Method of treating drug sialoadenopathy

FIELD: medicine.

SUBSTANCE: vitamins A and E, novocaine blocades of parotid salivary glands, intake of potassium iodide solution, intake of galantamine, additionally administered is "Vezugen" in a dose of 2 tablets (capsules) 2 times per day for 30 days are administered.

EFFECT: invention makes it possible to stimulate the formation of own saliva in patients in case of drug sialoadenopathy, conditioned by chemotherapy of malignant tumours.

2 ex

 

The invention relates to medicine, namely to surgical dentistry and maxillofacial surgery, and can be used in the treatment of drug sialadenitis caused by chemotherapy of malignant tumors of any localization.

Known physiotherapeutic method of treatment of diseases of the salivary glands, namely, ultrasonic therapy is the area of the temporomandibular joint. The method is carried out in a pulsed mode (pulse duration 1-10ms), the technique of the movable contact of the vibrator straight. The intensity of 0.05-0.2 W/cm2, duration 3-5 minutes, every other day ("Physiotherapy Handbook" ed. by I. N. Sosina, Kiev, 1973).

A method of treating diseases of the salivary glands by acoustic stimulation, characterized in that conduct a prolonged influence on the neuro-muscular tissues of the maxillofacial region with an audible oscillation frequency 2.4 to 3.3 kHz, the sound pressure of not less than 1 PA at a length of 0.15 to 12 hours (Patent RF №2110247).

A method of treating diseases of the parotid salivary glands at points VB2 (ting-Hui), E6 (Chia-che), E7 (Xia-Guan), and for diseases of the submandibular salivary glands at the point E5 (Yes-in) produce production 1 leech at a point in time prior to the full cavansite the course of treatment 9 to 11 treatments for men and 8 to 10 for W�NSIN with an interval of two-three days alternately on the right and left salivary glands (Patent RF №249947).

The known method of treatment that is carried in the salivary glands of rats applied drug that contains diclofenac-sodium - 1 wt.% and glycerogel silicon as helium basics - the rest. The application of the drug is administered daily single dose of 50 mg/kg on an area of not more than 4 cm2. The course of treatment - no more than 14 days. The invention allows to quickly arrest the inflammation by using only local drug action due to its high transcutaneous conductivity and anti-inflammatory activity (Method of treatment of inflammatory diseases of the salivary glands - RF patent №2323723).

For the treatment of drug sialoadenitis arising after chemotherapy of malignant tumors of different localization, is restorative therapy and treatment, aimed at increasing the secretory function of the salivary glands (I. F. Romacheva, L. A. Yudin, V. V. Afanas'ev, A. N. Morozov. Diseases and injuries of the salivary glands. - M.: Medicine, 1987. - P. 69), as well as substitution therapy with use of artificial saliva or irrigation of the oral cavity infusions of herbs: chamomile, sage (Matina V. N. Diseases and tumors of the salivary glands. In: "Diseases, injuries and tumors of the maxillofacial localization, a Handbook of clinical dentistry edited by Professor A. K. Iordanishvili. - SPb.: With�Eclat, 2007. - S. 230). These funds are used in medical practice to ensure irritating to the epithelium of the salivary glands with the purpose of increasing its excretory activity to develop their own saliva or for the purpose of replacement of liquids saliva that does not increase the quality of life of patients.

All these methods have their positive and negative sides. The first method does not always improve the production of natural saliva and optimizes the production of saliva, causing dryness of the mouth, which is painful for the patient. The second method is ineffective.

The closest in technical essence is a method aimed at improving the function of the salivary glands to develop natural saliva due to the irritating action on the secretory epithelium of the salivary glands and providing, on the background of strengthening therapy with vitamins A and E, treatment aimed at enhancing the secretory function of the salivary glands, which use novocaine blockade of the parotid salivary glands 2 times a week during the month, a 2% solution of potassium iodide orally 1 table spoon 3 times a day, galantamine inside a 0.5% solution of 1 ml on an empty stomach daily for 30 days (I. F. Romacheva, L. A. Yudin, V. V. Afanas'ev, A. N. Morozov. Diseases and injuries of the salivary glands. - M.: Medicine, 1987. - P. 69). Complex data prep�the ATA allows you to stimulate your own saliva reducing the patients of the phenomenon of dryness in the mouth.

