Compositions containing basic amino acid and soluble carbonate salt

FIELD: medicine, pharmaceutics.

SUBSTANCE: group of inventions refers to an oral care composition, methods for preparing and using it. The presented composition containing a pre-mix containing arginine in the free form or in the form of a salt, a soluble carbonate salt and arginine bicarbonate formed in situ when mixing arginine in the free form or in the form of a salt with the soluble carbonate salt. The method for preparing the composition involves preparing the pre-mix by mixing arginine in the free form or in the form of the salt and soluble carbonate salt. What is also presented is an oral care procedure involving coating the patient's oral cavity with an effective amount of the above composition.

EFFECT: using the group of inventions provides positive effects achieved by using the oral care composition containing arginine bicarbonate in a combination with a simplified process of preparation of this composition.

15 cl, 2 ex

 

The present application claims the priority of patent application United States serial No. 61/027424, filed February 8, 2008, the content of which is incorporated into this description by reference.

PRIOR art INVENTIONS

Arginine and other basic amino acids are proposed for use in the care of the oral cavity and believe they have significant advantages in the fight against cavities and tooth sensitivity. Commercially available toothpaste based on arginine, such as ProClude® or DenClude®, for example, contains arginine bicarbonate; however, such salts are expensive.

The arginine bicarbonate is produced by gas sparging carbon dioxide through a saturated aqueous solution of arginine. However, the effectiveness of the existing process needs to be improved. First, the existing process is slow, requires 24 to 48 hours to complete the reaction. Secondly, carbon dioxide has a very limited solubility in water, and the solution reaches a maximum concentration of approximately 1.2×10-5M at room temperature and normal partial pressure of carbon dioxide. Third, the solubility of arginine in water is only about 15% mass/mass at room temperature. Obtaining a concentrated solution of arginine bicarbonate (for example, p� least 40%) requires the addition to the solution of arginine, thereby increasing production time and requires constant monitoring responses.

Therefore, it is desirable to develop compositions and formulations, which have useful benefits of arginine by reducing the cost of the ingredients.

A BRIEF summary of the INVENTION

The invention encompasses a composition for caring for the oral cavity and methods of use thereof, which are effective in inhibiting or reducing the accumulation of plaque, reducing bacteria, acid producing (cariogenic), the remineralization of teeth and inhibition or reduction of gingivitis. The invention also encompasses compositions and methods for cleaning the oral cavity and provides ways to support the health of the mouth and/or General health, including the cardiovascular system, for example, reducing the possibility of systemic infection via the oral tissues.

Therefore, the invention includes a compound of 1.0, the composition for caring for the oral cavity, such as a dentifrice containing a basic amino acid, e.g., arginine, in free form or in salt form, e.g., arginine hydrochloride, together with a soluble carbonate salt, such as sodium carbonate, sodium bicarbonate or a mixture thereof, where the bicarbonate basic amino acid is formed in situ.

"Soluble bicarbonate salt" refers to any soluble salt formed by carbonic acid or dissolved silica. In aqueous solution, carbonate ion, bicarbonate ion, carbon dioxide and carbonic acid to form a dynamic equilibrium. Therefore, the term "carbonate" as used in the present description, covers form bicarbonate (HCO3-) and carbonate (CO32-), and mixtures thereof. Consequently, soluble carbonate salts include, for example, potassium carbonate, potassium bicarbonate, sodium carbonate and sodium bicarbonate.

"On the spot" means that the bicarbonate salt of the basic amino acid is formed in the composition.

Therefore, the composition is 1.0 contains, for example, any of the following songs:

1.0.1. The composition is 1.0, where the basic amino acid is arginine, lysine, citrulline, ornithine, creatine, histidine, diaminobutane acid, diaminopropionic acid their salts and/or combination.

1.0.2. Composition 1.0 or 1.0.1, where the basic amino acid has the L-configuration.

1.0.3. Any of the preceding compositions, where the basic amino acid is arginine.

1.0.4. Any of the preceding compositions, where the basic amino acid is L-arginine.

1.0.5. Any of the preceding compositions, where the basic amino acid source provide and partially�and completely in salt form.

1.0.6. Composition 1.0.5, where the basic amino acid source to provide receptionarea in the form of arginine hydrochloride.

1.0.7. Any of the preceding compositions, where the soluble carbonate salt is a sodium bicarbonate.

1.0.8. Any of the preceding compositions, where the basic amino acid is present in an amount corresponding to from about 0.1 to about 20%, e.g., from about 1 wt.% to about 10 wt.% the total weight of the composition, the weight of the basic amino acid is calculated in free base form.

1.0.9. Composition 1.0.8, where the basic amino acid is present in an amount of from approximately 1.5 to approximately 3,75, about 5 or about 7.5 wt.% the total weight of the composition.

1.0.10. Any of the preceding compositions containing a source of fluoride, for example, where the fluoride is covalently bonded to another atom, for example, selected from the fluorophosphates, for example, sodium monofluorophosphate, fertilisation, for example, forcricket sodium, forcricket ammonium and persulfates, for example, hexapetala and combinations thereof.

1.0.11. Composition 1.0.10, where the fluoride salt is sodium monofluorophosphate.

1.0.12. Any of the preceding compositions wherein the salt of fluoride is present in an amount of from about 0.01 wt.% to about 2 wt.% the total weight of the composition.

1.0.13. Any of the preceding compositions, where the fluoride salt provides fluoride ions in an amount of from about 0.1 to about 0.2 wt.% the total weight of the composition.

1.0.14. Any of the preceding compositions, where the soluble fluoride salt provides fluoride ions in an amount of from about 50 to about 25,000 ppm.

1.0.15. Any of the preceding compositions which is a dentifrice, having from about 750 to about 2000 ppm of available fluoride ion.

1.0.16. Any of the preceding compositions, where the composition includes from about 1000 to about 1500 ppm of fluoride ions.

1.0.17. Any of the preceding compositions, where the composition includes approximately 1450 ppm of fluoride ions.

1.0.18. Any of the preceding compositions where the pH is from about 6 to about 9.

1.0.19. Any of the preceding compositions where the pH is from about 8 to about 9.

1.0.20. Any of the preceding compositions further comprising an abrasive material or particles.

1.0.21. Immediately preceding the composition, where the abrasive or particulate is selected from sodium bicarbonate, calcium phosphate (e.g., dihydrate dicalcium phosphate), calcium sulphate, calcium carbonate, hydroxyapatite, precipitated calcium carbonate, silicon dioxide� (for example, hydrated silicon hydroxide), iron oxide, aluminum oxide, perlite, plastic particles, e.g., polyethylene and combinations thereof.

