Method for comparative assessment of current activity of cerebral hemispheres
SUBSTANCE: EEG signal is recorded and digitised in symmetrical zones of the right and left cerebral hemispheres by monopole and dipole methods. After digitising, mean EEG signal values are calculated. A positive (+) active electrode position, wherein the EEG signal is supposed to be more electrically negative shows the hemisphere with the greater activity.
EFFECT: method enables simplifying and detecting the more active cerebral hemisphere more reliably.
The invention relates to medicine, in particular to identify indicators of current functional asymmetry in the activity of the cerebral hemispheres (GM).
One method of comparing the current activity of the hemispheres of the GM method is register level of constant potential (SCP) of the brain in symmetrical points of the right and left hemispheres [2, 3]. The main source of generation SCP brain potentials are of vascular origin, created by the blood-brain barrier and pH-responsive to jugular vein from the brain of blood. The concentration of hydrogen ions in the blood vessels of the brain depends on the intensity of energy metabolism, because acids are the end product of energy metabolism. This circumstance allows to use SCP to assess cerebral energy metabolism. Growth SCP denotes a decrease (acidotic shift) cerebral pH.
In the analysis of hemispheric activity monopolar and bipolar disposal methods soft starters are equivalent in their results. In the case of monopolar method of assignment of AMR positive electrodes of different registration channels are set at symmetric points of the temporal areas of the right and left hemisphere, and a negative electrode at the reference point is the right hand. In this case, the more active hemisphere corresponds bol�the neck of the value of SCP. In the case of interhemispheric bipolar derivations SCP negative electrode is installed on the left and positive on the symmetrical point of the temporal areas of the right hemisphere. In this case a negative value, the SCP indicates greater activity of the left hemisphere and positive about greater activity of the right hemisphere of the GM.
Check the soft starter is not the only method by which to compare the current activity of the symmetric regions of the hemispheres of the GM.
The most common method of the study of bioelectric activity of the GM method is the registration of electroencephalogram (EEG). But to give an integrated assessment of current activity in the hemispheres at the points of registration of EEG - trivial task.
The increase in the activity of different brain areas in the EEG manifests itself, first of all, the change of the spectral characteristics of the signal increases relative spectral power of α - and especially β-rhythms, and the relative spectral power of δ - and θ-rhythm is reduced, which is accompanied by an overall reduction of the amplitude characteristics of the EEG signal . In contrast, reduced activity level normal is accompanied by an increase in the relative spectral power of δ - and θ-bands with decreasing the relative spectral power quick (α, β) rhythms and an increase of the amplitude characteristics�IR signal EEG. The complexity of integrated assessment activity of various brain areas in spectral characteristics of the EEG signal due to the fact that when you activate the various activities of the brain can be observed an increase in the correlation between the SCP on the head surface and the spectral power of different rhythms .
However, a comparison of current activity in the symmetrical areas of the hemispheres, based on comparing "averages" of the digitized EEG signal characterizing the offset of the mean value relative to the zero line of the signal. The average value of the digitized sine wave having the same symmetrical to the zero line the positive and negative parts of the signal is 0, i.e. coincides with the zero line. The same thing will happen when you register the complex signal spectrum with the same intensity of negative and positive parts of the signal. Upon registration of EEG signal, this situation is extremely rare and in very short time intervals. The asymmetry of the positive and negative parts of the EEG signal depends on the ratio between TPSP and GAP, summation which contribute most to the formation of the EEG. But this ratio depends on the difference in the activity of those brain areas, which are registering the active electrodes In different activity areas which are active recording electrodes, they have a different effect on the offset mean value of the EEG signal from the zero line". In the case where the active electrodes are placed on symmetrical areas of the left and right hemispheres can be compared in their activity by mean values of EEG signals.
When you register the SCP in case of arrangement of the positive active electrode over the active area recorded a positive value of SCP, the greater the higher the activity .
