Method of treating diabetic microangiopathy by mineral water "obukhovskaya"
SUBSTANCE: patients with diabetic microangiopathy are subjected to an examination which includes: general blood test, blood sugar, general urine analysis, ultrasonic examination of kidneys with the determination of indices of the kidney blood flow (Vmax, Vmin, S/D, PI, RI), basic ophthalmological parameters (vision acuity, examination of eye fundus vessels). Then, the intake of mildly-mineralised hydrocarbonate-chloride-sodium mineral water "Obyhovskaya" directly from the spring under sanatorium conditions is administered. Water is taken in heated to a temperature of 37°C in a dose of 3 ml per 1 kg of body weight 3 times per day 40 minutes before meal, the course constitutes 18 days.
EFFECT: application of the invention makes it possible to normalise the general blood test, blood sugar, general urine analysis, improve the condition of the visual analyser and indices of the kidney blood flow.
The invention relates to medicine, namely to physiotherapy (balneology), ophthalmology, urology, and is intended for the treatment of diabetic microangiopathy.
A method of treating various diseases drinking mineral water in patients (Patent for invention of the Russian Federation No. 2076713) and can be used in the treatment of gastritis with low, high secretory function, chronic colitis, cholecystitis, diseases of the operated stomach, gastric ulcer and 12 duodenal ulcer, pancreatitis, chronic hepatitis, pyelonephritis, chronic adnexitis, prostatitis without exacerbation, as well as diseases of the Central nervous system (CNS), hypertension, coronary heart disease (CHD), pulmonary tuberculosis without exacerbation, metabolic disease (diabetes, oxaluria, obesity). Patients is a natural mineral bischofite, diluted in distilled water in various proportions(1:38 600; 1:38 - 58; 1:59 - 230; 1:231 - 460; 1:461 - 600). The disadvantage of this method is the need of laboratory manipulations with the applicable agent (cultures of bischofite in various concentrations), the presence of data on the effects of the proposed method of treatment (diuretic, choleretic and decontaminant) in the absence of information about the pathological effect on the underlying disease.>
A method of preventing the progression of impaired glucose tolerance with mineral water Essentuki type (Patent for invention of the Russian Federation No. 2162697), which consists in the fact that the mineral water Essentuki # 4 take in a dose of 200 ml for 15-20 minutes before meals for 30 days. The method allows to normalize the glycemic curve, increase the early phase of insulin secretion, improve lipid metabolism. This increases the efficiency of prevention of the disease. Despite the effectiveness of the method is highly specialized preventive orientation and does not characterize the impact on vascular changes in patients with diabetes mellitus.
The known method of prevention and treatment of mineral water (Patent for invention of the Russian Federation No. 2235547), namely that as a treatment-drinking mineral water use of natural silt solution, isolated from freshwater treatment sapropel relating its characteristics to the hydrocarbonate sodium-magnesium-calcium low-mineralized water solutions. Solution obtained in the dehydration of therapeutic and enrichment of sapropel with humidity 97-93% to a moisture content of from 80 to 60% by way of gravitational hydraulic impact, with a salinity of natural silt solution is not less than 0.33 g/DM3. As the mineral and table water R�gas consumption dose recommended 100-200 ml 3-4 times a day when the course 21-28 days. As table water or mineral refreshing drink single dose recommended consumption up to 250 ml or 1.5 l up to 30 days. The disadvantage of this method is the complicated process of preparation of the dosage form, the lack of data on specific diseases and the lack of data on complex balneotherapy.
Closest to the claimed method is a method of correction of metabolic disorders in patients with diabetes mellitus (Patent for invention of the Russian Federation No. 2157692). A method for the treatment of metabolic disorders in patients with diabetes by Spa treatment, including the acceptance of ascorutin at a dose of 100 mg three times a day along with taking mineral water Essentuki # 4 of 200 ml for 20-30 minutes before meals on the background diet (table 9, 9a), glucose-lowering medications (insulin and/or sulfonylurea) according to the testimony, carbonate-mineral baths in a course of 10 treatments within 30 days. The method allows to improve carbohydrate, protein, water-salt metabolism, indicators of lipid peroxidation. Despite the good results of the known method of treatment of patients with diabetes mellitus in this method, there are no data on the dynamics of ophthalmic parameters, while the organ of vision is one of the most affected anatomical structures of the body the effects of metabolic disorders p�and diabetes. Not provided reliable data about the effect of the proposed treatment scheme, not common balneological complex of factors.
