Method of treating bullous keratopathy
SUBSTANCE: invention refers to medicine, particularly to ophthalmopathy, and can be used in treating endothelial-epithelial corneal dystrophy. That is ensured by de-epithelisation, 12-o'clock corneal incision and splitting, administration of a biologically active substance into a stromal pocket of the cornea. The biologically active substance is poludan-activated autoplasma. Before the epithelisation is completed, a soft contact lens is placed on the cornea. The operation is followed by instillations of ciprofloxacin, diclofenac 6 times a day and infusions of cornegel.
EFFECT: method provides reducing the intraoperative injuries and the length of patients' treatment, including by local (intrastromal) autocytokinotherapy.
The invention relates to medicine, in particular to ophthalmology, and can be used in the treatment of endothelial-epithelial corneal dystrophy.
A method of treating eej corneal proposed Temirova N. E., The Tkacheva M. S. (Proc. Dokl. VII Congress of ophthalmologists of Russia. Moscow, 2000, p. 47), which consists in intralaminar keratopathy as a decongestant barrier polyacrylamide hydrogel.
The disadvantage of the proposed method are possible complications associated with damage to the descemet's membrane of high density polyacrylamide hydrogel, the development of secondary hypertension, recurrent bullous keratopathy.
The closest in technical essence is a method of treating bullous keratopathy proposed Gorban, A. I. et al. (Coll. nauch. Tr., 1989, p. 36-38), comprising vnutrirodovoe the introduction of autologous blood.
A disadvantage of the proposed method of treatment are possible complications associated with damage to the descemet membrane (rupture), the subsequent penetration of blood in the anterior chamber, lock the angle of the anterior chamber and pupillary area elements of the blood and the development of secondary glaucoma, relapse process ectasia of the cornea, the lack of efficiency associated with limited distribution autologous blood formed only on the channel neces�ü sutures to secure the edges of the cut.
The object of the invention is the reduction of surgical trauma surgery, reduction of terms of treatment of patients with endothelial-epithelial corneal dystrophy by local (intratumoral) autocatakinetic.
The invention consists in that in the method for the treatment of bullous keratopathy, including decapitalization, the incision of the cornea in a pre-selected Meridian, for example for 12 hours in 0.5 plasma of the patient, activated poludanom using the methodology described in 2001 Kasparov A. (Kasparov, A. A., Kasparov E. A., Pavlyuk, A. S. West. Ophthalmology, 2004, vol. 120, No. 1, p. 29).
The method of activation is as follows: from the vein of the patient into the test tube take 5,0-6,0 ml of autologous blood with subsequent mixing with 1.0 ml of a solution of paludina (200 units) in distilled water. Taken mixture is subjected to centrifugation and then take away from the tube into the syringe formed of the upper transparent layer of blood plasma in a volume of 1.5-2.5 ml.
Pronounced therapeutic effect, manifested in the relief of signs eej (corneal syndrome, the disappearance of the pericorneal injection, bullous changes, corneal edema corneal tissue and increasing transparency, improving visual acuity) is explained in more intensive production of interferons α, β and γ in response to the introduction of paludina in culture of blood cells (intras�romalee and subconjunctival depot), causing secretion cascade of complex cytokine with activity of interleukins 1, 2, 8, tumor necrosis factor, and growth factors, as well as proven antiapoptosis action Paludan in the culture of cells. The complex of cytokines contributed to the relief of inflammation and stimulate the regeneration of the corneal endothelium. This method allows a direct impact on the damaged structures of the cornea (Mityagin O. N., Pavlyuk A. S. Effect of immunomodulator "paludina" on cellular regeneration and condition of apoptosis in the experiment // Abstracts of the 1st Russian Symposium on refractive surgery M., 1999, p. 66).
