Disinfectant for sanitation of veterinary supervision facilities
FIELD: veterinary medicine.
SUBSTANCE: disinfectant for sanitation comprises colloidal silver stabilized with didecyldimethylammonium bromide, alkyl polyglucoside, alkyl-fraction C4-C10 and water in the following ratio of components, wt %: colloidal silver 0.004-0.04, didecyldimethylammonium bromide 0.4-0.8, alkyl polyglucoside, alkyl-fraction C4-C10 0.3-0.6, water - the rest.
EFFECT: use of the invention enables to increase the biocidal activity while reduction of toxicity.
2 cl, 9 tbl, 4 ex
The technical field to which the invention relates
The invention relates to sanitation, in particular for disinfecting tool for rehabilitation of objects of veterinary supervision, and can be used as a disinfectant for sanitation of animal facilities, enterprises of food and processing industry.
For the production of disinfectants most commonly used substances of the following chemical groups: hydrogen peroxide, Halogens, alcohols, aldehydes and dialdehyde, guanidine, surface-active substances. In most cases, preference is given to a combination product containing 2-3 compatible active substances from different chemical groups of compounds (Mashneva L. V. Disinfectants - what to choose? / L. V. Mashneva // Meat technology. - 2011. - No. 9. Pp. 66-68).
Known disinfectant composition comprising hydrogen peroxide, water-soluble sodium salts of ethylenediaminetetraacetic acid, surfactants, fragrance and a solvent (patent RU №2360416, CL A01N 25/22, A01N 43/14, A01N 33/08, AR 1/00, publ. 10.07.2009).
The disadvantage of this composition is that the complexing agent requires a single mechanical activation, resulting in solutions subsequent dilution not subject to, which makes their storage and use.
Known dezinficiruy�e detergent contains alkyldimethylbenzylammonium chloride, , or polyethyleneperfolat, or a mixture thereof, and nonionic surfactants, high molecular polyoxyethylene with a molecular weight of 1×106×109 and/or high molecular weight polyacrylamide with a molecular weight of 1×106-20×109, with the following ratio of components, wt.h.:
|or a mixture thereof in any ratio||0,01-33,0|
|Non-ionogenic surface-active substance||0.01 to about 30.0|
|High molecular polyoxyethylene|
|and/or high molecular weight polyacrylamide||0,01-2,0|
As water is partially or completely can be used water containing silver ions, obtained by electrolysis upon dissolution of Serebryanskaya, and/or water, were in contact with stones, and/or water to which was added silver nanoparticles (patent RU №2315626, CL A61L 2/16, C11D 3/48, publ. 27.01.2008).
The disadvantage of this disinfectant is that part of water to dilute the silver is taken without a certain concentration, which can lead to increased microbiological indicators in solutions containing the same amount of the main active ingredient.
The closest technical effect is a disinfectant for treatment of skin containing colloidal silver, at least one cationic surface-active agent, additives and water in the following ratio of components, wt.%:
|cationic surface-active agent||Of 0.01-25|
|water and additives||to 100|
As cationic surfactants can be used: chloride benzyldimethyl[3-(myristoylation)propyl]ammonium (KBDMAP), salt, alkyldimethylbenzylammonium, dioktyldimethylammonium, dodecyldimethylamine, OCTI�of decollimation, Didecyl-methyl-poly(hydroxyethyl)ammonium, alkyldimethylbenzylammonium, alkyldimethyl(ethyl benzyl)ammonium, dimethylbenzylamine, alkyltrimethylammonium, for example chloride, propionates, methylsulfate, octenidindihydrochloride, N,N-bis(3-aminopropyl)dodecylamine, poly(hexamethylenebiguanide)chloride, phosphate, gluconate, monohydrate and other polyalkylbenzene, phosphate poly(4,9-dioxa-dodecane-1,12-guanidine), salt polyhexamethyleneguanidine - hydrochloride, gluconate, and others, as well as other cationic surfactants.
The silver content in a decontaminant preparation according to the invention can range from 10-5wt.% to 0.1 wt.%, and in concentrate disinfectant drug which must be diluted before use to 0.5 wt.%.
The content of cationic surfactant or the total content of several cationic surfactants in antibacterial drug according to the invention is from 0.01 wt.% up to 1 wt.%, and in concentrate disinfectant drug which must be diluted before use to 25 wt.%.
As additives there may be used propylene glycol (humectant and antibacterial agent), polyethylene glycol (thickener) salt and acid food (pH regulator disinfectant) selected from the group comprising:sodium or potassium salt of citric acid, as well as the sodium or potassium salt of lactic acid (patent RU №2427380, CL. AC 33/38, AK 31/14, A61L 2/16, AR 17/02, publ. 27.08.2011).
