Method for structure functional heart study and chronic cardiac failure diagnosis by means of high-frequency electrical impedance analysis
SUBSTANCE: method consists in diagnosing chronic cardiac failure. The diagnostic procedure involves using the high-frequency electrical impedance analysis. Bipolar measurements of electrical impedance of the chest involve recording average modular impedance |Z| and phase angle φ, and calculating the relation |Z|/|φ|. The measurements taken involve probing with AC current at frequencies 50, 100, 200 and 500 kHz. That implies using electrocardiographic electrodes 21 mm in diameter. The first electrode is placed in the 3rd intercostal space along the left parasternal line. The second one is placed series in three positions. For the first time, the second electrode is placed in the 2nd intercostal space along the left sternal line, lead 3-2. Then, in the 3rd intercostal space along the right parasternal line, lead 3-3. Thereafter in the 5th or 6th intercostals space on the left in a projection of apex beat, lead 3-5. Decreasing angle φ modulus at frequency 200 kHz in lead 3-2 less than 34°, and/or increasing the relation |Z|/|φ| measured at frequency 200 kHz in lead 3-3 more than 15, and/or decreasing the relation |Z|/|φ| measured at frequency 200 kHz in lead 3-5 less than 10 enable diagnosing chronic cardiac failure.
EFFECT: method increases the diagnostic accuracy ensured by measuring combined with recording the above parameters.
The invention relates to medicine, namely to cardiology, and is intended to improve the accuracy of diagnosis of chronic heart failure (CHF).
The closest analogue is the method of early diagnosis of chronic heart failure (RF Patent No. 2499553 IPC A61B 5/053, publ. November 27 2013 the Authors Mishlanov V. Yu., etc.). Method for early diagnosis of chronic heart failure of the person based on the registration of the two parameters of electrical impedance of the thorax and modular values of |Z| and the angle φ is the frequency of the probing AC electric current of 100 kHz bipolar method, provided the electrodes on the surface of the chest in the III-VI intercostal space on the left and right parasternal lines. Thus the diagnosis of heart failure is carried out by calculating the ratio |Z|/|φ| and its increase more than 5 times.
The disadvantages of the prototype method are the limited range of diagnostic possibilities, namely the impossibility of diagnosing systolic heart failure, the lack of evaluation of the volumes of the chambers and other structures of the heart, which is associated with the position of the electrodes on the chest and the application of the study of the electrical impedance of only a single frequency of the probing AC electric current.
The invention is directed �and the solution to the problem of increasing the accuracy of the method and to expand the diagnostic capabilities of the method due to the diagnosis of systolic heart failure and evaluation of structural-functional state of the heart.
The problem is solved with the help of the features specified in the claims, in common with the prototype, such as a method of structural-functional studies of the heart and the diagnosis of chronic heart failure using high-frequency electrical impedance analysis using a bipolar method of measuring electrical impedance of the thorax and recording the average values of modular values of impedance |Z| and phase angle φ, the calculation of the ratio |Z|/|φ|, and distinctive essential features, such as the measurement is performed with the sensing alternating current frequencies 50, 100, 200 and 500 kHz, using electrocardiographic electrodes, with a diameter of 21 mm, the first of which is applied in the third intercostal space along the left parasternal line, and the second successively in three positions: the first time - in the II intercostal space on the left sternal line (lead 3-2, then in the third intercostal space on the right parasternal line (lead 3-3), then in the fifth or sixth intercostal space to the left in the projection of the apical impulse (lead 3-5), and by reducing the angle φ at a frequency of 200 kHz in lead (3-2) less than 34° diagnose pulmonary arterial hypertension, with increase of the ratio |Z|/|φ|, measured at a frequency of 200 kHz in lead (3-3), more than 15 are diagnosed with myocardial hypertrophy of the left ventricle, for reducing the ratio |Z|/φ|, measured at a frequency of 200 kHz in lead (3-5), less than 10 diagnosed dilatation of the left ventricle, for reducing the ratio |Z|/|φ|, measured at a frequency of 200 kHz in lead (3-5), less than 8 diagnose reduced ejection fraction of the left ventricle less than 50% and corresponding to these structural and functional changes in chronic heart failure.
The technical result of the above, the essential features is the possibility of structural and functional studies of the heart, the diagnosis of chronic heart failure and increasing accuracy.
