Substrates containing switchable ferromagnetic nanoparticles

FIELD: chemistry.

SUBSTANCE: group of inventions relates to a process of producing organic substrate particles bonded to switchable ferromagnetic nanoparticles with a mean particle diameter ranging from 10 to 1000 nm, to the use of such nanoparticles for hyperthermic treatment of an organism and to a drug for the hyperthermc treatment. As the ferromagnetic nanoparticles used are nanoparticles, which are non-ferromagnetic at first, but become ferromagnetic when the temperature is lowered, these initially non-ferromagnetic dispersed nanoparticles are bonded to the organic substrate particles, and then the nanoparticles bonded to the substrate particles become ferromagnetic as a result of the temperature decrease, initially the switchable ferromagnetic nanoparticles at the temperature of 22°C or higher are not ferromagnetic and become ferromagnetic as a result of cooling down to the temperatures below 22°C. The switchable ferromagnetic nanoparticle comprises Mn and additionally Fe and/or As and preferably have the Fe2P-structure or Na-Zn-13-structure, alternatively, or may comprise La, Fe and Si.

EFFECT: invention prevents the agglomeration of particles and an increase in the mean particle size.

10 cl, 1 dwg, 2 ex

 

The invention relates to a method of producing organic particles of the substrate related to switchable ferromagnetic nanoparticles, relevant diagnostic substrate particles, and application of nanoparticles for hyperthermia treatment.

In the framework of the invention, the term "ferromagnetic" is understood as "ferromagnetic" and "magnetic".

Magnetic particles today versatile used for marking and manipulation of biological objects. Associated with antibody-magnetic particles are used, for example, for magnetic diagnostics of diseases. Difficulty in obtaining such small particles in the range of nanometers is the tendency of the magnetic particles to the formation of clods and aggregates. This complicates uniform adherence of antibodies to magnetic particles, and the particle size is undesirable increases greatly.

Magnetic particles, such as colloids, are used, for example, for hyperthermia treatment, especially in cancer therapy. Hyperthermia is a type of cancer treatment in which body tissue is exposed to high temperatures up to 45°C. it Was found that high temperatures can damage and kill cancer cells, usually with few side effects on normal tissue. By killing cancer cells and the destruction cleocin�nd patterns hyperthermia can be used to reduce tumors. Thus it is desirable to apply a more suitable magnetic particles that can be heated in the human body also by means of radio waves.

Further, it is known the binding of substances with magnetocaloric properties such as MnFePFor 0.35AsOf 0.65and MnAs, polymeric carriers for pharmacological agents. Application WO 2008/044963 describes this kind of associated particles of the medium, in which the heated magnetocaloric materials can change the properties of the release related polymer matrix for pharmacological active substance so that the active substance can be released in a targeted manner.

The object of the present invention is the provision of an improved method of producing associated with include ferromagnetic nanoparticles of organic particles of substrate that can be used especially as biomarkers, biosensors, hyperthermic agents or pharmaceutical carrier-material.

The task is solved according to the invention by a method of producing organic particles of the substrate connected to switchable ferromagnetic nanoparticles with a mean particle diameter in the range from 10 to 1000 nm, the ferromagnetic nanoparticles used these nanoparticles, which are not ferromagnetic, but become �ferromagnitnymi at lower temperatures, these first nonferromagnetic nanoparticles dispersed in the form of contact with the organic particles of the substrate, and further by lowering the temperature of the nanoparticles associated with the substrate particles become ferromagnetic.

Further task is solved by means of diagnostic substrate particles that contain organic particles of the substrate related to switchable ferromagnetic nanoparticles with a mean particle diameter in the range from 10 to 1000 nm, wherein the substrate particles have specific binding effect for the analyte.

Then the problem is solved by application of the switchable ferromagnetic nanoparticles, which become ferromagnetic at low temperatures, for the manufacture of a medicament for hyperthermic treatment of the human or animal body.

Further objective is achieved through medication for hyperthermic treatment of the human or animal body, containing the switchable ferromagnetic nanoparticles with a mean particle diameter in the range from 10 to 1000 nm, which become ferromagnetic at low temperatures.

