Method of treating periodontitis

FIELD: medicine.

SUBSTANCE: treatment is two-staged; at the first stage, gingival pockets are rinsed with a stream of 1.5% hydrogen peroxide in a cannula delivered through the gingival pockets around the teeth. If observing the exposed furcation of premolars and molars, the cannula is brought under the root furcation. Thereafter, the gingival pockets are similarly rinsed with an aqueous tincture of garden sage herb for 3-5 days, then with an aqueous tincture of camomile blossom for 3-5 days, an aqueous tincture of plantain leaves daily for the following 3-5 days; each rinsing procedure is followed by applications of cotton drains impregnated with the respective aqueous herbal tincture introduced by the cannula on gingival mucous membranes for 1 hour; that is combined with prescribing oral baths with the respective aqueous herbal tincture introduced by the cannula daily 5-7 times a day. The second stage involves instillations of Normoflorin-B or Bifidumbacterin in the cannula delivered through the gingival pockets around the teeth, brought under the furcation if observing the exposed furcation of premolars and molars; the gingival mucous membranes are laid with cotton drains with the above preparation for 2 hours daily for 5-10 days.

EFFECT: method enables providing the higher clinical effectiveness.

2 cl, 1 ex

 

The invention relates to medicine, in particular to dentistry, and can be used for the treatment of periodontitis.

A composition for the prevention and treatment of oral diseases and care of teeth and oral cavity, containing grass, chamomile, grass Hypericum perforatum, herb cottonweed swamp, herb of Echinacea purpurea, the leaves of sage, oak bark, calamus rhizome at a certain ratio of components. This composition is used as follows. 5 grams of powdered composition pour boiling water (250 ml) and extracted with during 15 minutes, filtered hot. Drink the water extract teeth and rinsing the mouth with warm water after meals and especially at bedtime after brushing your teeth. The composition, showing the effect on the capillaries, tissue, pathogen, stimulates the immune system, exhibits high anti-inflammatory, wound-healing and antimicrobial properties, no irritant effect [patent RU 2180555, 2002].

Known method of treatment and prevention of periodontal disease and the mucous membranes of the oral cavity, characterized by the fact that patients rinse the mouth 3-4 times a day obtained a solution of 15 ml of 70% alcohol tincture of herbal collection and 125 ml of water. The ratio of raw alcohol in the preparation of alcoholic astonishedly 1:5. In this case, the component ratio of raw materials, wt.h. is: the flowers of calendula drug - 1,0, grass Campion drooping or Tatar - 1,0, peppermint leaves and 0.2, the fruits of coriander sativum and 0.2. The method provides effective treatment due to the clear, reparative, healing, anti-inflammatory, analgesic, antiseptic, antimicrobial and antispasmodic action in the absence of irritating effects on the oral tissues [patent RU 2303455, 2007].

The known method of treatment of periodontitis, namely that carried out the preparatory phase of treatment, including medication. In addition, since the first day of treatment, is introduced into the liquid of synbiotic Normalien®-D inside 20 ml morning and evening for 20-30 minutes before meals for 30 days. Since the second week of treatment, in each periodontal pocket this synbiotic is administered in a dose of 0.2 ml daily, once, 5 procedures, and impose nedeshevye application synbiotic in the area of each tooth for 10 minutes under the same scheme [patent RU 2400243, 2010].

The known method of treatment of generalized periodontitis, including curettage of periodontal pockets and their antiseptic treatment, topically, a treatment of "Forest balsam" - application on the area of inflammation in an amount of 0.05-0.2 grams and an introduction to parodontal�e pockets. Treatment time of 15 minutes twice a day, a course of treatment 5-6 days; as a General treatment prescribed the drug "Gencom" on the capsule three times a day, treatment course of 5 weeks. The method allows to provide a high therapeutic effect by blockade of pathogens, improvement of regional hemodynamics gums, wound healing and epithelizing action, reduce perivascular edema and improve the metabolic processes in the blood vessels in the absence of unpleasant sensations in the patient [patent RU 2480228, 27.04.2013].