The invention is illustrated by the following examples:
Example 1. General conditions diagnosis:
- measurement of electrical impedance of the thorax is performed bipolar method (by combining current and potential electrodes or the use of bipolar rheographic devices) the impedance Measurement is performed by the analyzer with the appropriate characteristics, for example Madass ABC-01 or other (Device for measuring impedance of biological media", Russian Federation Patent No. 2462185 from before 19.07.2011 IPC A61B 5/08, publ. 27.09.12 G. the Authors Sudakov A. I., Shakirov N. In., Zuyev A. L., Milanov V. Y.);
- electrodes mounted on the chest in the projection of the main chambers of the heart and/or major blood vessels right and left of the sternum, for example �used the first position of the electrode in the third intercostal space along the left parasternal line and the different positions of the second electrode by sternal line at the left second intercostal space (the symbol of abstraction - 3-2), parasternal line to the right in the third intercostal space (the symbol of abstraction - 3-3); in the apex of the heart in the V intercostal space to the left (callout abduction - 3-5).
- apply round the electrodes of technical steel (diameter 2.1 cm) with suction cups; measuring an electrical impedance is carried out at frequencies of the probing AC electric current from 50 to 500 kHz with simultaneous recording of modular values of impedance |Z|, phase angle φ and calculate the ratio |Z|/|φ|;
- recommended duration of measurement is not less than 1 minute with the determination of not less than 576000 values and by averaging the obtained results.
The measured values of the modular values of electrical impedance match the diameter of the large pulmonary vessels, aorta or heart chambers - the main conductors of electric current and depends on their changes in the cardiac cycle. The angle φ reflects the capacitance of the various components of the chest, primarily pleural leaflets and pericardium, consisting of dense fibrous connective tissue, and also depends on the thickness of the myocardium of the ventricles and the cellular composition of tissues. The increase in modular value of the electrical impedance |Z| corresponds to a reduction pomatiopsidae-section of a conductor of electric current - major blood vessel or chamber of the heart, according to known physical law expressed by the formula:
where XL- inductive reactance, XCcapacitive reactance, ρ is the specific active electrical resistance, L is the length of the interelectrode distance, S is the cross sectional area of a conductor of electric current.
The method is as follows. The patient is in the supine position. Electrodes with a diameter of 2.1 cm with suction cups for electrocardiographic studies made of steel technical, moisten with running water and apply on the surface of the chest in the projection of large vessels or chambers of the heart, for example, the first electrode is on the left parasternal line in the third intercostal space, and the second in II intercostal space to the left of the sternum (lead 3-2), or parasternal line in region III intercostal space right of sternum (lead 3-3), or in the projection of the apex of the heart in the fifth or sixth intercostal space to the left (lead 3-5). Start the registration of the electrical impedance at the frequency of the probing AC electric current of low power 50, 100, 200, 500 kHz and save the result in 1 minute average values of |Z| and |φ|, and calculate the ratio |Z|/|φ|. By reducing the angle φ at a frequency of 200 kHz in lead (3-2) less than 34° d�Instituut pulmonary arterial hypertension, with increase of the ratio |Z|/|φ|, measured at a frequency of 200 kHz in lead (3-3), more than 15 are diagnosed with myocardial hypertrophy of the left ventricle, for reducing the ratio |Z|/|φ|, measured at a frequency of 200 kHz in lead (3-5), less than 10 diagnosed dilatation of the left ventricle, for reducing the ratio |Z|/|φ|, measured at a frequency of 200 kHz in lead (3-5), less than 8 diagnose reduced ejection fraction of the left ventricle less than 50% and corresponding to these structural and functional changes in chronic heart failure.
