Polymer composition for medical surgical instruments

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to medicine, namely to a polymer composition for medical devices containing polycarbonate with a degree of polymerisation of n=200-2,000 in an amount of 100 weight fractions, a polymer additive, which is presented by polysulphon at a degree of polymerisation of n=70-150, in an amount of 5 to 40 weight fractions, a complex stabiliser, which is presented by sterically hindered phosphite in an amount of 0.045 to 1.5 weight fractions, a compatibiliser representing maleinised polypropylene in an amount of 0.025 to 5.0 weight fractions, a nanostructured additive representing carbon nanotube superconcentrate with the nanotube content of 20-40 weight fractions in butadiene oligomer with a degree of polymerisation of 6 in an amount of 0.01 to 1.0 weight fractions.

EFFECT: invention provides creating the polymer composition with high strength characteristics.

3 cl, 1 ex, 2 tbl

 

The invention relates to the field of medicine and to polymeric materials and more particularly to polymer compositions for surgical instruments.

Medical surgical instruments are made of martensitic chromium steels. However, the active spread of diseases such as hepatitis b and C, HIV, and other, leads to tighter modes of sterilization and introduction of new and more effective means for this purpose.

Particularly relevant is the use of technology for medical practice tools disposable, which should ensure high functional properties and biological compatibility with body tissues.

Known medical material treated with ionizing radiation with a radiation dose of from 5 to 100 kGy and containing a biodegradable resin and polycarbamide compound in an amount of from 0.1 to 10% by weight of the resin. This biodegradable resin includes at least one resin selected from the group consisting of polybutylmethacrylate and copolymer of polybutylmethacrylate, and polylactic acid or poly(3-hydroxyalkanoate) in an amount of from 0 to 50% by weight of the specified polybutylmethacrylate resin, taken as the analog of the [patent RU No. 24466744, C2, publ. 20.11.2012].

Of the compositions according to the analog gain of the device or instrument for use in surgery, therapy Il� diagnosis, carried out in humans or animals, however, the strength characteristics of these compositions are not high enough.

Known luminescent composite material comprising as polymer matrix thermoplastic polymer is polycarbonate or polystyrene or copolymer of styrene with Acrylonitrile and butadiene, photoluminous on the basis of garnet Y3Al5O12:Ce or Gd3Al5O12:Ce or a mixture of these compounds, a polyethylene wax in the form of a powder with a particle size of 18-30 microns and a stabilizer based on compounds from the group of sterically obstructed phosphites, which is taken as a prototype [patent RU No. 2405804, C1, publ. 10.12.2010].

The compositions of the prior art receive the device for General and local lighting, and this composition was not used for medical instruments.

The technical result is the creation of polymeric compositions for medical devices with enhanced strength characteristics.

This technical result is achieved by a polymer composition for medical instruments, comprising the following components, wt.h.: polycarbonate - 100, polymer additive 5÷40, integrated stabilizer 0,2÷1,5, nanostructurered additive in the oligomer of butadiene 0,01÷1,0 and compatibilization 0,025÷5,0. As polymer additives used polysulfone. As St�of beliator composition comprises a compound from the group of sterically obstructed phosphites in an amount of from 0,045 to 1.5 wt.h. As nanomodified additive composition comprises a superconcentrate of carbon nanotubes in the oligomer of the polybutylene terephthalate in an amount of from 0.01 to 1.0 wt.h. As compatibilizer composition comprises maleated polypropylene. The invention provides a medical composition to provide the required level of properties.

As the polycarbonate composition may include the polycarbonate, for example with a degree of polymerization n = 200÷2000,

preferably with a melt flow rate of (AV) 3-30 g/10 min.

As polymer additives, the composition may contain suitable polysulfone, for example with a degree of polymerization n = 70÷50,

preferably with a melt flow rate of 4 to 7 g/10 min.

As nanomodified additives, the composition may contain superconcentrate carbon nanotubes (nanotubes 20-40 wt.h.) in the butadiene oligomer (degree of polymerization n = 6).

As an integrated stabilizer composition may contain compounds based on sterically obstructed phosphites bis(2,4-di-tert-butyl)a pentaerythritol diphosphite or bis(2,4-dokumenter)pentaerithritol the diphosphite S9226, or three(2,4-di-tertbutylphenyl)postit or a mixture thereof.

As compatibilizer, the composition may contain maleated polypropylene.