The study authors showed that EEG and calculating the average value in the case of the location of the positive active electrode over the active region, the average value of the signal is less (more electronegative). Conducted by the authors on 30 subjects comparison identify the increase in the temporal areas of the right and left hemispheres of the method of registration of the SCP (the unit of ANAS ) described here and the method of registration of EEG with the calculation of the average values of the signal showed 100% agreement between the results (P<0.01). To record EEG in these studies used a range of connected computers biopotential amplifiers - MPC-02 (TU 3-2401-91) and MP30B-CE (Biopac Systems, Inc.).
Such interdependence between the SCP and the mean value of the EEG signal (offset of�with respect to the zero line) is quite consistent with known literature data on the relationship between these electrophysiological parameters .
The aim of the proposed method is the implementation of a comparative assessment of current activity of the cerebral hemispheres, based on the most common method, the study of bioelectric activity of the brain - a method of registration of EEG.
This way, as with registration, the SCP can be implemented both in monopolar EEG registrations in symmetrical areas of the right and left hemispheres, and with the help of registration interhemispheric bipolar EEG derivations.
The invention is as follows.
In the case of registration monopolar derivations active positive (+) electrodes are placed on symmetrical areas of the right and left hemisphere. After registration and digitization of EEG signal are calculated average values of these signals, characterizing the offset of these values relative to the zero line. More active area (corresponding to a larger value SCP) has a smaller value of the mean values of EEG signal.
In case of registration of EEG bipolar method in the presence of 2 recording channels is simultaneous recording of EEG, in which the positive (+) one active electrode leads placed near the negative (-) active electrode of the second discharge in the study area of one hemisphere, and a pair of active electrodes of opposite polarity�ti are similar to the study area of the opposite hemisphere. In the case of single-channel EEG bipolar manner by successive 2-fold registration with the change of location of the active electrodes: first, the positive active electrode is installed on the investigated area of one hemisphere and negative active electrode - symmetrical area of the opposite hemisphere; then their place will change places. Reference electrodes are placed in their usual spots. After registration and digitization of EEG signal are calculated average values of these signals, which characterize the offset relative to the zero line. In those cases, when the positive active electrode is located over an active area (with greater magnitude SCP), the calculated average value of the EEG signal is less (is more electronegative).
The implementation of the method is as follows.
For recording and analysis of EEG signals can be used by any certified connect to a computer EEG or biopotential amplifiers function with EEG registration.
The test for 10-20 with recorded EEG with symmetrical points of the right and left hemispheres.
In the case of registration monopolar derivations active positive (+) electrodes are placed on symmetrical areas of the right and left �of Rosaria. After registering and digitizing a 5 - 10 second bitartarate plots of EEG signal are calculated average values of these signals. More active area has a smaller value of the mean values of EEG signal.
In case of registration of EEG bipolar method in the presence of 2 recording channels is simultaneous recording of EEG, in which the positive (+) one active electrode leads placed near the negative (-) active electrode of the second discharge in the study area of one hemisphere, and a pair of active electrodes of opposite polarity are similar to the study area of the opposite hemisphere. In the case of single-channel EEG bipolar manner by successive 2-fold registration with the change of location of the active electrodes: first, the positive active electrode is installed on the investigated area of one hemisphere and negative active electrode - symmetrical area of the opposite hemisphere; then their place will change places. Reference electrodes are placed in their usual spots. After registering and digitizing a 5 - 10 second bitartarate plots of EEG signal are calculated average values of these signals. In those cases, when the positive active electrode is located over the active zo�Oh (with greater magnitude SCP), the calculated average value of the EEG signal is less (is more electronegative).
The implementation of the method is illustrated by the examples below.
Test S. G. R., 18.
EEG acquisition was performed with a bipolar way. First active positive electrode was placed on the temporal region of the left hemisphere, and negative active electrode at the symmetric point in the temporal region of the right hemisphere. The reference electrode was attached to the right ear using a special clothespins. The EEG signal was applied to the EEG unit of the device MPC-02, and from the output of the device through the ADC to the computer. Produced instantaneous values of EEG signal 10-second intervals (128 samples per second), and on the basis of an array of numbers calculated average value. Then symmetrically changed the location of the electrodes - a positive active electrode was placed on the temporal region of the right hemisphere, negative and reference electrodes, respectively, in the left temporal region and the left ear. Again recorded instantaneous values of 10-second intervals of the EEG was calculated and the average value.