The study included 24 patients with cardiovascular diseases, including 10 men, 14 women, 3 had isolated arterial hypertension of the 2nd degree, 16 - combined for hypertension 2-3 degrees and angina 2-3 functional class, 5 - isolated angina 2 functional class. All the patients underwent echocardiography and high-frequency electrical impedance analysis of cardiac hemodynamics. The results were processed using the software package Statistica 8.0. Using correlation analysis found a significant relationship between the magnitude of the modulus of the angle φ, measured in lead (3-2) at the frequency of the probing AC 200 kHz, and the mean pressure in the pulmonary artery, r=-0,98, p=0,0027; between the value of the ratio of� |Ζ|/|φ|, measured in lead (3-3) at a frequency of 200 kHz, and the values of the thickness of the interventricular septum and the posterior wall of the left ventricle, r=0,61, p=0,0159, and r=0,71, p=0,0030, respectively; between the value of the ratio |Ζ|/|φ|, measured in lead (3-5) at a frequency of 200 kHz, and the value of the final systolic size of the left ventricle, end-diastolic size of the left ventricle, end-systolic left ventricular volume and end-diastolic left ventricular volume, myocardial mass, left ventricular mass index left ventricular myocardium, as well as the size of the ejection fraction of the left ventricle (r=-0,69, p=0,0046; r=-0,60, p=0,0187; r=-0.67, p=0,0081, r=-0,64, p=0,0133, r=-0,58; p=0,0226, r=-0,60, p=0,0173, r=0,79, p=0,0004, respectively). The sensitivity (frequency detection) reference method of diagnosis of chronic heart failure amounted to 95.8%, the new method is 100%. The above example shows that the new method for the diagnosis of heart failure exceeds the reference method for the detection rate of the disease in comparison with echocardiographic method, due to the simultaneous recording of a set of attributes, namely the reduction of the magnitude of the angle φ at a frequency of 200 KHz in the 3-2 lead less than 34° and/or increase the ratio |Ζ|/|φ|, measured at a frequency of 200 kHz in lead 3-3, 15, and/or reduce the ratio |Ζ|/|φ|, edit�bedrock at a frequency of 200 kHz in lead 3-5, less than 10.
Patient A., aged 57. The diagnosis of coronary artery disease, myocardial infarction (2009), coronary bypass surgery (2 of shunt, 2009). OSL.: Chronic heart failure 3 f.to. (NYHA classification). Growth 169 cm, weight 65 kg, BMI of 22.8. Measured using high frequency analysis of cardiac hemodynamics values of electrical impedance of the thorax made: in the lead (3-2) at a frequency of 200 kHz, the angle φ=63,9° abduction (3-3) at a frequency of 200 kHz the ratio |Z|/|φ|=15,1, in lead (3-5) at a frequency of 200 kHz the ratio |Z|/|φ|=a 13.9. Echocardiographic method 21.12.2013. revealed: obtained were compared=16 mm Hg.CT., TSKJ=1.4 cm, ssli=1.2 cm; CEB LV=44 mm, CEB LV=32 mm, CSR LV=41 cm3, EDV LV=88 cm3, MLG=215,1 g, lvmwi=112 g/m2, LV EF=53%. Conclusion: pulmonary arterial hypertension have not been identified, signs of concentric left ventricular hypertrophy, contractility of the left ventricle satisfactory.
Patient A., age 78; diagnosis: coronary heart disease, heart rhythm disorder type permanent tachysystolic forms of atrial fibrillation. OSL.: chronic heart failure 3 f.to. (NYHA classification). Growth 169 cm, weight 69 kg, BMI of 24.2. Measured using high frequency analysis of cardiac hemodynamics values of electrical impedance of the thorax made: in the lead (3-2) at a frequency of 200 kHz, the angle φ=62,1° abduction (3-3) at a frequency of 200 kHz �elations |Z|/|φ|=9,3, in lead (3-5) at a frequency of 200 kHz the ratio |Z|/|φ|=9,2. Echocardiographic method 21.12.2013. revealed: obtained were compared=24 mm Hg.CT., TSKJ=0.9 cm, ssli=0.8 cm; CEB LV=55 mm, CEB LV=75 mm, CSR LV=159 cm3, EDV LV=294 cm3, MLG=297,5 g, lvmwi=151,1 g/m2, LV EF=48.8 PER CENT. Conclusion: pulmonary arterial hypertension have not been identified, dilatation of the left ventricle contractility of the left ventricle is reduced.
The presented examples demonstrate the relationship of the clinical picture of the disease, accompanied by clinical signs of chronic heart failure, echocardiographic data on the availability of structural and functional disorders and altered results of electrical impedance characteristics of cardiac hemodynamics.
From the description and practical application of the present invention to specialists will be obvious and other private forms of its implementation the above description and examples are considered as material illustrating the invention, the essence of which and the scope of patent claims is defined in the following claims, the set of essential features and their equivalents.
