Method of treating inflammatory periodontal and oral mucosal diseases
SUBSTANCE: vaseline-lanolin (2:1) based ointment 74.0 g is added with a 40% herbal alcoholate 25 ml of the following composition (in the mixture of a herbal raw material: alcohol base - 1:5), weight fractions: nodding catchfly herb - 3 weight fractions, pot marigold blossom - 1 weight fraction, spiraea herb - 1 weight fraction, with the ointment added with clove oil 1.0 ml. The prepared ointment is applied on inflamed periodontal and oral mucosal tissues for 20 minutes 2-3 times a day for 14 days; the patient is advised not to drink or eat for 1 hour.
EFFECT: method enables increasing clinical effectiveness by combining high antimicrobial, immunomodulatory, anti-allergic and keratoplastic activity and ease of use.
The invention relates to medicine, namely to dentistry, and relates to the treatment of inflammatory diseases of periodontium and mucous membranes of the mouth, which is one of the urgent problems of modern dentistry.
According to the latest studies, the periodontal diseases are widely spread among the population. Early signs of periodontal disease of an inflammatory nature are recorded in age from 10 to 20 years, 80% of the population suffer from gingivitis. Marked destructive changes in the periodontium with involvement of the bone is most frequently detected in persons older than 40 years.
According to the analysis of who data, collected in 35 countries among those aged 31-44 years, 7 countries have seen very high (over 75%), in 13 countries - high (40-75%) and in 15 countries with moderate (less than 40%) prevalence of periodontal disease.
Inflammatory periodontal disease may develop under the influence of local causes and combined effects of local and General factors on the background of altered reactivity of the organism. The Genesis of these pathologies is due to plaque and histologically proceeds in four phases. On Page and Scroder distinguish initial, early, open, and progressive lesions. The initial and early lesion clinically manifested acute gingivitis, an open lesion - chronic� gingivitis. Progressive lesion represents a shift from chronic gingivitis to periodontitis.
Etiological role of microbial plaque in the occurrence of gingivitis proven by clinical observation and experiment. The effect of microorganisms on the periodontium of the two-phase, wherein the first phase is responsible for adhesion of bacteria to periodontal tissues and colonization of the gingival sulcus; in the second phase observed infestation of bacteria in periodontal tissues.
Local inflammatory risk factors of periodontal disease include abnormalities and deformities of the jaws, malnutrition and crowding of the teeth, malocclusion, abnormalities of the soft tissues of the oral cavity, shallow vestibule of the mouth, pronounced bands of mucous membrane, abnormalities of the attachment of the frenulum of the lips, tongue, etc. the common factors that reduce the resistance of the body and creates a predisposition to periodontal disease, it should be noted endocrine diseases, neuro-somatic diseases, blood disorders, eating disorders, gastro-intestinal tract.
Conservative treatment of inflammatory periodontal diseases is to eliminate local irritants, clinical symptoms, pathogenetically effects on dystrophic-inflammatory process in periodontal tissues, simulationist regenerative processes recommendations for rational oral health.
Currently, local drug therapy aimed at elimination of gingivitis and improve regeneration, reduction of periodontal pockets. For this purpose, use drugs of different groups, such as antiseptics, antibiotics, herbal remedies, non-steroid anti-inflammatory drugs, sclerosing drugs, enzymes, hormones, vitamins. However, most drugs are the drugs of synthetic origin and can cause unwanted side effects, allergic reactions, reduced efficiency in the presence of exudate from the periodontal pocket. Our goal was to develop a ointment which has anti-inflammatory, immunomodulatory and keratoplastic action, easy to manufacture and does not cause allergic reactions with prolonged use.
Pathology of the mucous membrane of the oral cavity of a person can be caused by a malfunction of the internal organs and systems, the action of pathogenic microorganisms and viruses or external traumatic factors.
According to different authors, the prevalence of diseases of the mucosa of the oral cavity ranges from 3-5% to 8-20%. So far, for many diseases the importance of symptomatic treatment, t�to as not enough is known about their etiology and pathogenesis. An important principle of treating all patients remains a complex approach with the use of local and overall impact. Local therapy includes the removal of all local traumatic factors, pain management, prevention of secondary infection of the lesion, increased regeneration and epithelialization, stimulation of the immune factors of protection of the oral cavity. General treatment includes consultations with General practitioners, the purpose of the funds the overall impact.
