Cosmetic preparation for skin in form of "water-in-oil" type emulsion

FIELD: chemistry.

SUBSTANCE: invention represents a cosmetic preparation for skin in the form of a "water-in-oil" type emulsion, which contains water, ethanol, volatile oily component, carboxydecyltrisiloxane of formula (1): 0.1-5 wt % and one, two or more components, selected from the group, consisting of hydrophibised titanium dioxide, hydrophibised zinc dioxide and hydrophibised iron dioxide.

EFFECT: removal of powder squeakiness on the skin in the course of time after application and simultaneous improvement of absorption into the skin during application and absence of stickiness after application on the skin.

3 cl, 2 tbl, 8 ex

 

Area of technology

The present invention relates to a cosmetic treatment for the skin in the form of an emulsion type water in oil". More specifically it relates to a cosmetic treatment for the skin in the form of an emulsion type water in oil", which added one, two or more powders selected from the group consisting of gidrofobizirovannogo titanium dioxide, gidrofobizirovannogo zinc oxide and gidrofobizirovannogo iron oxide, which eliminated scriptsisti powder on the skin over time after application, improved absorption into the skin during application and improved the absence of stickiness after application to the skin.

Prior art

In the patent document 1 discloses a cosmetic, which is a pigment dispersion containing a pigment consisting of titanium dioxide and/or zinc oxide, and the solvent dispersion consisting of a liquid oil and a dispersing agent, a dispersing agent using a special reactive organically modified silicone. As a result it is a cosmetic that exhibits effects such as good raspadaemosti, improved the transparency of the coating film, the lack of poroshkoobraznoe and no unnatural whiteness.

Reactive forces organically modified�con, used in patent document 1, contains the amino-modified silicone and/or carboxy-modified silicone, in particular, reactive organically modified silicone, which has a higher molecular weight than the molecular weight of carboximetilcelulosa used in the invention of the present application. Therefore, the composition of the specified cosmetic products has a high viscosity and when applied on the skin it is impossible to obtain a uniform covering film.

In addition, when liquid oil evaporates over time, the pigment covering film this cosmetics loses fluidity so the issue of scriptsisti powder can not be effectively resolved.

On the other hand, in patent document 2 reports on the invention, which uses carboximetilcelulosa, which is a carboxy-modified silicone used in the invention of the present application.

However, the invention of patent document 2 relates to a method for producing powdery cosmetic products from the dried powder, which includes the process of obtaining slurry for mixing a powder component with a non-volatile oily component as a binder and carboxymethyl-modified silicone as a dispersant in a volatile Sol�evaporator to obtain a suspension, and the process of drying to obtain a dry powder, where the drying process used dryer, which produces small droplets of the suspension as a result of mechanical shearing force and for drying of a suspension on these small droplets is supplied drying gas", and this invention provides a method for producing powdery cosmetic which is excellent in respect of the length of the coating; this invention is perfect intrinsically different in comparison with the invention of the present application.

The prior art documents

Patent documents

Patent document 1: JP 2002-80771 And Patent document 2: JP 2010-143844 And

Disclosure of the invention

The technical problem

The authors present invention found that by selecting carboximetilcelulosa having a special structure of the carboxy-modified silicones and add the specific number of carboximetilcelulosa, special water, special amount of ethanol and a particular quantity of volatile oil component in cosmetic for the skin, in the form of an emulsion type water in oil" containing powder, such as titanium dioxide, zinc oxide and iron oxide, which are often used in cosmetic products, you can fix scriptsisti powder on the skin over time after application and can�ussite absorption into the skin during application and the absence of stickiness after application to the skin, and thus, completed the present invention.

The object of the present invention is to offer beauty products for the skin, in the form of an emulsion type water in oil", which added one, two or more powders selected from the group consisting of titanium dioxide, zinc oxide and iron oxide, which eliminated scriptsisti powder on the skin (tactile sensation to the lack of smoothness) over time after application, improved absorption into the skin during application and improved the absence of stickiness after application to the skin.

Technical solution

Thus, the present invention provides a cosmetic for the skin, in the form of an emulsion type water in oil" containing the following ingredients (a) to(e):

(a) water: 5-50 wt.%

(b) ethanol: 1-20 wt.%

(c) component of volatile oil: 2-50 wt.%

(d) carboximetilcelulosa of formula (1): 0.1-5 wt.%

(e) one, two or more selected from the group consisting of gidrofobizirovannogo titanium dioxide, gidrofobizirovannogo zinc oxide and gidrofobizirovannogo iron oxide: 2-50 mass%.

