Separation of flavouring agent from multi-layered film during cleaning

FIELD: medicine.

SUBSTANCE: invention relates to medicine and is intended for oral cavity care. Compositions include a multi-layered film and an orally acceptable carrier. The carrier contains the first flavouring agent, with the second flavour being contained in the present central layer of the multi-layered film, located between two external surface layers. The first and second flavouring agents can be similar or different. Each film layer can include a film-forming polymer, for instance, hydroxypropylmethylcellulose. The external layers can include a substance, modulating the release of the flavouring agent, for instance, polyvinylacetate or hydroxymethylcellulose. The carrier can be a means for teeth cleaning or a liquid for mouth rinsing.

EFFECT: obtaining the composition for oral cavity care.

22 cl, 3 dwg, 4 tbl, 11 ex

 

The LEVEL of TECHNOLOGY

This application relates to compositions for caring for the oral cavity, and more particularly to compositions comprising the multilayer film, embedded in a carrier, where the multilayer film includes a flavoring, which can be released during cleaning. Such compositions include, for example, for cleaning teeth, toothpastes and/or a liquid for rinsing of a mouth.

The flavors are an essential component for cleaning the teeth, and means for rinsing the mouth and is one of the most important features of a product for caring for the oral cavity. Flavor also plays a crucial role in the success of the application of a product for caring for the oral cavity. Good flavor not only increases the acceptability of the product, but also attracts consumers to buy the product again. Flavor provides not only a taste sensation on the tongue and the fragrance of the olfactory center of the nose, but also delivers the key signal which, when perceived by the brain, becomes closely connected with the features and quality of the product that influence the process of perception of the consumer.

Although currently some available products have met with consumer approval, there remains a need in the original products to care for the oral cavity, which can provide the zoom�nnow delivery of one or more flavours to the oral cavity of mammals.

Summary of the INVENTION

The present invention provides products to care for the oral cavity, which use multi-layer film technology to increase the supply of fragrance that provides extra flavor and other signals. As a result of use of the multilayer film, embedded in a suitable oral carrier composition for caring for the oral cavity, provided increased available supplies of flavoring, can be supplied in different and numerous signals of pleasant fragrances may change the profile of allocation of aromatizatora may be other signals in use of new components, and can be guaranteed to the consumer compliance with sanitary-hygienic norms. Also provided are methods of their use.

In one embodiment of the present invention, the composition for caring for the oral cavity, with an increased allocation of aromatizatora includes an orally acceptable carrier containing a first flavor and a multilayer film provided that the multilayer film includes at least a Central layer containing a second flavor, where the Central layer is located between two outer surface layers, and apply the flavors are the same or different.

In another embodiment, the implementation of the us�Mr sage invention is a composition for caring for the oral cavity, includes the multilayer film embedded in an orally acceptable carrier, where the multilayer film has a main layer containing the flavoring, and the Central layer is located between the two outer surface layers, each of which includes a film-forming polymer.

In yet another embodiment of the present invention is a composition for caring for the oral cavity, which comprises an orally acceptable carrier containing a first flavor and a multilayer film including:

a. the first outer surface layer;

b. at least the first Central layer containing a second flavor;

c. second outer surface layer, which may be the same or different from the first outer surface layer and the Central layer located between the first outer surface and second outer surface layer.
The present invention also provides a method for increasing the allocation of the flavour of the composition to care for the oral cavity, which includes the manufacture of a composition for caring for the oral cavity with an orally acceptable carrier containing a first flavor and a multilayer film, where the multilayer film includes at least a Central layer containing a second flavor, and Central �Loy is located between two outer surface layers, and first and second fragrances are the same or different, and the applied composition is intended to care for the oral cavity of a mammal.

In another embodiment of the present invention is a method of preparing a composition for caring for the oral cavity comprising the multilayer film with a flavor that is embedded in an orally acceptable carrier, which includes:

a. do orally acceptable carrier containing a first flavor;

b. the addition of a multilayer film, comprising at least a Central layer containing a second flavor, where the Central layer is located between two outer surface layers, and first and second fragrances are the same or different; and

c. homogenization of the mixture.

Compositions and methods of the present invention have advantages in comparison with the compositions and methods known in this field. Such advantages include the ability to provide advanced delivery system aroma that deliver intense burst of fragrance during use of the composition for caring for the oral cavity, for example, while brushing your teeth or rinse his mouth with mouthwash. Compositions for caring for the oral cavity of the present invention also have enhanced properties and improve the aesthetics�internal stability in the supply of fragrance and other strong feelings such as the perception of coolness, a tingling sensation that signals the sweetness and warmth. Other advantages and embodiments of the present invention will become apparent from the detailed description set forth herein.

BRIEF description of the DRAWINGS

Preferred embodiments of the invention are described in the following illustrated with some examples and attached figures, in which:

figure 1(a) illustrates the profile selection aroma of A toothpaste containing multi-layer flavored chips of the present invention;

figure 1(b) illustrates the profile of allocation of the flavor of your regular toothpaste B, which does not contain any flavored chips;

figure 2 illustrates a three-layer film in which a Central or core layer contains the flavoring, and two outer surface layers with no flavoring.

DETAILED description of the INVENTION

The present invention provides compositions for caring for the oral cavity and means for insertion or application of human or other animal subject. Preferably, the specific materials and compositions for use in this invention was accordingly farmatsevticheskii or cosmetically acceptable. As used herein, terms such as "pharmaceutically acceptable" or "�osmeticheskie acceptable" component, implied here is one of those components, which is suitable for use with humans and/or animals to provide the desired therapeutic, sensory, decorative, or cosmetic benefit without undue adverse side effects (such as toxicity, astringent taste, irritation and allergic response) commensurate with a reasonable ratio of benefit/risk. The following definitions and non-limiting guidelines must be considered when reading and interpreting the description of this invention set forth in this document.

The headings (such as "prior art" and "the invention") used herein are intended only for General organization of topics discussed within the disclosure of the invention and are not intended to limit the disclosure of the invention or any aspect of it. In particular, the content of the subject matter disclosed in the "prior art" may include aspects of technology within the limits of the invention and may not constitute the transfer of the prior art. The content of the subject of discussion in "the invention" is not intended to be exhaustive or fully revealing the scope of the invention or any embodiment of.

The inclusion in this document of references is not seen as a recognition that these links are pre cursors�following the prior art, or have any relevance to the patentability of the invention described in this document. All references cited in the description section of this invention, incorporated in this document by reference in full.

Description and specific examples showing embodiments of the invention, are intended for illustrative purposes only and are not intended to limit the scope of the invention. Enumeration of multiple embodiments of the invention, have characteristics that are not intended to exclude other embodiments of the invention having additional features, or other implementation options, including various combinations of these features. Specific examples are presented to illustrate how to make, use and practice the compositions and methods of this invention and, unless explicitly specified, list the steps that have been made (i.e., using the past tense), they are not intended to be asserting that these embodiments of this invention may or may not be executed.

Used in this document, the words "preferred" and "preferably" refer to embodiments of the invention, which represent certain privileges in certain circumstances. The n� less other options for implementation may also be preferred, under the same or other circumstances. In addition, the enumeration of one or more preferred embodiments of the invention does not imply that other embodiments of the invention are not useful, and does not exclude them from the scope of the invention.

Used here, the word "include" and its variants are intended not to limit, therefore, the enumeration of the other paragraphs in the list, and does not exclude such items that may also be useful in the materials, compositions, devices and methods of the present invention. Similarly, the description of certain advantages or disadvantages of the known materials and methods are not intended to limit embodiments of the invention and their exceptions. Indeed, some of the options for implementation may include one or more known materials or methods, without suffering from their disadvantages, described in this document.

Used in this document, the term "approximately" indicates a possible change in the size of the value to 5%.

Compositions for caring for the oral cavity in the form of various embodiments is preferably applied in the form of means on care of teeth. The term "means to care for teeth" used in�him that description means paste, gel, tablet, chewing gum or liquid formulation. The dentifrice may be in any desired form, such as a thick stripe, striped surface, a multilayer having the gel surrounding the edge of the paste, or any combination of them. The film is contained in a composition for caring for the oral cavity may have any desired shape or structure, including numerous small strips or one continuous strip.

The expression "carrier" or "carrier liquid" is used throughout this description refer to any safe or effective materials for use in the present invention. Such materials include, for example, thickeners, moisturizers, ionic active ingredients, buffering agents, substances that prevent the formation of Tartar, abrasive polishing materials, peroxide sources, bicarbonate alkali metal salts, surfactants, titanium dioxide, colorants, flavorings, sweeteners, antimicrobial substances, herbal remedies, remedies that reduce irritation, reduce stains, and mixtures thereof.

The present invention provides compositions for caring for the oral cavity comprising the multilayer film embedded in an orally acceptable carrier, where the multilayer film contains at least a Central layer containing flavoring, at least one outer surface layer comprising a film-forming polymer. Used in this document, the term "composition for the care of the oral cavity" refers to compositions for which the intended use can include care for the oral cavity, oral hygiene or intraoral appearance, that is, for which the intended method of use may include the introduction of the preparation in the intraoral cavity. Embodiments of the invention include a multilayer film.

As mentioned in this document, the term "film" is a material having, basically, a layered structure. "Layered" structure has or may have the size in one or two dimensions (e.g., x - or y-direction) that is substantially larger than the thickness of the structure in the third dimension (e.g., z-direction). Layered structure, useful in the present invention include those structures that are mostly flat, layered or lamellar. In one embodiment, the implementation, the layered structure is substantially flat, having a size in both x - and y-directions are substantially larger than the size in the z-direction. In other embodiments, the layered structure is non-planar. In one embodiment of the film of this invention forms, in the main�m, continuous surface that may seem substantially flat surface, although in some embodiments, likelihood of deformation. In such embodiments, the film may be any one of many forms, including the existence of a smooth curve surface. Fragments can be the right size and can be right or wrong perimeter.

In one embodiment of the present invention, the multilayer film contains at least a Central layer containing flavoring and the two outer layers surrounding a Central layer. Each layer of the film comprises at least a film-forming polymer, film-forming substance from starch, sweetener, wetting agent and surfactant. The Central layer further comprises a flavoring. In another embodiment of the multilayer film of the present invention contain many of the Central layers, each of which can comprise a flavoring.

The main film-forming material used for the production of multilayer films of the present invention is hydroxyalkyl cellulose, such as hydroxypropylmethyl cellulose, hydroxypropyl cellulose, hydroxyethylcellulose, hydroxyethylmethylcellulose, hydroxyethylmethylcellulose, HYDR�climatically and carboxymethylcellulose. Preferably, the cellulose polymer represented low viscosity polymer of hydropolitical (HPMC). When HPMC is used as film-forming substance, it is preferable that HPMC had a viscosity in the range from about 1 to 40 millipascal second (MPa·s), the same as defined in 2% by weight aqueous solution of HPMC at 20°C using an Ubbelohde viscometer tube. Preferably, the HPMC had a viscosity of about 3 to 20 MPa·s at 20°C.