Benign inflammatory disease of the mucosa, the red border of the lips and surrounding skin include hejlitov. Lip diseases often accompany the pathology of the gastrointestinal tract, neuroendocrine system, immunodeficiency, etc. Important role in the development of the disease belongs to adverse conditions in the oral cavity, such as high contamination by microorganisms maceration saliva, bad habits, trauma to teeth, as well as the effect excessively dry and frosty air.
Lip diseases are characterized by a persistent course, difficult to treat. Patients most often complain of dryness, burning and peeling of the lips, in certain types of cheilitis may appear small painful blisters, sores and cracks. Treatment hejlitov is limited to the exclusion of the identified allergens (thickets� food), the purpose of the diet with the exception of spicy, salty and spicy food, the use of non-specific desensitizing therapy, the use of homeopathic medicines, treatment of identified comorbidities. Is learning rational oral hygiene, treatment of carious teeth, the appointment of glucocorticoid ointments, proteolytic enzymes, antiseptics in the area of the lesions.
To diseases of the mucous shell mouth also include chronic recurrent aphthous stomatitis, which is defined as the disease is infectious-allergic nature, the development of which is important bacterial factor (tonsillitis, sinusitis, otitis media, gastro-intestinal tract, periodontitis). Mechanical injury of the mucous membrane of the oral cavity contribute to the emergence of the AFL, while over time more frequent relapses. Single painful aphthae appear on the unaltered mucous membrane of the lips, cheeks, transition the crease of the vestibule of the mouth, tongue.
Local treatment of chronic recurrent aphthous stomatitis helps to eliminate the influence of secondary microflora and includes anesthesia, antiseptic treatment, epithelizing therapy and physiotherapy. To provide anti-inflammatory and wound-healing effect, we offered �of ASI, possessing these properties due to the ingredients included in its composition.
The technical result - improving the efficiency of treatment of inflammatory periodontal diseases and the mucous membranes of the oral cavity when using the claimed ointment which combines high antimicrobial, immunomodulatory, anti-allergic and keratoplastic activity.
The task is implemented with the medicinal drug which is an ointment prepared according to the following technology: in a porcelain Cup make 74,0 g ointment base consisting of 2 parts of vaseline and 1 part of anhydrous lanolin, which add 25 ml of 40% alcohol tincture from the plant collection of the following composition (the combination of plant material: solvent-base - 1:5), wt.h.: grass Campion drooping - 3 wt.h., the flowers of calendula drug - 1 wt.h., grass meadowsweet šestilepestnyj - 1 wt.h. The mixture was carefully emulsiable before reception of homogeneous weight, and then added with stirring 1.0 ml of clove oil. An ointment is a homogeneous Macy light yellow color with a faint clove odor.
Grass Campion drooping has anti-inflammatory, analgesic, haemostatic and anti-toxic effect, contains phytoecdysteroids. Calendula flowers are known for their medicinal� antiseptic properties. Drugs produced using grass meadowsweet šestilepestnyj, have antibacterial, astringent, bactericidal and capillary action. Clove oil, which is part of an ointment, a potent antiseptic and analgesic properties.
The parameters of the components included in the composition of the proposed drug was determined empirically. The specified ranges of concentrations of active substances are optimally acceptable and farmacologicas significant.
Shelf life ointment - 3 months. Settings ointments stable during storage.
Clinical studies of the proposed method of treatment of inflammatory periodontal diseases and the mucous membranes of the oral cavity was carried out at the Department of therapeutic and pediatric stomatology sbei HPE Ryazgmu Ministry of health of Russia. This purpose was carried out for the treatment of 24 patients aged from 35 to 70 years with inflammatory periodontal diseases, 11 (46%) men and 13 (54%) women; 28 patients aged 12 to 65 years with diseases of the mucous membranes of the oral cavity, of which 16 (57%) males and 12 (43%) women.
Treatment of inflammatory periodontal diseases with the use of the claimed ointment was conducted by the following method: performed by a professional hygiene of the oral cavity, was used for the insulation of the ducts of the salivary glands in the oral cavity, was performed�camping application of the ointment in the affected gums and periodontal pockets for 20 minutes. The patients were advised within one hour to refrain from taking food and water. The course of treatment was 14 days, the procedure was carried out 2-3 times a day.
Treatment of diseases of the mucous membranes of the oral cavity with the use of the claimed ointment was carried out according to the following procedure: treatment of infected mucosa and the vermilion border with a swab moistened with 1% solution of hydrogen peroxide, the removal of pathological elements and crusts, applying to the affected area ointments mentioned composition for 20 minutes. The patients were advised within one hour to refrain from taking food and water. The course of treatment was 14 days, the procedure was carried out 2-3 times a day.
