Ichthyosin preparation

FIELD: medicine.

SUBSTANCE: invention can be used for the local treatment of trophic ulcers, infected and persistent septic wounds, degrees I-II-IIIA burns, traumatic skin injuries, pyoinflammatory skin diseases, bed sores, etc. The invention refers to a preparation, which contains a streptocide powder 1-2.5 g, Ichthyol ointment 7-10 g and castol oil 87.5-92 ml.

EFFECT: reducing the length of treatment up to 14 days with no side effects.

4 ex

 

The invention relates to the field of medicine, namely to medicines used for the local treatment of trophic ulcers, nonhealing infected and purulent wounds, burns I-II-IIIA degree of skin damage due to injury, chronic inflammatory diseases of the skin, bedsores, etc.

According to the literature in medical practice knows lots of different drugs used in the form of drugs in ointment form, possessing anti-inflammatory, ranozazhivlyayuschim and analgesic properties used for treatment of various pathological processes.

All known drugs differ in chemical structure, mechanism of action and pharmacological activity.

Widespread at the moment medicines in the form of solutions, suspensions and ointments, main ingredients, which are obtained by chemical synthesis.

Analogs of the invention

Known following tools and materials:

1) Ichthyol or ichthammol - ammonium salt of sulfonic acid shale oil contains 10.5% of organically bound sulfur has anti-inflammatory, local anesthetic and mild antiseptic properties. Primeneniya in the form of a 5-20% ointment for skin diseases (burns, erysipelas, eczema), etc. Moszkowski, M. D. "drugs". - 5-e Izd., Rev., Rev. and extra - M., 2007. - S. 955;

2) streptocidal ointment 10% or liniment of streptocid 5% is used for healing of infected wounds, burns I-II degree, chronic inflammatory skin diseases. Moszkowski, M. D. "drugs". - 15th ed., Rev., Rev. and extra - M., 2007. - S. 825;

3) levosin - ointment, 100 g, which contains the chloramphenicol 1 g, sulfadimetoksin methyluracil and 4 g of trimecaine 3 g of polyethylene oxide 88 g, which has antimicrobial, anti-inflammatory and analgesic effects and is used for the treatment of purulent wounds. Moszkowski, M. D. "drugs". - 15th ed., Rev., Rev. and extra - M., 2007. - S. 815;

4) levomekol ointment, 100 g, which contains chloramphenicol 0.75 g, methyluracil 4 g of polyethylene glycol 95,25 g, has antimicrobial, anti-inflammatory effect. Used for the treatment of purulent wounds. Moszkowski, M. D. "drugs". - 15th ed., Rev., Rev. and extra - M., 2007. - S. 815;

5) liniment (emulsion) of Chloromycetin, which contains 1%, 5% and 10% of Chloromycetin, castor oil, special emulsifier, distilled water, preservative. Used for the treatment of purulent wounds, inflammatory skin diseases, burns II-III degree. Moszkowski, M. D. "drugs". - 15th ed., Rev., Rev. and extra - M., 2007. - S. 817.

Criticism analogues

Disadvantages vysheperechislennyh�x drugs should recognize the following.

1. Insufficient efficiency their, used as drugs possess weak anti-inflammatory, local anesthetic and antiseptic properties.

2. Can experience allergic reactions and other side effects.

3. Many drugs have a number of contraindications and often not recommended for use due to the possible occurrence of complications.

4. Applying ointments has limitations, because their activity is manifested in different ways in relation to certain diseases.

5. In their application marked dermatitis, skin rash, itching and irritation of the skin around the wound.

6. Contraindications: in cases of psoriasis, eczema, fungal infections of the skin, depression of hematopoiesis.

7. Suppresses the local immune system some drugs that are included in the ointment.

The prototype of the invention

As the closest prototype to the present invention is balsamic liniment of A.V. Vishnevsky. Moszkowski, M. D. "drugs". - 15th ed., Rev., Rev. and extra - M., 2007. - S. 955.