1.0.22. Immediately preceding the composition, where the abrasive or particulate is selected from calcium carbonate, silica (e.g., hydrated silica), and combinations thereof.

1.0.23. Any of the preceding compositions comprising an abrasive in an amount of from about 15 wt.% to about 70 wt.% the total weight of the composition.

1.0.24. Any of the preceding compositions comprising abrasive fraction of small particles is at least about 5%, having a d50 of approximately less than approximately 5 micrometers.

1.0.25. Any of the preceding compositions having a RDA of less than about 150, for example, from about 40 to about 140.

1.0.26. Any of the preceding compositions comprising an anionic surfactant.

1.0.27. Any of the preceding compositions, where the anionic surfactant is selected from sodium lauryl sulfate, sodium lauryl sulfate ether and mixtures thereof.

1.0.28. Any of the preceding compositions, where the anionic surfactant is present in an amount of from about 0.3 to about 4.5 wt.%.

1.0.29. Any of the preceding compositions comprising surface-�active substances, selected from anionic, cationic, zwitterionic and nonionic surfactants and mixtures thereof.

1.0.30. Any of the preceding compositions comprising at least one moisturizer.

1.0.31. Any of the preceding compositions comprising at least one humectant, for example, polyol, for example, selected from glycerol, sugar alcohols (e.g. sorbitol, xylitol and combinations thereof.

1.0.32. Any of the preceding compositions comprising xylitol.

1.0.33. Any of the preceding compositions comprising at least one polymer.

1.0.34. Any of the preceding compositions comprising at least one polymer selected from polyethylene glycols, copolymers polivinilovogo ether and maleic acid, polysaccharides (e.g., cellulose derivatives, e.g., carboxymethyl cellulose, or polysaccharide gums, for example xanthan gum or carraginanous gum), and combinations thereof.

1.0.35. Any of the preceding compositions comprising strips or pieces of gum.

1.0.36. Any of the preceding compositions comprising a flavouring substance, flavouring and/or colorant.

1.0.37. Any of the preceding compositions comprising water.

1.0.38. Any of the preceding compositions comprising an antibacterial agent selected from halogenated diphenyl ether (n�example, triclosan), herbal extracts and essential oils (e.g. rosemary extract, tea extract, Magnolia extract, thymol, menthol, eucalyptol, geraniol, carvacrol, citral, honokiol, catechol, methyl salicylate, epigallocatechin gallate, epigallocatechin, Gallic acid, miswak extract, sea buckthorn extract kruchininoj), biguanide antiseptics (e.g., chlorhexidine, alexidine or octenidine), Quaternary ammonium compounds (e.g., chloride cetylpyridinium (CPC), benzalkonium chloride, chloride of tetradecylbenzene (TRS), chloride N-tetradecyl-4-ethylpyridine (TDEPC)), phenolic antiseptics, hexetidine treatment, octenidine, sanguinarine, povidone iodine, delmopinol, califlour, metal ions (e.g., zinc salts, e.g. zinc citrate, salts of tin, copper salts, iron salts), sanguinarine, propolis and oxidizing agents (e.g. hydrogen peroxide, buffer peroxyborate or peroksikarbonat), talavou acid and its salts, monopetalum acid and its salts and esters, ascorbinsaeure, oleoresin, alkylsulfate, dioctylsulfosuccinate, salicylanilide, domainbased, delmopinol, Octafinal and other piperidine derivatives, preparations Nizina, salts of chlorite and mixtures of any of the foregoing.

1.0.39. Any of the preceding compositions comprising an anti-inflammatory compound, e.g., an inhibitor of at mariodragon of proinflammatory factors, selected from matrix metalloproteinases (MMP), cyclooxygenase (COX), PGE2, interleukin I (IL-I), IL-Iβ-converting enzyme (ICE), transforming growth factor β1 (TGF-β1), inducible synthase nitric oxide (iNOS), hyaluronidase, in vitro, nuclear factor Kappa B (NF-κB) and kinases associated with the receptor of IL-1 (IRAK), for example, selected from aspirin, Ketorolac, flurbiprofen, ibuprofen, naproxen, indomethacin, aspirin, Ketoprofen, piroxicam, meclofenamic acid, nordihydroguaiaretic acid and mixtures thereof.

1.0.40. Any of the preceding compositions comprising an antioxidant, e.g., selected from co-enzyme Q10, PQQ, vitamin C, vitamin A, retalitation and mixtures thereof.

1.0.41. Any of the preceding compositions comprising triclosan.

1.0.42. Any of the preceding compositions comprising triclosan and a source of ions of Zn2+for example , zinc citrate.

1.0.43. Any of the preceding compositions comprising triclosan and xylitol.

1.0.44. Any of the preceding compositions comprising triclosan, xylitol, and precipitated calcium carbonate.

1.0.45. Any of the preceding compositions including sorbitol and chitosan.

1.0.46. Any of the preceding compositions comprising an anti-Tartar deposits.

1.0.47. Any of the preceding compositions further comprising means p�of otiv Tartar deposits, which is a polyphosphate, e.g., pyrophosphate, tripolyphosphate or hexametaphosphate, for example, in the form of sodium salt.

1.0.48. Any of the preceding compositions comprising an antibacterial agent in an amount of from approximately 0.01 to approximately 5 wt.% the total weight of the composition.

1.0.49. Any of the preceding compositions comprising triclosan in an amount of from about 0.01 to about 1 wt.% the total weight of the composition.

1.0.50. Any of the preceding compositions comprising triclosan in an amount of about 0.3% of the total weight of the composition.

1.0.51. Any of the preceding compositions comprising a bleaching agent.

1.0.52. Any of the preceding compositions comprising a bleaching agent selected from a whitening active ingredient selected from the group consisting of peroxides, metal chlorite, perborates, percarbonates, peroxyketal, hypochlorite, and combinations thereof.

1.0.53. Any of the preceding compositions further comprising hydrogen peroxide or a source of hydrogen peroxide, for example, urea peroxide, or salts or complexes of peroxide (e.g., such as the salt proxyport, peroxocarbonate, perborate, peroxisomal or persulfate; for example, proxyport calcium, sodium perborate, peroksikarbonat, peroxyborate sodium and Persian�that potassium) or polymeric complexes of hydrogen peroxide, such as polymeric complexes of hydrogen peroxide-polyvinylpyrrolidone.

1.0.54. Any of the preceding compositions further comprising an agent that affects or prevents the attachment of bacteria, for example Cabral or chitosan.

1.0.55. Any of the preceding compositions further comprising a source of calcium and phosphate selected from (i) complex calcium glass, for example, phosphosilicate sodium and (ii) complexes of calcium-protein, for example, phosphopeptide casein-amorphous calcium phosphate.