HPMC is commercially available polymer from Dow Chemical company under the trademark Methocel E5 LV. Methocel E5 LV USP grade is a low viscosity HPMC having 29.1 percent methoxyl groups and 9% hydroxypropyl substitution groups. It is a white or almost white free-flowing powder. The viscosity of aqueous 2 mass. % solution, measured with a Ubbelohde viscometer tube, is 5.1 MPa.C at a temperature of 20°C.

Hydroxyethylmethylcellulose included in the composition of the layers of the multilayer film in an amount of from 25 to 75% by weight and preferably from 40 to 55% by mass.

Swelling in cold water, physically modified, pre-gelatinisation starches are particularly suitable as a modifier of the structure to increase the rigidity hydroxyethylmethylcellulose multilayer films of the present invention. In preparing such products�Chow from starch, granular starch is treated in the presence of water and possibly an organic solvent at a temperature above 10°C compared with the temperature of gelatinization. The resulting starch is then dried.

Pre-gelatinizing corn starch is a commercially available product. The preferred starch is available under the trademark Cerestar Polar Tex Instant 12640 from the company Cerestar. This Cerestar starch is pre-gelatinization, stable, cross-linked and waxy corn starch. It easily disperses and swells in cold water. In dry form it is a white free-flowing powder with an average size of the plate not more than 180 micrometers (μm), and with 85% of records, the size of which is less than 75 microns. He has a bulk density of 44 lb/ft3.

Starch Cerestar perfect stored in a cold room and remains stable during freezing/thawing. It has a high rate of hydration and can reach very high viscosity without heat treatment. It has a smooth and creamy structure similar to the above-mentioned starches. He also has excellent transparency and light fragrance.

Pre-gelatinizing starch may be present in the matrix film of the present invention as the binder in the amount ol�from about 0 to about 50% by weight and preferably from about 10 to about 20% by mass.

Sweeteners can also be included in the composition of the layers of multilayer films of the present invention and consist of natural and artificial sweeteners. Suitable sweeteners include water-soluble substances such as monosaccharides, disaccharides and polysaccharides such as xylose, ribose, glucose (dextrose), mannose, glucose, fructose (levulose), sucrose (sugar), maltose, water soluble artificial sweeteners such as soluble some saccharine salts, i.e. sodium or calcium salt of saccharin, cyclamate salt-based sweet dipeptides, such as L-aspartic acid, from which he received sweeteners such as the methyl ester of L-aspartyl - L-phenylalanine or aspartame). In one aspect of the present invention sweetener based D Sucralose is preferred.

Generally, an effective amount of sweetener is utilized to provide the desired level of sweetness for a specific matrix composition of the film and will vary from the selected sweetener. This amount will generally be from about 0.01% to about 2% by weight of the composition. However, in some embodiments, an additional amount of sweetener may be added to toothpaste directly to ensure continuously�about the perception of sweetness throughout the period of use.

In some embodiments of the present invention, it is desirable to increase the ability to absorb moisture multilayer film by adding surfactants. Can be any orally acceptable surfactant, most of which are anionic, nonionic or amphoteric. Suitable anionic surfactants include without limitation water-soluble salts of alkylsulfates C8-20, sulfonated monoglycerides of fatty acids (C8-20, sarcosinate, taurate and the like. Illustrative examples of these and other classes include sodium lauryl sulfate, sodium coconut monoglyceride sulfonate, laurylsarcosine sodium, laurieston sodium, eurekabuild sodium and dodecylbenzensulfonate. Suitable nonionic surfactants include, without limitation poloxamer, esters of polyoxyethylenesorbitan, ethoxylate fatty alcohols, alkylphenolethoxylates, tertiary amine oxides, tertiary phosphine oxides, diallylsulfide and the like. Suitable amphoteric surfactants include without limitation derivatives of aliphatic secondary and tertiary amines C8-20having an anionic group such as carboxylate, sulfate, sulfonate, phosphate or phosphonate. Under�adashim example is cocamidopropylbetaine.

Food nonionic surfactants are preferred. Examples of edible non-ionic surfactants that may be used include: complex polyoxyethylene esters sorbitan and fatty acids, polyoxyethylenesorbitan esters and polyoxyethylene derivatives of castor oil. An example of a suitable commercially available nonionic surfactants that may be used is Polysorbate 80, which is a mixture of esters of oleic acid and sorbitol anhydrides consisting predominantly of monoether, condensed with about 20 moles of ethylene oxide. Polysorbate 80 sold under the trademark Tween®80 from ICI Surfactants and is most preferred for the multilayer films of the present invention. The HLB value of the complex polyoxyethylenated ether sorbitan and fatty acids should be more than 10, but should not exceed 20. The inclusion of surfactants proved to be very useful in many cases. One or more surfactants optionally present in a total quantity from 0.01% to 10%,such as from 0.05% to 5% or from 0.1% to 2% by weight of the composition.

The Central or core layer of multilayer films of the present invention preferably includes at least one� flavouring substance. Substances with aromatic compounds included in the compositions of the multilayer films of the present invention, as is known in the prior art, were both natural, and artificial flavors. These pleasant smells can be chosen from synthetic oils and flavoring aromatics and/or oils, jevic and extracts derived from plants, leaves, flowers, fruits and so forth and combinations thereof. Representatives of aromatic oils include: spearmint oil, cinnamon oil, peppermint oil, clove oil, Bay oil, thyme oil, cedar oil, oil of nutmeg, oil of sage, oil of bitter almonds. These substances with a pleasant odor can be applied individually or in a mixture. Commonly used flavors include: scents of mint, such as peppermint, artificial vanilla, derivatives of cinnamon, various fruit flavors, or used individually or in mixture. Usually can use any flavoring or food additive, which is described in the publication of the Chemicals Used in Food Processing, publication 1274 by the National Academy of Sciences, pages 63-258. Typically, the flavoring is included in the film of the present invention in an amount of from 1 to 60% by weight, preferably from 5% to 40%, more preferably from 15 to 25% by mass.

Profile selection of fragrance during cleaning or rinsing �you can manage trimming the thickness and/or composition of the outer surface layers. The thickness of the outer surface layers can vary from 0.2 mils to 4 mils, preferably between 0.3 and 0.75 mils mils.

Without limitation by theory, it is believed that upon contact with saliva or water flavored chips multilayer film of the present invention slowly begin to disintegrate, as each layer and especially the outer surface layers under the action of the water is exposed to erosion. In addition, when brushing teeth, toothpaste or mouthwash that contains flavored chips multilayer films, emit a burst of flavor as brushing or rinsing the mouth also causes mechanical destruction of flavored chips, leading to an immediate allocation of the flavoring component from the core layer of the multilayer film flavored chips. The inclusion of flavored chips multilayer film in a dentifrice or mouthwash, the consumer can use of a composition for caring for the oral cavity that have increased the supply of fragrance. As the scent of toothpaste or dental elixir weakens, it increases the release of flavor from a multilayer film flavored chips, as distinguished flavor from the base layer of multi-stakeholder�been on film flavored chips and elevated consumer experiences a prolonged sensation of flavor after as the fragrance from a conventional toothpaste decreased. Example 1 (b) illustrates this mechanism with time delay, after which the flavour of the multilayer film outstanding.

In one embodiment of the present invention, the flavor of the toothpaste is enhanced by the addition thereto of flavored chips multilayer film of the present invention, where the flavor of the chips is the same as toothpaste.

Extra flavour can be supplied when changing the type of flavoring in the multilayer films of the present invention. When the flavoring of toothpaste and another in the multilayer film are the same, then the intensity of fragrance during cleaning of the teeth increases.

In another embodiment of the present invention, the aromatic perception can be changed with time due to the inclusion in the orally acceptable carrier is a multilayer film having a structure AB, ABA or ABC. Other structures of multilayer films, such as ABAB or ABC ABC also apply. In these film structures A represents the outer surface layer that includes a film-forming polymer selected from the group consisting of hydroxymethylcellulose, of methylcellulose hydroxypropyl cellulose and mixtures thereof copolymers. The outer surface layer of A would prefer�till then include corn starch, sweetener, such as D Sucralose, humectant, such as propylene glycol and a surfactant, such as Tween 80. The surface layer A may include other components that may delay or accelerate the release of flavor from the Central layer. Such components include, but are not limited to, polymers modulation selection, such as polyvinyl acetate or hydroxyethyl cellulose. The thickness of the outer surface layers can be changed and, thus, also affect the release of flavor from the Central layer. When the outer surface layers are thin or are about 0.2 mil, accelerates the release of flavor from the Central layer. Conversely, when the outer surface layer of increased thickness, for example up to 4 mils, the delays in the release of flavour from the Central layer. Preferably, the thickness of the outer surface layers was approximately 0,55 mil. The Central or core layer B may include the same components as the outer surface layer A, however, the layer B also contains fragrance, which can be the same or different from flavoring orally acceptable carrier. The Central layer B may also include other components that may provide additional signals vesprit�I in addition to increased signal of the fragrance. When the structure is ABA, the selection of flavors takes place in different times, following the diagram, which is discussed below, in accordance with figure 1. In a multilayer film structure ABC the perception of a fragrance also varies over time. For example, from a three-layer ABC patterns multilayer film of toothpaste can gradually allocated citrus flavor from the layer C for 30 seconds, starting at the beginning of cleaning. After the layer C is completely dissolved, then one surface of the layer B remains open and can be allocated a second flavor, similar to a strong ehlargement smell of mint. If A layer will have different rate of dissolution (or thicker) than the layer C, the increase in the rate of allocation of the smell of mint, like a strong cool from a layer B, will be seen once a layer is completely dissolved, and opened the second surface of the layer B.

In one embodiment of the present invention, the change in the external composition of the surface layers can be used to control the timing of the selection signal of the second flavor of toothpaste or dental elixir, which include the multilayer film flavored chips of the present invention. For example, the extraction of flavor from the Central layer may be deferred by adding exterior over�ostrye layers of polymer, modulating the release, such as polyvinyl acetate, hydroxyethyl cellulose and similar in amounts effective to delay the allocation of flavour from the outer layer to the desired term. For example, by adding from about 1 wt. % to 5 wt. % of polyvinyl acetate, the release of fragrance when cleaning can be delayed for 1-5 minutes, ensuring, thus, the surge in the selection of the fragrance at the end of the cleaning process. This can be useful, in order to signal the user that the cleaning process long enough.

In another embodiment of the present invention, the change in the thickness of the outer surface layers can be used to control the alarm time the second flavor of toothpaste that includes flavored chips multilayer films. For example, the thickness of the outer surface layers can vary from 0.2 mils to 4 mils.

In yet another embodiment of the present invention presents a toothpaste that can deliver a signal of the second flavour with intensity different from the intensity of the signal of the first flavour multi-layer flavored chips. This can be achieved by changing the concentration of flavour in the slurry composition used for Central or primary film layer of the multilayer film aromatic�aligned chips. For example, the level of flavour in the Central or core layer can vary from 5% to 40% by weight of the composition of the Central or core layer.

In various embodiments of the present invention, preparing a multi-layer flavored chips with a flavor that is different from the flavor of the basics of toothpaste, you can obtain tooth paste which may then file a second signal of the fragrance, which is different from the first signal.