Example 1. Patient D. was admitted to inpatient treatment in the ophthalmology Department of the Amur oblast clinical hospital with the diagnosis of Endothelial-epithelial corneal dystrophy article 3, posterior chamber pseudophakia the left eye. From history - operated in 2011 cataract surgery with implantation of a posterior chamber intraocular lens is 1 mm from the limbus, its peel, the introduction of 0.5-1.0 ml of biologically active substances in stromal corneal pocket, the introduction of an excess of autoplasma of 1.0-1.5 ml under the conjunctiva paralambano, areas on the cornea until complete epithelialization of soft contact lenses and innstillingane after surgery in the conjunctival cavity solution ciprof�oxazine 6 times a day, solution of diclofenac 6 times a day, laying corneregel 6 times a day for 14 days, as a biologically active substance is introduced into the stromal pocket of the cornea and conjunctiva paralambano use autoplasma, activated poludanom.
Introduction as a biologically active substance of autoplasma, activated poludanom, allows you to create depot in the "target organ" of the complex mediators of immunity - of cytokines with anti-inflammatory and stimulant properties (Kasparov, A. A., Kasparov E. A., Pavlyuk, A. S. West. Ophthalmology, 2004, vol. 120, No. 1, p. 29).
The method is as follows. After local epibulbar anesthesia, microspatial decapitalizing the entire surface of the cornea. In a pre-selected Meridian, for example for 12 hours in 0.5-1 mm from the limbus, an incision to a depth of 2/3 of the corneal stroma with a length of 2.0 mm. Then disposable rasseivatele split your cornea over the entire area to a depth of 2/3 of the stroma. Produce paracentesis in the area of the notches with the release of moisture anterior chamber to create hypotonia of the eye and to prevent return of the outpouring of the plasma. In a pocket formed with a syringe and cannula injected with 0.5-1.0 ml of autoplasma, activated poludanom. The excess of autoplasma of 1.0-1.5 ml injected under the conjunctiva paralambano. To complete epithelialization on �agovice placed a soft contact lens, additionally, after the operation in the conjunctival cavity deployed the solution ciprofloxacina 6 times a day, the solution of diclofenac 6 times a day, laid corneregel 6 times a day for 14 days. Used (IOL). After the operation eyesight has not improved, the patient appeared subjective feeling of a foreign body, photophobia, watery eyes in the operated eye. Was repeatedly hospitalized for inpatient treatment. Improvement in the operated eye was kept on a short period of time and every exacerbation of the inflammatory process leading to decreased function of the eye, as well as the growth of corneal syndrome - photophobia, watery eyes, feeling of a foreign body in the eye. The patient was offered an operation of intrastromal certaintie of autoplasma, activated poludanom by the above proposed method. After surgery, the patient is assigned instaliranje in the conjunctival cavity solution ciprofloxacina 6 times a day, of a solution of diclofenac 6 times a day, the laying of corneregel 6 times a day for 14 days. The state of the left eye before surgery - mixed injection, expressed blepharospasm, photophobia, lacrimation. Bullous edema of the epithelium with erosion, diffuse swelling of all layers of the cornea. Front camera is of medium depth, the pupil is irregular, de�Ali and the position of the IOL is not visualized. The vision in the left eye - 0,01 not offset. The state of the left eye in the 1st day after surgery - eyes moderately annoyed, remains the corneal syndrome, biomicroscopic diffuse swelling of all layers of the cornea, in the deeper layers of the cornea, light yellow entered autoplasma, on the edge of the cornea restoration of the epithelial layer.
The state of the eye on the 8th day after the operation - at discharge. Gone are the complaints of pain, feeling of a foreign body in the eye. Eyes moderately annoyed, corneal syndrome is absent, completely restored the integrity of the epithelial layer in the layers of the cornea light yellow autoplasma. Increased transparency of the cornea. Visual acuity in the operated eye - 0,02 not offset.
The condition of the eye through 2 months after surgery - eyes calm, visual acuity in the range of 0.03 is not offset. Completely gone blepharospasm, photophobia and lacrimation. The superficial layers of the corneal epithelization and were transparent, noted the complete absence of bullous bubbles. In the optical zone of the cornea, in the deep layers is ill-defined opacity.