A method for diagnosing chronic heart failure using high-frequency electrical impedance analysis using a bipolar method of measuring electrical impedance of the thorax and registration�radiation averages modular impedance values of |Ζ| and phase angle φ, the calculation of the ratio |Ζ|/|φ|, characterized in that the measurement is performed with a sensing alternating current frequencies 50, 100, 200 and 500 kHz, using electrocardiographic electrodes with a diameter of 21 mm, the first of which is set in the third intercostal space along the left parasternal line, and the second successively in three positions: the first time - in the II intercostal space on the left sternal line, the lead 3-2, then in the third intercostal space on the right parasternal line, assignment 3-3, then in the fifth or sixth intercostal space to the left in the projection of the apical impulse, abduction 3-5, and with a decrease of the modulus of the angle φ at a frequency of 200 kHz in the 3-2 lead less than 34°, and/or increasing the ratio |Ζ|/|φ|, measured at a frequency of 200 kHz in lead 3-3, 15, and/or reduce the ratio |Ζ|/|φ|, measured at a frequency of 200 kHz in lead 3-5, less than 10 diagnosed with chronic heart failure.
SUBSTANCE: method involves measuring an electric potential, performing the mechanical processing of involves dental tissues, and therapeutic treatment. The electric potential is measured in any of acupuncture points (AP) found on the face and connected to the involved teeth. The mechanical processing is performed with using an excavation burr. The electric potential is measured in the acupuncture points throughout the whole mechanical processing of the teeth every 5 seconds. If observing a drastic fall of the electric potential by more than 5 mV has the therapeutic effect on the teeth by terminating the mechanical processing of the teeth and continuing it at a lower rpm.
EFFECT: method provides the higher clinical effectiveness by reducing the pain sense in the patient by controlling the electric potential measurement continuously in one of any acupuncture points found on the face and connected to the involved teeth.
4 dwg, 2 ex
SUBSTANCE: group of inventions refers to medicine, namely to paediatrics, and can be used to control an amount of breast milk consumed by a nursing infant. The method involves measuring a breast electric resistance and a breast electric capacity before and after breastfeeding. The derived values are multiplied to obtain the characteristics variation information during the breastfeeding. The change information are related to the amount of milk consumed by the infant. What is presented is a breastfeeding control system, which comprises an electric capacity measuring unit designed for measuring the electric capacity variations before and after breastfeeding. Besides, the system comprises a breast electric resistance measuring unit. Also, the system comprises a processing unit configured to calculate the product of the electric capacity and the electric resistance, and to match the derived product with the amount of milk consumed by the nursing infant.
EFFECT: inventions enables controlling the amount of breast milk consumed by the infant and assessing the adequacy of breastfeeding.
16 cl, 20 dwg, 3 ex
SUBSTANCE: method involves preliminary assessment of the reversible abnormal changes of enamel accompanying early cariosity. That is ensured by diagnostic tests of solid dental tissues conducted by using light-induced fluorescence and electrometric measurement techniques followed by therapy involving daily applications of the Radogel-GABA preparation. If observing visually detected changes with a current intensity of 0.21-1.99 mcA in the lesion and the presence of fluorescence, the preclinical changes of enamel are diagnosed requiring 5 therapeutic procedures with the above preparation. Visualised tarnishing of enamel accompanied by a current intensity of 2.00-3.99 mcA in the lesion and the presence of fluorescence, an early carious change of enamel at the stage of a dead spot is diagnosed, and 7 therapeutic procedures are conducted. If visualising a white spot of enamel accompanied by a current intensity of 4.00-5.99 mcA in the lesion and the presence of fluorescence, an early carious change of enamel at the stage of a white spot is diagnosed, and 10 therapeutic procedures are conducted. If visualising a white spot of enamel accompanied by a current intensity of 6.00-7.99 mcA in the lesion and the presence of fluorescence, an early carious change of enamel at the stage of an intense white spot is diagnosed, and 15 therapeutic procedures with the Radogel-GABA preparation are required.
EFFECT: method provides the high-effective therapeutic exposure on caries by the timely recovery of the protein dental matrix with simplicity and ease of use at massive dental visits.
SUBSTANCE: invention is related to systems of magnetic impedance tomography. The system comprises an excitation system having several exciting coils to generate a magnetic excitation field intended to induce eddy currents in a surveyed volume, a measurement system with several measuring coils to measure the fields generated by the induced eddy currents, at that the measuring coils are placed in a volumetric (3D) geometrical assembly and a reconstruction device intended for the receipt of measurement data from the measurement system and for the reconstruction of the object imaging in the surveyed volume against the measured data. Each measuring coil covers an area and is oriented in essence transversely to the magnetic field power lines in the exciting coils, separate measuring coils cover jointly the area corresponding to the volumetric (3D) geometrical assembly, at that the exciting coils cover the area where the measuring coils are placed. The area covered by each of the separate measuring coils is oriented perpendicular to the area covered by the exciting coils.