In other various embodiments of the present invention, the chips multilayer film may be prepared for delivery of other signals in addition to signals of fragrance in which the fragrance of the base layer is supplemented with one or more substances selected from the group consisting of substances that supplies a signal to a feeling of coolness, a signal or a tingling sensation that signals the sense of sweetness, the signal feelings of warmth or their mixtures.

Examples of substances of feeling of coolness, which provide a strong feeling of coolness, include without limitation menthol, WS-3TM, WS-5TM, WS-23TMand L-Mantellate. Examples of substances tingling sensations that provide a strong tingling sensation include without limitation spilanthol and capsaicin. Examples of substances the sensation of sweetness, which provide a strong sense of sweetness, include without limitation �aherin, the energy, aspartame, neotame, and Acesulfame-K. Examples of substances sensation of warmth, which provide a strong feeling of warmth, include without limitation cinnamic aldehyde, capsaicin, zeolites, capsicum and SAP.

The thickness of the multilayer film is from 1.0 mils to 10 mils, preferably from 1.5 mils to 4 mils. The dried film of the present invention can then be cut or it can be engraved plates having a size of from 0.01 to 0.50 inches, preferably from 0.08 to 0.25 inches.

When the film is to be used for decorative effect, then, once formed, can carving various attractive forms of records, such as hearts, stars, diamonds and circles. Plates film can be included in the basis of means for care of teeth of the present invention in a concentration of approximately from 0.05 to 2.0% by mass, and preferably from 0.2 to about 0.75 percent by weight.

Multilayer films of the present invention can be prepared using methods known in this field, such as conventional extrusion, injection molding processes using water and solvents. In one embodiment of the present invention provides a three layer film. Three layer films can be formed by the sequential formation of layers A, B, A by casting from suitable�of a liquid solution, followed by drying each layer. For example, the first layer may be cast from a liquid solution with a composition comprising a film-forming polymer in a layer thickness of 5 mil and then dried for 15 minutes in a drying Cabinet at a temperature of 95°C. Then a second layer can be cast on the first layer of the composition of the fluid solution comprising a film-forming polymer and flavoring, in a layer thickness of 15 mil and then dried for 15 minutes in a drying Cabinet at a temperature of 95°C. Finally, the third layer may be cast on the second layer of the composition of the fluid solution comprising a film-forming polymer, in a layer thickness of 5 mil and then dried for 15 minutes in a drying Cabinet at a temperature of 95°C. the Experts in this field are well known to other means to obtain a 2-layer, 3-layer and multilayer films, they include a casting with the use of aqueous solutions, casting with the participation of the solvent, extruding and the like. Films can be made sequentially as shown above, or be formed as a multilayer laminated suspension components directly from suspensions. Layered slurry was then dried in a similar manner. Combinations of methods are also possible. For example, for extrusion layers can follow different layers, obtained by casting from solvent. The purpose of this description is not limiting JV�soba control film. After the multilayer film is prepared, they can be cut into smaller pieces of different geometry or, for example, forms for samples of chips, and used for inclusion in the basis of the toothpaste or the basis of dental elixir.

In another embodiment of the present invention presents a three-layer film in which the outer surface layers are subjected to dissolution by water and include a first film-forming polymer, while the Central layer includes a fragrance and a second film-forming polymer, which may be the same or different.

All benefits provided by the multilayer films of the present invention, also shown in figure 1. Figures 1(a) and 1(b) illustrate typical profiles highlight the flavor of toothpaste A or toothpaste B, measured by determining the amount of flavoring in the saliva taken during the cleaning time. Toothpaste contains A your own flavor as well as the 3-layer film flavored chips made from 3-layer film having the structure ABA, as shown in figure 2, in which outer surface layers made of A same composition and the base layer B is a single layer containing a flavoring. Toothpaste B does not contain any aromatize�avannah chips and the content of the flavoring of your regular toothpaste. As shown in figure 1 (a), initially, the profile of allocation of the flavoring of toothpaste A follows the release profile of conventional toothpaste B in figure 1(b). However, once the aroma from the basics of toothpaste decreases, and as 3-layer flavored chips begin to melt, the flavor stands out from a Central layer after the delay period and a consumer experiences a sudden and intense burst of flavor. As described in more detail below, the intensity of the burst of flavor varies depending on the amount of flavoring in the Central layer of the multilayer film chip of the present invention.

Figure 2 illustrates a 3-layer film having the structure ABA, in which the outer surface layers are made of the same compositions.

In various embodiments of the present invention of a composition for caring for the oral cavity include a variety of laminated multilayer film fragments, distributed in the media. In one embodiment of the composition includes a multilayer film, where the film consists of lamellar fragments of the film material. In one embodiment of the present invention, the composition includes a carrier with distributed therein a variety of lamellar fragments, wherein the fragments are composed of a multilayer film, where the main� layer contains the flavoring. Such fragments can have any variety of shapes or forms, including semi-solid or solid pieces, pieces, particles, flakes, or combinations thereof. In various embodiments, the present invention multi-layer film includes a first fragments and second fragments, where the fragments is different in composition or appearance from the second plurality of fragments. This difference in composition or appearance can be in any variety of the composition of the fragment (for example, the various components of the film, different functional material, different chemical composition of the dye), different appearance (e.g., shape, color, texture, refractive index, reflectance), or a combination thereof.

In various embodiments of the present invention, the fragments show a marked contrast with the media. In marked contrast may be a touch of contrast, such as optical contrast, tactile contrast, the contrast of taste or contrast of smell. In some configurations, the optical contrast can be color or contrast can have a difference in refractive index or reflectance. In some configurations, the color contrast can be transferred from one or more dyes that include various components components�icii. In various embodiments, the present invention includes a composition comprising a plurality of film fragments in the media in which these fragments are clearly visible. As indicated in this document, the term "apparent" refers to one or more characteristics of the fragment, which cause the fragment to have a different appearance, preferably visible to the naked eye, relative to the carrier where the fragment is. These characteristics include: color, opacity, refractive index, reflectance, size, shape, and combinations thereof.

In various embodiments of the present invention, the tiles are non-random shape. In one embodiment of the present invention, the term "non-random" shape is a shape which is obtained during the manufacturing process of forming, cutting, or other manufacturing process that determines the form that was passed to the fragment. In such embodiments, the present invention is not accidental form differs from these forms, which are the result of simple sedimentation or grinding material. In one embodiment of the present invention "non-random" shape is "repetitive" where the composition contains a lot of pieces that are mostly the same �Amou form. Kind of repetitive form can have any many forms and can be selected on the basis of different aesthetic and functional criteria. In some embodiments of the present invention the shape of the piece of film can be a recognizable form. In some embodiments of the present invention a fragment of a multilayer film may contain a non-random shape. Such forms include simple geometric shapes, such as polygons and elliptical shapes, such as triangles, quadrilaterals (e.g., square, rectangle, rhombus), pentagons, hexagons, ellipsoids and circles. In one embodiment of the present invention, the repeating shape is a square. Duplicate form in another embodiment of the present invention are the forms that are typical for images of animate or inanimate objects, such as stars, hearts, gems, flowers, trees, shamrocks, letters of the alphabet, numbers, animals, people and faces. In various embodiments of the present invention the composition comprises a single repeating shape. In other embodiments of the present invention the composition comprises a multitude of fragments having a plurality of repetitive shapes. In one embodiment of�of westline present invention, the compositions include a set of rst fragments of the multilayer film, having first repeated shape and multiple fragments of the second multilayer film having a second repeated shape, with the first repeated shape is different from the second duplicate of the form.

In various embodiments of the present invention the size of the fragments is not particularly important and can be determined in accordance with any variety of criteria, including manufacturing convenience, the impact on the appearance, the surface area, the impact on the structure of the composition, and combinations thereof. In some embodiments of the present invention the multilayer film fragments can be up to about 1 inch (25.4 mm) along the length of the longest dimension. As indicated herein, the term "longest dimension" is the dimension of the fragment of the length or width (i.e., in the x - and y-dimensions, because the fragment may be distorted and not in a flat shape), dimension essentially perpendicular to the "thickness" or the shortest dimension of the fragment (i.e. the z-dimension). It is clear that in various embodiments of the present invention comprising a plurality of fragments, the fragments may be present in a range of sizes due to a number of factors, including random variation in size, manufacturing tolerances and deliberate calibration or mixing fragmento� due to sorting or something similar. As described herein, the sizes refer to the average size of fragments in this set of fragments.

In various embodiments of the present invention the size of the fragments ranged from approximately 0.2 mm to approximately 15 mm in length. In various embodiments, the length dimension of the fragments is from 0.2 mm to approximately 10 mm, from about 0.5 mm to about 10 mm, from about 0.8 mm to about 8 mm, from about 0.9 mm to about 5 mm, from about 1.0 mm to about 5 mm or from about 1.5 mm to about 2.5 mm. In some embodiments, the length dimension of the fragments is at least about 3 mm and may be from about 6 mm to about 13 mm. In some embodiments, multiple portions of the film are the longest size bigger than about 600 microns. In some embodiments of the present invention, fragments of the film have the longest size larger than approximately 1 mm.

In various embodiments, the fragments of the present invention have a thickness from about 1 mil (one thousandth of an inch, 25.4 microns) to about 3 mils (76.2 microns). In various embodiments, the thickness of the fragments is approx�siteline less than 4 mils or approximately less than 100 microns, and from about 0.1 mil (2.54 microns) to about 10 mils (254 microns), from about 0.5 mil (12.7 microns) to about 5 mils (127 microns), from about 1.4 mil (35.6 microns) to approximately 2.0 mils (50.8 microns).

In some embodiments, the compositions of the present invention include fragments having the ratio of the geometric dimensions of at least approximately 5:1. As mentioned herein, the expression "the ratio of the geometric dimensions of" fragment represents the ratio of the diameter of the smallest imaginary sphere that can contain the object to the diameter of the largest imaginary sphere that can be completely inside the object on its surface. For example, the geometric ratio of the size of the sphere is 1:1; in another example, the ratio of the geometric dimensions of the cylinder, whose size is 2 inches (50.8 mm) in length and 1/4 inch (6.35 mm) in diameter is slightly over 8:1; in yet another example, the fragment of a multilayer film of the present invention, the size of which is 1 mil(25.4 microns) in thickness, 1 inch (25.4 mm) in length and 1 inch (25.4 mm) in width, the ratio of the geometric dimensions of approximately 14:14:1.

In some embodiments of the present invention, the composition comprises fragments having the ratio of the geometric dimensions of at least approximately 10:1. In various parentadolescent present invention, fragments of the ratio of the geometrical sizes is from 5: 1 to 10,000: 1, from 5: 1 to 500: 1, from 10: 1 to 1,000: 1, from 10: 1 to 100: 1, from 20: 1 to 100: 1 or from 25: 1 to 35: 1.