In addition, the present invention provides the above-described cosmetic for the skin, in the form of an emulsion type water in oil", which uses a polyester-modified silicone (f) emulsification of this cosmetic supplier got government Fund�ski for the skin in the form of an emulsion type water in oil".

In addition, the present invention provides the above-described cosmetic for the skin, in the form of an emulsion type water in oil", which further comprises an absorber (d) ultraviolet radiation.

The beneficial effects of the invention

According to the present invention it is possible to obtain a cosmetic for the skin, in the form of an emulsion type water in oil" and adds the powder normally used in cosmetics, such as gidrofobizirovannym titanium dioxide, zinc oxide and iron oxide, which eliminated scriptsisti powder on the skin over time after application and squeaky feeling is absent.

In addition, according to the present invention, it is possible to obtain a cosmetic for the skin, in the form of an emulsion type water in oil" and adds the powder normally used in cosmetics, such as gidrofobizirovannym titanium dioxide, zinc oxide and iron oxide, which improved absorption into the skin during application and improved the absence of stickiness after application to the skin.

Best mode for carrying out the invention

The present invention is described in detail below.

"(and) Water"

The choice of water used is not specifically limited, it is preferable to use water purified by ion exchange.

In the present invention, the water together with Dr.�ugih ingredients water based is the aqueous phase, that is the inner phase skin cosmetic emulsion of the type "water in oil".

The water content is 5-50 wt.%, preferably 6-40 wt.%, of the total number of skin cosmetic emulsion of the type "water in oil".

"(b) Ethanol"

In the present invention, the ethanol along with water is the aqueous phase, which is the internal phase skin cosmetic emulsion of the type "water in oil".

The ethanol content is 1-20 mass%, preferably 3-15 mass%, of the total number of skin cosmetic emulsion of the type "water in oil".

"(C) the volatile oil component"

Examples of volatile oil component used in the present invention include relatively low molecular weight hydrocarbon oils of relatively low molecular weight silicones with a straight chain and a relatively low molecular weight cyclic silicones; especially preferred are light liquid isoparaffin, isododecane, isohexadecane, volatile dimethylpolysiloxane and cyclic polysiloxane. Particularly preferred are octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, Dodecamethylcyclohexasiloxane and hexadecyltrichlorosilane. Especially preferred are liquid isoparaffin, isododecane from�hexadecan and decamethylcyclopentasiloxane.

Volatile oil component used in the present invention is the ingredient that together with oil components in other possible ingredients form an oil phase, i.e., the outer phase skin cosmetic emulsion of the type "water in oil". And fine powder gidrofobizirovannogo zinc oxide, titanium dioxide and oxide of iron, i.e. component (d), uniformly dispersed in the oil component of the outer phase.

The content of volatile oil component is 2-50 wt.%, preferably 5-45 wt.%, more preferably 10-40 wt.%, of the total number of skin cosmetic emulsion of the type "water in oil".

Selection of the oil component in the possible ingredients in the oil phase is not specifically limited; examples include fats and oils, waxes, hydrocarbon oils, vegetable oils, higher fatty acids, higher alcohols, synthetic esters and silicone oils. The content is determined by what is suitable for the product; can usually be added 3-20 wt.% of the total number of skin cosmetic emulsion of the type "water in oil".

"(d) Carboximetilcelulosa of formula (1)"

Carboxy-modified silicone used in the present invention, is carboximetilcelulosa formulas� (1).

This ingredient (d) in the present invention is an essential ingredient that is dissolved in the oil phase of cosmetic products for skin in the form of an emulsion type water in oil", this ingredient eliminates scriptsisti a fine powder of zinc oxide, titanium dioxide and iron oxide.

Chemical formula 1

The chemical name of this compound is 3-(10-carboxymethyl)-1,1,1,3,5,5,5-heptamethylnonane; this is a carboxy-modified silicone according to the prior art. In the present invention preferably use commercial products such as Dow Corning Toray OP-1800MF Carbohy Fluid (from Dow Corning Toray)".