According to the invention it was found that the switchable ferromagnetic nanoparticles can be applied as such to obtain biomarkers, biosensors, ISU�termicheskih agents or pharmaceutical carrier-material. Under "switchable" understand these ferromagnetic nanoparticles, which are not ferromagnetic, but become ferromagnetic at low temperatures. After obtaining the nanoparticles of the original substance they are not ferromagnetic, but only when cold. With preferably at ambient temperature (22°C) nanoparticles first neuromagnetic and become ferromagnetic when the temperature decreases to below room temperature.

By "nanoparticles" is understood such particles, which have an average particle diameter in the range from 10 to 1000 nm, preferably 20-500 nm, especially 50 to 200 nm. The average diameter of the particles is preferably determined by laser light scattering or electron microscopy. Preferably we are talking about the average mass of the particle diameter. The lower limit of particle size is limited by the fact that even when the ambient temperature or the temperature of the particles should be ferromagnetic. This is usually more true with a minimum diameter of 10 nm particles.

To obtain particles of the substrate is initially non-ferromagnetic nanoparticles are usually in the dispersion, such as a water dispersion or water-based, and in dispersed form in contact with the organic particles of the substrate. Because the nanoparticles at this point �e are ferromagnetic, can effectively prevent agglomeration of the particles and thus an increase in the average size of the particles. Later this dispersion can be applied, for example, for hyperthermia treatment.

As the organic particles of the substrate are considered any relevant substrate particles, which mediate the desired effect. While organic particles of the substrate must have the appropriate anchor groups which allow coupling with ferromagnetic nanoparticles. It may be possible, for example, that organic particles of the substrate are applied to ferromagnetic nanoparticles as a coating or film. Also possible and known to those skilled other compounds. Organic particles of the substrate can be selected from a wide range of relevant particles of the substrate. In the case of biomarkers it is, for example, the antibodies or biological or synthetic organic substances which later interact with other substances. For example, ferromagnetic nanoparticles can connect with antibodies, which in turn come into contact with antigens, so as to obtain biomarkers or biosensors. Associated with certain antibodies particles are used, for example, for magnetic diagnostics of diseases. For quantitative diagnosis is important when �to be able to use ferromagnetic nanoparticles with small particle size change, because in the end, it is considered part of the ferromagnetic nanoparticles.

Biomarkers can be used, for example, in environmental analysis, water analysis and blood, for example, proteins, carbohydrates or hormones.

Biosensors can be used to detect any biological impurities/components, e.g. in liquid or gas flows. In this case, the organic substrate particles have binding sites for the analyte or quantifiable substances. For the detection of the designated substances effective biosensors biological systems at different high integration level. Such biological systems may be, for example, antibodies, enzymes, organelles or microorganisms. Immobilized biological system biosensor interacts with the analyte. While this leads to physico-chemical changes. Determination of glucose in blood during or after surgery is possible thanks to the immobilization of the enzyme glucose oxidase. Applications for biosensors in the analysis of water and wastewater can be divided into biosensors for determination of individual components, biosensors for toxicity and mutagenicity, as well as biosensors for the determination of biochemical oxygen demand (BSB). The content of bacteria in bathing waters or wastewater can be defined�'it using the biosensor.

Concentration of penicillin in a bioreactor, which are cultivated mushroom strains can be determined using a biosensor. Biological component used in this sensor there is an enzyme acylase.

In the case of organic particles of the substrate may talk also about pharmaceutical materials-carriers that attach pharmacological active substances. This type of organic polymer particles of the substrate is described for example in WO 2008/044963. Especially should pay attention to page 16, line 18 - page 17, line 11 of this description.

Bioactive compounds, which can bind with the particles of the substrate are, for example, antigens, antibodies, nucleotides, gelling agents, enzymes, bacteria, yeast, fungi, viruses, polysaccharides, fats, proteins, hormones, carbohydrates, as well as cellular material. The latter can be used as materials of biosensors. For additional descriptions, you can pay attention to WO 2008/044963, especially page 17.

Biosensors (biochips) are generally used in the compositions of sensors for bioanalytical tasks in biotechnology. Examples are the immune samples, which are used in a wide range in clinical diagnosis for the identification of diseases or physiological States. To describe biosensors can pay�ü attention to WO 2008/044963, page 17, line 25 - page 18, line 17.

Biomarkers and biosensors are especially used to quantify or measure the concentration of biological active substances.

Eventually received organic particles of the substrate associated with ferromagnetic nanoparticles have an average particle diameter in the range of preferably from 1.1 to 5 times, particularly preferably 1.2 to 2 times the diameter of magnetocaloric particles.