Criticism prototype

The essence of the prototype

A. V. Vishnevsky ointment containing tar and xeroform 3 parts, 5 parts of Aerosil, castor oil 89 parts, has antiseptic, regenerative and mildly irritating. Used to treat wounds, ulcers, bedsores, burns.

One�about this ointment in the treatment process noted the following disadvantages.

The ointment has quite a pronounced therapeutic effect.

- Possible local irritating effect expressed in the reddening of the skin or lung irritation, burning sensation.

- Not effective enough, because it has weak anti-inflammatory, local anesthetic and antiseptic properties.

- Cannot fully provide everything necessary for the regeneration conditions, such as: balanced moist environment, activation of angiogenesis, the ability to accelerate the formation of collagen fibers, granulation and cell migration of epithelium.

- Not sufficiently effective in removing excess exudate, maintain humidity and provide gas exchange.

The purpose of the invention

The aim of the invention is to provide a simple, affordable, cheap and effective tool with a wide range of applications. However, he should be deprived of negative side effects, and the use must not have contraindications should be accessible and easy to use.

The essence of the invention consists in that the product contains components known in the pharmacology of drugs that are used in everyday medical practice and the receipt of public pharmacies. As components of medicinal products used: castor oil of 94.5 to 87.5 ml, poro�OK streptocid 0.5-2.5 g, ointment Ichthyol 5,0-10,0 m.

The method is implemented as follows. Pre-evaluate General and local clinical criteria of the patient, the stage of wound process, the timing of the cleansing of wounds, the appearance of granulation tissue and their activity, bacteriological, cytological, planimetric indices, etc.

The proposed tool, named "Ichthyosis" used in clinic for the local treatment of trophic ulcers, nonhealing infected and purulent wounds, burns I-II-IIIA degree of skin damage due to injury, chronic inflammatory diseases of the skin, bedsores, etc. for the first time. It is an oil composition, prigotovlyaemye ex tempore according to the following recipe: in an enamel Cup pour 94,5 to 87.5 ml of castor oil, there lay 5,0-10,0 g Ichthyol ointment and pour 0.5-2.5 g of sulfanilamide powder, stir them with a spatula. Then the Cup with the medicine the Foundation we put in a water bath at a temperature of 60-70°C, continue to carefully stir the mixture until it becomes a liquid that has dissolved all incoming medicinal components. Remove from the water bath, pour in disinfezione glass jar with lid. The period of storage of 6 months or more in a cool dark place. The resulting product is used in inpatient and outpatient practice.

Before each overlay means p�Voditsa toilet of the wound under aseptic conditions using a 3-1,5% hydrogen peroxide.

Above shows the composition of the funds is specified with min and max values of components used in the product.

This optimum ratio has been found in numerous experiments and confirmed in clinical observations.

All are included in the product components are allowed to use MOH. Moszkowski, M. D. "drugs". - 15th ed., Rev., Rev. and extra - M., 2007. - 1206 S.

Separate application components for the treatment of venous ulcers, nonhealing infected and purulent wounds, burns I-II-IIIA degree of skin damage due to injury, chronic inflammatory diseases of the skin, bedsores, etc. are ineffective. When using them in conjunction pronounced clinical effect, which can be explained by the synergies of their actions.

In the first (partially) and the second phase of wound process, the mixture is used with necroticism, anti-inflammatory and regenerative purpose, the concentration of active ingredients in it maximum.

During the second and third phases of wound healing to stimulate regeneration, protection of the wound surface from secondary infection and epithelialization, and the concentration of the active ingredients in it is minimal.

The tool is prepared in advance prior to ligation, which lubricated with sterile gauze or swab with a spatula � then applied to the wound with a preliminary washing it with peroxide. The frequency of dressing once a day.