EFFECT: usage of the invention allows improving the quality of imaging for volumetric objects.
8 cl, 2 dwg
SUBSTANCE: group of inventions refers to medicine. A device comprises: a measuring device, a calculation device and an input device. Implementing the method involves extracting the living body information measured by the measuring device. The input device is used to accept the biological component information measured by the other device together with the date and time information. That is followed by determining if the biological component information is actual. If the biological component information is stated to be actual, the calculation device is used to calculate the biological information by formula: f(ρ)=a2·1/ρ+b2·W+c2·S+d2·L+e2. If the biological component information is stated to be inactive, the calculation procedure follows formula: f(ρ)=a1·1/ρ+b1·W+c1. Herewith, a1-c1, a2-e2 are the pre-set constants, ρ is a living body's specific resistance, S is a body part cross-section, L is a body part length, W is a living body weight.
EFFECT: group of inventions enables providing the more accurate body composition measurement by using the data extracted by the other devices.
8 cl, 14 dwg
SUBSTANCE: invention refers to medicine, forensic medicine, diagnostic measurements, including in investigative practice. An interactive psychophysiological testing (PPT) involves presenting a person being tested test questions, determining, analysing the psychogenesis parameters with using the person's physical parameter sensors, indicating the results and estimating. The test questions are typed as follows: first-version questions Q1, second-version questions Q2, neutral questions N. The questions Q1 and Q2 have an alternative meaning and equal power and are characterised by an equal presentation time, a consistency of comparing the questions according to the alternative versions, a minimised subjective personal effect of the PPT test expert by sound colour and level, an unconscious emotional support on the person's question perception, as well as an identity of putting the questions to be compared, their length and a fixation of the meaningful word and/or word combination in similar segments of both questions to be compared. The test is put in accordance with a concatenation as follows X:0→C,…,C→Q11.Q21→N→ →Q21.Q22→N→…→Q1n.Q2n→N, wherein X is a person's identification index; 0 is a non-estimated zero question; C is a question relieving an expectation stress; Q1i is the first-version question, wherein i=1, 2,…, n; Q2i is the second-version question, wherein i=1, 2,…, n; N is a neutral question; n is a number of specific circumstances of the event or action; ":", "→", "." are devisors. The questions are put taking into account the staging of the tested event, including the confirmed facts or data only and excluding the expert's conjectures or versions. The results are used to state one of the two alternative versions and to estimate the respective status of the person being tested. The psychogenesis is determined and analysed with using a polygraph, while putting the questions of the two alternative versions, indicating and processing the PPT data are conducted with a computer with relevant software.
EFFECT: method provides higher information value, accuracy, reliability, objectiveness of the PPT results as compared to the previously known tests up to 90-95% with avoiding the distortion and ambivalence of the results.
5 cl, 1 dwg
SUBSTANCE: technique involves impedancemetry accompanying surgical intervention. A one-side ingrown nail requires measuring an impedance of the involved and healthy nail folds. The measurements are taken at a frequency 2 of kHz and voltage 1 V. A coefficient K is calculated as a relation of the involved to healthy impedances. The value K of 1.5 or less testifies to an inflammatory reaction.
EFFECT: technique simplifies diagnostics and reduces its time.
2 ex, 1 dwg, 1 tbl
SUBSTANCE: method involves measuring an enamel electrical conductivity and assessing a light-induced fluorescence of a dental tissue in the lesion. A current intensity within the lesion of no more than 0.2 mcA and the absence of the enamel glow testify to the enamel intactness with zero points assigned. The current intensity of 0.21 to 1.99 mcA and the enamel glow testify to the preclinical enamel changes with 0.1 points assigned. The current intensity of 2.0 to 3.99 mcA and the enamel glow testify to primary caries changes at the stage of dead spot with 0.4 points assigned. The current intensity of 4.0 to 5.99 mcA and the enamel glow testify to primary caries changes at the stage of dead spot with 0.7 points assigned. The current intensity of 6.0 to 7.99 mcA and the enamel glow testify to primary caries changes at the stage of deep white spot with 1 point assigned. A dental tissue resistance index (RIdt) is calculated by formula: RIdt=(F0×0+F1×0.1+F2×0.4+F3×0.7+F4×1)/n, wherein F0 is the number of teeth with the intact enamel; F1 is the number of teeth with the preclinical enamel changes ; F2 is the number of teeth with caries enamel changes at the stage of dead spot; F3 is the number of teeth with caries enamel changes at the stage of white spot; F4 is the number of teeth with caries enamel changes at the stage of deep white spot; n is the number of intact teeth having preclinical and early clinical changes. The index is calculated prior to and after the therapeutic-preventive course. A positive difference of the indices prior to and after the therapeutic course testifies to the adequacy of the conducted therapy. The above difference being zero or less testifies to the necessity of the recurrent course or changes in the therapy.