Carboximetilcelulosa of formula (1) is, as stated above, the carboxy-modified silicone according to the prior art, which is an ingredient in cosmetics. However, it is never mixed with cosmetic remedy for skin emulsion of the type "water in oil" containing one, two or more powders selected from the group consisting of titanium dioxide, zinc oxide and iron oxide, as an ingredient in cosmetic products, which eliminates scriptsisti powder on the skin on the skin over time after application. And the effect of the present invention, i.e., the removal of scriptsisti powder on the skin over time �after application and simultaneously improve absorption into the skin during application and the absence of stickiness after application to the skin thanks to the introduction of the compositions of the present invention, is unpredictable a significant effect found for the first time by its author.

The content of carboximetilcelulosa of formula (1) is 0.1-5 wt.%, preferably 0.1 to 3 mass%, more preferably 0.5 to 2 mass%, of the total number of skin cosmetic emulsion of the type "water in oil".

"(e) One, two or more selected from the group consisting of gidrofobizirovannogo titanium dioxide, gidrofobizirovannogo zinc oxide and gidrofobizirovannogo iron oxide"

Titanium dioxide and zinc oxide powders are often used in sunscreen cosmetics, for example, as absorbers of ultraviolet radiation; these powders have a tendency to cause scriptsisti powder after applying cosmetics.

In addition, the iron oxide powder is often used to improve the brightness of the skin after application or to improve the brightness of the skin and smoothing skin color after application; it is also a powder that tends to cause scriptsisti powder after applying cosmetics.

These powders is gidrofobizirovannym powders; selection gidrofobiziruyuschih agent and/or method of gidrofobizirovan unlimited, and water-repellent treatment is carried out using known in the �Ethniki gidrofobiziruyuschih agent in the usual way. Examples gidrofobiziruyuschih agent include silicone agents, fatty acids, Soaps of fatty acids and esters of fatty acids. Examples of silicone agents include silicone oils, such as metallographically, dimethylpolysiloxane and methylphenylpolysiloxane, various alkylsilane, such as methyltrimethoxysilane, ethyltrimethoxysilane, hexyltrimethoxysilane and octyltrimethoxysilane and various coralcalcium, such as triftormetilfullerenov and . Examples of fatty acids include palmitic acid, isostearoyl acid, stearic acid, lauric acid, myristic acid, behenic acid, oleic acid, resin acid and 12-hydroxystearic acid. Examples of fatty acid Soaps include aluminum stearate, calcium stearate and 12-hydroxystearic aluminum. Examples of the ether fatty acids include dextrin esters of fatty acids, cholesterol esters of fatty acids, sucrose esters of fatty acids and starch esters of fatty acids. One, two or more of these waterproofing agents can be used for water-repellent treatment of a fine powder in accordance with a customary method.

Gidrofobizirovannym fine powder is uniformly dispersed in the oil phase, i.e. in the outer phase.�funds to CSOs for the skin in the form of an emulsion type water in oil" of the present invention.

In the case of the powder from the point of view of protection against ultraviolet radiation, improve the color or brightness unevenness of the skin after application, it is preferred to use a fine powder having an average particle size of 10-1000 nm. The average particle size is measured in the usual way, such as, for example, the definition of average diameter by the method of image analysis with the electron microscope.

The content of one, two or more powders selected from the group consisting of titanium dioxide, zinc oxide and iron oxide, is 2-50 wt.%, preferably 5-40 wt.%, more preferably 7-35 wt.% of the total number of skin cosmetic emulsion of the type "water in oil".

"(f) a Polyester-modified silicone"

As a surfactant (emulsifying agent), used in cosmetics for skin emulsion of the type "water in oil" of the present invention, preferred is a polyester-modified silicone.

The choice of a polyester-modified silicone used in the present invention is not specifically limited; examples include compounds containing a branched silicone chain and/or the alkyl chain. Examples of commercially available polyether-modified silicones include Silicone KF-6017P, Silicone KF-6028 and Silicone KF-6038 from the company Shin-Etsu hemical Co., Ltd., and Abil stock EM 90 from the company Degussa GmbH.

In the present invention can also be used surfactants (emulsifying agents) different from the polyester-modified silicones, inasmuch as there is no negative impact on the effect of the present invention.

The content of the polyester-modified silicone is 0.1-10 wt.%, preferably 0.5 to 5 mass%, of the total number of cosmetic products.

"(g) UV absorbers"

In cosmetic for the skin, in the form of an emulsion type water in oil" of the present invention is also preferable to add UV absorbers to use it as a sunscreen. In particular, if you add the zinc oxide and/or titanium dioxide, which are agents that scatter ultraviolet radiation, provides the advantage of enhancing the protective effect of ultraviolet radiation in addition to the absorption of the ultraviolet radiation.