First, at temperatures of 22°C or higher switchable ferromagnetic nanoparticles are preferably non-ferromagnetic and become ferromagnetic by cooling to temperatures less than 22°C.

Switchable ferromagnetic nanoparticles preferably discover Virgin-effect patterns, so that when the first cooling of the initially non-ferromagnetic nanoparticles the critical temperature of transition to the ferromagnetic state (critical temperature 1) is lower than during subsequent re-heating and cooling (critical temperature 2).

The critical temperature for 1 pass only the first cooling, while the critical temperature are 2 subsequent cycles of heating/cooling. The critical temperature 1 preferably lies below 22°C, preferably < 0°C, especially<-15°C, especially <-25°C, and cu�critical temperature 2 above 22°C, for example, body temperature ±2°C.

Switchable ferromagnetic nanoparticles can be selected from all relevant nanoparticles. Switchable ferromagnetic nanoparticles preferably contain MP and optionally Fe and/or As and preferably have Fe2P-structure or Na-Zn-13-structure. Alternatively, they may contain La, Fe and Si.

Material switchable ferromagnetic nanoparticles particularly preferably is MnFe (P/As, Si/Ge) with Fe2R-structure or MnAs with, if necessary, si and/or Fe as impurities, or LaFeSiH.

Notation "P/As" and "Si/Ge" means that can be submitted each/respectively phosphorus, arsenic or phosphorus and arsenic or silicon, germanium or silicon and germanium.

Corresponding compositions are also described in WO 2008/044963.

Switchable ferromagnetic nanoparticles preferably detect magnetocaloric properties. The nanoparticles preferably detect hysteresis and adiabatic temperature change from 2 to 6 K/Tesla, for example, a field strength of about 4 K/Tesla. Hysteresis is preferably at least 5 K.

Applied according to the invention ferromagnetic or thermomagnetic materials can be obtained by any appropriate means.

Getting ferromagnetic or thermomagnetic materials are, �of primer, with the transformation of the solid phase of the original elements or the original alloys for the material in the ball mill, the subsequent pressing, sintering and annealing in an inert gas atmosphere and subsequent slow cooling to room temperature. A method of this kind is described, for example, in J. Appl. Phys. 99, 2006, 08Q107.

Also a possible treatment for forming from the melt. Through this perhaps a more homogeneous distribution of elements, which leads to an enhanced magnetocaloric effect, see Rare Metals, vol. 25, October 2006, pages 544-549. In the method described there, the original elements of the first induction melted in a gas atmosphere of argon and then in the molten state is sprayed through a nozzle onto a rotating copper drum. Occurs by sintering at 1000°C and slow cooling to room temperature.

Then for getting you to pay attention to WO 2004/068512.

Obtained by these methods materials often exhibit high thermal hysteresis. For example, in compounds of Fe2R-type, which is replaced by germanium or silicon, there are large values for thermal hysteresis in a large range between 10 K and more.

Applied according to the invention, the material preferably detect hysteresis of at least 5, particularly preferably at least 6.5 K preferred�positive in the temperature range between the temperature of the body and above 42°C.

Preferred is a method of producing ferromagnetic or thermomagnetic material comprising the following stages:

(a) interaction of chemical elements and/or alloys in a stoichiometry which corresponds to the material on the basis of metals, in solid and/or liquid phase,

b) optionally, transferring the reaction product from stage a) in a solid body,

(c) sintering and/or annealing of a solid from stage a) or b)

(d) cooling the sintered and/or annealed solid from stage C).

Thermal hysteresis can be adjusted and can be achieved with a large magnetocaloric effect, if the materials for the metal after sintering and/or annealing quickly or slowly cooled to ambient temperature.

At the stage a) of the method, the interaction of elements and/or alloys, which are contained in the future ferromagnetic or thermomagnetic material, in a stoichiometry which corresponds to ferromagnetic or thermomagnetic material, in solid or liquid phase.

Preferably, the interaction at the stage a) is carried out by the joint heating elements and/or alloys in a closed vessel or in an extruder or transformation of the solid phase in a ball mill. Particularly preferably is the transformation of the solid phase, which occurs especially in a ball mölln�TSE. The transformation of this kind is essentially known, see the above description. Thus in the respective mass portions in the form of powder usually mixed powders of the individual elements or powders of alloys of two or more separate elements, which are presented in the future ferromagnetic or thermomagnetic material. If necessary, you can also carry out milling the mixture to obtain a microcrystalline powder mix. This powder mixture is heated, preferably in a ball mill, which leads to further reduction, as well as good mixing and reaction of the solid phase in the powder mixture. Alternative mix individual elements in the selected stoichiometry as a powder and then melted.