15.09.2013 I visit. Patient A., 55 years old, came to the Department of therapeutic and pediatric stomatology sbei HPE Ryazgmu of the Ministry of health with complaints of bleeding gums when brushing your teeth and while eating; itching in the gums; loosening of teeth; bad breath.
Medical history: complaints of this nature, the patient was observed for 10 months.
The anamnesis of life: the patient suffers from chronic pyelonephritis for 14 years.
Objectively: the gums in the area of teeth upper and lower jaw swollen, hyperemic, bleeds on probing. The hygienic condition of the mouth is unsatisfactory, there is a large number of l�the degree of soft plaque and hard dental deposits, the hygiene index Green-Vermillion (GAMES, OHI-S) was 2.0, which corresponds to the unsatisfactory level of hygiene. Index PMA (papillare-marginal-alveolar index) was 65.3 per cent (inflammation of the marginal gingiva and alveolar); periodontal index (PI, Russel) was 2.4, which corresponds to medium to severe degree of pathology of the periodontium. On the radiograph is determined by the bone resorption of interdental partitions to1/2; periodontal pocket depth is 4-5 mm; abnormal mobility of the II degree.
Diagnosis: generalized periodontitis of moderate severity (chronicity.
Treatment: removal of above - and subgingival dental plaque by ultrasound, polishing the necks of the teeth with a toothpaste that contains no fluoride, pocketing a solution of 0.05% chlorhexidine, the application on the gums and periodontal pockets of the claimed ointment for 20 minutes 2-3 times a day for 14 days.
29.09.2013 G. II visit. Complaints: the patient noted significant improvement: the disappearance of bleeding gums when brushing your teeth and eating; reducing itching of the gums; a lack of mobility of teeth.
Medical history: the patient continues treatment for chronic generalized moderate periodontitis.
Objectively: the gums in the area of teeth upper and lower jaw slightly hyperemic,moderately moist, don't bleed on probing. The hygiene index Green-Vermillion (GAMES, OHI-S) was 1.33, which corresponds to a satisfactory level of hygiene. Index PMA (papillare-marginal-alveolar index) was 23.1% - mild degree of inflammation; periodontal index (PI, Russel) was 0.9, which corresponds to a mild degree of periodontal diseases; abnormal mobility is absent.
After 6 months (16.03.2014) after the start of treatment there were no complaints.
Objectively: the gums in the area of teeth upper and lower jaw pink, moderately moist, not bleed on probing. The hygiene index Green-Vermillion (GAMES, OHI-S) was 1.22, which corresponds to a satisfactory level of hygiene. Index PMA (papillare-marginal-alveolar index) 21.7% - mild degree of inflammation; periodontal index (PI, Russel) was 0.8, which corresponds to a mild degree of periodontal diseases; abnormal mobility is absent.
10.10.2013 I visit. Patient M., age 16, turned to the Department of therapeutic and pediatric stomatology sbei HPE Ryazgmu of the Ministry of health with complaints of dryness and itching of the lips; limited due to pain opening the mouth; the aesthetic disadvantage; pain when talking, eating; feeling of tightness in the corners of the mouth.
The anamnesis of disease: according to his mother, the disease appeared �first at the age of 9 years. He was treated at the dermatologist, used various ointments while achieving only temporary improvement. With age there is a progression of the disease.
Life history: the patient has an Allergy to citrus and caviar; bad habits - licks and bites his lips, scratching at the corners of the mouth. Suffers from chronic gastritis for 3 years.
Objective: regional lymph nodes are not palpable, the red border of the upper and lower lips dry, covered with small scales. On the lips and in the corners of the mouth are detected small cracks, which pass on the skin. Skin within a radius of 2.5 cm around the mouth affected lichenization, pigmented. Noted the abundance of above - and subgingival dental plaque, oral hygiene index Green-Vermillion (GAMES, OHI-S) was 2.33, which corresponds to the unsatisfactory level of hygiene. Diagnosis: atopic cheilitis.