When the location of the positive active electrode on the temporal region of the left hemisphere the mean value was +1,2 µv, while the s�the proposal on the temporal region of the right hemisphere - +6,4 mV. Consequently, the more active is the temporal area of the left hemisphere.
Test L. D. V., 20 years.
EEG acquisition was performed monopolar method. Positive active electrode was placed at symmetric points in the temporal regions of the left and right hemisphere, negative active electrodes and reference electrodes, respectively - on mastoid and the ear on the opposite side.
The EEG signals were fed to the amplifier channels of biopotential MP30B-CE (Biopac Systems, Inc.), connected to the computer. Produced a 20-second recording of EEG. After reviewing the record was allocated a 10-second becarefully recording EEG and was given the command to the application program to calculate averages of the signals from both leads.
The average value of EEG derivations with the location of the positive active electrode on the temporal region of the right hemisphere amounted to 30 mV, and the average value of the EEG in lead with the location of the positive active electrode on the temporal region of the left hemisphere - +17,8 mV. Consequently, the more active is the temporal area of the right hemisphere.
The LIST of references
1. Zenkov L. R., Ronkin M. A. Functional diagnostics of nervous diseases. - M: 1991.
2. Fokin V. F., Avira V. M., Ponomareva N. In., Kiselev V. N. Method of registration shift level post�permanent electric potential of the brain. / The patent for invention of the Russian Federation No. 2007116. Published 15.02.1994.
3. Fokin V. F., Ponomareva N. In. The energetic physiology of the brain.: "Antidoron" 2003. - 288 p.
Method for comparative evaluation of current activity of the cerebral hemispheres, including the registration and digitization of EEG signal in symmetrical areas of the right and left hemispheres of the brain monopolar or bipolar manner, characterized in that after digitizing calculate the mean values of EEG signals, and the hemisphere with greater activity in the study area is determined by the location of the positive (+) of the active electrode, wherein the average value of the EEG signal was more electronegative, i.e., had a lower value.
SUBSTANCE: real-time and time-delay EEGs are recorded and processed by continuous wavelet decomposition. Scalograms of a wavelet coefficient matrix are drawn. That is followed by the further analysis of chains of local minimums and maximums on the successively drawn scalograms. The chains of the local minimums and maximums are formed. Basic chain parameters required for the further analysis are determined. The chains are typed according both to frequency and energy parameters. The averaged chains of the local minimums and maximums are derived. The number of chains is used to construct frequency- and energy-based incidence cross tables to be statistically processed; the incidence can fall within the range of an absolute value, and be rated by the common number of chains in the tables, the common number in the respective line, and the common number in the respective column.
EFFECT: invention enables providing the higher accuracy and information value of the EEG analysis in various functional conditions by detecting the fine structure of the local minimums and maximums carrying the information of respective brain centres activity.
15 dwg, 2 ex
SUBSTANCE: polysomnography is conducted. Slow sleep phases (SSP) and fast sleep phases (FSP) are determined. A maturity index of integrative sleeping apparatuses (MIS) is calculated by formula MIS = SSP/FSP. If the MIS is less than 1.5, a physiologically optimum structure of the nocturnal sleep is stated in a healthy child.
EFFECT: method enables assessing the quality of the nocturnal sleep in the children.
1 tbl, 2 ex
SUBSTANCE: invention refers to medicine and can be used in labour hygiene and occupational health problems. A digital camera is fixed on a driver's head in front of his eyes and a blinding light source. Crossing coordinates of a display plane and straight lines connecting an eye centre with each blinding source are determined. Blackout areas comparably sized with a head lamp light of the oncoming car are displayed. A maximum contrast negative image of the blinding light sources read out from the camera is presented on a transparent display.
