Method of treating chronic abacterial prostatitis complicated by sexual dysfunction
SUBSTANCE: combined phyto- and physiotherapy is conducted. The phytotherapy involves administering Prolit Super 2 capsules two times a day (at 8 and 14 o'clock) for one month; the physiotherapy provides rectal electrical stimulation by means of AndroGyn for 8 minutes a day, 15 procedures in the therapeutic course.
EFFECT: invention enables improving the sexual function and prostatic microcirculation, and can be used in ambulance situation.
1 dwg, 1 ex
The invention relates to medicine, namely to urology.
Sexual problems along with pain of different localization and dysuric phenomena represent the most common triad in chronic prostatitis symptoms, sexual dysfunction is a complication of chronic prostatitis .
Sexual dysfunction in CP patients are very diverse even in the same patient at different periods of the disease. The variability is dependent upon the activity of the inflammatory process, the degree of involvement of adjacent organs, the condition of the nervous and endocrine systems, patient age, comorbidities. However, most researchers speak about the oppression of libido, disorder adequate erections and accelerated ejaculation .
One of the most common types of sexual dysfunction in chronic prostatitis is premature ejaculation (PE) . Of 420 patients with CP in 35% of the identified PE, and half of them with ureteroscopy revealed a characteristic pattern colliculitis .
In chronic inflammation of the prostate gland, posterior urethra and seminal tubercle is broken the sensitivity of peripheral nerve endings, which leads by reflex excitability changes corresponding spinal centres. Thus, PE occur in�schaya, as a result of urological diseases, is closely connected with the spinal PE, only in the first case of spinal sexual centers involved in the process again by reflex.
Of 638 patients with chronic infectious and non-infectious prostatitis in age from 19 to 60 years (average 36,1±11,9 years) sexual dysfunction was present in 216 people(33,9%) .
The known method of normalization of neurophysiological parameters of sexual intercourse  by the appointment of herbal remedies Prostanorm and Phyto Novo-ETS patients with chronic abacterial prostatitis, also celebrating the premature ejaculation. All patients underwent the same type of treatment in four weeks: at 8:00 and 14:00-0,5 teaspoon of the extract of prostanorm in water or on sugar for 30-40 minutes before meals; 20:00 - 0,5 teaspoon of the Herbal extract Novo-Seda, dissolved in a little water, after 1-1,5 hours after dinner. Was the efficiency of the known method against premature ejaculation, but positive dynamics from the actual inflammatory process in the prostate gland were noted.
A method of treating premature ejaculation (EN 2400249 C1) consists in the fact that medical treatment is carried out tentena 1 tablet 2-3 times a day for 8-10 weeks, and additionally perform laser those�the Apia by exposure to continuous crotch (IR) radiation of 10 mW daily for 10 min, the course is 10-12 procedures. However, the known method only applies to one type of sexual dysfunction - speed ejaculation without affecting other elements of the copulative act.
Known methods aimed at correcting the neuro-physiological component of the sexual act, do not affect the pathogenetic mechanisms of chronic prostatitis, and thus do not eliminate the cause sexual dysfunction.
In the present method, using combined herbal preparation Prolit Super capsule that contains in each capsule (600 mg) leaf extracts of shelkovchanka curly (Strobilanthi Folium) 80 mg, leaves kidney tea (Orthosiphonis Folium) - 6 mg, ginseng roots present (Radix Ginseng) - 5 mg, seahorse (Sea Horse) - 5 mg, rhizomes of Imperata cylindrica (Rhizoma Imperatae), 2 mg, roots of licorice (Glycyrrhizae Radix) - 2 mg. According to the instructions super shed used as a diuretic, in inflammatory diseases of the bladder and urethra, chronic hepatitis, renal and cardiac edema. However, some components of the shed are also super adaptogenic, immunomodulatory, protivovospalitelnoe action and stimulate the contraction of muscle fibers of the prostate, improving hemodynamics, microcirculation and facilitates the emptying from profilactica, thus, congestio.The method is as follows. After examination of the patient and confirmation of the diagnosis "chronic abacterial prostatitis, complicated sexual dysfunction", the patient is prescribed Prolit Super 2 capsules per day (at 8 and 14 hours) during the month; at the same time carry out physical therapy by rectal stimulation with the help of the Androgyne in for 8 minutes every other day, 15 procedures for the course. In the process of electrical stimulation results in an additional improvement of microcirculation and tone the prostate gland, which potentiates the effect of super shed.