Treatment: removal of above - and subgingival dental plaque by ultrasound, polishing the necks of the teeth with a toothpaste that contains no fluoride, treatment of the red border of lips and perioral area with a swab moistened with 1% solution of hydrogen peroxide, carried out the laundering from the crusts, and then to the affected area you applied the cream mentioned composition for 20 minutes. The patient was advised for one hour to refrain from taking food and water. The course of treatment was 14 days, the procedure was carried out 2-3 times in den�. Starting with the second visit was scheduled sessions helium-neon laser on the perioral region, which were conducted after the application of prescribed ointments and removal of surplus for 2 minutes in continuous mode power 10 W using a mirror of the nozzle at a distance of 1.5 cm was assigned to the correction of psycho-emotional state; at home - diet (exclusion from the diet of caviar, chocolate, citrus, hot and spicy food); the reception of the b vitamins; take antihistamines in the dose prescribed by your dermatologist.
25.10.2013 II visit. Complaints: the patient noted a significant decrease in feelings of tightness, itching and dryness of the lips.
Medical history: the patient continues treatment for atopic cheilitis.
Objective: regional lymph nodes not palpable, red border top and bottom lips pink, moderately moist, without pathological elements. On the lips and in the corners of the mouth crack is not detected. The hygiene index Green-Vermillion (GAMES, OHI-S) was 1.33, which corresponds to a satisfactory level of oral hygiene.
After 6 months (10.04.2014) after the start of treatment there were no complaints.
Objective: mucosa pink, moderately moist, without pathological elements of defeat. Regional lymph nodes were not palpable. The index of hygiene� Green-Vermillion (GAMES, OHI-S) was 1.5, which corresponds to a satisfactory level of oral hygiene.
01.11.2013 I visit. Patient N., 39 years old, came to the Department of therapeutic and pediatric stomatology sbei HPE Ryazgmu of the Ministry of health with complaints of pain and burning in the mucous membrane of the mouth, which increases during the meal; the presence of painful ulcers, which disappear spontaneously within 1-2 weeks.
The anamnesis of disease: exacerbation observed 3 times a year, mainly in spring and autumn for 5 years. Previously dentist prescribed rinsing weak antiseptic solutions, application of oil solution of vitamin A.
Life history: the patient suffers from chronic tonsillitis for 10 years, chronic enterocolitis for 6 years; are allergic to house dust.
Objective: regional submandibular lymph nodes are slightly enlarged, painful on palpation. The hygienic condition of the oral cavity poor - hygiene index Green-Vermillion (GAMES, OHI-S) was 2.3. Marked sharp edges of the teeth 36, 37, 47. On the lateral surface of the tongue on the left and on transition the crease to the right of erosion rounded shape with a rim of hyperemia, covered with whitish-gray patina, painful on palpation.
Diagnosis: chronic recurrent aphthous stomatitis.
Treatment: removal of above - and podlesney� dental plaque by ultrasound, polishing the necks of the teeth with a toothpaste that contains no fluoride, treatment of the affected areas of the oral mucosa with a swab moistened with 1% solution of hydrogen peroxide, insulation of ducts of salivary glands with a cotton roller, application of the claimed ointment on the affected area for 20 minutes. The patient was advised for one hour to refrain from taking food and water. The course of treatment was 14 days, the procedure was carried out 2-3 times a day.
15.11.2013 II visit. There were no complaints.
Medical history: the patient is continuing treatment for a chronic recurrent aphthous stomatitis.
Objective: regional lymph nodes are not palpable, the Lateral surface of the tongue and transitional fold pale pink, moderately moist, without pathological elements. The hygiene index Green-Vermillion (GAMES, OHI-S) was 1.2, which corresponds to a satisfactory level of oral hygiene.
After 6 months (01.05.2014,) after the start of treatment there were no complaints.
Objective: mucosa pink, moderately moist, without pathological elements of defeat. Regional lymph nodes were not palpable. The hygiene index Green-Vermillion (GAMES, OHI-S) was 1.33, which corresponds to a satisfactory level of oral hygiene.
Thus, the claimed method of treatment of inflammatory diseases�problems periodontal and mucous membranes of the oral cavity using the proposed tools provides a pronounced anti-inflammatory, immunomodulatory, anti-allergic, keratoplastic effect saving effect for a long time.
During treatment there were no cases of adverse complications, allergic reactions and side effects.
The method of treatment is easy to use in connection with high adhesive activity, physiologic, leads to full recovery.
1. Barer G. M. preventive dentistry. Diseases of the mucous membranes of the oral cavity: tutorial: 3 hrs / barer G. M. - 2nd ed. EXT. and Rev. - M.: GEOTAR-Media, 2010. - Part 3. - 256 p.: ill.