EFFECT: method provides assessing the dental tissues taking into account the preclinical and early changes.
1 tbl, 1 ex
SUBSTANCE: invention refers to medicine. A device for real-time electrodermal skin activity test comprises electrodes with fasteners, an input element, a filter, the first and second dispersion evaluators, an expectation evaluator, the first and second variation coefficient evaluators, a subtractor, a threshold former, a comparator, and a counter.
EFFECT: invention provides higher reliability and accuracy of the real-time electrodermal activity and psychoemotional status test with relaxation in the hardware requirements and a possibility to separate relatively slowly varying phase components.
SUBSTANCE: arm impedance variation is recorded in the hemodynamic load generated with a patient standing by raising arms upward, keeping arms in this position and returning to a normal position and lowering along the body. A period of time of the vertical standing with the arms raised upwards makes 30 seconds. After the arms are returned to the normal position, electrical impedances are recorded 10 seconds later, and a recovery index (RI) is determined by the original formula. If RI≤1, a norm is stated, while RI>1 enables stating the presence of atherosclerotic changes, a manifestation of which is stated by an excess.
EFFECT: method enables norming the time parameters of hemodynamic load and obtaining the qualitative assessment of the functional status of the arterial blood flow to enable the early instant diagnosis of developing atherosclerosis.
3 dwg, 1 tbl
SUBSTANCE: method involves carrying out urological examination for determining hydrodynamic resistance of ureter calculated from formula Z=8Lμ/(πR4), where Z is the hydrodynamic resistance of ureter, L is the ureter length, R is the ureter radius, μ is the urine viscosity. Angle α at which the ureter enters the urinary bladder is determined from formula cosα = 8l1μ/(ZπR4), where l1 is the perpendicular drawn from the upper edge of the ureter to the its exit projection line, μ is the urine viscosity, Z is the hydrodynamic resistance of ureter, R is the ureter radius. Vesicoureteral reflux recidivation is predicted when the angle of α+90° is less than 120°.
EFFECT: enhanced effectiveness in reducing the number of recidivation cases.
2 dwg, 1 tbl
SUBSTANCE: one should measure electric impedance of patient's middle ear. Electrodes should be applied in three localizations: auditory canal, anterior end of lower nasal concha and frontal skin. Electric impedance should be measured at the frequencies of sinusoidal signal being equal to 10, 30, 250 and 1000 Hz, the data obtained should be compared by values of electric impedance in the given area (middle ear) in the group of healthy patients. This method provides the chance to obtain comparative data for diagnostics of middle ear diseases.
EFFECT: higher accuracy of evaluation.
FIELD: medicine; medical engineering.
SUBSTANCE: method involves doing multi-channel recording of electroencephalogram and carrying out functional tests. Recording and storing rheoencephalograms is carried out additionally with multi-channel recording of electroencephalogram synchronously and in real time mode in carotid and vertebral arteries. Electroencephalograms and rheoencephalograms are visualized in single window with single time axis. Functional brain state is evaluated from synchronous changes of electroencephalograms, rheoencephalograms and electrocardiograms in response to functional test. The device has electrode unit 1 for recording bioelectric brain activity signals, electrode unit 2 for recording electric cardiac activity signals, current and potential electrode unit 3 for recording rheosignals, leads commutator 4, current rheosignal oscillator 5, synchronous rheosignal detector 6, multi-channel bioelectric brain activity signals amplifier 7, electrophysiological signal amplifier 8, demultiplexer 9, multi-channel rheosignal amplifier 10, multi-channel analog-to-digital converter 11, micro-computer 12 having galvanically isolated input/output port and personal computer 13 of standard configuration.
EFFECT: enhanced effectiveness of differential diagnosis-making.
11 cl, 6 dwg
FIELD: medical engineering.
SUBSTANCE: device has acting upon skin between electrodes with DC potential of given magnitude for producing temporary breakdown. Skin impedance is measured between measuring electrode first negatively polarized relative to control electrode and the control electrode, and then, DC current resistance is measured once more by means of measuring electrode positively polarized relative to the control electrode. Ratio of the obtained values is used for determining internal organ health state, corresponding to skin area.