The disadvantage of this disinfectant is low foaming effect.
In common with the claimed means are colloidal silver and cationic surfactant. Unlike the prototype of the inventive disinfectant for sanitation of objects of veterinary supervision is the presence of additional non-ionic surfactants of alkylpolyglucoside that allows you to quickly form a stable foam and degrease surface, which increases the quality of disinfection.
Brief description of the drawings and other materials
In table. 1 given disinfectant to cleanse the objects of veterinary surveillance, susceptibility of the microorganism Escherichia coli disinfectant-for the rehabilitation of objects of veterinary supervision.
In table. 2 - also, the sensitivity of culture of Escherichia coli to different concentrations of the disinfectant for the rehabilitation of objects of veterinary supervision.
In table. 3 - also, hematological parameters of mice (n=8).
In table. 4 - also, leukocyte formula of white mice, % (n=8).
In table. 5 - also, the experimental setup and the results of studies of acute toxicity of disinfection facilities�VA for rehabilitation of objects of veterinary supervision on white mice.
In table. 6 - also, the acute toxicity of the disinfectant for the rehabilitation of objects of veterinary supervision after a single intragastric introduction to white mice (mg/kg).
Chart 7 - also, a graphic image of the toxicity of the disinfectant for the rehabilitation of objects of veterinary supervision and calculation of LD16(punched 4) and LD84(punched 6) by the method of probit analysis (A. A. Stupnikov, 1975).
In table. 8 - also, the test results disinfectant for sanitation of objects of veterinary supervision in a production environment.
In table. 9 - also, the indicators of the quality of milk of cows after the test disinfectant for sanitation of objects of veterinary supervision (n=40).
Disclosure of the invention
The object of the invention is to develop a highly efficient disinfectant, environmentally safe, does not adversely impact on the equipment, animals and people and having good detergent properties. To do this in a disinfectant as the active active substance used for the bromide complex of dodecyldimethylamine, alkylpolyglucoside and colloidal silver.
The technical result that can be achieved by using the proposed invention is to increase the biocidal action of the disinfectant, reducing the�lichnosti by the decrease in concentration of the active substance, and improving cleaning properties due to the introduction of alkylpolyglucoside.
The technical result is achieved by using a disinfectant to cleanse the objects of veterinary supervision, including colloidal silver, bromide stabilized dodecyldimethylamine, and water, characterized in that it further introduced alkylpolyglucoside, alkyl-faction With4-C10with vigorous stirring and the treatment of the reaction mixture external physical effects, namely thermal, ultrasonic and ultraviolet radiation, with the following ratio of components, wt.%:
|Colloidal silver||Of 0.004-0.04 to|
|Alkylpolyglucoside, alkyl-faction With4-C10||Of 0.3-0.6|
The inventive disinfectant for sanitation of objects of veterinary supervision is an aqueous solution of yellow color, odorless, has a strong bactericidal effect, has no local irritative and sensitizing days�Vija, it gives the possibility to use it in the presence of animals; has a pronounced cleaning properties and does not cause damage to machined surfaces.
The effectiveness of disinfectants is determined by many factors: the composition, the content of active substance, production technology, microflora on the objects to be processed, the method of disinfection (Noskov A.V. New disinfectants / V. A. Noskov]. / / - 2009. - No. 9. - Pp. 43-45.).
Quaternary ammonium compounds from the group of cationic surfactants and have disinfectant and cleaning effect. Can have a neutral pH (5.5-7.5) that does not require specialized protection of the skin and mucous membranes. Do not damage the surface. In addition to the high bactericidal activity of preparations containing Quaternary ammonium compounds, no inhalation toxicity (Fadeeva L. L. Cationic surface-active biocidal substances as the basis of modern antiseptics / L. L. Fadeev and [et al.] / / veterinary medicine. - 2004. - No. 5. - Pp. 41-43; Khudyakov A. A. Effective disinfection and selection of disinfectant / A. A. Khudyakov // veterinary medicine. - 2010. - No. 2. - P. 18-22).
Bactericidal action of cationic surfactants is associated with inactivation of cellular synthesis of enzymes, denaturation of cellular proteins and impaired permeability to�mocnych membranes (T. A. Fomina Sanitation as a guarantee of high quality products / T. A. Fomin, Y. M. Minaev // Meat technology. - 2012. - No. 1. - Pp. 42-43).
Alkylpolyglucoside is a nonionic surface-active substance that forms a stable foam and has good detergent properties. In addition, alkylpolyglucoside biodegradable as it is produced from vegetable raw materials, therefore, it does not harm animals, service personnel and the environment.