Relevant is the need to further improve methods of combined treatment of diabetic microangiopathy.
The technical result of the invention consists in the improvement of the excretory system and the organ of vision in patients suffering from microangiopathy in diabetes mellitus, contributing to the improvement of renal function and ocular parameters (visual acuity, visual field, state of the vessels of the retina).
Claimed method of correction of metabolic disorders in patients with diabetes mellitus by a combination of Spa treatments, including reception acidulous hydrocarbonate chloride-sodium mineral water, characterized in that patients with diabetic microangiopathy running tests: General blood test, blood sugar, urinalysis, conducting a study on the indicators of renal blood flow: Vmax, Vmin, S/D, PI, RI, major ophthalmic parameters: visual acuity, field of vision, the state of the vessels of the fundus, and assign ingestion of low-mineralized hydrocarbonate-chloride-sodium mineral water "Obukhov", water accept heated to a temperature of�s 37°C at the rate of 3 ml per 1 kg of body weight 3 times a day 40 minutes before meals, the course of 18 days, on the 8th and the 14th day of stay at the resort conduct control tests.
Significant differences of the claimed method are:
1) the Use of hydrocarbonate-chloride-sodium mineral water "Obukhovskaya" in the treatment of diabetic microangiopathy, providing the normalization of urinalysis tests and analyses on Nichiporenko, blood sugar.
2) Improvement of the visual analyzer: visual acuity, performance, improvement of visual fields in patients with diabetic angiopathy of the retina after treatment hydrocarbonate-chloride-sodium mineral water "Obukhovskaya" sanatorium "Obukhovskaya".
3) Improvement of renal hemodynamics: increased maximal systolic and diastolic blood flow velocity (Vmax, Vmin), and the decrease of the resistance index (RI) at the level of peripheral vessels.
The advantage of the inventive method lies in the use of mineral water "Obukhovskaya" with the following characteristics:
Organoleptic properties: odorless, without color. Transparent.
The basic chemical composition of mineral water "Obukhovskaya" describes the specified formula:
The org. to 0,010 M1,97(Na+K) more than 95 Ca 3 Mg 2
Study of the quality and composition of mineral water "Obukhovskaya" for many�them produced in years, Yekaterinburg medical research center for prophylaxis and health protection of industrial workers".
Basically ionic composition of the water is dominated by bicarbonate and chloride ions and the cations of sodium, which is typical for water Obukhov field and allows us to classify this water as hydrocarbonate-chloride-sodium. The magnitude of salinity varies from to 1,96 1,92 g/DM3that allows to consider them as low-mineralized.
Along with the basic chemical composition of the medicinal properties of mineral water "Obukhovskaya" associated with present in biologically active compounds, mainly represented by organic substances. In addition, due to the dominance in the composition of organic substances: alcohol resins, humic substances, the content of which varies from 2 to 7 mg/DM3this type of water it is possible to attribute to the mineral water with high content of organic matter humus type.
In addition to humic substances, mineral water detected the presence of neutral bitumen (oil, neutral resins, petroleum hydrocarbons) in the amount of 1.6-3.5 mg/DM3and sour bitumen (naphthenic acids, light, medium and acidic resins, acidic bitumen) to 1.0-1.4 mg/DM3. The total content of organic substances in General varies from 10.0 to 20.0 mg/DM3. Thus the highest content of organic matter is observed � water wells 10-D (With org. from 5,19 to 11,74 mg/DM3operated and used in the health-drinking purposes sanatorium "Obukhovskaya".
In terms of content of organic matter - "the org.", regulated by GOST 13273-88 "mineral drinking Water treatment and medical-table" (org. up to 10 mg/DM3).