In various embodiments, the present invention multi-layer film includes the development of dye that imparts color to a multilayer film, song, or both of them. In various embodiments of the present invention, portions of the film are contrasted with the carrier and are white, black or any color that is visible or contrast to the background medium. The dye composition, applied in the present invention include non-toxic paints or pigments, such as, for example, metal oxide "varnishes". In some embodiments, the implementation of the present invention, the dye is intended for inclusion in food or medicine is allowed to use in the government regulatory bodies, for example, FD&C or D&C pigments and dyes approved by the FDA for use in the United States. Dyes, among substances used in the present invention contain: FD&C Red No. 3 (red) (sodium salt of tetraiodofluorescein) Food Red 17 (red food) (disodium salt of 6-hydroxy-5-{(2-methoxy-5-methyl-4-sulfophenyl)azo}-2-naphthalenesulfonic acid), Food Yellow 13 (yellow-food grade) (sodium salt of mixture of mono - and disulfonic acids of chieftan) or 2-(2-chinolin) intention, FD&C Yellow No. 5 (yellow) (�atieva salt of 4-p-sulfophenylazo-1-p-sulfophenyl-5-hydroxypyrazol-3 carboxylic acid), FD&C Yellow No. 6 (yellow) (sodium salt of p-sulfophenylazo-B-naphthol-6-monosulfonic), FD&C Green No. 3 (green) (disodium salt of 4-{[4-(N-ethyl-p-sulfanilamide)-vinyl]-(4-hydroxy-2-sulfonatophenyl)-methylene}-[1-(N-ethyl-N-p-sulfobutyl)-Δ-3,5-cyclohexadiene], FD&C Blue No. 1 (blue) (disodium salt of the anhydrite dibenzylidene-diaminodiphenylamine of trisulphonate), FD&C Blue No.2 (blue)(sodium salt of dissolvability of indigotin) and their mixtures, in varying proportions. In one embodiment of the present invention, the colorant comprises a water insoluble inorganic pigment, such as titanium dioxide, chromium oxide green, phthalocyanine green, ultramarine blue, iron oxide or water-insoluble lacquer dyes. In some embodiments of the present invention include Lac-dye calcium or aluminum salts of FD&C dyes such as FD&C Green #1 (green) lacquer, FD&C Blue #2 (blue) lacquer, D&C Red #30 (red) lacquer or FD&C # Yellow 15 (yellow) varnish. In some embodiments, the present invention is a water-soluble dye such as FD&C Green #1, a part of the water-insoluble polymer, such as polyethylene, which is located in plastic beads (e.g., Microblue Spectrabeads sold by Micropowders, Inc.). In some embodiments of the present invention a multilayer film� includes a dye such as D&C Red #30 (red). In some embodiments, the present invention is applied white pigment, e.g. titanium dioxide (TiO2), titanium dioxide coated mica (e.g., Timiron), mineral or clay. In certain embodiments of the present invention the dye is Nelineinaya paint. In various embodiments, the present invention multi-layer film comprises a colorant at a level from about 0.5% to about 20% by weight of the multilayer film, or from about 1% to about 15% by weight of the multilayer film, or from about 3% to about 12% by weight of the film. In one embodiment of the present invention contains the first set of fragments multilayer film comprising a first dye and a second set of multilayer film fragments comprising a second dye. Preferably, the second colorant different from the first dye.

Multilayer film of the present invention in various embodiments disintegrates into its component parts during use of the composition. In other embodiments, the present invention multi-layer film during use of the composition does not break up into its constituent parts. In some embodiments of the present invention �mnogosloyna film secretes a substance such as air freshener in the media. As mentioned in this document, the term "to break into constituent parts" refers to the physical destruction of the multilayer film or piece of material so as to obtain a film or film fragments of reduced size compared to the original film. Such destruction may be accomplished by mechanical, chemical or physico-chemical means. The collapse may be the result of, for example, shearing, crushing or exposure to elevated temperature during use. In various embodiments of the present invention such results in the destruction of the composition of toothpaste occur when brushing your teeth a subject using the composition. In one embodiment of the present invention, the film disintegrates into its component parts in order to release the functional material of the fragrance (as described later in this document). In some embodiments of the present invention, a fragment of the film can disintegrate into small particles, which is not visually noticeable. In some embodiments, portions of the film are destroyed, together to form a colloid or gel.

In various embodiments of the present invention, a multilayer film may include, in addition to flavoring substance without as�x restrictions other functionally active substance, such as:

A. masking odorants, such as ionone;

B. bacteriostatic or antibacterial agents such as Magnolia bark extract, magnolol, honokiol, triclosan, zetiaprednisone (CPC), chlorhexidine, etc.;

C. metal salts of bismuth, zinc, tin, copper, etc.

In various other embodiments of the present invention, a multilayer film may include, without limitation, in addition to flavoring substance other therapeutically active substances. As mentioned herein, therapeutically active substances are material, which is useful for the prevention and treatment of physiological disorders or diseases. Such disorders or diseases include those in the oral cavity (including teeth and gums), skin, hair and eyes. The specific therapeutically active substance is preferably determined according to the desired use of the composition. In one embodiment of the present invention, the allocation of flavour sends an important signal to the user that therapeutically active substance is sufficient time for effective work in the oral cavity. Such active substances include the following:

A. Antibacterials, such as triclosan, zetiaprednisone, domiphen bromide, Quaternary ammonium salt, �sanguinarin, fluorides, actinidin, ethylenediaminetetraacetic acid EDTA, essential oils such as thymol, methyl salicylate, eucalyptus, menthol and the like;

B. nonsteroidal anti-inflammatory drugs such as aspirin, acetaminophen, ibuprofen, Ketoprofen, diflunisal, fenoprofen calcium, naproxen, tolmetin sodium, indomethacin and the like;

C. remedies against cough, such as benzonatate, caramiphen edisylate, menthol, dextromethorphan hydrobromide, chlorphenol hydrochloride and the like;

D. decongestants, such as pseudoephedrine hydrochloride, phenylephrine, phenylpropanolamine, pseudoephedrine sulfate, and the like;

E. antihistamines, such as brompheniramine maleate, chlorpheniramine maleate, carbinoxamine maleate, clemastine fumarate, dexchlorpheniramine maleate, diphenhydramine hydrochloride, diphenylpyraline hydrochloride, azatadine maleate, diphenhydramine citrate, doxylamine succinate, promethazine hydrochloride, pyrilamine maleate, tripelennamine citrate, triprolidine hydrochloride, acrivastine, loratadine, brompheniramine, dexbrompheniramine and the like;

F. expectorants, such as guaifenesin, Ipecacuanha, potassium iodide, terpin hydrate, and the like;

G. Antidiarrheals, such as loperamide, and the like;

H. H2-antagonists such as famotidine, ranitidine, and the under�training;

I. proton pump inhibitor such as omeprazole, lansoprazole and the like;

J. General nonselective depressants of the Central nervous system (CNS), such as aliphatic alcohols, barbiturates and the like;

K. General nonselective stimulants of the Central nervous system (CNS), such as caffeine, nicotine, strychnine, picrotoxin, pentylenetetrazol and the like;

L. drugs that selectively modify the function of the Central nervous system (CNS), such as felicitation, phenobarbital, primidone, carbamazepine, ethosuximide, methsuximide, phensuximide, trimethadione, diazepam, benzodiazepines, phenacemide, featured, acetazolamide, Altium, bromide and the like;

M. drugs of ANTIPARKINSONISM, such as levodopa, amantadine and the like;

N. narcotic analgesics, such as morphine, heroin, hydromorphine, metopon, Oxymorphone, Levorphanol, codeine, hydrocodone, oxycodone, nalorphine, naloxone, naltrexone and the like;

O. analgesic-antipyretics such as salicylates, phenylbutazone, indomethacin, phenacetin and the like;

P. psychopharmacological drugs such as chlorpromazine, methotrimeprazine, haloperidol, clozapine, reserpine, imipramine, tranylcypromine, phenelzine, lithium and the like.

The amount of medication that can be used�owano in the films of the present invention, may depend on the dose needed to ensure the effectiveness of the drug.

In various embodiments, a therapeutic agent used in the present invention include anti-caries funds, funds that reduces formation of Tartar, plague control means, periodontal means, breath freshening, odor control, whitening agents, antibacterial agents, steroids, anti-inflammatories, vitamins, proteins, conditioning agents, moisturizers, antiperspirants funds, deodorants, anaesthetics and mixtures thereof.

In some embodiments, the implementation of care for the oral cavity of the present invention multi-layer film or a composition for caring for the oral cavity may include an active substance to care for the oral cavity, which is useful for the prevention or treatment of oral diseases. Active substances for the care of the oral cavity among the mineral substances used in this document include abrasives, anti-caries funds, funds that reduces formation of Tartar, plague control means, periodontal funds, funds, breath freshening, controls odor, dental desensibilization, salivary stimulants, whitening agents and their combs�nation. Active materials together with useful substances used in the present invention described in patent document U.S. Patent 6596298 to Leung et al.

Means to prevent the occurrence of Tartar along with useful substances used in the present invention include pyrophosphate salts displacing or tetralone metals, such as Na4P2O7, K4P2O7, Na2K2P2O7, Na2H2P2O7and K2H2P2O7; long chain polyphosphates such as sodium hexametaphosphate and cyclic polyphosphates, such as trimetaphosphate sodium. In some formulations polyphosphate is a β-form of calcium polyphosphate as described in patent document US Patent 6241974 to White, Jr. In some embodiments of the present invention, the film includes means that prevent the formation of stones, about 15 to 20% by weight of the film.

Funds restore aroma of breath used in the present invention is the use of substances precipitating sulphur. Such substances, precipitating sulfur, include metal salts, for example, the copper salt or zinc salt. Such salts include copper gluconate, zinc citrate and zinc gluconate. Zinc salts can be used in combination or in addition to zinc compounds entering� in the film. In various embodiments of the present invention, the film includes substances, precipitating the sulfur level from about 0.01 to about 30% by weight of the film, from about 2% to about 2.5% by weight of the film, or from about 10% to about 20% by weight of the film.

In some embodiments of the present invention, the film and/or oral composition may include salivary stimulator ("succulent"). These stimulants include those substances described in the patent document U.S. Pat. No. 4820506 to Kleinberg et al. In some formulations of the salivary stimulator may include a food acid such as citric, lactic, malic, succinic, ascorbic, fumaric, and tartaric acid. In various embodiments, the film comprises a salivary stimulant level is from about 0.01 to about 12% by weight of the film, from about 1% to about 10% by weight of the film or from about 2.5% to about 6% by weight of the film. In some embodiments of the present invention salivary stimulator can be used to improve the condition of the oral cavity with dry mouth.