Are heated together in a closed container allows the fixation of the volatile components and the control of stoichiometry. Directly in a joint application of phosphorus last in an open system could easily evaporate.

The interaction follows the sintering and/or annealing of solids, and may be provided one or more intermediate stages. For example, obtained in stage (a) solid phase can be compressed before it is sintered and/or otjihase. This increases the density of the material, so that when I�eat the application, there will be high density thermomagnetic material. The pressing is in itself known and can be performed with or without assistive devices for pressing. This may apply any suitable shape for pressing. By compressing already possible to manufacture a molded body in a predetermined three-dimensional structure. For pressing may be directly followed by a sintering and/or annealing stage C) with subsequent cooling or quenching stage (d).

For nanoparticles can be added grinding.

Alternatively it is possible to apply the solid phase obtained from the ball mill, the method of forming from the melt. Methods of forming from the melt is known in themselves and described, for example, Rare Metals, vol. 25, October 2006, pages 544-549, as well as in WO 2004/068512.

By quick centrifugation of the melt (cooling of the melt on a rotating disc) to achieve high speed processing, as the subsequent sintering and annealing may be reduced. In technical scale getting ferromagnetic or thermomagnetic material becomes so much more economical. Also high speed processing spray drying leads, especially when it can be easily set to the desired particle size.

Cooling should not occur too quickly to get enough high values of Ki - �of Teresita.

Alternative b-stage) may be conducted by spray cooling, in which the melt of the composition from step a) is sprayed into the tower for spray drying. The tower for spray drying may, for example, in addition to cool. In the towers for spray drying are often achieved cooling rate in the range from 103 to 105 K/s, especially about 104 K/s. Spray cooling may occur in the electric field to obtain monodisperse particles.

Sintering and/or annealing of solids occurs in stage C) is preferably initially at a temperature in the range from 500 to 1800°C and sintering further at a lower temperature for annealing. These values are especially powders.

The sintering preferably is carried out over a time interval of 1 to 50 hours, particularly preferably 2 to 20 hours, especially 5-15 hours. The annealing is preferably conducted for a time in the range from 10 to 100 hours, particularly preferably 10 to 60 hours, particularly 30-50 hours. Exact time slots may be aligned depending on the material usage requirements.

In applying the method of forming from the melt, the time interval for sintering or annealing can greatly be reduced, for example to time intervals from 5 minutes to 5 hours, preferably 10 minutes-an hour. In compari�and normal 10 hours for sintering, and 50 hours for annealing obtained extremely favorable time/marginal advantage in time.

Sintering/annealing it comes to melting/welding of the boundaries of the nuclei, so that the material is further compacted.

By melting and rapid or slow cooling phase (b), however, can significantly lower the duration of stage C). It also makes possible a continuous ferromagnetic or thermomagnetic materials.

According to the invention particularly preferred is the sequence of the method:

(a) the conversion of solid phase chemical elements and/or alloys in a stoichiometry which corresponds to ferromagnetic or thermomagnetic material in a ball mill,

(b) forming from the melt or shaping the product obtained at stage a) to the material

c) annealing a solid from stage b) for 10 seconds or 1 minute to 5 hours, preferably 30 minutes to 2 hours, at a temperature in the range from 430 to 1200°C, preferably 800 -1000°C.

(d) quenching, or cooling the annealed solid from stage C).

Alternative in stage C) can occur grinding of the resulting layer to produce powder.

Determination of the particle size of ferromagnetic nanoparticles preferably takes place by laser light scattering as described.

Switchable ferromagnetic nanoparticles, which become ferromagnetic when the pony�starting temperature, according to the invention is preferably used for obtaining medication for hyperthermic treatment of the human or animal body. The nanoparticles are preferably magnetocaloric. Hyperthermic treatment is used especially for the treatment of cancer, as already stated at the beginning.

The invention also relates to medicaments for hyperthermic treatment of the human or animal body, comprising the switchable ferromagnetic nanoparticles, which become ferromagnetic at low temperatures.