Example. Patient A., 43 years. Chronic abacterial prostatitis for 7 years, had received repeated courses of treatment (massage, physical therapy, alpha blockers, vitamins, antioxidants), but every year at least two times marked aggravation that followed every time more severe sexual dysfunction. The leading complaints at the time of treatment were: constant pain in the perineum, painful ejaculation, decreased libido, difficult ejaculation. It was also revealed impaired microcirculation.
The patient was treated with chronic abacterial prostatitis, complicated sexual dysfunction combination of phyto - and fitoterapia: capsule Super Shed 2 capsules twice daily (at 8 and 14 hours) within t�e of the month and rectal electrical stimulation by using the apparatus of the Androgyne within 8 minutes through day 15 of procedures for the course.
After 2 weeks the patient noted improvement in many parameters, however, remained moderate violation of microcirculation, difficult ejaculation, weak pain during ejaculation. One month later the patient had no complaints, laser Doppler was an improvement of microcirculation by 84%, sexual function has fully recovered.
The method was tested in urogenital clinic research center of Novosibirsk research Institute of tuberculosis in 9 patients aged from 38 to 49 years with chronic abacterial prostatitis, complicated sexual dysfunction, within an average of 5, 7 years. Patients identified the following types of sexual dysfunction: decreased libido (all 9), premature ejaculation (2), obstruction ejaculation (5), decrease the brightness of orgasm (8), painful ejaculation (3). Also in all patients by laser Doppler set marked impairment of microcirculation in the prostate gland.
All patients received treatment according to the claimed method with good tolerability and efficacy, the comparison of the parameters presented in the following chart, which demonstrates the high efficiency of the proposed method has improved the sexual function �about all the criteria including leveled main pathogenetic mechanism of chronic abacterial prostatitis is a violation of the microcirculation in the lesion (see chart).
Thus, the claimed method of treatment of chronic abacterial prostatitis, complicated sexual dysfunction combination of phyto - and fitoterapia, characterized in that the herbal capsules carry out Super Shed 2 capsules twice daily (at 8 and 14 hours) during the month, and physiotherapy is carried out by rectal stimulation with the help of the Androgyne in for 8 minutes every other day, 15 procedures for the course, is a highly effective, well tolerated, and can be used in outpatient practice.
1. Culcavey E. V. Prostatitis. Diagnosis and treatment: manual / E. V. Culcavey, A. I. Neimark. - M.: GEOTAR-Media, 2010. - 256 with: ill. (Library specialist).
2. Tkachuk V. N., Gorbachev A. G., Golanski L. I. Chronic prostatitis. - L.: Medicine, 1989.
3. Culcavey E. V. Our opinion on the violation of ejaculation in men in some regions of Russia /E. V. Culcavey, P. A. Azizov, M. D. Romanovsky et al. / / Urology. - 2010. - No. 3. Pp. 49-52.
4. Loran O. B., Pushkar D. Yu., Segal A. S., etc. Our understanding of chronic prostatitis // Farmateka. - 2002. - No. 10. Pp. 69-75.
A method for the treatment of chronic abacterial prostatitis, complicated�CSOs sexual dysfunction combination of phyto - and physiotherapy, characterized in that the herbal capsules carry out Super Shed 2 capsules twice daily (at 8 and 14 hours) during the month, and physiotherapy is carried out by rectal stimulation with the help of the Androgyne in for 8 minutes every other day, 15 procedures for the course.
SUBSTANCE: invention relates to a method of treating a mammal with endometriosis. The claimed method includes the pulse or interrupted peroral introduction of an N-acetyl-L-cysteine-containing pharmaceutical composition for 3-5 successive days with the following 2-4-day break or for 1-3 successive days with the following 1-2-day break, for at least a two-month time period. N-acetyl-L-cysteine in the said method is introduced in a dose, constituting from 20 to 90 mg/kg/day.