In some embodiments, the implementation of care for the oral cavity of the present invention multi-layer film comprises other active materials, such as antibacterial agents: ex�the terrorist attack Magnolia, triclosan, rape seed extract, thymol, methyl salicylate, eucalyptol, menthol, acid hops, cetylpyridinium chloride, (including CPC/Zn and CPC + enzymes) and uninova acid; anti-inflammatory agents, such as substances, refreshing breath (for example, zinc gluconate, zinc citrate, zinc chlorite and alpha ionone); tooth desensibilization, such as potassium nitrate; desensitizing polymers, and desensitizing minerals; anti-inflammatory agents such as Magnolia extract, ursolic acid, aloe and cranberry extract; vitamins such as Pantheon, retinol palmitate, folic acid, tocopherol acetate and vitamin A; herbs or herbal extracts such as rosemary, oregano, chamomile, peppermint, sage or Commiphora and myrrh;

proteins such as milk proteins and enzymes such as the enzymes that produce peroxides, amylase; substances that Deplete plaque in blood vessels, such as papain, glucoamylase, glucose oxidase; and enzymes "next generation"; bleaching agents such as hydrogen peroxide, urea peroxide and phosphate salts; medications, such as aspirin (acetylsalicylic acid), caffeine, and benzocaine; probiotics; abrasives such as silicas (including silicon dioxide of high purity); anticaries substances, such as salts of tin (e.g., tin fluoride) or amino�orig; inhibitors of synthesis of oxide of nitrogen, such as guanidinosuccinic; calcium; anti-adhesive components, such as polivinilbutilovy acid; a safety means, such as Solbrol®(from Bayer Chemicals AG); silicones; compounds of chlorophyll; antileukotriene substances such as beta-carotene; antioxidants, such as vitamin E; and combinations thereof. In some embodiments of the present invention film include such active materials at a concentration of from about 0.01 to about 30% by weight of the film, from about 2% to about 25% by weight of the film or from about 10% to about 20% by weight of the film.

In some embodiments, the present invention multi-layer film and/or a composition for caring for the oral cavity includes a preservative. A preservative can be added in amounts from about 0.001 wt. % to approximately 5 mass. %, preferably approximately from 0.01 masses. % to about 1% by weight of the multilayer film. Non-limiting examples of preservatives include sodium benzoate and potassium sorbate.

The compositions of the present invention include a carrier, in which the introduced multi-layer film or its fragments. As indicated in this document "holder" means any materials or compositions, in which a multilayer film can be �adrena, and should be suitable for administration or application of the person or animal to whom the composition is administered or applied. As mentioned herein, "embedded" refers to the deposition or introduction to the bearer of the multilayer film in the form of suspension. In various embodiments of the present invention contains multiple fragments, such fragments can be introduced by deposition, by introducing in the form of a suspension, dispersion or other distribution of fragments in the media. In various embodiments of the present invention the fragments are distributed largely uniformly throughout the carrier. In other embodiments, implementation of the present invention, the fragments are not evenly distributed in the media. In some embodiments of the present invention the distribution of a plurality of fragments of the multilayer film is essentially uniform inside the media. Composition for cleaning teeth, which include a variety of film fragments dispersed or suspended in a carrier, are commercially available under the trademarks Max Fresh ® or Max White(R), Colgate-Palmolive, New York, N. Y.

Compositions of embodiments of the present invention can be described as consisting of two phases, where one phase comprises a carrier, a second phase consists in�cheepoman film or a fragment. The term "phase" used herein refers to the physical phase, as commonly understood in the physical and natural Sciences, that is, the portion of material whose properties and composition are homogeneous. But the phase, as used herein, may be intermittent, that is, the phase may consist of many individual components. For example, multiple fragments of the polymer film, identical composition, are considered as the inclusion of only one phase. In some embodiments, a fragment of a multilayer film can be completely embedded inside the material containing the first phase, or fully or partially exposed on the surface of the first phase. For example, if the composition is a toothpaste comprising a gel and the fragments of the multilayer film, a film fragment can be completely surrounded by a gel or partially or completely exposed on the surface of the gel. In some embodiments, the present invention compositions comprise more than two phases. Such multiphase compositions encompass those that have two storage media, each of which contributes its own phase in the composition, in addition to fragments of films, as described in the present invention. Other multiphase compositions encompass those that have one carrier and two or more sets of fragments, gdau sets of fragments have different compositions.

In various embodiments of the present invention the medium is in liquid, semi-solid or solid state. The term "fluid" can mean a liquid with low or high viscosity. The fluid can be a liquid that flow in the environment invisible. For example, soap, usually a piece of hand soap, but in this document it can be considered liquid. The fluid may be a thixotropic fluid. The term "semi-solid", as used herein, may be a gel, a colloid, or resin. As used herein, semi-solids and liquids are liquids that vary in viscosity: semi-solid are highly viscous fluid, while the fluid has a low viscosity. There is no exact dividing line between these two types of liquids. Semi-solid may, in some embodiments of the present invention to have a viscosity of up to thousands of MPa·s. Carriers among those used in the present invention include liquids, pastes, ointments and gels, and can be transparent, translucent or opaque.

In some embodiments, the present invention compositions are compositions for the care of the oral cavity and are suitable for introduction into the oral cavity. Such compositions include �the means for brushing your teeth, liquid mouthwash, dental gels, lozenges, balls, chewing gum, mint chewing gum, liquid toothpastes, sprays, dyes, gels, hygienic lipsticks, bleach, fresh breath strips, chewing gum and combinations thereof. Composition for caring for the oral cavity described in the present invention can be used, for example, to prevent caries, whitening, prevent or reduce ulcers, prevent or reduce gingivitis, prevent Tartar, prevent or reduce sensitivity, prevent or reduce odor and prevent staining.

The specific composition of the carrier preferably depends on the intended use of the composition. In various embodiments, the carrier is an aqueous solution comprising from about 5% to about 95% water, or from about 10% to about 70% water. In other embodiments, the media is, basically, not. In the dentifrice in the media water content can be from about 5% to about 70%, from about 10% to about 50% or from about 20% to about 40%. In cases where the presence of water will cause decomposition of the film, especially preferably high�Chenin film did not contain free water, in which the number of the latter is essentially 0%, or negligible.

The media may include any of a variety of materials, including emulsifiers, thickeners, fillers and preservatives. In some embodiments, the carrier may include functional or active material, such as described above. In some embodiments, the implementation of the present invention, the carrier comprises the same functional material as the film.

In one embodiment of the present invention, the carrier is suitable for use as a means for brushing your teeth. In some embodiments, the implementation of the present invention, the carrier comprises a humectant, such as glycerin, sorbitol or allenglish, such as polyethylene glycol or propylene glycol. In some configurations of the present invention, the carrier comprises a humectant at a level from about 10% to about 80% by weight, or from about 20% to about 60% by weight of the composition. Media compositions that are used in the present invention are described in patent documents U. S. Patents 5695746 to Gariick, Jr., et al. and 4839157 to Mei-King Ng et al.

In various embodiments, the manufacture of tools for cleaning teeth media includes thickeners, gelling substances, or combinations thereof. Thickeners or gelatins�interaudio substances as used herein, include inorganic, natural or synthetic thickeners or gelling agents. In some embodiments, the implementation of the present invention, the carrier includes a thickener and gelling substance, which in total comprise from about 0.10% to about 15% by weight or from about 0.4% to about 10% by weight of the composition. Examples of thickeners and gelling substances used in the present invention include inorganic thickening silica, such as amorphous silicon dioxide, for example, Zeodent®165 (from Huber Corporation); Irish moss; iota-carrageenan; gum of tragakant or polyvinylpyrrolidone. In some embodiments, the medium includes a polishing substance, such as silica, calcined alumina, sodium bicarbonate, calcium carbonate, dicalcium phosphate or calcium pyrophosphate. In various embodiments of the present invention the carrier may be visually transparent composition.

In various embodiments, the manufacture of means for brushing the present invention containing a visually transparent carrier, the composition includes at least one polishing agent. Polishing substance used in the present invention includes� colloidal silicon dioxide, for example, such as Zeodent®115 (from Huber Corporation), and aluminosilicate complexes of alkali metals (that is, silica containing alumina). In some formulations of the polishing material may have a refractive index close to that, as the gelling agent in combination with water and/or humidifier. In various embodiments of the present invention, the carrier includes a polishing substance at a level of from about 5% to about 70% by weight of the composition.

In some cleaning of the teeth carrier includes a surfactant or mixture of surfactants. Surfactants among those used in the present invention include water-soluble salt of at least monosulfata monoglyceride one of the most fatty acids, such as sodium salt of monosulfated monoglyceride hydrogenated fatty acids of coconut oil; cocamidopropylbetaine; top alkylsulfate, such as sodium lauryl sulfate; alkylaryl sulfonate, such as dodecylbenzenesulfonate sodium; high alkylsulfonate; sodium'foacetata; ester of higher fatty acid 1,2-dihydroxydiphenylsulfone and mostly saturated higher aliphatic acylamino lower aliphatic aminocarbonyl acid, which has from 2 to 16 carbon atoms in the fatty acid, the alkyl or aryl radicals; and mixtures thereof. Amides may be, for example, N-lauroylsarcosine and sodium, potassium and ethanolamine salts of N-lauroyl-, N-myristoyl - or N-Palmitoyl-sarcosine. In various embodiments, the carrier includes a surfactant level is from about 0.3% to about 5% by weight of the composition, or from about 0.5% to about 3% by weight of the composition.

The present invention also presents methods of making a carrier for the means to care for teeth. In one embodiment of the present invention, water and at least one humectant is dispersed in a conventional mixer to obtain a first homogeneous gel masses. Polishing substance is added to the first homogeneous gel mass. The first homogeneous gel-like mass and a polishing substance are mixed to obtain a second homogeneous gel masses. Thickener, flavor and surfactant added to the second homogeneous gel mass. These components are mixed at high speed under vacuum of approximately 20 to 100 mm Hg. article

The compositions of the present invention are preferably stable under normal storage conditions. As mentioned herein, "stable" indicates no significant negative impact on one, and preferred�flax on all compositional characteristic such as appearance, aroma, rheological properties and chemical composition. Preferably, the stability of the present compositions include compositional and physical stability of multilayer films (including fragments, if any) of the composition. In various embodiments, the composition comprising a multilayer film which is stable when stored at room temperature for at least about two years. It is assumed, however, that in some embodiments, a stable multi-layer film may collapse during use (as described above), e.g., during brushing, the application of means on care of teeth present compositions.

In some embodiments, the present invention composition may include, in addition to the portions of the film, as described herein, two or more media, each of which contributes to the composition. The composition can be resistant to seepage of the dye on the surface of the composition. For example, the composition may include portions of the film and to be striped toothpaste, such as described in patent document US Patent 6315986 to Wong et al. In some embodiments, portions of the film can have a different color (color), rather than the band(s) to improve este�quarter attractiveness.

Composition for cleaning teeth typically includes thickeners that provide the means for brushing your teeth necessary rheological properties to ensure that the dentifrice can be stored in the distribution container for a certain period of time and then be sent securely to the user. The means for cleaning the teeth should preferably be relevant viscosity not only for distribution, but in order to show reasonable consistency within the oral cavity during brushing. Typical thickeners include modified celluloses, such as carboxymethylcellulose (CMC) and other polysaccharides or components of resinous substances.

Polysaccharide thickener may include at least one of xanthan resin and hydroxyethyl cellulose. The polysaccharide thickener is usually composed of xanthan resin, which is present in an amount of from 0.1 to 1.5 wt. % based on the weight of the composition, preferably from 0.5 to 1% by weight of the composition. However, there may be a small number of additional thickener, for example, carrageenan, gum of tragakant, starch, polyvinylpyrrolidone, hydroxyethylmethylcellulose, hydroxyethylmethylcellulose, hydroxypropylmethylcellulose, hydroxyethyl cellulose, carboxymethyl cellulose sodium(sodium CMC) and colloidal silicon dioxide. In one embodiment, the implementation of the concentration of the thickener is in the range from 0.1 wt. % to 5 wt. % based on the weight of the composition. In another embodiment of the present invention the concentration of the thickener is in the range of from 0.5 wt. % to 2 mass. % based on the weight of the composition.

