Method for preparing dry herbal extract of st. john's wort

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to pharmaceutical and consumer industry in preparing dry herbal extracts used for later colouration of textile fabrics with this extract. A method for preparing the dry herbal extract of St. John's wort involves grinding herbal raw material, extracting in water, filtering, boiling down in a rotary evaporator and drying the residual product to constant weight in a drying chamber in the certain environment.

EFFECT: method described above enables preparing the extract with dry colorant weight 25% of dry herbal raw material weight.

 

The invention relates to pharmaceutical and light industry for preparation of dry plant extracts used for further coloring this extract textiles [1, 2].

In the patent RU 2199312 C1 describes a method of obtaining a dry extract as a medicine. This method involves adding excipients: lactose monohydrate, magnesium stearate, and so on

In the patent RU 2287338 C2 describes a method for tablets of dry extract of St. John's wort, comprising mixing a dry extract with auxiliary substances, seal, screening, processing the condensed extract excipients, including titanium dioxide and talc, followed by pelletizing.

A method of obtaining a dry extract 2192272 (2002) using as adsorbent dry powdered seaweed kelp sugary (Laminaria saccharina) and bladder wrack (Fucus vesiculosus). The disadvantage of this method is the long drying - up to 24 hours.

Known methods for producing dry extract (patent RF №2116797, RF patent №2173557) where the extractant is ethanol and water / ethanol mixture. The disadvantage of this method is the application of organic flammable liquids that require strict security measures and increase the cost of the finished extract.

D is I get dry plant extract were used the following apparatus and materials: electric mill, paper filters, rotary vacuum evaporator mark RM -1, drying Cabinet, scales.

A method includes the following steps:

1. The grinding plant.

2. Extraction of substances from the calculation of 150 grams of vegetable raw materials in 1 liter of water (1:6,6), extracted with water from dry raw material up to 1 litre for 1 hour at the boiling temperature of the solvent.

3. Filtration of the extract.

4. Evaporation of extract obtained at a rotary vacuum evaporator at a temperature of 40-45°C and the atmospheric pressure is 100 mm RT.article.

5. Drying the residue to constant weight in a drying Cabinet at a temperature of 95°C.

The process of evaporation takes place under vacuum at atmospheric pressure of 100 mm RT.article when the boiling temperature of the extract 40°C. the Evaporation in vacuum has certain advantages over evaporation at atmospheric pressure. Evaporation under vacuum gives the possibility to carry out the process at lower temperatures, which is important in the case of concentration of solutions of substances that decompose at elevated temperatures. When the vacuum increases the effective temperature difference between the heating agent and the solution that can reduce the heating surface of the device.

Obtained after evaporation of the product being dried. When drying is the process of removing moisture from the solid. In a drying Cabinet is infrakrasnoe the radiation promotes more intensive removal of moisture.

The result is a resinous substance of a dark brown colour, soluble in water, with a pleasant sweet smell, which is a complex extractive dyes Hypericum perforatum. In appearance resembles a mummy.

The yield of 25.5% by weight of dry plant materials. Developed by the author, the method does not involve the use of additional additives, expensive installations and the use of solvents such as acetone, ethyl and methyl alcohols[3, 4, 5].

The obtained dry extract of St. John's wort is highly soluble in the solvent (water), which was originally extracted.

Finished dry extract enough stored for a long time (5 years or more) at a temperature of +4 -+8°C.

Literature

1. Application No. 2009117627. A positive decision dated 26.10.2010 Asimov F. W., Shagin N. A. The way protravnogo dyeing wool fabric with vegetable dye grass bird from the mountains.

2. Application No. 2012101148. The positive decision from 13.09.2010, Shagin N. A., Asimov F. W. Way protravnogo dyeing wool fabric with vegetable dye Thistle drooping.

3. Neborak O. Y. / Chemical modification and study of the properties of natural vegetable dyes. Diss. ... K. H. N. - M. - 2005. - 120 S.

4. Anna A. D. / technology Development anthocyanin KRA is Italy from vegetable raw materials. Diss. ... K. so-called Voronezh, 2004. - 180 S.

5. Badalov E. K. / Developing ways to improve the efficiency of the extraction process and the quality of the colouring matter of vegetable raw materials. Diss. ... K. so-called Moscow. - 2000. - 130 C.

The method of obtaining dry plant extract of Hypericum perforatum, which includes grinding plant, extraction, filtering the extract, evaporation him in a rotary vacuum evaporator at 40°C and drying the residue to constant weight in a drying Cabinet, characterized in that the evaporation of the extract in a rotary evaporator is carried out at atmospheric pressure of 100 mm RT.art., the mass ratio of dry plant materials and water is 1:6.6 and the yield of dry plant extract amounts to 25.5% by weight of dry plant materials.



 

Same patents:

FIELD: chemistry.