EFFECT: enhanced accuracy of diagnosis.
11 cl, 14 dwg, 2 tbl
FIELD: poultry science.
SUBSTANCE: the present innovation deals with visual evaluation in chicken followed by testing them by the value of bioelectric potential. Chickens with bioelectric potential being significantly higher against average values are considered to be stress-resistant ones and those with bioelectric potential being significantly lower against average values in concrete population are concluded to be stress-sensitive ones. The method is very simple in its implementation and efficient for large-scale selection in poultry on stress-resistance.
EFFECT: higher efficiency.
1 cl, 2 dwg, 2 ex, 4 tbl
SUBSTANCE: the method deals with measuring geometric body size and electric impedances of patient's hands, body and legs at their probing with low- and high-frequency current due to current and potential electrodes applied onto distal parts of limbs, and, thus, detecting extracellular, cellular and total volumes of liquid in patient's hands, body and legs. While implementing the method one should additionally apply current electrodes onto left-hand and right-hand parts of neck, and potential electrodes - onto distal femoral parts. Body impedance (Zb) should be measured due to successive measuring the impedance of its right-hand Zrb and left-hand Zlb parts at probing current coming between electrodes of similar sides of patient's neck and legs to detect Zb, as Zb = Ѕ x (Zrb + Zlb), impedance of legs Zl should be detected due to measuring femoral impedance Zf and that of shins Zs, as Zl = Zf + Zs. At detecting the volumes of liquid in body and legs one should apply measured values of Zb and Zl, moreover, as geometric body size one should apply the distance against the plane coming through the upper brachial surface up to the middle of radiocarpal articulation in case of patient's hand being along the body.
EFFECT: higher accuracy of detection.
5 dwg, 2 ex, 3 tbl
FIELD: medicine; medical engineering.
SUBSTANCE: method involves applying electrodes to injured extremity tissue under study. The electrodes are arranged in diametrically opposite points of horizontal plane transaction to extremity surface. Two electrodes are applied to the other extremity. The electrodes are arranged in diametrically opposite points of horizontal plane transaction to extremity surface. An initial point is selected relative to which pairs of electrodes are equidistantly arranged on the extremity. Active and reactive impedance components are measured at the places of electrodes positioning. Viability condition of the injured extremity tissue under study is diagnosed depending on ratio of reactive to active impedance component on injured and intact extremity and difference between reactive impedance component on injured and intact extremity. Device has transducer unit, computer and unit for processing signals having interface units, central subscriber station, autonomous transmission center, commutator which input is connected to transducer unit output and commutator output is connected to central subscriber station input, the first input is connected to autonomous transmission center output.
EFFECT: high accuracy in diagnosing biological object condition.
5 cl, 5 dwg, 4 tbl
FIELD: medicine, psychotherapy.
SUBSTANCE: the method deals with correcting neurological and psychopathological disorders with anxiety-phobic symptomatics due to individual trainings. The method includes evaluation of body reaction to stimulating signals, seances of individual training performed due to the impact of two quasiantipodal stimulating signals of similar physical modality applied in time of sporadic character, and as a signal one should present biological feedback for the altered value of physiological parameter adequately reflecting body reaction to the impact of stimulating signal. At the first stage of training it is necessary to achieve body adaptation to the impact of quasiantipodal stimulating signals, at the second stage it is necessary to obtain conditional reflex for one out of stimulating signals, for this purpose one should accompany this stimulating signal with discomfort impact, during the third stage, finally, due to volitional efforts one should suppress body reaction to stimulating signal. The devise suggested contains successively connected a transformer of physiological parameter into electric signal and a bioamplifier, an analysis and control block with a connected block to present the signals of biological feedback, a block for presenting discomfort impact, an indication block and that of forming and presenting quasiantipodal stimulating signals. The innovation enables to have skills to control one's emotions, decrease sensitivity threshold to environmental impacts and learn to how behave during stress situations.
EFFECT: higher efficiency of training.
15 cl, 8 dwg
FIELD: medicine; medical engineering.