Preparations based on silver provide an antibacterial effect on a wide range of bacteria by destroying the cell membrane of bacteria and preventing their growth. Colloidal silver destroys up to 99.9% of bacteria and prevents odors (Smirnov A. M. the animal health aspects of the use of nanosilver / A. M. Smirnov and [et al.] / / Vetcom. - 2011. - No. 3. - P. 18-19).
The mechanism of action of this tool is that the cationic surfactant is adsorbed on the cell membrane and colloidal silver enters the nucleus, this leads to the lysis of cell membranes, disruption of osmotic exchange, precipitation of the protein, the destruction of genetic information DNA and as a consequence the death of the bacteria, the effect of alkylpolyglucoside provides the formation of froth, contributing to the preservation of concentration are�his substances on the treated surface.
The essence of obtaining a disinfectant for sanitation of objects of veterinary supervision is as follows: to a water solution of sodium borohydride was added a solution of silver nitrate in the presence of the bromide dodecyldimethylamine and alkylpolyglucoside with vigorous stirring and the treatment of the reaction mixture external physical effects, namely thermal, ultrasonic and ultraviolet radiation. Before using the drug was diluted in 100 to 1000 times.
The implementation of the invention
Examples of specific performance testing and disinfectant for sanitation of objects of veterinary supervision.
Disinfectant for sanitation of objects of veterinary supervision prepared as follows. In 96 ml of water is injected 1.6 ml of 6% solution of bromide of didecyldimethylammonium and 2.2 ml of a 4.5% solution of alkylpolyglucoside, dissolved stoichiometrically required for reduction of silver nitrate amount of sodium borohydride (0.02 ml 25% solution). Then with vigorous stirring and the treatment of the reaction mixture external physical effects, namely, thermal, ultrasonic and ultraviolet radiation, in the reaction mixture dropwise injected with 0.02 ml of 0.22% of the silver nitrate solution. Stirring was continued until the reaction is completed. As a result yielding�tsya following ratio of components, wt.%:
|Colloidal silver||Of 0.0004|
|Alkylpolyglucoside, alkyl-faction With4-C10||0,1|
This tool, when testing the antimicrobial activity suspension method on cultures of Escherichia coli (strain 1257) and Staphylococcus aureus (strain 906) showed bactericidal activity against gram-positive bacteria is 87% and against gram - 85% after 5 min exposure.
Tested under production conditions give the following results: quality control of disinfection on Escherichia coli and Staphylococcus efficiency of disinfection naturally contaminated objects is 81%, exposure time = 30 min at a concentration of 0.25%.
Carried out analogously to example 1, but take the following quantities of substances: water - 86 ml of a solution of bromide of didecyldimethylammonium - 6,7 ml of a solution of alkylpolyglucoside - 6,7 ml of a solution of sodium borohydride and 0.2 ml and 0.2 ml of silver nitrate solution in the following ratio of components, wt.%:
|Alkylpolyglucoside, alkyl-faction With4-C10||0,3|
Disinfectant for sanitation of objects of veterinary supervision according to example 2 shows that its effectiveness against the bacteria Escherichia coli (strain 1257) and Staphylococcus aureus (strain 906) is increased in comparison with example 1 at 100%, starting with 5 min of exposure.
The effectiveness of disinfection naturally contaminated objects in a production environment for quality control of disinfection on Escherichia coli and Staphylococcus is 100% at 30 min exposure at a concentration of 0.25%.
Carried out analogously to examples 1 and 2, but take the following quantities of substances: water, 70 ml, solution of bromide of didecyldimethylammonium with 13.4 ml of a solution of alkylpolyglucoside with 13.4 ml of a solution of sodium borohydride to 2.0 ml, and 2.0 ml of a solution of silver nitrate in the following ratio of components, wt.%:
|Alkylpolyglucoside, alkyl-faction With4-C10||0,6|
Obtained disinfectant according to example 3 has a pronounced (100%) bactericidal activity against gram-positive and gram-negative bacteria (Escherichia coli (strain 1257) and Staphylococcus aureus (strain 906)) in assessing suspension method, starting with 5 min of exposure.
When tested tools in a production environment, the effectiveness of disinfection naturally contaminated objects is 100% quality control of disinfection on Escherichia coli and staphylococci, exposure time = 30 min at a concentration of 0.25%.