In addition to organic substances, medicinal properties "Obukhovskaya" cause water present in relatively small concentrations, the following therapeutically active components:
- metasilicic acid - 40,9-43,2 mg/DM3;
- orthoboric acid of 26.3-26.6 mg/DM3;
- bromo - 3,94-to 4.26 mg/DM3;
- iron - 0.1 mg/DM3;
- hydrogen sulphide to 5.0 mg/DM3;
- iodine - 0,68-0,85 mg/DM3.
The study of basic physiological groups of bacteria in "Obukhovskaya" the water showed that it is dominated by nitrification, denitrifiers and butyric acid bacteria, in a somewhat smaller number are ammonifiers bacteria.
Long-term monitoring of the content in "Obukhovskaya" mineral water trace elements with concentrations in some toxic effects (cobalt, vanadium, barium, zinc, copper, arsenic, chromium, etc.) or have an adverse effect on organoleptic properties, show that their content in water wells 10-D is valid for a mine�social drinking medicinal-table water concentrations.
It follows from the above that mineral water "Obukhovskaya" from the well 10-D is used for internal admission to the sanatorium, and has favorable chemical, Toxicological, microbiological and organoleptic characteristics, but also has a pleasant taste.
As an example of treatment of diabetic microangiopathy driven scheme outpatient treatment of patient L., born in 1957, admitted to the sanatorium "Obukhovskaya" with complaints of weakness, fatigue, decreased performance, headache, dry mouth, thirst, polydipsia. With 30.01.2014 on 03.03.2014 were observed in the endocrinology center Ekaterinburg-based MAU "GKB №40" with a diagnosis of Pancreatogenic diabetes mellitus, first diagnosed. Ketoacidosis at admission. Diabetic microangiopathy: initial cataract, microangiopathy of the retina of both eyes. Diabetic nephropathy stage of microalbuminuria. CKD 1".
In September 2013, Moved the necrotizing pancreatitis on the background of alcohol abuse, underwent conservative treatment in the hospital. 30.01.2014 enters a state of ketoacidosis in urban endocrinology centre, the examination revealed diabetes. Underwent conservative treatment: Robinson WITH 28 UNITS+16 UNITS, Robinson P (Panfil) 12+12+12 ED.
The results of the survey to the treatment�: 4.03.2014 G. Blood sugar: 8:00-9:00 - 8.1 mmol/l, 11:00 - 10.8 mmol/l urinalysis: Specific gravity 1007, protein - 0.4 g/l, glucose 0.5 g/l, PL epithelium - 6-8 in p/Zr, leukocytes in 5-10 p/Zr.
Indicators of renal blood flow:
Vmax - 23,8 cm/h
Vmin - 6,91 cm/h
S/D - 3,44
PI - 1,22
RI - 0,71
Further examination by ophthalmologist:
Refractometry OD s is 0.25. Cyl - 0,25, ax 88
OS s is 0.5. Cyl - 0,5, ax 88
TVHD OD=19, TGD OD=21
VOD=0.9 n/a, VOS=0.85 n/a
04.03.2014 When taken to Sanatorium "Obukhovskaya" complaints of weakness, fatigue, decreased performance, headache, dry mouth, a veil before the eyes.
Objective data: the condition is satisfactory. Consciousness is clear. Skin normal physiological staining. There is no swelling. Tongue moist, coated with white bloom. The abdomen was soft, clubbritney in the epigastric region. The kidneys are not palpable, the low positive symptom Pasternatskogo right, to the left negative. There is a weakening of the pulsation of the arteries of the lower extremities. Height - 178 cm, weight - 69 kg, the body temperature is 36.5 ° C, BP is 135/85 mm Hg.PT.
In the sanatorium the patient L had an appointment inside of low-mineralized mineral water with high content of organic matter: hydrocarbonate-chloride-sodium mineral water "Obukhovskaya". The water took preheated to a temperature of 37°C from RAS�ETA 3 ml per 1 kg of body weight 3 times a day 40 minutes before meals, the course of 18 days. In addition, receive a diet food table # 9 + additional meals, physical therapy, massage on the collar area No. 10 in a day, vikhreva bath on the upper and lower extremities No. 10 in a day, magnetic therapy to the lower extremities No. 10 in a day.