The present invention also provides a method of manufacturing compositions comprising the multilayer film embedded in the media. In various embodiments of the present invention, the multiple fragments of the matrix films are mixed with the carrier. In some embodiments, the present invention can be mixed media and large portions of the multilayer film. In some formulations, the mixture can include slow stirring. In one preferred embodiment of the present invention a method of manufacturing a composition containing media with distributed therein multiple lamellar fragments of multilayer films include:

(a) providing an orally acceptable carrier;

(b) adding lamellar fragments of multi-layer flavored film in an orally acceptable carrier with the formation of the mixture; and

c) homogenization of the mixture.

The term "homogenization" is used herein, refers to the mixing of fragments and native to dost�bending, basically, a homogeneous distribution of fragments in the media. However, it should be noted that the resulting composition still retains the two-phase composition. Homogenization can be accomplished using any of numerous conventional homogenizers.

In another method, a film is added to the component orally acceptable carrier (e.g., to the humidifier for cleaning teeth). Can then make the remaining part of the carrier, to which was added a mixture of film.

Some embodiments of the present invention described herein also are methods of using the oral compositions, including multi-layer films to highlight the flavor regarding a person or an animal. As mentioned in this document, the term "application" refers to any method by which the composition is applied or administered to the subject. In various embodiments of the present invention, the application is local, in which the composition is applied to the outer surface of the object such as the surface of the oral cavity (e.g., teeth, gums, tongue). The specific direction and method of administration, of course, will depend on the intended use of the composition.

In various embodiments of the present invention have the ways PR�changes enhanced flavour, in oral compositions for human or animal in need, including local application of the composition to the multi-layer film for optimal allocation of fragrance, introduced in the media. In one embodiment of the present invention, the method additionally includes the destruction of the multilayer film after local application of oral composition and the multilayer film. Such destruction may be implemented in any number of ways, including chemical and/or mechanical means. Chemical means include the destruction of the multilayer film in contact with water or material present at the site of application (e.g. saliva when used for cleaning teeth). Physical means include extrusion, polishing and friction generated during the use of physical force to the composition during use (for example, the use of toothpaste with a toothbrush when brushing your teeth).

In various embodiments of the present invention are methods of treatment of diseases of the oral cavity. As mentioned herein, "diseases of the oral cavity" is any violation or disease, including business interruption, or disease of the teeth, the mucous membranes of the mouth, gums and tongue, which can be prevented or treated the way� of applying the composition in the oral cavity. Such diseases include dental caries, gingivitis, periodontitis, and cosmetic diseases, such as yellowing and odor.

Embodiments of the present invention described herein can be better understood when referring to the following examples without limiting their application.

The examples and other embodiments of the present invention described herein are exemplary and are not intended to limit the description of the compositions and methods of implementation of the present invention in full. Equivalent changes, amendments or modifications of the particular embodiments, materials, compositions, and methods of implementation can be made within the scope of the present invention, basically, with similar results.

EXAMPLES

Example 1

This example illustrates a three-layer film containing a flavoring in the Central layer, located between two outer surface layers. Each layer of the film comprises hydroxypropyl methylcellulose ("HPMC"), as the film-forming polymer, while in the Central layer contains other fillers, as shown in table 1 below. The Central or core layer also includes a flavoring.

Table 1
ComponentFilm from the suspension solution, mass. %
The surface layer 1
Water83,50
HPMC E512,30

Corn starch2,20
Sweetener Sucralose1,00
Propylene glycol0,60
Tween 800,40
The Central layer 2
Water77,50
HPMC E512,30
Corn starch2,20
Sweetener Sucralose1,00
Propylene glycol0,60
Flavoring6,00
Tween 80 0,40
The surface layer 3
Water83,50
HPMC E512,30
Corn starch2,20
Sweetener Sucralose1,00
Propylene glycol0,60
Tween 800,40

Layer 1 was cast with a thickness of 5 mils and then dried in a drying oven at 95°C for 15 minutes. Layer 2 was cast on top of layer 1 with a thickness of 15 mils and then dried in the same manner. Layer 3 was cast with a thickness of 5 mils and the finished composition is dried at 95°C in the next 15 minutes. The dried film thickness was approximately 2,75 mil scented with a Central layer of 1.65 mils and two surface layers of 0.55 mils each. The film was shredded to pieces using a mill IKA-WERKE (MF 10 basic). Chips ranging in size from 12 to 20 mesh were collected for the manufacture of products, such as toothpaste and liquid mouthwash.

Example 2

This example illustrates how the delayed release of flavor from the multilayer films of the present invention. Mnogosloino� film made, as shown above in example 1, except that the composition of the outer layers 1 and 3 added to the polyvinyl acetate ("PVA"), as shown in table 2 below.

Table 2
The surface layers 1 and 3
ComponentFilm with PVA
Water82,17
HPMC E57,20
HPMC E501,50
Kolicoat 30D (PVA)3,33
Corn starch2,00
Carbopol 971P1,20
TiO20,70
PG1,40
Tween 800,50
Total100,00

The amount of PVA shown in table 2, is sufficient to reduce the rate of swelling of the multilayer films of example 1 and increasing failure times from less than 2 minutes to 3-4 minutes.

Example 3

This example illustrates the technology p�of isgotovlenia toothpaste. Toothpaste A, contains a 3-layer flavored chips obtained as described in example 1. Toothpaste B does not contain any flavored chips, as shown in table 3 below.

Table 3
The name of the componentToothpaste AndToothpaste
Polyethylene glycol 6001,001,00
Sodium CMC - RM0,500,50
Saccharin sodium0,350,35
Sodium fluoride0,320,32
Sorbitol (70% solution)68,0068,00
Purified water9,2710,07
Pigment Blue#150,010,01
Silicon dioxide Zeodent 1148,008,00
Silica Zeodent1658,008,00
Flavoring1,001,00
Cocamidopropylbetaine1,251,25
Sodium lauryl sulfate1,501,50
3-layer flavored chip0,80-
Total100,00100,00

Profile highlight the flavor of toothpaste And containing 3-layer flavored chips, can be traced from the sample of figure 1. Figures 1(a) and 1(b) illustrate the difference between a toothpaste that includes 3-layer flavored chips, and toothpaste B, which does not include them. It is easy to see that A toothpaste intensity profile is higher than toothpaste B. in addition, the signal of the fragrance produced by the flavor extracted from a multilayer chip toothpaste A, provides a more intense signal of the fragrance, which is observed during the cleaning of the teeth after the fragrance foundations toothpaste decreased.

With reference to example 3, tooth PA�those which contains chips 3-layer flavored film that corresponds to the profile of allocation of flavoring figure 1(a). As shown in figure 1 (a), initially, the profile of allocation of flavour toothpaste A, measured on the content of the flavoring in the saliva, was accompanied by the same profile selection of fragrance as a conventional toothpaste B, and as seen in figure 1(b), the content of the flavoring in the saliva amounted to only 1% by mass. After a period of time as soon as the contents of the flavor bases of toothpaste And was spent, stood out the flavor of the chips 3-layer flavored film and the consumer felt a surge of flavor, thanks to the release of 6% by weight of the flavour of the chips 3-layer flavored film that lasted throughout brushing. Splash allocated aroma of 3-layer flavored chips contained in A toothpaste, lasted a long time after the selection of the initial fragrance, thus increasing, the supply of fragrance throughout brushing.

Example 4

This example illustrates the development of formulations of liquid mouthwash. Three-layer flavored chips, made as in example 1, are added to the liquid mouthwash A. Liquid mouthwash B does not contain any chips, as shown in table 4 �others.

Table 4
The name of the componentLiquid mouthwash AndLiquid mouthwash
Purified water70,5170,51
Sorbitol (70% solution)15,0015,00
Glycerin5,005,00
Kelcogel CG-LA0,050,05
Sodium fluoride0,050,05
The disodium hydrogen phosphate (anhydrous)0,050,05
Ethanol6,006,00
Gantez BF 96 (solution)1,501,50
Metalcolour sodium 0,250,25
Mentol Levo0,050,05
Saccharin sodium0,020,02
Triclosan0,30,03
38%-p, NaOH (caustic soda)0,100,10
Chip 3-layer film0,50-
35% sodium Lauryl sulfate0,750,75

Optacool C0,030,03
Flavoring0,100,10
FD&C Red No.400,010,01
Total100,00100,00

Profile selection of flavoring from the liquid for rinsing of A mouth, containing 3-layer chips, repeats the profile of the sample of figure 1(a), the Liquid mouthwash provides A further signal of the flavor and/or more pronounced flavour intensity, while the liquid for rinsing B does not.

Example 5A

This example shows how to manage time signal of the second flavor of toothpaste A. the Multilayer film receive the same as shown above in example 1, except that the thickness of the outer surface layers is increased to 4 mils, which is an effective amount to control the desired second signal from A toothpaste, which is 3-4 minutes, i.e. sufficient time to ensure thorough cleaning of the teeth.

Example 6

This example illustrates how to make toothpaste A, where the signal intensity of the second flavor is under control. In this example, flavored chips from three-layer film prepared in accordance with the method of example 1, except that the amount of flavoring in the primary layer is changed to approximately 40%. The stronger the aroma component of the base layer, the stronger the intensity of the second signal from toothpaste A.

Example 7

This example illustrates how to provide a second signal of a fragrance that differs from the signal of the fragrance foundations of toothpaste. Flavored chips from 3-layer film prepared in accordance with the method of example 1. Flavored chips was then added to toothpaste having the composition of toothpaste A of example 3, for �isklucheniem, what flavor of toothpaste A different flavour from 3-layer flavored chips. When brushing with toothpaste prepared according to this example, the consumer feels the signal of the second aroma and is more intense in comparison with the signal of the first fragrance from the basics of toothpaste. The signal of the second flavor is caused by the release of flavor from the chips 3-layer film follow-up sample, as shown in figure 1.

Example 8

This example illustrates how to prepare a toothpaste that can deliver the signal of a feeling of coolness in addition to the surge of flavor. Chips from 3-layer film prepared as in example 1, except that the flavor, the center layer is complemented by a substance with a feeling of coolness, such as WS-5. Flavored chips containing substance WS-5, then added to a toothpaste having the composition of toothpaste A of example 3. After brushing the consumer experiences a feeling of coolness in addition to the scent of toothpaste and A flavor, present in 3-layer chips in it.

Example 9

This example shows how to prepare a toothpaste that can deliver the signal of a tingling sensation in addition to splash of flavor. Chips from 3-layer film prepared as in example 1, except tog�, what flavor, the center layer is complemented by a substance with a tingling sensation, like spilanthol. Flavored chips containing spilanthol, then added to a toothpaste having the composition of toothpaste A of example 3. After brushing a consumer experiences a tingling sensation in addition to the scent of toothpaste and A flavor, present in 3-layer chips in it.