1.0.56. Any of the preceding compositions further comprising a soluble calcium salt, e.g., selected from calcium sulfate, calcium chloride, calcium nitrate, calcium acetate, calcium lactate, and combinations thereof.

1.0.57. Any of the preceding compositions further comprising a physiologically acceptable potassium salt, e.g., potassium nitrate or potassium chloride, in amounts effective to reduce the sensitivity of dentin.

1.0.58. Any of the preceding compositions comprising from about 0.1% to about 7.5% of a physiologically acceptable potassium salt, e.g., calcium nitrate or potassium chloride.

1.0.59. Any of the preceding compositions which is a toothpaste comprising triclosan; an anionic surfactant and/or a compatible solution�the MUI fluoride salt, for example sodium monofluorophosphate.

1.0.60. Any of the preceding compositions effective upon application to the oral cavity, for example, when brushing, to (i) reduce or inhibit formation of dental caries, (ii) reduce, repair or inhibit precariously lesions of the enamel, for example, that determine quantitative light-induced fluorescence (QLF) or electrical rating of caries (ECM), (iii) reduce or inhibit demineralization and providing remineralization of the teeth, (iv) reduce hypersensitivity of the teeth, (v) reduce or inhibit gingivitis, (vi) maintenance of healing of wounds or cuts in the mouth, (vii) reduce levels of bacteria that produce acid, (viii) to increase relative levels alginolyticus bacteria, (ix) inhibition of formation of biofilms in the oral cavity, (x) raise and/or maintain the pH of plaque at the level of at least pH 5.5 after a sugar load, (xi) reduce plaque accumulation, (xii) treat, relieve or reduce dry mouth, (xiii) clean the teeth and oral cavity (xiv) reduce erosion, (xv) whiten teeth, (xvi) immunize the teeth against cariogenic bacteria; and/or (xvii) maintain system health, including the cardiovascular system, for example, reducing the possibility of systemic infection via the oral tissues.

p> 1.0.61. The composition is obtained or obtainable by mixing the ingredients as specified in any of the preceding compositions.

1.0.62. Any of the preceding compositions in the form selected from the rinse to the mouth, toothpaste, tooth gel, tooth powder, non-abrasive gel, mousse, foam, spray, mouthwash, lozenge, oral tablet, dental instruments and products for pet care.

1.0.63. Any of the preceding compositions, where the composition is a toothpaste.

1.0.64. Any of the preceding compositions, where the composition is a toothpaste optionally further comprising one or more of one or more of water, abrasives, surfactants, foaming agents, vitamins, polymers, enzymes, humectants, thickeners, antimicrobial agents, preservatives, flavorings, colorings and/or combinations thereof.

1.0.65. Any of the preceding compositions 1.0-1.0.61, where the composition is a rinse for the mouth.

1.0.66. Any of the preceding compositions further comprising mouthwash, perfume or flavoring.

1.0.67. Any of the preceding compositions obtained by the method according to method 2.0-2.5.

The present invention also encompasses a method 2.0, a method of obtaining a composition for caring for the oral cavity include�s mixing basic amino acid in free form or in salt form, and carbonate salts. Optionally, the composition may be brought to a pH of from about 8.5 to about 9.5 in. Furthermore, additional materials may be mixed with the composition to obtain a composition for caring for the oral cavity, for example, in accordance with any one of compositions 1.0-1.0.61 above.

Therefore, the 2.0 includes, for example, the following variants of the invention:

2.1 Method 2.0, where the carbonate salt is selected from sodium carbonate and sodium bicarbonate.

2.2. Method 2.0 or 2.1, where the basic amino acid selected from arginine, lysine, citrulline, ornithine, creatine, histidine, diaminobutane acid, diaminopropionic acid, in free form or salt form and/or combination.

2.3 Method 2.2, where the basic amino acid is arginine.

2.4 Method 2.3, where arginine is in the form selected from the free base, hydroxide, hydrochloride and mixtures thereof.

2.5 Any of the previous methods, where the premix is adjusted to approximately pH 9.

Therefore, the invention further contemplates methods (method 3) to (i) reduce or inhibit formation of dental caries, (ii) reduce, repair or inhibit pre-carious lesions of the enamel, for example, that were determined by quantitative light-induced fluorescence (QLF) or electrical rating of caries (ECM), (iii) reduce reingenieria demineralization and providing remineralization of the teeth, (iv) reduce hypersensitivity of the teeth, (v) reduce or inhibit gingivitis, (vi) maintenance of healing of wounds or cuts in the mouth, (vii) reduce levels of bacteria that produce acid, (viii) to increase relative levels alginolyticus bacteria, (ix) inhibition of formation of biofilms in the oral cavity, (x) raise and/or maintain the pH of plaque at the level of at least pH 5.5 after a sugar load, (xi) reduce plaque accumulation, (xii) treat, relieve or reduce dry mouth, (xiii) clean the teeth and oral cavity (xiv) reduce erosion, (xv) whiten teeth, (xvi) immunize the teeth against cariogenic bacteria; and/or (xvii) maintain system health, including the cardiovascular system, for example, reducing the possibility of systemic infection via the oral tissues, comprising applying the composition according to the invention in the oral cavity, for example, applying the composition of the invention into the oral cavity of a patient in need.

The invention further includes the use of basic amino acids, e.g., arginine, in obtaining the compositions according to the invention, for example, in accordance with any means of method 2, or for use in any of the indications referred to in method 3.

Therefore, an experienced professional in the field of technology care for the oral cavity mo�em to be marked, what can be achieved unexpected technical effect and advantage of the formation of bicarbonate salts of basic amino acids such as arginine, in place of the composition for the care of the oral cavity, by reaction of a precursor of bicarbonate and predecessor basic amino acids in the composition, among other things, it will be possible to dispense with such a relatively expensive commercially available bicarbonate salts of basic amino acids without reducing enhanced treatment of dentine provided by arginine.

DETAILED description of the INVENTION

Without communication with theory believe that the composition for caring for the oral cavity comprising arginine bicarbonate, for example, anions of arginine and bicarbonate can be formed by the addition of the free base arginine and carbonate salts, e.g. sodium bicarbonate and sodium carbonate. The use of such materials is beneficial due to the use of arginine bicarbonate, as the free base arginine and carbonate salts are substantially cheaper as the initial substance than sodium bicarbonate.

Essential amino acids that can be used in the compositions and methods of the invention include not only natural basic amino acids such as arginine, lysine, and histidine, but also any basic amino acids having in the molecule� carboxyl group and an amino group. Accordingly, basic amino acids include, but are not limited to, arginine, lysine, citrulline, ornithine, creatine, histidine, diaminobutane acid, diaminopropionic acid, their salts or their combinations. In a particular embodiment, the basic amino acid selected from arginine, citrulline and ornithine. In certain embodiments, the basic amino acid is arginine, such as l-arginine, or its salt.