Control examination was conducted on 8th and 14th day of stay at the resort.
8 days of treatment. The indicators of the General analysis of urine and analysis by Nichiporenko within normal limits. Blood sugar: 8:00-9:00 - 7,4 mmol/l, 11:00 - 9,2 mmol/L.
Ophthalmologist consultation: Refractometry OD s is 0.25. Cyl - 0,25, ax 88
OS s is 0.5. Cyl - 0,5, ax 88
TVHD OD=18, TGD OD=20
VOD=0.9 n/a, VOS=0.85 n/a
14-e the day of treatment. The indicators of the General analysis of urine and analysis by Nichiporenko within normal limits. Blood sugar: 8:00-9:00 and 5.86 mmol/l, 11:00 - 8,28 mg/L. ophthalmologist Consultation: Refractometry OD s is 0.25. Cyl - 0,25, ax 88
OS s is 0.5. Cyl - 0,5, ax 88
TVHD OD=18, TGD OD=20
Indicators of renal blood flow:
Vmax - 26.7 cm/h
Vmin - 8.1 cm/sec
S/D - 3,29
PI - 1,21
RI - 0.69
Method of correction of metabolic disorders in patients with diabetes mellitus by a combination of Spa treatments, including reception acidulous hydrocarbonate chloride-sodium mineral water, characterized in that patients with diabetic microangiopathy running tests: General blood test, blood sugar, urinalysis, conducting� study indicators of renal blood flow: a Vmax, Vmin, S/D, PI, RI, major ophthalmic parameters: visual acuity, field of vision, the state of the vessels of the fundus, and assign ingestion of low-mineralized hydrocarbonate-chloride-sodium mineral water "Obukhov", take water heated to a temperature of 37°C at the rate of 3 ml per 1 kg of body weight 3 times a day 40 minutes before meals, course 18 days, on the 8th and the 14th day of stay at the resort conduct control tests.
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention relates to 2-pyridone compounds, represented by general formula , , where A represents benzene ring or pyridine ring, X represents structure, represented by general formula , V represents single bond or lower alkylene, W represents single bond, ether bond or lower alkylene, which can include ether bond, or their tautomers or stereoisomers.
EFFECT: obtaining pharmaceutically acceptable salts, which possess excellent activating activity with respect to GK and can be applied as medications.
27 cl, 23 tbl, 371 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to quinolines substituted by phosphorus-containing group of formula and applicable in medicine, wherein Z represents V1 and V2 are independently specified in hydrogen or halogen; one of R and R` represent phosphorus-containing substitute Q; the other one is specified in hydrogen or methoxyl; wherein the phosphorus-containing substitute Q represents A represents O; L represents C1-6alkyl; J represents NH or C3-6heterocycloalkyl and J is optionally substituted by G3; X is absent or represents -C(=O)-; X is absent or represents C1-6alkyl; each of R1 and R2 are independently specified in C1-6alkyl or C1-6alkoxy; G3 represents C1-6alkyl, R3S(=O)m-, R5C(=O)- or R3R4NC(=O)-; R3, R4 and R5 are independently specified in 3 or C1-6alkyl; m is equal to 0-2.
EFFECT: there are presented new protein kinase inhibitors effective for treating the diseases associated with abnormal protein kinase activity.
20 cl, 42 ex, 8 tbl, 3 dwg
SUBSTANCE: invention relates to medicine, namely to endocrinology, and deals with stimulation of insulin secretion. For this purpose 2 ml of concentrated nitro-glycerine solution are diluted with distilled water, cotton swab is soaked with obtained solution, stretched to 10-12 cm long and 3-4 cm wide size, applied perpendicular to spine on the left at the level of Th12, covered with cellophane and sealed with self-adhering plaster, with patient being turned onto back with preservation of said position for 1 hour.
EFFECT: method provides enhancement of insulin secretion by pancreas due to improvement of its blood supply.