Composition goth�present by mixing pellets of the polymer in the first polymer additives, second nanostructurered addition, in the third - stabilizer, the fourth - compatibilization, thorough mixing of the starting components, carried out in the mixer rotor type.

The manufacture of the composite material provides a highly efficient method of polymer processing - injection molding with the use of back pressure to ensure uniform distribution of the components in the melt of the polymer matrix on the injection molding machine, for example ALLROUNDER C 700-250 firm "Arburg Maschinenfabrik Hehl & Sohne" that contributes to the processing of the material in various desired configurations.

Example 1. Polycarbonate, brand Carbomix 20 FC (manufacturer LLC "Gamma-Plast"), q=21, degree of polymerization n=1000, in the amount of 100 parts by weight.h. mixed with 10 wt.h. polysulfone, PSF brand-150 (production of JSC "Institute of Plastics"), AV=4, degree of polymerization n=125, then to this mixture was added to 0.33 wt.h. stabilizer on the basis of Ultranox 626 (bis(2,4-di-tert-butyl)a pentaerythritol diphosphite), 0.1 wt.h. nanostrukturelle additives, Arkema brand, the content of carbon nanotubes 30 wt.h. in the butadiene oligomer with degree of polymerization n=6, the length of carbon nanotubes ≈ 1 μm, the diameter of 10-100 nm, and 0.7 wt.h. compatibilizer PP-MAN (maleated polypropylene), and all the components are mixed in the mixer for 10±5 minutes,�Le what is composition style in the material on the injection moulding machine ALLROUNDER C 700-250.

The compositions according to the examples in accordance with the invention (table 1) is produced analogously to example 1.

The composition and properties of polymeric materials are shown in tables 1 and 2.

Turnover rates of the melts of polymers are measured according to GOST 11645-73.

The results, shown in table 2, it is seen that the polymer composition have high physical-mechanical characteristics.

Table 1
The composition
The components of the compositionThe composition
123456789101112
Polycarbonate100100100100100100100100 100100100100
Polysulfone10102553020252040301035
Nanostructurered Supplement0,010,660,050,0250,550,251,00,351,00,95od0,45
Integrated stabilizer0,050,0450,20,050,71,50,81,21,50,60,331,4
Compatibilization 0,0250,50,050,51,01,02,51,255,03,30,74,1

Table 2
Properties of the obtained composite materials:
Song number
123456789101112
MFR, g/10 min20231719231926241618 2218
Tensile strength, MPa626365616870596667657172
Elongation at break, %343326353328353226211531
Flexural strength before UV irradiation (UV after investment), MPa82 (92)84 (89)84 (88)90 (93)94 (94)98(100)83 (86)89 (90)91 (100)88 (90)95 (95)100(102)
Udorn�I viscosity, kJ/m2not destroyednot destroyednot destroyednot destroyednot destroyednot destroyednot destroyednot destroyedNot destroyednot destroyednot destroyednot destroyed
Wear, g·10-4412627402424352330332822
Technological shrinkage, %0,350,30,40,30,250,350,20,250,40,20,30,35
In�pogloshenie, %0,10,050,150,050,050,10,40,30,450,250,150,3

1. Polymer composition for medical products, including polycarbonate with degree of polymerization n=200-2000 in the amount of 100 parts by weight.h., polymer additive, which is used as the polysulfone with degree of polymerization n=70-150, in an amount of from 5 to 40 wt.h., complex stabilizer, which is used as the sterically hindered pofit, in an amount of from 0,045 to 1.5 wt.h., compatibilization representing maleated polypropylene, in an amount of from 0.025 to 5.0 wt.h., nanostructures additive, representing a superconcentrate of carbon nanotubes with the content of nanotubes 20-40 wt.h. in the butadiene oligomer with degree of polymerization of 6, in an amount of from 0.01 to 1.0 wt.h.

2. Polymer composition for medical devices according to claim 1, characterized in that the sterically hindered postit is selected from bis(2,4-di-tert-butyl)pentaerythritol diphosphite or bis(2,4-dokumenter)pentaerithritol diphosphite, or three(2,4-di-tertbutylphenyl)phosphite, or �MESI.

3. Polymer composition for medical devices according to claim 1, characterized in that nanostructurered additive is a superconcentrate of carbon nanotubes with the content of nanotubes 20-40 wt.h. in the butadiene oligomer with degree of polymerization of 6, in the form of granules with the following sizes of nanotubes - length of ≈ 1 μm, the diameter of 10-100 nm.



 

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