Example 2. Patient B. was admitted to inpatient treatment in the ophthalmology Department of the Amur oblast clinical hospital with the diagnosis of Endothelial-epithelial corneal dystrophy article 3, posterior chamber pseudophakia right eye. The visual acuity of the right - CQ�t of the fingers of a person. The state of the eye - the eye is irritated, expressed blepharospasm, photophobia, lacrimation. Extensive bullous bubbles with areas of erosion, swelling of all corneal layers, folds in descemet's membrane. Front camera is of medium depth, the pupil of the correct form, in pupillary area is viewed posterior chamber IOL. Patient V. produced by the operation of intrastromal certaintie of autoplasma, activated poludanom, according to the method described above. After surgery, the patient is assigned installation in the conjunctival cavity solution ciprofloxacina 6 times a day, of a solution of diclofenac 6 times a day, the laying of corneregel 6 times a day for 14 days. 24 hours after surgery, the patient's condition is satisfactory, the operated eyes moderately annoyed, swelling all layers of the cornea into the stromal layer is rendered introduced autoplasma. Front camera and the pupil area in detail not ophthalmoscopically. Within 5 days after the surgery the patient had no complaints. The operated eyes was almost calm, visual acuity 0,01 not offset. Slight swelling of all layers of the cornea, the epithelium is completely recovered. 1.5 months after surgery during the examination the patient had visual acuity of the operated eye within 0.02 not offset. The eye was completely calm, completely absent corneal syndrome.In the deeper layers was visualized fibrosis of the stroma.
Thus, the proposed method compared to known makes it possible to reduce the trauma due to the exclusion of stitches to secure the edges of the cut and to avoid possible complications in the postoperative period to reduce treatment time by creating a local depot of biologically active molecules (cytokines directly into the tissue of the cornea, which cropped inflammation, stimulates regeneration processes.
A method for the treatment of bullous keratopathy, including the execution of a corneal incision, the dissection of the cornea and the introduction of biologically active substances in stromal pocket, characterized in that you epitelizatia of the cornea, as a biologically active substance is introduced into the stromal pocket of the cornea and conjunctiva paralambano, use autoplasma, activated poludanom, and on the cornea until complete epithelialization placed a soft contact lens and install after surgery in the conjunctival cavity solution of ciprofloxacin 6 times a day, the solution of diclofenac 6 times a day and lay corneregel 6 times a day.
SUBSTANCE: treating postoperative corneal erosions following pterygium removal. That is ensured by postoperative instillations of drug preparations for corneal erosion. Additionally, the final stage of pterygium removal operation involves administering ozone-oxygen mixture in the concentration of 2 mg/l in an amount of 0.5 ml subconjunctivally. The injection is repeated in the same concentration and amount on the following postoperative day. The method increases the operation effectiveness by reducing postoperative complications and negative symptoms in the patient, including by a compensatory increase of antioxidant enzyme activity, reducing tissue and recovering metabolic processes in the involved tissues, reducing a probability of coarse cicatrisation in the operation region.
EFFECT: method is easy and accessible to implement.
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to a compound presented by formula , or their pharmaceutically acceptable salt, which can find application for treating or preventing ophthalmic diseases.
EFFECT: invention refers to the pharmaceutical compositions and methods of treating the ophthalmic diseases with the use of the above compound.
13 cl, 7 dwg, 7 tbl, 4 ex
SUBSTANCE: method involves corneal impregnation with 0.1% riboflavin and ultraviolet exposure at a wave length of 365-375 nm for 30 min. Before impregnation, the cornea is coated with 40% glucose kept on the corneal surface for 9-11 min; residual glucose is removed, and the glucose-treated corneal surface is coated with 0.1% riboflavin for 30 min.
