Method for producing befungin preparation of chaga muschroom

FIELD: medicine.

SUBSTANCE: method for producing Befungin, a preparation of Chaga mushroom involving extracting the milled raw material in heated water on a heating unit consisting of 3 reactors; adding cobalt salts to the extract in certain environment, mixing with ethanol, evaporating to dry residue of 20-25%.

EFFECT: method enables accelerating the production process, reducing energy demands, improving the quality and completeness of extraction, and improving the quality of the preparation.

2 dwg, 1 tbl, 1 ex

 

The invention relates to the production of medicines and can be used to obtain the medicines Befangen birch fungus chaga formed on the birches pathogenic parasite In Canada. The drug has a tonic, tonic, antioxidant, immunomodulatory, anti-inflammatory effect. It normalizes the metabolism and activity of the gastrointestinal tract, is symptomatic improve the General condition of cancer patients. Used in diseases of the gastrointestinal tract (hypoacid gastritis, peptic ulcer disease, polyposis of the stomach and intestines, hypokinesia of the biliary tract and intestine), and skin diseases, periodontal disease and as symptomatic agents in cancer.

The known method, comprising: obtaining a raw juice fungus, its treatment with an aqueous solution hyperazotemia polymer with a concentration of 1·10-7-1·10-20% in the ratio of 10:1 at room temperature for 0.5-1.5 h, the deposition of polyphenolic complex of a 20% solution of hydrochloric acid to a pH of 2.0-2.2 with obtaining sediment polyphenolic complex, and as hyperazotemia polymer used Boltorn 40 [RU 2425686, C1, A61K 36/06, 10.08.2011].

The disadvantage of this method is the relatively high complexity�the awn.

In addition, a method of producing a precipitated drug from birch fungus chaga by obtaining diffusion juice of fungus, of his deposition, adding 20% hydrochloric acid to pH of 2.0-2.2, to the stage of deposition by diffusion juice chagi add a water solution of hyperazotemia polymer with a concentration of 1·10-7-10-20% in the ratio of 10:1, the treatment is carried out at room temperature for 0.5-1.5 h [RU 2366439, C1, A61K 36/06, 10.09.2009].

The disadvantage of this method is the relatively high complexity.

There is also known a method of obtaining powder of fungus, including grinding of raw materials in an inert liquefied gas, swiezegowno raw material pre-treated with an inert liquefied gas for 30-60 min, then dried by vacuum sublimation to a residual moisture content of 1-8%, and the ratio of raw materials and liquefied inert gas during a pretreatment svezhezavarennogo raw materials and grinding in inert liquefied gas take(1:1)-(1:3) [EN 2167665, C1, A61K 35/78, 27.05.2001].

This method is also characterized by relatively high complexity.

Closest to the proposed prototype is a method for producing of preparation from birch fungus chaga, including heated water extraction of crushed middlings chagi (up to 2-3 mm), the Addendum to the extract �Olya cobalt, boiling down to 32-33% of total solids, mixing with alcohol-rectified to obtain the thick extract and further drying of the resulting mixture [SU 104607, A1, A61K 35/78, 01.01.1956].

The disadvantage of this method is the relatively low quality of the product because it has not provided the modes of carrying out the individual stages of the method provides increased extraction.

Grinding chagi to the size of 2-3 mm at the extraction depletes a large amount of ballast substances in the extractant and the difficulty in filtering.

The boiling of the extract up to 32-33% of total solids has its drawbacks:

the extension of the duration of production, the increase in energy costs;

- shortness of discharge from the reactor, as well as loss - settling on the walls of the reactor;

- increase the duration of the standardization process;

is the difficulty in packing the product;

- inconvenience of use for the consumer, since a thick mass of hard to dose.

The required technical result is a significant acceleration of the process of production; the reduction of energy consumption per unit of production; improving the quality of extraction; and the achievement of completeness of extraction; increase production; improve the quality of the drug.

The required technical result is achieved in that in the method of receiving�Oia drug Befangen birch fungus chaga including heated water extraction of crushed raw material, adding to the extract of cobalt salts, evaporation and mixing with ethyl alcohol, grinding of raw materials to produce particles with sizes from 7 to 15 mm, the extraction of active substances from birch fungus chaga is carried out on the battery of the 3 reactors by mixing powdered raw materials with the extractant in a weight ratio of 1:10 and soak for 1.5 hours in the reactor at a temperature of 68-72°C, then the extract is drained into the collection, add to the extraction of cobalt salts with subsequent evaporation of the extract at a temperature of 70-80°C under a vacuum of 0.06 MPa to dry residue 20-25%.

In addition, the required technical result is achieved in that in each reactor battery serves extractant 3 times, then make the replacement of depleted raw materials - fungus on fresh.

In addition, the required technical result is achieved in that the last two extraction before draining the finished drawing on fresh produce raw materials, and then the extract is drained into the collection.

The scheme of extraction (see Fig. 1 and Fig. 2) and evaporation of the extract at a temperature of 70-80°C under a vacuum of 0.06 MPa can significantly speed up the manufacturing process of the drug Befangen (up to 20% of the time for 1 batch of finished product).

Mpariwa�their hoods to dry residue 20-25% to reduce the energy consumption for the production of up to 10% and to reduce losses during unloading of the extract from the reactor, to facilitate the filling and dosing of the drug.