2. Karakov K. G. Fundamentals of periodontal therapy / K. G. Karakov, T. N. Vlasov, A. B. Egan // Dental South. - 2011. - No. 1. - Pp. 24-26.
3. Samylina H. A. Pharmacognosy: textbook / I. A. samylina, G. P. Yakovlev. - M.: GEOTAR-Media, 2013. - 976 p.: ill.
4. Tsepov L. M. Diagnosis, treatment and prevention of periodontal diseases / Tsepov L. M., A. I. Nikolaev, E. A. Mikheeva - 3-e Izd., Rev. and extra - M.: Medpress-inform, 2008. - 272 p.: ill.
Method of treatment of inflammatory periodontal diseases and the mucous membranes of the oral cavity, which consists in that for the treatment of these pathologies have used the ointment in petrolatum-lanolin base (2:1) in an amount of 74.0 g, which was introduced 25 ml of 40% alcohol tincture from the plant collection of the following composition (the combination of plant material: solvent-DOS�VA - 1:5), wt.h.: grass Campion drooping - 3 wt.h., the flowers of calendula drug - 1 wt.h., grass meadowsweet šestilepestnyj - 1 wt.h., with the subsequent addition to ointments 1.0 ml clove oil, which was applied on inflamed periodontal tissues and mucous membranes of the oral cavity for 20 minutes 2-3 times a day for 14 days, while encouraging patients to refrain from the intake of fluids and food for 1 hour.
SUBSTANCE: on completion of the antibacterial course, sodium hyaluronate in the form of a gel is single administered by means of a syringe with a needle of 2 cm long or more under an oral mucosa along a transitory fold into the points within projections of apexes of dental roots 1.4, 2.4, 3.6, 4.6 and into a point on the mid-line of projections of apexes of anterior roots of upper and lower jaw respectively. The needle is brought under the mucosa on the lower jaw by transecting the projections of an alveolar counterfort line. On the upper jaw - by transecting the projections of the upper counterfort line. While removing the needle from the mucosa, the syringe content is squeezed out. Sodium hyaluronate is administered into both jaws in an amount of 3.0 to 4.4 ml.
EFFECT: method enables increasing the jaw bone density within counterforts, as well as soft and bone tissues of periodontium.
4 tbl, 16 dwg, 3 ex
SUBSTANCE: invention refers to dentistry and concerns treating chronic generalised periodontitis. Implementing the above method is ensured by a complex preparation in the form of an ointment of the following composition: Vaselin - lanolin base (1:1) - 88.5 g, 70% ipecac infusion - 5.0 g, 70% scholar tree - 5.0 g, Ecdysterone - 0.02 g; eucalyptus oil - 1.0 g. The oil is applied as a therapeutic periodontal applicate on a gingival surface following application anaesthesia with 10% lidocaine, chairside oral hygiene, drug-induced treatment of the gingival margin with 1% Iodinolum and separation of salivary glands in the oral cavity, once a day for 2 hours for 4 weeks; the patients are recommended not to eat or drink for two hours. The preparation composition particularly provides capillary-reinforcing, anti-inflammatory, reparative and anaesthetic action.
EFFECT: method of treating is easy to use, physiologically-friendly, and provides the complete recovery.
SUBSTANCE: invention relates to a compound of formula (I) : or a salt thereof, wherein R1 and R5 are independently selected from H, OH and alkoxy; R2-R4 and R6-R8 are independently selected from H, OH, F, Cl, Br and I; R9 and R10 are C2-C8 alkenyl; under the condition that at least one of R1, R5 and R7 is OH or alkoxy; at least one of R2-R4, R6 and R8 is F, Cl, Br or I; and R2 and R6 are Cl. The invention also relates to an antibacterial composition and treatment methods.
EFFECT: improved properties.
18 cl, 7 ex, 10 tbl
SUBSTANCE: agent for treating inflammatory periodontal and oral mucosal diseases associated with Helicobacter infection contains silicone glycerohydrogel of Si(C3H7O3)4·6C3H8O3·24H2O and bismuthate tripotassium dicitrate of formula [HOC(CH2COO)2COO]2K3Bi in the following proportions, wt %: bismuthate tripotassium dicitrate 1.0-2.5; silicone glycerohydrogel - the rest up to 100. The method of treating inflammatory periodontal and oral mucosal diseases consists in a combination of systemic standard anti-Helicobacter therapy and a local effect of the above agent on the involved region. Particularly, treating periodontitis is ensured by applying the agent on the gingival surface and introducing it into the gingival pockets once a day for 10 min; the therapeutic course makes 5-6 days. The oral mucosal diseases are treated by applying the agent 0.1 mm thick with a glass spatula on the involved oral mucosa 2 times a day; the therapeutic course is 12 days.