EFFECT: claimed method provides the more significant effect with respect to endometriosis symptoms in comparison with the traditional daily introduction of N-acetyl-L-cycteine.
11 cl, 7 dwg, 2 tbl, 3 ex
FIELD: veterinary medicine.
SUBSTANCE: method comprises intramuscular administration in the body of the medicinal drug of antioxidant action prior to anticipated calving twice. The first administration is performed 50÷60 days before. The second administration is carried out 15÷20 days prior to anticipated calving. The medicinal drug is used as immunofan which is administered in a dose of 4÷5 ml per animal.
EFFECT: invention is highly effective for prevention of postpartum inflammatory diseases of uterus and mammary gland.
3 tbl, 1 ex
FIELD: veterinary medicine.
SUBSTANCE: method comprises intramuscular administration of the tylosin-containing preparation at a dose of 0.05 ml/kg body weight once a day for 3-4 days in all forms of mastitis. The tylosin-containing preparation is used as the preparation of the following composition, wt %: colistin sulphate - 4.0-6.0; tylosin base - 4.0-6.0; benzyl alcohol - 4.0; water for injection - 15.0; 1,2-propylene glycol - 100.0%.
EFFECT: use of the claimed invention enables to improve the therapeutic efficacy of treatment of mastitis.
3 tbl, 3 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: group of inventions refers to medicine and concerns a stable composition of nanostructured Sildenafil inhibiting cyclic guanosine monophosphate (cGMP) specific phosphodiesterase type 5 (PDEV) containing a nanostructured Sildenafil base or its pharmaceutically acceptable salts having an average particle size of less than approximately 500nm, a stabilising agent, wherein the composition is prepared in a microfluidics-based continuous-flow tank reactor, and the composition possesses a semi-amorphous structure. The group of inventions also concerns a method for preparing the composition of nanostructured Sildenafil; using the above composition for preparing the pharmaceutical composition for treating male or female sexual dysfunction and pulmonary arterial hypertension.
EFFECT: group of inventions provides the improved solubility of the composition.
8 cl, 11 ex, 14 dwg
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to compounds of structural formula (I), which can be used for treating diseases mediated by an androgen receptor. In formula (I), R1 means (C2-6)alkyl, (C1-6)alkyloxy, -S(O)m-(C1-6)alkyl, (C1-6)fluoroalkyl, CN or halogen, R2 and R3 are identical or different and mean a hydrogen atom or (C1-9)alkyl, R4, R5, R6, R7 are identical or different and mean a hydrogen or halogen, X means CH or N, Y means either a nitrogen atom, or a carbon atom substituted by (C1-6)alkyl, (C1-6)alkyloxy, (C1-6)fluoroalkyl, a hydrogen atom or halogen; m is equal to 0, 1 or 2.
EFFECT: invention refers to using the compounds for preparing a therapeutic agent for preventing and/or treating hirsutism, androgenetic alopecia, hypertrichosis, atopic dermatitis, disordered sebaceous gland, such as hyperseborrhea, acne, greasy skin or seborrheic dermatitis.
8 cl, 2 tbl, 26 ex
FIELD: veterinary medicine.
SUBSTANCE: method comprises intravaginal administration of probiotic preparation "Giprolam" (Lactobacillus fermentum 44/1 and Lactococcus lactis subsp. Lactis 574). "Giprolam" is administered for 5-7 days prior to calving daily at a dose of 100 cm3.
EFFECT: use of the claimed invention promotes to maintain the amount of lactobacilli and bifidobacteria at the physiological level, prevents the colonisation of the genital tract with potentially pathogenic microflora and prevents the occurrence of postpartum infections.
6 tbl, 2 ex
FIELD: veterinary medicine.
SUBSTANCE: method comprises the combined use of the tissue preparation on the 1, 3 and 5 days of treatment, and 15% solution of ASD-2f on tetrahydrovit at a dose of 10 ml intramuscularly on the 2, 4 and 6 days of treatment. The tissue preparation is used as biogenic stimulator aminoseleton which is administered subcutaneously into the upper third of the neck in increasing dose of 40-45-50 ml.
