objective is the simplification and acceleration of the process of obtaining microcapsules of antioxidants in pectin, reducing loss upon receipt of the microcapsules (increase of the yield by weight).

Decisions� technical problem is achieved by a method of producing microcapsules of antioxidants, characterized in that as the shell of the microcapsules used pectins, as well as obtaining microcapsules physico-chemical deposition method by nerastvorim using two precipitators - ethanol and benzene, the process is carried out without special equipment.

A distinctive feature of the proposed method is the use as the shell of the microcapsules of antioxidants, pectin, and receipt of the microcapsules physico-chemical deposition method by nerastvorim using two precipitators - ethanol and benzene.

The result of the proposed method are obtaining microcapsules of antioxidants (vitamins A, C, E and Q10in the pectin at 25°C for 15 minutes. The output of the microcapsules is more than 90%.

Example 1. Obtaining microcapsules of vitamin A in low-esterified Apple pectin, a ratio of 1:3

To 3 g of the slurry nizkoenergeticheskogo pectin in ethanol 0.01 g of the drug Is as surfactants. The resulting mixture is put on the magnetic stirrer and turn the stirring. 1 g of a suspension of vitamin A in dimethylsulfoxide is added to a slurry of pectin in ethanol. Then add 5 ml of benzene and 1 ml of water. The resulting suspension of microcapsules is filtered on the filter SCHOTT 16 class then, washed with toluene, dried in a desiccator over chloride� calcium.

Obtained 3.8 g of a white powder. The yield was 95%.

Example 2. Obtaining microcapsules of vitamin A in Apple vysokodetalizirovannom pectin, a ratio of 1:3

To 3 g of the slurry vysokotarifitsirovannyh pectin in ethanol 0.01 g of the drug Is as surfactants. The resulting mixture is put on the magnetic stirrer and turn the stirring. 1 g of a suspension of vitamin A in 1 ml DMSO and transferred into a slurry of pectin in ethanol. After that add 3 ml of benzene, and then 1 ml of distilled water. The resulting suspension of microcapsules is filtered on the filter SCHOTT 16 class then, washed with toluene, dried in a desiccator over calcium chloride.

Obtained 3.85 g of a white to cream color powder. The output was 96,25%.

Example 3. Obtaining microcapsules of vitamin A in low-esterified citrus pectin, a ratio of 1:3

To 3 g of the slurry nizkoenergeticheskogo pectin in ethanol 0.01 g of the drug Is as surfactants. The resulting mixture is put on the magnetic stirrer and turn the stirring. 1 g of a suspension of vitamin A in dimethylsulfoxide is added to a slurry of pectin in ethanol. Then add 5 ml of benzene and 1 ml of water. The resulting suspension of microcapsules is filtered on the filter SCHOTT 16 class then, washed with toluene, dried in a desiccator over calcium chloride

Obtained 3.8 g of a white powder. The yield was 95%.

Example 4. Obtaining microcapsules of vitamin A in citrus vysokodetalizirovannom pectin, a ratio of 1:3

To 3 g of the slurry vysokotarifitsirovannyh pectin in ethanol 0.01 g of the drug Is as surfactants. The resulting mixture is put on the magnetic stirrer and turn the stirring. 1 g of a suspension of powder of vitamin A in 1 ml DMSO and transferred into a slurry of pectin in ethanol. After that add 3 ml of benzene, and then 1 ml of distilled water. The resulting suspension of microcapsules is filtered on the filter SCHOTT 16 class then, washed with toluene, dried in a desiccator over calcium chloride.

Obtained 3.85 g of a white to cream color powder. The output was 96,25%.

Example 5. Obtaining microcapsules of vitamin C in Apple's low-esterified pectin, a ratio of 1:3

To 3 g of the slurry nizkoenergeticheskogo pectin in ethanol 0.01 g of the drug Is as surfactants. The resulting mixture is put on the magnetic stirrer and turn the stirring. 1 g of a suspension of vitamin C in dimethyl sulfoxide is added to a slurry of pectin in ethanol. Then add 5 ml of benzene and 1 ml of water. The resulting suspension of microcapsules is filtered on the filter SCHOTT 16 class then, washed with toluene, dried in a desiccator over chloride �Altium.

Received of 3.92 g of a white powder. The yield was 98%.