A method of treating periodontitis and inflammatory diseases of the mucous membranes of the oral cavity by use of a medicinal product in the form of a gel of the following composition, wt.%: oil fir 0,1-0,3, sage oil is 0.1-0.2, peppermint oil 0.1 to 0.3, glycerin 14,0-20,0, sodium alginate 4,0-5,0, pectin 2,5-4,0, polyvinylpyrrolidone 2,0-3,0, lidocaine hydrochloride 1,7-2,5, dimexide 0.5 to 1.0, the silver ions 0,001-0,004, methylene blue 0.01 to 0.02, purified water to 100. In chronic periodontitis mild medication applied to the area of inflammation in the amount of 0.05-0.2 g with an interval of 1 day a course of 4-6 sessions. When periodontitis of moderate severity of the drug applied to the region of inflammation in the amount of 0.05-0.2 g and injected it directly into each periodontal pocket 0,005 g for 4-6 days. The method provides a high therapeutic effect in no�Wii discomfort the patient [patent RU 2482859, 27.05.2013].

The closest analogue of the invention is a method for the treatment of periodontitis, namely that carried out the removal of supra - and subgingival hard and soft dental deposits, removal of granulation tissue, oral hygiene, professional dental cleaning, and then in periodontal pockets impose a 1.5% solution of hydrogen peroxide jet cannula, through the cannula for periodontal pockets around the teeth, when the exposure of Forcarei premolars and molars into the cannula under the furcation. 20 minutes after washing in periodontal pockets around the teeth for 2 hours, insert a cotton wick with the medication of bifidobacteria. The course of treatment is 5 to 20 procedures. It helps to remove inflammation when deep cleaning of periodontal pockets without unwanted gingival retraction due to the natural stimulation of the immune system, substitution of pathological obligately-anaerobic microflora on obligately-anaerobic normal, rapid regeneration of the mucosa while decreasing drug loading [patent RU 2470647, 2012]. The disadvantage of this method are its complexity in cooking and pasted turund, no analgesic, anti-inflammatory, strengthens the mucous membranes of therapeutic action, in addition, patients are not able to remove all the pockets with hard-to-reach places that will be an additional breeding ground for pathologies�Oh microflora.

The technical result when using the invention - improving therapeutic effect due to the introduction in treated periodontal pockets around the tooth herbal infusions, providing multifaceted therapeutic effect: pathogenetic effects on inflamed periodontal tissues (antiseptic, disinfectant, anti-inflammatory), improvement of metabolic processes in periodontal tissues at the histological and cellular levels, improvement of microcirculation and hemodynamics, trophic periodontal, stimulation of regeneration in the absence of unpleasant sensations in the patient.

Said technical result is achieved in that in the method of treating periodontal disease, including oral hygiene, removal of supra - and subgingival dental plaque, removal of granulation, a professional dental cleaning, irrigation of periodontal pockets 1.5% solution of hydrogen peroxide jet cannula, through the cannula for periodontal pockets around the teeth, and when exposure of Forcarei premolars and molars - into the cannula under the furcation, and the introduction of the drug, the bifidus bacteria in periodontal pockets according to the invention the treatment is carried out in two stages, moreover, in the first stage of periodontal pockets additionally washed in a similar way the water extract of herbs sage daily for 3-5 days, then water us�OEM chamomile flowers daily for 3-5 days then the water extract of plantain leaves daily for the next 3-5 days, after each washing is carried out the application of the mucous membranes of the gums with a cotton turundas with the corresponding cannula entered the water extract of herbs exposition of 1 hour, in addition, prescribe appropriate oral baths administered cannula aqueous infusion of herbs daily 5-7 times a day, and then at the second stage drug. Containing bifidobacteria administered the installation of the cannula, through the cannula for periodontal pockets around the teeth, when the exposure of Forcarei premolars and molars - into the cannula under the furcation, at the same time impose the mucous membrane of the gums with a cotton turundas with this drug exposure 2 hours daily for 5-10 days, as a preparation containing bifidobacteria, use Normalien-or Br.

The proposed method of treatment of periodontitis is as follows. After rehabilitation of the oral cavity, removal of above - and subgingival dental plaque, removal of granulation tissue, of teeth cleaning treatment is carried out in two stages. Thus at the first stage of periodontal pockets (PC) after washing with 1.5% hydrogen peroxide solution inkjet cannula, through the cannula for periodontal pockets around the teeth, and when exposure of Forcarei premolars and molars - for�Odom cannula under the furcation to exposure to pathogens daily injected water infusion of herbs sage in 3-5 days then within 3-5 days daily injected water infusion of chamomile flowers, in the next 3-5 days daily injected water infusion of plantain leaves, and grass infusions bolus injected with a cannula (a cannula for the introduction of gel to etch dentin and enamel (disposable nozzle for syringe with pickling gel) through the cannula for periodontal pockets around the teeth, and when exposure of Forcarei premolars and molars - into the cannula under the furcation after each washing is carried out the application of the mucous membranes of the gums with a cotton turundas with the corresponding cannula entered the water extract of herbs exposure 1 hour at the same time prescribe oral baths corresponding input cannula aqueous infusion of herbs 5-7 times a day. After that, the second step of the administered preparation containing bifidobacteria (Normalien-or Br), daily for 5-10 days, and conduct installation of bifidobacteria cannula, through the cannula for periodontal pockets around the teeth, when the exposure of Forcarei premolars and molars - into the cannula under the furcation, at the same time impose the mucous membrane of the gums with a cotton turundas with this drug, which leave in the form of applications to 2 hours.