Carried out analogously to example 1, but take the following quantities of substances: water to 20.0 ml of a solution of bromide of didecyldimethylammonium - 20,0 ml of the solution of alkylpolyglucoside - 20,0 ml of a solution of sodium borohydride to -20.0 ml and 20.0 ml of a solution of silver nitrate in the following ratio of components, wt.%:
|Alkylpolyglucoside, al�Il-fractions With 4-C10||0,9|
The disinfectant of example 4 shows that its bactericidal activity against E. coli and S. aureus decreased by 6% in comparison with example 3, and is 94% when assessing suspension method, starting with 5 min of exposure, which is associated with high concentrations of active ingredients in disinfectant, resulting in reduced synergistic actions of its components and reduce the germicidal effectiveness.
When disinfection naturally contaminated objects in a production environment, the processing efficiency is 92% at a concentration of 0.25% at the exposition time of 30 min.
Thus, the optimal are examples 2, 3.
Disinfectant for sanitation of objects of veterinary supervision was tested in the laboratory for pathogenic microorganisms and laboratory animals and in production in the following ratio of components, wt.%:
|Didecyl dimethyl ammonium bromide||0,6|
|Alki�polyglucoside, alkyl-fractions With4-C10||0,45|
When determining the sensitivity to the tested drug to cultures of Escherichia coli strain 1257 as the culture medium used mesopatamia broth (BCH). A broth culture of pre-diluted saline solution to a cell concentration of 5·106/ml. Scheme of the experiment is presented in table. 1.
The contents of the tubes are mixed by shaking and incubated in a thermostat at 37°C for 24 h. after the indicated time of the first three tubes do the seeding on nutrient medium in Petri dishes and placed for 24 h in a thermostat at 37°C.
In a day record the changes that occurred in the vials: the first vial of broth remains clear, in the second tube BCH slightly cloudy in the remaining broth tubes becomes stable turbid. Then do the seeding of the first three test tubes culture media BCH in a Petri dish 0.1 ml and placed in a thermostat at 37°C for 24 h.
After a specified time see the reaction of the microorganisms Escherichia coli at different concentrations of the disinfectant for the rehabilitation of objects of veterinary supervision. The results of these studies are presented in table. 2.
As can be seen from table 2, when the concentration of colloidal silver is 4.4·10-5mol/l, the growth of microorganisms in a nutrient medium is absent; when the concentration of colloidal silver is 4.4·10-6mol/l - there is a slight growth of microorganisms Escherichia coli; at a concentration of 4.4·10-7mol/l have seen a rapid growth of bacteria colonies.
Thus, the minimum inhibitory concentration of the disinfectant for the rehabilitation of objects of veterinary supervision is 4.4·10-5mol/L.
The experience of finding the maximum tolerated dose (MTD) is carried out on clinically healthy white mice weighing 20-22 g. the Starting dose for finding the minimum toxic dose (maximum tolerated) is 100 mg/kg of body weight in group 1, in which it is applied, no change in behavior and physiological state of mice. In groups of 2-8, in which the injected dose 200, 300, 400, 500, 600, 700 and 800 mg/kg, respectively, also no visible deviations are not marked. Dose 900 mg/kg, injected into mice of the 9th group, although not causing the death of any one of the eight animals, but after the introduction see: rapid breathing and heartbeat, aggressive behavior, followed by periods of deep oppression, and the state of oppression lasts 1.5-2 h. Then, all mice in the group come to its normal state and takes the�up with food and water. Marked changes in haematological parameters (table. 3, 4).
In the analysis of hematological parameters found that the number of red blood cells in groups of No. 1-7 and No. 10 is in the normal range, while in No. 8-9 it is reduced below normal and is 17,98 and 29,94% respectively less compared to control.
The hemoglobin level decreased in groups No. 6-9 on of 21.15%, 23%, 26,59 and 31,23% for the control group.
There is an increase in the number of cells in groups No. 7-9, which is 16,07%, 31 and 35 and 36,05% respectively less than the control.
These leukocyte and platelet count are all experimental and control groups within the physiological norm.
Since the test dose is 900 mg/kg, register phenomena and changes in hematological parameters that indicate poisoning in laboratory animals, but the death is not observed, this dose is taken as the maximum tolerated (MTD) and starting to conduct experiment to determine lethal doses (table. 5).
To determine the lethal doses of the drug used clinically healthy white mice weighing 20-22 g. the study was conducted according to the "guidelines for the evaluation of the toxicity and danger of disinfectants" (MU 1.2.1105-02. - M., 2002.). The method of administration chosen intragastric, because this tool is designed to facilitate�meant for processing agricultural premises equipment, feeders and drinkers, with which the animals take up food and water. After intragastric administration of the drug in the greatest possible quantities of animal death is not observed, the results of a study on acute toxicity by the enteral method of administration are presented in table. 6 and 7 on the chart.