EFFECT: formulation of the agent provides achieving the high therapeutic effect; the dosage form is easy to be applied locally.
4 cl, 2 dwg, 1 tbl, 2 ex
SUBSTANCE: method includes the preparation of a carious cavity, opening the tooth cavity, creation of an access to root canals, extension of their orifice. Removal of a decayed material from the root canals and their drug treatment are carried out. After that, performed are: wide opening of the apical tooth orifice, mechanical and drug removal of periapical pathological exudative formations in the focus of periapical inflammation through the root canal. Before filling the canal with a filling material the gel "Lamifaren" is introduced into the focus of periapical destruction. Such introduction is performed three times after a day under temporary stopping. The gel "Lamifaren" is introduced inside in a dose of 50 g 2 times per day for 30 days.
EFFECT: application of the invention accelerates bone tissue regeneration due to the active release of an active substance calcium alginate, provides stable remission due to local and systemic detoxifying effect.
SUBSTANCE: treatment is two-staged; at the first stage, gingival pockets are rinsed with a stream of 1.5% hydrogen peroxide in a cannula delivered through the gingival pockets around the teeth. If observing the exposed furcation of premolars and molars, the cannula is brought under the root furcation. Thereafter, the gingival pockets are similarly rinsed with an aqueous tincture of garden sage herb for 3-5 days, then with an aqueous tincture of camomile blossom for 3-5 days, an aqueous tincture of plantain leaves daily for the following 3-5 days; each rinsing procedure is followed by applications of cotton drains impregnated with the respective aqueous herbal tincture introduced by the cannula on gingival mucous membranes for 1 hour; that is combined with prescribing oral baths with the respective aqueous herbal tincture introduced by the cannula daily 5-7 times a day. The second stage involves instillations of Normoflorin-B or Bifidumbacterin in the cannula delivered through the gingival pockets around the teeth, brought under the furcation if observing the exposed furcation of premolars and molars; the gingival mucous membranes are laid with cotton drains with the above preparation for 2 hours daily for 5-10 days.
EFFECT: method enables providing the higher clinical effectiveness.
2 cl, 1 ex
SUBSTANCE: at the first stage, after removing supra- and sub-gingival dental calculus and granulations, cleaning the teeth professionally, rinsing gingival pockets by stream infusions of 1.5% hydrogen peroxide in a cannula delivered through the gingival pockets around the teeth, brought under root furcation if observing the exposed furcation of premolars and molars; the preparation "Calsept" is administered within the frontal teeth for 5-7 days daily into the gingival pockets bringing the cannula similarly around the teeth, whereas the preparation "Calsept-Iodo" is administered within the distal teeth; the dentist recommends that the patient does not eat for 2 hours thereafter. The second stage involves administering a preparation containing bifidus bacteria, e.g. Normoflorin-B or Bifidumbacterin by instillations in a cannula delivered through the gingival pockets around the teeth, brought under the furcation if observing the exposed furcation of premolars and molars; gingival mucous membranes are laid with cotton drains with the preparation for 2 hours daily for 5-10 days.
EFFECT: using the method provides increasing the therapeutic effect ensured by the antibacterial effect, odontotropic and anaesthetic action, bone tissue recovery, action of the therapeutic preparation in difficult-to-access anatomic formations.
2 cl, 1 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to health-promoting compositions and methods for preparing them. A method for preparing the composition of non-living lactic acid bacilli, possessing an ability of specific binding to Streptococcus mutans, involves the following stages: heating a cell suspension of lactic acid bacillus or a mixture of lactic acid bacilli possessing an ability of specific binding to Streptococcus mutans from an initial temperature of less than 40°C to a pasteurisation temperature of 75 to 85°C with a temperature variation within the range of 0.5 to 2°C/min, keeping the heated suspension at a pasteurisation temperature of 20 to 40 minutes and cooling the suspension to a final temperature of less than 40°C within the range of 0.5 to 2°C/min. The specific binding the cell suspension of the lactic acid bacillus or the mixture of lactic acid bacilli to Streptococcus mutans is stable to heat treatment and/or resistant to proteases and/or calcium-dependent and/or is observed within the range of pH values falling within the range of 4.5 and 8.5, and/or in the saliva environment.