Examples of the ultraviolet absorbers of radiation include the following compounds.

(1) the Absorbers of ultraviolet radiation on the basis of for Example benzoic acid, para-aminobenzoic acid (hereinafter abbreviated as RAV),

monoglyceride ether RAV, ethyl ether of N-dipropoxy-RAV, N,N-diethoxy-RAV ethyl ether N. N-dimethyl-RAV, butyl ether N. N-dimethyl-RAV and ethyl ether N. N-dimethyl-RAV.

(2) Absorbers of ultraviolet radiation on the basis of Anthranilic acid, for example, gommendy-S-acetylanthranilic.

(3) the Absorbers of ultraviolet radiation on the basis of salicylic acid, for example, abililities, methylsalicylate, homogentisate, octisalate, salicylate, benzalkonium and p-

isopropylbenzylamine.

(4) the Absorbers of ultraviolet radiation on the basis of cinnamic acid, for example, octilinear, ethyl-4-isopropylmalate, methyl-2,5-Diisopropylamine, ethyl-2,4-diisopropylamino, methyl-2,4-diisopropylzinc, propyl-p-methoxycinnamate, isopropyl-p-methoxycinnamate, isoamyl-p-methoxycinnamate, octyl-p-methoxycinnamate (2-ethylhexyl-p-methoxycinnamate), 2-ethoxyethyl-p-methoxycinnamate, cyclohexyl-p-methoxycinnamate, ethyl-a-cyano-p-phenylcinnamic, 2-ethylhexyl-a-cyano-p-phenylcinnamic and glycerion-2-).

(5) the Absorbers of ultraviolet radiation on the basis of triazine Examples include bestesonlinecasino.

More specifically, bis{[4-(2-ethylhexyloxy)-2-hydroxy]phenyl}-6-(4-methoxyphenyl)-1,3,5-triazine and 2,4,6-Tris{4-(2-ethylhexyloxymethyl)-Anil Ino}-1,3,5-triazine.

(6) Other absorbers of ultraviolet radiation, for example, 3-(4'-methylbenzylidene)-C1,1-camphor�, 3 benzyliden-C1,1-camphor, 2-phenyl-5-methylbenzotriazole, 2,2'-hydroxy-5-methylphenanthrene, 2-(2'-hydroxy-5H-octylphenyl)-benzotriazole; 2-(2'-hydroxy-5'-methylphenanthrene), dinitolmide, 4-methoxy-4'-tert-butylbenzoate and 5-(3,3-dimethyl-2-norbornylene)-3-pentane-2-it. Also derivatives of pyridazine, such as disorganization.

The content of the ultraviolet absorber of radiation is determined in accordance with the target product, it is usually 1-25 wt.%, preferably 5-20 mass%, of the total number of skin cosmetic emulsion of the type "water in oil".

In addition to the above essential ingredients in cosmetic for the skin, in the form of an emulsion type water in oil" of the present invention it is possible to add other ingredients used in cosmetic products, if necessary; examples of such ingredients include moisturizers, water-soluble polymers, thickening agents, covering agents, exfoliating agents, polyhydric alcohols, sugars, amino acids, organic amines, polymer emulsions, pH regulators, nutrients for skin, vitamins, antioxidants, auxiliary substances against oxidation and perfume substances, and cosmetic for the skin, in the form of an emulsion type water in oil" may be prepared in the form of the final product about�CNIM.

Examples

The present invention is further described in the following examples. The present invention is not limited to these examples. Unless otherwise stated, the content of components expressed in percent by weight relative to the total number.

Sunscreens, which are skin cosmetic emulsion of the type "water in oil", were prepared in the usual way using the compositions shown in tables 1 and 2, and testing was conducted for the actual use involving a panel of ten experts to evaluate the texture when applied to the face based on the following criteria.

"The elimination of scriptsisti powder ingredient (e) over time (no scriptsisti powder one hour after application on the skin)"

Evaluation criteria

: 9-10 experts reported that there is no scriptsisti powder after an hour

application.

: 6-8 experts reported that there is no scriptsisti powder after an hour

application.

: 3-5 experts reported that there is no scriptsisti powder after an hour

application.

: 1-2 experts reported that there is no scriptsisti powder in an hour

after drawing.

: 0 the experts reported that there is no scriptsisti powder after an hour

application.

"Good absorption into the skin during application"

Evaluation criteria

: 9-10 experts reported that there is good absorption into the skin in

the time of application.