The object of study in a production environment choose the model barn in the SEC "Novomarjevskoj" Shpakovsky district. A new means test in of 0.025 to 0.5% concentrations. The concentrated solution is diluted with tap water. Disinfection is carried out by atomized irrigation predetermined concentrations of the solution after preliminary mechanical cleaning of the treated surfaces.
The quality of disinfection is controlled by selection of bacteria E. coli and Staphylococcus from swabs with naturally-contaminated surfaces in the room. The tests are carried out in accordance with the "rules of disinfection and desinvasion of objects of state veterinary supervision", M., 2002, "Recommendations for the sanitary-bacteriological examination of swabs from the surface of objects subject to veterinary supervision", M, 1988, Control are the swabs from surfaces, taken prior to disinfection.
Treatment disinfectant for sanitation of objects of veterinary supervision is carried out in about�the presence of animals under the scheme, specified in the table. 8.
When tested at 0.25% concentration of a new disinfectant for sanitation of objects of veterinary supervision after 10 min exposure on the treated objects not allocated E. coli, but notes the presence of staphylococci on the floor, walls and partitions.
The test of a 0.5% concentration at 10 min exposure shows that disinfection is achieved only against Escherichia coli.
The complete disinfection of all facilities in the calf shed is achieved by exposure for 30 and 60 min with solutions of 0.25 and 0.5% concentrations after a single irrigation quality control of disinfection by selection of E. coli and S. aureus.
Thus, the experimental results show that the new disinfectant for sanitation of objects of veterinary supervision has pronounced bactericidal activity at 0.25% concentration (drug) exposure time = 30 min.
Take into account the indicators of the quality of milk of cows after the test disinfectant for sanitation of objects of veterinary supervision in a production environment (table. 9).
The amount of nonfat milk residue is increased by 1.46 per day and 2,47% after 5 days after treatment to data samples taken prior to disinfection of the barn.
The fat content in milk samples policereport 24 h and 5 days after treatment, increases by 1.68 and 4,84%, respectively.
Marked increase of protein in the milk relative to the data received prior to rehabilitation facilities, 1.25 and 11.2% after 1 and 5 days.
The density of milk is raised by 1 unit in 5 days after disinfection and is 1031 kg/m3before treatment and after treatment it is 1030 kg/m3.
Acidity after treatment does not vary by more than 10% as upwards and downwards and is 17.7 and 17.1°T.
The number of somatic cells after disinfection of the premises is reduced by 5,67 and 5.9% after 24 h and 5 days relative to the number of somatic cells present in milk prior to processing of the barn.
The data of all samples taken before and after treatment are within normal limits and the milk complies with GOST R 52054-2003.
The advantages of the proposed disinfectant for sanitation of objects of veterinary supervision in that it contains the complex disinfectant natural origin, cationic and nonionic surface-active substances with powerful biocidal action. The silver in the composition of the disinfectant to cleanse the objects of veterinary surveillance is in nanoscale. The increase disinfection capacity is achieved by the synergistic action of the components than the conditioned mind�isenia the concentration of active ingredient. As a result of the proposed disinfectant for sanitation of objects of veterinary supervision has pronounced properties to the suppression of pathogenic microorganisms and low toxicity for warm-blooded. Alkylpolyglucoside promotes the formation of stable foam, which when processing disinfected surfaces provides a more prolonged contact of the active ingredients with pathogenic microorganisms, which increases the quality of disinfection.
The invention compared with the prototype and other technical solutions have the following technical advantages:
- enhance biocidal action;
- reduction of toxicity to warm-blooded;
- persistent foaming;
- ease of use;
- reduction of economic costs;
- absence of corrosive action.
1. Disinfectant for sanitation of objects of veterinary supervision, including colloidal silver, bromide stabilized dodecyldimethylamine, and water, characterized in that it further injected into a means of alkylpolyglucoside, alkyl-faction WithA 4With10with the following ratio of components, wt.%:
|Colloidal silver||Of 0.004-0.04 to|
|Alkylpolyglucoside, alkyl-faction With4-C10||Of 0.3-0.6|
2. Disinfectant for sanitation of objects of veterinary supervision according to claim 1, characterized in that before use, dilute 100 to 1000 times.
SUBSTANCE: to increase the hatching and liveability of chickens by treating the hatching eggs of poultry, their surface is treated with an aqueous solution of the preparation based on milk whey with lactulose and quaternary ammonium compound in the following ratio, wt %: milk whey 30-35, lactulose 5-10, quaternary ammonium compound trimethyl octadecyl ammonium bromide 40-45, water - the rest. The hatching eggs 2-4 hours prior to placement them for incubation are treated with 0.1-0.2% aqueous solution of the preparation.