After a deep wash PC hydrogen peroxide, ensuring their full mechanical antiseptic wipe, desi�viceroyship, antiseptic, deodorizing and hemostatic and stimulating blood flow to the effects, tissue oxygenation having oxidation-reduction capability, and guarantees the minimal trauma of the procedure, therapeutic effect of infusions of herbs inside the PC around the tooth allows the improvement of metabolic processes in the periodontal tissues at the histological and cellular levels, improve blood circulation, trophic periodontal, stimulation of regeneration, sustained remission.

Medicinal plants compared to synthetic drugs are much less toxic, have less side effects, less likely to cause allergies. Medicinal plants are weaker and softer, but the effect of their use more sustainable, easier digested and tolerated by the body (people are genetically predisposed for the period of centuries-old herbal treatments, including periodontal disease), have a wide therapeutic range and variety of therapeutic effects due to the content of biologically active and nutrients, and probiotics, bacteria of natural origin, in addition to restoring the natural microbial balance, have bacteriostatic and immunomodulatory effects.

In the proposed method uses three herbs, no congestion herbs, each herb ISP�box yourself, which ensures that no antagonistic effects on the body, the mucous membranes of the oral cavity.

The increase in therapeutic effect is achieved through:

1. Disinfectant, antiseptic, vasoconstrictor action (Salvia officinalis).

2. Painkillers that reduce inflammation (Matricaria recutita).

3. Promotes epithelialization and normalize the activity of the epithelium, ciliated epithelium of the mucous membrane of the oral cavity (plantain).

4. Colonization of the mucosa of the oral cavity and PC normal microflora (bifidobacteria).

Irrigation of periodontal pockets herbal infusion provides mechanical antiseptic, disinfectant, antifungal and antiseptic cleansing that can replace the use of industrial antiseptics. Often used as a symptomatic remedy non-steroidal anti-inflammatory drugs successfully replaced with analgesic and antipyretic actions esters and acetylsalicylic acid of natural origin, the negative effect disappears antacid properties of the infusions of chamomile and plantain. Secretolytic effects used herbal potions regulates the function of glands, alter the chemical composition of the gingival and oral fluid, dilute it, contribute to high�of work ciliated epithelium, reinforcing the effect of washing, restoring the function of the epithelium. Achieved a cumulative effect from tanning, vasoconstrictor, anti-inflammatory, antitoxic, strengthen the vascular wall effects infusions, the effect on the chemical composition of the gingival and oral fluids lacto - and bifidobacteria reduces the concentration of inflammatory mediators. In addition, antioxidant activity, anti-hypoxic effect of infusions of herbs and normoflorins important in the deterioration of blood supply to the mucosa.

Used the infusion of sage has antibacterial effect, which is caused by fitonzida salvino. Salvine not only hinders the reproduction of Staphylococcus aureus, but inactivates its α-toxin, inhibits its hemolytic and dermatopathies properties, inhibits the growth of fungi, protozoa, the tubercle Bacillus, inactivates viruses. Anti-inflammatory properties associated with tannins, flavonoid compounds and vitamin P, which have a vasoconstrictor action, compacted epithelial tissue, reduce the permeability of cell membranes and walls of blood and lymphatic vessels at the expense of acetylsalicylic acid due to wagamama property on the gums forms a protective sheath that prevents the penetration of the microbial flora of the wound surface�ness.

Infusion of chamomile has anti-inflammatory, styptic, disinfectant, antiseptic, mild astringent, analgesic, anti-allergic, sedative effect. Glycosides chamomile have mild atropine-like action, relax the smooth muscles, eliminating swelling of the mucous. Chamazulene and azulen enhance regenerative processes that weaken allergic reactions, have a local anesthetic action.