EFFECT: method is highly effective for treatment of subclinical mastitis in lactating cows.
3 tbl, 1 ex
FIELD: veterinary medicine.
SUBSTANCE: chemotherapeutic agent is used as N,N-dimethylamino-propylamides of fatty acids of the formula 1 which are used in the form of salts with pharmacologically acceptable acids.
EFFECT: use of the claimed invention is highly effective for treatment of animals with postpartum endometritis.
4 tbl, 2 ex
FIELD: veterinary medicine.
SUBSTANCE: method comprises the use of chemotherapeutic agents. The chemotherapeutic agent is used as N,N-dimethylamino-propylamides of fatty acids of the formula 1 which are used in the form of salts with pharmacologically acceptable acids.
EFFECT: use of the claimed invention is highly effective for treatment of endometritis in animals.
4 tbl, 2 ex
SUBSTANCE: group of inventions refers to medicine and medical equipment, namely to obstetrics and gynaecology, and can be used for the local treatment of inflammatory diseases of the uterine cavity. The method is implemented by inserting a waveguide of a presented device in a protection enclosure into the uterine cavity. A taper base of a narrow portion of the enclosure leans on an external orifice of the cervical uterus to prevent accidental perforation of the uterus. An infusion system regulator is used to set the spray supply of a therapeutic solution into an irrigation canal of the ultrasonic device. Thereafter ultrasonic vibrations are generated, and the uterine cavity is treated with the sounded therapeutic solution. The exposure length is 3-5 minutes at the ultrasonic vibration frequency of 25 kHz, infusion rate approximately 100-150 ml/min. The total infusion volume is not less than 300 ml. The ultrasonic treatment enables providing the continuous outflow of the uterine discharge. The device comprises an US generator, an acoustic assembly, the waveguide with the protection enclosure, the infusion system for the therapeutic solution supply. The acoustic assembly and waveguide comprises the irrigation canal. A working tip of the waveguide represents a short cylinder having a diameter greater than the rest portion. The irrigation canal of the waveguide has a diameter of 2 mm. The protection metal thin-wall enclosure has a crimped distal end and drain holes and represents two cylindrical elements of various diameters connected by a taper junction with milled grooves arranged so that to enable the fluid access to the working tip cylinder, the length of which makes no more than 3 mm.
EFFECT: inventions provide the effective cleansing of the uterine cavity from infected and necrotised tissues with improved comfort and safety of the procedure with using no endoscopic equipment, cervical dilation manipulations and uterine pre-probing.
2 cl, 3 dwg, 3 ex
SUBSTANCE: electrode device for the stimulating action containing several electrodes all of which are placed on the electrode module, and electrode modules are connected in a two-coordinate array by means of magnetic electric connectors. The magnetic electric connector consists of the contacts from magnetosoft metal placed on lateral surfaces of modules, between opposite contacts of the neighbouring modules the magnet for physical and electric connection of modules in the array is installed. Each electronic module contains power supply contacts and a series communication interface contact for communicating of the electronic modules among themselves, and one electronic module contains control and indication units. Magnets can be spherical or cylindrical.
EFFECT: invention allows to simplify the device design.
2 cl, 5 dwg
SUBSTANCE: invention refers to medicine and can be used for the correction of the individual's functional state and performance. That is ensured by administering Semax neuroactive peptide in a dose of two drops in each nasal passage. That is followed by the electric current exposure covering a frontal-mastoid region at pulse length 0.2ms, current intensity 0.8mA and pulse train 800Hz for 40 min. The exposure is combined with at least 10 sessions of hyperbaric oxygenation at pressure 1.6 atm.
EFFECT: method provides the rapid and effective increase of performance in sportsmen, military men and individuals involved in the other professions related to significant physical and mental stress by improving the functions of various regions of brain cortex as a result of the selected complex exposure enabling the substantial vasodilatation and maximum tissue oxygenation.