The indications for the use of this tool are trophic ulcers, nonhealing infected and purulent wounds, burns I-II-IIIA degree of skin damage due to injury, chronic inflammatory diseases of the skin, bedsores, etc. partly in the first, second and third phases of wound process. It is desirable to use it in combination with hypertonic solutions and antiseptics in the first phase of wound process.

The only contraindication is Allergy to components included in the mixture, which in our patients was not in any case. Used the tool even in patients with severe allergic dermatitis in the area of wound healing, microbial, fungal and eczematous dermatitis.

The use of the invention allows to obtain the following technical result.

The tool Ichthyosis" is an effective combination drug for the topical treatment of many diseases: venous ulcers, nonhealing infected and purulent wounds, burns I-II-IIIA degree of skin damage due to injury, chronic inflammatory diseases of the skin, bedsores, etc., requiring the removal of pain, inflammatory reaction and regeneration stimulator. The effectiveness of the product is ensured by choice of the components of its active part, � their number.

The treatment time in comparison with known drugs for the local treatment dramatically reduced and are only 14 days on the course. Thus there are no side effects, therefore it has expanded the patient population and patients.

When using this tool, there is a pronounced improvement of the General and local clinical status.

The tool can be used both for treatment and prophylaxis of purulent-inflammatory response to injury.

The proposed remedy "Ichthyosis" has passed approbation in polyclinic №6, Makhachkala, Geriatric center veterans Hospital MOH RD, Department of surgery veterans RMC MOH RD, the burns unit at RCH MOH RD.

Clinical study of the drug conducted in 145 patients. With all the indications noted a positive therapeutic effect. Negative side effects were not observed in any of the cases.

The technical result is achieved by the combined use of the components included in the tool Ichthyosis", which together allowed us to obtain a therapeutic drug having anti-inflammatory, analgesic and ranozazhivlyayuschim action that underpin the basis of its wide use in the treatment of many diseases. The authors found that a tool called Ichthyosis" content�it components in such amounts, which provide together using maximum a pronounced therapeutic effect, and used oil base contributes to the effective maintenance of an optimal environment for good wound healing.

Unlike the proposed funds from the prototype is that the product contains components known in the pharmacology of medications used in routine medical practice. As components of medicinal drugs used castor oil, sulfanilamide powder, ointment of Ichthyol and when combined with their use in the proposed combination are due to the synergy of their actions is pronounced clinical effect, which dramatically reduces the treatment time in comparison with known drugs for local treatment.

An example of a specific implementation method

The method proposed in the invention, used in the treatment of venous ulcers, nonhealing infected and purulent wounds, burns I-II-IIIA degree of skin damage due to injury, chronic inflammatory diseases of the skin, bedsores, etc. from 145 patients in the surgical Department of the hospital of the veterans RMC MOH RD, the burns unit at RCH MOH RD, doctor's surgery polyclinic №6 Makhachkala and Geriatric center veterans hospital MOH RD. With all the indications noted on�vitellinae therapeutic effect. Negative side effects were not observed in any of the cases.

Example 1: Patient..., 73, husband. Addressed with extensive purulent wound on the right foot to the lower leg area 05.03.2013 in the surgical Department of the hospital of the veterans RMC MOH RD. During the week daily after the patient toilet wound with 3% hydrogen peroxide solution was applied to a gauze pad with "Ichthyocenos". The dressing was changed once a day, in subsequent ligation performed after wound toilet 1.5% hydrogen peroxide solution through the day. Ligation was performed without pain oshushenii patient. After 12 days the wound healed. The patient was discharged to outpatient treatment. When re-examination within a month the wound healed fully tender scar.

Example 2: Patient T..., 62, pers. Appealed to the clinic with complaints of pain in the feet. The examination revealed severe cracking of the heel area, complicated by bleeding the heel area. Conducted wound toilet according to the established procedure with applying bandages with "Ichthyocenos". After 3 days the skin was softened, the pain disappeared, and bleeding, and after 8 hours from the time of treatment the wound healed completely and in the heel area formed healthy gentle soft elastic skin.