The active substance of plantain inhibit the growth of pathogenic microflora, have a sedative, hypotensive, anti-allergic effect. Hemostatic properties of the factor T, which improves blood clotting. The effect of tanning accelerates epithelization, vasostimulant granulation and prevents petechial bleeding maseribane surface. The instillation of an aqueous solution containing bifidus bacteria, prevents the growth of another pathological and saprophytic microflora. In addition, lacto - and bifidobacteria can affect various parts of the immune system, regulating nonspecific and specific cellular and humoral immunity that ensures the effectiveness of treatment in inflammation. Through the allocation of lacto - and bifidobacteria lactic acid suppressed the growth of microbial pathogens,� the number of conditionally pathogenic. Provide quick replacement of pathological microflora normal, create a protective biofilm on the mucosa, protecting it from viruses, bacteria, fungi, protozoa, save the presence of the colonizing potential, stimulate phagocytic activity of neutrophils, macrophages, synthesis of immunoglobulin A and are involved in the formation of interferons, is able to suppress the production of Ig E, then there is a natural immunomodulator and reduce sensitization.

Bifidobacteria help to increase your own lactoflora to normal. Infusions of herbs have a stimulating effect on the biological activity of lactic acid bacteria, increasing specific, antagonistic, adhesive, lactobacilius activity, antibiotic resistance and resistance to gingival and oral fluid. Products of metabolism of flavonoids Lactobacillus possess high antibacterial and fungistatic activity, and the use of lactobacilli in the oral cavity in the form of applications may result in multiple tooth decay, formation of biofilms on tooth enamel.

Bacteria Normoflorins L and B are biologically active, start working from the first minute of contact with the mucosa, the product of domestic production, antagonistically active against conventionally-p�togendai, pathogenic flora of our region.

The method of treatment is the prevention of diseases of the mucosa of the mouth, partial or fully edentulous, diseases of the gastrointestinal tract, respiratory system, urogenital system, etc.

This method treated 52 patients. In all cases was achieved the specified technical result.

The present invention is illustrated by the following example. Patient R., born in 1973, upon receipt of complaints of bad breath, bleeding when brushing your teeth, pain when you bite and the food. Objectively: mucous gums are hyperemic, swollen, bleeding when probing, periodontal pockets are defined by the depth of 4 mm. the teeth supragingival and subgingival hard and soft plaque. Specific breath. Diagnosis: chronic generalized periodontitis of moderate severity.

Was treated: after eliminating iatrogenic causes of periodontitis, sanation of the oral cavity, removal of above - and subgingival dental plaque, removal of granulation tissue, of teeth cleaning treatment was performed in two stages. Thus at the first stage of periodontal pockets after washing with 1.5% hydrogen peroxide solution inkjet cannula, through the cannula for periodontal pockets around the teeth, for exposure to pathogens daily injected water infusion of herbs sage of medicines�tively within 5 days then for 3 days daily injected water infusion of chamomile flowers, in the next 3 days were injected daily water infusion of plantain leaves, and grass infusions were injected jet cannula, through the cannula for periodontal pockets around the teeth, after each rinse was performed the application of the mucous membranes of the gums with a cotton turundas with the corresponding cannula entered the water extract of herbs exposure 1 hour. At the same time the house has appointed oral baths corresponding input cannula aqueous infusion of herbs 5-7 times a day. After this second stage was introduced Normalien-daily for 7 days, and underwent instillation of the drug, a cannula, through the cannula for periodontal pockets around the teeth, at the same time covered with the mucous membrane of the gums with this drug with a cotton turundas, which was left in the form of applications for 2 hours. Appointment of the mineral polivitaminov complex. After treatment objectively: the mucous membrane of the gums are pale pink in color, firmly attached to the tooth surface, PC decreased with depth up to 1.5-2 mm, dental plaque no, there is no specific breath. Hygienic index by Fedorov-volodkina good. When viewed through 6 months, 1 year recurrence of periodontitis was observed.