EFFECT: eliminating postoperative complications, reducing the length of the patients' rehabilitation, and achieving the high functional results of the operation.
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to the pharmaceutical industry and represents an ophthalmic solution containing riboflavin and vitamin E for the UV-A rays protection of the internal structures of an eyeball and for treating keratoconus by transepithelial crosslinking.
EFFECT: invention provides extending the range of products for the UV-A rays protection of the internal structures of the eyeball and for treating keratoconus by transepithelial crosslinking.
9 cl, 10 dwg
SUBSTANCE: simulating this pathology is accompanied by pharmacological preconditioning. That is ensured by using Nicorandil in a single dose of 0.86 mg/kg of body weight which is introduced intragastrically through a probe in the form of a starch solution into a laboratory animal. Ischemia of the retina is simulated 30 minutes later by delivering mechanical pressure of 110 mm Hg on an anterior eye chamber for 30 minutes.
EFFECT: method provides the pronounced correction of ischemic ocular injuries.
1 ex, 1 tbl
SUBSTANCE: method involves simulating retinal pathology and preventing it by administering recombinant erythropoietin as a preconditioning agent into a laboratory animal. Erythropoietin is administered daily once on the first experimental day intragastrically in a dose of 50 IU/kg 30 minutes before simulating the pathology. The method promotes the pronounced correction of ischemia of the retina ensured by a mechanism of opening of ATP-dependent K+-canals followed by inducing mechanisms of metabolic adaptation in implementing the preconditioning effect.
EFFECT: preventing the ischemic conditions of the retina.
1 ex, 1 tbl
SUBSTANCE: invention refers to medicine, namely to ophthalmology and to devices for the intermittent active substance feed into a naso-lachrymal duct. The device comprises a tube inserted into a lachrymal opening plug cavity. The tube comprises hole, which is fluid-connected to a cavity formed in a tube body and comprising a drug. The device also comprises two or more linearly aligned dosage units for the intermittent feed inside the tube; two or more dosage units for the intermittent feed comprises a core containing the active substance, and a water-soluble encapsulating layer surrounding the core. A boundary layer between the first and second dosage unit for the intermittent feed is soluble in lachrymal fluid. A thickness and physical characteristics of the soluble boundary layer can be adjusted to control time intervals between the instants of the intermittent drug feed.
EFFECT: such implementation of the device provides the regulated intermittent feed with the controlled time intervals between the instants of the feed of one or more active substances, including in small amounts, into one or both naso-lachrymal ducts and into the lachrymal fluid through a plug in the lachrymal opening in the form of a linear sequence of feed pulses for delaying or preventing a disorder or a condition of one or more organs, namely eyes, a nose, or a throat.
16 cl, 11 dwg
SUBSTANCE: group of inventions refers to medicine, namely to ophthalmology, and aims at treating eye discomfort. Treating the eye discomfort is ensured by applying a liquid composition containing a cooling agent. The cooling agent represents 2,3-dihydroxypropyl ester of (1R,2S,5R)-2-isopropyl-5-methylcyclohexane carboxylic acid (or CPS-030). The liquid composition of the cooling agent is applied locally on at least a part of the outer surface of the eyelid (preferentially a closed one) to be treated. Preferentially, the liquid composition of the cooling agent is applied on a tissue, a tampon or a wipe or is enclosed into a tissue, a tampon or a wipe, e.g. an eye wipe.
EFFECT: using the group of inventions provides the prolonged relief of the eye discomfort with no eye irritation.
57 cl, 1 tbl, 1 dwg, 6 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to medicine, and concerns an ophthalmic composition for treating dry eye, which is presented in the form of a water-based liquid solution with its base containing rebamipide, meglumine and boric acid, and/or phosphoric acid, wherein the amount of the inorganic cation, different from hydronium ion in the ophthalmic composition is less than 15 mEq.
EFFECT: invention provides maintaining the transparency of the rebamipide-containing solution.