2 ex, 2 tbl, 4 dwg
FIELD: medicine, pharmaceutics.
SUBSTANCE: present invention refers to new substituted aminotetrahydropyranes of structural formula or to their pharmaceutically acceptable salts , and , wherein V is specified in groups having the formulas below, Ar represents phenyl unsubstituted or substituted by one to five halogen atoms, each of R1 and R2 is independently specified in C1-C6alkyl; R3 is specified in a group consisting of C1-C6alkyl; cyano; tetrazolyl; -C(O)OC1-C6alkyl and -C(O)NH2; wherein C1-C6alkyl is substituted by 1-4 substitutes independently specified in a group consisting of OH; -C(O)NH2 and -CO2H. The declared compounds can be dipeptidylpeptidase-IV inhibitors and can be applicable in treating or preventing diseases involving the enzyme dipeptidylpeptidase-IV, such as diabetes, and especially type 2 diabetes mellitus.
EFFECT: invention also refers to a pharmaceutical composition containing the above compounds, and using the above compounds and compositions for preventing or treating the diseases involving the enzyme dipeptidylpeptidase-IV.
12 cl, 14 ex
SUBSTANCE: invention relates to the field of organic chemistry, namely to derivatives of diaza-spiro[4.5]decan-1-one of formula (I) or to their pharmaceutically acceptable salts, where. R1 is a substituted phenyl, which contains one substituent, selected from the group, including C1-4-alkyl, C3-6-cycloalkyl halo-C1-4-alkyl and halo -C1-4-alkoxy, and which can additionally contain one substituent, selected from a halogen; R2 is hydrogen, C1-4-alkyl, phenyl, substituted phenyl, with the substituted phenyl containing one substituent, selected from the group, including C1-4-alkoxy; R3 is -R4, -C(OH)R5R6 or -C(O)NR7R8; R4 is phenyl, phenyl-C1-4-alkyl, substituted phenyl, substituted phenylcarbonyl, with the substituted phenyl, substituted phenylcarbonyl containing from one to two substituents, selected from the group, including a halogen, halo-C1-4-alkyl; one of R5 and R6 is hydrogen, C1-4-alkyl, and the other is aminocarbonyl, phenyl, substituted phenyl or substituted phenyl-C1-4-alkyl, with the substituted phenyl or substituted phenyl-C1-4-alkyl containing from one to two substituents, independently selected from the group, including a halogen; one of R7 and R8 is hydrogen C1-4-alkyl, and the other is C1-4-alkyl, C3-6-cycloalkyl, C1-4-alkoxy-C1-4-alkyl, phenyl-C1-4-alkyl, substituted phenyl or substituted phenyl-C1-4-alkyl, with the substituted phenyl or substituted phenyl-C1-4-alkyl containing one substituent, selected from the group, including a halogen, halo-C1-4-alkyl; or R7 and R8 together with a nitrogen atom, which they are bound to, form pyrrolidinyl; n equals zero or 1/ The invention also relates to a pharmaceutical composition based on the compound of formula (I), application of the formula (I) compound and a method of treatment.
EFFECT: obtained are novel heterocyclic compounds, useful as an inhibitor of hormone-sensitive lipase.
17 cl, 57 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to the pharmaceutical industry and represents a formulation specially adapted for insulin transformation into the aerosol state, containing insulin in water from 100 IU/ml to 1,200 IU/ml and 2 to 4 Zn2+ ions per the insulin hexamer, wherein the formulation is preservative-free and wherein the formulation is able to transform into the aerosol state as an aerosol spray when using a holed vibration plate with no foaming of the formulation, when the formulation is kept on a back surface of the holed plate by gravity, and the spray is ejected from the front surface of the holed plate entirely by vibrating the holed plate.
EFFECT: invention provides reducing the foaming of the formulation, the time of transformation into the aerosol state and providing the more effective administration of an insulin dose.