Example 3: the Patient..., 67 years, women. Admitted to the hospital 14.01.2012 G. diagnosed with vinogradska ulcer in the lower third of the PRA�Oh tibia anteromedial surface of size 112 cm 2dermatosclerosis and hyperpigmentation in the lower third of the right tibia. Conducted local treatment "Ichthyocenos" during the week. Daily sick after going to the toilet of the wound with 3% hydrogen peroxide solution was applied with a napkin "Ichthyocenos" and held the outer elastic compression. The dressing was changed once a day. In subsequent ligation performed after wound toilet 1.5% hydrogen peroxide solution through the day. Ligation was performed without pain. 12 days trophic ulcer healed. The patient was discharged to outpatient treatment on day 18 with almost completely sagusa ulcer. When re-examination within 6 months of trophic ulcer completely healed tender scar.

Example 4: Patient X..., 72 G., pers. Obratilas in the surgical Department of the hospital of the veterans RMC MOH RD 03.04.2012 G. with erysipelas in necrotic stage (large wound) on the right foot at the ankle on marineparents side with severe pain seroma, high fever. During the week daily sick after going to the toilet of the wound with 3% hydrogen peroxide on the wound, put a napkin with "Ichthyocenos". After the first dressing after 10-15 minutes the pain is much crisis, and on the 3rd ligation almost absent. The dressing was changed once a day, in subsequent ligation performed after �of walata wound 1.5% hydrogen peroxide solution through the day, ligation was performed without pain by the patient. After 12 days the wound healed. The patient was discharged to outpatient treatment. When re-examination within a month the wound healed fully tender scar.

Thus, as shown by the treatment tool Ichthyosis" has local anti-inflammatory action, promotes the resorption of inflammatory process, dermatosclerosis and hyperpigmentation, exhibits analgesic and ranozazivluschee action that, with the ease of use and the absence of side effects makes extensive use of the drug in outpatient and inpatient settings.

The features of the invention, distinct from the prototype

1. The tool Ichthyosis" has quite a pronounced therapeutic effect.

2. There is no local irritating action, itching, burning sensation of the skin and wounds.

3. The drug has a pronounced anti-inflammatory, local anesthetic, antiseptic and ranozazhivlyayuschim effect.

4. When using the proposed combination of drugs provides everything you need for the regeneration conditions (balanced moist environment, activation of angiogenesis, speeds up the formation of collagen fibers, granulation and cell migration of the epithelium).

5. Quite effective in protecting the wound surface, removal of huts�TKA exudate, maintain humidity, gas exchange, improve the blood supply to the tissues, stimulate the regeneration of the epidermis, enhancing the processes of keratinization, temperature control, elimination of hypoxia and atraumatically.

The positive effect of the application of the invention

The proposed tool unlike other currently known drugs can improve the results of treatment of patients with trophic ulcers, infected and nonhealing purulent wound, burns I-II-IIIA degree of skin damage due to injury, chronic inflammatory diseases of the skin, bedsores, etc. Obtained rezultti from the use of this tool can accelerate at 1.5-2 times the wound cleansing from necrotic process; to ensure the rapid elimination of pathogenic microflora due to the bactericidal action of the drug; to intensify the processes of wound healing by stimulating regeneration raznodejstvujushchih agents; to reduce the degree of scar-sclerotic changes in paravasal tissues and to provide optimal conditions for the mechanism of wound contraction due to the ingredients included in the preparation.

Reduction of terms of treatment of patients, the cheapness of the drug and ease of use in all conditions, also favorably affects the economic effect, which helps improve� the quality of treatment for these patients.

Drug for treatment of purulent wounds and trophic ulcers, antiseptic preparations containing and oil-based, characterized in that it consists of medicines:

streptocid powderof 1.0-2.5 g
Ichthyol ointment7,0-10,0 g
castor oil87,5 is 92.0 ml



 

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