5 cl, 58 ex, 4 tbl
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to compounds of formula
wherein pyridine rings A, B and C are independently unsubstituted or substituted by one or more substitutes independently specified in a group consisting of: C1-6-alkyl, halogen alkyl having 1-6 carbon atoms, Hal or OR13; L1 and L2 are independently specified in residues having formula or , wherein at least one of L1 or L2 has formula (b); R1 and R2 are independently specified in a group consisting of hydrogen, C1-6-alkyl and phenyl; R3 is specified in hydrogen and C1-6-alkyl; R4, R5, R6 and R7 are independently specified in a group consisting of hydrogen and C1-6-alkyl; R8, R9, R10 and R11 are independently specified in a group consisting of hydrogen and C1-6-alkyl; R12 is specified in a group consisting of hydrogen and C1-6-alkyl; R13 is independently specified in a group consisting of hydrogen, C1-6-alkyl and phenyl; p is equal to 1 or 2; q is equal to 0, 1 or 2, and Hal is specified in a group consisting of F, Cl, Br, and I, which can be used in treating a group of amyloid protein related disturbances and disorders.
EFFECT: preparing the compounds which can be used in treating a group of amyloid protein related disturbances and disorders.
17 cl, 1 dwg, 6 tbl, 13 ex
SUBSTANCE: treating trophic ulcers is ensured by using autoserum prepared of blood 20.0-25.0 ml; centrifuging and separating it from a protein-thrombocyte clot are followed by edge chipping under a wound bed, while the protein-thrombocyte clot is used to be laid on the wound directly. The above procedures are repeated up to 20 times every two days.
EFFECT: invention enables providing fast wound healing with the adequate recovery of the dermal skin layer by using the high-biocompatibility material containing the ingredients creating the optimum medium for the wound regeneration.
SUBSTANCE: invention refers to medicine, namely to cardiovascular surgery, and concerns preventing a diffuse intra- and postoperative blood loss in surgery of abdominal aorta. To this effect, performing the aortoiliac operations is combined with measuring preoperative antithrombin III; if the measured value is less than 87±3%, a thromboelastography is performed from the moment of an anaesthetic support started with determining a coagulation index. If the coagulation index is less than 2.89±0.25 as early as at the start of the stage of approaching the abdominal aorta, before any surgically significant blood loss, fresh-frozen plasma of the identical group in a min. amount of 600 ml is administered into the patient. If the following dynamic control shows a decrease of the coagulation index below 1.10±0.28, at least 600 ml of fresh-frozen plasma is additionally administered, providing thereby the coagulation index by the end of the operation not less than 0.52±0.27.
EFFECT: method provides effective prevention of intra- and postoperative blood loss by prevention of intraoperative homeostatic disorders.
SUBSTANCE: invention refers to medicine, namely to traumatology and orthopaedics, and aims at conservative treatment of plantar fasciitis. That is ensured by administering platelet rich autoplasma in an amount of 2.0 ml for each injection into an attachment point of the plantar aponeurosis to the calcaneum (the heel sac), inner and outer side surfaces of a midfoot, as well as to a plantar surface of the midfoot. The autoplasma is prepared 1-2 hours before the procedure, and it contains from 1243 thousand/mcl to 3029 thousand/mcl platelets. The normal autoplasma contains from 162 thousand/mcl to 358 thousand/mcl platelets. The autoplasma is activated with 0.25% CaCl2 in a ratio of 2:1 with added 5% sodium hydrocarbonate in a ratio of 1:20 to the prepared platelet rich plasma.
EFFECT: above method enables providing pain management, recovering the extremity function, ensuring the stable clinical effect, and preventing complications.
SUBSTANCE: declared invention refers to veterinary science and aims at recovering the estrual cycling and fertility in cows suffering from hypo-ovarionism. The method involves single parenteral administration of the gonadotrophic preparation of a pregnant mare serum gonadotropin - folligon in a dose of 1,000 IU on the 7th day from the beginning of treatment with underlying pre-injections of 2.5% progesterone in a dose of 4 ml, on the 1st, 3rd and 5th days of the therapeutic course, 2% Sinestrol in a dose of 2 ml on the 1st and 3rd days, and Eleovit in a dose of 5 ml on the 1st and 7th day of treatment.