EFFECT: invention enables producing the agent preventing or delaying the caries lesion formation.
9 cl, 4 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: group of inventions refers to oral care compositions containing a basic amino acid or its salt. The presented oral care composition promoting the dentine defect closure in the oral cavity contains arginine in the free form or in the form of a salt, and an abrasive substance representing synthetic amorphous silica and containing small particle fractures making at least approximately 5% of total weight of the composition, wherein the particles of the small particle fracture having d50 from 3 to 4 mcm. What is also presented is a method of treating sensitive teeth in the oral cavity involving using the oral treatment with this composition, as well as using arginine as a part of the oral care composition and for producing a therapeutic agent, wherein the above composition and agent contain the above abrasive material containing the small particle fracture.
EFFECT: group of inventions provide the effective dentin defect closure in the patient's oral cavity.
8 cl, 1 tbl, 6 ex
SUBSTANCE: carious cavity is prepared. Then it is treated instrumentally and antiseptically. A hole of an apical canal of a causative tooth is expanded. Methylene blue is introduced into the cyst through a root canal at a depth of 7-10 min. The cyst envelope is exposed to a laser light generated by a diode laser through the root canal for 30-60 s by means of a needle light guide. The exposure is continued from the vestibular or oral surface for 60.0-120.0 s by means of a plate light guide of intensity 0.5-1 W, wave length 625-630 nm in a pulse mode. Before the root canals of the causative tooth is hermetically sealed, Collap-An gel with metrogil 1.0-1.5 ml is introduced into the cyst.
EFFECT: method enables provides increasing clinical effectiveness, avoiding the complications by removing the cyst envelope completely that enables restoring the bone defect structure completely.
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention relates to pharmaceutics, in particular, described is a capsule, containing a capsule envelope, which includes an encapsulated liquid solution of N-(4-(4-((2-(4-chlorophenyl)-5,5-dimethyl-1-cyclohex-1-en-1-yl)methyl)piperazin-1-yl)benzoyl)-4-(((1R)3-(morpholin-4-yl)-1-(phenylsulphanyl)methyl)propyl)-amino)-3-((trifluoromethyl)sulphonyl)benzenesulphonamide (ABT-263) or its bis-hydrochloride salts in a non-ethanol carrier. As filling agents used are: a phospholipid, a solubilising agent for the phospholipid, selected from glycols, glycolides, glycerides and their mixtures, a surface-active substance of a non-phospholipid type and a sulphur-containing antioxidant in an amount, effective for the reduction of oxidising ABT-263 degradation in storage. The sulphur-containing antioxidant is selected from sulphites, bisulphites, metabisulphites and thiosulphites and their mixtures. A method of the capsule obtaining is also described. The capsule is used for treating a disease, characterised by the overexpression of one or several anti-apoptotic proteins of the Bcl-2 family, for instance, cancer.
EFFECT: invention provides a long storage term for the said capsule.
33 cl, 3 dwg, 20 tbl, 14 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention relates to medicine, in particular to a pharmaceutical composition in the form of the extrudate, containing at least one pharmaceutically active substance in the form of needles, characterised by the fact that the ratio of the particle size of the needle-like active substance to the diameter of strands constitutes at least 1:25.
EFFECT: invention makes it possible to obtain the more homogeneous extrudate.
11 cl, 13 ex, 10 dwg
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to pharmaceutics, namely represents pharmaceutical formulations containing 9-cis-retinyl esters in a lipid excipient. The pharmaceutical formulations containing 9-cis-retinyl esters are described to be applicable in a retinoid replacement therapy for treating retinal degenerations in individuals.
EFFECT: using the formulations for the retinoid replacement therapy for treating retinal degenerations in individuals.
73 cl, 14 dwg, 2 tbl, 6 ex
SUBSTANCE: wound surface is treated with 3.0-1.5% hydrogen peroxide; then keeping the wound wet, Ichthyosin dressing prepared by streptocide powder 0.5-2.5g and Ichthyol ointment 5.0-10.0g dissolved in castor oil 94.5-87.5ml is applied. The agent is applied once a day; the therapeutic course makes 16 days. That is combined with performing an integrated treatment.
EFFECT: invention provides both the antibacterial and anti-infectious, and local anti-inflammatory, local anaesthetic, wound-healing effects, improves the blood supply, stimulates the epidermis regeneration, intensifies the keratosis processes that enables accelerating the wound cleansing from the purulonecrosis process, and a length of preparation for aurografting.