1. A method for the treatment of periodontitis, including refurbishment of the bands�and mouth, removal of supra - and subgingival dental plaque, removal of granulation, a professional dental cleaning, irrigation of periodontal pockets 1.5% solution of hydrogen peroxide jet cannula, through the cannula for periodontal pockets around the teeth, and when exposure of Forcarei premolars and molars - into the cannula under the furcation, and the introduction of a preparation containing bifidobacteria, in periodontal pockets, characterized in that the treatment is carried out in two phases, with the first stage of periodontal pockets additionally washed in a similar way the water extract of herbs sage daily for 3-5 days then the water extract of chamomile flowers daily for 3-5 days, after which the water extract of plantain leaves daily for the next 3-5 days, after each washing is carried out the application of the mucous membranes of the gums with a cotton turundas with the corresponding cannula entered the water extract of herbs exposition of 1 hour, in addition, prescribe appropriate oral baths administered cannula aqueous infusion of herbs daily 5-7 times a day, and then at the second stage, the preparation containing bifidobacteria, is administered by instillation of the cannula, through the cannula for periodontal pockets around the teeth, when the exposure of Forcarei premolars and molars - into the cannula under the furcation, at the same time impose �lesistye membrane of the gums with a cotton turundas with this drug exposure 2 hours daily for 5-10 days.

2. A method according to claim 1, comprising administering to the quality of the preparation containing bifidobacteria, Normoflorin-In or Bifidumbacterin.



 

Same patents:

FIELD: medicine.

SUBSTANCE: at the first stage, after removing supra- and sub-gingival dental calculus and granulations, cleaning the teeth professionally, rinsing gingival pockets by stream infusions of 1.5% hydrogen peroxide in a cannula delivered through the gingival pockets around the teeth, brought under root furcation if observing the exposed furcation of premolars and molars; the preparation "Calsept" is administered within the frontal teeth for 5-7 days daily into the gingival pockets bringing the cannula similarly around the teeth, whereas the preparation "Calsept-Iodo" is administered within the distal teeth; the dentist recommends that the patient does not eat for 2 hours thereafter. The second stage involves administering a preparation containing bifidus bacteria, e.g. Normoflorin-B or Bifidumbacterin by instillations in a cannula delivered through the gingival pockets around the teeth, brought under the furcation if observing the exposed furcation of premolars and molars; gingival mucous membranes are laid with cotton drains with the preparation for 2 hours daily for 5-10 days.

EFFECT: using the method provides increasing the therapeutic effect ensured by the antibacterial effect, odontotropic and anaesthetic action, bone tissue recovery, action of the therapeutic preparation in difficult-to-access anatomic formations.

2 cl, 1 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to health-promoting compositions and methods for preparing them. A method for preparing the composition of non-living lactic acid bacilli, possessing an ability of specific binding to Streptococcus mutans, involves the following stages: heating a cell suspension of lactic acid bacillus or a mixture of lactic acid bacilli possessing an ability of specific binding to Streptococcus mutans from an initial temperature of less than 40°C to a pasteurisation temperature of 75 to 85°C with a temperature variation within the range of 0.5 to 2°C/min, keeping the heated suspension at a pasteurisation temperature of 20 to 40 minutes and cooling the suspension to a final temperature of less than 40°C within the range of 0.5 to 2°C/min. The specific binding the cell suspension of the lactic acid bacillus or the mixture of lactic acid bacilli to Streptococcus mutans is stable to heat treatment and/or resistant to proteases and/or calcium-dependent and/or is observed within the range of pH values falling within the range of 4.5 and 8.5, and/or in the saliva environment.

EFFECT: invention enables producing the agent preventing or delaying the caries lesion formation.

9 cl, 4 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: group of inventions refers to oral care compositions containing a basic amino acid or its salt. The presented oral care composition promoting the dentine defect closure in the oral cavity contains arginine in the free form or in the form of a salt, and an abrasive substance representing synthetic amorphous silica and containing small particle fractures making at least approximately 5% of total weight of the composition, wherein the particles of the small particle fracture having d50 from 3 to 4 mcm. What is also presented is a method of treating sensitive teeth in the oral cavity involving using the oral treatment with this composition, as well as using arginine as a part of the oral care composition and for producing a therapeutic agent, wherein the above composition and agent contain the above abrasive material containing the small particle fracture.

EFFECT: group of inventions provide the effective dentin defect closure in the patient's oral cavity.

8 cl, 1 tbl, 6 ex

FIELD: medicine.

SUBSTANCE: carious cavity is prepared. Then it is treated instrumentally and antiseptically. A hole of an apical canal of a causative tooth is expanded. Methylene blue is introduced into the cyst through a root canal at a depth of 7-10 min. The cyst envelope is exposed to a laser light generated by a diode laser through the root canal for 30-60 s by means of a needle light guide. The exposure is continued from the vestibular or oral surface for 60.0-120.0 s by means of a plate light guide of intensity 0.5-1 W, wave length 625-630 nm in a pulse mode. Before the root canals of the causative tooth is hermetically sealed, Collap-An gel with metrogil 1.0-1.5 ml is introduced into the cyst.