Example 6. Obtaining microcapsules of vitamin C in Apple vysokodetalizirovannom pectin, a ratio of 1:3

To 3 g of the slurry vysokotarifitsirovannyh pectin in ethanol 0.01 g of the drug Is as surfactants. The resulting mixture is put on the magnetic stirrer and turn the stirring. 1 g of a suspension of vitamin C in 1 ml DMSO and transferred into a slurry of pectin in ethanol. After that add 3 ml of benzene, and then 1 ml of distilled water. The resulting suspension of microcapsules is filtered on the filter SCHOTT 16 class then, washed with toluene, dried in a desiccator over calcium chloride.

Received 3,912 g of a white to cream color powder. The yield was 97.8%.

Example 7. Obtaining microcapsules of vitamin C in citrus fruits low-esterified pectin, a ratio of 1:3

To 3 g of the slurry nizkoenergeticheskogo pectin in ethanol 0.01 g of the drug Is as surfactants. The resulting mixture is put on the magnetic stirrer and turn the stirring. 1 g of a suspension of vitamin C in dimethyl sulfoxide is added to a slurry of pectin in ethanol. Then add 5 ml of benzene and 1 ml of water. The resulting suspension of microcapsules is filtered on the filter SCHOTT 16 class then, washed with toluene, dried in a desiccator over chloride of Calle�.

Received 3,88 g of a white powder. The yield was 97%.

Example 8. Obtaining microcapsules of vitamin C in citrus vysokodetalizirovannom pectin, a ratio of 1:3

To 3 g of the slurry vysokotarifitsirovannyh pectin in ethanol 0.01 g of the drug Is as surfactants. The resulting mixture is put on the magnetic stirrer and turn the stirring. 1 g of a suspension of the powder of vitamin C in 1 ml DMSO and transferred into a slurry of pectin in ethanol. After that add 3 ml of benzene, and then 1 ml of distilled water. The resulting suspension of microcapsules is filtered on the filter SCHOTT 16 class then, washed with toluene, dried in a desiccator over calcium chloride.

Obtained 3.85 g of a white to cream color powder. The output was 96,25%.

Example 9. Obtaining microcapsules of vitamin E in low-esterified Apple pectin, a ratio of 1:3

To 3 g of the slurry nizkoenergeticheskogo pectin in ethanol 0.01 g of the drug Is as surfactants. The resulting mixture is put on the magnetic stirrer and turn the stirring. 1 g of a suspension of vitamin E in dimethylsulfoxide is added to a slurry of pectin in ethanol. Then add 5 ml of benzene and 1 ml of water. The resulting suspension of microcapsules is filtered on the filter SCHOTT 16 class then, washed with toluene, dried in a desiccator over floristically.

Received 3,88 g of a white powder. The yield was 97%.

Example 10. Obtaining microcapsules of vitamin E in Apple vysokodetalizirovannom pectin, a ratio of 1:3

To 3 g of the slurry vysokotarifitsirovannyh pectin in ethanol 0.01 g of the drug Is as surfactants. The resulting mixture is put on the magnetic stirrer and turn the stirring. 1 g of a suspension of vitamin E in 1 ml DMSO and transferred into a slurry of pectin in ethanol. After that add 3 ml of benzene, and then 1 ml of distilled water. The resulting suspension of microcapsules is filtered on the filter SCHOTT 16 class then, washed with toluene, dried in a desiccator over calcium chloride.

Received 3.94 g of white to cream color powder. The yield was 98.5%.

Example 11. Obtaining microcapsules of vitamin E in low-esterified citrus pectin, a ratio of 1:3

To 3 g of the slurry nizkoenergeticheskogo pectin in ethanol 0.01 g of the drug Is as surfactants. The resulting mixture is put on the magnetic stirrer and turn the stirring. 1 g of a suspension of vitamin E in dimethyl sulfoxide is added to a slurry of pectin in ethanol. Then add 5 ml of benzene and 1 ml of water. The resulting suspension of microcapsules is filtered on the filter SCHOTT 16 class then, washed with toluene, dried in a desiccator over chloride of Calle�.

Obtained with 3.96 g of a white powder. The yield was 99%.