EFFECT: invention provides environmental safety.
SUBSTANCE: invention relates to disinfection and represents a composition of a polymer disinfecting formulation for the creation of films, providing the protection and disinfection of surfaces inside hermoclosed volumes. The composition contains potassium fluoride peroxosolvate in an amount of 1.0 wt %, polyvinyl alcohol in an amount of 1.0-2.0 wt %, polyvinylpyrrolidone in an amount of 1.0 wt %, glycerol in an amount of 0.5 wt % and distilled water in an amount up to 100.0 wt %.
EFFECT: creation of film coatings with sporicidal, bactericidal and fungicidal properties.
13 ex, 3 dwg
SUBSTANCE: group of inventions relates to a method of decontaminating products or materials infected with prions, and is intended for decontaminating medical or medical surgical devices at risk, decontaminating work surfaces, decontaminating animal meal or other contaminated products of animal origin. The step for decontaminating products or materials infected with pathogenic agents responsible for prion diseases comprises placing them in contact with a solution containing copper (Cu) and/or derivatives thereof. Said copper and/or derivatives thereof are present in an amount of at least 500 mcM.
EFFECT: use of the group of inventions improves efficiency of decontaminating infected products or materials.
7 cl, 4 ex
SUBSTANCE: method for making a plate from modified xenogeneic enteric submucosa involves mechanical evacuation of small bowel, processing in hypertonic saline in a combination with ultrasonic exposure, enzymatic treatment, subsequent washing in acetic acid and sodium hydrocarbonate, sodium chloride processing, additional ultrasonic exposure and enzymatic treatment, storage in acetic acid and sodium hydrocarbonate, storage in an antimicrobial agent and multiply changed ascending glutaric dialdehyde. The biotissue is stored in multiply changed ascending glutaric dialdehyde in the melted form between the two plates of porous non-woven material.
EFFECT: preparing the non-immunogenic biomaterial uniformly cross linked throughout with particularly damaged collagen structure that provides the fast recipient's cell penetration into the transplant and smooth invasion of vessels and tissues in the postoperative period.
SUBSTANCE: what is described is a composition for an antimicrobial coating containing inorganic substance nanoparticles, an active substance, a binding agent and a solvent. As the inorganic substance, the composition contains silicone dioxide; the active substance is presented by a mixture of quaternary ammonium compound and chlorhexidine; the solvent is a mixture of ethyl cellosolve and butyl cellosolve; the binding agent is a mixture of polymethylphenylsiloxane resin and butyl/methyl methacrylate copolymer in the following proportions, wt %: butyl/methyl methacrylate copolymer 1.70-10.0, polymethylphenylsiloxane resin 5.0-20.0, silicone dioxide 0.5-3.0, chlorhexidine (20% aqueous) 3.0-8.0, quaternary ammonium compound 0.5-3.0, ethyl cellosolve 20.0-50.0, butyl cellosolve to 100%.
EFFECT: providing the water-stability of the long-action antimicrobial coating, ecological safety and applicability for porous surface finish.
4 cl, 5 tbl, 1 ex
SUBSTANCE: set task is solved by application of final slag, formed in production of ferrovanadium by alumino-silicothermic method as bactericidal material.
EFFECT: extension of raw material resources for bactericidal materials.
SUBSTANCE: method includes forming, on a surface, a coating from a dimethylalkylbenzylammonium chloride complex containing a C10-C14 alkyl group or a mixture of C8-C16 alkyl groups with a copolymer of styrene and maleic anhydride, which is subjected to preliminary chemical modification to open anhydride rings to form carboxyl groups, 50-60% of which are neutralised to form carboxylate groups, or a mixture of said complex with polyvinyl butyral, in the following ratio, wt %: antiseptic polymer complex 25-40, polyvinyl butyral 60-75.
EFFECT: full prolonged protection of articles made of aluminium alloy from fouling by microorganisms, which prevents corrosive change of the surface of said alloys.
28 ex, 3 tbl
SUBSTANCE: invention relates to means of purifying and disinfecting different types of water. Described is a disinfectant which contains a first polyhexamethylene guanidine hydrochloride component, a second alkyldimethylbenzylammonium chloride component and water, wherein content of the components in the solution is selected in the following amounts, wt %: first component 7-34.5, second component 1.75-6.9, water - the balance.
EFFECT: disinfection of drinking water.
SUBSTANCE: group of invention relates to a synergistic antimicrobial composition which includes a zinc salt of glyphosate and 4,5-dichloro-2-n-octyl-4-isothiazolin-3-one, and is intended for controlling the level of fungi and algae. The group of inventions also provides a method of inhibiting growth or controlling growth of microorganisms in building material by adding said synergistic antimicrobial composition, a coating composition containing said synergistic antimicrobial composition and a dry film made from said coating composition.