19 cl, 5 dwg
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention relates to the pharmaceutical industry, namely to a medication for the complex therapy of patients with type 2 diabetes mellitus and a method of the complex therapy of patients with type 2 diabetes mellitus. The medication for the complex therapy of patients with type 2 diabetes mellitus contains a cleaned and dried rhizome of Curcuma longa in the form of powder with the specified size of particles. The method of the complex therapy of patients with type 2 diabetes mellitus consists of the daily intake of the cleaned and dried rhizome of Curcuma longa in the form of powder with the specified size of particles twice per day after dinner and supper at the background of the intake of pelleted hypoglycaemic agents without changing the dose and scheme of the drug therapy.
EFFECT: medication produces a direct stimulating impact on β-cells of the pancreas and ensures the development of a hypoglycaemic effect, including early stages of the disease development.
3 cl, 1 dwg, 5 tbl
SUBSTANCE: invention refers to medicine, namely to therapy and endocrinology, and can be used in treating patients suffering type 2 diabetes mellitus. That is ensured by a continuous exenatide delivery by implanting into a patient into an osmotic delivery device comprising an impermeable container, a semi-permeable membrane, an osmotic mechanism integrated into the container and adjoining the semi-permeable membrane, a piston adjoining the above osmotic mechanism; the above piston forms a movable seal with an inner surface of the container and divides the container into a first chamber comprising the osmotic mechanism, and a second chamber comprising a suspension formulation, and a diffusion adjustor. The suspension formulation contains a particle formulation containing exenatide particles having a diameter of less than 10 to 30 mcm. The delivery formulation contains a solvent specified in a group consisting of benzyl benzoate, lauryl lactate and lauryl alcohol, and polyvinylpyrrolidone polymer. The delivery formulation has a viscosity of approximately 10,000 poise to approximately 20,000 poise at 37°C. The continuous exenatide delivery in the therapeutic concentration is ensured for 5 days or less. The continuous exenatide delivery from the osmotic delivery device in a dose of exenaide of 10 mcg/day, 20 mcg/day, 30 mcg/day, 40 mcg/day, 60 mcg/day, and 80 mcg/day can be effected through at least three months.
EFFECT: method enables the effective treatment of the given pathology by the fast achievement and long maintenance of the exenatide concentration to be completed rapidly with no constant injections or oral administration.
15 cl, 20 tbl, 21 dwg, 4 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: present invention refers to a citrate of a compound described by formula (II) below, and a pharmaceutical composition containing said citrate.
EFFECT: experimental results of the present inventions prove that said citrate can inhibit activity of phosphodiesterase type 5 and can be used for treating erectile dysfunction, for inhibiting thrombocyte aggregation and treating thrombosis, for reducing pulmonary hypertension and treating cardiovascular diseases, asthma and diabetic gastroparesis.
FIELD: medicine, pharmaceutics.
SUBSTANCE: group of inventions refers to a compound of formula (I) or its pharmaceutically acceptable salts of formula (I), wherein X represents O, S; Y represents O, S; R1 independently represents H, alkyl; G1 represents ethyl; each G2 and G3 are independently specified in H, alkyl, trifluoromethyl, halogen, nitro, amido, cyano and tetrazolyl. The invention also refers to a pharmaceutical composition possessing activating action on peroxisome proliferator activated receptors subtype α, subtype δ and subtype γ and containing an effective amount of the compound of formula (I) or its pharmaceutically acceptable salts. The compounds of formula (I) are applicable for treating or producing a drug preparation for treating or preventing the diseases associated with peroxisome proliferator activated receptors subtype α, subtype δ and subtype γ. The compounds of formula (I) are produced by a reaction of the compound of formula (III) and the compound of formula (IV) when heated in acetonitrile under reflux in the presence of potassium carbonate to produce the compound of formula (II), to saponify the compound of formula (II) in alcoholic solution in the presence of alkali and to acidify the reaction mixture to produce the compound of formula (I). X, Y, R1, G1, G2 and G3 have the above values; R3 represents a leaving group specified in OH, Cl, Br, I, OTs, OMs.
EFFECT: compounds of phenylpropionic acid possessing the activating action on peroxisome proliferator activated receptors (PPARα, δ, γ).