Example 12. Obtaining microcapsules of vitamin E in citrus vysokodetalizirovannom pectin, a ratio of 1:3

To 3 g of the slurry vysokotarifitsirovannyh pectin in ethanol 0.01 g of the drug Is as surfactants. The resulting mixture is put on the magnetic stirrer and turn the stirring. 1 g of a suspension of the powder of vitamin E in 1 ml DMSO and transferred into a slurry of pectin in ethanol. After that add 3 ml of benzene, and then 1 ml of distilled water. The resulting suspension of microcapsules is filtered on the filter SCHOTT 16 class then, washed with toluene, dried in a desiccator over calcium chloride.

Obtained 3.9 g of white to cream color powder. The output was 97,55%.

Example 13. Obtaining microcapsules of vitamin Q10in Apple's low-esterified pectin, a ratio of 1:3

To 3 g of the slurry nizkoenergeticheskogo pectin in ethanol 0.01 g of the drug Is as surfactants. The resulting mixture is put on the magnetic stirrer and turn the stirring. 1 g of a suspension of vitamin Q10in dimethylsulfoxide is added to a slurry of pectin in ethanol. Then add 5 ml of benzene and 1 ml of water. The resulting suspension of microcapsules is filtered on the filter SCHOTT 16 class then, washed with toluene, dried in execute�e over calcium chloride.

Obtained 3.8 g of a white powder. The yield was 95%.

Example 14. Obtaining microcapsules of vitamin Q10in Apple vysokodetalizirovannom pectin, a ratio of 1:3

To 3 g of the slurry vysokotarifitsirovannyh pectin in ethanol 0.01 g of the drug Is as surfactants. The resulting mixture is put on the magnetic stirrer and turn the stirring. 1 g of a suspension of vitamin Q10in 1 ml DMSO and transferred into a slurry of pectin in ethanol. After that add 3 ml of benzene, and then 1 ml of distilled water. The resulting suspension of microcapsules is filtered on the filter SCHOTT 16 class then, washed with toluene, dried in a desiccator over calcium chloride.

Obtained with 3.96 g of a white to cream color powder. The yield was 99%.

Example 15. Obtaining microcapsules of vitamin Q10in low-esterified citrus pectin, a ratio of 1:3

To 3 g of the slurry nizkoenergeticheskogo pectin in ethanol 0.01 g of the drug Is as surfactants. The resulting mixture is put on the magnetic stirrer and turn the stirring. 1 g of a suspension of vitamin Q10in dimethylsulfoxide is added to a slurry of pectin in ethanol. Then add 5 ml of benzene and 1 ml of water. The resulting suspension of microcapsules is filtered on the filter SCHOTT 16 class then, washed with toluene, dried in ek�icecore over calcium chloride.

Obtained with 3.96 g of a white powder. The yield was 99%.

Example 16. Obtaining microcapsules of vitamin Q10in citrus vysokodetalizirovannom pectin, a ratio of 1:3

To 3 g of the slurry vysokotarifitsirovannyh pectin in ethanol 0.01 g of the drug E472 with as surfactants. The resulting mixture is put on the magnetic stirrer and turn the stirring. 1 g of a suspension of powder of vitamin Q10in 1 ml DMSO and transferred into a slurry of pectin in ethanol. After that add 3 ml of benzene, and then 1 ml of distilled water. The resulting suspension of microcapsules is filtered on the filter SCHOTT 16 class then, washed with toluene, dried in a desiccator over calcium chloride.

Obtained 3.85 g of a white to cream color powder. The output was 96,25%.

The obtained microcapsules of antioxidants in Apple and citrus pectin physico-chemical deposition method by nerastvorim using toluene and ethanol as nerastvorimaya. The process is simple to perform and lasts for 15 minutes, requires no special equipment.

Pectin (E440) is widely used in manufacture of jelly confectionery and pastel products for stabilization of fermented milk products, in the production of jam, as well as in bakery and pastry products. There are data on the use of pecti�s as stabilizers of constituency creams, lotions, shampoos.

Es - ester of glycerol with one or two molecules of dietary fatty acids and one or two molecules of citric acid, and citric acid as tribasic can be etherification other glycerides and as oxanilate - other fatty acids. Free acid groups can be neutralized with sodium.