EFFECT: method provides the more effective driver's eyes protection if blinded by the light of the oncoming car that is ensured by displaying the maximum contrast negative image of the segments corresponding to the blinding head lamp light.
4 cl, 2 dwg
SUBSTANCE: group of inventions refers to medicine and medical equipment. A distance of the upper to lower eyelids of at least one eye is measured over a period of time, Eye openness coefficients varying within the value of wide open eye, through the value of partially open eye to the value of completely closed eye are determined. The eye openness coefficients are graphed. The eye openness coefficients variations over the period of time are compared to a reference eye closure model indicating the microsleep cases. Besides, the method is implemented according to the version, which provides notifying an operator if the microsleep has been detected, by signalling. The method is also implemented by comparing the microsleep models with the eye openness coefficients variations as shown by EEG and EOG. That is ensured by using a device comprising an infrared emitter, which is connected to an image selector. A microprocessor with an electronic procedure of microsleep detection configured to detect face, eyes and eyelids images in a digital image and to calculate the eye openness coefficient with determining a microsleep-specific coefficient, and presenting the obtained information in the form of graphical presentation of the eye openness coefficients at the selected moments of time. A memory unit connected to the microprocess and comprising the reference eye closure models to be compared to the eye openness coefficients at the selected moments of time.
EFFECT: invention enables providing the more reliable assessment of microsleep that is ensured by microsleep detection at the early stages of falling asleep.
28 cl, 6 dwg
SUBSTANCE: pulse electric activity of sensorimotor central neurons is recorded in experimental animals adapted to hypoxia. The recorded activity frequency is modulated by a multivibrator and an electroacoustic transducer; the signals are copied and transferred onto a carrier. The patient is exposed to distant acoustic signals with the use of the laser generator. The exposure is sequential and starts with sessions at frequency 5-8 Hz for 5-7 minutes and follows with sessions at frequency 10-15 Hz for 5-8 minutes. The sessions are daily, one session a day; the therapeutic course is 10-14 sessions.
EFFECT: method enables using the drug-free modalities and normalise the blood pressure that is ensured by providing the mode and sequence of acoustic signal flow.
2 tbl, 3 ex
SUBSTANCE: EEG frequency response is pre-determined by a period analysis in a highly-watchful live operator being involved in active visual-motor activities and in actual activities. Theta-, alpha- and gamma-wave count per second is measured. The derived values are compared. If the theta-, alpha- and gamma-wave count per second is stated to fall outside the values specific for high watchfulness, an EEG analyser converts a sequence of the values into a sensory signal and feeds a biofeedback-like warning signal automatically to state the control circuit logoff by the live operator.
EFFECT: method improves the accuracy of the control measurements enabling feeding the sensory signal in due time that is ensured by pre-determining a combination of highly-watchful EEG theta-, alpha- and gamma-wave frequencies.
1 dwg, 2 ex
SUBSTANCE: recent comatose condition is detected; magnetic resonance imaging shows centres of cerebral structural changes; electroencephalography shows epileptiform activity, diffuse sharp waves, spikes, reduced complexes, high-amplitude low activity paroxysmal events, frequent paroxysmal events of 'peak-slow wave' and 'spike-slow wave' complexes. The EEG also shows irritant activity, local transient high-frequency beta-activity, advanced transient low-amplitude and advance continuous long-term high-amplitude activity. The presence of an aetiological agent of the disease caused by tick-borne encephalitis or the presence of encephalitis of other and uncertain aetiology is stated. The derived data are scored depending on the presence, absence and manifestations thereof. The derived data are used to calculate linear classification functions and to detect the favourable (LCF1) outcome of encephalitis without symptomatic epilepsy (SE) progression and the unfavourable (LCF2) outcome of encephalitis with SE progression. If LCF1>LCF2, the encephalitis outcome without SE progression is predicted, while LCF2>LCF1 shows the unfavourable outcome with SE progression.
EFFECT: method provides more reliable assessment of the SE progression in encephalitis that is ensured by taking into account additional EEG data and calculating the linear classification functions.