In various embodiments, the basic amino acid is present in amounts from about 0.1 wt.% to about 20 wt.% the total weight of the composition, from about 1 wt.% to about 10 wt.% the total weight of the composition, for example, from about 1.5 wt.% to approximately of 3.75 wt.%, approximately 5 wt.% or about 7.5 wt.% the total weight of the composition.

Compositions for caring for the oral cavity may further include one or more sources of fluoride ions, such as fluoride salts, which may be soluble. To enhance compatibility, preferred are salts of fluoride where fluoride is covalently bonded to another atom and/or is separated from the calcium. A wide variety of materials, giving the fluoride ions may be used as sources of soluble fluoride in the present compositions. Examples of eligible�x materials giving fluoride ions, are found in U.S. patent No. 5353421 issued by Briner et al., U.S. patent No. 4885155 issued to Parran Jr. Et al. and U.S. patent No. 3678154 issued to Widder et al., included in this description by reference.

Typical sources of fluoride ions include, but are not limited to, tin fluoride, sodium fluoride, potassium fluoride, sodium monofluorophosphate, forcricket sodium, forcricket ammonium, amine fluoride, ammonium fluoride, and combinations thereof. In certain embodiments the fluoride ion source includes tin fluoride, sodium fluoride, sodium monofluorophosphate, and mixtures thereof.

In certain embodiments, the composition for caring for the oral cavity according to the invention can also contain a source of fluoride ions or ingredient that provides fluorine in amounts sufficient to supply from about 25 ppm to 25,000 ppm of fluoride ions, generally at least about 500 ppm, e.g., from about 500 to about 2000 ppm, e.g., from about 1000 to about 1600 ppm, e.g., about 1450 ppm. Appropriate level of fluoride will depend on the particular application. Rinse to the mouth, for example, will typically contain from about 100 to about 250 ppm fluoride. Toothpaste to use basic potrebitelskie will contain from about 1000 to about 1500 ppm, pediatric toothpaste is slightly less. The dentifrice or coating for professional application can contain as many as 5000 or even 25000 ppm of fluoride.

The sources of fluoride ions may be added to compositions according to the invention at a level of from about 0.01 wt.% to about 10 wt.% in one embodiment, or from about 0.03 wt.% to about 5 wt.% or in another embodiment, from about 0.1 wt.% to about 1 wt.% by weight of the composition in another embodiment of the invention. The mass of the fluoride salts to provide the appropriate level of fluoride ion will obviously vary based on the weight of the counterion in the salt.

The composition of the invention may include the abrasive on the basis of calcium phosphate, for example, phosphate tricalysia (Ca(PO4)2), hydroxyapatite (Ca10(PO4)6(OH)2) or the dihydrate of calcium phosphate (CaHPO4· 2H2Oh, also sometimes referred to in the present description as DiCal) or calcium pyrophosphate.

The compositions can include one or more additional abrasives, abrasives for example based on silica, such as precipitated silica, having an average particle size of approximately 20 microns, such as Zeodent 115®, marketed by J. M. Huber. Other approx�nimāi abrasives also include sodium metaphosphate, the potassium metaphosphate, aluminum silicate, calcined alum, bentonite or other siliceous materials, or combinations thereof.

Abrasive polishing materials based on silicon dioxide, which is applicable in the present description, as well as other abrasives, generally have an average particle size of from about 0.1 to about 30 microns, from about 5 to about 15 microns. Abrasives silicon-based can be from precipitated silica or silica gels, such as xerogels of silicon dioxide, as described in U.S. patent No. 3538230 issued to Pader et al., and U.S. patent No. 3862307 issued by Digiulio, both included in this description by reference. Certain xerogels of silicon dioxide are available on the market under the trade name Syloid® from W. R. Grace & Co., Davison Chemical Division. Materials precipitated silica include those sold by J. M. Huber Corp. under the trade name Zeodent®, including the silica carrying the designation Zeodent 115 and 119. Such abrasives on the basis of silicon dioxide is described in U.S. patent No. 4340583 issued Wason included in this description by reference.

In certain embodiments, abrasive materials, applicable in the implementation of the compositions for the care of the oral cavity in accordance with the invention include silica gels and precipitated amorphous silica having a value �of alapalooza approximately less than 100 CC/100 g silica and in the range of about 45 CC/100 g to about 70 CC/100 g silica. The values of Malopolskie was measured using ASTA Rub-Out Method D281. In certain embodiments, the silica are colloidal particles having an average particle size from about 3 microns to about 12 microns, and from about 5 microns to about 10 microns.

In certain embodiments, the abrasive materials comprise a large fraction of very small particles, e.g., having a d50 less than about 5 microns, for example, small particle silica (SPS) having a d50 of about 3 to about 4 microns, for example Sorbosil AC43® (Ineos). Such small particles are particularly useful in compositions designed to reduce hypersensitivity. Component fine particles may be present in combination with a second abrasive material with larger particles. In certain embodiments, for example, the composition includes from about 3 to about 8% SPS and from about 25 to about 45% of a conventional abrasive.

Abrasives on the basis of silicon dioxide with a low Malopolskie, especially applicable in the practice of the invention are sold under the trade designation Sylodent XWA® Davison Chemical Division of W. R. Grace & Co., Baltimore, Md. 21203. Sylodent 650 XWA®, a hydrogel of silica, comprising particles of colloidal �of oxida silicon, having a water content of about 29 wt.%, on average from about 7 to about 10 microns in diameter and Malopolskie less than about 70 CC/100 g of silicon dioxide, is an example of abrasives on the basis of silicon dioxide with a low Malopolskie applicable in the implementation of the present invention. The abrasive is present in a composition for caring for the oral cavity according to the present invention in a concentration of from about 10 to about 60 wt.%, in another embodiment, from about 20 to about 45 wt.% in another embodiment, from about 30 to about 50 wt.%.

Compositions for caring for the oral cavity according to the invention may also include means for increasing the amount of foam that is formed during the cleaning of the oral cavity.

Illustrative examples of means that increase the amount of foam include, but are not limited to, polyoxyethylene and specific examples, including but not limited to, alginate polymers.

Polyoxyethylene can increase the amount of foam and the thickness of the foam formed by the component carrier to care for the oral cavity according to the present invention. Polyoxyethylene also commonly known as polyethylene glycol ("PEG") or polyethylene oxide. Polyoxyethylene suitable for the present Fig�plants, have a molecular weight from about 200,000 to about 7000000. In one embodiment the molecular weight is from about 600,000 to about 2000000 and in another embodiment from about to about 80000 1000000. Polyox® is the trade name for high molecular polyoxyethylene produced by Union Carbide.