SUBSTANCE: method of obtaining sanguinarine and chelerythrine sulphates includes extraction of milled overground part of macleaya microcarpa and/or macleaya cordata with water aliphatic alcohol, removal of water aliphatic alcohol in vacuum, alkalinisation of water distillation residue with hydrophobic solvent, processing organic phase with sulphuric acid, filtration, washing and drying of target product, with extraction of milled raw material being carried out with water aliphatic alcohol in presence of methanesulphoacid, and solution of alkaloid bases in hydrophobic organic solvent is additionally filtered through layer of hydrophobic solvent, and target product is subjected to boiling in acetone.

EFFECT: method makes it possible to increase quality of finished product, simplify technology of production of sanguinarine and chelerythrine sulphates, and reduce the process duration.

8 cl, 14 ex

FIELD: chemistry.

SUBSTANCE: method of bee pollen processing consists in the fact, that bee pollen is extracted with CO2 by pumping CO2, obtained fat extract is separated, remaining oil-seed meal is subjected to enzymatic hydrolysis in presence of enzyme Distizym Protacide Extra, obtained fermentolisate is separated into solid and liquid phases, solid phase is dried, liquid phase is filtered, preservative potassium sorbate and sodium benzoate are added into filtered liquid fraction under specified conditions.

EFFECT: method makes it possible to efficiently process bee pollen with obtaining fractions, characterised by microbiological purity, high degree of bioavailability, and a long storage term.

4 tbl

FIELD: chemistry.

SUBSTANCE: invention relates to versions of composition for heat transmission. One of composition versions contains (i) from about 20 to about 90 wt % of R-1234yf; (ii) from about 10 to about 60 wt % of R-134a and (iii) from about 1 to about 20 wt % of R-32. Invention also relates to a number of versions of composition application.

EFFECT: composition has lower value of global warming potential and at the same time is characterised by productivity and energy efficiency.

56 cl, 7 dwg

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to pharmaceutical industry, particularly to a method for recovering pinosylvin and methylpinosylvin from common pine (Pinus sylvestris) wood. The method for recovering pinosylvin and methylpinosylvin consists in extracting ground knots of common pine (Pinus sylvestris) wood, common pine (Pinus sylvestris) in isopropyl alcohol mixed with water, separating the extract and removing the solvent.

EFFECT: method enables a higher yield of pinosylvin and methylpinosylvin from common pine (Pinus sylvestris) wood.

3 cl, 5 ex, 2 dwg

FIELD: medicine.

SUBSTANCE: agent possessing the anti-inflammatory, antipyretic and antimicrobial action representing a dry extract of drug hedge hyssop leaves and blossom by grinding them, extracting in 96% alcohol on a water bath to a boil, and boiling, evaporating, diluting the evaporated residue by distilled water first, adding chloroform then, cooling to a room temperature and centrifuging, separating a water fraction and drying it in the certain environment.

EFFECT: agent possesses the pronounced anti-inflammatory, antipyretic and antimicrobial action.

5 dwg, 5 tbl, 2 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to the pharmaceutical industry, in particular to a medication, possessing a nephroprotective action. The medication with the nephroprotective action, contains an extract of grass with roots and rhizomes of slender-leaf iris (Iris tenuifolia), stabilising agents and preservatives, taken in a certain ratio, where the extract is obtained by extraction of the grass with roots and rhizomes of slender-leaf iris (Iris tenuifolia) with a 30-70% water solution of polyol.

EFFECT: medication possesses an effective nephroprotective action.

3 cl, 3 dwg, 7 tbl, 14 ex.

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to the pharmaceutical industry, namely to a method of obtaining a preparation, possessing an antimicrobial activity. The method of obtaining the preparation, possessing he antimicrobial activity, where an aboveground part of freshly harvested bear leek (Allium ursinum L.) or victory onion (Allium victoriale L.) is crushed to a paste-like state, poured with ethyl alcohol, infused tree times, under certain conditions, after each extraction the extracts are poured off, the obtained extracts are combined.

EFFECT: medication, obtained by the claimed method, possesses an expressed antimicrobial activity.

2 cl, 1 tbl, 6 ex

FIELD: food industry.

SUBSTANCE: method involves raw material milling, extraction of useful substances, filtering and drying. The method characterisation is as follows: extraction is performed in an ultrasonic bath with a food acid with concentration not in excess of 5% in conversion to adipic acid at a temperature of 20-40°C during 15-30 min while drying is performed by high-temperature spraying method at a temperature of 70-100°C in a flow of extract ensuring production of a powered product. The food acid may be represented by adipic, orthophosphoric, malic, ascorbic, amber or acetic acid.

EFFECT: method enables production of powered preparations of non-fruit sea-buckthorn parts with high serotonin content.

2 cl, 1 tbl, 1 ex

FIELD: agriculture.