SUBSTANCE: invention refers to medicine, namely to neonatology and neurology. During a 300-second slow sleep recording, transitory patterns are recovered on the EEG: frontal sharp waves of an average duration of 0.13 seconds, spike acute waves of an average duration of 0.045 seconds, high-amplitude PTӨ-waves of an average duration of 0.1 seconds, STOP-wave patterns of an average duration of 0.1 seconds. Indices (K) are calculated for each pattern in percentage, as a relation of the number of patterns of 300 seconds multiplied by its average duration to the recording duration (300 seconds). If K of the most patterns determined is less than 1, a physiologic norm is diagnosed; K falling within the range of 1-2 shows a moderate neurophysiologic immaturity; and if K is more than 2, major disturbances of the electrobiologic brain activity are stated.
EFFECT: method enables assessing the electrobiologic brain maturity of newborns of different gestational age that is ensured by determining and considering the transitory age-related patterns in the EEG.
4 dwg, 3 ex
SUBSTANCE: invention refers to medicine, namely to psychiatrics. In addition to the clinical study, an electroencephalography coherence analysis is conducted within the range of 30-45 Hz before psychotropic agents are prescribed. That is followed by determining middle zonal indices of the left and right hemispheres calculated between the midtemporal and following cortical regions: frontal, central, parietal, occipital, anteriofrontal and posteriofrontal in the homolateral direction. A hemispheric asymmetry factor (HAF) is calculated by dividing the middle zonal index of the left hemisphere by the middle zonal index of the right hemisphere. If the HAF value is less than 1, paranoid schizophrenia is diagnosed; and the value more than 1 shows schizo-affective disorder.
EFFECT: technique enables providing the more reliable differential diagnostics that is ensured by determining the zonal indices of the right and left hemispheres to calculate the hemispheric asymmetry factor.
SUBSTANCE: invention refers to medicine, namely to psychiatrics. A clinical examination is combined with recording an electroencephalogram (EEG); its spectral and coherent analyses are carried out. The following values are determined: T6-AA-lead power spectrum within the range of 3.5-5 Hz, F7-AA-lead power spectrum within the range of 2-3 Hz, T5-AA -lead power spectrum within the range of 23-24.5 Hz, hemispheric power asymmetry between F8-AA and F7-AA-leads within the range of 24.5-26 Hz, P4-C4-lead coherence within the range of 8-13 Hz, T4-F8 within the range of 23-24.5 Hz, T3-F7-lead power spectrum within the range of 26-27.5 Hz, T5-O1 within the range of 17-18.5 Hz, T3-F8 within the range of 20-21.5 Hz. Logarithms of the derived values are calculated. An integral diagnostic value is determined by mathematical formula taking into account the calculated logarithm and coefficient-corrective values. If the integral diagnostic value appears to be positive, a recurrent depressive disorder is diagnosed, while a bipolar affective disorder is shown by the negative integral diagnostic value.
EFFECT: method enables providing higher diagnostic reliability at the early stages of the disease that is ensured by the optimum selection of the values, and the mathematical calculation of the integral value.
FIELD: medicine, neurology, psychopathology, neurosurgery, neurophysiology, experimental neurobiology.
SUBSTANCE: one should simultaneously register electroencephalogram (EEG) to detect the level of constant potential (LCP). At LCP negativization and increased EEG power one should detect depolarizational activation of neurons and enhanced metabolism. At LCP negativization and decreased EEG power - depolarized inhibition of neurons and metabolism suppression. At LCP positivation and increased EEG power - either repolarized or hyperpolarized activation of neurons and enhanced metabolism. At LCP positivation and decreased EEG power - hyperpolarized suppression of neurons and decreased metabolism of nervous tissue. The method enables to correctly detect therapeutic tactics due to simultaneous LCP and EEG registration that enables to differentiate transition from one functional and metabolic state into another.
EFFECT: higher accuracy of diagnostics.
5 dwg, 1 ex, 1 tbl
FIELD: medicine, neurology.