Polyoxyethylene may be present in an amount of from about 1% to about 90%, in one embodiment, from about 5% to about 50% and in another embodiment from about 10% to about 20% by weight of the component carrier to care for the oral cavity compositions for caring for the oral cavity according to the present invention. The dosage of the foaming means in a composition for caring for the oral cavity (i.e., single dose) ranges from about 0.01 to about 0.9 wt.%, from about 0.05 to about 0.5 wt.% in another embodiment, from about 0.1 to about 0.2 wt.%.

Other means, not necessarily included in a composition for caring for the oral cavity according to the invention, is a surface-active agent or mixture of compatible surfactants. Suitable surface-active �of exista are these, which are reasonably stable throughout a wide pH range, for example, anionic, cationic, nonionic or zwitterionic surfactants.

Suitable surfactants are described more fully, for example, in U.S. patent No. 3959458 issued by Agricola et al., U.S. patent No. 3937807 issued to Haefele; and U.S. patent No. 4051234 issued by Gieske et al., included in this description by reference.

In certain embodiments, anionic surface-active substances, applicable in the present description, include water-soluble salts of alkylsulfates having from about 10 to about 18 carbon atoms in the alkyl radical and the water-soluble salts of sulfonated monoglycerides of fatty acids having from about 10 to about 18 carbon atoms. Sodium lauryl sulfate, lauroylsarcosine sodium sulfonates coconut monoglyceride sodium are examples of anionic surfactants of this type. Mixtures of anionic surfactants can also be used.

In another embodiment the cationic surface-active substances, applicable in the present invention can be broadly defined as derivatives of aliphatic Quaternary ammonium compounds having one long�Yu alkyl chain, containing from about 8 to about 18 carbon atoms, such as chloride of lauryldimethylamine, chloride of cetylpyridinium, bromide, cetyltrimethylammonium, chloride of , nitrite coconut alkyltrimethylammonium, fluoride cetylpyridinium and mixtures thereof.

Illustrative cationic surfactants are the Quaternary ammonium fluorides described in U.S. patent No. 3535421 issued by Briner et al., included in this description by reference. Certain cationic surfactants can also act in the compositions as germicides.

Illustrative nonionic surfactants that can be used in the compositions according to the invention, can be broadly defined as compounds obtained by condensation alkalinising groups (hydrophilic in nature) with an organic hydrophobic compound which may be aliphatic or alkyl in nature. Examples of suitable nonionic surfactants include, but are not limited to, Pluronics, polyethylenoxide condensates of alkyl phenols, products derived from the condensation of ethylene oxide with the reaction product of propylene oxide and ethylene diamine, ethyleneoxide condensates of aliphatic alcohols, long chain tertiary amine oxides, long�chain tertiary phosphine oxides, the long-chain diallylsulfide and mixtures of such materials.

In certain embodiments, zwitterionic synthetic surface-active substances, applicable in the present invention can be broadly described as derivatives of aliphatic Quaternary ammonium compounds, phosphonium and sulfone in which the aliphatic radicals can be linear chain or branched and where one of the aliphatic substituents contains from about 8 to about 18 carbon atoms and one contains an anionic water-soluble group, e.g., carboxy, sulfonate, sulfate, phosphate or phosphonate. Illustrative examples of surfactants suitable for inclusion in the composition include, but are not limited to, alkylsulfate sodium, lauroylsarcosine sodium, cocamidopropylbetaine and Polysorbate 20, and combinations thereof.

In a specific embodiment, the composition according to the invention includes an anionic surfactant, such as sodium lauryl sulfate.

A surfactant or mixture of compatible surfactants can be present in compositions of the present invention in an amount of from approximately 0.1% to approximately 5.0 percent, in another embodiment from about 0.3% to priblizitel�but 3.0% and in another embodiment from about 0.5% to approximately 2.0% by weight of the total composition.

Compositions for caring for the oral cavity according to the invention can also include a flavoring agent. Flavouring tools, which are used in the implementation of the present invention include, but are not limited to, essential oils as well as various flavoring aldehydes, esters, alcohols, and similar materials. Examples of essential oils include oil curly mint, peppermint, Wintergreen, sassafras, clove, sage, eucalyptus, marjoram, cinnamon, lemon, lime, grapefruit and orange. Also applicable are such chemicals as menthol, carvone, and anethole. In certain embodiments, use of peppermint oil and mint crispy.

Flavoring means include in a composition for caring for the oral cavity in a concentration of from about 0.1 to about 5 wt.% and from about 0.5 to about 1.5 wt.%. The dosage of flavoring means in the dosage of compositions for personal care for the oral cavity (i.e., single dose) ranges from about 0.001 to about 0.05% by weight and in another embodiment from about 0.005 to about of 0.015 wt.%.

Compositions for caring for the oral cavity according to the invention may also optionally include one or more complexing means capable images�VAT complex with calcium, found in the cell wall of bacteria. The binding of such calcium weakens the bacterial wall and facilitates the lysis of bacteria.

Another group of tools suitable for use as complexing means in the present invention is a soluble pyrophosphates. Pyrophosphate salts, applicable in the present compositions can be any pyrophosphate alkali metal salts. In certain embodiments, salts include pyrophosphate tetralone metals, likely pyrophosphate displacing metals, monocyclic pyrophosphate timelocked metals and mixtures thereof, where the alkali metals are sodium or potassium. Salts are applicable and in hydrated and non hydrated forms. An effective amount of pyrophosphate salts, applicable in the present composition is generally enough to provide at least about 1 wt.% pyrophosphate ions, about 1.5 wt.% to about 6 wt.%, from about 3.5 wt.% to about 6 wt.% such ions.

Compositions for caring for the oral cavity according to the invention also optionally include one or more polymers, such as polyethylene glycols, copolymers polivinilovogo ether and maleic acid, polysaccharides (e.g., cellulose derivatives, for example, Carbo�emailclose or polysaccharide gums, for example, xanthan gum or karragenana gum). Acidic polymers, such as polyacrylate gels, can be represented in the form of their free acids or partially or fully neutralized water soluble alkali metal salts (e.g. potassium or sodium) or ammonium. Certain embodiments of the invention include from about 1:4 to about 4:1 copolymers of maleic anhydride or acid with another polymerizable ethylene-unsaturated monomer, for example, methyl vinyl ether (maoxicillin) having a molecular mass (MM) of from about 30,000 to about 1000000. Such copolymers are available, for example as Gantrez AN 139 (MM OF 500,000), AN 119 (MM 250000) and S-97 pharmaceutical grade (MM 70000), of GAF Chemicals Corporation.