1 tbl, 2 ex
SUBSTANCE: agent contains the following per 1 suppository: 1.0 g glutaminic acid and 0.4 g of a 10% alcohol extract of propolis as active substances, as well as 2.0 g cacao oil, 0.15 g Cremophore CO-40 and 0.1 g PEG 400 as a base.
EFFECT: agent has high bioavailability, prolonged action, uniform release of active substances and a wide range of biological and medicinal activity.
2 cl, 1 dwg, 2 tbl, 9 ex
SUBSTANCE: inventions refers to medicine, namely to pulmonology, and can be used for treating a pulmonary disorder in a patient. That is ensured by administering an effective dose of the nebulised liposomal amikacin formulation of 100 to 2,500 mg daily within the cycle of treatment, which involves the period of administration from 15 to 75 days and the following withdrawal period from 15 to 75 days. The cycle of treatment repeats at least twice.
EFFECT: invention provides improving the pulmonary function, which is supported for at least 15 days after the termination of treatment, and increasing the one-second forced expiratory volume (FEV1).
28 cl, 16 tbl, 11 dwg, 3 ex
SUBSTANCE: invention discloses a method of preventing agglomeration of particles of an aripiprazole or 7-[4-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)butox]-1H-quinolin-2-one active ingredient in a suspension containing silicone oil and/or a silicone oil derivative in a dispersion medium, wherein the particle size of the active ingredient is 0.1-200 mcm. The method comprises mixing an active ingredient with silicone oil and/or silicone oil derivative in a dispersion medium such that the silicone oil and/or silicone oil derivative is contained in an amount of 0.001-0.2 pts.wt per 100 pts.wt of the active ingredient contained in the suspension. The invention also relates to a hardened composition for preparing a suspension administered by injection or orally.
EFFECT: preventing agglomeration of active ingredients in a suspension without special treatment.
9 cl, 4 tbl, 9 ex
SUBSTANCE: invention represents an antifungal preparation in suppositories for children containing recombinant human interferon 2α and fluconazole, wherein lysozyme, Licopid and dimephosphone are additionally introduced.
EFFECT: preparation possesses the high clinical effectiveness in the fungal diseases in children that leads to reducing the length of treatment and prolonging the intercurrent period.
1 tbl, 3 ex
SUBSTANCE: invention refers to a method for preparing a phospholipid nanoparticle enclosed chlorine E6 therapeutic agent applicable as a remedy for photodynamic therapy. An aqueous solution of maltose prepared by heating is mixed with chlorine E6 and then mixed with an aqueous emulsion of phosphatidylcholine. The prepared emulsion is subject to several homogenisation cycles under high pressure of 500-1,000 atm at a temperature of 40-50°C followed by neutralising in alkaline water and lyophilising.
EFFECT: more effective application of the compound.
1 tbl, 1 ex
SUBSTANCE: method involves preparing a liquid composition containing a pharmaceutical active ingredient, a mixture of solvents containing water, isopropanol in an amount of 5 wt % to 20 wt % and propylene glycol in an amount of 2 wt % to 25 wt %, and a phospholipid foaming agent in an amount of 2 wt % to 25 wt %, foaming the liquid composition mechanically with no propellant used, and measuring the foam volume and stability. That is followed by transforming the nature and/or changing the concentration of the pharmaceutically active ingredient and/or the phospholipid foaming agent and/or changing the concentration of one of the solvents to produce 250 ml of the liquid composition. The above liquid composition is expected to produce foam in the volume of 400 ml and with the stability so that 50% of an initial foam volume is observed so far after the 10-minute hold-up and measured by the standard SITA procedure. The invention also relates to a composition applicable for topical use and prepared by the method described above.
EFFECT: preparing the composition presented by the stable foam.
22 cl, 18 dwg, 1 tbl, 18 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: present invention refers to a compound of formula such as below , wherein Z is oxygen; Y is hydrogen or a sequence as follows: -O-C(R4)-V-(C=O)-R5; V is oxygen; R1 and R4 are identically or independently hydrogen or a C1-4 alkyl; R2 and R5 are identically or independently a C1-10 alkyl.
EFFECT: these compounds can be applicable in therapy for treating pathologies or disorders related to the presence of Propionibacterium acnes, eg acne-like skin disorders.
5 cl, 2 tbl, 2 ex