SUBSTANCE: one should establish neurological status, bioelectric cerebral activity, availability of perinatal and ORL pathology in patients, establish their gradations and numerical values followed by calculation of prognostic coefficients F1 and F2 by the following formulas: F1=-31,42+1,49·a1-2,44·a2+0,2·а3+1,63·a4+0,62·а5+3,75·a6+1,8·а7-3,23·a8-0,8·а9-1,32·а10+3,26·а11+8,92·a12-2,0·a13+3,88·а14+1,79·a15+0,83·a16-2,78·a17; F2=-27,58+1,43·a1+3,31·а2+0,08·а3+3,05·а4-0,27·а5+2,69·а6+3,11·а7-6,47·a8-6,55·a9+1,99·а10+5,25·а11+7,07·a12-0,47·a13+0,13·a14+4,04·a15-1,0·a16-1,14·а17, correspondingly, where a1 - patient's age, a2 - studying either at the hospital or polyclinic, a3 - duration of stationary treatment (in days), a4 - unconscious period, a5 - terms of hospitalization since the moment of light close craniocerebral trauma, a6 - smoking, a7 - alcohol misuse, a8 - arterial hypertension, a9 - amnesia, a10 - close craniocerebral trauma in anamnesis, a11 - psychoemotional tension, a12 - meteolability, a13 - cervical osteochondrosis, a14 - ORL pathology, a15 - availability of perinatal trauma in anamnesis with pronounced hypertension-hydrocephalic syndrome, a16 - availability of paroxysmal activity, a17 - availability and manifestation value of dysfunction of diencephalic structures. At F1 ≥ F2 on should predict the development of remote aftereffects in young people due to evaluating premorbid background of a patients at the moment of trauma.
EFFECT: higher reliability of prediction.
2 ex, 1 tbl
FIELD: medicine; medical engineering.
SUBSTANCE: method involves doing multi-channel recording of electroencephalogram and carrying out functional tests. Recording and storing rheoencephalograms is carried out additionally with multi-channel recording of electroencephalogram synchronously and in real time mode in carotid and vertebral arteries. Electroencephalograms and rheoencephalograms are visualized in single window with single time axis. Functional brain state is evaluated from synchronous changes of electroencephalograms, rheoencephalograms and electrocardiograms in response to functional test. The device has electrode unit 1 for recording bioelectric brain activity signals, electrode unit 2 for recording electric cardiac activity signals, current and potential electrode unit 3 for recording rheosignals, leads commutator 4, current rheosignal oscillator 5, synchronous rheosignal detector 6, multi-channel bioelectric brain activity signals amplifier 7, electrophysiological signal amplifier 8, demultiplexer 9, multi-channel rheosignal amplifier 10, multi-channel analog-to-digital converter 11, micro-computer 12 having galvanically isolated input/output port and personal computer 13 of standard configuration.
EFFECT: enhanced effectiveness of differential diagnosis-making.
11 cl, 6 dwg
FIELD: medicine; medical engineering.