SUBSTANCE: method involves recording multichannel electroencephalogram, electrocardiogram record and carrying out functional test and computer analysis of electrophysiological signals synchronously with multichannel record of electroencephalogram and electrocardiogram in real time mode. Superslow brain activity is recorded, carotid and spinal artery pools rheoelectroencephalogram is recorded and photopletysmogram of fingers and/or toes is built and subelectrode resistance of electrodes for recording bioelectrical cerebral activity is measured. Physiological values of bioelectrical cerebral activity are calculated and visualized in integrated cardiac cycle time scale as absolute and relative values of alpha-activity, pathological slow wave activity in delta and theta wave bandwidth. Cerebral metabolism activity dynamics level values are calculated and visualized at constant potential level. Heart beat rate is determined from electrocardiogram, pulsating blood-filling of cerebral blood vessels are determined from rheological indices data. Peripheral blood vessel resistance level, peripheral blood vessel tonus are determined as peripheral photoplethysmogram pulsation amplitude, large blood vessel tonus is determined from pulse wave propagation time data beginning from Q-tooth signal of electrocardiogram to the beginning of systolic wave of peripheral photoplethysmogram. Postcapillary venular blood vessels tonus is determined from constant photoplethysmogram component. Functional brain state is determined from dynamic changes of physiological values before during and after the functional test. Device for evaluating functional brain state has in series connected multichannel analog-to-digital converter, microcomputer having galvanically isolated input/output ports and PC of standard configuration and electrode unit for reading bioelectric cerebral activity signals connected to multichannel bioelectric cerebral activity signals amplifier. Current and potential electrode unit for recording rheosignals, multichannel rheosignals amplifier, current rheosignals generator and synchronous rheosignals detector are available. The device additionally has two-frequency high precision current generator, master input of which is connected to microcomputer. The first output group is connected to working electrodes and the second one is connected to reference electrodes of electrode unit for reading bioelectrical cerebral activity signals. Lead switch is available with its first input group being connected to potential electrodes of current and potential electrodes unit for recording rheosignals. The second group of inputs is connected to outputs of current rheosignals oscillator. The first group of outputs is connected to current electrodes of current and potential electrodes unit for recording rheosignals. The second group of outputs is connected to inputs of synchronous detector of rheosignals. Demultiplexer input is connected to output of synchronous detector of rheosignals and its outputs are connected to multichannel rheosignals amplifier inputs. Outputs of multichannel bioelectrical cerebral activity signals amplifier, multichannel rheosignals amplifier and electrophysiological signal amplifier are connected to corresponding inputs of multichannel analog-to-digital converter. Microcomputer outputs are connected to control input of lead switch, control input of multichannel demultiplexer, control input of multichannel analog-to-digital converter and synchronization inputs of current rheosignals oscillator and synchronous detector of rheosignals. To measure subelectrode resistance, a signal from narrow bandwidth current generator of frequency f1 exceeding the upper frequency fup of signals under recording is supplied. A signal from narrow bandwidth current generator of frequency f2≠ f1>fup is supplied to reference electrode. Voltages are selected and measured at output of each amplifier with frequencies of f1, f2 - Uf1 and Uf2 using narrow bandwidth filtering. Subelectrode resistance of each working electrode is determined from formula Zj=Ujf1 :(Jf1xKj), where Zj is the subelectrode resistance of j-th electrode, Ujf1 is the voltage at output from j-th amplifier with frequency of f1, Kj is the amplification coefficient of the j-th amplifier. Subelectrode resistance of reference electrode is determined from formula ZA=Ujf2 :(Jf2xKj), where ZA is the subelectrode resistance of reference electrode, Ujf2 is the voltage at output from j-th amplifier with frequency of f2, Jf2 is the voltage of narrow bandwidth current oscillator with frequency of f2.
EFFECT: wide range of functional applications.
15 cl, 10 dwg
FIELD: medical engineering.
SUBSTANCE: device has divider, comparison unit, oscillator, acoustic radiator, controllable current source, stable constant voltage source, perspiration equivalent unit, key member, illumination source, conductivity transducer having two electrodes, the first commutator, delay unit, trigger, inverter, discharge unit, the second commutator and feeding voltage availability indicator unit. The first delay unit inputs and the first commutator inputs are connected to comparison unit output. The first commutator input is connected to the first oscillator input which delay unit, trigger and inverter are connected in series. Inverter output is connected to the second input of the first and the second commutator. The first input of the second commutator is connected to the other conductivity transducer electrode and its output is connected to device body via resistor.
EFFECT: reduced current intensity passing through patient skin; excluded negative influence upon skin during prolonged operation time on patient arm during hypoglycemia attack; low power consumption.
2 cl, 4 dwg