Example 10

This example illustrates how to prepare a toothpaste that can deliver the signal the sensation of sweetness in addition to splash of flavor. Chips from 3-layer film prepared as in example 1, except that the flavor, the center layer is complemented by a substance with a sense of sweetness, such as Sucralose. Flavored chips, also containing a substance with a sense of sweetness, then added to a toothpaste having the composition of toothpaste A of example 3. After brushing, the user experiences the sensation of sweetness in addition to the scent of toothpaste and A flavor, present in 3-layer chips in it.

Example 11

This example shows how to prepare a toothpaste that can deliver the signal feelings of warmth in addition to a surge in the aroma. Chips from 3-layer film prepared as in example 1, except that the flavoring Central�layer is complemented by a substance with a sense of warmth, such as water activated zeolites. Flavored chips, also containing a substance with a sense of warmth, then added to a toothpaste having the composition of toothpaste A of example 3. After cleaning, the Central layer is exposed to water from the saliva, resulting in the user experiences the sensation of warmth in addition to the scent of toothpaste and A flavor, present in 3-layer chips in it.

1. Composition for caring for the oral cavity, with an increased allocation of flavor, containing:
orally acceptable carrier containing a first flavor;
the multilayer film comprising a Central layer between two outer surface layers, where at least one of the outer surface layer further comprises a substance modulating the secretion, representing a polyvinyl acetate or hydroxyethyl cellulose; and
where specified Central layer contains a second flavor, where the allocation of the second flavour is delayed for the period from 1 to 5 minutes.

2. A composition according to claim 1, in which each layer includes a film-forming polymer.

3. A composition according to claim 2, in which the film-forming polymer selected from hydroxypropylmethylcellulose, methylcellulose, hydroxypropyl cellulose and mixtures of polymers.

4. A composition according to claim 2, � which the content of film-forming polymer is from about 25% to about 75% by weight of the multilayer film.

5. A composition according to claim 1, in which the number of substances modulating the secretion, is from about 5% to about 30% by weight of the multilayer film.

6. A composition according to claim 1, in which an orally acceptable carrier is a dentifrice or a liquid mouthwash.

7. A composition according to claim 1, in which the thickness of each outer surface layer is about 0.1 mil to about 4 mils.

8. A composition according to claim 7, in which the thickness of each outer surface layer is approximately 0.3 mils to approximately 0.75 mils.

9. A composition according to claim 1, in which the specified second flavor is from about 1% to about 60% by weight of the specified Central layer.

10. A composition according to claim 9, in which the specified second flavor is from about 5% to about 40% by weight of the specified Central layer.

11. A composition according to claim 10, in which the specified second flavor is from about 10% to about 25% by weight of the specified Central layer.

12. A composition according to claim 1, wherein the Central layer further comprises one or more substance selected from the group containing a substance with a feeling of coolness, a tingling sensation, a sense of sweetness, the feeling of warmth and a mixture of two or more of them.

13. �omposite according to claim 12, in which a substance that simulates the feeling of coolness selected from the group comprising menthol, N-ethyl-p-Mentana-3-carboxamide, ethyl-3-(p-Mentana-3-carboxamide) acetate, 2-isopropyl-N, 2,3-dimethylbutyramide and L-Mantellate.

14. A composition according to claim 12, in which a substance that simulates the sensation of tingling, selected from the group consisting of spilanthol, capsaicin and oleoresin capsicum.

15. A composition according to claim 12, in which the substance of the signal sweets selected from the group that includes saccharin sodium, energy, aspartame, neotame, and Acesulfame-K.

16. A composition according to claim 12, in which a substance that simulates the sensation of heat selected from the group consisting of cinnamic aldehyde, zeolites and capsaicin.

17. A composition according to claim 1, in which the specified first flavor and the second flavor are the same.

18. A composition according to claim 1, in which the specified first flavor and the second flavor are different.

19. A composition according to claim 1, in which the specified first flavor is allocated from the specified carrier at a speed effective for delivery of the specified first flavor to the oral cavity for approximately 1 second to approximately 30 seconds after contact of the composition with the surface of the oral cavity.

20. A composition according to claim 1, in which the specified second flavor is released from the Central cloaca speed effective for delivery of the specified second flavor to the oral cavity for from about 30 seconds to about 60 seconds after contact of the composition with the surface of the oral cavity.

21. A composition according to claim 1, in which the specified second flavor is released from the specified Central layer with a velocity effective for delivery of the specified second flavor to the surface of the oral cavity for from about 1 second to about 120 seconds after contact of the composition with the surface of the oral cavity.

22. A composition according to claim 1, in which the specified multi-layer film further comprises additional layers of film.



 

Same patents:

FIELD: medicine.

SUBSTANCE: vaseline-lanolin (2:1) based ointment 74.0 g is added with a 40% herbal alcoholate 25 ml of the following composition (in the mixture of a herbal raw material: alcohol base - 1:5), weight fractions: nodding catchfly herb - 3 weight fractions, pot marigold blossom - 1 weight fraction, spiraea herb - 1 weight fraction, with the ointment added with clove oil 1.0 ml. The prepared ointment is applied on inflamed periodontal and oral mucosal tissues for 20 minutes 2-3 times a day for 14 days; the patient is advised not to drink or eat for 1 hour.

EFFECT: method enables increasing clinical effectiveness by combining high antimicrobial, immunomodulatory, anti-allergic and keratoplastic activity and ease of use.

3 ex

FIELD: medicine.

SUBSTANCE: on completion of the antibacterial course, sodium hyaluronate in the form of a gel is single administered by means of a syringe with a needle of 2 cm long or more under an oral mucosa along a transitory fold into the points within projections of apexes of dental roots 1.4, 2.4, 3.6, 4.6 and into a point on the mid-line of projections of apexes of anterior roots of upper and lower jaw respectively. The needle is brought under the mucosa on the lower jaw by transecting the projections of an alveolar counterfort line. On the upper jaw - by transecting the projections of the upper counterfort line. While removing the needle from the mucosa, the syringe content is squeezed out. Sodium hyaluronate is administered into both jaws in an amount of 3.0 to 4.4 ml.

EFFECT: method enables increasing the jaw bone density within counterforts, as well as soft and bone tissues of periodontium.

4 tbl, 16 dwg, 3 ex

FIELD: medicine.

SUBSTANCE: invention refers to dentistry and concerns treating chronic generalised periodontitis. Implementing the above method is ensured by a complex preparation in the form of an ointment of the following composition: Vaselin - lanolin base (1:1) - 88.5 g, 70% ipecac infusion - 5.0 g, 70% scholar tree - 5.0 g, Ecdysterone - 0.02 g; eucalyptus oil - 1.0 g. The oil is applied as a therapeutic periodontal applicate on a gingival surface following application anaesthesia with 10% lidocaine, chairside oral hygiene, drug-induced treatment of the gingival margin with 1% Iodinolum and separation of salivary glands in the oral cavity, once a day for 2 hours for 4 weeks; the patients are recommended not to eat or drink for two hours. The preparation composition particularly provides capillary-reinforcing, anti-inflammatory, reparative and anaesthetic action.

EFFECT: method of treating is easy to use, physiologically-friendly, and provides the complete recovery.

2 ex

FIELD: chemistry.

SUBSTANCE: invention relates to a compound of formula (I) : or a salt thereof, wherein R1 and R5 are independently selected from H, OH and alkoxy; R2-R4 and R6-R8 are independently selected from H, OH, F, Cl, Br and I; R9 and R10 are C2-C8 alkenyl; under the condition that at least one of R1, R5 and R7 is OH or alkoxy; at least one of R2-R4, R6 and R8 is F, Cl, Br or I; and R2 and R6 are Cl. The invention also relates to an antibacterial composition and treatment methods.

EFFECT: improved properties.

18 cl, 7 ex, 10 tbl

FIELD: medicine.

SUBSTANCE: agent for treating inflammatory periodontal and oral mucosal diseases associated with Helicobacter infection contains silicone glycerohydrogel of Si(C3H7O3)4·6C3H8O3·24H2O and bismuthate tripotassium dicitrate of formula [HOC(CH2COO)2COO]2K3Bi in the following proportions, wt %: bismuthate tripotassium dicitrate 1.0-2.5; silicone glycerohydrogel - the rest up to 100. The method of treating inflammatory periodontal and oral mucosal diseases consists in a combination of systemic standard anti-Helicobacter therapy and a local effect of the above agent on the involved region. Particularly, treating periodontitis is ensured by applying the agent on the gingival surface and introducing it into the gingival pockets once a day for 10 min; the therapeutic course makes 5-6 days. The oral mucosal diseases are treated by applying the agent 0.1 mm thick with a glass spatula on the involved oral mucosa 2 times a day; the therapeutic course is 12 days.

EFFECT: formulation of the agent provides achieving the high therapeutic effect; the dosage form is easy to be applied locally.

4 cl, 2 dwg, 1 tbl, 2 ex

FIELD: medicine.

SUBSTANCE: method includes the preparation of a carious cavity, opening the tooth cavity, creation of an access to root canals, extension of their orifice. Removal of a decayed material from the root canals and their drug treatment are carried out. After that, performed are: wide opening of the apical tooth orifice, mechanical and drug removal of periapical pathological exudative formations in the focus of periapical inflammation through the root canal. Before filling the canal with a filling material the gel "Lamifaren" is introduced into the focus of periapical destruction. Such introduction is performed three times after a day under temporary stopping. The gel "Lamifaren" is introduced inside in a dose of 50 g 2 times per day for 30 days.

EFFECT: application of the invention accelerates bone tissue regeneration due to the active release of an active substance calcium alginate, provides stable remission due to local and systemic detoxifying effect.

2 ex

FIELD: medicine.

SUBSTANCE: treatment is two-staged; at the first stage, gingival pockets are rinsed with a stream of 1.5% hydrogen peroxide in a cannula delivered through the gingival pockets around the teeth. If observing the exposed furcation of premolars and molars, the cannula is brought under the root furcation. Thereafter, the gingival pockets are similarly rinsed with an aqueous tincture of garden sage herb for 3-5 days, then with an aqueous tincture of camomile blossom for 3-5 days, an aqueous tincture of plantain leaves daily for the following 3-5 days; each rinsing procedure is followed by applications of cotton drains impregnated with the respective aqueous herbal tincture introduced by the cannula on gingival mucous membranes for 1 hour; that is combined with prescribing oral baths with the respective aqueous herbal tincture introduced by the cannula daily 5-7 times a day. The second stage involves instillations of Normoflorin-B or Bifidumbacterin in the cannula delivered through the gingival pockets around the teeth, brought under the furcation if observing the exposed furcation of premolars and molars; the gingival mucous membranes are laid with cotton drains with the above preparation for 2 hours daily for 5-10 days.

EFFECT: method enables providing the higher clinical effectiveness.

2 cl, 1 ex

FIELD: medicine.

SUBSTANCE: at the first stage, after removing supra- and sub-gingival dental calculus and granulations, cleaning the teeth professionally, rinsing gingival pockets by stream infusions of 1.5% hydrogen peroxide in a cannula delivered through the gingival pockets around the teeth, brought under root furcation if observing the exposed furcation of premolars and molars; the preparation "Calsept" is administered within the frontal teeth for 5-7 days daily into the gingival pockets bringing the cannula similarly around the teeth, whereas the preparation "Calsept-Iodo" is administered within the distal teeth; the dentist recommends that the patient does not eat for 2 hours thereafter. The second stage involves administering a preparation containing bifidus bacteria, e.g. Normoflorin-B or Bifidumbacterin by instillations in a cannula delivered through the gingival pockets around the teeth, brought under the furcation if observing the exposed furcation of premolars and molars; gingival mucous membranes are laid with cotton drains with the preparation for 2 hours daily for 5-10 days.