SUBSTANCE: method involves recording multichannel electroencephalogram, electrocardiogram record and carrying out functional test and computer analysis of electrophysiological signals synchronously with multichannel record of electroencephalogram and electrocardiogram in real time mode. Superslow brain activity is recorded, carotid and spinal artery pools rheoelectroencephalogram is recorded and photopletysmogram of fingers and/or toes is built and subelectrode resistance of electrodes for recording bioelectrical cerebral activity is measured. Physiological values of bioelectrical cerebral activity are calculated and visualized in integrated cardiac cycle time scale as absolute and relative values of alpha-activity, pathological slow wave activity in delta and theta wave bandwidth. Cerebral metabolism activity dynamics level values are calculated and visualized at constant potential level. Heart beat rate is determined from electrocardiogram, pulsating blood-filling of cerebral blood vessels are determined from rheological indices data. Peripheral blood vessel resistance level, peripheral blood vessel tonus are determined as peripheral photoplethysmogram pulsation amplitude, large blood vessel tonus is determined from pulse wave propagation time data beginning from Q-tooth signal of electrocardiogram to the beginning of systolic wave of peripheral photoplethysmogram. Postcapillary venular blood vessels tonus is determined from constant photoplethysmogram component. Functional brain state is determined from dynamic changes of physiological values before during and after the functional test. Device for evaluating functional brain state has in series connected multichannel analog-to-digital converter, microcomputer having galvanically isolated input/output ports and PC of standard configuration and electrode unit for reading bioelectric cerebral activity signals connected to multichannel bioelectric cerebral activity signals amplifier. Current and potential electrode unit for recording rheosignals, multichannel rheosignals amplifier, current rheosignals generator and synchronous rheosignals detector are available. The device additionally has two-frequency high precision current generator, master input of which is connected to microcomputer. The first output group is connected to working electrodes and the second one is connected to reference electrodes of electrode unit for reading bioelectrical cerebral activity signals. Lead switch is available with its first input group being connected to potential electrodes of current and potential electrodes unit for recording rheosignals. The second group of inputs is connected to outputs of current rheosignals oscillator. The first group of outputs is connected to current electrodes of current and potential electrodes unit for recording rheosignals. The second group of outputs is connected to inputs of synchronous detector of rheosignals. Demultiplexer input is connected to output of synchronous detector of rheosignals and its outputs are connected to multichannel rheosignals amplifier inputs. Outputs of multichannel bioelectrical cerebral activity signals amplifier, multichannel rheosignals amplifier and electrophysiological signal amplifier are connected to corresponding inputs of multichannel analog-to-digital converter. Microcomputer outputs are connected to control input of lead switch, control input of multichannel demultiplexer, control input of multichannel analog-to-digital converter and synchronization inputs of current rheosignals oscillator and synchronous detector of rheosignals. To measure subelectrode resistance, a signal from narrow bandwidth current generator of frequency f1 exceeding the upper frequency fup of signals under recording is supplied. A signal from narrow bandwidth current generator of frequency f2≠ f1>fup is supplied to reference electrode. Voltages are selected and measured at output of each amplifier with frequencies of f1, f2 - Uf1 and Uf2 using narrow bandwidth filtering. Subelectrode resistance of each working electrode is determined from formula Zj=Ujf1 :(Jf1xKj), where Zj is the subelectrode resistance of j-th electrode, Ujf1 is the voltage at output from j-th amplifier with frequency of f1, Kj is the amplification coefficient of the j-th amplifier. Subelectrode resistance of reference electrode is determined from formula ZA=Ujf2 :(Jf2xKj), where ZA is the subelectrode resistance of reference electrode, Ujf2 is the voltage at output from j-th amplifier with frequency of f2, Jf2 is the voltage of narrow bandwidth current oscillator with frequency of f2.
EFFECT: wide range of functional applications.
15 cl, 10 dwg
FIELD: medicine, psychiatry.
SUBSTANCE: one should conduct EEG-testing to detect total value of the indices of spectral power or percentage spectral power of delta- and teta-rhythms due to spectrometric technique in frontal, parietal, central and temporal areas both before and during emotional-negative loading when visual emotionally negative stimuli are presented followed by their imaginary reproduction. In case of higher indices to visual stimuli being above 15% against the background one should diagnose epilepsy. The method enables to increase the number of diagnostic means, increase accuracy and objectivity in predicting epilepsy with polymorphic paroxysms at dissociation of clinical and EEG-values.
EFFECT: higher efficiency of diagnostics.
1 ex, 1 tbl
FIELD: medicine, neurophysiology.
SUBSTANCE: one should carry out EEG survey to detect spectrometrically the index of full range if alpha-rhythm both before and after therapy. Moreover, power index of full range of alpha-rhythm and the index of 9-10 Hz-strip's spectral power should be detected in occipital cerebral areas. One should calculate the value of the ratio of the index of 9-10 Hz-strip's spectral power to the index of full range of alpha-rhythm and at the increase of this value by 20% against the background it is possible to evaluate positive result of therapy. The method increases the number of diagnostic means applied in evaluating therapeutic efficiency in the field of neurophysiology.