15 cl, 2 ex
SUBSTANCE: method includes carrying out complex treatment at the background of diet therapy. Intake of antihelmintic of vegetable origin and immunomodulator is carried out daily with washing down each of them with 200 ml of radon water. Intestinal lavage is performed every second day. On days of performing intestinal lavage, patient takes bath with radon water in the morning before lavage, with performing underwater hydrodynamic massage (UHM) on other days. On days, when intestinal lavage is not performed, sessions of sound therapy are carried out after UHM.
EFFECT: method provides correction of biological age of organism as prevention of premature ageing.
3 cl, 4 tbl, 2 ex
SUBSTANCE: conducting No. 5 dietary therapy and doing therapeutic exercises are prescribed. That is combined with taking low-mineralised carbonated sodium calcium chloride hydrogen carbonate sulphate mineral water "Essentuki Novaya" at 3.5 ml per 1 kg of patient's body weight 30-40 minutes before meals; 2% pentoxiphyline full-length ampli-pulse-phoresis procedures are performed daily with an anode placed on a projection of liver, whereas a cathode is placed symmetrically on back in the III and II operation modes (6 minutes each), at modulation frequency 150 Hz, modulation depth 75%; the therapeutic course includes 10 procedures.
EFFECT: method enables reducing the length of treatment and increasing the clinical effectiveness.
5 tbl, 2 ex
SUBSTANCE: method involves taking general baths and prescribing mud applications on lower extremities with underlying standard drug therapy. The patient takes prepared silicate-carbonate baths with the concentration of sodium salt of metasilicic acid of 100-150 mg/l and the content of carbon dioxide of 1.2 g/l. The bath water temperature is 36°-37°C. The length of the procedure is 10-15 minutes. Taking the baths is followed by having a 30-40-minute rest. Sulphide silt mud sock- or boot-like applications are performed. The mud temperature is 32°-36°C; the length of procedure is 8-20 minutes. The procedures are performed 2 days running, with a pause on the 3rd day. The therapeutic course makes 6-10 procedures.
EFFECT: method provides the further development of the symptom-free involvement of target organs: heart, kidneys, vessels by taking the antihypertensive, antianginal and antiarrhythmic effects, promotes the energetic and adaptation possibilities of the body.
SUBSTANCE: halogen-containing hydrocarbonate chloride sodium, alkaline, boron high-magnesium, iodine and fluorine natural mineral water 'Lazarevskaya Tselebnaya' No. 11-M of the Volokonskoye deposit in Sochi is taken according to the following procedure: first course involves administering the water 20-25 minutes before meals in small sips 6 times a day in an amount of 180-200 ml at temperature 23-24°C for 30 days daily with a pause of 1-2 days and repeating the course of administration of the same mineral water 15-20 minutes before meals in small sips 8 times a day in an amount of 150-170 ml at temperature 23-24°C for 30-35 days.
EFFECT: method enables providing higher sportsman's performance by normalising the vegetative nervous system, carbohydrate metabolism values and recovered activity of antioxidant enzymes in erythrocytes.
3 cl, 5 tbl, 2 ex
SUBSTANCE: method involves administration of low-mineralised chloride-hydrocarbonate sodium, alkaline, boron high-magnesium, -iodine, -fluorine natural mineral water 'Lazarevskaya Tselebnaya' No.11-M of the Soloniki deposit and No. 84-M of the Volkonskoye deposit in Sochi. Mineral water is administered 17-19 minutes before meals in a dose of 170-190 ml in gulps at 23-24°C. The water is administered daily, six times a day for at least 24-30 days. The course of water administration is repeated every three months for three years.
EFFECT: method provides higher clinical effectiveness ensured by improving the metabolic processes in the brain.
2 cl, 7 tbl
SUBSTANCE: halogenated hydrocarbonate chloride sodium, alkaline, boron, high-magnesium, iodine and fluorine natural mineral water 'Lazarevskaya Tselebnaya' No. 84-E of the Volkonskoye deposit in Sochi is taken according to the following procedure: 18-20 minutes before meals in small sips, 6 times a day daily in a dose of 180-200 ml at t=24-25°C for 40 days every 3-5 days with taking the above natural halogenated mineral water in the same amounts for the following 45 days. The therapeutic course makes 3 years and repeats every 3 months.