In this case preferably particles become ferromagnetic when cooled. Directly in cancer treatment nanoparticles were to be ferromagnetic in the temperature range from 37 to 42°C. At higher temperatures, or preferably at a maximum temperature of 42°C according to the embodiment of the invention, they may lose their ferromagnetic nature. This leads to the exclusion of hysteresis in the case of overheating, so that substances lose their ferromagnetic properties and can be simply removed from the body.

This thermal exclusion must have occurred at higher temperatures than the temperatures at which cancer is destroyed.

It is especially important for all applications that the ferromagnetic nanoparticles are �ferromagnitnymi at ambient temperature (22°C) or at the temperature of use.

The preferred material is applied MnFe (P, Si), which detects the unexpected property that it after receiving at room temperature (22°C) is not magnetic. Only after he briefly cooled a few degrees below a certain critical temperature, it is magnetic at room temperature and above. The relevant properties are presented in the attached image in Fig.1. The image shows the temperature dependence of the magnetization MnFeP0,50Si0,50. Curve (1) shows the Virgin-effect, that is, the first cooling. Curve (2) shows the behavior during the subsequent heating, (3) - if, following cooling. The hysteresis of the ferromagnetic material, which more accurately To 5, very well recognizable.

Non-magnetic property in the beginning can greatly simplify the binding of antibodies, so that the magnetic biomarker can be obtained much easier than before. For application - in vitro biocompatibility is vital so that you can connection with any appropriate organic substrate particles. When applied in vivo had to pay attention on good compatibility with organic particles of the substrate with a human or animal body. Along with hypothermic depressed�eat cancer particles according to the invention can also be used as NMR contrast agents.

Hyperthermia can be additionally useful that is presented on the figure the material, after it has once been heated above T2that is no longer ferromagnetic and thus can be easier removed.

The invention disclosed by the following examples.

Example 1

Vacuumed quartz ampoules which contained a compacted samples MnFePGe, maintained for 10 hours at 1100°C to bake the powder. This sintering was followed by annealing at 650°C for 60 hours to achieve homogenization. Followed by slow cooling in the furnace to room temperature. XRD samples show that all samples crystallize in the structure of Fe2The p-type. Thus were obtained the following composition:

Mn1,1FeFor 0.9P0,81Ge0,19; Mn1,1FeFor 0.9P0,78Ge0,22; Mn1,1FeFor 0.9P0,75GeOf 0.25and Mn1,2FeThe 0.8P0,81Ge0,19. The observed values for thermal hysteresis for each of these samples is greater than 10 K. By means of rapid cooling, the hysteresis can be reduced.

Thermal hysteresis was determined in a magnetic field of 0.5 Tesla.

The Curie temperature can be set by changing the ratio of Mn/Fe and Ge concentration, the value for thermal hysteresis.

Curie temperature and thermal hysteresis reduce�are with increasing ratio of Mn/Fe. As a result MnFePGe-compounds show relatively large values of MCE-magnetocaloric effect at low field.

Example 2

Material MnFeP0,50Si0,50received as described in example 1. Temperature dependence of magnetization is shown in Fig.1.

1. The method of producing organic particles of the substrate related to switchable ferromagnetic nanoparticles with a mean particle diameter in the range from 10 to 1000 nm, characterized in that the ferromagnetic nanoparticles used these nanoparticles, which are not ferromagnetic, but become ferromagnetic when the temperature decreases, these first nonferromagnetic nanoparticles dispersed in the form of contact with the organic particles of the substrate, and further by lowering the temperature associated with the substrate particles, the nanoparticles become ferromagnetic, and switchable ferromagnetic nanoparticles initially at temperatures from 22°C or higher are not ferromagnetic, and become ferromagnetic by cooling to temperatures less than 22°C, with a switchable ferromagnetic nanoparticles contains Μn and additionally Fe and/or As and preferably has a Fe2P-structure or Na-Zn-13-structure, or contains La, Fe and Si.

2. A method according to claim 1, characterized in that the organic particles substr�the one related to switchable ferromagnetic nanoparticles are biomarkers, biosensors, hyperthermic agents or pharmaceutical carrier materials.

3. A method according to claim 1, characterized in that the switchable ferromagnetic nanoparticles has MnFe(P/As, Si/Ge) with Fe2P-MnAs structure or, if necessary, with si and/or Fe as impurities, or LaFeSiH.