A method of producing microcapsules of vitamins A, C, E, or Q10, characterized by the fact that 3 g of the slurry vysokotarifitsirovannyh or Apple or low-esterified citrus pectin in ethanol was added 0.01 g of the drug Is as a surfactant, the resulting mixture was stirred, and then 1 g of a suspension of vitamin in dimethyl sulfoxide was added to a slurry of pectin in ethanol, flow 3 ml or 5 ml of benzene and 1 ml of distilled water, the resulting suspension was filtered, washed with toluene and dried.



 

Same patents:

FIELD: chemistry.

SUBSTANCE: invention relates to field of encapsulation, in particular to method of obtaining microcapsules of medications from cephalosporin group in human leukocyte interferon (β- or α-interferon) coat. In accordance to invention cephalosporin powder and E472c preparation are added to 1% water solution of human leukocyte interferon in α- or β-form and mixed until reaction mixture components dissolve. After formation of transparent solution butanol and acetone are added. Obtained suspension of microcapsules is filtered, washed and dried. Process of obtaining microcapsules is realised at 25°C for 15 min.

EFFECT: invention provides simplification and acceleration of process of obtaining microcapsules, reduction of loss in the process of their obtaining (increase of output by weight).

4 ex

FIELD: chemistry.

SUBSTANCE: invention relates to field of nanocapsulation in obtaining nanocapsules of glucoamine sulphate in xanthan gum envelope. In accordance with invention glucosamine sulphate is added by portions into suspension of xanthan gum in butyl alcohol, containing preparation E472c as surfactant. Mixture is mixed, after that hexane is added, obtained mixture of nanocapsules is filtered, washed with hexane and dried. Process is realised at 25°C for 15 minutes.

EFFECT: method in accordance with invention provides simplification and acceleration of process of obtaining glucosamine sulphate nanocapsules in xanthan gum and increase of output by weight.

2 ex

FIELD: chemistry.

SUBSTANCE: potassium losartan is added by portions into a suspension of xanthane gum in benzene in the presence of the preparation E472 with mixing at 1000 rev/sec. Then hexane is added. The obtained suspension of nanocapsules is filtered and dried at room temperature. The envelope:core ratio constitutes 3:1 or 1:5.

EFFECT: simplification and acceleration of the process of obtaining nanocapsules and an increase of output by weight.

2 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to the field of medicine and describes a method of obtaining ferrocene microcapsules, where xanthan gum is used as an envelope for the microcapsules, characterised by the fact that a suspension of 100 mg of ferrocene in 2 ml of benzene is dispersed into a suspension of xanthan gum in the presence of 0.01 g of E472 c preparation with mixing, with the addition of 5 ml of acetone and 0.5 ml of water; the obtained suspension is filtered and dried at room temperature.

EFFECT: invention provides the simplification and acceleration of the process of obtaining the microcapsules and increase of output by weight.

1 dwg, 2 ex

FIELD: chemistry.

SUBSTANCE: invention relates to a method of encapsulating alkaloids. Said method is characterised by that an alkaloid is dissolved in dioxane, dimethyl sulphoxide or dimethyl formamide, then dispersed in a mixture of sodium carboxymethyl cellulose and acetone in the presence of E472c, adding distilled water, filtering and drying the obtained suspension of microcapsules, wherein the core/polymer ratio in the microcapsules is 1:3.

EFFECT: invention provides a simple and fast process of producing alkaloid microcapsules and increases mass output.

19 ex

FIELD: metallurgy.

SUBSTANCE: under the suggested method of the melts granulation including product melt supply to the liquid inert medium in form of jets flowing from the calibrated holes, with installed needles, the inert medium is melt. Melting temperature of the inert medium is below melting temperature of the granulated material. The obtained product granules are cooled in the inert liquid to temperature (20-30)°C. The inert liquid density is higher than the inert medium density and below the product granules density. The product melting temperature is (1.5-1.25) of melting temperature of the granulated material, and inert medium temperature is (1.05-1.15) of its melting temperature.

EFFECT: increased quality of produced granulated product, and capacity of the process of melt granulation due to contact of the product melt droplets with inert medium in form of the melt heated to temperature below the melting temperature of the granulated material.

3 tbl

FIELD: chemistry.