EFFECT: use of the group of inventions increases efficiency of inhibiting growth of microorganisms, provides more precise control of the growth of microorganisms without affecting health and/or the environment.
12 cl, 7 tbl
SUBSTANCE: tableted antimicrobial composition contains polyhexamethylene guanidine hydrochloride (PHMH) in a combination with at least one ingredient specified in a group: quaternary ammonium compound (QAC), N,N-bis-(3-aminopropyl)dodecylamine and persol, as well as with an alkaline metal iodide and ammonium iodide. The antimicrobial composition has the following ratio of ingredients: PHMH - 10 to 70 wt %; QAC, N,N-bis(3-aminopropyl)dodecylamine and/or persol - 1 to 30 wt %; an alkaline metal iodide and ammonium iodide - 0.1 to 20 wt %.
EFFECT: using the invention provides the fast-acting tableted antimicrobial composition having a wide antimicrobial spectrum and a higher level of biocidal activity.
5 cl, 2 tbl, 2 ex
FIELD: veterinary sanitation.
SUBSTANCE: in the suggested disinfectant one should dissolve electrochemically activated neutral anolyte, containing 0.6 mg/ml active chlorine, with running water at 1:5 ratio and the composition of diluted electrochemically activated neutral anolyte should be supplemented with 1-1.5 mg acetic acid per 1 ml preparation. The innovation enables to decrease the concentration of active chlorine and energy expenses at keeping initial high bactericidal activity of electrochemically activated neutral anolyte and, also, apply it in aerosol form for air sanitation in poultry-breeding housings when poultry is present.
EFFECT: higher efficiency of disinfection.
FIELD: veterinary science, veterinary disinfection.
SUBSTANCE: the suggested disinfectant should be applied for sanitation of animal and poultry objects. It contains acetic acid, sodium monochloroacetate, sodium dichloroacetate, sodium acetate, sodium glycolate, sodium chloride and water at their certain ratio. At concentration of 0.3-1.0% at exposure of 3 h this preparation causes 100% lethality in sanitary-representative microorganisms.
EFFECT: higher efficiency of disinfection.
2 ex, 1 tbl
FIELD: medicine, in particular disinfectant for domestic and industrial compartments, surfaces, tools, transport.
SUBSTANCE: claimed composition contains mixture of tetramethylenediethylene tetramine with silver ninrate, stabilizer and silica gel. Tetramethylenediethylene tetramine is obtained by reaction of at 50-70°C for 60-80 min in absence of alkali, then formed solution is cooled to 18-20°C for 12-18 h.
EFFECT: disinfectant with improved quality, higher bactericide and virulicide action; method with increased yield.
2 cl, 4 tbl, 6 ex
FIELD: medicine, hygiene.
SUBSTANCE: invention relates to a disinfecting agent. Interpolymeric agent comprises the following ratio of components, wt.-%: polyguanidine base, 0.3-0.5; chlorine-containing polymer, 3.1-4.0; ethyl alcohol, 7-10; nefras, the balance. Polyalkylene guanidine base or polyoxyalkylene guanidine, or polyalkylene biguanide is used as a polyguanidine base. Mixture of chlorosulfonated polyethylene with chlorinated polyvinyl chloride taken in the ratio = (7.3-10.1):1 is used as a chlorine-containing polymer. Agent can be used for preventive prolonged disinfection in compartment with many people amount, for example, in medicine institutions, in objects of criminal-executive system, evacuation points, in apartments for culture-domestic aims, in homes, veterinary, food branch, trade, transport. Invention provides enhancing strengthening indices of polymeric cover and to expand field of its applying.
EFFECT: valuable properties of agent.
4 cl, 6 tbl, 14 ex
FIELD: chemical technology.
