Method for comparative assessment of current activity of cerebral hemispheres

FIELD: medicine.

SUBSTANCE: EEG signal is recorded and digitised in symmetrical zones of the right and left cerebral hemispheres by monopole and dipole methods. After digitising, mean EEG signal values are calculated. A positive (+) active electrode position, wherein the EEG signal is supposed to be more electrically negative shows the hemisphere with the greater activity.

EFFECT: method enables simplifying and detecting the more active cerebral hemisphere more reliably.

2 ex

 

The invention relates to medicine, in particular to identify indicators of current functional asymmetry in the activity of the cerebral hemispheres (GM).

One method of comparing the current activity of the hemispheres of the GM method is register level of constant potential (SCP) of the brain in symmetrical points of the right and left hemispheres [2, 3]. The main source of generation SCP brain potentials are of vascular origin, created by the blood-brain barrier and pH-responsive to jugular vein from the brain of blood. The concentration of hydrogen ions in the blood vessels of the brain depends on the intensity of energy metabolism, because acids are the end product of energy metabolism. This circumstance allows to use SCP to assess cerebral energy metabolism. Growth SCP denotes a decrease (acidotic shift) cerebral pH.

In the analysis of hemispheric activity monopolar and bipolar disposal methods soft starters are equivalent in their results. In the case of monopolar method of assignment of AMR positive electrodes of different registration channels are set at symmetric points of the temporal areas of the right and left hemisphere, and a negative electrode at the reference point is the right hand. In this case, the more active hemisphere corresponds bol�the neck of the value of SCP. In the case of interhemispheric bipolar derivations SCP negative electrode is installed on the left and positive on the symmetrical point of the temporal areas of the right hemisphere. In this case a negative value, the SCP indicates greater activity of the left hemisphere and positive about greater activity of the right hemisphere of the GM.

Check the soft starter is not the only method by which to compare the current activity of the symmetric regions of the hemispheres of the GM.

The most common method of the study of bioelectric activity of the GM method is the registration of electroencephalogram (EEG). But to give an integrated assessment of current activity in the hemispheres at the points of registration of EEG - trivial task.

The increase in the activity of different brain areas in the EEG manifests itself, first of all, the change of the spectral characteristics of the signal increases relative spectral power of α - and especially β-rhythms, and the relative spectral power of δ - and θ-rhythm is reduced, which is accompanied by an overall reduction of the amplitude characteristics of the EEG signal [1]. In contrast, reduced activity level normal is accompanied by an increase in the relative spectral power of δ - and θ-bands with decreasing the relative spectral power quick (α, β) rhythms and an increase of the amplitude characteristics�IR signal EEG. The complexity of integrated assessment activity of various brain areas in spectral characteristics of the EEG signal due to the fact that when you activate the various activities of the brain can be observed an increase in the correlation between the SCP on the head surface and the spectral power of different rhythms [3].

However, a comparison of current activity in the symmetrical areas of the hemispheres, based on comparing "averages" of the digitized EEG signal characterizing the offset of the mean value relative to the zero line of the signal. The average value of the digitized sine wave having the same symmetrical to the zero line the positive and negative parts of the signal is 0, i.e. coincides with the zero line. The same thing will happen when you register the complex signal spectrum with the same intensity of negative and positive parts of the signal. Upon registration of EEG signal, this situation is extremely rare and in very short time intervals. The asymmetry of the positive and negative parts of the EEG signal depends on the ratio between TPSP and GAP, summation which contribute most to the formation of the EEG. But this ratio depends on the difference in the activity of those brain areas, which are registering the active electrodes In different activity areas which are active recording electrodes, they have a different effect on the offset mean value of the EEG signal from the zero line". In the case where the active electrodes are placed on symmetrical areas of the left and right hemispheres can be compared in their activity by mean values of EEG signals.

When you register the SCP in case of arrangement of the positive active electrode over the active area recorded a positive value of SCP, the greater the higher the activity [3].

The study authors showed that EEG and calculating the average value in the case of the location of the positive active electrode over the active region, the average value of the signal is less (more electronegative). Conducted by the authors on 30 subjects comparison identify the increase in the temporal areas of the right and left hemispheres of the method of registration of the SCP (the unit of ANAS [4]) described here and the method of registration of EEG with the calculation of the average values of the signal showed 100% agreement between the results (P<0.01). To record EEG in these studies used a range of connected computers biopotential amplifiers - MPC-02 (TU 3-2401-91) and MP30B-CE (Biopac Systems, Inc.).

Such interdependence between the SCP and the mean value of the EEG signal (offset of�with respect to the zero line) is quite consistent with known literature data on the relationship between these electrophysiological parameters [3].

The aim of the proposed method is the implementation of a comparative assessment of current activity of the cerebral hemispheres, based on the most common method, the study of bioelectric activity of the brain - a method of registration of EEG.

This way, as with registration, the SCP can be implemented both in monopolar EEG registrations in symmetrical areas of the right and left hemispheres, and with the help of registration interhemispheric bipolar EEG derivations.

The invention is as follows.

In the case of registration monopolar derivations active positive (+) electrodes are placed on symmetrical areas of the right and left hemisphere. After registration and digitization of EEG signal are calculated average values of these signals, characterizing the offset of these values relative to the zero line. More active area (corresponding to a larger value SCP) has a smaller value of the mean values of EEG signal.