EFFECT: method enables provides increasing clinical effectiveness, avoiding the complications by removing the cyst envelope completely that enables restoring the bone defect structure completely.

2 ex

FIELD: medicine.

SUBSTANCE: agent for local therapy of recurrent oral aphthae accompanying dental stomatitis and periodontitis contains glycerine, kalanchoe juice and common nettle juice, glucosamine hydrochloride and dimethylsulphoxide, lavender, common thyme, garden sage and pepper mint essences, lime blossom and drinking water in a certain ratio.

EFFECT: agent possesses anti-inflammatory, antibacterial, wound healing, haemostatic, local anaesthetic, saliva thinning properties enabling its effective use for combined periodontal and oral mucosal pathologies in the form of dental stomatitis and periodontitis, including if observing deep periodontal pockets.

3 ex

FIELD: medicine.

SUBSTANCE: first, the method involves teeth cleaning, surgical site isolation with cotton swabs, drug-induced treatment of 2% chlorhexidine and drying. Then, an erosion surface and adjoining solid dental tissues are coated with a phytoapipreparation for 15-20 minutes. The preparation is presented in the form of an ointment and has the following composition, weight fractions: 40% alcoholate (1:10) of tartarian catchfly or rhizomes and roots of maral root 10 ml, 40% alcoholate (1:10) of spirea herb 5 ml, apilac 0.5 g, clove ester 0.5 ml, lanolin 25.2 g, Vaselin 58.8 g. The ointment is used once a day for 10 days with the patients advised to avoid eating for one hour.

EFFECT: method is easy-to-use and physiological, and ensures an absolute recovery.

2 ex

FIELD: medicine.

SUBSTANCE: performing a dental intervention in the patients suffering an acute stroke requires the oral administration or injections of a broad-spectrum antibiotic after examining the mouth or determining the extent of the dental intervention extent 30-60 minutes before the expected intervention. The patient is placed in a dental chair in a reclining posture at an angle of 35-50 degrees; a blood pressure is measured, and if the measured systolic pressure is 135-145 mm Hg, the dental intervention is performed. The dental intervention involves blood pressure monitoring, while the conduction anaesthesia is performed with 3% mepivacaine in a combination with the infiltration anaesthesia with 4% articaine with epinephrine 1:200,000 in a quantitative ratio 3:1.

EFFECT: method enables reducing complications and minimising injuries of the dental interventions by using the smoothest possible technique thereof.

3 ex

FIELD: medicine.

SUBSTANCE: method involves performing the following stages: - treating a nerve canal with sodium hypochlorite in the concentration of 0.5-5.25 wt %, in an amount of 1-20 ml for one root canal and activating with ultrasound at frequency 20-40 kHz; both one-stage activation with ultrasound accompanying the treatment, and alternating the sodium hypochlorite treatment and activation with ultrasound every 3-5 sec are possible, - treating with ozonised normal saline in the ozone concentration of 10 mcg to 60 mg per one litre, in an amount of 1-20 ml per 1 root canal and activating with ultrasound at frequency 20-40 kHz, - treating with aqueous chlorhexidine in the concentration of 0.12-2 wt %, in an amount of 1-20 ml per one root canal and activating with ultrasound at frequency 20-40 kHz; the above stages are intermitted with time intervals of no more than 3 minutes, and each stage lasts for 3 to 15 minutes.

EFFECT: high quality of treatment by preventing a post-filling aggravation and reducing the length of periodontal tissue regeneration; the method is easy-to-implement and efficient.

2 ex

FIELD: medicine.

SUBSTANCE: method for the local treatment of oral lichen planus of typical shape consists in coating a lesion twice a day with two uniform layers no more than 0.01 mm thick of a therapeutic composition of tysol and lydase in ratio: tysol 10g, lydase 128 international units for 15 minutes. The therapeutic course makes 14 days.

EFFECT: using the method provides the optimum concentration of the therapeutic composition in the lesion for ensuring the high therapeutic effect with the preparations of tysol and lydase potentiating each other that enables preventing the advance or terminating the hyperkeratosis manifestations.

2 ex, 4 dwg

FIELD: medicine.