SUBSTANCE: invention relates to a method for preparing disinfecting agent as derivative of polyhexamethylene guanidine. Method involves thermal polycondensation reaction of hexamethylenediamine and guanidine hydrochloride for two stages. At the first stage hexamethylenediamine is added to guanidine hydrochloride melt up to the molar ratio = 1:1 and mixture is subjected for control thermostatically up to ceasing ammonia evolving. At the second stage hexamethylenediamine excess is added to formed melt of polyhexamethylene guanidine chloride that is taken as measured its molar ratio with guanidine hydrochloride = 2:n wherein n means degree of polymerization that is calculated based on molecular mass of terminal groups of polyhexamethylene guanidine derivative obtained at the first stage by the following formula: n = [%Cl]*Mk/(35.45-[%Cl]*177.678) wherein %Cl means the relative content of chlorine by mass in derivative of polyhexamethylene guanidine; Mk means molecular mass of terminal groups of polyhexamethylene guanidine derivative and at Mk = 17.034 the relative content of Cl is determined in reaction mixture before addition of hexamethylenediamine excess, and at Mk = 215.382 the relative content of Cl is calculated in the composite of polyhexamethylene guanidine derivative formed at the second stage. Then the reaction mixture is subjected for control thermostatically at temperature 165-200°C up to ceasing ammonia evolving. The end product is prepared as polymer-analog of polyhexamethylene guanidine chloride. Invention provides reducing yield of the end product in water-insoluble fraction and to enhance bactericidal activity of disinfecting agent. Invention can be used in medicine and veterinary science, in treatment of natural and sewage waters, in processes for leather and fur tanning and in industrial and domestic conditions wherein bactericidal preparations are required.
EFFECT: improved preparing method.
1 tbl, 2 ex
SUBSTANCE: invention relates to a disinfecting agent involving ethyl alcohol and an active additive that comprises additionally acetaldehyde, diethyl phthalate and glycerol and/or propylene glycol in the following ratio of components, wt.-%: ethyl alcohol, 69-94; active additive as measured for the main substance 0.0004-0.12; acetaldehyde, 0.5-1.0; diethyl phthalate, 0.08-0.20; glycerol, 0.00-0.15, and/or propylene glycol, 0.00-0.0001, and water, the balance. The disinfecting agent comprises catamine AB or biopag D as an active additive as measure for the main substance in the amount 0.025-0.12, or benzyl benzoate (3-5 mg/l) and menthol (1-3 mg/l). The disinfecting agent can be used as a cutaneous antiseptic agent (in the presence of glycerol and/or propylene glycol as components) and disinfecting agent for treatment of surfaces. Invention provides the effective treatment of surfaces in infectious of bacterial, viral and fungal etiology. Agent doesn't irritate hand skin.
EFFECT: improved and valuable properties of agent.
FIELD: animal science.
SUBSTANCE: the present innovation deals with sanitary-hygienic preparation of exercising area, equipment and animals before sampling the sperm in breeding animals. One should clean the floor in exercising area with catholyte at pH being not less than 11.0 and redox potential - not less than -600 mV; air and floor in exercising area, special equipment for animals as service ramps, artificial vaginas and sperm-collecting reservoirs should be disinfected with anolyte at pH being not more than 2.5, redox potential - not less than 1100 mV and active chlorine content of not less than 0.03%; one should wash animals skin, scrotum and prepuce with anolyte at pH being 7.0±0.5 and redox potential of not less than 900 mV. Moreover, one should treat the air in exercising area with anolytic aerosol at liquid drops diameter being not more than 50 mcm at exposure of not less than 30 min, as for artificial vaginas and sperm-collecting reservoirs they should be kept in anolyte for 30-60 min. The innovation provides to obtain high-quality sperm in farm animals.
EFFECT: higher quality of disinfection.
FIELD: medicine, ophthalmology.
SUBSTANCE: invention proposes a composition for treatment and storage of soft contact lens that comprises cetyl pyridinium chloride, polyethylene oxide of molecular mass 400 Da, ethylenediaminetetraacetic acid disodium salt, sodium hydrogen phosphate dodecahydrate, sodium dihydrogen phosphate dihydrate and water taken in the definite ratios by wt.-%. Invention provides reducing toxicity and enhances disinfecting and clearing properties of composition used for treatment and storage of soft contact lens.
EFFECT: improved and valuable properties of composition.
2 tbl, 3 ex
SUBSTANCE: the suggested preparation contains the following components: o-phthalic aldehyde, non-ionogenic surface-active substance, benzotriasol and water (in weight%). As non-ionogenic surface- active substance one should apply either neonol or syntanol. To prepare this preparation one should, first, mix o-phthalic aldehyde with non-ionogenic surface-active substance and benzotriasol, the mixture obtained should be dissolved in water. The innovation could be applied for sterilization of medicinal products.
EFFECT: higher efficiency.
4 cl, 4 ex
FIELD: veterinary science.
SUBSTANCE: the suggested composition contains a certain salt of calcium hypochlorite as an oxidizing agent and, additionally, zeolite as an adsorbent at the following ratio of components, weight%: a certain salt of calcium hypochlorite 30.0-70.0, zeolite - the rest. Application of the composition suggested provides neutralization of animal skin under any environmental conditions, both at plus and minus environmental temperature values.
EFFECT: higher efficiency of application.
6 ex, 1 tbl