SUBSTANCE: invention refers to medicine, namely to psychiatrics, addictology and concerns treating addiction. That is ensured by an integrated treatment, involving administering homeopathic therapeutic agents, a reflex therapy covering biologically active points (BAPs) and a transcranial electric stimulation of the endorphine system. The homeopathic therapeutic agent is selected taking into account a body type, a temperament type, patient's personality.
EFFECT: method provides the effective treatment of a wide range of addictions by administering therapeutic agents selected taking into account the patient's characteristics combined with the reflex therapy and the transcranial electric stimulation of the endorphine system.
7 cl, 5 ex
FIELD: veterinary medicine.
SUBSTANCE: upon detection of an increased level of activity of the horse a therapeutic signal is generated to enforce at least one muscle involved in the shift of the laryngeal anatomical structure with respect to the upper airway of the horse. The therapeutic signal is given to the upper airways tissue for maintaining unobstructed airflow. At that the pacemaker is used in the form of a processor made with the ability to generate the therapeutic signal based on the said detected increased level of activity to enforce the muscle involved in the shift of laryngeal anatomical structure with respect to the upper airway of the horse.
EFFECT: invention enables to improve the efficiency of treatment which is achieved by the stimulation of the upper airway muscles synchronously with the periods of the respiratory cycles of the horse and by functioning of the stimulating system only during an increased physical activity.
20 cl, 6 dwg, 1 tbl
SUBSTANCE: endoresection of an intraocular new growth is followed by covering the scleral bed surface with a photosensitising gel (PS gel) containing 0.1% monoethylene diamine monoamide chlorine adipate e6. The PS gel exposure makes 3 minutes. The residual gel is taken off. An active portion of one needle electrode is intraocularly applied on the scleral bed in parallel with the retinotomy border at 0.5-0.7 mm. The second electrode is applied in parallel to the first one at 3-4 mm to the centre of the scleral bed. That is followed by performing an electrochemical lysis (ECL) at the current intensity of 5 mA for 10 seconds. The electrodes are gradually moved along the scleral bed surface first circle-wise, in parallel to the retinotomy border, then from the periphery to the centre. The ECL covers the entire area of the scleral bed at the current intensity of 5 mA for 10-15 seconds in each position of the electrodes. That is followed by intraocular photodynamic therapy (PDT) along the entire area of the scleral bed with involving the 1.5 mm surrounding tissues. The patient is exposed to laser light at a wave length of 662 nm, power density of 60 J/cm2, by fields of 4 mm in diameter, circle-wise from the periphery to the centre, and involving the adjoining fields by 5% of the area.
EFFECT: avoiding the tumour cells remained viable on the scleral bed after the endoresection of the intraocular new growth, eliminating recurrences of tumours and metastases in the remote postoperative period.
SUBSTANCE: invention refers to medicine and can be used in ophthalmology and ophthalmic oncology for the scleral bed treatment following endoresection of an intraocular new growth. After the endoresection of the intraocular new growth, electrodes are intraocularly applied on the surface of the scleral bed, and electrochemical lysis is performed. The electrodes are gradually moved along the entire area of the scleral bed. That is followed by intravitreal heat treatment covering the entire area of the scleral bed and surrounding tissues by 1.5 mm.
EFFECT: method enables avoiding an ability to preserve viable tumour cells on the scleral bed and in the sclera thickness, provides the absence of recurrent tumours and metastases in the remote postoperative period.
3 cl, 1 ex
SUBSTANCE: invention relates to therapeutic devices for application in transcranial electrostimulation by the application of a respective electric impulse to ears simultaneously with playing music, which the patient hears. The device contains a generator of transcranial electrostimulation impulses, a generator of the sound signal, a control unit, a pair of audioearphones. The generator of transcranial electrostimulation impulses is made with a possibility of creating an electric impulse, which has such a frequency and duration as to provide the required microcurrent through the head. The control unit is made in the form of a microprocessor, controlling data of the electrostimulation impulse generator and the generator of the sound signal. Each audioearphone contains an electrode, transmitting electric current, for the application of the said impulses, produced by the impulse generator, into the area of the patient's ear. Each of the audioearphones and the respective electrode are combined into an electrode device, with the electrode of each electrode device being located on an external surface of the respective audioearphone, suitable for installation in an orifice of the auditory canal of the ear or inside it. The electrode of each electrode device has an area of electric contact for functional transmission of electric energy between the electrode and the patient's skin with the installed electrode device. The electrode devices are made with a possibility of installation in the orifice of the auditory canal of the respective ear of the said patient.