EFFECT: declared invention provides normalising the hormonal-metabolic status and the recovered functional ovarian activity in the cows.
2 tbl, 2 ex
SUBSTANCE: invention refers to medicine and can be used for treating ulcerous pyloroduodenal stenosis. That is ensured by single injections of patient's platelet rich plasma into a gastric mucosa on the periphery of scar tissues of a pyloric canal all around uniformly into 6 points in a dose of 0.2 ml. Then the stenotic area is exposed to ionised argon plasma for 5-8 days in a mode of unipolar spray coagulation at a power of 30 W, an argon flow of 1.5 litres a minute for 5-6 seconds; the number of exposures per one session makes 3 to 5.
EFFECT: invention provides more effective non-invasive treatment of pyloroduodenal stenosis and reduces a length of treatment.
FIELD: medicine, pharmaceutics.
SUBSTANCE: group of inventions refers to medicine and aims at cell protection against the cytopathogenic action of hepatitis C virus. What is declared is a pharmaceutical composition possessing antiviral action on hepatitis C virus and a method for preparing it. The chicken broiler's head is electrically stimulated in a mode of 100-120 V 3-4 A for 3-4 s. The blood is sampled and incubated at 4-8°C for 18-24 hours. The serum is sampled. The sampled serum is filtered through a filter of a pore size of 10 nm, lyophilised and irradiated in a line electron accelerator (LEA) in a mode of 10-40 kGy.
EFFECT: using the declared group of inventions is effective for cell protection against the cytopathogenic action of hepatitis C virus.
2 cl, 2 tbl, 1 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention relates to the pharmaceutical industry, namely to a method of industrial production of fibrin-monomer from the blood plasma. The method of industrial production of fibrin-monomer from the blood plasma consists in defrosting fresh frozen human plasma with continuous mixing, with further addition into plasma of a saturated ammonium sulphate solution, the obtained mixture is kept at a temperature, after which it is centrifuged, a supernatant liquid is poured out; after that, urea is dissolved in a phosphate buffer and heated, with further dissolution in the buffer of the earlier obtained fibrinogen sediment, then, human thrombin is added and mixed; the mixture is kept at a room temperature, further, the obtained mixture is divided into three parts, the phosphate buffer is introduced into a reservoir with one of the three parts of the initial fibrinogen solution, a fibrin clot, formed in the reservoir is collected, washed in distilled water and pressed, as a result, three washed fibrin clots are obtained, after that, washing of the fibrin clot is repeated two more times in the same way, the final product - fibrin-monomer is obtained by dissolution of the washed fibrin clot in an acetate buffer with urea, the obtained fibrin-monomer is poured into flasks, after that, flasks with fibrin-monomer are frozen and freeze-dried under specified conditions.
EFFECT: method makes it possible to increase the output of fibrin-monomer.
SUBSTANCE: what is applied is a stocking coating of an autogenous bone with a patient's platelet-rich plasma. Bone marrow aspirate from the patient's ilium and/or mesenchymal stromal cell autoculture prepared of the aspirate by culturing in vitro are injected under the coating layer into the autogenous bones. The autogenous bones are placed tightly in the bone defect to cover the defect area with adjacent soft tissues.
EFFECT: complete and effective synthesis of the bone tissue continuity by creating conditions of proliferative process isolation and osteoresorption process deceleration in the autogenous bone with no undesired immunological responses in the plasty area.