SUBSTANCE: method of complex processing of rice production wastes in the form of rice hulls and straw comprises preparing raw material by screening hulling bran or dust and washing with water, processing the prepared raw material to produce a solid phase and solution of organic compounds, at that in preparing the raw material the rice straw is crushed, the prepared raw material is treated with 0.5 N ammonium oxalate solution, the solid phase is separated from the solution by filtration and sent to the recovery of silicon-containing products, the filtrate is dialyzed against running water and then against distilled water, concentrated, treated with acetone or alcohol, the resulting precipitate is separated by centrifugation, dissolved in water and lyophilized to obtain the polysaccharides under certain conditions.

EFFECT: method enables to increase the number of target products extracted during processing of rice production wastes, to improve environmental security of production by minimizing the amount of wastes, while simultaneous expanding the resource base through the use of rice straw.

4 cl, 2 ex

FIELD: medicine.

SUBSTANCE: invention represents a natural antioxidant preparation technology for cosmetic applications. The presented method for preparing a biologically active extract of grape berries or secondary wine making products - husks of grapes - provides drying the raw material, grinding, mixing it with an extactant in a ratio of 1:2.

EFFECT: method provides producing the all-purpose antioxidant for all types of cosmetics rich in biologically active substances with the relatively simple technological process requiring no organic acids used.

1 cl, 2 ex, 1 tbl, 1 dwg

FIELD: medicine.

SUBSTANCE: invention represents an agent for the intracellular delivery of a biologically active high-molecular compound containing a high-molecular compound specified in milk serum protein, peptide fragments of milk serum protein, protein of porcine transmissible gastroenteritis virus, thermally-stable tuberculin protein recovered from the mycobacteria Mycobacterium bovi, M1 protein of influenza virus of the strain PR8, protein of VP1 foot-and-mouth disease virus, nanoparticles - colloidal selenium, distilled water with the ingredients of the agent taken in certain relations, wt %.

EFFECT: creating non-toxic and effective agent for intracellular delivery of biologically active substances.

4 cl, 1 tbl, 6 ex

FIELD: chemistry.

SUBSTANCE: gadopentetate-modified beta-cyclodextrin derivatives, characterised by that the contrast medium used is beta-cyclodextrin containing one, two or three gadopentetate residues or a mixture thereof with general formula (C42H70-nO35)(C14H21N3O8)nGdn, where n=1-3.

EFFECT: improved properties.

2 cl, 1 tbl, 3 ex, 9 dwg

FIELD: medicine.

SUBSTANCE: first, the method involves teeth cleaning, surgical site isolation with cotton swabs, drug-induced treatment of 2% chlorhexidine and drying. Then, an erosion surface and adjoining solid dental tissues are coated with a phytoapipreparation for 15-20 minutes. The preparation is presented in the form of an ointment and has the following composition, weight fractions: 40% alcoholate (1:10) of tartarian catchfly or rhizomes and roots of maral root 10 ml, 40% alcoholate (1:10) of spirea herb 5 ml, apilac 0.5 g, clove ester 0.5 ml, lanolin 25.2 g, Vaselin 58.8 g. The ointment is used once a day for 10 days with the patients advised to avoid eating for one hour.

EFFECT: method is easy-to-use and physiological, and ensures an absolute recovery.

2 ex

FIELD: chemistry.

SUBSTANCE: invention represents aerosol repellent substance, containing N,N-diethyl-m-toluamide, solvent, evacuating gas, softening additive and fragrance component with vanilla fragrance, with components in substance being present in specified ratio in wt %.

EFFECT: extension of arsenal of means for protection against blood-sucking insects.

6 cl, 5 ex, 2 tbl

FIELD: medicine.

SUBSTANCE: invention can be used for the nutritive correction of the morphofunctional state of sportsmen at the stages of a training and competitive cycle (TCC). That is ensured by supplying the basic food intake with multi-component natural concentrated food substances (NCFSs) rich in biologically active substances (BASs) of herbal (HNCFSs) and/or protein and herbal (PHNCFSs) with consideration for solving the problems of the nutritional support in sportsmen of various sports according to the peculiarities of their professional athletic performance at the specific stages of the TCC.

EFFECT: preventing the developing prenosological and pathological states in the sportsman, achieving the high performance and stably high sports results.

2 cl, 3 tbl, 2 ex

Lip care product // 2540906

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to cosmetology and represents a lip care product containing the ingredients (a) and (b) below, wherein an amount of the ingredient (b) in mixture makes 20 to 70 wt %: a) polyglycerol isostearate 5 to 20 wt %, wherein number of attached glycerol moles makes 4 to 10, while number of isostearic acid residues makes 1 to 4; and (b): (b1) methyl phenyl silicone 20 to 70 wt %, wherein methyl phenyl silicone contains diphenyl siloxyphenyl trimethicone, (b2) pentafluoride ester 0 to 45 wt %.