4. Method according to one of claims. 1-3, characterized in that the switchable ferromagnetic nanoparticles exhibit magnetocaloric properties.
5 Diagnostic substrate particles that contain organic particles of the substrate related to switchable ferromagnetic nanoparticles with a mean particle diameter in the range from 10 to 1000 nm, wherein the substrate particles have specific binding activity for the analyte and a switchable ferromagnetic nanoparticles initially at temperatures from 22°C or higher are not ferromagnetic, but ferromagnetic by cooling to temperatures less than 22°C, and at first nonferromagnetic nanoparticles dispersed in the form of contact with the organic particles of the substrate and in the future by lowering the temperature of the nanoparticles associated with the substrate particles become ferromagnetic.

6. Diagnostic substrate particles according to claim 5, characterized �eat what they exhibit the characteristics defined in one of claims. 2-4.

7. The application of the switchable ferromagnetic nanoparticles, which become ferromagnetic at low temperatures, to obtain the drug for hyperthermic treatment of the human or animal body, the switchable ferromagnetic nanoparticles initially at temperatures from 22°C or higher are not ferromagnetic and become ferromagnetic by cooling to temperatures less than 22°C, and at first nonferromagnetic nanoparticles dispersed in the form of contact with the organic particles and in the future by lowering the temperature of the nanoparticles associated with the substrate particles become ferromagnetic.

8. The use according to claim 7, characterized in that the switchable ferromagnetic nanoparticles are magnetocaloric.

9. The use according to claim 7 or 8 for the treatment of cancer.

10. Medication for hyperthermic treatment of the human or animal body, containing the switchable ferromagnetic nanoparticles with a mean particle diameter in the range from 10 to 1000 nm, which become ferromagnetic at low temperatures, and switchable ferromagnetic nanoparticles initially at temperatures from 22°C or higher are not ferromagnetic, but ferromagnetic through the OHL�statement to temperatures less than 22°C, and at first nonferromagnetic nanoparticles dispersed in the form of contact with the organic particles and in the future by lowering the temperature of the nanoparticles associated with the substrate particles become ferromagnetic.



 

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EFFECT: simple production of babbit alloy per one operation at same equipment at more close temperature, exclusion of calcium and natrium losses.

4 cl, 1 tbl, 2 ex

FIELD: metallurgy.

SUBSTANCE: invention relates to material for cables based on aluminium alloy and to a method for its obtaining. Aluminium-based alloy contains the following, wt %: 0.3-1.2 Fe, 0.03-0.10 Si, 0.01-0.30 rare-earth elements Ce and La, inevitable impurities - less than 0.3 and aluminium is the rest; content of Ca in impurities is 0.02%, and content of any other impurity element - 0.01%. An alloy obtaining method involves preparation of a melt by melting of 92-98 weight parts of aluminium melt containing 0.07-0.12% Si and 0.12-0.13% Fe, and 0.73-5.26 weight parts of Al-Fe melt with content of Fe of 20-24%, heating of melt to 720-760°C, addition of 1-3 weight parts of Al alloy - 9-11% rare-earth elements Ce and La and 0.17-0.67 weight parts of Al alloy - 3-4% B, addition of 0.04-0.06 weight parts of a refining agent and refining during 8-20 minutes, exposure at the temperature during 20-40 minutes, casting and further semi-annealing at the temperature of 280-380°C during 4-10 hours with natural cooldown to ambient temperature.

EFFECT: conductor made from aluminium alloy has a high degree of elongation and has good safety and stability at application.

6 cl, 4 ex

FIELD: metallurgy.

SUBSTANCE: invention relates to metallurgy, and namely to magnesium alloy suitable for use at high temperature. Method for magnesium alloy production includes magnesium or magnesium alloy melting with creation of the liquid phase, addition of 0.5-4.0 wt % of CaO to the melt surface, surface mixing ensuring in principle complete consumption of CaO in magnesium, creation of calcium compounds (Ca) with metal or other alloying elements in magnesium alloy and melt solidification.

EFFECT: alloy has high mechanical properties at high temperature.

16 cl, 15 dwg, 5 tbl

FIELD: metallurgy.