SUBSTANCE: in the disclosed microencapsulation method, which includes feeding a coating melt into a fluidised layer of heated granular material, the melt is fed to particles of the granular material through porous heated surfaces located above the fixed layer of granular material and which vibrate in the vertical plane. Temperature of the porous heated surface is 1.05 to 1.25 times the melting point of the coating substance.

EFFECT: high efficiency of the process of microencapsulation of granular materials and the quality of the obtained product owing to contact between the particles of the granular material and the porous heated surfaces, through which the coating melt enters the apparatus and into the fluidised layer of granular material.

FIELD: chemistry.

SUBSTANCE: invention relates to a method of producing metribuzin microcapsules. Said method is characterised by that polyvinyl alcohol solution is mixed with metribuzin and an E472c preparation as an emulsifier; the obtained mixture is stirred until components of the reaction mixture dissolve and after formation of a transparent solution, ethyl acetate is slowly added in droplets as a first precipitant and then isopropanol as a second precipitant; the obtained microcapsule suspension is settled for 1 minute and then filtered, washed with isopropanol and dried.

EFFECT: invention provides a simple process of producing microcapsules with a water-soluble envelope and increases mass output.

3 ex

FIELD: chemistry.

SUBSTANCE: method is implemented by supplying an additional heat-transfer fluid into the upper part of a fluidised bed of a loose material; gas temperature makes from 0.7 to 0.8 of a coating melting temperature. In the presented method for loose material microencapsulation involving supplying a fusible coating melt into the fluidised bed of the heated loose material; the heat-transfer fluid is supplied through perforated surfaces above a fixed layer of the loose material.

EFFECT: higher quality of the produced material and processing rate of loose material microencapsulation.

2 tbl

FIELD: chemistry.

SUBSTANCE: invention relates to encapsulation. A method of producing lithium chloride microcapsules in a sodium alginate envelope comprises: adding a suspension of lithium chloride in benzene to a suspension of sodium alginate in butanol in the presence of an E472c preparation while stirring at 1200 rps; the lithium chloride and said polymer are taken in weight ratio of 1:1 or 1:3; adding chloroform; and filtering and drying the obtained suspension of microcapsules. The process of producing the microcapsules is carried out at room temperature for 10 minutes.

EFFECT: method provides a simple and fast process of producing microcapsules and increases mass output.

3 dwg, 3 ex

FIELD: chemistry.

SUBSTANCE: invention relates to field of encapsulation, in particular to method of obtaining microcapsules of medications from cephalosporin group in human leukocyte interferon (β- or α-interferon) coat. In accordance to invention cephalosporin powder and E472c preparation are added to 1% water solution of human leukocyte interferon in α- or β-form and mixed until reaction mixture components dissolve. After formation of transparent solution butanol and acetone are added. Obtained suspension of microcapsules is filtered, washed and dried. Process of obtaining microcapsules is realised at 25°C for 15 min.

EFFECT: invention provides simplification and acceleration of process of obtaining microcapsules, reduction of loss in the process of their obtaining (increase of output by weight).

4 ex

FIELD: chemistry.

SUBSTANCE: potassium losartan is added by portions into a suspension of xanthane gum in benzene in the presence of the preparation E472 with mixing at 1000 rev/sec. Then hexane is added. The obtained suspension of nanocapsules is filtered and dried at room temperature. The envelope:core ratio constitutes 3:1 or 1:5.

EFFECT: simplification and acceleration of the process of obtaining nanocapsules and an increase of output by weight.

2 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to the field of medicine and describes a method of obtaining ferrocene microcapsules, where xanthan gum is used as an envelope for the microcapsules, characterised by the fact that a suspension of 100 mg of ferrocene in 2 ml of benzene is dispersed into a suspension of xanthan gum in the presence of 0.01 g of E472 c preparation with mixing, with the addition of 5 ml of acetone and 0.5 ml of water; the obtained suspension is filtered and dried at room temperature.

EFFECT: invention provides the simplification and acceleration of the process of obtaining the microcapsules and increase of output by weight.

1 dwg, 2 ex

FIELD: chemistry.

SUBSTANCE: invention relates to a method of encapsulating alkaloids. Said method is characterised by that an alkaloid is dissolved in dioxane, dimethyl sulphoxide or dimethyl formamide, then dispersed in a mixture of sodium carboxymethyl cellulose and acetone in the presence of E472c, adding distilled water, filtering and drying the obtained suspension of microcapsules, wherein the core/polymer ratio in the microcapsules is 1:3.