: 6-8 experts reported that there is good absorption into the skin during

application.

: 3-5 experts reported that there is good absorption into the skin during

application.

: 1-2 experts reported that there is good absorption into the skin in

the time of application.

: 0 experts reported that there is good absorption into the skin during

application.

"The lack of stickiness on the skin after applying"

Evaluation criteria

: 9-10 experts reported that there is a lack of stickiness after

application.

: 6-8 experts reported that there is an absence of stickiness after application.

: 3-5 experts reported that there is an absence of stickiness after application.

: 1-2 experts reported that there is a lack of stickiness after

: 0 experts reported that there is an absence of stickiness after application.

The results of tables 1 and 2 show that compared with comparative examples, the examples of the present invention are excellent in regard to all effects, i.e. "lack of scriptsisti powder in an hour after application, good absorption during application and the absence of stickiness after application".

Examples of cosmetic compositions for the skin in the form of an emulsion type water in oil" of the present invention are presented below.

Example 6: Sunscreen, ingredient, wt.%:

(1) (e) Gidrofobizirovannym zinc oxide 20

(2) (e) Gidrofobizirovannym titanium dioxide 2

(3) (e) Ethylhexylacrylate 7

(4) (C) Decamethylcyclopentasiloxane 10

(5) isopropyl myristate 5

(6) Mineral oil 1

(7) (d) Carboximetilcelulosa 2

(8) Net methylsiloxane polymer 5

(9) (f) a Polyester-modified silicone 4

(10) Organically modified bentonite 2

(11) (a) Water, purified by ion exchange balance

(12) Glycerin 2,5

(13) 1,3-butyleneglycol 5

(14) (b) Ethanol 5

(15) Venexia�anal 0,5

Method: components (1) to(10) were mixed and dispersively. Was then added the aqueous phase components (11) to(15) were mixed and dissolved, and stirred with obtaining the target of sunscreen.

Example 7: Sunscreen lotion (double layer type), ingredient, wt.%:

(1) (C) Decamethylcyclopentasiloxane 20

(2) (C) Isohexadecane 10

(3) Dimethylpolysiloxane (6 cSt) 5

(4) (f) a Polyester-modified silicone 2

(5) (d) Carboximetilcelulosa 0,5

(6) (e) Octocrylene 3

(7) (e) Ethylhexylacrylate 5

(8) (e) Gidrofobizirovannym zinc oxide 12

(9) (e) Gidrofobizirovannym titanium dioxide 5

(10) the Powder of spherical particles of polymethylmethacrylate 3

(11) Blockcopolymer Poperechnaya silicone and mesh silicone 3

(12) (a) Water, purified by ion exchange balance

(13) 2-amino-2-methyl-1,3-propandiol 1

(14) Phenylbenzimidazole acid 2

(15) Glycerin 2

(16) 1,3-butyleneglycol 3

(17) Paraben 0.2 to

(18) (b) Ethanol 5

Method: components (1) to(11) were mixed and dispersively. Was then added the aqueous phase components (12) to(18) were mixed and dissolved, and stirred to give the desired sunscreen lotion.

Example 8: Sunscreen lotion (double layer type), ingredient, wt.%

(1) (C) Isohexadecane 17

(2) Dimethylpolysiloxane (6 cSt) 5

p> (3) Glycerite-(caprylate-capret) 5

(4) (d) Carboximetilcelulosa 3

(5) (f) a Polyester-modified silicone 2

(6) Organically modified bentonite 0,4

(7) a Powder of spherical particles organopolysiloxane elastomer 10

(8) (e) Gidrofobizirovannym zinc oxide 15

(9) (e) Gidrofobizirovannym titanium dioxide 7

(10) (a) Water, purified by ion exchange balance

(11) tranexamic acid 2

(12) EDTA 0,2

(13) Xylitol 3

(14) 1,3-butyleneglycol 5

(15) Phenoxyethanol 0.5 to

(16) (b) Ethanol 3

Method: components (1) to(9) were mixed and dispersively. Was then added the aqueous phase components (10) to(16) were mixed and dissolved, and stirred to give the desired sunscreen lotion.

Industrial applicability

According to the present invention it is possible to obtain a cosmetic for the skin, in the form of an emulsion type water in oil", which added one, two or more powders selected from the group consisting of gidrofobizirovannogo titanium dioxide, gidrofobizirovannogo zinc oxide and gidrofobizirovannogo iron oxide, which eliminated scriptsisti powder (tactile sensation to the lack of smoothness) on the skin over time after application, improved absorption into the skin during application and improved the absence of stickiness after application to the skin.