EFFECT: invention provides the excellent effect of secondary adhesion resistance immediately after the application and possess the excellent gloss and stability.

9 cl, 7 ex, 9 tbl

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to compounds of structural formula (I), which can be used for treating diseases mediated by an androgen receptor. In formula (I), R1 means (C2-6)alkyl, (C1-6)alkyloxy, -S(O)m-(C1-6)alkyl, (C1-6)fluoroalkyl, CN or halogen, R2 and R3 are identical or different and mean a hydrogen atom or (C1-9)alkyl, R4, R5, R6, R7 are identical or different and mean a hydrogen or halogen, X means CH or N, Y means either a nitrogen atom, or a carbon atom substituted by (C1-6)alkyl, (C1-6)alkyloxy, (C1-6)fluoroalkyl, a hydrogen atom or halogen; m is equal to 0, 1 or 2.

EFFECT: invention refers to using the compounds for preparing a therapeutic agent for preventing and/or treating hirsutism, androgenetic alopecia, hypertrichosis, atopic dermatitis, disordered sebaceous gland, such as hyperseborrhea, acne, greasy skin or seborrheic dermatitis.

8 cl, 2 tbl, 26 ex

FIELD: chemistry.

SUBSTANCE: invention relates to a novel method of producing hydrogels based on a crosslinked polymer, particularly obtained from polysaccharide or from one salt thereof. The method of producing crosslinked gel includes at least a step of: a) obtaining an aqueous medium containing at least one polysaccharide, b) forming a homogeneous gel from the medium obtained at step (a), c) bringing the gel obtained at step (b) into contact with an effective amount of at least one crosslinking agent, d) crosslinking said mixture formed at step (c), and e) extracting said crosslinked hydrogel. At least said steps (a) to (d) are carried out in a sealed chamber, bounded at least in part by a deformable wall, wherein said mixture in the chamber undergoes step (d) at conditions which facilitate crosslinking.

EFFECT: method improves homogenisation of the polymer before crosslinking and improves the correct progression of the crosslinking process.

19 cl, 7 dwg, 3 tbl, 3 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to pharmaceutical industry, namely to a composition for preventing or treating gastrointestinal dysmotilities and to a food functional therapeutic composition for preventing or treating gastrointestinal dysmotilities; the above compositions contain mixture of two or more herbs specified in a group consisting of Bupleuri Radix, Coptidis Rhizoma and Glycyrrhizae Radix et Rhizoma.

EFFECT: compositions provide the synergetic effect on preventing or treating gastrointestinal disorders, particularly functional dyspepsia associated with a rate of gastric emptying or a gastrointestinal transit.

6 cl, 5 tbl, 13 ex

FIELD: chemistry.

SUBSTANCE: invention relates to method of obtaining biocompatible highly disperse polylactide particles for in situ manufacturing of diagnostic means for positron-emission tomography by combination of said particles with solution, containing cations of gallium 68 (III). Claimed method includes combination of solution of bidentate aromatic ligand, namely quercetin, quinalizarin, alizarin or 8-hydroxyquinoline in polar solvent with solution, containing lactic acid copolymers in low-polar solvent and intensive mixing of obtained mixture with obtaining highly homogenous mixture. After that, at least three volumes of water solution of polyvinyl alcohol with molecular weight 9.0÷80 kDa are added and intensively mixed with obtaining highly homogenous mixture. Obtained mixture is evaporated with obtaining suspension, which is filtered by filter with pore size less than 30 mcm with obtaining filtrate, with further addition of lyoprotector, freezing and lyophilisation. Invention also relates to biocompatible highly disperse particles for manufacturing radiopharmaceutical preparation for positron-emission tomography, their application for carrying out positron-emission tomography and to diagnostic composition, containing effective amount of gallium-68 (III), bound with said particles.

EFFECT: obtaining biocompatible highly dispersive polylactide particles for in situ manufacturing of diagnostic means for positron-emission tomography.

33 cl, 8 tbl, 6 dwg, 2 ex

FIELD: medicine, oncology, amino acids.

SUBSTANCE: invention relates, in particular, to the development of an antitumor preparation based on natural substances. Invention relates to an amino acid preparation comprising at least one modified essential amino acid obtained by treatment of amino acid by ultraviolet radiation (UV) at wavelength 250-350 nm for 12-80 h at temperature 15-30oC or with ozone at temperature 15-25oC. The modified amino acid has no toxicity for health cells. Also, invention relates to a method for preparing such preparation. Invention provides the development of an antitumor preparation based on modified amino acids and expanded assortment of antitumor preparations being without cytotoxicity for normal cells.

EFFECT: valuable medicinal antitumor properties of preparation.

8 cl, 4 tbl, 2 dwg, 4 ex

Up!