EFFECT: application of the invention increases convenience of carrying out electrostimulation and simplifies installation of the equipment on a patient.
6 cl, 6 dwg
SUBSTANCE: invention refers to medical equipment, namely to neurostimulation apparatuses. An apparatus comprises a device having a pulse generator for its supply on skin, a control unit, a probe with a number of electrodes connected to the control unit; the device is configured to determine a relative skin impedance, to localise an area of treatment on the basis of the relative skin impedance and to supply automatically a therapeutic pulse sequence on the basis of the pre-set relative skin impedance. According to the second version, the apparatus additionally comprises a gripping mechanism having a number of skin-contacting electrodes; the control unit is presented to determine a relative impedance of at least two of the whole number of electrodes for recording electrode-contacting skin impedance and to supply stimulation pulses to the electrodes on the basis of the recorded skin impedance. According to the third version, the probe comprises a number of spaced electrodes placed in a matrix; the matrix comprises a number of pairs of electrodes, and each pair of electrodes comprises neighbour electrodes having opposite polarities; the apparatus is configured to measure the skin impedance by the number of electrodes, to determine the relative impedance of the number of pairs of electrodes, to identify the area of treatment on the basis of the relative impedance, to transmit the pulse sequence into the area of treatment on the basis of the relative impedance of the pair of electrodes and to adjust the parameters of the pulse sequence in response to measuring the relative impedance of the pair of electrodes. According to the fourth version of the embodiment, the gripping mechanism comprises a number of electrodes comprising at least one first pair of electrodes mounted on the first probe to travel along the patient's skin to localise the active area on the basis of the skin impedance, and at least one second pair of electrodes mounted on the second probe to supply a pulse into the active area, while the control unit has at least one pre-set therapeutic parameter for setting variables of the generator to generate a pre-set pulse group and configured to provide a graphic selection of the above at least one pre-set therapeutic parameter by an operator by means of an interface.
EFFECT: using the invention enables to extend the range of technical aids for therapeutic neurostimulation.
35 cl, 49 dwg
SUBSTANCE: invention refers to medical equipment, namely to a system for data transfer between medical devices implanted into a subject's body using a volume conductivity of electric signals as a medium of communication. One of the implanted devices provides the electric stimulation of tissue. The system comprises two implanted devices, a coding aid using a canal as a transmission medium for stimulation pulses and coding the information in the stimulation pulses, and a decoding aid for the information coded in the stimulation pulses. The first implanted devices has two transfer electrodes transmitting the electric stimulation pulses therein one electrode may represent a general return electrode. The second implanted device has two pick-up coils receiving the transmitted stimulation pulses with the coded information transmitted through the canal. The first device is additionally configured for stimulating and receiving the information continuously in relation to evoked responses to the stimuli of the first device, measured by means of the second device, and sending a request to the second device on measuring the evoked response. The second device is additionally configured to provide the requested stimulation, to send the confirmation back and to transfer the parameters and/or characteristics of the measured signal to the first device.
EFFECT: system provides the reliable and effective communication between the implanted devices.
7 cl, 5 dwg
SUBSTANCE: invention refers to medicine. An extrascleral electrode is full-circle; it is made of a platinum mesh and provided with a handle.
EFFECT: using the invention enables forming the necrotic zones at the tumour volume.
FIELD: veterinary science.
SUBSTANCE: method includes the complex application of systemic antimycotic agents, surface antifungal agents, additionally the preparation Forvet is injected in a dose of 0.2 ml per 1 kg of mass subcutaneously, for 7 days.
EFFECT: increased efficiency of treatment, no side effects and reduced remission time.