It�somaticheskoe agent for the skin in the form of an emulsion type water in oil" of the present invention is particularly suitable as sunscreen, having excellent texture.

1. Cosmetic for the skin, in the form of an emulsion type water in oil" containing the following ingredients (a) to(e), where the specified cosmetic for the skin, in the form of an emulsion of the type water-in-oil emulsified (f) a polyester-modified silicone and the tool additionally added (g) of the absorber of ultraviolet radiation:
(a) water: 5-50 wt. %
(b) ethanol: 1-20 mass. %
(c) the volatile oil component: 2-50 wt. %
(d) carboximetilcelulosa of formula (1): 0.1-5 mass. %

(e) gidrofobizirovannym zinc oxide: 2-50 wt. %.

2. Cosmetic for the skin, in the form of an emulsion type water in oil" containing the following ingredients (a) to(e), where the specified cosmetic for the skin, in the form of an emulsion of the type water-in-oil emulsified (f) a polyester-modified silicone and the tool additionally added (g) of the absorber of ultraviolet radiation:
(a) water: 5-50 wt. %
(b) ethanol: 1-20 mass. %
(c) the volatile oil component: 2-50 wt. %
(d) carboximetilcelulosa of formula (1): 0.1-5 mass. %

(e) gidrofobizirovannym titanium dioxide, gidrofobizirovannym zinc oxide and gidrofobizirovannym iron oxide: 2-50 wt. %.

3. Cosmetic for the skin, in the form of an emulsion type water in oil" according to claim 1 or , specified cosmetic for the skin, in the form of an emulsion type water in oil" is a sun cream or sun lotion.



 

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41 cl, 11 ex, 11 tbl

FIELD: medicine, pharmaceutics.

SUBSTANCE: group of inventions concerns oral care compositions effective for treating dental hypersensitivity, and a method of treating using them. The composition contains a compound of formula I: M1-A-M2-B-M1; wherein M1 and M3 represent potassium (K); M2 represents Ti or titanium (Ti) oxide; A and B independently represent C2-C6 dibasic acid; and at least one orally acceptable solvent. The oral care composition has pH falling within the range of 2.0 to 7.0. There are also presented a version of the composition, which contains at least one additional desensitising agent, and a method of treating sensitive teeth with the use of this composition.

EFFECT: using the group of inventions provides the effective dental desensitisation by creating a protective barrier on the tooth surface and/or sealing the effective dental tubules effectively.

11 cl, 8 tbl, 12 dwg

FIELD: chemistry.

SUBSTANCE: invention relates to the field of organic chemistry, namely to novel pyridine derivatives of the general formula

and to their pharmaceutically acceptable salts, where R1 stands for (C1-6) alkyloxy, CN or halogen, R2 stands for a hydrogen atom, R3 stands for a hydrogen atom or (C1-6) alkyl, R4, R5, R6, R7 are similar or different and stand for a hydrogen atom or halogen. The invention also relates to the cosmetic application of the formula (I) compound.

EFFECT: novel pyridine derivatives, useful in the treatment of diseases associated with a receptor of androgens, are obtained.

9 cl, 1 tbl, 16 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to pharmaceutical composition for treating insomnia. Said composition includes root of Polygonum multiflorum and/or its extracts, seeds of Ziziphus spinosa and/or its extracts, mulberry fruit and/or its extracts, Ganoderma and/or its extracts, lily bulb and/or its extracts, Anemarrhena rhizome and/or its extracts, root of Salvia miltiorrhiza and/or its extracts, chrysanthemum flower and/or its extracts, Poria and/or its extracts and Albizia flower and/or its extracts. Invention also relates to application of said composition.

EFFECT: claimed invention provides sedative and soporific effect, contributes to memory stimulation.

17 cl, 6 tbl, 14 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: group of inventions refers to oral hygiene preparations. An oral care composition contains a) an aqueous phase; b) stannous tin ions dissolved in the aqueous phase; c) nitrates in the aqueous phase; wherein total nitrates is that a molar amount of nitrogen measured as a nitrate in the aqueous phase makes 1.8-0.1 of the molar amount of stannous tin ions; and d) a flavouring agent. What is also presented is a method for storage and a storage container for this composition; using nitrate for stabilising oxidised stannous tin ions dissolved in the aqueous phase. What is also presented is also a version of the composition, wherein the composition is aqueous.