SUBSTANCE: method involves preparing a carious cavity, conducting a medically induced processing of the dental solid tissues and applying a therapeutic liner and stopping a permanent filling. The medically induced processing is conducted with the use of butol. Upon completion of the processing, the therapeutic liner of a mixture of zinc-sulphate cement with butol is applied.

EFFECT: adequate anti-inflammatory action and optimum diffusion of the therapeutic agent into the solid dental tissues by the uniform butol distribution in the specified cement, which leaves the antimicrobial effect of the preparation undistorted.

9 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to pharmaceutical industry, namely to a method for preparing lappaconitine hydrobromide (versions) A method for preparing lappaconitine hydrobromide is implemented by extraction of Aconitum leucostomum root and herb or Aconitum septentrionale root and herb in methylene chloride in a continuous extraction apparatus that is followed by decontamination by means of flash chromatography (version 1), or extraction of a herbal raw material in a polar organic solvent followed by extract removal from the organic solvent (version 2), alkalinisation and extraction of the prepared extract in methylene chloride followed by decontamination of the extract by flash chromatography.

EFFECT: method for preparing lappaconitine hydrobromide provides simplifying the technological process, reducing its length and improving higher yield of the end product of officinal purity.

7 cl, 1 tbl, 9 ex

FIELD: medicine.

SUBSTANCE: agent for treating diabetes mellitus involving dry aqueous extract of Geranium Dieisianium Knuth and dry aqueous extract of Uncaria tomentosa (Willd) D.C. bark enclosed into gelatine capsules. A method of treating diabetes mellitus provides prescribing the above agent in a daily dose of 180-360 mg after a meal. The above agent enables treating diabetes mellitus effectively by reducing dosages of blood glucose lowering drugs.

EFFECT: agent causes the positive effect on carbohydrate metabolism and possesses non-specific immunomodulatory action.

2 cl, 5 tbl

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to chemical-pharmaceutical industry and represents composition for oral cavity care, containing: a) at least one compound of formula M1-A-M2-B-M3, where: M1 and M3 represent Ti or titanium (Ti) oxide; A and B represent C2-C6 dibasic acid; and b) at least one orally acceptable solvent; where composition contains less than 5% of water.

EFFECT: invention provides creation of composition for treatment of teeth hypersensitivity, which effectively seals open dentin canals.

7 cl, 8 tbl, 12 dwg, 1 ex

FIELD: biotechnology.

SUBSTANCE: method comprises dissolving the mixture of birch bark triterpenoids in tetrahydrofuran to obtain the solution with a concentration of 5-10 g/l. Oleic acid is dissolved in an amount of 5-10% by weight of the birch bark triterpenoids. The sterilising filtration of the mixture is carried out. 25-fold excess of 0.01 M tris buffer is added, pH 9.0±0.2, when stirring. Sonication is carried out for 5-10 min. The organic solvent is removed using ultrafiltration on hollow membranes with exclusion threshold of 300 kDa at a rate of 1.0-1.2 L/min at a pressure of 0.6-0.8 atm. Cryoprotectant is added from the group of substances: mannitol, maltose, trehalose, mannose, sorbite, sucrose. The resulting concentrated mixture is frozen.

EFFECT: invention enhances the immunogenic activity of viral vaccines and provides their stability while storage.

2 cl, 2 dwg, 6 tbl, 7 ex

FIELD: medicine.

SUBSTANCE: group of inventions refers to an anti-ageing product. Moringa sp. whole seed extract for an anti-ageing effect containing oil and polyphenols representing an extract prepared of a moderately polar solvent. Using Moringa sp. whole seed extract as an active anti-ageing ingredient. Using Moringa sp. whole seed extract for enhancing and recovering a skin barrier function. A cosmetic and/or dermatologic anti-ageing composition. A cosmetic method for the anti-ageing effect in the individuals with mature skin, involving using topical or oral administration of Moringa sp. whole seed extract. A method for preparing Moringa sp. whole seed extract.

EFFECT: extract is effective for the anti-ageing effect.

12 cl, 1 tbl, 5 ex, 1 dwg

FIELD: food industry.

SUBSTANCE: method for production of Siberian cedar seeds liqueur (with hepatoprotective, antioxidant, antihypoxic, hypolipidemic effect) by way of maceration with ethyl alcohol usage; whole Siberian cedar seeds are loaded into the reactor, poured with 70% ethyl alcohol water solution; extraction is performed under preset conditions. The medicinal preparation with hepatoprotective, antioxidant, antihypoxic, hypolipidemic effect contains Siberian cedar seeds liqueur. Usage of the medicinal preparation as a hepatoprotective remedy.