Other used polymers such as copolymers of 1:1 maleic anhydride with acrylate, hydroxyethylmethacrylate, N-vinyl-2-pyrrolidone, or ethylene, the latter is available, for example, as Monsanto EMA No. 1103, 10000 MM and the EMA grade 61, and 1:1 copolymers of acrylic acid with methyl or hydroxyethylmethacrylate, methyl or ethyl, isobutylphenyl ether or N-vinyl-2-pyrrolidone.

Typically suitable are polymerized olefin or Ethylenediamine carboxylic acids containing an activated olefinic double bond of carbon-carbon and less� least one carboxyl group, for example, an acid containing an olefinic double bond, which is easily participates in polymerization because of its presence in the monomer molecule or the alpha-beta position in relation to the carboxyl group or as part of a terminal methylene grouping. Illustrative of such acids are acrylic, methacrylic, etakrinova, alpha florachilena, crotonic, beta-aryloxypropanolamine, sorbic, alpha-chlorobenzoate, cinnamic, beta-stellacreasy, Mukanova, taconova, Tarakanova, muzakaeva, glucagonoma, akonita, alpha phenylacrylate, 2-benzylacrylamide, 2-cyclohexylaniline, angelic, umbellata, fumaric, maleic acids and anhydrides. Other different olefinic monomers, copolymerisate with such carboxylic monomers include vinyl acetate, vinyl chloride, dimethylmaleic and the like. The copolymers contain sufficient carboxylic groups of salts for solubility in water.

The following class of polymeric means includes a composition containing homopolymers of substituted acrylamide free and/or homopolymers of unsaturated sulfonic acids and their salts, in particular where polymers are based on unsaturated sulfonic acids selected from acrylamidoglycolate sulfonic acids such as 2-acrylamide-2-methylpropane sulfonic acid having a molecular weight from priblisitelno to about 2000000, described in U.S. patent No. 4842847, Jun. 27, 1989, issued by Zahid included in this description by reference.

Another applicable class of polymeric means includes polyaminoamide, especially those containing anionic surface-active amino acids such as aspartic acid, glutamic acid and phosphoserine, as described in U.S. patent No. 4866161 issued by Sikes et al., included in this description by reference.

In obtaining compositions for caring for the oral cavity is sometimes necessary to add some thickening of the substance to achieve the desired consistency, or stabilize, or enhance the presentation of the song. In certain embodiments, the thickeners are carboxyvinyl polymers, carrageenan, hydroxyethyl cellulose and water soluble salts of cellulose ethers such as sodium carboxymethylcellulose and sodium. Natural gums, such as karaya, gum Arabic, and tragacanth gum, can also be included. Colloidal magnesium aluminosilicate or finely divided silica can be used as a component of the thickening composition which further improves the texture of the composition. In certain embodiments, use thickening funds to�the number from about 0.5 to about 5.0 wt.% the total composition.

Compositions for caring for the oral cavity according to the invention may also optionally include one or more enzymes. Applicable enzymes include any of the available proteases, glucanohydrolase, endoglycosidase, amylase, mutans, lipase and Mucins or their compatible mixtures. In certain embodiments, the enzyme is a protease, dextranase, endoglycosidase and Matanza. In another embodiment, the enzyme is papain, endoglycosidase or a mixture of dextranase and atanazy. Additional enzymes suitable for use in the present invention are described in U.S. patent No. 5000939 issued by Dring et al., U.S. patent No. 4992420; U.S. patent No. 4355022; U.S. patent No. 4154815; U.S. patent No. 4058595; U.S. patent No. 3991177 and U.S. patent No. 3696191, all included in this description by reference. The enzyme mixture of several compatible enzymes in the present invention is from about 0.002 percent to about 2% in one embodiment or from about 0.05% to about 1.5% in another embodiment, or in another embodiment, from about 0.1% to about 0.5%.

Water can also be present in compositions for caring for the oral cavity according to the invention. Water used in obtaining commercial composite� to care for the oral cavity, must be deionized and free of organic impurities. Water usually creates a balance of compositions and ranges from approximately 10% to approximately 90%, from about 20% to about 60%, or from about 10% to about 30 wt.% compositions for caring for the oral cavity. This amount of water includes the free water which is added plus that amount which is introduced with other materials such as with sorbitol or any component of the invention.

Within certain embodiments of compositions for caring for the oral cavity is also desirable to include a humectant to prevent curing of the composition when exposed to air. Certain humectants can also impart desirable sweetness or flavor compositions tools for cleaning teeth. The humidifier on the basis of pure moisturizer, usually ranges from approximately 15% to approximately 70% in one embodiment or from about 30% to about 65% in another embodiment by weight of the composition for cleaning teeth.

Suitable humectants include edible polyhydric alcohols such as glycerin, sorbitol, xylitol, propylene glycol, and other polyols and mixtures of these humectants. A mixture of glycerin and sorbitol can be used in defined�'s embodiments as a moisturizing component of the composition of toothpaste in the present description.

In addition to the above components, embodiments of the present invention may contain a variety of optional ingredients for cleaning teeth, some of which are described below. Optional ingredients include, for example, but not limited to, adhesives, foaming tools, flavors, sweeteners, additional funds from plaque, abrasives and dyes. These and other optional components are further described in U.S. patent No. 5004597 issued Majeti; U.S. patent No. 3959458 issued by Agricola et al. and U.S. patent No. 3937807 issued by Haefele, all included in this description by reference.

The compositions of the present invention can be obtained using methods that are conventional in the field of products for the care of the oral cavity.

The present invention in the aspect of his method comprises applying to the oral cavity safe and effective amounts of the compositions described in the present description.

Compositions and methods of the invention are applicable to the way to protect the teeth by facilitating recovery and remineralization, in particular reducing or inhibiting formation of dental caries, reduce or inhibit demineralization and providing remineralization of the teeth, reduce hypersensitivity of the teeth, and reduce, restore�effect or inhibition precariously lesions of the enamel, for example, determined by quantitative light-induced fluorescence (QLF) or electrical rating of caries (ECM). Quantitative light-induced fluorescence is a system of visible light, which allows early identification precariously lesions of enamel. Normal teeth fluoresce in visible light; with demineralized teeth this not happening or only to a lesser degree. Area of demineralization can be quantified and tracked the progression. The conductivity measurement uses the fact that the tube filled with liquid is subjected to demineralization and erosion of the enamel conduct electricity. The increase in conductivity of the patient's teeth, therefore, may indicate demineralization. Consequently the composition of the invention are applicable in the method of reducing precariously lesions of the enamel (which was measured with QLF or ECM) relative to compositions that do not have effective amounts of fluorine and/or arginine.