EFFECT: using the group of inventions stabilises oxidised stannous tin ions dissolved in the aqueous phase by the above molar ratio of nitrate and stannous tin ions.

17 cl, 2 tbl, 15 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to the pharmaceutical industry, namely to a medication for the complex therapy of patients with type 2 diabetes mellitus and a method of the complex therapy of patients with type 2 diabetes mellitus. The medication for the complex therapy of patients with type 2 diabetes mellitus contains a cleaned and dried rhizome of Curcuma longa in the form of powder with the specified size of particles. The method of the complex therapy of patients with type 2 diabetes mellitus consists of the daily intake of the cleaned and dried rhizome of Curcuma longa in the form of powder with the specified size of particles twice per day after dinner and supper at the background of the intake of pelleted hypoglycaemic agents without changing the dose and scheme of the drug therapy.

EFFECT: medication produces a direct stimulating impact on β-cells of the pancreas and ensures the development of a hypoglycaemic effect, including early stages of the disease development.

3 cl, 1 dwg, 5 tbl

FIELD: chemistry.

SUBSTANCE: invention refers to using an oral composition containing steviol, which improves the human hair or animal fur/feather/scale look. Using steviol in preparing the oral composition of nutriceuticals or a nutrient composition for improving the human hair or animal fur/feather/scale look.

EFFECT: invention provides improving the human hair or animal fur/feather/scale look more effectively.

7 cl, 4 dwg, 5 tbl, 13 ex

FIELD: veterinary medicine.

SUBSTANCE: method comprises administering a homeopathic agent. The agent "Liarsin" is used, which is administered subcutaneously before calving into the biologically active points in the centre of the front and rear udder parts.

EFFECT: invention is highly effective for prevention of parturient paresis in cows.

4 cl, 2 tbl, 1 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to chemical-pharmaceutical industry and represents method of obtaining microcapsules of medication, which possess supermolecular properties, by method of precipitation with non-solvent, characterized by the fact that as medication applied is powder of unabi berries, preliminarily dissolved in butanol, as envelope - carrageenan, which is precipitated from solution in acetone by addition as non-solvent of ethanol and water, with the following drying at room temperature.

EFFECT: invention ensures simplification and acceleration of process of obtaining microcapsules, reduction of loss in the process of obtaining microcapsules (increase of output by weight).

2 ex, 18 dwg

FIELD: medicine.

SUBSTANCE: method includes the preparation of a carious cavity, opening the tooth cavity, creation of an access to root canals, extension of their orifice. Removal of a decayed material from the root canals and their drug treatment are carried out. After that, performed are: wide opening of the apical tooth orifice, mechanical and drug removal of periapical pathological exudative formations in the focus of periapical inflammation through the root canal. Before filling the canal with a filling material the gel "Lamifaren" is introduced into the focus of periapical destruction. Such introduction is performed three times after a day under temporary stopping. The gel "Lamifaren" is introduced inside in a dose of 50 g 2 times per day for 30 days.

EFFECT: application of the invention accelerates bone tissue regeneration due to the active release of an active substance calcium alginate, provides stable remission due to local and systemic detoxifying effect.