EFFECT: method enables reducing metabolic disorders by a systemic insulin-producing effect in a combination with a hypolipidemic and diuretic component.
3 cl, 4 tbl, 2 ex
SUBSTANCE: according to one version, the method involves studying the heart rate variability and a motion state, dietary nutrition, baths with mineral water, mineral water intake, physiotherapeutic procedures. The dietary regimen is specified taking into account the measured immunoglobulin IgG values to detect food intolerance and elimination thereof from the nutrition. Low-salt sulphate calcium-magnesium-sodium mineral water is taken. The baths are taken with mineral water from a water-bearing formation of Middle Devonian at a depth of 1100-1278 m by using mineral water representing a salt brine of Devonian Sea M 240-260 g/dm3 of sodium-chloride composition Cl>95, Na++K+>80 mg-eq.%, with an acid reaction of the medium, at pH 4.7-5.5. According to the other version, the method additionally contains massage sessions and acupuncture taking into account the patient's heart rate variability.
EFFECT: group of inventions provides more effective health improvement by taking into account individual food intolerance and the patient's autonomic nervous system features.
2 cl, 3 ex
SUBSTANCE: invention relates to a method of obtaining mineral silicic water (MSW), intended for application for medical purposes. The method of obtaining includes hydrolysis of tetraethoxysilane in the TEOS mixture: ethanol: water, acidified by HCl. Nanosol is obtained at a temperature of 55-65°C for 1.5 hours with evaporation of ethanol to the volume reduction by 1/3, then, dilution of the obtained nanosol with a physiological solution NaCl is carried out in 2 steps with equal portions of the physiological solution, preliminarily heated to 40-50 in a ratio of volumes of the initial nanosol: physiological solution 1:7 with 15-minute interval. After each dilution a temperature of the solution is kept in the range of 55-65°C.
EFFECT: increase of the compound application efficiency.
SUBSTANCE: halogen-containing hydrocarbonate chloride sodium, alkaline, boron high-magnesium, iodine and fluorine natural mineral water 'Lazarevskaya Tselebnaya' No. 84-E of the Volokonskoye deposite in Sochi is taken according to the following procedure: 30-35 minutes before meals in small sips, six times a day daily in a dose of 200-250 ml at t°=(23-24)°C, for 45 days every 2-3 days with taking the above natural halogen-containing mineral water in the same volumes for the following 45 days. The therapeutic course makes 3 years.
EFFECT: method enables improving the health status in the individuals subject to the hazardous effect of radionuclides taken with water or food.
2 cl, 6 tbl, 3 ex
SUBSTANCE: invention relates to medicine, namely to a method of preventing complications of rhinitis or an influenza-like syndrome. The method of preventing complications of rhinitis or the influenza-like syndrome consists in the following: an isoosmotic ionic sea water-based solution with osmolarity, equal to 250-350 mOsm/kg, is introduced daily into each nostril of patients suffering from rhinitis or the influenza-like syndrome, and at the remission stage in the certain regimens.
EFFECT: increased method efficiency.
9 cl, 13 dwg, 13 tbl, 1 ex
FIELD: medicinal microbiology, medicine, pharmacy.
SUBSTANCE: invention relates to agents used for enhancing sensitivity of microorganisms to antibacterial preparations. Invention involves applying hydrocarbonate chloride-sodium drinking mineral water "Obukhovskaya" with the total mineralization 1.8-2.2 g/l as an agent for enhancing sensitivity of microorganisms to antibacterial preparations that is used early for treatment of atopic dermatitis and as an agent for treatment of iodine-deficient states. It has been found by method using disks that mineral water "Obukhovskaya" provides enhancing sensitivity of microorganisms to such antibacterial preparations as antibiotics and specific preparations against yeast-like fungi.
EFFECT: improved and valuable agent.
6 tbl, 6 ex