EFFECT: invention provides a simple and fast process of producing alkaloid microcapsules and increases mass output.

19 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to the field of microencapsulation, in particular to a method of obtaining microcapsules of medications of a cephalosporin group. The method is characterised by the fact that human serum albumin is used as an envelope for microcapsules, with the addition to a water solution of albumin of a powder of a cephalosporin group preparation in the presence of a surface-active substance E472c, the ratio of quantity of the cephalosporin group preparation to albumin counted per dry substance constitutes from 1:1 to 3:1, the obtained mixture is mixed to the complete dissolution of components with the slow drop-by-drop addition of butanol as the first precipitating agent, and then acetone as the second precipitating agent, the obtained suspension of microcapsules is filtered, washed with acetone, dried in a dessicator, the process of obtaining microcapsules is realised at 25°C.

EFFECT: method provides the simplification and acceleration of the process of obtaining microcapsules of the water-soluble medications of a cephalosporin group in human serum albumin, and reduction of loss in obtaining the microcapsules.

3 ex

FIELD: medicine.

SUBSTANCE: method of obtaining encapsulated native blood, which is characterised by the fact that suspension of native blood in diethyl ether is dispersed in mixture of sodium carboxymethylcellulose in benzene, in presence E472, mixed, with pouring hexane and water to obtained mixture, obtained suspension is filtered and dried under specified conditions.

EFFECT: method makes it possible to simplify and accelerate process of obtaining encapsulated native blood.

2 dwg, 2 ex

FIELD: chemistry.

SUBSTANCE: invention relates to a method of producing metribuzin microcapsules. Said method is characterised by that polyvinyl alcohol solution is mixed with metribuzin and an E472c preparation as an emulsifier; the obtained mixture is stirred until components of the reaction mixture dissolve and after formation of a transparent solution, ethyl acetate is slowly added in droplets as a first precipitant and then isopropanol as a second precipitant; the obtained microcapsule suspension is settled for 1 minute and then filtered, washed with isopropanol and dried.

EFFECT: invention provides a simple process of producing microcapsules with a water-soluble envelope and increases mass output.

3 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to pharmaceutical industry, namely to method of obtaining encapsulated native blood. Method of obtaining encapsulated native blood is characterised by the fact that suspension of native blood in diethyl ether is dispersed into mixture of sodium carboxymethylcellulose in benzene in presence of E472, mixed, with the following pouring of hexane and water to obtained mixture and further filtration and drying of obtained suspension under specified conditions.

EFFECT: method makes it possible to simplify and accelerate process of obtaining encapsulated native blood.

4 dwg, 2 ex

FIELD: chemistry.

SUBSTANCE: invention provides a method of encapsulating a medicinal preparation via non-solvent addition, characterised by that the core of the microcapsules used is fenbendazole, the envelope used is sodium carboxymethyl cellulose which is deposited from a solution in toluene by adding, as the nonsolvent, carbinol and water at 25°C.

EFFECT: simpler and faster process of producing microcapsules and reduced losses when producing microcapsules.

3 ex

FIELD: chemistry.

SUBSTANCE: invention provides a method of encapsulating a medicinal preparation via non-solvent addition, characterised by that the core of the microcapsules used is fenbendazole, the envelope used is sodium carboxymethyl cellulose which is deposited from a solution in cyclohexanol by adding, as the nonsolvent, isopropanol and water at 25°C.

EFFECT: simpler and faster process of producing microcapsules and reduced losses when producing microcapsules.

3 ex

FIELD: chemistry.

SUBSTANCE: invention relates to field of nanocapsulation in obtaining nanocapsules of glucoamine sulphate in xanthan gum envelope. In accordance with invention glucosamine sulphate is added by portions into suspension of xanthan gum in butyl alcohol, containing preparation E472c as surfactant. Mixture is mixed, after that hexane is added, obtained mixture of nanocapsules is filtered, washed with hexane and dried. Process is realised at 25°C for 15 minutes.

EFFECT: method in accordance with invention provides simplification and acceleration of process of obtaining glucosamine sulphate nanocapsules in xanthan gum and increase of output by weight.

2 ex

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