2 ex

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to methods of purification and health improvement of an organism. For this purpose therapeutic starvation for not fewer than 5 days in case of a 7-day programme and for not fewer than 7 days in case of a 9-day programme is carried out. The duration of a recovery period constitutes two days. Food intake is realised nine times per day each day both in the process of therapeutic starvation and in the recovery period. In the period of therapeutic starvation the first food intake includes bee products "APIGRANULES 2" in a dose of one teaspoon, "KHINAZI balm" in a dose of one teaspoon, "A-P-V" in a dose of one teaspoon, "APITOK" in a dose of one teaspoon, "Antihelm phyto" - one capsule and still mineral water - one glass. The second food intake includes a drink with ginger, lemon juice, garlic and mint, honey - one teaspoon and one glass of apple-carrot juice. The third food intake supposes an intake of bee products "APIGRANULES 2" in a dose of one teaspoon, "KHINAZI balm" in a dose of one teaspoon, "A-P-V" in a dose of one teaspoon, "Antihelm phyto" - one capsule and still mineral water - one glass. The fourth food intake includes a drink with ginger, lemon juice, garlic and mint, honey - one teaspoon and one glass of apple-carrot juice. The fifth food intake consists of tea black or green with ginger, one teaspoon of honey and one glass of apple-carrot juice. The sixth food intake consists of bee products "APIGRANULES 2" in a dose of one teaspoon, "A-P-V" in a dose of one teaspoon, "Antihelm phyto" - one capsule and one glass of still mineral water. The seventh food intake includes tea black or green with ginger, one teaspoon of honey and one glass of apple-carrot juice. The eighth food intake supposes an intake of tea black or green with ginger, one teaspoon of honey and one glass of apple-carrot juice. The ninth intake of food includes depressant tea, including mint grass, valerian root, fennel seeds, cumin seeds, epilobium or strawberry leaves and one glass of apple-carrot juice. In the recovery period in 1-st, 2-nd, 3-rd, 4-th and 6-th intakes of food the composition of products remains the same as in the process of starvation. For the fifth intake of food the patients take tea black or green with ginger, one teaspoon of honey and vegetable soup. For the seventh intake of food the patients take tea black or green with ginger, "MILK COCKTAIL WITH CHITOSAN". The eighth intake of food includes tea black or green with ginger, one teaspoon of honey, "APICAMPA" cereal. The ninth intake of food for the recovery period includes a baked apple, depressant tea. In addition, a number of procedures are carried out after each food intake during the period of therapeutic starvation and the recovery period. After the first food intake gymnastics "5 Tibetan pearls" is realised. After the second food intake exercises on training apparatuses, procedures of press-therapy, electrolypolysis and myostimulation are realised. After the third food intake exercises of therapeutic physical training or aerobics are performed. After the fourth food intake a rest in form of a walk, a halotherapy session, combined with a session of relaxation therapy are realised. After the fifth food intake a course of strip-plastic is carried out. After the sixth food intake massage by manual application with a peloid-based mixture or manual massage with honey is carried out. After the seventh food intake an infra-red sauna, shower, phytobath with medicinal herbs, honey, ginger, lemon juice is taken. After the eighth food intake a shower is taken.

EFFECT: method ensures effective health improvement of the organism with the preservation of the full value life style and a sense of a comfortable state in the starvation period, reduction of recovery period term after starvation, purification of the organism without loading on the gastrointestinal tract, weight loss, and improvement of the general state and workability of the patients.

3 tbl, 7 ex

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to oncology, and can be used for the treatment of local skin I-II degree radioreactions on irradiation fields after neutron therapy in patients with head and neck malignancies. For this purpose the applications of ozonised sunflower oil with peroxide number 18% and acid number 71 mg KON/g are performed on the area of the affected skin. The impact is performed after a session of neutron therapy 1-2 times per day for 4-5 days.

EFFECT: method ensures the reduction of the number of radioreactions and skin injuries due to optimally selected parameters of the applied medication, capable of the fast arrest of pain syndrome, reduction of oedema of surrounding tissues, wound-healing action in specific irradiation conditions.

4 dwg, 1 ex

FIELD: chemistry.

SUBSTANCE: invention relates to versions of cationic polyelectrolytic composition for application in personal care products and household chemicals and method of its obtaining. Composition includes: 1) cationic synthetic water-soluble polyelectrolyte, which contains (meth)acrylamide polymer and one or several of the following substances: I) cationic (meth)acrylamide monomer, and II) cationic monomer of (meth)acrylic acid, and III) hydrolysis-resistant cationic monomers, where polyelectrolyte has weight average molecular weight from approximately 10000 to approximately 2000000, charge density from, 0.001 to 2.5 meq./g, and level of acrylamide monomer that did not react constitutes less than 50 ppm, 2) surface-active substance and 3) solvent.

EFFECT: preparations, obtained on the base of composition, possess higher transparency.

17 cl, 3 dwg, 12 tbl, 106 ex

FIELD: medicine, oncology, amino acids.

SUBSTANCE: invention relates, in particular, to the development of an antitumor preparation based on natural substances. Invention relates to an amino acid preparation comprising at least one modified essential amino acid obtained by treatment of amino acid by ultraviolet radiation (UV) at wavelength 250-350 nm for 12-80 h at temperature 15-30oC or with ozone at temperature 15-25oC. The modified amino acid has no toxicity for health cells. Also, invention relates to a method for preparing such preparation. Invention provides the development of an antitumor preparation based on modified amino acids and expanded assortment of antitumor preparations being without cytotoxicity for normal cells.

EFFECT: valuable medicinal antitumor properties of preparation.

8 cl, 4 tbl, 2 dwg, 4 ex

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