The disadvantages of this method are a slight increase in the secretory function of the salivary glands.

The purpose of the invention - improving the efficiency of treatment of drug sialoadenitis of the salivary glands caused by chemotherapy of malignant tumors of any localization, aimed at improving their excretory functions.

This object is achieved in that in the treatment of patients of drug sialoadenitis of the salivary glands caused by chemotherapy of malignant tumors, apply restorative therapy with vitamins a and E, and use novocaine blockade of the parotid salivary glands, shall receive a 2% solution of potassium iodide, galantamine and additionally with the start of treatment of the disease is prescribed "Vasogen" 2 capsules (tablets) 2 times a day with meals for 30 days.

"Vasogen" - dietary Supplement, developed on the basis of peptide complex that contains amino acids. Previously this tool was not used as irritating the secretory epithelium of the salivary glands and used for another purpose, namely to normalize the functional state of blood vessels in the complex treatment of patients suffering from atherosclerosis vessels of the heart, brain and lower limbs, impaired microcirculation different org�new and tissues in the psycho-emotional stress, as well as for the prevention of vascular diseases in elderly and senile age.

Biological active food Supplement "Vasogen" created LLC "Chemical-biological Association at Russian Academy of Sciences "Firm Vita" in the form of capsules or tablets based on amino acids (certificate of state registration № RU 77.99.11.003, E.0511 dated 04.05.2011).

In our technical solution is proposed to use the tablets (capsules) "Vespene" as a General means of sensitizing the secretory epithelium of the salivary glands and stimulating the formation of his own saliva in drug sialadenitis caused by chemotherapy of malignant tumors of any localization.

The method has been tested in a clinical setting in the treatment of drug sialadenitis caused by chemotherapy of malignant tumors.

Positive therapeutic effect was observed in all cases. He was to increase education amount of saliva in patients with drug sialadenitis caused by chemotherapy of malignant tumors.

Here are clinical observations.

Example 1. E. the patient, 60 years old, came with complaints of dryness in the mouth, the Ambassador of chemo therapy of malignant tumors of the middle part of the neck on the right. Last� completion of chemotherapy it took 19 days. The amount allocated to its own saliva in 20 minutes was 1.6 ml.

Diagnosed drug sialadenitis caused by chemotherapy of malignant tumors of the neck.

Appointed: vitamins A and E, procaine blockade of the parotid salivary glands 2 times a week during the month, a 2% solution of potassium iodide orally 1 table spoon 3 times a day, galantamine inside in the form of a 0.5% solution of 1 ml on an empty stomach daily for 30 days.

After 30 days notes some improvement, the amount allocated to its own saliva in 20 minutes 2,34 ml.

Example 2. Patient G., 65 years old, came with complaints of dryness in the mouth after chemotherapy of malignant tumor of the right breast. After chemotherapy it has been 25 days. The amount allocated to its own saliva in 20 minutes was 1.3 ml.

Diagnosed drug sialadenitis caused by chemotherapy of malignant tumor of the right breast.

Appointed: vitamins A and E, procaine blockade of the parotid salivary glands 2 times a week during the month, a 2% solution of potassium iodide orally 1 table spoon 3 times a day, galantamine inside in the form of a 0.5% solution of 1 ml on an empty stomach daily for 30 days and 2 capsules (tablets) 2 times a day with meals for 30 days biologically active food supplements "Vasogen".

After 30 days notes W�acetelyne improvement, the amount allocated to its own saliva within 20 minutes of 4.3 ml.

A method for the treatment of drug sialadenitis caused by chemotherapy of malignant tumors of different localization, with vitamins A and E, novocaine blockades of the parotid gland, 2% solution of potassium iodide inside, galantamine inside in the form of a 0.5% solution of 1 ml on an empty stomach daily for 30 days and the admission of the drug "Wespen", allows during the month to provide a significant improvement in the education of their own saliva in patients undergoing radiation therapy in the face.

A method for the treatment of drug sialadenitis caused by chemotherapy of malignant tumors of any localization, by taking in vitamins A and E, the use of novocaine blockades of the parotid salivary glands, solution of potassium iodide inside solution inside of galantamine, characterized in that additionally use the drug "Vasogen" 2 tablets (capsules) 2 times a day for 30 days.



 

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