The composition of the invention are further applicable in ways to reduce the amount of harmful bacteria in the oral cavity, for example, in methods of reducing or inhibiting gingivitis, reduce levels of bacteria that produce acid, increasing the relative level of alginolyticus bacteria, inhibiting the formation �mikrobnoi biofilms in the oral cavity, improve and/or maintain the pH level at least approximately pH 5.5, reduce the accumulation of plaque and/or cleaning of teeth and oral cavity.

Finally, by increasing the pH in the mouth and counteracting pathogenic bacteria, the composition of the invention are applicable to ensure the healing of wounds or cuts in the mouth.

Compositions and methods of the invention can be included in compositions for oral care and teeth such as toothpastes, transparent pastes, gels, rinses mouth, sprays and chewing gum.

The level of active ingredients will vary based on the nature of the delivery system and a specific active substance. For example, the basic amino acid may be present at levels from, e.g., about 0.1 to about 20 wt.% (expressed as weight of free base), for example, from about 0.1 to about 3 wt.% to rinse the mouth, from approximately 1 to approximately 10 wt.% for toothpaste for the consumer or from about 7 to about 20 wt.% for a professional product or product prescribed for the treatment. Fluoride may be present at the level of, for example, from about 25 to about 25,000 ppm, for example, from about 25 to about 250 ppm d�I rinse for the mouth, from about 750 to about 2000 ppm for a consumer toothpaste or from about 2,000 to about 25,000 ppm for professional product or product prescribed for the treatment. The level of antibacterial agents will vary in a similar way, with the levels used in toothpaste, for example, from about 5 to about 15 times greater than used in the rinse for the mouth. For example, rinse the mouth with triclosan may contain, for example, about 0.03 wt.% triclosan, whereas toothpaste with triclosan may contain about 0.3 wt.% triclosan.

The improvement of the health of the oral cavity also provides advantages in General health, because the tissue of the oral cavity may be the gateway for systemic infections. Good health of the oral cavity associated with the General state of health, including the cardiovascular system. Compositions and methods of the invention provide certain advantages, because the essential amino acids, especially arginine, are sources of nitrogen that supports the path of NO synthesis and thus increases microcirculation in the tissues of the oral cavity. Providing a less acidic environment of the mouth is also beneficial in reducing zheludochno�th distress and creates an environment less acceptable for Heliobacter, which is associated with stomach ulcers. Arginine, in particular, is required for high expression of specific receptors of immune cells, for example, receptors of T cells, so that arginine can enhance an effective immune response. Compositions and methods according to the invention are therefore applicable to enhance systemic health, including the cardiovascular system.

As used throughout the description of the ranges as boundaries to describe each and every one of the values that are within range. Any value in the range can be selected as the end of the range. In addition, all references cited in the present description, are thus included in this description by reference in full. In the event of a conflict in the definition in the present description and such of the aforementioned references, the present description dominates. Understand that when compositions are described, they can be described in terms of their ingredients, as usual in engineering, although these ingredients can react with each other in specific compositions in the preparation, storage and use, and such products are intended for embracing the described compositions.

The following examples further describe and demonstrate illustrative options for implementation�ia of the invention within the present invention. Examples are given solely for illustration and should not be construed as limitations of the present description, as many variants are possible without deviation from its trend. Various modifications of the invention in addition to the shown and described herein are obvious to the expert in the field of engineering and is intended for embracing the attached claims.

Example 1

Received a premix consisting of 4.26 g of heavy water (D2O), 0.40 g of L-arginine and 0.24 g of sodium bicarbonate, having an initial pH of 9.74. The premix was adjusted to pH 8,99 with 34% HCl solution. Proton NMR was used to record the spectrum and showed the complex of arginine bicarbonate.

Example 2

Received a premix consisting of 4.26 g (D2O, 0.40 g of L-arginine and 0.31 g of sodium bicarbonate, having an initial pH 11,74. The premix was adjusted to pH 9,01 with 34% HCl solution. Proton NMR was used to record the spectrum and showed the complex of arginine bicarbonate.

1. Composition for caring for the oral cavity comprising a premix containing arginine in free form or in salt form, a soluble carbonate salt and bicarbonate of arginine formed in situ by mixing arginine in free form or in salt form with a soluble carbonate salt.

2. Composition for caring for the oral cavity according to claim 1 having a pH of from about 8.5 to rough�about a 9.5.

3. Composition for caring for the oral cavity according to claim 1, wherein the basic amino acid is present in an amount of from about 1 wt.% to about 10 wt.% the total weight of the composition.

4. Composition for caring for the oral cavity according to claim 1, wherein the soluble carbonate salt is selected from sodium carbonate, sodium bicarbonate and mixtures thereof.

5. Composition for caring for the oral cavity according to claim 1, further comprising an effective amount of a source of fluoride.

6. Composition for caring for the oral cavity according to claim 1, further comprising an abrasive material, where the abrasive is selected from precipitated calcium carbonate, silicon dioxide and mixtures thereof, or further comprising at least one surface-active agent, or further comprising at least one moisturizer, or further comprising an antibacterial agent, or further comprising a physiologically acceptable potassium salt in amounts effective to reduce the sensitivity of teeth.

7. Composition for caring for the oral cavity according to claim 1, wherein the composition is a toothpaste.

8. Composition for caring for the oral cavity according to claim 1, where the composition is a rinse for the mouth.

9. A method of obtaining a composition according to claim 1, comprising: obtaining a premix by mixing arginine in free form or in salt form, and a soluble carbonate with�.

10. A method according to claim 9, wherein the mixture contains from about 7 to about 10 wt.% basic amino acids, weight is given in the form of the free base.

11. A method according to claim 9, where the carbonate salt is selected from sodium carbonate, sodium bicarbonate and mixtures thereof.

12. A method according to claim 9, where the molar ratio of arginine to bicarbonate ion is from about 4:1 to about 1:4.

13. A method according to claim 9, where the composition is brought to a pH of approximately 9.

14. A method according to claim 9, where the composition is to care for the oral cavity contains more materials selected from the group consisting of fluoride, abrasives, surfactants, moisturizers, antibacterial agents, calcium salts, potassium salts, and combinations thereof.

15. The way to care for the oral cavity comprising introducing an effective amount of a composition according to claim 1 into the oral cavity of a patient in need of the (i) reduce or inhibit formation of dental caries, (ii) reduce, repair or inhibit precariously lesions of the enamel, (iii) reduce or inhibit demineralization and remineralization of the teeth, (iv) reduce hypersensitivity of the teeth, (v) reduce or inhibit gingivitis, (vi) to promote the healing of wounds or cuts in the mouth, (vii) reducing the level of bacteria that produce acid, (viii) the relative increase of UB�nya alginolyticus bacteria (ix) the inhibition of the formation of microbial biofilms in the oral cavity, (x) raise and/or maintain the pH of plaque at the level of at least pH 5.5 after exercise sugar, (xi) reduce plaque accumulation, and/or (xii) clean the teeth and oral cavity.