Grinding chagi to the optimum particle size of from 7 to 15 mm (chosen experimentally) is used to improve the extraction process and reduce the leaching of ballast substances, which increases the quality of the products.

The optimal ratio of 1:10 raw chaga and extractant allows maximum use of raw materials.

The optimum temperature range of 68-72°C in the extraction process allows to achieve a better extraction of the active substance (polyphenol complex) of chaga to 30%.

An example implementation of the proposed method, which is used in the preparation of the drug Befangen.

Produce grinding birch fungus chaga to a particle size of from 7 to 15 mm.

Extraction hoods birch fungus chaga is carried out by mixing ground chaga mushroom with purified water.

Extraction of active substances from birch fungus chaga is carried out on the battery of the 3 reactors at a temperature of from 68 to 72°C, and heating is carried out by contact with live steam or in a contactless manner to the deaf ferry with a shirt.

In the reactor P. 1 comminuted chaga mushroom and pour the purified water. Insist birch fungus chaga in P. 1 reactor for 1.5 hours at a temperature of from 68 to 72°C. In the reactor P. 2 comminuted chaga mushroom and make �eredivise extracts from P. 1 reactor. In the reactor P. 1 again poured water. Heated the contents of the reactor from 68 to 72°C. after 1.5 hours the first batch of finished extract is drained from the reactor P. 2 in the collection.

The extract of P. 1 reactor is moved into the reactor P. 2. In the reactor P. 1 again poured water.

Carry out the extraction in reactors P. 1 and P. 2 at a temperature of from 68 to 72°C for 1.5 hours. In the reactor P. 3 comminuted chaga mushroom and make the relocation extracts from P. 2 reactor. After and before movement and before discharge to the reactors produce circulation (mixing). Meal from P. 1 reactor was removed, the reactor was washed and re-load the chopped mushroom the chaga. Make relocation of extracts from the reactor P. 3 P. 1 reactor, from the reactor P. 2 P. 3 reactor. Carry out the extraction in reactors P. 1 and P. 3 at a temperature of from 68 to 72°C. After 1.5 hours, the second batch of the finished extract is discharged into the collection from P. 1 reactor. In each reactor battery serves extractant 3 times. In the P. 1 reactor at the beginning of the operating cycle pour water 3 times. The last two extraction before draining the finished drawing is carried out on fresh material, and then the extract is drained into the collection (see Fig. 1 and Fig. 2).

The next stage is adding to the extraction of cobalt salts is based on the density of the hood. Take a sample drawing, determine the density and find the necessary amount of cobalt salts.

Approx�p

At 20°C and a density of the exhaust 1,038 g/cm3the required amount of cobalt chloride will be 0.84 g on 1 l of the drawing, and cobalt sulfate - 0,996 g / 1 l

Cobalt salts dissolved in a small amount of an extract in an intermediate container and then pour the resulting solution into the collection.

Then spend stage evaporation to obtain a liquid extract with a solids content of 20-25%. The evaporation was conducted under vacuum of 0.06 MPa when operating the stirrer and the temperature from 70 to 80°C. the Liquid extract is discharged from the reactor in the intermediate tank.

After the analysis of the liquid extract is the Addendum in the extract of ethyl alcohol and, if necessary, purified water to obtain a product with a solids content of 15-20%. The amount of ethyl alcohol and purified water is determined by the necessary calculations, based on the analysis results.

Example of calculation

Have a sample of the extract weight 380 kg and with a mass fraction of solids 22%. It is necessary to calculate the amount of purified water and ethyl alcohol required to obtain the mass fraction of solids of 19.8%.

1. Determine the mass of Befangen after mixing:

2. Determine the mass of ethyl alcohol to 96.3% (about.d.).

Accept that the final concentration of ethyl alcohol in Befangen will be 11% (about.d.):

where

M2- the mass of Befangen after standardization;

It is the content of ethyl alcohol in litres per 1 kg of solution, depending on the concentration used alcohol on the table for the determination of ethyl alcohol in water-alcohol solutions (see table 1):

where

0,112 - the amount of alcohol in litres per 1 kg of the 11% solution,

1,1961 - the amount of alcohol in litres per 1 kg to 96.3% solution.

3. Determine the mass of purified water:

422,22-380-39,54=2,68 kg

According to the calculation of a liquid extract mixed with ethyl alcohol and purified water.

After receiving positive results of this analysis, Befunge is drained from the reactor by gravity into an intermediate container with filtration through the filter-fungal. On the bottle with filtered by Beforeno gets a label stating the name of the drug, batch numbers, mass and moved to the packaging area.

A method of producing the drug Befangen birch fungus chaga, including heated water extraction of crushed raw material, adding to the extract of cobalt salts and mixing with ethyl alcohol, characterized in that the grinding of raw materials to produce particles with sizes from 7 to 15 mm, the extraction of active substances from birch fungus chaga is carried out on the battery of the 3 reactors PU�eat a mix of crushed raw material with the extractant in a weight ratio of 1:10 and soak for 1.5 hours in the reactor at a temperature of 68-72°C, moreover, in each reactor battery serves extractant 3 times and the last two extraction before draining the finished drawing to happen on fresh raw materials, then the extract is drained into the collection; add to the extraction of cobalt salts and produce evaporation at a temperature of 70-80°C under a vacuum of 0.06 MPa to dry residue 20-25%.



 

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