EFFECT: using the method provides increasing the therapeutic effect ensured by the antibacterial effect, odontotropic and anaesthetic action, bone tissue recovery, action of the therapeutic preparation in difficult-to-access anatomic formations.

2 cl, 1 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to health-promoting compositions and methods for preparing them. A method for preparing the composition of non-living lactic acid bacilli, possessing an ability of specific binding to Streptococcus mutans, involves the following stages: heating a cell suspension of lactic acid bacillus or a mixture of lactic acid bacilli possessing an ability of specific binding to Streptococcus mutans from an initial temperature of less than 40°C to a pasteurisation temperature of 75 to 85°C with a temperature variation within the range of 0.5 to 2°C/min, keeping the heated suspension at a pasteurisation temperature of 20 to 40 minutes and cooling the suspension to a final temperature of less than 40°C within the range of 0.5 to 2°C/min. The specific binding the cell suspension of the lactic acid bacillus or the mixture of lactic acid bacilli to Streptococcus mutans is stable to heat treatment and/or resistant to proteases and/or calcium-dependent and/or is observed within the range of pH values falling within the range of 4.5 and 8.5, and/or in the saliva environment.

EFFECT: invention enables producing the agent preventing or delaying the caries lesion formation.

9 cl, 4 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: group of inventions refers to oral care compositions containing a basic amino acid or its salt. The presented oral care composition promoting the dentine defect closure in the oral cavity contains arginine in the free form or in the form of a salt, and an abrasive substance representing synthetic amorphous silica and containing small particle fractures making at least approximately 5% of total weight of the composition, wherein the particles of the small particle fracture having d50 from 3 to 4 mcm. What is also presented is a method of treating sensitive teeth in the oral cavity involving using the oral treatment with this composition, as well as using arginine as a part of the oral care composition and for producing a therapeutic agent, wherein the above composition and agent contain the above abrasive material containing the small particle fracture.

EFFECT: group of inventions provide the effective dentin defect closure in the patient's oral cavity.

8 cl, 1 tbl, 6 ex

FIELD: medicine.

SUBSTANCE: vaseline-lanolin (2:1) based ointment 74.0 g is added with a 40% herbal alcoholate 25 ml of the following composition (in the mixture of a herbal raw material: alcohol base - 1:5), weight fractions: nodding catchfly herb - 3 weight fractions, pot marigold blossom - 1 weight fraction, spiraea herb - 1 weight fraction, with the ointment added with clove oil 1.0 ml. The prepared ointment is applied on inflamed periodontal and oral mucosal tissues for 20 minutes 2-3 times a day for 14 days; the patient is advised not to drink or eat for 1 hour.

EFFECT: method enables increasing clinical effectiveness by combining high antimicrobial, immunomodulatory, anti-allergic and keratoplastic activity and ease of use.

3 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: present invention refers to a compound of formula such as below , wherein Z is oxygen; Y is hydrogen or a sequence as follows: -O-C(R4)-V-(C=O)-R5; V is oxygen; R1 and R4 are identically or independently hydrogen or a C1-4 alkyl; R2 and R5 are identically or independently a C1-10 alkyl.

EFFECT: these compounds can be applicable in therapy for treating pathologies or disorders related to the presence of Propionibacterium acnes, eg acne-like skin disorders.

5 cl, 2 tbl, 2 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: claimed is emulsified composition for improvement of skin condition, which contains (A) 0.001-10 wt % of organic compound, which has two or more hydroxyl groups, inorganic value 220-450 and organic value 300-1000; (B) 0.001-10 wt % of organic compound, which has one hydroxyl group, inorganic value 100-200 and organic value 280-700; (C) 0.001-10 wt % of organic substance, represented by formula (2), in which R1 is C4-C30 hydrocarbon group; Z is methylene group, methane group or oxygen atom; X1, X2, X3 are hydrogen atom, hydroxyl group or acetoxy group; X4 is hydrogen atom, acetyl group or glyceryl group; each of R2 and R3 is hydrogen atom, hydroxyl group, hydroxymethyl group or acetoxymethyl group; R4 is C5-C60 hydrocarbon group; and R5 is hydrogen atom or hydrocarbon group, containing in total 1-30 carbon atoms; (D) (D) 0.00012-10 wt % of at least one compound, selected from group, consisting of non-ionic surface-active substance, which has polyoxyethylene group and HLB 10 or higher, ionic surface-active substance and sphingosine salt; (E) 0.003-15 wt % of at least one compound, selected from group, consisting of sugar alcohol, selected from group, consisting of erythritol, threitol, xylitol and mannitol, disaccharide and trisaccaride, and (F) water.

EFFECT: emulsion composition preserves water in skin for long time.

13 cl, 1 dwg, 18 tbl, 64 ex

FIELD: chemistry.

SUBSTANCE: present invention refers to developing brewing products. According to the invention, a method for preparing an extract of polyphenols as a result of brewage involves the stages: contacting partially purified beer with resin, which adsorbs polyphenols; desorbing polyphenols adsorbed on the resin contacting with partially purified beer; adsorbing polyphenols on the second resin different from the first one; the above second resin is hydrophobic and non-ionic; and desorbing polyphenols adsorbed on the second resin with using an organic solvent; implementing the method is ethylacetate-free. The invention also refers to the method for preparing the extract of polyphenols as a result of brewage that involves the following stages: contacting partially purified beer with hydrophobic and non-ionic resin, which adsorbs polyphenols; and desorbing polyphenols adsorbed on the resin used at the previous stage of contacting with using the organic solvent; a desorption product contains at least 0.85 g of polyphenols per one gram of a dry matter. The invention also refers to the extract of polyphenols prepared by the above method and containing catechin, epicatechin, thyrozol and ferulic acid. The invention also refers to a cosmetic product, a functional food product, a food additive, which contain the above extract of polyphenols in an effective amount. Also the invention provides using the above cosmetic product for skin moistening and/or ageing prevention or delay, using the extract of polyphenols for producing an antioxidant composition.

EFFECT: invention provides preparing the extract of ethylacetate-free and high-purity polyphenols.

19 cl, 23 dwg, 22 tbl, 6 ex

FIELD: medicine.

SUBSTANCE: invention refers to dentistry and concerns treating chronic generalised periodontitis. Implementing the above method is ensured by a complex preparation in the form of an ointment of the following composition: Vaselin - lanolin base (1:1) - 88.5 g, 70% ipecac infusion - 5.0 g, 70% scholar tree - 5.0 g, Ecdysterone - 0.02 g; eucalyptus oil - 1.0 g. The oil is applied as a therapeutic periodontal applicate on a gingival surface following application anaesthesia with 10% lidocaine, chairside oral hygiene, drug-induced treatment of the gingival margin with 1% Iodinolum and separation of salivary glands in the oral cavity, once a day for 2 hours for 4 weeks; the patients are recommended not to eat or drink for two hours. The preparation composition particularly provides capillary-reinforcing, anti-inflammatory, reparative and anaesthetic action.

EFFECT: method of treating is easy to use, physiologically-friendly, and provides the complete recovery.

2 ex

FIELD: medicine.

SUBSTANCE: method of treating chronic generalised periodontitis includes the influence on an affected area by the therapeutic diode laser "HELBO" 2075 F/Theralite" with photosensitase "HELBO Blue Photosensitizer", with the application after the laser influence on the periodontium affected area of an adhesive gingival bandage, to prepare which the antioxidant "Melaxen", kalanchoe sap, glycosamine hydrochloride, dimethylsulphoxide, water dentine and solcoseryl dental adhesive paste are applied in specified quantities.

EFFECT: achievement of an anti-inflammatory, antiseptic and reparative effect, which makes it possible to stop inflammation in the tissues of periodontium and obtain stable long-lasting remission.

1 tbl, 2 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to pharmaceutical industry, namely to means, possessive immunomodulating action. Method of human immunomodulation by application of live suspension of chlorella of strain Chlorella vulgaris IGF No C-111 with concentration 8-10 millions cell/ml in quantity 200 ml per day for adult human.

EFFECT: method makes it possible to increase human immunity effectively.

7 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to the pharmaceutical industry, namely to a method of obtaining pectins from a biomass of cultured tissues of plants Silene vulgaris (M.) G. The method of obtaining pectins with an increased content of galactose residues in side carbon chains from Calusa cultures includes raw material destruction, extraction with water, processing of the biomass with hydrochloric acid, water washing, extraction with ammonium oxalate solution, sedimentation of polysaccharide with ethanol, dialysis and lyophilising, with Caluse cultures being preliminarily grown for 21 hours on an agarised nutrient medium, which contains the ferment 1,4-β-D-galactozyltranspherase in a specified concentration, and as the raw material the biomass of cultured tissues of plants Silene vulgaris is applied.

EFFECT: method makes it possible to obtain physiologically active pectins, which have a specified structure and stable chemical composition.

1 tbl, 4 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: group of inventions refers to an oral care composition, methods for preparing and using it. The presented composition containing a pre-mix containing arginine in the free form or in the form of a salt, a soluble carbonate salt and arginine bicarbonate formed in situ when mixing arginine in the free form or in the form of a salt with the soluble carbonate salt. The method for preparing the composition involves preparing the pre-mix by mixing arginine in the free form or in the form of the salt and soluble carbonate salt. What is also presented is an oral care procedure involving coating the patient's oral cavity with an effective amount of the above composition.

EFFECT: using the group of inventions provides positive effects achieved by using the oral care composition containing arginine bicarbonate in a combination with a simplified process of preparation of this composition.

15 cl, 2 ex

FIELD: chemistry.

SUBSTANCE: invention relates to method of obtaining rosemary microcapsules. Claimed method is characterised by the fact that mixture of rosemary and dimethylsulphoxide is dispersed in suspension of carrageenan in ethanol in presence of preparation E472c, with the following addition of toluene and water, obtained suspension of microcapsules is filtered and dried, with ratio core/envelope in microcapsules constituting 1:1 or 1:3.

EFFECT: method by invention ensures simplification and acceleration of process of obtaining microcapsules, as well as increase of output by weight.

2 ex

FIELD: medicine, oncology, amino acids.

SUBSTANCE: invention relates, in particular, to the development of an antitumor preparation based on natural substances. Invention relates to an amino acid preparation comprising at least one modified essential amino acid obtained by treatment of amino acid by ultraviolet radiation (UV) at wavelength 250-350 nm for 12-80 h at temperature 15-30oC or with ozone at temperature 15-25oC. The modified amino acid has no toxicity for health cells. Also, invention relates to a method for preparing such preparation. Invention provides the development of an antitumor preparation based on modified amino acids and expanded assortment of antitumor preparations being without cytotoxicity for normal cells.

EFFECT: valuable medicinal antitumor properties of preparation.

8 cl, 4 tbl, 2 dwg, 4 ex

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