SUBSTANCE: invention relates to metallurgy, namely to manufacturing of the cast composite material (CCM) based of Al alloy to manufacture cyclic and thermal loaded to 230°C aviation parts - blades of fans and LP compressor stages of advanced aviation engines and gas transfer units. The cast composite material based on Al alloy of Al-Cu-Mg-Ag system contains reinforcing discrete ceramic parts of Al oxide with grain size 10-100 nm in amount 0.2-10 % by volume and Ti diboride with grain size 0.5-1.5 micron in amount when Ti content in alloy is 0.1-0.2 wt %. Method of CCM manufacturing includes manufacturing of modified Al-Ti-B foundry alloy by means of dry mechanical and friction treatment in grinding and mixing device of the coarse powder or shaving of Al-Ti-B foundry alloy selected from row AlTi3B1, AlTi5B0.2, AlTi5B0.6, AlTi5B1, injection of the specified quantity of the discrete ceramic particles of Al oxide with grain size 10-100 nm, mixing until reception of the uniform consistency, further high energy machining of the received mixture, its briquetting using the cold isostatic pressing under pressure 200-400 MPa to achieve density exceeding 60% of the theoretical density, the received brickets supply to the melted Al alloy of Al-Cu-Mg-Ag system overheated to 750-850°C, holding at specified temperature for 20-60 minutes, pouring with solidification rate at least 70 K/s, and final heat treatment by homogenising annealing at 450-500°C for 2-24 hours, heating to 510-520°C with holding for 1-5 hours, water quenching and further artificial ageing at 190-250°C for 2-10 hours.

EFFECT: increased high temperature strength and crack strength of CCM due to uniform distribution of nm size ceramic particles of Al oxide in the casting volume.

2 cl

FIELD: metallurgy.

SUBSTANCE: invention relates to metallurgy, in particular to method of Al alloys affinage and modification. Method includes metal melting, melt treatment by nanosecond electromagneticpulses (NSEMP) for 15 minutes, and pouring in moulds, at that prior to treatment using NSEMP the melt is treated by the affinage salts, and during treatment or after NSEMP treatment the melt is subjected to evacuation for 15 minutes.

EFFECT: increased quality of Al alloy castings due to gas porous exclusion.

4 dwg

FIELD: metallurgy.

SUBSTANCE: invention relates to metallurgy, and namely to nickel-based alloys to manufacture mechanical components of the turbomachines. Nickel-based super alloy for the mechanical component of the turbomachines contains, wt %: chrome - from 3 to 7, tungsten - from 3 to 15, tantalum - from 4 to 6, aluminium - from 4 to 8, carbon below 0.8, nickel and admixtures - rest. Mechanical components made from the specified alloy can operate under high temperatures.

EFFECT: alloy is characterised by high mechanical, chemical and thermal strength.

10 cl, 8 dwg

FIELD: metallurgy.

SUBSTANCE: invention relates to metallurgy, in particular to magnesium alloy suitable for use at ambient temperature. The method of obtaining of magnesium-based alloy includes the smelting-of magnesium or magnesium alloy, addition from 0.05 wt % up to 1.2 wt % of calcium oxide (CaO) to the melt surface, agitation with ensuring, in essence, of complete consumption of CaO, ensuring of interaction of calcium (Ca), obtained as a result of the named reaction, with the named melt, alloy casting and solidification.

EFFECT: alloy is characterised by improved characteristics of tearing strength, yield stress, elongation at ambient temperature.

11 cl, 15 dwg, 5 tbl

FIELD: metallurgy.

SUBSTANCE: composite material contains the following, wt %: industrial oil 1.0-2.0; carbon nanomodifiers of fulleroid type 0.001-0.050; alloyed steel powder is the rest.

EFFECT: increasing wear resistance and improving operating reliability.

2 tbl

FIELD: metallurgy.

SUBSTANCE: invention relates to powder metallurgy, in particular to powder production for application of wear- and corrosion-resistant coatings with high adhesive and cohesive strength by method of cold gas-dynamic spattering. The composite nanostructured powder for coatings application by the method of cold gas-dynamic spattering comprises particles containing metal core out of Hadfield steel, clad layer with thickness 4-8 mcm out of aluminium powder, diffusion layer out of intermetallic compounds with thickness 0.6-1.2 mcm created at border of the core and clad layer during annealing, and reinforced surface layer created during interaction of the clad layer and oxide reinforcing agent comprising nanoparticles 10-100 nm, at that the volume share of the oxide reinforcing agent in the clad layer is 30-40%.

EFFECT: coatings made from the suggested composite nanostructured powder have high adhesive and cohesive strength, uniform hardness distribution through the coating cross-section.

2 ex

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