1 dwg, 1 ex
SUBSTANCE: with underlying conventional treatment, a leukocyte serum preparation is used that is produced by incubation of 20-30 ml of a patient's whole blood bottled in three sealed flasks in a thermostat at a temperature of 37-38°C for 24, 48 and 66-68 hours respectively; then the flasks are removed from the thermostat; the leukocyte serum is aspirated by a sterile syringe; the leukocyte serum preparation prepared at different times is introduced into the patient three times subcutaneously in a dose of 2-5 ml daily or triduan.
EFFECT: method provides higher clinical effectiveness and reduced length of treatment.
2 tbl, 1 ex
SUBSTANCE: invention relates to medicine and specifically to trauma surgery and orthopaedics, and can be sued for surgical treatment of ununited fractures and false joints of cylindrical bones when there is a shortage of soft tissue. The method involves, 5-6 days before an operation, performing needle biopsy of bone and soft tissue fragments from the damage centre of the cylindrical bone and determining presence and nature of obligate intracellular viral infection (OIVI). Super-selective angiographic analysis of the microvascular channel to the capillary link is also performed. Valtrex is administered to the patient 2-4 days before the operation in a dose of 500 mg twice a day. Further, the method involves performing osteosynthesis or re-osteosynthesis with resection of the ends of bone fragments, opening marrowy canals, bone stimulation and batting the space of the bone defect with a gel-like nanostructured composite implant. In the presence of OIVI, resection of bone fragments is carried out in a larger volume until the onset of "pinpoint bleeding", i.e. to areas with satisfactory intrabone blood supply. The composite implant contains thrombocyte-rich autoplasma, mixed in ratio of 1:(1-2) with granules of a complex alloplastic preparation (CAP) based on hydroxyapatite which contains 50-60 wt % collagen. The composite implant also contains either 0.08-2.8 wt % colloidal solution of nanoparticles of zero-valent silver metal Ag0, or gold Au0, or copper Cu0, or palladium Pd0, or platinum Pt0, or 5-12 wt % nanoparticles of said metals in dry form. The nanoparticles have size of 2-40 nm. A colloidal solution of said nanoparticles or colloidal nanoparticles of said metals in dry form is added to the CAP granules. Further, the prepared granules of the gel-like complex alloplastic preparation are laid in a selected ratio on the layer of thrombocyte-rich autoplasma, without mixing, for subsequent transfer into the bone defect space. In case of performing resection of bone fragments in a larger volume until the onset of "pinpoint bleeding", corticotomy is further performed on the cylindrical bone being operated on, with subsequent distraction of the bone regenerate using any existing method. Further, the bone fragments are repositioned, followed by metallo-osteosynthesis. Before wound suturing, the surface of the area with shortage of soft tissue in the projection of the ununited fracture and false joints is covered by a semi-permeable flexible plate made of the complex alloplastic preparation based on hydroxyapatite, which contains 50-60 wt % collagen. The plate has thickness of 0.25-1.2 mm. The surface area of the plate is 10-20% greater than the area with shortage of soft tissue in the corresponding projection. The part of the erythrocyte mass remaining from preparing the thrombocyte-rich autoplasma and the plasma are returned into the bloodstream of the patient by intravenously using a drip during the surgical procedure or in the early post-operation period. After the operation, valtrex is administered to the patient in a dose of 500 gm once a day for two weeks and then in a dose of 500 mg every other day for two weeks.
EFFECT: method provides reliable prevention of OIVI at a damage centre, normalisation of local microcirculation of blood, avoiding ischemic processes, and compensation for the shortening of the length of the limb of the patient being operated on while preventing weakening of the process of reparative osteogenesis and allergic reactions of the body.
6 cl, 4 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention relates to piridazine derivatives of formula II
in which radicals and symbols have determinations, given in the invention formula, or to their pharmaceutically acceptable salts.
EFFECT: compounds of formula II demonstrate inhibiting effect with respect to proteinkinases such as c-met, ron, or ALK, or chimeric proteins, and can be useful for treatment of disorders, associated with abnormal activity of proteinkinases, such as cancer.
7 cl, 1 tbl, 30 ex