EFFECT: liqueur has pronounced hepatoprotective, antioxidant, antihypoxic and hypolipidemic effect.

6 cl, 3 dwg, 8 tbl

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to cosmetology and dermatology and represents a skin care composition applicable for local skin application, wherein the above composition contains salicylic acid or its salt in a combination with glycyrrhizic acid, or its salt or its derivative, cetylhydroxyproline palmitamide, lactic acid or its salt, bisabolol and niacinamide.

EFFECT: invention provides extending the range of effective skin care agents.

41 cl, 11 ex, 11 tbl

FIELD: medicine, pharmaceutics.

SUBSTANCE: group of inventions concerns oral care compositions effective for treating dental hypersensitivity, and a method of treating using them. The composition contains a compound of formula I: M1-A-M2-B-M1; wherein M1 and M3 represent potassium (K); M2 represents Ti or titanium (Ti) oxide; A and B independently represent C2-C6 dibasic acid; and at least one orally acceptable solvent. The oral care composition has pH falling within the range of 2.0 to 7.0. There are also presented a version of the composition, which contains at least one additional desensitising agent, and a method of treating sensitive teeth with the use of this composition.

EFFECT: using the group of inventions provides the effective dental desensitisation by creating a protective barrier on the tooth surface and/or sealing the effective dental tubules effectively.

11 cl, 8 tbl, 12 dwg

FIELD: chemistry.

SUBSTANCE: invention relates to the field of organic chemistry, namely to novel pyridine derivatives of the general formula

and to their pharmaceutically acceptable salts, where R1 stands for (C1-6) alkyloxy, CN or halogen, R2 stands for a hydrogen atom, R3 stands for a hydrogen atom or (C1-6) alkyl, R4, R5, R6, R7 are similar or different and stand for a hydrogen atom or halogen. The invention also relates to the cosmetic application of the formula (I) compound.

EFFECT: novel pyridine derivatives, useful in the treatment of diseases associated with a receptor of androgens, are obtained.

9 cl, 1 tbl, 16 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to health-promoting compositions and methods for preparing them. A method for preparing the composition of non-living lactic acid bacilli, possessing an ability of specific binding to Streptococcus mutans, involves the following stages: heating a cell suspension of lactic acid bacillus or a mixture of lactic acid bacilli possessing an ability of specific binding to Streptococcus mutans from an initial temperature of less than 40°C to a pasteurisation temperature of 75 to 85°C with a temperature variation within the range of 0.5 to 2°C/min, keeping the heated suspension at a pasteurisation temperature of 20 to 40 minutes and cooling the suspension to a final temperature of less than 40°C within the range of 0.5 to 2°C/min. The specific binding the cell suspension of the lactic acid bacillus or the mixture of lactic acid bacilli to Streptococcus mutans is stable to heat treatment and/or resistant to proteases and/or calcium-dependent and/or is observed within the range of pH values falling within the range of 4.5 and 8.5, and/or in the saliva environment.

EFFECT: invention enables producing the agent preventing or delaying the caries lesion formation.

9 cl, 4 ex

FIELD: medicine.

SUBSTANCE: at the first stage, after removing supra- and sub-gingival dental calculus and granulations, cleaning the teeth professionally, rinsing gingival pockets by stream infusions of 1.5% hydrogen peroxide in a cannula delivered through the gingival pockets around the teeth, brought under root furcation if observing the exposed furcation of premolars and molars; the preparation "Calsept" is administered within the frontal teeth for 5-7 days daily into the gingival pockets bringing the cannula similarly around the teeth, whereas the preparation "Calsept-Iodo" is administered within the distal teeth; the dentist recommends that the patient does not eat for 2 hours thereafter. The second stage involves administering a preparation containing bifidus bacteria, e.g. Normoflorin-B or Bifidumbacterin by instillations in a cannula delivered through the gingival pockets around the teeth, brought under the furcation if observing the exposed furcation of premolars and molars; gingival mucous membranes are laid with cotton drains with the preparation for 2 hours daily for 5-10 days.

EFFECT: using the method provides increasing the therapeutic effect ensured by the antibacterial effect, odontotropic and anaesthetic action, bone tissue recovery, action of the therapeutic preparation in difficult-to-access anatomic formations.

2 cl, 1 ex

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