In case of registration of EEG bipolar method in the presence of 2 recording channels is simultaneous recording of EEG, in which the positive (+) one active electrode leads placed near the negative (-) active electrode of the second discharge in the study area of one hemisphere, and a pair of active electrodes of opposite polarity�ti are similar to the study area of the opposite hemisphere. In the case of single-channel EEG bipolar manner by successive 2-fold registration with the change of location of the active electrodes: first, the positive active electrode is installed on the investigated area of one hemisphere and negative active electrode - symmetrical area of the opposite hemisphere; then their place will change places. Reference electrodes are placed in their usual spots. After registration and digitization of EEG signal are calculated average values of these signals, which characterize the offset relative to the zero line. In those cases, when the positive active electrode is located over an active area (with greater magnitude SCP), the calculated average value of the EEG signal is less (is more electronegative).

The implementation of the method is as follows.

For recording and analysis of EEG signals can be used by any certified connect to a computer EEG or biopotential amplifiers function with EEG registration.

The test for 10-20 with recorded EEG with symmetrical points of the right and left hemispheres.

In the case of registration monopolar derivations active positive (+) electrodes are placed on symmetrical areas of the right and left �of Rosaria. After registering and digitizing a 5 - 10 second bitartarate plots of EEG signal are calculated average values of these signals. More active area has a smaller value of the mean values of EEG signal.

In case of registration of EEG bipolar method in the presence of 2 recording channels is simultaneous recording of EEG, in which the positive (+) one active electrode leads placed near the negative (-) active electrode of the second discharge in the study area of one hemisphere, and a pair of active electrodes of opposite polarity are similar to the study area of the opposite hemisphere. In the case of single-channel EEG bipolar manner by successive 2-fold registration with the change of location of the active electrodes: first, the positive active electrode is installed on the investigated area of one hemisphere and negative active electrode - symmetrical area of the opposite hemisphere; then their place will change places. Reference electrodes are placed in their usual spots. After registering and digitizing a 5 - 10 second bitartarate plots of EEG signal are calculated average values of these signals. In those cases, when the positive active electrode is located over the active zo�Oh (with greater magnitude SCP), the calculated average value of the EEG signal is less (is more electronegative).

The implementation of the method is illustrated by the examples below.

Example 1.

Test S. G. R., 18.

EEG acquisition was performed with a bipolar way. First active positive electrode was placed on the temporal region of the left hemisphere, and negative active electrode at the symmetric point in the temporal region of the right hemisphere. The reference electrode was attached to the right ear using a special clothespins. The EEG signal was applied to the EEG unit of the device MPC-02, and from the output of the device through the ADC to the computer. Produced instantaneous values of EEG signal 10-second intervals (128 samples per second), and on the basis of an array of numbers calculated average value. Then symmetrically changed the location of the electrodes - a positive active electrode was placed on the temporal region of the right hemisphere, negative and reference electrodes, respectively, in the left temporal region and the left ear. Again recorded instantaneous values of 10-second intervals of the EEG was calculated and the average value.

When the location of the positive active electrode on the temporal region of the left hemisphere the mean value was +1,2 µv, while the s�the proposal on the temporal region of the right hemisphere - +6,4 mV. Consequently, the more active is the temporal area of the left hemisphere.

Example 2.

Test L. D. V., 20 years.

EEG acquisition was performed monopolar method. Positive active electrode was placed at symmetric points in the temporal regions of the left and right hemisphere, negative active electrodes and reference electrodes, respectively - on mastoid and the ear on the opposite side.

The EEG signals were fed to the amplifier channels of biopotential MP30B-CE (Biopac Systems, Inc.), connected to the computer. Produced a 20-second recording of EEG. After reviewing the record was allocated a 10-second becarefully recording EEG and was given the command to the application program to calculate averages of the signals from both leads.

The average value of EEG derivations with the location of the positive active electrode on the temporal region of the right hemisphere amounted to 30 mV, and the average value of the EEG in lead with the location of the positive active electrode on the temporal region of the left hemisphere - +17,8 mV. Consequently, the more active is the temporal area of the right hemisphere.

The LIST of references

1. Zenkov L. R., Ronkin M. A. Functional diagnostics of nervous diseases. - M: 1991.

2. Fokin V. F., Avira V. M., Ponomareva N. In., Kiselev V. N. Method of registration shift level post�permanent electric potential of the brain. / The patent for invention of the Russian Federation No. 2007116. Published 15.02.1994.

3. Fokin V. F., Ponomareva N. In. The energetic physiology of the brain.: "Antidoron" 2003. - 288 p.

4. http://www.neurotek.mpi.ru/

Method for comparative evaluation of current activity of the cerebral hemispheres, including the registration and digitization of EEG signal in symmetrical areas of the right and left hemispheres of the brain monopolar or bipolar manner, characterized in that after digitizing calculate the mean values of EEG signals, and the hemisphere with greater activity in the study area is determined by the location of the positive (+) of the active electrode, wherein the average value of the EEG signal was more electronegative, i.e., had a lower value.



 

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2 ex, 1 tbl

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1 ex, 1 tbl

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1 ex

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2 tbl, 1 dwg, 1 ex

FIELD: medicine.

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3 cl, 1 dwg, 1 tbl

FIELD: medicine, neurology, professional pathology.

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EFFECT: higher accuracy of diagnostics.

6 ex, 1 tbl

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