 

Same patents:

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to the field of pharmaceutics and represents a composition for oral cavity care in the form of dental varnish, containing bioactive glass and fluoride, where the said fluoride is present in the composition in an amount of up to 5% by weight. An increased ionic release is observed for the dental varnish containing bioactive glass and fluoride.

EFFECT: invention provides the creation of compositions, containing bioactive glass, for which in case of applying fluoride in lower concentrations (lower than 900 mln-1) its efficiency is the same as for higher concentrations (900 - 1450 mln-1).

3 cl, 2 ex, 6 tbl

FIELD: chemistry.

SUBSTANCE: invention relates to a compound with a woody note having structural formula I. In formula , the ring with 6 carbon atoms is saturated or has a double bond between carbon atoms C1 and C2 or between carbon atoms C1 and C6, R is selected from a C2-C5 alkyl or C2-C5 alkenyl group.

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13 cl, 16 ex

FIELD: chemistry.

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18 cl, 7 ex, 10 tbl

FIELD: medicine.

SUBSTANCE: method involves: a) preparing a polymer matrix film containing a water-soluble polymer and a hydrophobic/lipophilic additive and being substantially free from a poorly-soluble flavour; b) preparing a dental care base containing the poorly-soluble flavour; c) combining the polymer matrix film with the prepared base; and d) keeping the combined polymer matrix film and base for the period of time adequate to transfer an effective amount of the above flavour from the base of the dental care agent into the above polymer matrix film. That involves using the flavour specified in a certain list of poorly-soluble flavours (menthol, thyme oil, etc.), and one or more hydrophobic/lipophilic additives specified in a group of specific additives (Vaseline, silicone oil, etc.). The agent prepared by the above method has the same characteristics as the agents prepared by a common method, when the prepared films containing the flavour are added to the base of the dental care agent.

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14 cl, 9 tbl, 2 ex

FIELD: cosmetology.

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2 ex

FIELD: medicine.

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3 cl

Elastase inhibitor // 2548794

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6 cl, 2 dwg, 6 ex

FIELD: cosmetology.

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5 tbl

FIELD: chemistry.

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3 cl, 2 tbl, 8 ex

FIELD: medicine, pharmaceutics.

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17 cl, 2 tbl, 15 ex

FIELD: chemistry.

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2 ex

FIELD: medicine, pharmaceutics.

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11 cl, 7 ex

FIELD: chemistry.

SUBSTANCE: method for photodynamic inactivation and inhibition of growth of Enterococcus faecalis bacteria, based on pretreatment of the bacteria with a hypericin-containing photosensitiser based on an alcoholic tincture of hypericum "Diahyperon" or "Hypericum tincture" and subsequent exposure of the obtained suspension to optical radiation of laser or LED sources with transmission maxima in the region corresponding to absorption spectrum maxima or maxima of the excitation spectrum of fluorescent components of the preparations with radiation energy density of 0.9-9.0 J/cm2, under certain conditions.

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22 cl, 7 dwg, 3 tbl

FIELD: medicine.

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3 tbl

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to the field of pharmaceutics and represents a composition for oral cavity care in the form of dental varnish, containing bioactive glass and fluoride, where the said fluoride is present in the composition in an amount of up to 5% by weight. An increased ionic release is observed for the dental varnish containing bioactive glass and fluoride.

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3 cl, 2 ex, 6 tbl

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to pharmaceutical industry, in particular to application of composition for preparation of medications aimed at secondary prevention of cardiac infarction. Application of composition based on substances, applied in Chinese medicine, for preparation of medications aimed at secondary prevention of cardiac infarction, with composition, based on substances, applied in Chinese medicine, is prepared from composition, which contains Radix Astragali, Radix Salviae Miltiorrhizae, Radix Notoginseng and Lignum Dalbergiae Odoriferae, taken in specified ratio.

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14 cl, 8 dwg, 74 tbl, 10 ex

FIELD: chemistry.

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13 cl, 16 ex

FIELD: medicine.

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EFFECT: method provides correction of biological age of organism as prevention of premature ageing.

3 cl, 4 tbl, 2 ex

FIELD: chemistry.

SUBSTANCE: invention relates to a compound of formula (I) : or a salt thereof, wherein R1 and R5 are independently selected from H, OH and alkoxy; R2-R4 and R6-R8 are independently selected from H, OH, F, Cl, Br and I; R9 and R10 are C2-C8 alkenyl; under the condition that at least one of R1, R5 and R7 is OH or alkoxy; at least one of R2-R4, R6 and R8 is F, Cl, Br or I; and R2 and R6 are Cl. The invention also relates to an antibacterial composition and treatment methods.

EFFECT: improved properties.

18 cl, 7 ex, 10 tbl

FIELD: veterinary medicine.

SUBSTANCE: product comprises Lycopodium clavatum, Acidum arsenicosum, Phosphorus, Podophyllum peltatum, Thuja occidentalis, Echinacea purpurea, Silybum marianum, Selenocysteine, and the components are taken in the dilutions described below in the following ratio, in parts: Lycopodium clavatum ⌀=D1 0.004, Podophyllum peltatum ⌀ 0.003, Acidum arsenicosum ⌀=D2 0.0001, Phosphorus ⌀=D3 0.001, Thuja occidentalis ⌀ 30, Echinacea purpurea ⌀ 30, Silybum marianum ⌀ 60, Selenocysteine 0.2.

EFFECT: product has an effective stress-protective and growth-stimulating effect, it regulates the metabolism in young farm animals.

3 cl, 10 tbl, 1 ex

FIELD: medicine, oncology, amino acids.

SUBSTANCE: invention relates, in particular, to the development of an antitumor preparation based on natural substances. Invention relates to an amino acid preparation comprising at least one modified essential amino acid obtained by treatment of amino acid by ultraviolet radiation (UV) at wavelength 250-350 nm for 12-80 h at temperature 15-30oC or with ozone at temperature 15-25oC. The modified amino acid has no toxicity for health cells. Also, invention relates to a method for preparing such preparation. Invention provides the development of an antitumor preparation based on modified amino acids and expanded assortment of antitumor preparations being without cytotoxicity for normal cells.

EFFECT: valuable medicinal antitumor properties of preparation.

8 cl, 4 tbl, 2 dwg, 4 ex

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