EFFECT: higher efficiency of evaluation.
FIELD: medicine, neurology.
SUBSTANCE: method involves carrying out the standard vascular and nootropic therapy. Diazepam is administrated under EEG control with the infusion rate that is calculated by the following formula: y = 0.0015x - 0.025 wherein y is the rate of diazepam administration, mg/h; x is an average EEG amplitude, mcV. Method provides enhancing the effectiveness of treatment of patients. Invention can be used for treatment of patients in critical severe period of ischemic insult.
EFFECT: enhanced effectiveness of treatment.
2 tbl, 1 dwg, 1 ex
SUBSTANCE: method involves selecting signals showing patient consciousness level and following evoked auditory potentials as responses to repeating acoustic stimuli, applying autoregression model with exogenous input signal and calculating AAI index showing anesthesia depth next to it.
EFFECT: quick tracing of unconscious to conscious state and vice versa; high accuracy of measurements.
9 cl, 3 dwg
FIELD: medicine; experimental and medicinal physiology.
SUBSTANCE: device can be used for controlling changes in functional condition of central nervous system. Device has receiving electrodes, unit for reading electroencephalograms out, analog-to-digital converter and inductor. Low noise amplifier, narrow band filter linear array which can be program-tuned, sample and store unit, online memory, microcontroller provided with controlled permanent storage, liquid-crystal indicator provided with external control unit are introduced into device additionally. Receiving electrodes are fastened to top part of patient's head. Outputs of electrodes are connected with narrow band filters linear array through electroencephalograph. Output of linear array is connected with input of input unit which has output connected with input of analog-to-digital converter. First bus of analog-to-digital converter is connected with online storage. Recording/reading bus of microcontroller is connected with control input of input unit and its starting bus is connected with address input of online storage. Third control bus is connected with narrow band filters linear array. Second control bus is connected with liquid-crystal indicator. Output bus is connected with inductor. External control (keyboard) of first control bus is connected with microcontroller. Output of online storage is connected with data input of microcontroller through 12-digit second data bus. Efficiency of influence is improved due to getting specific directed influence being based onto general technological transparency of processing of human brain's signals and strictly specific influence based on the condition of better stimulation.
EFFECT: increased efficiency.
3 cl, 1 dwg, 1 tbl
FIELD: medicine, neurology, professional pathology.
SUBSTANCE: one should carry out either biochemical blood testing and electroencephalography or SMIL test, or ultrasound dopplerography of the main cranial arteries, rheoencephalography (REG) to detect the volume of cerebral circulation and hypercapnic loading and their digital values. Then it is necessary to calculate diagnostic coefficients F by the following formulas: Fb/e=6.3-0.16·a1+0.12·a2-1·a3+0.2·a4, or FSMIL=9.6+0.16·a5-0.11·a6-0.14·a7+0.07·a8, or Fhem=48.6-0.04·a9+0.15·a10+13.7·a11-0.02·a12+24.7·a13, where Fb/e -diagnostic coefficient for biochemical blood testings and EEG; FSMIL - diagnostic coefficient for SMIL test; Fhem - diagnostic coefficient for hemodynamic testing; 6.3; 9.6 and 48.6 - constants; a1 - the level of vitamin C in blood; a2 - δ-index by EEG; a3 - atherogenicity index; a4 - the level of α-proteides in blood; a5 - scale 3 value by SMIL; a6 - scale K value by SMIL; a7 - scale 5 value by SMIL; a8 - scale 7 value by SMIL; a9 - the level of volumetric cerebral circulation; a10 - the value of linear circulatory rate along total carotid artery, a11 - the value of resistive index along total carotid artery; a12 - the value for the tonicity of cerebral vessels at carrying out hypercapnic sampling by REG; a13 - the value for the intensity of cerebral circulation in frontal-mastoid deviation by REG. At F value being above the constant one should diagnose toxic encephalopathy, at F value being below the constant - discirculatory encephalopathy due to applying informative values.
EFFECT: higher accuracy of diagnostics.
6 ex, 1 tbl